#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q92569	uniprotkb:Q5SXH7-1	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-26412802	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:q5sxh7-1(display_long)|uniprotkb:PLEKHS1(gene name)|psi-mi:PLEKHS1(display_short)|uniprotkb:C10orf81(gene name synonym)|uniprotkb:Epididymis luminal protein 185(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691503|imex:IM-22632-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	intact:EBI-10691507(isoform-parent)|entrezgene/locuslink:79949(identity)|refseq:XM_005270162.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), BMX (P51813), FER (P16591), FES (P07332), FGR (P09769), FRK (P42685), FYN (P06241), HCK (P08631), SRC (P12931), SYK (P43405), TNK1 (Q13470), YES1 (P07947)."|comment:"The interaction failed to show if a kinase-dead K299M version of FYN (P06241) or kinase-dead versions of ABL2 (P42684), FES (P07332) or TNK1 (Q13470) were used."|figure legend:Suppl. table S3, fig. 2D, suppl. Fig. S6, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2020/10/22	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:8OuCSDcvw9rtC0JZC596NetxIKA9606	intact-crc:35BA53DB37200827|rigid:/gCqH01nPA8E1ZE/l/NkTtgRxWo	false	mutation disrupting interaction:383-383|phosphorylated residue:?-?	sufficient binding region:181-462|mutation disrupting interaction:68-68|phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UQB8-6	uniprotkb:Q13322	intact:EBI-9092016	intact:EBI-80275|uniprotkb:O00427|uniprotkb:O00701|uniprotkb:O75222|uniprotkb:Q92606|uniprotkb:Q92907|uniprotkb:Q92948|intact:EBI-1760363|ensembl:ENSP00000381793|ensembl:ENSP00000385770|intact:EBI-1965437|uniprotkb:A7VJ95|uniprotkb:A4D258|uniprotkb:A8K0E6|uniprotkb:D3DVM9	psi-mi:q9uqb8-6(display_long)|uniprotkb:Fas ligand-associated factor 3(gene name synonym)|uniprotkb:Insulin receptor substrate p53/p58(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:BAIAP2(gene name)|psi-mi:BAIAP2(display_short)	psi-mi:grb10_human(display_long)|uniprotkb:GRB10(gene name)|psi-mi:GRB10(display_short)|uniprotkb:GRBIR(gene name synonym)|uniprotkb:KIAA0207(gene name synonym)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Insulin receptor-binding protein Grb-IR(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691537|imex:IM-22632-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-525456(isoform-parent)|uniprotkb:Q9UQB8-6(isoform-parent)|refseq:XM_005256948.1(identity)|entrezgene/locuslink:10458(identity)	go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904738"(vascular associated smooth muscle cell migration)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035036|interpro:IPR035037|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q13322|rcsb pdb:1NRV|rcsb pdb:3HK0|reactome:R-HSA-1433557|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-9607240|reactome:R-HSA-9648895|ensembl:ENSG00000106070(gene)|ensembl:ENST00000398812(transcript)|ensembl:ENST00000401949(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010467"(gene expression)|refseq:XP_011513606.1|refseq:XP_011513614.1|refseq:XP_011513618.1|refseq:NP_001001549.1|refseq:NP_001001550.1|refseq:NP_001001555.1|refseq:NP_005302.3|refseq:XP_016867534.1|refseq:XP_016867535.1|refseq:XP_016867552.1|refseq:XP_016867553.1|refseq:XP_016867554.1|refseq:XP_016867555.1|refseq:XP_016867556.1|refseq:XP_016867557.1|dip:DIP-31657N|refseq:NM_001001550.2(identity)|entrezgene/locuslink:2887(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:n2iqdXaDCA6aLxGI9wl3/44N3ws9606	rogid:WBLkjS4iCC2gMTzR3izSFXGrBnk9606	intact-crc:9AE9B68C17DA2A02|rigid:3PUW4d7N68dSWbKahl2aOtpiQZQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?|sufficient binding region:59-594	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13322	uniprotkb:Q9UKA8	intact:EBI-80275|uniprotkb:O00427|uniprotkb:O00701|uniprotkb:O75222|uniprotkb:Q92606|uniprotkb:Q92907|uniprotkb:Q92948|intact:EBI-1760363|ensembl:ENSP00000381793|ensembl:ENSP00000385770|intact:EBI-1965437|uniprotkb:A7VJ95|uniprotkb:A4D258|uniprotkb:A8K0E6|uniprotkb:D3DVM9	intact:EBI-9091952|uniprotkb:A4GU14|uniprotkb:Q9UKA7|uniprotkb:E7ENV1|uniprotkb:Q5ECL3|uniprotkb:A4LA69|uniprotkb:Q5TGC6|uniprotkb:E7EWD8|uniprotkb:Q9NUC8|uniprotkb:E3VWE2|uniprotkb:E5L4P0|uniprotkb:E5L4P7|uniprotkb:G1FI66|uniprotkb:G1FLF0|ensembl:ENSP00000363516|ensembl:ENSP00000445401	psi-mi:grb10_human(display_long)|uniprotkb:GRB10(gene name)|psi-mi:GRB10(display_short)|uniprotkb:GRBIR(gene name synonym)|uniprotkb:KIAA0207(gene name synonym)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Insulin receptor-binding protein Grb-IR(gene name synonym)	psi-mi:rcan3_human(display_long)|uniprotkb:DSCR1L2(gene name synonym)|uniprotkb:Down syndrome candidate region 1-like protein 2(gene name synonym)|uniprotkb:Myocyte-enriched calcineurin-interacting protein 3(gene name synonym)|uniprotkb:Regulator of calcineurin 3(gene name synonym)|uniprotkb:RCAN3(gene name)|psi-mi:RCAN3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691554|imex:IM-22632-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904738"(vascular associated smooth muscle cell migration)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035036|interpro:IPR035037|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q13322|rcsb pdb:1NRV|rcsb pdb:3HK0|reactome:R-HSA-1433557|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-9607240|reactome:R-HSA-9648895|ensembl:ENSG00000106070(gene)|ensembl:ENST00000398812(transcript)|ensembl:ENST00000401949(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010467"(gene expression)|refseq:XP_011513606.1|refseq:XP_011513614.1|refseq:XP_011513618.1|refseq:NP_001001549.1|refseq:NP_001001550.1|refseq:NP_001001555.1|refseq:NP_005302.3|refseq:XP_016867534.1|refseq:XP_016867535.1|refseq:XP_016867552.1|refseq:XP_016867553.1|refseq:XP_016867554.1|refseq:XP_016867555.1|refseq:XP_016867556.1|refseq:XP_016867557.1|dip:DIP-31657N|refseq:NM_001001550.2(identity)|entrezgene/locuslink:2887(identity)	refseq:NP_001238911.1|refseq:NP_001238912.1|refseq:NP_001238914.1|refseq:NP_038469.1|refseq:NP_001238906.1|refseq:NP_001238907.1|refseq:NP_001238908.1|refseq:NP_001238909.1|refseq:NP_001238910.1|refseq:NP_001238913.1|ensembl:ENSG00000117602(gene)|ensembl:ENST00000374395(transcript)|ensembl:ENST00000538532(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031013"(troponin I binding)|interpro:IPR006931(Calcipressin)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034923|interpro:IPR035979|refseq:NM_001251979.1(identity)|entrezgene/locuslink:11123(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:WBLkjS4iCC2gMTzR3izSFXGrBnk9606	rogid:GcjmPxKst3ISAOr1WMhJLrYq8JY9606	intact-crc:C46C4CA6DC5EA459|rigid:RZk1QOuo+ApD3Yvs9QnA7TkBcmQ	false	sufficient binding region:59-594|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZW8	uniprotkb:O15460-2	intact:EBI-7543499|intact:MINT-1493010|uniprotkb:Q96JV4|uniprotkb:Q8WV64|uniprotkb:A6NMJ7|uniprotkb:Q71RB7|ensembl:ENSP00000254051	intact:EBI-10182841|ensembl:ENSP00000353772|ensembl:ENSP00000368379|ensembl:ENSP00000368394	psi-mi:tens4_human(display_long)|uniprotkb:TNS4(gene name)|psi-mi:TNS4(display_short)|uniprotkb:CTEN(gene name synonym)|uniprotkb:PP14434(orf name)|uniprotkb:C-terminal tensin-like protein(gene name synonym)	psi-mi:o15460-2(display_long)|uniprotkb:Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2(gene name synonym)|uniprotkb:UNQ290/PRO330(orf name)|uniprotkb:P4HA2(gene name)|psi-mi:P4HA2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691571|imex:IM-22632-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116254.4|ensembl:ENSG00000131746(gene)|ensembl:ENST00000254051(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0008104"(protein localization)|interpro:IPR000980(SH2 motif)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR033929|interpro:IPR036860|mint:Q8IZW8|reactome:R-HSA-8875513|refseq:NM_032865.5(identity)|entrezgene/locuslink:84951(identity)	ensembl:ENSG00000072682(gene)|ensembl:ENST00000360568(transcript)|ensembl:ENST00000379086(transcript)|ensembl:ENST00000379100(transcript)|intact:EBI-348033(isoform-parent)|uniprotkb:O15460-2(isoform-parent)|refseq:NM_001017974.1(identity)|entrezgene/locuslink:8974(identity)	-	comment:mint|function:"May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3"	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:k439rXw6HuByQ+t4anCFT0Q23us9606	rogid:YndwsjPs3tNpYhzRLkuABcY2+549606	intact-crc:73723E247A8C512D|rigid:WP/tQSw+aJD43GCqvfmcRxFYGv0	false	phosphorylated residue:?-?|sufficient binding region:236-715	phosphorylated residue:?-?|sufficient binding region:30-533	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEC7	uniprotkb:Q8IZW8	intact:EBI-8469616|intact:MINT-6779113|uniprotkb:Q9H8S3|uniprotkb:A8MVD3|uniprotkb:A8K8J0|uniprotkb:H9KV97|ensembl:ENSP00000353695|ensembl:ENSP00000378216|ensembl:ENSP00000422354	intact:EBI-7543499|intact:MINT-1493010|uniprotkb:Q96JV4|uniprotkb:Q8WV64|uniprotkb:A6NMJ7|uniprotkb:Q71RB7|ensembl:ENSP00000254051	psi-mi:gstcd_human(display_long)|uniprotkb:GSTCD(gene name)|psi-mi:GSTCD(display_short)	psi-mi:tens4_human(display_long)|uniprotkb:TNS4(gene name)|psi-mi:TNS4(display_short)|uniprotkb:CTEN(gene name synonym)|uniprotkb:PP14434(orf name)|uniprotkb:C-terminal tensin-like protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691590|imex:IM-22632-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530550.1|refseq:XP_011530551.1|refseq:XP_011530554.1|refseq:NP_001026890.2|refseq:NP_079027.2|refseq:XP_005263279.1|ensembl:ENSG00000138780(gene)|ensembl:ENST00000360505(transcript)|ensembl:ENST00000394728(transcript)|ensembl:ENST00000515279(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR025714|interpro:IPR029063|interpro:IPR036282|mint:Q8NEC7|entrezgene/locuslink:79807(identity)|refseq:NM_001031720.3(identity)	refseq:NP_116254.4|ensembl:ENSG00000131746(gene)|ensembl:ENST00000254051(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0008104"(protein localization)|interpro:IPR000980(SH2 motif)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR033929|interpro:IPR036860|mint:Q8IZW8|reactome:R-HSA-8875513|refseq:NM_032865.5(identity)|entrezgene/locuslink:84951(identity)	-	comment:mint|comment:homomint	comment:mint|function:"May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3"	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:jg34D624i8iGCgGTedM+tfGgmRQ9606	rogid:k439rXw6HuByQ+t4anCFT0Q23us9606	intact-crc:4620E51421D513C6|rigid:0o/vD8Aq2+oNEbAY1Tm7sTvr6yA	false	phosphorylated residue:?-?	sufficient binding region:236-715|phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZW8	uniprotkb:Q86UA6-6	intact:EBI-7543499|intact:MINT-1493010|uniprotkb:Q96JV4|uniprotkb:Q8WV64|uniprotkb:A6NMJ7|uniprotkb:Q71RB7|ensembl:ENSP00000254051	intact:EBI-10691610|ensembl:ENSP00000439939	psi-mi:tens4_human(display_long)|uniprotkb:TNS4(gene name)|psi-mi:TNS4(display_short)|uniprotkb:CTEN(gene name synonym)|uniprotkb:PP14434(orf name)|uniprotkb:C-terminal tensin-like protein(gene name synonym)	psi-mi:q86ua6-6(display_long)|uniprotkb:RPAIN(gene name)|psi-mi:RPAIN(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Delta3(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691607|imex:IM-22632-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116254.4|ensembl:ENSG00000131746(gene)|ensembl:ENST00000254051(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0008104"(protein localization)|interpro:IPR000980(SH2 motif)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR033929|interpro:IPR036860|mint:Q8IZW8|reactome:R-HSA-8875513|refseq:NM_032865.5(identity)|entrezgene/locuslink:84951(identity)	intact:EBI-3907663(isoform-parent)|ensembl:ENSG00000129197(gene)|ensembl:ENST00000536255(transcript)|refseq:NM_001160246.1(identity)|entrezgene/locuslink:84268(identity)	-	comment:mint|function:"May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3"	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2018/04/06	rogid:k439rXw6HuByQ+t4anCFT0Q23us9606	rogid:O1pqZEoKwTB9kuzAQJM5x81s9z09606	intact-crc:AF7A6B21029E15E4|rigid:Ouc5emBEu2sqbtG+dUGqWoqywTQ	false	phosphorylated residue:?-?|sufficient binding region:236-715	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZW8	uniprotkb:P27986-2	intact:EBI-7543499|intact:MINT-1493010|uniprotkb:Q96JV4|uniprotkb:Q8WV64|uniprotkb:A6NMJ7|uniprotkb:Q71RB7|ensembl:ENSP00000254051	intact:EBI-9090282|ensembl:ENSP00000338554	psi-mi:tens4_human(display_long)|uniprotkb:TNS4(gene name)|psi-mi:TNS4(display_short)|uniprotkb:CTEN(gene name synonym)|uniprotkb:PP14434(orf name)|uniprotkb:C-terminal tensin-like protein(gene name synonym)	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691628|imex:IM-22632-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116254.4|ensembl:ENSG00000131746(gene)|ensembl:ENST00000254051(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0008104"(protein localization)|interpro:IPR000980(SH2 motif)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR033929|interpro:IPR036860|mint:Q8IZW8|reactome:R-HSA-8875513|refseq:NM_032865.5(identity)|entrezgene/locuslink:84951(identity)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	-	comment:mint|function:"May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3"	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:k439rXw6HuByQ+t4anCFT0Q23us9606	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	intact-crc:6678A5C6251E1B5C|rigid:+lSZd9O464pLojaIzScnwivqPcQ	false	phosphorylated residue:?-?|sufficient binding region:236-715	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZW8	uniprotkb:O00746	intact:EBI-7543499|intact:MINT-1493010|uniprotkb:Q96JV4|uniprotkb:Q8WV64|uniprotkb:A6NMJ7|uniprotkb:Q71RB7|ensembl:ENSP00000254051	intact:EBI-744871|uniprotkb:Q5U0M9|ensembl:ENSP00000219479|uniprotkb:A2IDD0	psi-mi:tens4_human(display_long)|uniprotkb:TNS4(gene name)|psi-mi:TNS4(display_short)|uniprotkb:CTEN(gene name synonym)|uniprotkb:PP14434(orf name)|uniprotkb:C-terminal tensin-like protein(gene name synonym)	psi-mi:ndkm_human(display_long)|uniprotkb:nm23-H4(gene name synonym)|uniprotkb:Nucleoside diphosphate kinase D(gene name synonym)|uniprotkb:NME4(gene name)|psi-mi:NME4(display_short)|uniprotkb:NM23D(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691645|imex:IM-22632-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116254.4|ensembl:ENSG00000131746(gene)|ensembl:ENST00000254051(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0008104"(protein localization)|interpro:IPR000980(SH2 motif)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR033929|interpro:IPR036860|mint:Q8IZW8|reactome:R-HSA-8875513|refseq:NM_032865.5(identity)|entrezgene/locuslink:84951(identity)	refseq:NP_001273362.1|refseq:NP_001273364.1|refseq:NP_001273365.1|refseq:NP_001273367.1|refseq:NP_001273368.1|refseq:NP_001273369.1|refseq:NP_005000.1|ensembl:ENSG00000103202(gene)|ensembl:ENST00000219479(transcript)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006869"(lipid transport)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:O00746|rcsb pdb:1EHW|reactome:R-HSA-499943|refseq:NM_005009.2(identity)|entrezgene/locuslink:4833(identity)	-	comment:mint|function:"May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3"	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:k439rXw6HuByQ+t4anCFT0Q23us9606	rogid:ybA9I8oT+oz1iuGLHT7WR1SAaKY9606	intact-crc:0A9C1D974295B7B3|rigid:wAiIdSFqzQvz5Uvqd9LZJMXiEnY	false	phosphorylated residue:?-?|sufficient binding region:236-715	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y600	uniprotkb:Q9NRF2-2	intact:EBI-7095219|ensembl:ENSP00000410648|ensembl:ENSP00000415485|intact:MINT-4832217|uniprotkb:Q9UNJ5|uniprotkb:Q9Y601|uniprotkb:Q4QQH9|uniprotkb:A8K0U4	intact:EBI-10691662|ensembl:ENSP00000337163|ensembl:ENSP00000378903	psi-mi:csad_human(display_long)|uniprotkb:CSAD(gene name)|psi-mi:CSAD(display_short)|uniprotkb:CSD(gene name synonym)|uniprotkb:Cysteine-sulfinate decarboxylase(gene name synonym)|uniprotkb:Sulfinoalanine decarboxylase(gene name synonym)|uniprotkb:Aspartate 1-decarboxylase(gene name synonym)	psi-mi:q9nrf2-2(display_long)|uniprotkb:SH2B1(gene name)|psi-mi:SH2B1(display_short)|uniprotkb:KIAA1299(gene name synonym)|uniprotkb:Pro-rich, PH and SH2 domain-containing signaling mediator(gene name synonym)|uniprotkb:SH2 domain-containing protein 1B(gene name synonym)|uniprotkb:SH2B(gene name synonym)|uniprotkb:Beta(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691666|imex:IM-22632-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011536748.1|ensembl:ENSG00000139631(gene)|ensembl:ENST00000444623(transcript)|ensembl:ENST00000453446(transcript)|go:"GO:0004068"(aspartate 1-decarboxylase activity)|go:"GO:0004782"(sulfinoalanine decarboxylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0019449"(L-cysteine catabolic process to hypotaurine)|go:"GO:0019452"(L-cysteine catabolic process to taurine)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042412"(taurine biosynthetic process)|interpro:IPR002129(Pyridoxal phosphate-dependent decarboxylase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:2JIS|reactome:R-HSA-1614558|refseq:NP_057073.4|refseq:NP_001231634.1|entrezgene/locuslink:51380(identity)|refseq:NM_001244706.1(identity)	ensembl:ENSG00000178188(gene)|ensembl:ENST00000337120(transcript)|ensembl:ENST00000395532(transcript)|intact:EBI-310491(isoform-parent)|uniprotkb:Q9NRF2-2(isoform-parent)|refseq:NM_001145796.1(identity)|entrezgene/locuslink:25970(identity)	-	comment:mint|comment:homomint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FRK (P42685), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:RSNULVRWt2RLIewda7I1hk8HAeY9606	rogid:5DkSyDavhqIn9glTuxAXN/pKPC09606	intact-crc:38B0DF3FBD77E07C|rigid:FSgjqozx/M86YucO9BG7eRZU3iI	false	sufficient binding region:393-493|phosphorylated residue:?-?	sufficient binding region:246-671|phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:O00459	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691685|imex:IM-22632-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409|entrezgene/locuslink:5296(identity)|refseq:NM_005027.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606	intact-crc:2500E2A1608F3842|rigid:EQkrvLH2YoboJ8PKT7kULfTFGnc	false	phosphorylated residue:?-?	sufficient binding region:476-728|phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15117	uniprotkb:P06241	intact:EBI-1753267|uniprotkb:O00359|ensembl:ENSP00000316460|ensembl:ENSP00000426346|uniprotkb:A8K2Y8|uniprotkb:E9PBV9|uniprotkb:Q9NZI9|uniprotkb:B4DLN2	intact:EBI-515315|uniprotkb:Q16248|uniprotkb:Q5R3A6|uniprotkb:Q5R3A7|uniprotkb:Q8N5D7|uniprotkb:B5BU57|intact:EBI-2561531|uniprotkb:E1P557|uniprotkb:H0UI48|ensembl:ENSP00000346671|ensembl:ENSP00000357656	psi-mi:fyb1_human(display_long)|uniprotkb:FYB1(gene name)|psi-mi:FYB1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLAP130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym)	psi-mi:fyn_human(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691702|imex:IM-22632-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011512310.1|refseq:XP_011512311.1|refseq:XP_011512312.1|refseq:NP_955367.1|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|mint:O15117|rcsb pdb:1RI9|rcsb pdb:2GTJ|rcsb pdb:2GTO|reactome:R-HSA-202433|reactome:R-HSA-391160|ensembl:ENSG00000082074(gene)|ensembl:ENST00000351578(transcript)|ensembl:ENST00000515010(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|refseq:NP_001230022.1|refseq:NP_001456.3|refseq:XP_006714527.1|refseq:XP_006714528.1|refseq:XP_006714529.1|dip:DIP-42204N|entrezgene/locuslink:2533(identity)|refseq:NM_199335.3(identity)	refseq:XP_005266947.1|refseq:XP_005266949.1|refseq:NP_002028.1|refseq:NP_694592.1|refseq:NP_694593.1|refseq:XP_016866139.1|refseq:XP_016866140.1|refseq:XP_016866141.1|refseq:XP_016866142.1|refseq:XP_016866143.1|dip:DIP-33876N|ensembl:ENSG00000010810(gene)|ensembl:ENST00000354650(transcript)|ensembl:ENST00000368667(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001764"(neuron migration)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0003015"(heart process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007612"(learning)|go:"GO:0007631"(feeding behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|interpro:IPR036028|interpro:IPR036860|mint:P06241|rcsb pdb:1A0N|rcsb pdb:1AOT|rcsb pdb:1AOU|rcsb pdb:1AVZ|rcsb pdb:1AZG|rcsb pdb:1EFN|rcsb pdb:1FYN|rcsb pdb:1G83|rcsb pdb:1M27|rcsb pdb:1NYF|rcsb pdb:1NYG|rcsb pdb:1SHF|rcsb pdb:1ZBJ|rcsb pdb:2DQ7|rcsb pdb:2MQI|rcsb pdb:2MRJ|rcsb pdb:2MRK|rcsb pdb:3H0F|rcsb pdb:3H0H|rcsb pdb:3H0I|rcsb pdb:3UA6|rcsb pdb:3UA7|rcsb pdb:4D8D|rcsb pdb:4EIK|rcsb pdb:4U17|rcsb pdb:4U1P|rcsb pdb:4ZNX|rcsb pdb:5ZAU|rcsb pdb:6EDF|rcsb pdb:6IPY|rcsb pdb:6IPZ|reactome:R-HSA-114604|reactome:R-HSA-1227986|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5621480|reactome:R-HSA-5621575|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-75892|reactome:R-HSA-8866376|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9706374|reactome:R-HSA-983695|reactome:R-HSA-9670439|entrezgene/locuslink:2534(identity)|refseq:NM_002037.5(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ObeGCVefTolMBQGVT/WhglH5F009606	rogid:GM5wIXENkJgPKwHN+UZBIqUfH6U9606	intact-crc:6F8496B22C38E5F5|rigid:AMYTr7/nqN1KFwwge8ddNFPOyaQ	false	sufficient binding region:488-783|phosphorylated residue:?-?	sufficient binding region:115-537|phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15117	uniprotkb:Q13094	intact:EBI-1753267|uniprotkb:O00359|ensembl:ENSP00000316460|ensembl:ENSP00000426346|uniprotkb:A8K2Y8|uniprotkb:E9PBV9|uniprotkb:Q9NZI9|uniprotkb:B4DLN2	intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794	psi-mi:fyb1_human(display_long)|uniprotkb:FYB1(gene name)|psi-mi:FYB1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLAP130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym)	psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691721|imex:IM-22632-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011512310.1|refseq:XP_011512311.1|refseq:XP_011512312.1|refseq:NP_955367.1|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|mint:O15117|rcsb pdb:1RI9|rcsb pdb:2GTJ|rcsb pdb:2GTO|reactome:R-HSA-202433|reactome:R-HSA-391160|ensembl:ENSG00000082074(gene)|ensembl:ENST00000351578(transcript)|ensembl:ENST00000515010(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|refseq:NP_001230022.1|refseq:NP_001456.3|refseq:XP_006714527.1|refseq:XP_006714528.1|refseq:XP_006714529.1|dip:DIP-42204N|entrezgene/locuslink:2533(identity)|refseq:NM_199335.3(identity)	refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|refseq:NM_005565.3(identity)|entrezgene/locuslink:3937(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), LCK (P06239), LYN (P07948), SRC (P12931), SYK (P43405), YES1 (P07947)."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ObeGCVefTolMBQGVT/WhglH5F009606	rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606	intact-crc:A01401E7A9351C8C|rigid:9rbdQztv+wREwsFELtQU6pI1u+E	false	phosphorylated residue:?-?|sufficient binding region:488-783	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15117	uniprotkb:P06241-3	intact:EBI-1753267|uniprotkb:O00359|ensembl:ENSP00000316460|ensembl:ENSP00000426346|uniprotkb:A8K2Y8|uniprotkb:E9PBV9|uniprotkb:Q9NZI9|uniprotkb:B4DLN2	intact:EBI-10691738|ensembl:ENSP00000229471	psi-mi:fyb1_human(display_long)|uniprotkb:FYB1(gene name)|psi-mi:FYB1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLAP130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym)	psi-mi:p06241-3(display_long)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:p59-Fyn(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691742|imex:IM-22632-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011512310.1|refseq:XP_011512311.1|refseq:XP_011512312.1|refseq:NP_955367.1|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|mint:O15117|rcsb pdb:1RI9|rcsb pdb:2GTJ|rcsb pdb:2GTO|reactome:R-HSA-202433|reactome:R-HSA-391160|ensembl:ENSG00000082074(gene)|ensembl:ENST00000351578(transcript)|ensembl:ENST00000515010(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|refseq:NP_001230022.1|refseq:NP_001456.3|refseq:XP_006714527.1|refseq:XP_006714528.1|refseq:XP_006714529.1|dip:DIP-42204N|entrezgene/locuslink:2533(identity)|refseq:NM_199335.3(identity)	intact:EBI-515315(isoform-parent)|uniprotkb:P06241-3(isoform-parent)|ensembl:ENSG00000010810(gene)|ensembl:ENST00000229471(transcript)|refseq:NM_153048.3(identity)|entrezgene/locuslink:2534(identity)	-	-	isoform-comment:No experimental confirmation available.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ObeGCVefTolMBQGVT/WhglH5F009606	rogid:ixo+4kzKOnoEXQlLRJhsg4vrF089606	intact-crc:5A0B85F3D1FD206C|rigid:/44dTxSAzJWhDg5H2Br7/z+VZb8	false	sufficient binding region:488-783|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15117	uniprotkb:O43639	intact:EBI-1753267|uniprotkb:O00359|ensembl:ENSP00000316460|ensembl:ENSP00000426346|uniprotkb:A8K2Y8|uniprotkb:E9PBV9|uniprotkb:Q9NZI9|uniprotkb:B4DLN2	intact:EBI-713635|uniprotkb:Q9BWN9|uniprotkb:Q9UIC3|ensembl:ENSP00000233154|ensembl:ENSP00000377018|uniprotkb:D3DVK1	psi-mi:fyb1_human(display_long)|uniprotkb:FYB1(gene name)|psi-mi:FYB1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLAP130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym)	psi-mi:nck2_human(display_long)|uniprotkb:NCK adaptor protein 2(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-beta(gene name synonym)|uniprotkb:NCK2(gene name)|psi-mi:NCK2(display_short)|uniprotkb:GRB4(gene name synonym)|uniprotkb:Growth factor receptor-bound protein 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691759|imex:IM-22632-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011512310.1|refseq:XP_011512311.1|refseq:XP_011512312.1|refseq:NP_955367.1|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|mint:O15117|rcsb pdb:1RI9|rcsb pdb:2GTJ|rcsb pdb:2GTO|reactome:R-HSA-202433|reactome:R-HSA-391160|ensembl:ENSG00000082074(gene)|ensembl:ENST00000351578(transcript)|ensembl:ENST00000515010(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|refseq:NP_001230022.1|refseq:NP_001456.3|refseq:XP_006714527.1|refseq:XP_006714528.1|refseq:XP_006714529.1|dip:DIP-42204N|entrezgene/locuslink:2533(identity)|refseq:NM_199335.3(identity)	refseq:XP_006712860.1|refseq:NP_001004720.1|refseq:NP_003572.2|ensembl:ENSG00000071051(gene)|ensembl:ENST00000233154(transcript)|ensembl:ENST00000393349(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0060996"(dendritic spine development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028524|interpro:IPR035559|interpro:IPR035560|interpro:IPR035561|interpro:IPR035883|interpro:IPR036028|interpro:IPR036860|mint:O43639|rcsb pdb:1U5S|rcsb pdb:1WX6|rcsb pdb:1Z3K|rcsb pdb:2B86|rcsb pdb:2CIA|rcsb pdb:2FRW|rcsb pdb:2FRY|rcsb pdb:2JXB|rcsb pdb:4E6R|reactome:R-HSA-186763|reactome:R-HSA-373753|reactome:R-HSA-3928664|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-8985801|reactome:R-HSA-9013420|reactome:R-HSA-9013424|refseq:XP_016860592.1|refseq:XP_016860593.1|refseq:XP_016860594.1|refseq:XP_011510293.1|entrezgene/locuslink:8440(identity)|refseq:NM_001004720.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241), YES1 (P07947)."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ObeGCVefTolMBQGVT/WhglH5F009606	rogid:WV9nJ78Im/ga5KQlRuSN2ODzWpQ9606	intact-crc:81154882C3540EB8|rigid:/9rvBk8yK2DLnFA19wQhHwm1Yco	false	phosphorylated residue:?-?|sufficient binding region:488-783	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92625	uniprotkb:Q92569	intact:EBI-1048612|uniprotkb:Q5JYI9|uniprotkb:Q5SYR2|uniprotkb:Q86WQ7|uniprotkb:A2RUC1|ensembl:ENSP00000353518|uniprotkb:B4DQW8	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:ans1a_human(display_long)|uniprotkb:Odin(gene name synonym)|uniprotkb:ANKS1A(gene name)|psi-mi:ANKS1A(display_short)|uniprotkb:ANKS1(gene name synonym)|uniprotkb:KIAA0229(gene name synonym)|uniprotkb:ODIN(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691776|imex:IM-22632-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056060.2|ensembl:ENSG00000064999(gene)|ensembl:ENST00000360359(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0016322"(neuron remodeling)|go:"GO:0043005"(neuron projection)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:1901187"(regulation of ephrin receptor signaling pathway)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR033637|interpro:IPR036770|interpro:IPR041880|interpro:IPR041882|mint:Q92625|rcsb pdb:2LMR|rcsb pdb:2MYQ|rcsb pdb:6F7O|refseq:NM_015245.2(identity)|entrezgene/locuslink:23294(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:VTw7RU5nIxHSxvQdBUT/YFlQzU89606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:4ECF5FF1DE0DE8B3|rigid:Vw8dTQv+is89fXY1Xe5d2IvKoDk	false	sufficient binding region:675-1134|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q13308	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-2803245|uniprotkb:Q8NFA6|uniprotkb:Q5T650|uniprotkb:Q8NFA8|uniprotkb:Q13417|uniprotkb:Q6IQ54|uniprotkb:Q8NFA5|uniprotkb:Q8NFA7|uniprotkb:A8K974|uniprotkb:B7Z477|uniprotkb:E9PFZ5|ensembl:ENSP00000230419	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:ptk7_human(display_long)|uniprotkb:CCK4(gene name synonym)|uniprotkb:Colon carcinoma kinase 4(gene name synonym)|uniprotkb:Protein-tyrosine kinase 7(gene name synonym)|uniprotkb:PTK7(gene name)|psi-mi:PTK7(display_short)|uniprotkb:Pseudo tyrosine kinase receptor 7(gene name synonym)|uniprotkb:Tyrosine-protein kinase-like 7(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691793|imex:IM-22632-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	refseq:NP_001257327.1|refseq:NP_002812.2|refseq:NP_690619.1|refseq:NP_690620.1|refseq:NP_690621.1|ensembl:ENSG00000112655(gene)|ensembl:ENST00000230419(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001822"(kidney development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003401"(axis elongation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042060"(wound healing)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060026"(convergent extension)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q13308|rcsb pdb:6VG3|refseq:NM_152880.3(identity)|entrezgene/locuslink:5754(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:O4L3LFD0WvN1hDb1abqVBbW1gis9606	intact-crc:B0612FCD1E488272|rigid:Ixtt55EkbO8g18bSBx8jEB3e930	false	phosphorylated residue:?-?	sufficient binding region:594..594-853..853|phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29350-3	uniprotkb:Q05397	intact:EBI-7399369|ensembl:ENSP00000382376|intact:MINT-134096	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:p29350-3(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:PTP1C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691827|imex:IM-22632-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111679(gene)|ensembl:ENST00000399448(transcript)|intact:EBI-78260(isoform-parent)|uniprotkb:P29350-3(isoform-parent)|refseq:NM_080548.4(identity)|entrezgene/locuslink:5777(identity)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	-	comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FES (P07332)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:dOlpiLWoBar/3ryQxTZss7nQqTs9606	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	intact-crc:7862EE34173885C1|rigid:ipDvtaGwayDkWR25O5iN15gbQ28	false	phosphorylated residue:?-?	phosphorylated residue:?-?|sufficient binding region:393..393-1052..1052	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60880	uniprotkb:Q05397	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691844|imex:IM-22632-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N|entrezgene/locuslink:4068(identity)|refseq:NM_002351.4(identity)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	intact-crc:1FB9955E370C33D7|rigid:Rb83Qwprac56pswkZs5QzY+2waA	false	phosphorylated residue:?-?	sufficient binding region:393..393-1052..1052|phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TEW6	uniprotkb:Q05397	intact:EBI-6918542|ensembl:ENSP00000344277|ensembl:ENSP00000455128|uniprotkb:O75209|uniprotkb:Q9BTP2|uniprotkb:Q9NVV3	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:dok4_human(display_long)|uniprotkb:DOK4(gene name)|psi-mi:DOK4(display_short)|uniprotkb:Downstream of tyrosine kinase 4(gene name synonym)|uniprotkb:Insulin receptor substrate 5(gene name synonym)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691810|imex:IM-22632-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000125170(gene)|ensembl:ENST00000340099(transcript)|ensembl:ENST00000569548(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0043410"(positive regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_060580.2|refseq:XP_005256100.1|entrezgene/locuslink:55715(identity)|refseq:NM_018110.3(identity)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BLK (P51451), FGR (P09769), FYN (P06241), HCK (P08631), SRC (P12931), YES1 (P07947)."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Xc4aPsHtdQKj02Q5cqqgw29pSS09606	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	intact-crc:9E7087009389939D|rigid:rpYgJWuUtBjgIn3JYqmPeoTJYv0	false	phosphorylated residue:?-?	phosphorylated residue:?-?|sufficient binding region:393..393-1052..1052	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05397	uniprotkb:Q9NP31	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691878|imex:IM-22632-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BLK (P51451), FGR (P09769), FYN (P06241), HCK (P08631), SRC (P12931), SYK (P43405), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:58618F8E19B391F5|rigid:Nrlu/4OZupxaxYihwZVPX+DqP7w	false	sufficient binding region:393..393-1052..1052|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05397	uniprotkb:Q14451	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	intact:EBI-970191|ensembl:ENSP00000310771|ensembl:ENSP00000377759|ensembl:ENSP00000377761|uniprotkb:B2RAV1|uniprotkb:B3KNL0|uniprotkb:B3KWP9|uniprotkb:B7WP75|uniprotkb:Q53YD3|uniprotkb:Q9Y220|uniprotkb:Q92568|uniprotkb:Q96DF9|intact:EBI-1257061|uniprotkb:J3KQM4	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:grb7_human(display_long)|uniprotkb:GRB7(gene name)|psi-mi:GRB7(display_short)|uniprotkb:GRB7 adapter protein(gene name synonym)|uniprotkb:Epidermal growth factor receptor GRB-7(gene name synonym)|uniprotkb:B47(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691861|imex:IM-22632-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	ensembl:ENSG00000141738(gene)|ensembl:ENST00000309156(transcript)|ensembl:ENST00000394209(transcript)|ensembl:ENST00000394211(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042995"(cell projection)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035032|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q14451|rcsb pdb:1MW4|rcsb pdb:1WGR|rcsb pdb:2L4K|rcsb pdb:2QMS|rcsb pdb:3PQZ|rcsb pdb:4WWQ|rcsb pdb:4X6S|rcsb pdb:5D0J|rcsb pdb:5EEL|rcsb pdb:5EEQ|rcsb pdb:5TYI|rcsb pdb:5U06|rcsb pdb:5U1Q|go:"GO:0042802"(identical protein binding)|reactome:R-HSA-1306955|reactome:R-HSA-186763|reactome:R-HSA-210993|reactome:R-HSA-8853659|reactome:R-HSA-9696273|reactome:R-HSA-1433557|refseq:NP_001025173.1|refseq:NP_001229371.1|refseq:NP_001229372.1|refseq:NP_005301.2|refseq:NP_001317136.1|dip:DIP-502N|entrezgene/locuslink:2886(identity)|refseq:NM_001030002.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rogid:XViWZjk5YwdZFTG3zs2aNdxeFVQ9606	intact-crc:4FE24A1E485AC760|rigid:nJTODhiyHVFKZAo2ndT6Ea3Yjsg	false	sufficient binding region:393..393-1052..1052|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05397	uniprotkb:P46108	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691895|imex:IM-22632-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:E0242AC3FEDB8CD3|rigid:CTv6TM/tNrVySirPOGGTdlAhD7I	false	sufficient binding region:393..393-1052..1052|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11277	uniprotkb:Q9NP31	intact:EBI-514908|uniprotkb:Q15510|uniprotkb:Q15519|ensembl:ENSP00000374370	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:sptb1_human(display_long)|uniprotkb:Beta-I spectrin(gene name synonym)|uniprotkb:SPTB(gene name)|psi-mi:SPTB(display_short)|uniprotkb:SPTB1(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691912|imex:IM-22632-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000338.3|refseq:NP_001020029.1|refseq:XP_005268080.1|refseq:XP_016877101.1|refseq:XP_016877103.1|dip:DIP-1021N|ensembl:ENSG00000070182(gene)|ensembl:ENST00000389720(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0008091"(spectrin)|go:"GO:0009986"(cell surface)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031235"(intrinsic component of the cytoplasmic side of the plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051015"(actin filament binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|rcsb pdb:1S35|rcsb pdb:3EDU|rcsb pdb:3F57|rcsb pdb:3KBT|rcsb pdb:3KBU|rcsb pdb:3LBX|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878|entrezgene/locuslink:6710(identity)|refseq:NM_001024858.2(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), TNK1 (Q13470), YES1 (P07947)."|comment:"The interaction failed to show if kinase-dead versions of ABL2 (P42684) or TNK1 (Q13470) were used."|figure legend:Suppl. table S3, suppl. figs. S3 and S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:pMUYFaSR/cKouM4GMi36sGK6aOU9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:10BA00BA2FB1466A|rigid:Jr7HpZGJcHRcOVVjgRxaw/pChMA	false	sufficient binding region:1978..1978-2117..2117|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11277	uniprotkb:P42224	intact:EBI-514908|uniprotkb:Q15510|uniprotkb:Q15519|ensembl:ENSP00000374370	intact:EBI-1057697|uniprotkb:Q53S88|uniprotkb:Q53XW4|uniprotkb:B2RCA0|uniprotkb:Q9UDL5|uniprotkb:A8K989|uniprotkb:D2KFR8|uniprotkb:Q68D00|uniprotkb:D3DPI7|ensembl:ENSP00000354394|ensembl:ENSP00000386244|ensembl:ENSP00000388240|ensembl:ENSP00000438703	psi-mi:sptb1_human(display_long)|uniprotkb:Beta-I spectrin(gene name synonym)|uniprotkb:SPTB(gene name)|psi-mi:SPTB(display_short)|uniprotkb:SPTB1(gene name synonym)	psi-mi:stat1_human(display_long)|uniprotkb:STAT1(gene name)|psi-mi:STAT1(display_short)|uniprotkb:Transcription factor ISGF-3 components p91/p84(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691930|imex:IM-22632-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000338.3|refseq:NP_001020029.1|refseq:XP_005268080.1|refseq:XP_016877101.1|refseq:XP_016877103.1|dip:DIP-1021N|ensembl:ENSG00000070182(gene)|ensembl:ENST00000389720(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0008091"(spectrin)|go:"GO:0009986"(cell surface)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031235"(intrinsic component of the cytoplasmic side of the plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051015"(actin filament binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|rcsb pdb:1S35|rcsb pdb:3EDU|rcsb pdb:3F57|rcsb pdb:3KBT|rcsb pdb:3KBU|rcsb pdb:3LBX|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878|entrezgene/locuslink:6710(identity)|refseq:NM_001024858.2(identity)	refseq:NP_009330.1|refseq:NP_644671.1|rcsb pdb:1YVL|rcsb pdb:2KA6|rcsb pdb:3WWT|reactome:R-HSA-1059683|reactome:R-HSA-1169408|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8939902|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9013508|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-909733|rcsb pdb:1BF5|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-912694|refseq:XP_006712781.1|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|ensembl:ENSG00000115415(gene)|ensembl:ENST00000361099(transcript)|ensembl:ENST00000409465(transcript)|ensembl:ENST00000415035(transcript)|ensembl:ENST00000540176(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|mint:P42224|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|dip:DIP-46140N|refseq:NM_139266.2(identity)|entrezgene/locuslink:6772(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FYN (P06241), JAK2 (O60674)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:pMUYFaSR/cKouM4GMi36sGK6aOU9606	rogid:a2ZnhdFZkctbjaXLpsYNJ3q5Cv49606	intact-crc:44F92DBF8B7C2FE8|rigid:yymDRYobX8oeik/Okwk27J1b6OI	false	phosphorylated residue:?-?|sufficient binding region:1978..1978-2117..2117	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y3P9	uniprotkb:P40763	intact:EBI-1057545|uniprotkb:Q05CW2|uniprotkb:Q6ZMY1|uniprotkb:Q9HA28|uniprotkb:Q9P0E2|uniprotkb:Q9UG67|intact:EBI-2948690|uniprotkb:B9A6L2|ensembl:ENSP00000362751	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:rbgp1_human(display_long)|uniprotkb:RABGAP1(gene name)|psi-mi:RABGAP1(display_short)|uniprotkb:HSPC094(orf name)|uniprotkb:Rab6 GTPase-activating protein GAPCenA(gene name synonym)|uniprotkb:GAP and centrosome-associated protein(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691947|imex:IM-22632-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011516742.1|refseq:XP_011516743.1|refseq:NP_036329.3|ensembl:ENSG00000011454(gene)|ensembl:ENST00000373647(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0015631"(tubulin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022164|interpro:IPR033185|interpro:IPR035969|mint:Q9Y3P9|rcsb pdb:4NC6|reactome:R-HSA-8854214|refseq:XP_016870056.1|refseq:XP_016870057.1|refseq:XP_016870058.1|refseq:NM_012197.3(identity)|entrezgene/locuslink:23637(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:yGnx7q5tyqYfpbeVDwZ8IKI1o+k9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:577E21DB5E77143D|rigid:Km7Mra6GdbQsiOdGNk8Fh3/Xsmk	false	sufficient binding region:73-1069|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46109	uniprotkb:Q9H0V1	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	intact:EBI-10691967|uniprotkb:Q8NEK4|uniprotkb:B4DDS0|uniprotkb:A4D0T9|uniprotkb:Q9H8J2|ensembl:ENSP00000323068|ensembl:ENSP00000390696	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:tm168_human(display_long)|uniprotkb:TMEM168(gene name)|psi-mi:TMEM168(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691964|imex:IM-22632-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|entrezgene/locuslink:1399(identity)|refseq:NM_005207.3(identity)	refseq:NP_001274426.1|refseq:NP_071929.3|ensembl:ENSG00000146802(gene)|ensembl:ENST00000312814(transcript)|ensembl:ENST00000454074(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|interpro:IPR029713|refseq:XP_016868012.1|refseq:XP_016868014.1|refseq:NM_022484.5(identity)|entrezgene/locuslink:64418(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:SnJHXvhXT7kCxoT+82XkdTiSySY9606	intact-crc:AA59F4477B2538DB|rigid:DrFOfcIXi90bXuuCXhWU80ZdnsM	false	phosphorylated residue:?-?	sufficient binding region:272-697|phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BVC4	uniprotkb:Q8NEU8	intact:EBI-1387471|intact:EBI-1567843|uniprotkb:Q5M800|uniprotkb:Q86Y18|uniprotkb:Q8WUI5|uniprotkb:Q9HA66|uniprotkb:Q9UJV6|uniprotkb:B4DY00|uniprotkb:B3KMM4|uniprotkb:D3DU88|ensembl:ENSP00000380313|ensembl:ENSP00000455046|ensembl:ENSP00000456405|ensembl:ENSP00000457870	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	psi-mi:lst8_human(display_long)|uniprotkb:MLST8(gene name)|psi-mi:MLST8(display_short)|uniprotkb:GBL(gene name synonym)|uniprotkb:G protein beta subunit-like(gene name synonym)|uniprotkb:LST8(gene name synonym)|uniprotkb:Mammalian lethal with SEC13 protein 8(gene name synonym)	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10691989|imex:IM-22632-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186102.1|refseq:NP_001186103.1|refseq:NP_001186104.1|refseq:NP_071767.3|refseq:XP_016879037.1|refseq:XP_016879038.1|dip:DIP-39481N|ensembl:ENSG00000167965(gene)|ensembl:ENST00000397124(transcript)|ensembl:ENST00000564088(transcript)|ensembl:ENST00000565250(transcript)|ensembl:ENST00000569417(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR037588|mint:Q9BVC4|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5H64|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288|entrezgene/locuslink:64223(identity)|refseq:XM_005255480.2(identity)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:BQek96xYe/1IaE8vgX3Uvl9vkCc9606	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	intact-crc:6A7D49C1AD0C5DB0|rigid:PFCZKZDHwDIYbxWdclyrjH68zRw	false	phosphorylated residue:?-?|sufficient binding region:2-289	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96JC1	uniprotkb:P40763-2	intact:EBI-1050197|uniprotkb:O94869|uniprotkb:Q7Z3V3|uniprotkb:Q96B93|uniprotkb:Q96RM0|uniprotkb:Q71SQ6|ensembl:ENSP00000335193	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:vps39_human(display_long)|uniprotkb:KIAA0770(gene name synonym)|uniprotkb:VPS39(gene name)|psi-mi:VPS39(display_short)|uniprotkb:VAM6(gene name synonym)|uniprotkb:TLP(gene name synonym)|uniprotkb:TRAP1-like protein(gene name synonym)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692006|imex:IM-22632-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056104.2|refseq:NP_001288067.1|ensembl:ENSG00000166887(gene)|ensembl:ENST00000348544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:1902501"(lysosomal HOPS complex)|go:"GO:1902774"(late endosome to lysosome transport)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR001180(Citron-like)|interpro:IPR019452|interpro:IPR019453|interpro:IPR032914|rcsb pdb:6ZE9|refseq:NM_015289.3(identity)|entrezgene/locuslink:23339(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	-	isoform-comment:Contains a phosphotyrosine at position 704.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:BeY8ZDCOyTvZqA0WpdWnmz+giYk9606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:C346B1C5D5F38023|rigid:u53/MnD2QnTipHM00E5zREmeZaQ	false	sufficient binding region:170-886|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96A09	uniprotkb:Q9NP31	intact:EBI-752030|ensembl:ENSP00000289166	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:tet5b_human(display_long)|uniprotkb:TENT5B(gene name)|psi-mi:TENT5B(display_short)|uniprotkb:FAM46B(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692027|imex:IM-22632-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443175.2|ensembl:ENSG00000158246(gene)|ensembl:ENST00000289166(transcript)|go:"GO:0048255"(mRNA stabilization)|go:"GO:1990817"(RNA adenylyltransferase activity)|interpro:IPR012937(Protein of unknown function DUF1693)|entrezgene/locuslink:115572(identity)|refseq:NM_052943.3(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:hcI1m66Kt1B5RS3kqXhFmu0lNrg9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:1B54A07F9838E8E9|rigid:y9rQGdkicQ8hFsiLKnWIr3y2iZ8	false	sufficient binding region:2-425|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WUD1	uniprotkb:P46108-2	intact:EBI-5542466|ensembl:ENSP00000380869|uniprotkb:B2RD03|uniprotkb:D3DS24|uniprotkb:Q6NZ33	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:rab2b_human(display_long)|uniprotkb:RAB2B(gene name)|psi-mi:RAB2B(display_short)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692044|imex:IM-22632-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156852.1|ensembl:ENST00000397762(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2A5J|reactome:R-HSA-8873719|ensembl:ENSG00000129472(gene)|refseq:NP_116235.2|refseq:XP_016877200.1|refseq:NM_001163380.1(identity)|entrezgene/locuslink:84932(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:wj76bPe9YR4JnqPm07VAqCa+CqY9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:B0EBEE9544090854|rigid:bSNMJvYMxECftS1bMMca7CB7zMM	false	phosphorylated residue:?-?|sufficient binding region:52-216	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07947	uniprotkb:Q8TAK6	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692087|imex:IM-22632-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439|refseq:NM_005433.3(identity)|entrezgene/locuslink:7525(identity)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FES (P07332), FGR (P09769), HCK (P08631), PTK2 (Q05397), YES1 (P07947)."|comment:"The interaction failed to show if kinase-dead versions of ABL2 (P42684), FES (P07332) or PTK2 (Q05397) were used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	intact-crc:FBE11979540B7575|rigid:dgNIcYQENPkBykm+lSHws4I6Oio	false	phosphorylated residue:?-?	sufficient binding region:17-271|phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TE12	uniprotkb:P62993	intact:EBI-10692065|uniprotkb:Q5VWG4|uniprotkb:Q0VDB5|uniprotkb:B3KXP6|uniprotkb:Q8TE11|ensembl:ENSP00000294816|ensembl:ENSP00000340226|ensembl:ENSP00000356868	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:lmx1a_human(display_long)|uniprotkb:LMX1A(gene name)|psi-mi:LMX1A(display_short)|uniprotkb:LIM/homeobox protein 1.1(gene name synonym)|uniprotkb:LIM/homeobox protein LMX1A(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692061|imex:IM-22632-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001167540.1|refseq:NP_796372.1|go:"GO:0046872"(metal ion binding)|go:"GO:0050808"(synapse organization)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR042688|ensembl:ENSG00000162761(gene)|ensembl:ENST00000294816(transcript)|ensembl:ENST00000342310(transcript)|ensembl:ENST00000367893(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021549"(cerebellum development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0042048"(olfactory behavior)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|entrezgene/locuslink:4009(identity)|refseq:XM_006711319.1(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FER (P16591), FGR (P09769), FYN (P06241), YES1 (P07947)."|comment:"The interaction failed to show if kinase-dead versions of ABL2 (P42684) or FYN (P06241) were used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:1Lm6PRjM5McmrHXC9GVW9zlWvDg9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:A00DC7273C0133BC|rigid:f3Z6f/LfZJFnQXE9fhnRB2QXqRk	false	phosphorylated residue:?-?|sufficient binding region:283-382	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16333	uniprotkb:Q8TAK6	intact:EBI-389883|uniprotkb:B7Z751|ensembl:ENSP00000288986|ensembl:ENSP00000417273|intact:EBI-3448658|uniprotkb:D3DNE3	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	psi-mi:nck1_human(display_long)|uniprotkb:NCK1(gene name)|psi-mi:NCK1(display_short)|uniprotkb:NCK(gene name synonym)|uniprotkb:NCK adaptor protein 1(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-alpha(gene name synonym)	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692105|imex:IM-22632-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278928.1|ensembl:ENSG00000158092(gene)|ensembl:ENST00000288986(transcript)|ensembl:ENST00000481752(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007172"(signal complex assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|refseq:NP_001177725.1|refseq:NP_006144.1|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|mint:P16333|rcsb pdb:2CI8|rcsb pdb:2CI9|rcsb pdb:2CUB|rcsb pdb:2JS0|rcsb pdb:2JS2|rcsb pdb:2JW4|rcsb pdb:5QU1|rcsb pdb:5QU2|rcsb pdb:5QU3|rcsb pdb:5QU4|rcsb pdb:5QU5|rcsb pdb:5QU6|rcsb pdb:5QU7|rcsb pdb:5QU8|rcsb pdb:5QUA|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-373753|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9664422|reactome:R-HSA-983695|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|dip:DIP-639N|entrezgene/locuslink:4690(identity)|refseq:NM_006153.5(identity)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FER (P16591)."|comment:"The interaction failed to show if a kinase-dead version of ABL2 (P42684) was used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:UzgLYRQQ9VjN7eKkgn76At/7cSA9606	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	intact-crc:4E99D3F04EF90C4F|rigid:bFUUmPBJxMtwjssIJlawK+OpkGA	false	phosphorylated residue:?-?	phosphorylated residue:?-?|sufficient binding region:17-271	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14451	uniprotkb:Q8TAK6	intact:EBI-970191|ensembl:ENSP00000310771|ensembl:ENSP00000377759|ensembl:ENSP00000377761|uniprotkb:B2RAV1|uniprotkb:B3KNL0|uniprotkb:B3KWP9|uniprotkb:B7WP75|uniprotkb:Q53YD3|uniprotkb:Q9Y220|uniprotkb:Q92568|uniprotkb:Q96DF9|intact:EBI-1257061|uniprotkb:J3KQM4	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	psi-mi:grb7_human(display_long)|uniprotkb:GRB7(gene name)|psi-mi:GRB7(display_short)|uniprotkb:GRB7 adapter protein(gene name synonym)|uniprotkb:Epidermal growth factor receptor GRB-7(gene name synonym)|uniprotkb:B47(gene name synonym)	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692123|imex:IM-22632-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141738(gene)|ensembl:ENST00000309156(transcript)|ensembl:ENST00000394209(transcript)|ensembl:ENST00000394211(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042995"(cell projection)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035032|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q14451|rcsb pdb:1MW4|rcsb pdb:1WGR|rcsb pdb:2L4K|rcsb pdb:2QMS|rcsb pdb:3PQZ|rcsb pdb:4WWQ|rcsb pdb:4X6S|rcsb pdb:5D0J|rcsb pdb:5EEL|rcsb pdb:5EEQ|rcsb pdb:5TYI|rcsb pdb:5U06|rcsb pdb:5U1Q|go:"GO:0042802"(identical protein binding)|reactome:R-HSA-1306955|reactome:R-HSA-186763|reactome:R-HSA-210993|reactome:R-HSA-8853659|reactome:R-HSA-9696273|reactome:R-HSA-1433557|refseq:NP_001025173.1|refseq:NP_001229371.1|refseq:NP_001229372.1|refseq:NP_005301.2|refseq:NP_001317136.1|dip:DIP-502N|entrezgene/locuslink:2886(identity)|refseq:NM_001030002.2(identity)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FER (P16591)."|comment:"The interaction failed to show if a kinase-dead version of ABL2 (P42684) was used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:XViWZjk5YwdZFTG3zs2aNdxeFVQ9606	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	intact-crc:1AD571F609C32A85|rigid:GebKMHt5elcU4o4cYn+tkSqg0fc	false	phosphorylated residue:?-?	sufficient binding region:17-271|phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20936-2	uniprotkb:Q8TAK6	intact:EBI-10692141|ensembl:ENSP00000411221	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	psi-mi:p20936-2(display_long)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:GAP(gene name synonym)|uniprotkb:RASA(gene name synonym)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:Short(isoform synonym)	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692145|imex:IM-22632-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1026476(isoform-parent)|ensembl:ENSG00000145715(gene)|ensembl:ENST00000456692(transcript)|refseq:NM_022650.2(identity)|entrezgene/locuslink:5921(identity)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FER (P16591), TNK1 (Q13470)."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:gsn+cRWWTGAXoA4zR9yX9mYLn5s9606	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	intact-crc:0476A434D43DD3E1|rigid:ZzhgWs4RXpJWc3k72nFqkMyGzUA	false	phosphorylated residue:?-?	phosphorylated residue:?-?|sufficient binding region:17-271	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TAK6	uniprotkb:P42229	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	intact:EBI-749537|uniprotkb:Q1KLZ6|ensembl:ENSP00000341208|ensembl:ENSP00000468749|ensembl:ENSP00000503262|ensembl:ENSP00000504449	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:sta5a_human(display_long)|uniprotkb:STAT5A(gene name)|psi-mi:STAT5A(display_short)|uniprotkb:STAT5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692162|imex:IM-22632-36	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	refseq:NP_003143.2|refseq:NP_001275647.1|refseq:NP_001275648.1|refseq:NP_001275649.1|dip:DIP-396N|ensembl:ENSG00000126561(gene)|ensembl:ENST00000345506(transcript)|ensembl:ENST00000590949(transcript)|ensembl:ENST00000676585(transcript)|ensembl:ENST00000677301(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42229|reactome:R-HSA-1170546|reactome:R-HSA-1251985|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772|refseq:NM_003152.3(identity)|entrezgene/locuslink:6776(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	rogid:KwM9uGM/He9Ome/Pzi6u/SgC6NY9606	intact-crc:893DD3FDBEE29CC0|rigid:SIFLIL3ZisobfCjHLUDWwGnjvQA	false	sufficient binding region:17-271|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29350-3	uniprotkb:Q8TAK6	intact:EBI-7399369|ensembl:ENSP00000382376|intact:MINT-134096	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	psi-mi:p29350-3(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:PTP1C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692179|imex:IM-22632-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111679(gene)|ensembl:ENST00000399448(transcript)|intact:EBI-78260(isoform-parent)|uniprotkb:P29350-3(isoform-parent)|refseq:NM_080548.4(identity)|entrezgene/locuslink:5777(identity)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	-	comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:dOlpiLWoBar/3ryQxTZss7nQqTs9606	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	intact-crc:D616C6C67F3D5BFC|rigid:nh5NO7sbdg2GUQrXmC+X4nGqzVk	false	phosphorylated residue:?-?	phosphorylated residue:?-?|sufficient binding region:17-271	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZQ1	uniprotkb:P62993	intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692234|imex:IM-22632-40	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N|refseq:NM_014991.4(identity)|entrezgene/locuslink:23001(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:B811B30ED104D24D|rigid:ADQ5EC6mrVV+lARfPHBz/t2Awzw	false	sufficient binding region:3246-3526|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TAK6	uniprotkb:P49757-3	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	intact:EBI-10692196|ensembl:ENSP00000352563|ensembl:ENSP00000451117	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:p49757-3(display_long)|uniprotkb:C14orf41(gene name synonym)|uniprotkb:NUMB(gene name)|psi-mi:NUMB(display_short)|uniprotkb:Protein S171(gene name synonym)|uniprotkb:p71(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692200|imex:IM-22632-38	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	intact:EBI-915016(isoform-parent)|uniprotkb:P49757-3(isoform-parent)|ensembl:ENSG00000133961(gene)|ensembl:ENST00000359560(transcript)|ensembl:ENST00000557597(transcript)|entrezgene/locuslink:8650(identity)|refseq:NM_001005745.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	rogid:N2YwdjNBMiXeMFYxQrJDxqeNkSA9606	intact-crc:BD683368B44D81D3|rigid:KwQRgLy6OwPx9WNd6bS3w7ZTMaA	false	sufficient binding region:17-271|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEU8	uniprotkb:Q8NEZ4	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	intact:EBI-1042997|uniprotkb:Q8NC02|uniprotkb:Q8NDF6|uniprotkb:Q9H9P4|uniprotkb:Q9NR13|uniprotkb:Q9P222|uniprotkb:Q9UDR7|ensembl:ENSP00000262189	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:kmt2c_human(display_long)|uniprotkb:KMT2C(gene name)|psi-mi:KMT2C(display_short)|uniprotkb:HALR(gene name synonym)|uniprotkb:Homologous to ALR protein(gene name synonym)|uniprotkb:KIAA1506(gene name synonym)|uniprotkb:MLL3(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692217|imex:IM-22632-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	ensembl:ENSG00000055609(gene)|ensembl:ENST00000262189(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042393"(histone binding)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0097692"(histone H3-K4 monomethylation)|interpro:IPR000637(HMG-I and HMG-Y, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|go:"GO:0005634"(nucleus)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036910|interpro:IPR037877|interpro:IPR041967|interpro:IPR041968|mint:Q8NEZ4|rcsb pdb:2YSM|rcsb pdb:2YUK|rcsb pdb:3UVL|rcsb pdb:4ERY|rcsb pdb:5F59|rcsb pdb:5F6K|rcsb pdb:6KIW|rcsb pdb:6MLC|reactome:R-HSA-3214841|reactome:R-HSA-5617472|reactome:R-HSA-8936459|refseq:NP_733751.2|ensembl:ENSP00000262189|ensembl:ENST00000682283|ensembl:ENSP00000507485|dip:DIP-48649N|entrezgene/locuslink:58508(identity)|refseq:NM_170606.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	rogid:NZg8HgfbohMT8EEgAdAgWR1AjSo9606	intact-crc:E3EB87961ED3C5FF|rigid:NEqfojpk+JJhzbR44AHnByHeH+8	false	phosphorylated residue:?-?	phosphorylated residue:?-?|sufficient binding region:37-356	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5R372-2	uniprotkb:Q8IZQ1	intact:EBI-10692254|ensembl:ENSP00000350027	intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692251|imex:IM-22632-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N|refseq:NM_014991.4(identity)|entrezgene/locuslink:23001(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606	intact-crc:AEB05D8339361465|rigid:VzVtsQelsn1zTXFO3MIa7+rDOGE	false	phosphorylated residue:?-?	sufficient binding region:3246-3526|phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZQ1	uniprotkb:P40763	intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692272|imex:IM-22632-42	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N|refseq:NM_014991.4(identity)|entrezgene/locuslink:23001(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:DC5711AE4EF57E5D|rigid:g0CGpe0D+y9jus/7GcA3GSvbegE	false	phosphorylated residue:?-?|sufficient binding region:3246-3526	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IXK0	uniprotkb:P46108-2	intact:EBI-713786|uniprotkb:Q8N306|uniprotkb:Q8TAG8|uniprotkb:A1L4Q1|uniprotkb:Q2TAL3|uniprotkb:Q5T0C1|uniprotkb:Q6NUJ6|uniprotkb:Q6ZQR1|uniprotkb:Q96BL4|uniprotkb:Q9Y4Y7|ensembl:ENSP00000257118|uniprotkb:D3DPR2|uniprotkb:A8KA40	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:phc2_human(display_long)|uniprotkb:Early development regulatory protein 2(gene name synonym)|uniprotkb:PHC2(gene name)|psi-mi:PHC2(display_short)|uniprotkb:EDR2(gene name synonym)|uniprotkb:PH2(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692289|imex:IM-22632-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR038603|mint:Q8IXK0|reactome:R-HSA-2559580|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-8939243|reactome:R-HSA-8943724|interpro:IPR013761(Sterile alpha motif-type)|ensembl:ENSG00000134686(gene)|ensembl:ENST00000257118(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR012313(Zinc finger, FCS-type)|refseq:NP_004418.2|refseq:NP_932157.1|refseq:XP_016856005.1|refseq:XP_016856006.1|refseq:XP_016856007.1|refseq:XP_005270627.1|dip:DIP-34464N|refseq:NM_004427.3(identity)|entrezgene/locuslink:1912(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:7si/KU2tHoxviuCr70ncQERDWmY9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:E8FF522E6F2523A7|rigid:rweX3ifXQKh4XcxvdE90M+rBsWQ	false	sufficient binding region:536-858|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZVU3	uniprotkb:P40763	intact:EBI-10692309	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:q6zvu3_human(display_long)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692306|imex:IM-22632-44	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000980(SH2 motif)|go:"GO:0007165"(signal transduction)|interpro:IPR035847|interpro:IPR035848|interpro:IPR036860|entrezgene/locuslink:6452(identity)|refseq:XM_006713911.1(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:aXLhmmekzxHm9dx2GYbVhkLRFG89606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:367968353667D747|rigid:RJy+ItFSSW6XVi1+Acs0qj1EgGA	false	sufficient binding region:204-431|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:Q6P1L5	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-3893327|uniprotkb:Q53QZ5|uniprotkb:Q585T9|uniprotkb:Q8N8W1|uniprotkb:Q96Q34|ensembl:ENSP00000376071	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:f117b_human(display_long)|uniprotkb:FAM117B(gene name)|psi-mi:FAM117B(display_short)|uniprotkb:ALS2CR13(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692347|imex:IM-22632-46	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_775782.2|ensembl:ENST00000392238(transcript)|interpro:IPR026641|interpro:IPR026642|mint:Q6P1L5|ensembl:ENSG00000138439(gene)|entrezgene/locuslink:150864(identity)|refseq:NM_173511.3(identity)	-	crc64:6C00632211C8012D	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:ADo2dQPS1oosYCBJSZHY8jHcjeA9606	intact-crc:987EC781E8435C04|rigid:8vasp6NgoPJhvrBJp6E2u98zY24	false	phosphorylated residue:?-?	phosphorylated residue:?-?|sufficient binding region:245-589	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:Q6P5X5-2	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-10692329	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:q6p5x5-2(display_long)|uniprotkb:C22orf39(gene name)|psi-mi:C22orf39(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692326|imex:IM-22632-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	intact:EBI-7317823(isoform-parent)|uniprotkb:Q6P5X5-2(isoform-parent)|entrezgene/locuslink:128977(identity)|refseq:NM_001166242.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FRK (P42685), PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:RP5uK3PNbCaJZBS4IFuGCkMdqqk9606	intact-crc:396B13E88EC40749|rigid:kL/IRlnv36Uo32itFNCCtlmm8ig	false	phosphorylated residue:?-?	phosphorylated residue:?-?|sufficient binding region:38-117	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q66PJ3-4	uniprotkb:Q92569	intact:EBI-5280499	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:q66pj3-4(display_long)|uniprotkb:Splicing factor SRrp37(gene name synonym)|uniprotkb:ARL6IP4(gene name)|psi-mi:ARL6IP4(display_short)|uniprotkb:HSP-975(gene name synonym)|uniprotkb:HSVI-binding protein(gene name synonym)|uniprotkb:SR-15(gene name synonym)|uniprotkb:SRp25(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692364|imex:IM-22632-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2683099(isoform-parent)|uniprotkb:Q66PJ3-4(isoform-parent)|entrezgene/locuslink:51329(identity)|refseq:NM_001002252.2(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), LYN (P07948), YES1 (P07947)."|comment:"The interaction failed to show if a kinase-dead version of FYN (P06241) was used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:XZT/eX9V6PNVyIyUg7RvZpH0Ydg9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:43D480177BA66C6D|rigid:mCY4QnCt4aqMHLGj3Yv+CkaHsT0	false	sufficient binding region:185-399|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5VWN6	uniprotkb:P40763-2	intact:EBI-745958|uniprotkb:Q2YD91|uniprotkb:Q5VWN5|uniprotkb:Q6ZRQ8|uniprotkb:Q8IVG4|uniprotkb:Q9BUZ7|uniprotkb:Q9H5J9|uniprotkb:Q9H7A4|uniprotkb:Q9H996|uniprotkb:Q9NXA1|intact:EBI-28974916|ensembl:ENSP00000328426	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:taso2_human(display_long)|uniprotkb:TASOR2(gene name)|psi-mi:TASOR2(display_short)|uniprotkb:C10orf18(gene name synonym)|uniprotkb:FAM208B(gene name synonym)|uniprotkb:KIAA2006(gene name synonym)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692382|imex:IM-22632-48	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060252.4|ensembl:ENSP00000328426|refseq:XP_011517827.1|refseq:XP_016871852.1|refseq:XP_016871854.1|ensembl:ENSG00000108021(gene)|ensembl:ENST00000328090(transcript)|go:"GO:0005829"(cytosol)|interpro:IPR022168|interpro:IPR022188|mint:Q5VWN6|go:"GO:0005654"(nucleoplasm)|refseq:XP_005252532.1|refseq:XP_005252537.1|refseq:XP_005252538.1|refseq:XP_005252539.1|refseq:NP_001308712.1|refseq:NP_001308713.1|refseq:NP_001308714.1|entrezgene/locuslink:54906(identity)|refseq:NM_017782.4(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	-	isoform-comment:Contains a phosphotyrosine at position 704.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:mTRMzWB45dZojaB1ZrsaQRT48YQ9606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:6C969CB9024A2584|rigid:AFKvuXLNDpwSG6WqUQDcDDKW4G4	false	phosphorylated residue:?-?|sufficient binding region:1690-2430	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5VWN6	uniprotkb:P40763	intact:EBI-745958|uniprotkb:Q2YD91|uniprotkb:Q5VWN5|uniprotkb:Q6ZRQ8|uniprotkb:Q8IVG4|uniprotkb:Q9BUZ7|uniprotkb:Q9H5J9|uniprotkb:Q9H7A4|uniprotkb:Q9H996|uniprotkb:Q9NXA1|intact:EBI-28974916|ensembl:ENSP00000328426	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:taso2_human(display_long)|uniprotkb:TASOR2(gene name)|psi-mi:TASOR2(display_short)|uniprotkb:C10orf18(gene name synonym)|uniprotkb:FAM208B(gene name synonym)|uniprotkb:KIAA2006(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692399|imex:IM-22632-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060252.4|ensembl:ENSP00000328426|refseq:XP_011517827.1|refseq:XP_016871852.1|refseq:XP_016871854.1|ensembl:ENSG00000108021(gene)|ensembl:ENST00000328090(transcript)|go:"GO:0005829"(cytosol)|interpro:IPR022168|interpro:IPR022188|mint:Q5VWN6|go:"GO:0005654"(nucleoplasm)|refseq:XP_005252532.1|refseq:XP_005252537.1|refseq:XP_005252538.1|refseq:XP_005252539.1|refseq:NP_001308712.1|refseq:NP_001308713.1|refseq:NP_001308714.1|entrezgene/locuslink:54906(identity)|refseq:NM_017782.4(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:mTRMzWB45dZojaB1ZrsaQRT48YQ9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:05ED7D66D8DEE8EA|rigid:Y4yKrmRBRbnp9YjCK9wqm3XXnTY	false	sufficient binding region:1690-2430|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5SXH7-1	uniprotkb:P62993	intact:EBI-26412802	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:q5sxh7-1(display_long)|uniprotkb:PLEKHS1(gene name)|psi-mi:PLEKHS1(display_short)|uniprotkb:C10orf81(gene name synonym)|uniprotkb:Epididymis luminal protein 185(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692416|imex:IM-22632-50	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-10691507(isoform-parent)|entrezgene/locuslink:79949(identity)|refseq:XM_005270162.2(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), SRC (P12931), SYK (P43405), TNK1 (Q13470), YES1 (P07947)."|comment:"The interaction failed to show if kinase-dead versions of ABL2 (P42684), TNK1 (Q13470) or FYN (P06241) were used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2020/10/22	rogid:8OuCSDcvw9rtC0JZC596NetxIKA9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:0E0F42E34FBAB015|rigid:NnbEecG1Kp3JPn2xdnbmM2cu0ZU	false	sufficient binding region:181-462|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q53HF2	uniprotkb:O14796	intact:EBI-877761	intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906	psi-mi:q53hf2_human(display_long)	psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692434|imex:IM-22632-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|refseq:NP_006588.1|refseq:NP_694881.1|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR043129|refseq:NM_153201.3(identity)|entrezgene/locuslink:3303(identity)	refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933|entrezgene/locuslink:117157(identity)|refseq:NM_053282.4(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), BMX (P51813), FGR (P09769), FYN (P06241), HCK (P08631), SRC (P12931), TNK1 (Q13470), YES1 (P07947)."|comment:"The interaction failed to show if kinase-dead versions of ABL2 (P42684) or FYN (P06241) were used."|figure legend:Suppl. table S3, suppl .fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:m6Qk8kbAwVk7YILzmsVDpzKHUvE9606	rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606	intact-crc:D5D24C0B6343EDAA|rigid:4XU6qktSmuvuPHcfeP+LX8pbcUQ	false	sufficient binding region:12-203|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q49A88	uniprotkb:Q92569	intact:EBI-751035|intact:EBI-2622203|intact:EBI-2858142|uniprotkb:B7Z2T2|uniprotkb:B8ZZ58|intact:EBI-946963|intact:EBI-1104778|uniprotkb:Q7Z3N3|uniprotkb:Q86T30|uniprotkb:Q8WUJ8|uniprotkb:Q96K47|uniprotkb:Q9H9A3|uniprotkb:Q9UFH0|uniprotkb:Q8IWF8|uniprotkb:B8ZZ41|uniprotkb:D3DN98|uniprotkb:B7Z2Q3	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:ccd14_human(display_long)|uniprotkb:CCDC14(gene name)|psi-mi:CCDC14(display_short)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692452|imex:IM-22632-52	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_073594.4|refseq:NP_001295246.1|refseq:XP_005247767.1|refseq:XP_005247768.1|refseq:XP_005247770.1|refseq:XP_005247771.1|refseq:XP_016862545.1|refseq:XP_016862547.1|refseq:XP_016862548.1|mint:Q49A88|dip:DIP-47727N|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0021762"(substantia nigra development)|go:"GO:0034451"(centriolar satellite)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR029343|entrezgene/locuslink:64770(identity)|refseq:XM_005247714.2(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), SYK (P43405), YES1 (P07947)."|comment:"The interaction failed to show if kinase-dead versions of ABL2 (P42684), FYN (P06241) or SYK (P43405) were used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:y1bU4io/NA6LIX+pwRkB8gstVuY9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:FA8B68222C1A8C41|rigid:Wh0k/o5KZ3O0oMoO9HL3lUDQdE0	false	phosphorylated residue:?-?|sufficient binding region:201-953	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:Q15389-2	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-10692491|ensembl:ENSP00000297450	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:q15389-2(display_long)|uniprotkb:ANGPT1(gene name)|psi-mi:ANGPT1(display_short)|uniprotkb:KIAA0003(gene name synonym)|uniprotkb:Gly-269 del(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692488|imex:IM-22632-54	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	ensembl:ENSG00000154188(gene)|ensembl:ENST00000297450(transcript)|intact:EBI-2922365(isoform-parent)|entrezgene/locuslink:284(identity)|refseq:NM_001199859.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FRK (P42685), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:5Upmh3KuCcINYHtPCexkVUarKPw9606	intact-crc:2CEEBE23094C3425|rigid:t8VXeUmQHfGBMJcztWFm8VlzdwU	false	phosphorylated residue:?-?	sufficient binding region:255-401|phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q32MZ4-4	uniprotkb:Q9NP31	intact:EBI-10240044|ensembl:ENSP00000310109	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:q32mz4-4(display_long)|uniprotkb:GC-binding factor 2(gene name synonym)|uniprotkb:GCF2(gene name synonym)|uniprotkb:TAR RNA-interacting protein(gene name synonym)|uniprotkb:TRIP(gene name synonym)|uniprotkb:LRRFIP1(gene name)|psi-mi:LRRFIP1(display_short)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692470|imex:IM-22632-53	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1369100(isoform-parent)|ensembl:ENSG00000124831(gene)|ensembl:ENST00000308482(transcript)|entrezgene/locuslink:9208(identity)|refseq:NM_001137551.1(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), CSK (P41240), FER (P16591), FGR (P09769), FYN (P06241), JAK3 (P52333)."|comment:"The interaction failed to show if kinase-dead versions of ABL2 (P42684) or FYN (P06241) were used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:BBw6Zm3Kb8c4Jq9DUR6+QwjJXzM9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:98A1ED23A6DC889D|rigid:1KWtYNU/MAvV8XmKuuYX11SmNA0	false	sufficient binding region:536-640|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WXH5	uniprotkb:Q07912	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	intact:EBI-603457|intact:EBI-1384159|uniprotkb:Q6ZMQ0|uniprotkb:Q8N6U7|uniprotkb:Q96H59|ensembl:ENSP00000329425	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:ack1_human(display_long)|uniprotkb:ACK1(gene name synonym)|uniprotkb:TNK2(gene name)|psi-mi:TNK2(display_short)|uniprotkb:Tyrosine kinase non-receptor protein 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692509|imex:IM-22632-55	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	ensembl:ENSP00000329425|ensembl:ENST00000439230|ensembl:ENSP00000395588|ensembl:ENST00000671753|ensembl:ENSP00000499858|ensembl:ENSG00000061938(gene)|ensembl:ENST00000333602(transcript)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006897"(endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050699"(WW domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0097268"(cytoophidium)|go:"GO:0106310"(protein serine kinase activity)|refseq:NP_001010938.1|refseq:NP_005772.3|refseq:NP_001294975.1|dip:DIP-33858N|go:"GO:0106311"|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015116(GTPase binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR021619|interpro:IPR030220|interpro:IPR036028|interpro:IPR037085|mint:Q07912|rcsb pdb:1CF4|rcsb pdb:1U46|rcsb pdb:1U4D|rcsb pdb:1U54|rcsb pdb:3EQP|rcsb pdb:3EQR|rcsb pdb:4EWH|rcsb pdb:4HZR|rcsb pdb:4HZS|rcsb pdb:4ID7|rcsb pdb:5ZXB|rcsb pdb:6VQM|entrezgene/locuslink:10188(identity)|refseq:XM_006713468.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813), FRK (P42685), PTK2 (Q05397), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	rogid:AD7D+7w6zZOL3VHmf23YSk6NW2w9606	intact-crc:9637B1E9E381A570|rigid:uw0zJDIIJNyH7sH/ep1PzokcQX4	false	phosphorylated residue:?-?	phosphorylated residue:?-?|sufficient binding region:1-484	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07869	uniprotkb:P62993	intact:EBI-78615|uniprotkb:Q16241|uniprotkb:Q92486|uniprotkb:Q92689|uniprotkb:Q9Y3N1|ensembl:ENSP00000262735|ensembl:ENSP00000385246|ensembl:ENSP00000385523|uniprotkb:Q6I9S0|uniprotkb:B0G0X3	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:ppara_human(display_long)|uniprotkb:PPARA(gene name)|psi-mi:PPARA(display_short)|uniprotkb:NR1C1(gene name synonym)|uniprotkb:PPAR(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group C member 1(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692526|imex:IM-22632-56	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_005261712.1|refseq:XP_005261713.1|ensembl:ENSG00000186951(gene)|ensembl:ENST00000262735(transcript)|ensembl:ENST00000402126(transcript)|ensembl:ENST00000407236(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008544"(epidermis development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010876"(lipid localization)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033993"(response to lipid)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070166"(enamel mineralization)|go:"GO:0045471"(response to ethanol)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|rcsb pdb:1I7G|go:"GO:0097371"(MDM2/MDM4 family protein binding)|rcsb pdb:1K7L|rcsb pdb:1KKQ|rcsb pdb:2NPA|rcsb pdb:2P54|rcsb pdb:2REW|rcsb pdb:2ZNN|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:2000191"(regulation of fatty acid transport)|go:"GO:2000272"(negative regulation of signaling receptor activity)|rcsb pdb:3ET1|rcsb pdb:3FEI|rcsb pdb:3G8I|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003074(Peroxisome proliferator-activated receptor)|interpro:IPR003076(Peroxisome proliferator-activated receptor, alpha)|rcsb pdb:3KDT|interpro:IPR013088(Zinc finger, NHR/GATA-type)|rcsb pdb:3KDU|interpro:IPR035500|mint:Q07869|rcsb pdb:3SP6|rcsb pdb:3VI8|rcsb pdb:4BCR|rcsb pdb:4CI4|reactome:R-HSA-1989781|rcsb pdb:5AZT|reactome:R-HSA-2151201|reactome:R-HSA-2426168|rcsb pdb:5HYK|rcsb pdb:6KAX|reactome:R-HSA-381340|rcsb pdb:6KAY|rcsb pdb:6KAZ|reactome:R-HSA-383280|rcsb pdb:6KB0|reactome:R-HSA-400206|rcsb pdb:6KB1|rcsb pdb:6KB2|rcsb pdb:6KB3|rcsb pdb:6KB4|rcsb pdb:6KB5|reactome:R-HSA-400253|reactome:R-HSA-4090294|rcsb pdb:6KB6|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:6KB7|rcsb pdb:6KB8|rcsb pdb:6KB9|rcsb pdb:6KBA|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6KYP|rcsb pdb:6L36|rcsb pdb:6L37|rcsb pdb:6L38|rcsb pdb:6L96|rcsb pdb:6LX4|rcsb pdb:6LX5|rcsb pdb:6LX6|rcsb pdb:6LX7|rcsb pdb:6LX8|rcsb pdb:6LX9|rcsb pdb:6LXA|rcsb pdb:6LXB|rcsb pdb:6LXC|rcsb pdb:7BPY|rcsb pdb:7BPZ|rcsb pdb:7BQ0|rcsb pdb:7BQ1|rcsb pdb:7BQ2|rcsb pdb:7BQ3|rcsb pdb:7BQ4|rcsb pdb:7C6Q|reactome:R-HSA-1368082|reactome:R-HSA-1368108|refseq:NP_001001928.1|refseq:NP_005027.2|refseq:XP_011528541.1|refseq:XP_011528542.1|refseq:XP_011528543.1|refseq:XP_011528544.1|refseq:XP_011528545.1|refseq:XP_006724332.1|refseq:XP_006724333.1|dip:DIP-241N|refseq:XM_006724271.1(identity)|entrezgene/locuslink:5465(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FRK (P42685), FYN (P06241)."|comment:"The interaction failed to show if kinase-dead versions of FRK (P42685) or FYN (P06241) were used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:0ZZ5eL0cNC8OgOvd8spQ5ypBvAo9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:4F7D85A8191F28BC|rigid:zTvRdTBXirQk9l7jXtSGw+bNfpM	false	sufficient binding region:1-237|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07869	uniprotkb:Q92569	intact:EBI-78615|uniprotkb:Q16241|uniprotkb:Q92486|uniprotkb:Q92689|uniprotkb:Q9Y3N1|ensembl:ENSP00000262735|ensembl:ENSP00000385246|ensembl:ENSP00000385523|uniprotkb:Q6I9S0|uniprotkb:B0G0X3	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:ppara_human(display_long)|uniprotkb:PPARA(gene name)|psi-mi:PPARA(display_short)|uniprotkb:NR1C1(gene name synonym)|uniprotkb:PPAR(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group C member 1(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692544|imex:IM-22632-57	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_005261712.1|refseq:XP_005261713.1|ensembl:ENSG00000186951(gene)|ensembl:ENST00000262735(transcript)|ensembl:ENST00000402126(transcript)|ensembl:ENST00000407236(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008544"(epidermis development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010876"(lipid localization)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033993"(response to lipid)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070166"(enamel mineralization)|go:"GO:0045471"(response to ethanol)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|rcsb pdb:1I7G|go:"GO:0097371"(MDM2/MDM4 family protein binding)|rcsb pdb:1K7L|rcsb pdb:1KKQ|rcsb pdb:2NPA|rcsb pdb:2P54|rcsb pdb:2REW|rcsb pdb:2ZNN|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:2000191"(regulation of fatty acid transport)|go:"GO:2000272"(negative regulation of signaling receptor activity)|rcsb pdb:3ET1|rcsb pdb:3FEI|rcsb pdb:3G8I|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003074(Peroxisome proliferator-activated receptor)|interpro:IPR003076(Peroxisome proliferator-activated receptor, alpha)|rcsb pdb:3KDT|interpro:IPR013088(Zinc finger, NHR/GATA-type)|rcsb pdb:3KDU|interpro:IPR035500|mint:Q07869|rcsb pdb:3SP6|rcsb pdb:3VI8|rcsb pdb:4BCR|rcsb pdb:4CI4|reactome:R-HSA-1989781|rcsb pdb:5AZT|reactome:R-HSA-2151201|reactome:R-HSA-2426168|rcsb pdb:5HYK|rcsb pdb:6KAX|reactome:R-HSA-381340|rcsb pdb:6KAY|rcsb pdb:6KAZ|reactome:R-HSA-383280|rcsb pdb:6KB0|reactome:R-HSA-400206|rcsb pdb:6KB1|rcsb pdb:6KB2|rcsb pdb:6KB3|rcsb pdb:6KB4|rcsb pdb:6KB5|reactome:R-HSA-400253|reactome:R-HSA-4090294|rcsb pdb:6KB6|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:6KB7|rcsb pdb:6KB8|rcsb pdb:6KB9|rcsb pdb:6KBA|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6KYP|rcsb pdb:6L36|rcsb pdb:6L37|rcsb pdb:6L38|rcsb pdb:6L96|rcsb pdb:6LX4|rcsb pdb:6LX5|rcsb pdb:6LX6|rcsb pdb:6LX7|rcsb pdb:6LX8|rcsb pdb:6LX9|rcsb pdb:6LXA|rcsb pdb:6LXB|rcsb pdb:6LXC|rcsb pdb:7BPY|rcsb pdb:7BPZ|rcsb pdb:7BQ0|rcsb pdb:7BQ1|rcsb pdb:7BQ2|rcsb pdb:7BQ3|rcsb pdb:7BQ4|rcsb pdb:7C6Q|reactome:R-HSA-1368082|reactome:R-HSA-1368108|refseq:NP_001001928.1|refseq:NP_005027.2|refseq:XP_011528541.1|refseq:XP_011528542.1|refseq:XP_011528543.1|refseq:XP_011528544.1|refseq:XP_011528545.1|refseq:XP_006724332.1|refseq:XP_006724333.1|dip:DIP-241N|refseq:XM_006724271.1(identity)|entrezgene/locuslink:5465(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FER (P16591), FGR (P09769), FRK (P42685), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:0ZZ5eL0cNC8OgOvd8spQ5ypBvAo9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:308ADB132D722711|rigid:qNWT3WTApUjeir+Fgq3I8E/dEac	false	sufficient binding region:1-237|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49757	uniprotkb:P35568	intact:EBI-915016|uniprotkb:Q6NUQ7|uniprotkb:Q86SY1|uniprotkb:Q8WW73|uniprotkb:Q9UBG1|uniprotkb:Q9UEQ4|uniprotkb:Q9UKE8|uniprotkb:Q9UKE9|uniprotkb:Q9UKF0|uniprotkb:Q9UQJ4|uniprotkb:B4E2B1|uniprotkb:B1P2N7|uniprotkb:B1P2N8|uniprotkb:B1P2N9|uniprotkb:B1P2N5|uniprotkb:B1P2N6|intact:EBI-28966915|ensembl:ENSP00000347169|ensembl:ENSP00000451300	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	psi-mi:numb_human(display_long)|uniprotkb:Protein S171(gene name synonym)|uniprotkb:NUMB(gene name)|psi-mi:NUMB(display_short)|uniprotkb:C14orf41(gene name synonym)	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692561|imex:IM-22632-58	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000554521|ensembl:ENSP00000450817|ensembl:ENST00000554546|ensembl:ENSP00000452416|ensembl:ENSP00000451300|ensembl:ENST00000555394|ensembl:ENSP00000451625|ensembl:ENST00000555738|ensembl:ENSP00000452069|ensembl:ENST00000557597|ensembl:ENSP00000451117|ensembl:ENST00000559312|ensembl:ENSP00000452888|ensembl:ENST00000560335|ensembl:ENSP00000453209|ensembl:ENSP00000347169|ensembl:ENST00000356296|ensembl:ENSP00000348644|ensembl:ENST00000359560|ensembl:ENSP00000352563|ensembl:ENST00000535282|ensembl:ENSP00000441258|ensembl:ENST00000544991|ensembl:ENSP00000446001|refseq:NP_001307043.1|refseq:NP_001005743.1|refseq:NP_001005744.1|refseq:NP_001005745.1|refseq:NP_003735.3|dip:DIP-37981N|ensembl:ENSG00000133961(gene)|ensembl:ENST00000355058(transcript)|ensembl:ENST00000555238(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021849"(neuroblast division in subventricular zone)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0034332"(adherens junction organization)|go:"GO:0045177"(apical part of cell)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)|mint:P49757|rcsb pdb:5NJJ|rcsb pdb:5NJK|reactome:R-HSA-2122948|reactome:R-HSA-437239|reactome:R-HSA-5610780|reactome:R-HSA-5632684|entrezgene/locuslink:8650(identity)|refseq:XM_006720296.1(identity)	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772|refseq:NM_005544.2(identity)|entrezgene/locuslink:3667(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FRK (P42685), FYN (P06241), HCK (P08631), PTK2 (Q05397), SRC (P12931), TNK1 (Q13470), YES1 (P07947)."|comment:"The interaction failed to show if kinase-dead versions of FYN (P06241), ABL2 (P42684), FRK (P42685), PTK2 (Q05397) or TNK1 (Q13470) were used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:X+CHBhp67o6ROnf86RCtXlCAaF49606	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	intact-crc:2ED85224A845608D|rigid:gEzyvtKT7PblhpFKAcc2sN2Vmls	false	phosphorylated residue:?-?|sufficient binding region:517-651	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49757	uniprotkb:O43559	intact:EBI-915016|uniprotkb:Q6NUQ7|uniprotkb:Q86SY1|uniprotkb:Q8WW73|uniprotkb:Q9UBG1|uniprotkb:Q9UEQ4|uniprotkb:Q9UKE8|uniprotkb:Q9UKE9|uniprotkb:Q9UKF0|uniprotkb:Q9UQJ4|uniprotkb:B4E2B1|uniprotkb:B1P2N7|uniprotkb:B1P2N8|uniprotkb:B1P2N9|uniprotkb:B1P2N5|uniprotkb:B1P2N6|intact:EBI-28966915|ensembl:ENSP00000347169|ensembl:ENSP00000451300	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	psi-mi:numb_human(display_long)|uniprotkb:Protein S171(gene name synonym)|uniprotkb:NUMB(gene name)|psi-mi:NUMB(display_short)|uniprotkb:C14orf41(gene name synonym)	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692579|imex:IM-22632-59	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000554521|ensembl:ENSP00000450817|ensembl:ENST00000554546|ensembl:ENSP00000452416|ensembl:ENSP00000451300|ensembl:ENST00000555394|ensembl:ENSP00000451625|ensembl:ENST00000555738|ensembl:ENSP00000452069|ensembl:ENST00000557597|ensembl:ENSP00000451117|ensembl:ENST00000559312|ensembl:ENSP00000452888|ensembl:ENST00000560335|ensembl:ENSP00000453209|ensembl:ENSP00000347169|ensembl:ENST00000356296|ensembl:ENSP00000348644|ensembl:ENST00000359560|ensembl:ENSP00000352563|ensembl:ENST00000535282|ensembl:ENSP00000441258|ensembl:ENST00000544991|ensembl:ENSP00000446001|refseq:NP_001307043.1|refseq:NP_001005743.1|refseq:NP_001005744.1|refseq:NP_001005745.1|refseq:NP_003735.3|dip:DIP-37981N|ensembl:ENSG00000133961(gene)|ensembl:ENST00000355058(transcript)|ensembl:ENST00000555238(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021849"(neuroblast division in subventricular zone)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0034332"(adherens junction organization)|go:"GO:0045177"(apical part of cell)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)|mint:P49757|rcsb pdb:5NJJ|rcsb pdb:5NJK|reactome:R-HSA-2122948|reactome:R-HSA-437239|reactome:R-HSA-5610780|reactome:R-HSA-5632684|entrezgene/locuslink:8650(identity)|refseq:XM_006720296.1(identity)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:X+CHBhp67o6ROnf86RCtXlCAaF49606	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	intact-crc:152AC35CFEA6EE20|rigid:/rYK0DK3uDFykUS3VLBPKpfrE8c	false	sufficient binding region:517-651|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49137	uniprotkb:P40763	intact:EBI-993299|uniprotkb:Q8IYD6|uniprotkb:Q5SY30|uniprotkb:Q5SY41|ensembl:ENSP00000356070	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:mapk2_human(display_long)|uniprotkb:MAPKAPK2(gene name)|psi-mi:MAPKAPK2(display_short)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692596|imex:IM-22632-60	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENSG00000162889(gene)|ensembl:ENST00000367103(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048839"(inner ear development)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:P49137|rcsb pdb:1KWP|rcsb pdb:1NXK|rcsb pdb:1NY3|rcsb pdb:2JBO|rcsb pdb:2JBP|rcsb pdb:2OKR|rcsb pdb:2ONL|rcsb pdb:2OZA|rcsb pdb:2P3G|rcsb pdb:2PZY|rcsb pdb:3A2C|rcsb pdb:3FPM|rcsb pdb:3FYJ|rcsb pdb:3FYK|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450302|rcsb pdb:3GOK|rcsb pdb:3KA0|rcsb pdb:3KC3|rcsb pdb:3KGA|rcsb pdb:3M2W|rcsb pdb:3M42|rcsb pdb:3R2B|rcsb pdb:3R2Y|rcsb pdb:3R30|rcsb pdb:3WI6|rcsb pdb:4TYH|rcsb pdb:6T8X|rcsb pdb:6TCA|reactome:R-HSA-171007|reactome:R-HSA-199920|reactome:R-HSA-2142691|reactome:R-HSA-2559580|reactome:R-HSA-3371453|reactome:R-HSA-4420097|refseq:NP_004750.1|refseq:NP_116584.2|dip:DIP-35671N|entrezgene/locuslink:9261(identity)|refseq:NM_032960.3(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:iOzgeWqkVeJtasBfXoF50t7R2dE9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:87055F445701A390|rigid:9WfFWgzig2FhxE+gSU4f7/0su2w	false	phosphorylated residue:?-?|sufficient binding region:290-400	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15530	uniprotkb:O95704	intact:EBI-717097|uniprotkb:Q8IV52|uniprotkb:Q9BRD5|uniprotkb:Q6FI20|uniprotkb:H0Y4Z0|uniprotkb:Q59EH6|intact:EBI-28968232|ensembl:ENSP00000344220	intact:EBI-286427|uniprotkb:Q9NYX6|uniprotkb:Q9NYX7|uniprotkb:Q08AG4|uniprotkb:Q9NYX8|uniprotkb:B3KQN9|uniprotkb:Q96Q18|uniprotkb:Q9BYD4|ensembl:ENSP00000350171	psi-mi:pdpk1_human(display_long)|uniprotkb:PDPK1(gene name)|psi-mi:PDPK1(display_short)|uniprotkb:PDK1(gene name synonym)	psi-mi:apbb3_human(display_long)|uniprotkb:Protein Fe65-like 2(gene name synonym)|uniprotkb:APBB3(gene name)|psi-mi:APBB3(display_short)|uniprotkb:FE65L2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692613|imex:IM-22632-61	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002604.1|refseq:NP_112558.2|ensembl:ENST00000268673|ensembl:ENSP00000268673|ensembl:ENSP00000344220|ensembl:ENST00000441549|ensembl:ENSP00000395357|refseq:NP_001248745.1|ensembl:ENSG00000140992(gene)|ensembl:ENST00000342085(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|rcsb pdb:1H1W|rcsb pdb:1OKY|rcsb pdb:1OKZ|rcsb pdb:1UU3|rcsb pdb:1UU7|rcsb pdb:1UU8|rcsb pdb:1UU9|rcsb pdb:1UVR|rcsb pdb:1W1G|rcsb pdb:1W1H|rcsb pdb:1Z5M|rcsb pdb:2BIY|rcsb pdb:2PE0|rcsb pdb:2PE1|rcsb pdb:2PE2|rcsb pdb:2R7B|rcsb pdb:2VKI|rcsb pdb:2XCH|rcsb pdb:2XCK|rcsb pdb:3H9O|rcsb pdb:3HRC|rcsb pdb:3HRF|rcsb pdb:3ION|rcsb pdb:3IOP|rcsb pdb:3NAX|rcsb pdb:3NAY|rcsb pdb:3NUN|rcsb pdb:3NUS|rcsb pdb:3NUU|rcsb pdb:3NUY|rcsb pdb:3ORX|rcsb pdb:3ORZ|rcsb pdb:3OTU|rcsb pdb:1W1D|rcsb pdb:3PWY|rcsb pdb:3QC4|rcsb pdb:3QCQ|rcsb pdb:3QCS|rcsb pdb:3QCX|rcsb pdb:3QCY|rcsb pdb:3QD0|rcsb pdb:3QD3|rcsb pdb:3QD4|rcsb pdb:3RCJ|rcsb pdb:3RWP|rcsb pdb:3RWQ|rcsb pdb:3SC1|rcsb pdb:4A06|rcsb pdb:4A07|rcsb pdb:4AW0|rcsb pdb:4AW1|rcsb pdb:4CT1|rcsb pdb:4CT2|rcsb pdb:4RQK|rcsb pdb:4RQV|rcsb pdb:4RRV|rcsb pdb:4XX9|rcsb pdb:5ACK|rcsb pdb:5HKM|rcsb pdb:5HNG|rcsb pdb:5HO7|rcsb pdb:5HO8|rcsb pdb:5LVL|rcsb pdb:5LVM|rcsb pdb:5LVN|rcsb pdb:5LVO|rcsb pdb:5LVP|rcsb pdb:5MRD|rcsb pdb:6WJQ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-165158|reactome:R-HSA-202424|reactome:R-HSA-2730905|reactome:R-HSA-2871837|reactome:R-HSA-354192|reactome:R-HSA-389357|reactome:R-HSA-392451|reactome:R-HSA-444257|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5625740|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-9634635|dip:DIP-38372N|entrezgene/locuslink:5170(identity)|refseq:NM_031268.5(identity)	refseq:NP_006042.3|refseq:NP_573418.2|refseq:NP_573419.2|refseq:NP_573420.2|ensembl:ENSG00000113108(gene)|ensembl:ENST00000357560(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036020|interpro:IPR039576|rcsb pdb:2DYQ|rcsb pdb:2YSC|entrezgene/locuslink:10307(identity)|refseq:NM_133173.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:1Uf7b8GptL7XBfEZm43zB3ho6ZQ9606	rogid:U1jEo7ZPG53cA/BcJs/BMGo/vWE9606	intact-crc:EC4FEA4F3704AECC|rigid:G937Pzr+FTvLKzQuJkstSTpSFlY	false	phosphorylated residue:?-?|sufficient binding region:349-556	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41240	uniprotkb:O15530	intact:EBI-1380630|uniprotkb:Q2M3N2|uniprotkb:Q6FGZ6|ensembl:ENSP00000220003|ensembl:ENSP00000414764|ensembl:ENSP00000454906	intact:EBI-717097|uniprotkb:Q8IV52|uniprotkb:Q9BRD5|uniprotkb:Q6FI20|uniprotkb:H0Y4Z0|uniprotkb:Q59EH6|intact:EBI-28968232|ensembl:ENSP00000344220	psi-mi:csk_human(display_long)|uniprotkb:CSK(gene name)|psi-mi:CSK(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase CYL(gene name synonym)	psi-mi:pdpk1_human(display_long)|uniprotkb:PDPK1(gene name)|psi-mi:PDPK1(display_short)|uniprotkb:PDK1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692630|imex:IM-22632-62	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001120662.1|refseq:NP_004374.1|refseq:XP_005254222.1|refseq:XP_016877414.1|ensembl:ENSG00000103653(gene)|ensembl:ENST00000220003(transcript)|ensembl:ENST00000439220(transcript)|ensembl:ENST00000567571(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|mint:P41240|rcsb pdb:1BYG|rcsb pdb:1CSK|rcsb pdb:3D7T|rcsb pdb:3D7U|rcsb pdb:3EAC|rcsb pdb:3EAZ|reactome:R-HSA-180292|reactome:R-HSA-202427|reactome:R-HSA-354192|reactome:R-HSA-389948|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9013407|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9706369|refseq:NM_001127190.1(identity)|entrezgene/locuslink:1445(identity)	refseq:NP_002604.1|refseq:NP_112558.2|ensembl:ENST00000268673|ensembl:ENSP00000268673|ensembl:ENSP00000344220|ensembl:ENST00000441549|ensembl:ENSP00000395357|refseq:NP_001248745.1|ensembl:ENSG00000140992(gene)|ensembl:ENST00000342085(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|rcsb pdb:1H1W|rcsb pdb:1OKY|rcsb pdb:1OKZ|rcsb pdb:1UU3|rcsb pdb:1UU7|rcsb pdb:1UU8|rcsb pdb:1UU9|rcsb pdb:1UVR|rcsb pdb:1W1G|rcsb pdb:1W1H|rcsb pdb:1Z5M|rcsb pdb:2BIY|rcsb pdb:2PE0|rcsb pdb:2PE1|rcsb pdb:2PE2|rcsb pdb:2R7B|rcsb pdb:2VKI|rcsb pdb:2XCH|rcsb pdb:2XCK|rcsb pdb:3H9O|rcsb pdb:3HRC|rcsb pdb:3HRF|rcsb pdb:3ION|rcsb pdb:3IOP|rcsb pdb:3NAX|rcsb pdb:3NAY|rcsb pdb:3NUN|rcsb pdb:3NUS|rcsb pdb:3NUU|rcsb pdb:3NUY|rcsb pdb:3ORX|rcsb pdb:3ORZ|rcsb pdb:3OTU|rcsb pdb:1W1D|rcsb pdb:3PWY|rcsb pdb:3QC4|rcsb pdb:3QCQ|rcsb pdb:3QCS|rcsb pdb:3QCX|rcsb pdb:3QCY|rcsb pdb:3QD0|rcsb pdb:3QD3|rcsb pdb:3QD4|rcsb pdb:3RCJ|rcsb pdb:3RWP|rcsb pdb:3RWQ|rcsb pdb:3SC1|rcsb pdb:4A06|rcsb pdb:4A07|rcsb pdb:4AW0|rcsb pdb:4AW1|rcsb pdb:4CT1|rcsb pdb:4CT2|rcsb pdb:4RQK|rcsb pdb:4RQV|rcsb pdb:4RRV|rcsb pdb:4XX9|rcsb pdb:5ACK|rcsb pdb:5HKM|rcsb pdb:5HNG|rcsb pdb:5HO7|rcsb pdb:5HO8|rcsb pdb:5LVL|rcsb pdb:5LVM|rcsb pdb:5LVN|rcsb pdb:5LVO|rcsb pdb:5LVP|rcsb pdb:5MRD|rcsb pdb:6WJQ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-165158|reactome:R-HSA-202424|reactome:R-HSA-2730905|reactome:R-HSA-2871837|reactome:R-HSA-354192|reactome:R-HSA-389357|reactome:R-HSA-392451|reactome:R-HSA-444257|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5625740|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-9634635|dip:DIP-38372N|entrezgene/locuslink:5170(identity)|refseq:NM_031268.5(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:9n6rgUUGjJ+e0fMPrB4A7JGyZqE9606	rogid:1Uf7b8GptL7XBfEZm43zB3ho6ZQ9606	intact-crc:D052422D85263645|rigid:wkU7z4mVATH3uQntxT4s2nL7aHo	false	phosphorylated residue:?-?	phosphorylated residue:?-?|sufficient binding region:408-556	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:O14669	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-9824765|uniprotkb:Q6IBF8|ensembl:ENSP00000246794	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:tmg2_human(display_long)|uniprotkb:PRRG2(gene name)|psi-mi:PRRG2(display_short)|uniprotkb:PRGP2(gene name synonym)|uniprotkb:TMG2(gene name synonym)|uniprotkb:Proline-rich gamma-carboxyglutamic acid protein 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692647|imex:IM-22632-63	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_000942.1|refseq:XP_006723349.1|ensembl:ENSP00000246794|dip:DIP-60947N|ensembl:ENSG00000126460(gene)|ensembl:ENST00000246794(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR035972|entrezgene/locuslink:5639(identity)|refseq:NM_000951.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FES (P07332), JAK2 (O60674)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:wkBqF06lHxIu/lz5GFK0tj9bPtU9606	intact-crc:8EF0B26E3A8A9337|rigid:rCwMhwjppM8rtdIAordjX9+oOrw	false	phosphorylated residue:?-?	phosphorylated residue:?-?|sufficient binding region:29-202	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763-2	uniprotkb:O00459	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692681|imex:IM-22632-65	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409|entrezgene/locuslink:5296(identity)|refseq:NM_005027.3(identity)	-	isoform-comment:Contains a phosphotyrosine at position 704.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606	intact-crc:B27072E617D5DF18|rigid:YjsSOIwDo4Hj7tFZ+8eBcDrR0oY	false	phosphorylated residue:?-?	phosphorylated residue:?-?|sufficient binding region:476-728	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00459	uniprotkb:P46108-2	intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692664|imex:IM-22632-64	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409|entrezgene/locuslink:5296(identity)|refseq:NM_005027.3(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:C4169752BB5A4422|rigid:VDV+yTCMN0vfoJqUyLy6JI8GGCk	false	sufficient binding region:476-728|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A6NJ69	uniprotkb:Q13387	intact:EBI-10692698|ensembl:ENSP00000327344	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:igip_human(display_long)|uniprotkb:IGIP(gene name)|psi-mi:IGIP(display_short)|uniprotkb:C5orf53(gene name synonym)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692702|imex:IM-22632-66	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001007190.1|ensembl:ENSG00000182700(gene)|ensembl:ENST00000333305(transcript)|go:"GO:0005576"(extracellular region)|interpro:IPR038815|refseq:NM_001007189.1(identity)|entrezgene/locuslink:492311(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:YMdw1Ve8L02Twy6Snv58/pCbOZ89606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:34DF55F34252EA08|rigid:mAOa93YRsqU2y1G7FbqQSyz0Yec	false	sufficient binding region:7-53|phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A1A4S6	uniprotkb:P78314	intact:EBI-1390944|uniprotkb:Q2VPC4|uniprotkb:Q2VPC5|uniprotkb:Q96EV3|uniprotkb:Q96S75|uniprotkb:A1L0S5|ensembl:ENSP00000336923	intact:EBI-727062|uniprotkb:O00500|uniprotkb:O15373|uniprotkb:P78315|uniprotkb:A6NNC2|uniprotkb:B2R5R6|uniprotkb:B4DT04|uniprotkb:D3DVR0|intact:EBI-28985856|ensembl:ENSP00000348685|ensembl:ENSP00000422168|uniprotkb:D6R919	psi-mi:rhg10_human(display_long)|uniprotkb:ARHGAP10(gene name)|psi-mi:ARHGAP10(display_short)|uniprotkb:GRAF2(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 10(gene name synonym)|uniprotkb:GTPase regulator associated with focal adhesion kinase 2(gene name synonym)|uniprotkb:Graf-related protein 2(gene name synonym)	psi-mi:3bp2_human(display_long)|uniprotkb:SH3BP2(gene name)|psi-mi:SH3BP2(display_short)|uniprotkb:3BP2(gene name synonym)|uniprotkb:RES4-23(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692719|imex:IM-22632-67	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078881.3|ensembl:ENSG00000071205(gene)|ensembl:ENST00000336498(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|interpro:IPR035485|interpro:IPR035486|interpro:IPR036028|rcsb pdb:2MIO|reactome:R-HSA-211728|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|refseq:XM_005263216.2(identity)|entrezgene/locuslink:79658(identity)	refseq:NP_001116153.1|refseq:NP_001139327.1|refseq:NP_001139328.1|refseq:NP_003014.3|ensembl:ENSP00000348685|ensembl:ENST00000435136|ensembl:ENSP00000403231|ensembl:ENSP00000422168|ensembl:ENST00000511747|ensembl:ENSP00000424846|ensembl:ENST00000513020|ensembl:ENSP00000424072|ensembl:ENST00000515737|ensembl:ENSP00000422605|ensembl:ENSG00000087266(gene)|ensembl:ENST00000356331(transcript)|ensembl:ENST00000503393(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035847|interpro:IPR035848|interpro:IPR036860|mint:P78314|rcsb pdb:2CR4|rcsb pdb:3TWR|entrezgene/locuslink:6452(identity)|refseq:NM_001122681.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:gbHj2b+qPHC9tKs3Y3eRicrt8mk9606	rogid:W+/geQfSvLlQA6UvDPYN4zQCzh89606	intact-crc:6C0FAE34CBF0D46D|rigid:6M7eC07h8InIpcSbnfd66/ciGbg	false	phosphorylated residue:?-?|sufficient binding region:572-786	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q9Y5E4	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-1045222|uniprotkb:Q9UFU9|uniprotkb:Q549F4|ensembl:ENSP00000231134	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:pcdb5_human(display_long)|uniprotkb:PCDHB5(gene name)|psi-mi:PCDHB5(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692736|imex:IM-22632-68	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	ensembl:ENSG00000113209(gene)|ensembl:ENST00000231134(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0045202"(synapse)|interpro:IPR002126(Cadherin)|interpro:IPR013164(Cadherin, N-terminal)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR030730|interpro:IPR032455|refseq:NP_056484.2|refseq:NM_015669.3(identity)|entrezgene/locuslink:26167(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), SYK (P43405), YES1 (P07947)."|comment:"The interaction failed to show if kinase-dead versions of ABL2 (P42684) or FYN (P06241) were used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:JHnksp8PK/4ubg/jnTZBT/uiLlk9606	intact-crc:353876E9A3C56102|rigid:wBDgV3oNiGoB1Z8n+18JNIenEks	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q9Y5E4	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-1045222|uniprotkb:Q9UFU9|uniprotkb:Q549F4|ensembl:ENSP00000231134	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:pcdb5_human(display_long)|uniprotkb:PCDHB5(gene name)|psi-mi:PCDHB5(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692752|imex:IM-22632-69	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	ensembl:ENSG00000113209(gene)|ensembl:ENST00000231134(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0045202"(synapse)|interpro:IPR002126(Cadherin)|interpro:IPR013164(Cadherin, N-terminal)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR030730|interpro:IPR032455|refseq:NP_056484.2|refseq:NM_015669.3(identity)|entrezgene/locuslink:26167(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FYN (P06241), JAK2 (O60674), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:JHnksp8PK/4ubg/jnTZBT/uiLlk9606	intact-crc:BC5DB20E28C1EA5E|rigid:CUSKG25kjdzLy34zqVo1QfI1gao	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:Q9Y575	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-2875625|ensembl:ENSP00000263634|ensembl:ENSP00000385085|uniprotkb:Q53TN8|uniprotkb:Q53TN0|uniprotkb:B3KPA3|uniprotkb:Q9NVZ2|uniprotkb:D6W5B4|uniprotkb:D6W5B5|uniprotkb:G8JLA9|uniprotkb:Q2TAI4	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:asb3_human(display_long)|uniprotkb:ASB3(gene name)|psi-mi:ASB3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692767|imex:IM-22632-70	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	go:"GO:0030315"(T-tubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0055117"(regulation of cardiac muscle contraction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036036|interpro:IPR036770|interpro:IPR037329|mint:Q9Y575|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000115239(gene)|ensembl:ENST00000263634(transcript)|ensembl:ENST00000406625(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|refseq:NP_001188894.1|refseq:NP_057199.1|refseq:NP_665862.1|refseq:NP_001157637.1|refseq:NM_016115.4(identity)|entrezgene/locuslink:51130(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:gIMKRtUzf90UdaMhaSwEmesN+KE9606	intact-crc:1E92D5E738539AF9|rigid:ByIH+zvsNIh3dHDQU9Mo6PRF7kw	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q9Y3I0	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-2107208|uniprotkb:Q6IAI0|uniprotkb:Q9BWL4|uniprotkb:Q9NTH1|uniprotkb:Q9P037|uniprotkb:Q9P0J3|uniprotkb:B2R6A8|intact:EBI-4399544|ensembl:ENSP00000216038	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:rtcb_human(display_long)|uniprotkb:3'-phosphate/5'-hydroxy nucleic acid ligase(gene name synonym)|uniprotkb:C22orf28(gene name synonym)|uniprotkb:HSPC117(orf name)|uniprotkb:RTCB(gene name)|psi-mi:RTCB(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692816|imex:IM-22632-73	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_055121.1|dip:DIP-46750N|ensembl:ENSG00000100220(gene)|ensembl:ENST00000216038(transcript)|go:"GO:0000971"(tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate)|go:"GO:0003723"(RNA binding)|go:"GO:0003972"("RNA ligase (ATP) activity")|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0017166"(vinculin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0072669"(tRNA-splicing ligase complex)|interpro:IPR001233(Protein of unknown function UPF0027)|interpro:IPR027513|interpro:IPR036025|mint:Q9Y3I0|reactome:R-HSA-6784531|entrezgene/locuslink:51493(identity)|refseq:NM_014306.4(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:URuCEq/DIn6DgR3jOb5fwnpDVXE9606	intact-crc:AB4C610F2EAE47D9|rigid:MObgY5jFXBCJWVIudWEen0u6MmA	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y4J8-9	uniprotkb:P40763-2	intact:EBI-10692782|ensembl:ENSP00000451516|ensembl:ENSP00000506928|ensembl:ENSP00000508348	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:q9y4j8-9(display_long)|uniprotkb:DTNA(gene name)|psi-mi:DTNA(display_short)|uniprotkb:Alpha-dystrobrevin(gene name synonym)|uniprotkb:DRP3(gene name synonym)|uniprotkb:Dystrophin-related protein 3(gene name synonym)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692786|imex:IM-22632-71	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134769(gene)|ensembl:ENST00000554864(transcript)|ensembl:ENST00000684610(transcript)|ensembl:ENST00000684734(transcript)|intact:EBI-949471(isoform-parent)|refseq:NM_001128175.1(identity)|entrezgene/locuslink:1837(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	-	isoform-comment:Contains a phosphotyrosine at position 704.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:TACvlVb+y+/F26d1ZiArVJcEFFI9606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:D53E8123365D2957|rigid:xsdID5nSqrqzPlG9aV8zCTAzCAI	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:Q9Y4J8-9	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-10692782|ensembl:ENSP00000451516|ensembl:ENSP00000506928|ensembl:ENSP00000508348	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:q9y4j8-9(display_long)|uniprotkb:DTNA(gene name)|psi-mi:DTNA(display_short)|uniprotkb:Alpha-dystrobrevin(gene name synonym)|uniprotkb:DRP3(gene name synonym)|uniprotkb:Dystrophin-related protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692801|imex:IM-22632-72	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	ensembl:ENSG00000134769(gene)|ensembl:ENST00000554864(transcript)|ensembl:ENST00000684610(transcript)|ensembl:ENST00000684734(transcript)|intact:EBI-949471(isoform-parent)|refseq:NM_001128175.1(identity)|entrezgene/locuslink:1837(identity)	-	crc64:6C00632211C8012D	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:TACvlVb+y+/F26d1ZiArVJcEFFI9606	intact-crc:4F2015FD2DFEAE99|rigid:l+0WO9uyJwHEWCvC14XwFEfrhXw	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:Q9Y2X9	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-396200|uniprotkb:Q9NY92|uniprotkb:A6NF48|uniprotkb:B3KMX2|uniprotkb:Q5RKW5|intact:EBI-11018373|ensembl:ENSP00000294740|ensembl:ENSP00000356322	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:zn281_human(display_long)|uniprotkb:ZNF281(gene name)|psi-mi:ZNF281(display_short)|uniprotkb:GZP1(gene name synonym)|uniprotkb:ZBP99(gene name synonym)|uniprotkb:Zinc finger DNA-binding protein 99(gene name synonym)|uniprotkb:Transcription factor ZBP-99(gene name synonym)|uniprotkb:GC-box-binding zinc finger protein 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692846|imex:IM-22632-75	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_036614.1|refseq:NP_001268222.1|refseq:NP_001268223.1|refseq:XP_016856376.1|refseq:XP_016856377.1|ensembl:ENSG00000162702(gene)|ensembl:ENST00000294740(transcript)|ensembl:ENST00000367353(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9Y2X9|entrezgene/locuslink:23528(identity)|refseq:NM_012482.4(identity)	-	crc64:6C00632211C8012D	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:bjmz9ne6FkC0kbJUv13u8IoDYHM9606	intact-crc:B249B3CD84B288ED|rigid:E+9OytdhQ8VjK+tM1xm/HwBLzEo	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q9Y2X9	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-396200|uniprotkb:Q9NY92|uniprotkb:A6NF48|uniprotkb:B3KMX2|uniprotkb:Q5RKW5|intact:EBI-11018373|ensembl:ENSP00000294740|ensembl:ENSP00000356322	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:zn281_human(display_long)|uniprotkb:ZNF281(gene name)|psi-mi:ZNF281(display_short)|uniprotkb:GZP1(gene name synonym)|uniprotkb:ZBP99(gene name synonym)|uniprotkb:Zinc finger DNA-binding protein 99(gene name synonym)|uniprotkb:Transcription factor ZBP-99(gene name synonym)|uniprotkb:GC-box-binding zinc finger protein 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692861|imex:IM-22632-76	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_036614.1|refseq:NP_001268222.1|refseq:NP_001268223.1|refseq:XP_016856376.1|refseq:XP_016856377.1|ensembl:ENSG00000162702(gene)|ensembl:ENST00000294740(transcript)|ensembl:ENST00000367353(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9Y2X9|entrezgene/locuslink:23528(identity)|refseq:NM_012482.4(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:bjmz9ne6FkC0kbJUv13u8IoDYHM9606	intact-crc:F828F07490F63425|rigid:ITUn8Irqdixigyt+DueEZcAK0Yw	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:Q9Y3I0	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-2107208|uniprotkb:Q6IAI0|uniprotkb:Q9BWL4|uniprotkb:Q9NTH1|uniprotkb:Q9P037|uniprotkb:Q9P0J3|uniprotkb:B2R6A8|intact:EBI-4399544|ensembl:ENSP00000216038	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:rtcb_human(display_long)|uniprotkb:3'-phosphate/5'-hydroxy nucleic acid ligase(gene name synonym)|uniprotkb:C22orf28(gene name synonym)|uniprotkb:HSPC117(orf name)|uniprotkb:RTCB(gene name)|psi-mi:RTCB(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692831|imex:IM-22632-74	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	refseq:NP_055121.1|dip:DIP-46750N|ensembl:ENSG00000100220(gene)|ensembl:ENST00000216038(transcript)|go:"GO:0000971"(tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate)|go:"GO:0003723"(RNA binding)|go:"GO:0003972"("RNA ligase (ATP) activity")|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0017166"(vinculin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0072669"(tRNA-splicing ligase complex)|interpro:IPR001233(Protein of unknown function UPF0027)|interpro:IPR027513|interpro:IPR036025|mint:Q9Y3I0|reactome:R-HSA-6784531|entrezgene/locuslink:51493(identity)|refseq:NM_014306.4(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:URuCEq/DIn6DgR3jOb5fwnpDVXE9606	intact-crc:ECE7B79472232147|rigid:cX6dThTWLBA6ZO4DmhaT9CvB0Dc	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEU8	uniprotkb:Q9UPY8	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	intact:EBI-726739|uniprotkb:O00265|uniprotkb:Q6FI15|uniprotkb:Q9BZP7|uniprotkb:Q9BZP8|uniprotkb:B7WPK5|uniprotkb:Q6FHB0|ensembl:ENSP00000233121	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:mare3_human(display_long)|uniprotkb:End-binding protein 3(gene name synonym)|uniprotkb:EB1 protein family member 3(gene name synonym)|uniprotkb:RP3(gene name synonym)|uniprotkb:MAPRE3(gene name)|psi-mi:MAPRE3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692876|imex:IM-22632-77	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	refseq:NP_036458.2|refseq:XP_016859086.1|refseq:NP_001289979.1|refseq:XP_006712030.1|refseq:XP_011531002.1|dip:DIP-56069N|ensembl:ENSG00000084764(gene)|ensembl:ENST00000233121(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042802"(identical protein binding)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:1903033"(positive regulation of microtubule plus-end binding)|go:"GO:1904825"(protein localization to microtubule plus-end)|go:"GO:1905721"(mitotic spindle astral microtubule end)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR004953(EB1, C-terminal)|interpro:IPR027328|interpro:IPR027738|interpro:IPR036133|interpro:IPR036872|mint:Q9UPY8|rcsb pdb:1WYO|rcsb pdb:3CO1|rcsb pdb:3JAK|rcsb pdb:3JAL|rcsb pdb:3JAR|rcsb pdb:3TQ7|refseq:NM_012326.2(identity)|entrezgene/locuslink:22924(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FRK (P42685), JAK2 (O60674), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	rogid:LHuufxyNrygS3iFW5mmg13R43NE9606	intact-crc:E95DC4E9FAEB9106|rigid:XL9MNPPuKrxZcLoNx7evVqk8Aw0	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UIL1-3	uniprotkb:Q9P104-2	intact:EBI-10692913	intact:EBI-10692909|ensembl:ENSP00000379270	psi-mi:q9uil1-3(display_long)|uniprotkb:SCOC(gene name)|psi-mi:SCOC(display_short)|uniprotkb:SCOCO(gene name synonym)|uniprotkb:HRIHFB2072(orf name)	psi-mi:q9p104-2(display_long)|uniprotkb:DOK5(gene name)|psi-mi:DOK5(display_short)|uniprotkb:C20orf180(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 5(gene name synonym)|uniprotkb:Insulin receptor substrate 6(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692906|imex:IM-22632-79	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2686537(isoform-parent)|uniprotkb:Q9UIL1-3(isoform-parent)|entrezgene/locuslink:60592(identity)|refseq:NM_001153635.1(identity)	ensembl:ENSG00000101134(gene)|ensembl:ENST00000395939(transcript)|intact:EBI-739600(isoform-parent)|uniprotkb:Q9P104-2(isoform-parent)|refseq:NM_177959.2(identity)|entrezgene/locuslink:55816(identity)	-	isoform-comment:No experimental confirmation available.	isoform-comment:No experimental confirmation available.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FES (P07332), PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:jS3ZpyUvY0MRgdySRnveYgX0raU9606	rogid:8p18JpE/uszPiQyb4FtcEu5QiOc9606	intact-crc:9BE6248D960569E6|rigid:2FhzqFejY+mluU82Feq1fTRH5rs	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9ULV8	uniprotkb:P46108-2	intact:EBI-2341018|uniprotkb:Q9Y5Z3|uniprotkb:Q8N1E5|uniprotkb:Q9Y5Z2|intact:EBI-28975910|ensembl:ENSP00000494162	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:cblc_human(display_long)|uniprotkb:CBLC(gene name)|psi-mi:CBLC(display_short)|uniprotkb:CBL3(gene name synonym)|uniprotkb:RNF57(gene name synonym)|uniprotkb:SH3-binding protein CBL-C(gene name synonym)|uniprotkb:SH3-binding protein CBL-3(gene name synonym)|uniprotkb:RING finger protein 57(gene name synonym)|uniprotkb:Signal transduction protein CBL-C(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-C(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692891|imex:IM-22632-78	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000341505|ensembl:ENSP00000340250|ensembl:ENSP00000494162|refseq:NP_001124324.1|refseq:NP_036248.3|ensembl:ENSG00000142273(gene)|ensembl:ENST00000647358(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|rcsb pdb:3OP0|rcsb pdb:3VRN|rcsb pdb:3VRO|rcsb pdb:3VRP|rcsb pdb:3VRQ|rcsb pdb:3VRR|refseq:NM_012116.3(identity)|entrezgene/locuslink:23624(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:syzTzR6RGJzLv2EpDirSrli4ghs9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:97A5C55013A4A7C2|rigid:kwx4I8lb7QtYjAoPwhGN+FWmRRg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UIH9	uniprotkb:Q9UKG1	intact:EBI-2796400|ensembl:ENSP00000296233	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:klf15_human(display_long)|uniprotkb:KKLF(gene name synonym)|uniprotkb:Kidney-enriched krueppel-like factor(gene name synonym)|uniprotkb:KLF15(gene name)|psi-mi:KLF15(display_short)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692929|imex:IM-22632-80	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054798.1|refseq:XP_005247457.1|ensembl:ENSG00000163884(gene)|ensembl:ENST00000296233(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016607"(nuclear speck)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9UIH9|rcsb pdb:2ENT|reactome:R-HSA-1368108|entrezgene/locuslink:28999(identity)|refseq:NM_014079.3(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:vocV1ptKE68rlXylNPMj/4qjo689606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:39DC3E5328737CFD|rigid:PKw27QqRSHQEGeBOXXTxdFdOz0I	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q9UHJ3	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-747398|uniprotkb:Q96C73|uniprotkb:Q9Y4Q9|uniprotkb:Q402F7|ensembl:ENSP00000378235	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:smbt1_human(display_long)|uniprotkb:Renal ubiquitous protein 1(gene name synonym)|uniprotkb:SFMBT1(gene name)|psi-mi:SFMBT1(display_short)|uniprotkb:RU1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692944|imex:IM-22632-81	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	refseq:XP_006713266.1|refseq:XP_006713267.1|refseq:NP_057413.2|refseq:XP_011532126.1|refseq:XP_011532127.1|refseq:XP_005265278.1|ensembl:ENSG00000163935(gene)|ensembl:ENST00000394752(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048635"(negative regulation of muscle organ development)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR004092(Mbt repeat)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR021987|interpro:IPR037604|interpro:IPR038348|mint:Q9UHJ3|refseq:NM_016329.3(identity)|entrezgene/locuslink:51460(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:vh/dDMpcLQEo57Wcjnggufh6HRk9606	intact-crc:0DD6E19421CA3287|rigid:Co74Mnmuxcvm2i1yp5rZc7voUiw	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UF11-4	uniprotkb:Q9NP31	intact:EBI-9089825|ensembl:ENSP00000227214|ensembl:ENSP00000442616	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:q9uf11-4(display_long)|uniprotkb:EVT1(gene name synonym)|uniprotkb:Evectin-1(gene name synonym)|uniprotkb:KPL1(gene name synonym)|uniprotkb:PH domain-containing protein in retina 1(gene name synonym)|uniprotkb:PHR1(gene name synonym)|uniprotkb:PHRET1(gene name synonym)|uniprotkb:Pleckstrin homology domain retinal protein 1(gene name synonym)|uniprotkb:PLEKHB1(gene name)|psi-mi:PLEKHB1(display_short)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692959|imex:IM-22632-82	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6447271(isoform-parent)|ensembl:ENSG00000021300(gene)|ensembl:ENST00000227214(transcript)|ensembl:ENST00000535129(transcript)|entrezgene/locuslink:58473(identity)|refseq:NM_001130035.1(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FRK (P42685), FYN (P06241), JAK2 (O60674), SYK (P43405)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:5RmF2rJLHJT3yM6ZP4+m7unTGNs9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:5D90C987D9B66996|rigid:OG0e/at7nc4V8Xy07NpI6744KlI	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBX0	uniprotkb:P40763	intact:EBI-8470369|intact:MINT-8417673|uniprotkb:Q99667|uniprotkb:Q52LC5|ensembl:ENSP00000295934|ensembl:ENSP00000498190	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:hesx1_human(display_long)|uniprotkb:HESX1(gene name)|psi-mi:HESX1(display_short)|uniprotkb:HANF(gene name synonym)|uniprotkb:Homeobox protein ANF(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692989|imex:IM-22632-84	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011532506.1|refseq:XP_011532507.1|refseq:NP_003856.1|refseq:XP_005265583.1|refseq:XP_006713442.1|refseq:XP_016862910.1|ensembl:ENSG00000163666(gene)|ensembl:ENST00000295934(transcript)|ensembl:ENST00000647958(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008406"(gonad development)|go:"GO:0010467"(gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043584"(nose development)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR043402|mint:Q9UBX0|rcsb pdb:2K40|refseq:NM_003865.2(identity)|entrezgene/locuslink:8820(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	comment:mint|comment:homomint	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ZnU6Y5Ypmp2rPpmN9ONoyIJgGhg9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:C15D95AFA54142B4|rigid:u2I/72bwiU28JxbCpcp7/K5iZEU	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBX0	uniprotkb:P40763-2	intact:EBI-8470369|intact:MINT-8417673|uniprotkb:Q99667|uniprotkb:Q52LC5|ensembl:ENSP00000295934|ensembl:ENSP00000498190	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:hesx1_human(display_long)|uniprotkb:HESX1(gene name)|psi-mi:HESX1(display_short)|uniprotkb:HANF(gene name synonym)|uniprotkb:Homeobox protein ANF(gene name synonym)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10692974|imex:IM-22632-83	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011532506.1|refseq:XP_011532507.1|refseq:NP_003856.1|refseq:XP_005265583.1|refseq:XP_006713442.1|refseq:XP_016862910.1|ensembl:ENSG00000163666(gene)|ensembl:ENST00000295934(transcript)|ensembl:ENST00000647958(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008406"(gonad development)|go:"GO:0010467"(gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043584"(nose development)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR043402|mint:Q9UBX0|rcsb pdb:2K40|refseq:NM_003865.2(identity)|entrezgene/locuslink:8820(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	comment:mint|comment:homomint	isoform-comment:Contains a phosphotyrosine at position 704.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ZnU6Y5Ypmp2rPpmN9ONoyIJgGhg9606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:CE26CE32EBCE0C15|rigid:Zkw7BcQ68lFYZx5pDU2v+YMJEh0	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P289-3	uniprotkb:Q14449	intact:EBI-10693004|ensembl:ENSP00000419702	intact:EBI-2680889|uniprotkb:B7Z7F9|uniprotkb:Q7Z6I1|ensembl:ENSP00000263915	psi-mi:q9p289-3(display_long)|uniprotkb:STK26(gene name)|psi-mi:STK26(display_short)|uniprotkb:MASK(gene name synonym)|uniprotkb:MST3 and SOK1-related kinase(gene name synonym)|uniprotkb:MST4(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase MASK(gene name synonym)|uniprotkb:MST4a(isoform synonym)	psi-mi:grb14_human(display_long)|uniprotkb:GRB14 adapter protein(gene name synonym)|uniprotkb:GRB14(gene name)|psi-mi:GRB14(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693008|imex:IM-22632-85	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134602(gene)|ensembl:ENST00000496850(transcript)|intact:EBI-618239(isoform-parent)|entrezgene/locuslink:51765(identity)|refseq:NM_001042452.1(identity)	refseq:NP_004481.2|refseq:NP_001290351.1|ensembl:ENSG00000115290(gene)|ensembl:ENST00000263915(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035034|interpro:IPR035035|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q14449|rcsb pdb:2AUG|rcsb pdb:2AUH|rcsb pdb:4K81|reactome:R-HSA-210993|go:"GO:0008286"(insulin receptor signaling pathway)|dip:DIP-42605N|entrezgene/locuslink:2888(identity)|refseq:NM_004490.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:YBiuuqETpdEu0sZrYy4YI8bJsU49606	rogid:b3Xtmki3fCyyoRra/IQWuGIQDCU9606	intact-crc:8E7CDBB5CA7331DA|rigid:UUdMUCf5qTJKOSCWQCAKR9z/RC4	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NSI6-4	uniprotkb:P40763-2	intact:EBI-10693038|ensembl:ENSP00000342106	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:q9nsi6-4(display_long)|uniprotkb:BRWD1(gene name)|psi-mi:BRWD1(display_short)|uniprotkb:C21orf107(gene name synonym)|uniprotkb:WD repeat-containing protein 9(gene name synonym)|uniprotkb:WDR9(gene name synonym)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693042|imex:IM-22632-87	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1996384(isoform-parent)|uniprotkb:Q9NSI6-4(isoform-parent)|ensembl:ENSG00000185658(gene)|ensembl:ENST00000341322(transcript)|entrezgene/locuslink:54014(identity)|refseq:NM_001007246.2(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	-	isoform-comment:Contains a phosphotyrosine at position 704.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:vfir0aZ5Af/ptv8i+BAAGpNn5wg9606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:D0C68964F414E91F|rigid:ScvXbPpUiw+rR96OssJSTiKfQhQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NVE4	uniprotkb:P40763	intact:EBI-749261|uniprotkb:Q8NE76|ensembl:ENSP00000328487	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:ccd87_human(display_long)|uniprotkb:CCDC87(gene name)|psi-mi:CCDC87(display_short)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693023|imex:IM-22632-86	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060689.2|ensembl:ENSP00000328487|ensembl:ENSG00000182791(gene)|ensembl:ENST00000333861(transcript)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0030154"(cell differentiation)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:2000344"(positive regulation of acrosome reaction)|interpro:IPR037383|refseq:NM_018219.2(identity)|entrezgene/locuslink:55231(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SfXyZIfbueunH5g/6biF1Pabyrc9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:D4CF01F8FDDE4F5A|rigid:5moLGP1cgmG1dgUAf/LfOWYuQ6E	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:Q9NSI6-4	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-10693038|ensembl:ENSP00000342106	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:q9nsi6-4(display_long)|uniprotkb:BRWD1(gene name)|psi-mi:BRWD1(display_short)|uniprotkb:C21orf107(gene name synonym)|uniprotkb:WD repeat-containing protein 9(gene name synonym)|uniprotkb:WDR9(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693057|imex:IM-22632-88	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	intact:EBI-1996384(isoform-parent)|uniprotkb:Q9NSI6-4(isoform-parent)|ensembl:ENSG00000185658(gene)|ensembl:ENST00000341322(transcript)|entrezgene/locuslink:54014(identity)|refseq:NM_001007246.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:vfir0aZ5Af/ptv8i+BAAGpNn5wg9606	intact-crc:A585EEF5D177FF1E|rigid:WHNUg8Hp8MdskMRt6mH9RIRqiP4	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NR55	uniprotkb:Q9UKG1	intact:EBI-10312707|ensembl:ENSP00000243440	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:batf3_human(display_long)|uniprotkb:BATF3(gene name)|psi-mi:BATF3(display_short)|uniprotkb:21 kDa small nuclear factor isolated from T-cells(gene name synonym)|uniprotkb:Jun dimerization protein p21SNFT(gene name synonym)|uniprotkb:SNFT(gene name synonym)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693072|imex:IM-22632-89	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061134.1|ensembl:ENSG00000123685(gene)|ensembl:ENST00000243440(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029818|entrezgene/locuslink:55509(identity)|refseq:NM_018664.2(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:hAyP6YHxONSUFMehlesRDi+E0z49606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:9803B0DCD6704191|rigid:++3gYcSFd+4WtPDXwhGVp/QbHmo	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q9NPC6	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-746712|uniprotkb:O43415|uniprotkb:Q9HB92|ensembl:ENSP00000306997	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:myoz2_human(display_long)|uniprotkb:Calsarcin-1(gene name synonym)|uniprotkb:FATZ-related protein 2(gene name synonym)|uniprotkb:MYOZ2(gene name)|psi-mi:MYOZ2(display_short)|uniprotkb:C4orf5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693087|imex:IM-22632-90	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_057683.1|ensembl:ENSG00000172399(gene)|ensembl:ENST00000307128(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003779"(actin binding)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031433"(telethonin binding)|go:"GO:0043503"(skeletal muscle fiber adaptation)|go:"GO:0045214"(sarcomere organization)|go:"GO:0051373"(FATZ binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR008438(Calcineurin-binding)|refseq:NM_016599.4(identity)|entrezgene/locuslink:51778(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:Y2B5tDM2oGscI8xiTwB69hFEhL89606	intact-crc:9F603385E0A43726|rigid:2s+hGheVFSXSVatqE5DYzqfNZcM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NPB6-2	uniprotkb:Q92569	intact:EBI-10693102|ensembl:ENSP00000392388	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:q9npb6-2(display_long)|uniprotkb:PARD6A(gene name)|psi-mi:PARD6A(display_short)|uniprotkb:PAR6A(gene name synonym)|uniprotkb:PAR6C(gene name synonym)|uniprotkb:Tax interaction protein 40(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693122|imex:IM-22632-92	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-81876(isoform-parent)|ensembl:ENSG00000102981(gene)|ensembl:ENST00000458121(transcript)|uniprotkb:Q9NPB6-2(isoform-parent)|refseq:NM_001037281.1(identity)|entrezgene/locuslink:50855(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:hLX1kt+/BGPnr4HvpWndVysxrTU9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:00F1303A5F3B2495|rigid:K1GhwAs/nCfrSXIkvVeP3DngJUo	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NPB6-2	uniprotkb:P62993	intact:EBI-10693102|ensembl:ENSP00000392388	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:q9npb6-2(display_long)|uniprotkb:PARD6A(gene name)|psi-mi:PARD6A(display_short)|uniprotkb:PAR6A(gene name synonym)|uniprotkb:PAR6C(gene name synonym)|uniprotkb:Tax interaction protein 40(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693106|imex:IM-22632-91	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-81876(isoform-parent)|ensembl:ENSG00000102981(gene)|ensembl:ENST00000458121(transcript)|uniprotkb:Q9NPB6-2(isoform-parent)|refseq:NM_001037281.1(identity)|entrezgene/locuslink:50855(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), SYK (P43405), YES1 (P07947)."|comment:"The interaction failed to show if kinase-dead versions of ABL2 (P42684) or FYN (P06241) were used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:hLX1kt+/BGPnr4HvpWndVysxrTU9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:D495844816F82F31|rigid:LuRVnZJWGHvsq8dtCFq7HwULj8g	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q9NP31	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693152|imex:IM-22632-94	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:CAD894A6B8FE9C38|rigid:M44s/PAj0o5eyb+1TqIeSXUm1YU	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP98	uniprotkb:P62993	intact:EBI-744402|ensembl:ENSP00000352272|uniprotkb:Q9H1I7	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:myoz1_human(display_long)|uniprotkb:Calsarcin-2(gene name synonym)|uniprotkb:Filamin-, actinin- and telethonin-binding protein(gene name synonym)|uniprotkb:Protein FATZ(gene name synonym)|uniprotkb:MYOZ1(gene name)|psi-mi:MYOZ1(display_short)|uniprotkb:MYOZ(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693137|imex:IM-22632-93	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177791(gene)|ensembl:ENST00000359322(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003779"(actin binding)|go:"GO:0004865"(protein serine/threonine phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030239"(myofibril assembly)|go:"GO:0031143"(pseudopodium)|go:"GO:0031433"(telethonin binding)|go:"GO:0042060"(wound healing)|go:"GO:0043417"(negative regulation of skeletal muscle tissue regeneration)|go:"GO:0043503"(skeletal muscle fiber adaptation)|go:"GO:0045214"(sarcomere organization)|go:"GO:0051373"(FATZ binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR008438(Calcineurin-binding)|mint:Q9NP98|rcsb pdb:7A8T|rcsb pdb:7A8U|refseq:NP_067068.1|rcsb pdb:7ANK|refseq:NM_021245.3(identity)|entrezgene/locuslink:58529(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:FRXTAudzeuW6TsUXL485GDV9ZX09606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:557A62053919B5ED|rigid:lnHmHNm9QDND5vjWwXmVUyA349s	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q9NP31	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693167|imex:IM-22632-95	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:7FB8254A8DB64562|rigid:cZ4wLCmnoAbpq3Gj29dHtEGHQnQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14543	uniprotkb:Q9NP31	intact:EBI-714146|uniprotkb:O14509|ensembl:ENSP00000330341	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:socs3_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 3(gene name synonym)|uniprotkb:SOCS3(gene name)|psi-mi:SOCS3(display_short)|uniprotkb:CIS3(gene name synonym)|uniprotkb:SSI3(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693182|imex:IM-22632-96	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O14543|reactome:R-HSA-1059683|reactome:R-HSA-2586552|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8849474|reactome:R-HSA-8939242|reactome:R-HSA-8951664|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|go:"GO:0050728"(negative regulation of inflammatory response)|ensembl:ENSG00000184557(gene)|ensembl:ENST00000330871(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|refseq:NP_003946.3|entrezgene/locuslink:9021(identity)|refseq:NM_003955.4(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8HnU9EL52BGdud2WFZwYsv5R22I9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:A0F2166CE6A70A77|rigid:JZXoO/O0u4W5qzJ2wzC0Mtxv8KM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763-2	uniprotkb:Q9NP31	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693197|imex:IM-22632-97	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	isoform-comment:Contains a phosphotyrosine at position 704.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:045F6E6E7C921977|rigid:gQL7oBFA+z4YtXj1NUJWcJRsr4A	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:Q9NP31	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693227|imex:IM-22632-99	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:5C1DBFAAD20C1BC1|rigid:jY22HffVts37wBZshubd31F8SJ0	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:Q9NP31	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693212|imex:IM-22632-98	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	crc64:6C00632211C8012D	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:E4811F48D2FA0468|rigid:n2XQnkZPjaygUtNNHAR1X6Mg7VM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96IW2	uniprotkb:Q9HC96	intact:EBI-4402781|uniprotkb:Q96NC2|ensembl:ENSP00000446058	intact:EBI-3915761|uniprotkb:Q8NCD4|uniprotkb:Q9HC90|uniprotkb:Q9HC95|uniprotkb:Q4ZFV1|uniprotkb:Q96JI2|uniprotkb:A8MVS7|uniprotkb:Q9HC94|uniprotkb:Q96IG4|uniprotkb:Q9HC89|uniprotkb:Q9HC92|uniprotkb:Q9HC91|uniprotkb:Q9HC93|ensembl:ENSP00000375844	psi-mi:shd_human(display_long)|uniprotkb:SHD(gene name)|psi-mi:SHD(display_short)	psi-mi:can10_human(display_long)|uniprotkb:CAPN10(gene name)|psi-mi:CAPN10(display_short)|uniprotkb:KIAA1845(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 10(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693242|imex:IM-22632-100	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064594.3|ensembl:ENSG00000105251(gene)|go:"GO:0001784"(phosphotyrosine residue binding)|interpro:IPR000980(SH2 motif)|interpro:IPR035039|interpro:IPR035046|interpro:IPR036860|ensembl:ENST00000543264(transcript)|entrezgene/locuslink:56961(identity)|refseq:NM_020209.3(identity)	refseq:NP_075571.1|refseq:NP_075573.2|ensembl:ENSG00000142330(gene)|ensembl:ENST00000391984(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006921"(cellular component disassembly involved in execution phase of apoptosis)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR028791|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|reactome:R-HSA-1474228|entrezgene/locuslink:11132(identity)|refseq:NM_023083.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:c2PsXxVdBB1dLj+Lu40XdgOb2yY9606	rogid:qXRiuthkIdLlLN+Fm5tPitkirMc9606	intact-crc:212159FD1561816D|rigid:UBgxiKSM5LF8kQxkNVSRGIlUfd8	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H7E9	uniprotkb:Q13387	intact:EBI-715389|uniprotkb:A6NGC0|uniprotkb:Q96BT8|ensembl:ENSP00000330361	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:ch033_human(display_long)|uniprotkb:C8orf33(gene name)|psi-mi:C8orf33(display_short)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693278|imex:IM-22632-102	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075568.1|ensembl:ENSG00000182307(gene)|ensembl:ENST00000331434(transcript)|interpro:IPR029274|mint:Q9H7E9|refseq:NM_023080.2(identity)|entrezgene/locuslink:65265(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FRK (P42685)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:R2UNBJ/dYewCXrmuO3E9apROd+Q9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:413B38917666F95D|rigid:EuHGROUDWN7FWLF0JH7Y0SuEbkE	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H7T9	uniprotkb:P62993	intact:EBI-10693257|uniprotkb:C9EI59|uniprotkb:Q53F70|ensembl:ENSP00000363416	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:aunip_human(display_long)|uniprotkb:AUNIP(gene name)|psi-mi:AUNIP(display_short)|uniprotkb:C1orf135(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693263|imex:IM-22632-101	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001274419.1|refseq:NP_076942.1|ensembl:ENSG00000127423(gene)|ensembl:ENST00000374298(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000922"(spindle pole)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0090734"(site of DNA damage)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR029286|entrezgene/locuslink:79000(identity)|refseq:NM_024037.2(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:z7isXKkndjeP4zxnq0kVAW+ZmRo9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:CB3A82496A76F66C|rigid:XGPbrBfaF95RtBoZE5bJbxTQLZk	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H706	uniprotkb:P46108-2	intact:EBI-3440103|uniprotkb:Q0VAG3|uniprotkb:Q9BSF5|uniprotkb:Q8ND03|uniprotkb:Q0VAG4|intact:EBI-28975682|ensembl:ENSP00000269209	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:gare1_human(display_long)|uniprotkb:GAREM1(gene name)|psi-mi:GAREM1(display_short)|uniprotkb:C18orf11(gene name synonym)|uniprotkb:FAM59A(gene name synonym)|uniprotkb:GAREM(gene name synonym)|uniprotkb:GRB2-associated and regulator of MAPK1(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693293|imex:IM-22632-103	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000269209|ensembl:ENST00000399218|ensembl:ENSP00000382165|refseq:NP_001229338.1|refseq:NP_073588.1|ensembl:ENSG00000141441(gene)|ensembl:ENST00000269209(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR025946|rcsb pdb:2DKZ|entrezgene/locuslink:64762(identity)|refseq:NM_001242409.1(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:QEmdhomnnbwOJjOYfPZptJdHqbA9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:2D290D538F6BFA39|rigid:NNrh7DgkEMl/fxsH1ZpHowU6Gv8	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q9H706	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-3440103|uniprotkb:Q0VAG3|uniprotkb:Q9BSF5|uniprotkb:Q8ND03|uniprotkb:Q0VAG4|intact:EBI-28975682|ensembl:ENSP00000269209	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:gare1_human(display_long)|uniprotkb:GAREM1(gene name)|psi-mi:GAREM1(display_short)|uniprotkb:C18orf11(gene name synonym)|uniprotkb:FAM59A(gene name synonym)|uniprotkb:GAREM(gene name synonym)|uniprotkb:GRB2-associated and regulator of MAPK1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693308|imex:IM-22632-104	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	ensembl:ENSP00000269209|ensembl:ENST00000399218|ensembl:ENSP00000382165|refseq:NP_001229338.1|refseq:NP_073588.1|ensembl:ENSG00000141441(gene)|ensembl:ENST00000269209(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR025946|rcsb pdb:2DKZ|entrezgene/locuslink:64762(identity)|refseq:NM_001242409.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:QEmdhomnnbwOJjOYfPZptJdHqbA9606	intact-crc:A46ED9E0F32E425A|rigid:hiTRaJyzha/h+ZzETOmC9WjPb48	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H4I2-2	uniprotkb:Q9NP31	intact:EBI-10693326|ensembl:ENSP00000443783	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:q9h4i2-2(display_long)|uniprotkb:ZHX3(gene name)|psi-mi:ZHX3(display_short)|uniprotkb:KIAA0395(gene name synonym)|uniprotkb:TIX1(gene name synonym)|uniprotkb:Triple homeobox protein 1(gene name synonym)|uniprotkb:Zinc finger and homeodomain protein 3(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693323|imex:IM-22632-105	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000174306(gene)|ensembl:ENST00000544979(transcript)|intact:EBI-948582(isoform-parent)|uniprotkb:Q9H4I2-2(isoform-parent)|refseq:XM_005260341.2(identity)|entrezgene/locuslink:23051(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	isoform-comment:No experimental confirmation available.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:l8isziiF3UQqrddT+mTWDc0ZBGk9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:57437AEB4A8129D3|rigid:Wd4F+qZBMffHDjLsLGt5MlTHXy0	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H3H1-2	uniprotkb:Q5VZ18	intact:EBI-10693345	intact:EBI-3956977|uniprotkb:Q8TEQ5|ensembl:ENSP00000307369	psi-mi:q9h3h1-2(display_long)|uniprotkb:tRNA isopentenyltransferase 1(gene name synonym)|uniprotkb:TRIT1(gene name)|psi-mi:TRIT1(display_short)|uniprotkb:IPT(gene name synonym)|uniprotkb:"Isopentenyl-diphosphate:tRNA isopentenyltransferase"(gene name synonym)|uniprotkb:MOD5(gene name synonym)|uniprotkb:hGRO1(gene name synonym)	psi-mi:she_human(display_long)|uniprotkb:SHE(gene name)|psi-mi:SHE(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693342|imex:IM-22632-106	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-720913(isoform-parent)|refseq:XM_006710706.1(identity)|entrezgene/locuslink:54802(identity)	refseq:XP_011507465.1|refseq:NP_001010846.1|ensembl:ENSG00000169291(gene)|ensembl:ENST00000304760(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|interpro:IPR000980(SH2 motif)|interpro:IPR035041|interpro:IPR035042|interpro:IPR036860|entrezgene/locuslink:126669(identity)|refseq:NM_001010846.2(identity)	-	isoform-comment:No experimental confirmation available.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:99w7Wm+fBfaBVAbobo5LmutMLgg9606	rogid:ZN2ORmTe7ETaKpdPvYPJP3yQKbI9606	intact-crc:71D3B4B36D7C27C7|rigid:Zre1SKSHQ8VA7Fx2GZFxrVdhBzg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BYZ2	uniprotkb:Q96JZ2	intact:EBI-1108377|uniprotkb:Q6DUY4|uniprotkb:Q96LI2|ensembl:ENSP00000302393	intact:EBI-3919324|intact:EBI-28973686|ensembl:ENSP00000482604|ensembl:ENSP00000483354|uniprotkb:B5ME72|uniprotkb:Q6ZNG7	psi-mi:ldh6b_human(display_long)|uniprotkb:LDHAL6B(gene name)|psi-mi:LDHAL6B(display_short)|uniprotkb:LDHAL6(gene name synonym)|uniprotkb:LDHL(gene name synonym)	psi-mi:hsh2d_human(display_long)|uniprotkb:HSH2D(gene name)|psi-mi:HSH2D(display_short)|uniprotkb:ALX(gene name synonym)|uniprotkb:Adaptor in lymphocytes of unknown function X(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693361|imex:IM-22632-107	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000171989(gene)|ensembl:ENST00000307144(transcript)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:Q9BYZ2|reactome:R-HSA-70268|refseq:NP_149972.1|entrezgene/locuslink:92483(identity)|refseq:NM_033195.2(identity)	ensembl:ENSP00000483354|ensembl:ENSP00000482604|ensembl:ENSG00000196684(gene)|ensembl:ENST00000613986(transcript)|ensembl:ENST00000616645(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR035047|interpro:IPR036860|rcsb pdb:2CS0|go:"GO:0005737"(cytoplasm)|refseq:NP_116244.1|refseq:NP_001278203.1|refseq:NM_032855.3(identity)|entrezgene/locuslink:84941(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:VktHnjwxkeayt64SWFxLAq4YlLQ9606	rogid:Y01YjkfU/oOtbz2TdQcnm+lBWhs9606	intact-crc:5FC39C0873F67151|rigid:JAY+AW05djmvicy7NmCmLW3qGYw	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WXH5	uniprotkb:Q9BYZ2	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	intact:EBI-1108377|uniprotkb:Q6DUY4|uniprotkb:Q96LI2|ensembl:ENSP00000302393	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:ldh6b_human(display_long)|uniprotkb:LDHAL6B(gene name)|psi-mi:LDHAL6B(display_short)|uniprotkb:LDHAL6(gene name synonym)|uniprotkb:LDHL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693376|imex:IM-22632-108	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	ensembl:ENSG00000171989(gene)|ensembl:ENST00000307144(transcript)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:Q9BYZ2|reactome:R-HSA-70268|refseq:NP_149972.1|entrezgene/locuslink:92483(identity)|refseq:NM_033195.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	rogid:VktHnjwxkeayt64SWFxLAq4YlLQ9606	intact-crc:10C46E3CD0DE1946|rigid:v2Wz0+mv8y9XwbrCjqno37FR8Yo	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXM7	uniprotkb:Q96JZ2	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	intact:EBI-3919324|intact:EBI-28973686|ensembl:ENSP00000482604|ensembl:ENSP00000483354|uniprotkb:B5ME72|uniprotkb:Q6ZNG7	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:hsh2d_human(display_long)|uniprotkb:HSH2D(gene name)|psi-mi:HSH2D(display_short)|uniprotkb:ALX(gene name synonym)|uniprotkb:Adaptor in lymphocytes of unknown function X(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693406|imex:IM-22632-110	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N|entrezgene/locuslink:65018(identity)|refseq:NM_032409.2(identity)	ensembl:ENSP00000483354|ensembl:ENSP00000482604|ensembl:ENSG00000196684(gene)|ensembl:ENST00000613986(transcript)|ensembl:ENST00000616645(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR035047|interpro:IPR036860|rcsb pdb:2CS0|go:"GO:0005737"(cytoplasm)|refseq:NP_116244.1|refseq:NP_001278203.1|refseq:NM_032855.3(identity)|entrezgene/locuslink:84941(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	rogid:Y01YjkfU/oOtbz2TdQcnm+lBWhs9606	intact-crc:DF47F62A03362440|rigid:z42I50QT56RmfOYvTXzX/awdpYs	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BSQ5	uniprotkb:Q8TEW6	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	intact:EBI-6918542|ensembl:ENSP00000344277|ensembl:ENSP00000455128|uniprotkb:O75209|uniprotkb:Q9BTP2|uniprotkb:Q9NVV3	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:dok4_human(display_long)|uniprotkb:DOK4(gene name)|psi-mi:DOK4(display_short)|uniprotkb:Downstream of tyrosine kinase 4(gene name synonym)|uniprotkb:Insulin receptor substrate 5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693421|imex:IM-22632-111	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N|refseq:NM_031443.3(identity)|entrezgene/locuslink:83605(identity)	ensembl:ENSG00000125170(gene)|ensembl:ENST00000340099(transcript)|ensembl:ENST00000569548(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0043410"(positive regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_060580.2|refseq:XP_005256100.1|entrezgene/locuslink:55715(identity)|refseq:NM_018110.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	rogid:Xc4aPsHtdQKj02Q5cqqgw29pSS09606	intact-crc:75913093E294E0DF|rigid:stzbqPSyL/LLqKnKP/O4C2M5pRA	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WXH5	uniprotkb:Q9BXM7	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693391|imex:IM-22632-109	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N|entrezgene/locuslink:65018(identity)|refseq:NM_032409.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	intact-crc:9DFDD39116D9D501|rigid:jeSxNnYq9fpGbm0LS1OKSzjQLqs	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q9BS75	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-10693436|intact:EBI-12812735	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:q9bs75_human(display_long)|uniprotkb:KLHL20(gene name)|psi-mi:KLHL20(display_short)|uniprotkb:hCG_23698(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693440|imex:IM-22632-112	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|entrezgene/locuslink:27252(identity)|refseq:NM_014458.3(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:CkJiQXWRaKpssKC+1jEOsq4s2PA9606	intact-crc:396DFF45F71EF164|rigid:jUJZTr6+FXfTdYfXrA9DxIaYkkM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BRX2	uniprotkb:Q92569	intact:EBI-1043580|uniprotkb:Q9GZS6|uniprotkb:Q9Y306|ensembl:ENSP00000274311	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:pelo_human(display_long)|uniprotkb:PELO(gene name)|psi-mi:PELO(display_short)|uniprotkb:CGI-17(orf name)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693455|imex:IM-22632-113	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152684(gene)|ensembl:ENST00000274311(transcript)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007049"(cell cycle)|go:"GO:0007492"(endoderm development)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0070966"(nuclear-transcribed mRNA catabolic process, no-go decay)|go:"GO:0071025"(RNA surveillance)|interpro:IPR004405(Probable translation factor pelota)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR029064|interpro:IPR038069|interpro:IPR042226|mint:Q9BRX2|rcsb pdb:1X52|rcsb pdb:5EO3|rcsb pdb:5LZW|rcsb pdb:5LZX|rcsb pdb:5LZY|rcsb pdb:5LZZ|refseq:NP_057030.3|entrezgene/locuslink:53918(identity)|refseq:NM_015946.4(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FGR (P09769), FYN (P06241), HCK (P08631), YES1 (P07947)."|comment:"The interaction failed to show if kinase-dead versions of ABL2 (P42684) or FYN (P06241) were used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:EZIi8JN2tu0u4oH06fOus3LKjoo9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:48FE1E0B7BAB3ADC|rigid:Y2maO/X3cW2UGVzylwMjrodF1Jg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q9BRT2	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-1054584|uniprotkb:B2R4I0|ensembl:ENSP00000476140	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:uqcc2_human(display_long)|uniprotkb:UQCC2(gene name)|psi-mi:UQCC2(display_short)|uniprotkb:Breast cancer-associated protein SGA-81M(gene name synonym)|uniprotkb:C6orf125(gene name synonym)|uniprotkb:MNF1(gene name synonym)|uniprotkb:Mitochondrial nucleoid factor 1(gene name synonym)|uniprotkb:Mitochondrial protein M19(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693471|imex:IM-22632-114	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	refseq:NP_115716.1|ensembl:ENSG00000137288(gene)|ensembl:ENST00000607484(transcript)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR037698|entrezgene/locuslink:84300(identity)|refseq:NM_032340.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:5bqVcfnTXOCOuCVCrEtzEaChT3Y9606	intact-crc:E67A0D18D985F367|rigid:WV8/wchdUti/YCAlWh3J4wStMsU	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5R372-2	uniprotkb:Q9BRT2	intact:EBI-10692254|ensembl:ENSP00000350027	intact:EBI-1054584|uniprotkb:B2R4I0|ensembl:ENSP00000476140	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:uqcc2_human(display_long)|uniprotkb:UQCC2(gene name)|psi-mi:UQCC2(display_short)|uniprotkb:Breast cancer-associated protein SGA-81M(gene name synonym)|uniprotkb:C6orf125(gene name synonym)|uniprotkb:MNF1(gene name synonym)|uniprotkb:Mitochondrial nucleoid factor 1(gene name synonym)|uniprotkb:Mitochondrial protein M19(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693486|imex:IM-22632-115	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	refseq:NP_115716.1|ensembl:ENSG00000137288(gene)|ensembl:ENST00000607484(transcript)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR037698|entrezgene/locuslink:84300(identity)|refseq:NM_032340.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FRK (P42685), JAK2 (O60674)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	rogid:5bqVcfnTXOCOuCVCrEtzEaChT3Y9606	intact-crc:4C0B9F20FFEDA1F1|rigid:84TByNxiPI39K8UiTjQ4a0pPJUg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99645	uniprotkb:P16885	intact:EBI-6677336|ensembl:ENSP00000261172|uniprotkb:A8K3M7|uniprotkb:Q8NEJ5	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	psi-mi:epyc_human(display_long)|uniprotkb:EPYC(gene name)|psi-mi:EPYC(display_short)|uniprotkb:DSPG3(gene name synonym)|uniprotkb:PGLB(gene name synonym)|uniprotkb:SLRR3B(gene name synonym)|uniprotkb:Dermatan sulfate proteoglycan 3(gene name synonym)|uniprotkb:Proteoglycan-Lb(gene name synonym)|uniprotkb:Small chondroitin/dermatan sulfate proteoglycan(gene name synonym)	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693516|imex:IM-22632-117	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083782(gene)|ensembl:ENST00000261172(transcript)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0031012"(extracellular matrix)|go:"GO:0060348"(bone development)|go:"GO:0061975"(articular cartilage development)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027217|interpro:IPR032675|interpro:IPR043547|refseq:NP_004941.2|refseq:NM_004950.4(identity)|entrezgene/locuslink:1833(identity)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FRK (P42685), FYN (P06241), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:1qzc4zJzP7s4IHAGdKeYCcWtEjs9606	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	intact-crc:76EFD75C7C54CBED|rigid:VGqIY2bds71xythqOBeq1dbIfLo	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q99645	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-6677336|ensembl:ENSP00000261172|uniprotkb:A8K3M7|uniprotkb:Q8NEJ5	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:epyc_human(display_long)|uniprotkb:EPYC(gene name)|psi-mi:EPYC(display_short)|uniprotkb:DSPG3(gene name synonym)|uniprotkb:PGLB(gene name synonym)|uniprotkb:SLRR3B(gene name synonym)|uniprotkb:Dermatan sulfate proteoglycan 3(gene name synonym)|uniprotkb:Proteoglycan-Lb(gene name synonym)|uniprotkb:Small chondroitin/dermatan sulfate proteoglycan(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693501|imex:IM-22632-116	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	ensembl:ENSG00000083782(gene)|ensembl:ENST00000261172(transcript)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0031012"(extracellular matrix)|go:"GO:0060348"(bone development)|go:"GO:0061975"(articular cartilage development)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027217|interpro:IPR032675|interpro:IPR043547|refseq:NP_004941.2|refseq:NM_004950.4(identity)|entrezgene/locuslink:1833(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:1qzc4zJzP7s4IHAGdKeYCcWtEjs9606	intact-crc:F721C5580CE8251D|rigid:bJdVRLZFMpN/rqf2dXQAoQIhMeM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99504	uniprotkb:P46108-2	intact:EBI-9089567|uniprotkb:Q99813|uniprotkb:O95463|uniprotkb:A8K190|uniprotkb:B4DIR7|uniprotkb:B4DNZ7|uniprotkb:Q8IVX7|ensembl:ENSP00000362978	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:eya3_human(display_long)|uniprotkb:EYA3(gene name)|psi-mi:EYA3(display_short)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693546|imex:IM-22632-119	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001981.2|ensembl:ENST00000373863|ensembl:ENSP00000362970|ensembl:ENSP00000362978|ensembl:ENST00000436342|ensembl:ENSP00000405587|ensembl:ENST00000540618|ensembl:ENSP00000442558|refseq:NP_001269489.1|refseq:NP_001269490.1|refseq:NP_001269491.1|dip:DIP-60448N|ensembl:ENSG00000158161(gene)|ensembl:ENST00000373871(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007601"(visual perception)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0048856"(anatomical structure development)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR006545(EYA)|interpro:IPR028472|interpro:IPR028479|interpro:IPR038102|interpro:IPR042577|reactome:R-HSA-5693565|refseq:NM_001990.3(identity)|entrezgene/locuslink:2140(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:FrzkCC1XK5NDTbrxH25HEKcj5P89606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:986842ECA9F53DF7|rigid:oyRDJXn2jqU0gc326a/KoxE+EG0	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q99619	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-2323209|uniprotkb:D3DUT0|uniprotkb:B7Z4W1|ensembl:ENSP00000428338|ensembl:ENSP00000430872	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:spsb2_human(display_long)|uniprotkb:SPSB2(gene name)|psi-mi:SPSB2(display_short)|uniprotkb:GRCC9(gene name synonym)|uniprotkb:SSB2(gene name synonym)|uniprotkb:Gene-rich cluster protein C9(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693531|imex:IM-22632-118	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_001139788.1|refseq:NP_116030.1|refseq:NP_001306599.1|ensembl:ENSG00000111671(gene)|ensembl:ENST00000523102(transcript)|ensembl:ENST00000524270(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036036|interpro:IPR037340|interpro:IPR043136|mint:Q99619|rcsb pdb:3EMW|rcsb pdb:5XN3|rcsb pdb:6DN5|rcsb pdb:6DN6|rcsb pdb:6JKJ|rcsb pdb:6JWM|rcsb pdb:6JWN|rcsb pdb:6KEY|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NM_001146316.1(identity)|entrezgene/locuslink:84727(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FES (P07332)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:d9ATBVBuRYT4OE5DV+pjGasS9qs9606	intact-crc:200AEABA1FEBF2A2|rigid:FD/bq5YQHQ4pqVjedrPniNx9GTs	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q96SW2-2	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-10693561|ensembl:ENSP00000412499	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693565|imex:IM-22632-120	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent)|entrezgene/locuslink:51185(identity)|refseq:NM_001173482.1(identity)	-	-	isoform-comment:No experimental confirmation available.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606	intact-crc:A1873997C7473C7E|rigid:ZLYqR1/+rZr+6SJqPfvGS0ONSuI	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96R05	uniprotkb:Q8WXH5	intact:EBI-2856326|uniprotkb:B2R517|uniprotkb:Q5SWJ4|ensembl:ENSP00000294435	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	psi-mi:ret7_human(display_long)|uniprotkb:RBP7(gene name)|psi-mi:RBP7(display_short)|uniprotkb:Cellular retinoic acid-binding protein 4(gene name synonym)|uniprotkb:Cellular retinoic acid-binding protein IV(gene name synonym)	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693580|imex:IM-22632-121	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443192.1|interpro:IPR031259|rcsb pdb:1LPJ|rcsb pdb:6AT8|rcsb pdb:6E6K|ensembl:ENSG00000162444(gene)|ensembl:ENST00000294435(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016918"(retinal binding)|go:"GO:0019841"(retinol binding)|interpro:IPR000463(Cytosolic fatty-acid binding)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|entrezgene/locuslink:116362(identity)|refseq:NM_052960.2(identity)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), PTK2 (Q05397)."|figure legend:Suppl. table S3, suppl. fig. S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:75axWxV5mnxExd1avjdlOUK4o2E9606	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	intact-crc:EB81B14510DAFCA8|rigid:xx2daNyRU+x+ug9JMXiLcab3ajI	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96JZ2	uniprotkb:Q96R05	intact:EBI-3919324|intact:EBI-28973686|ensembl:ENSP00000482604|ensembl:ENSP00000483354|uniprotkb:B5ME72|uniprotkb:Q6ZNG7	intact:EBI-2856326|uniprotkb:B2R517|uniprotkb:Q5SWJ4|ensembl:ENSP00000294435	psi-mi:hsh2d_human(display_long)|uniprotkb:HSH2D(gene name)|psi-mi:HSH2D(display_short)|uniprotkb:ALX(gene name synonym)|uniprotkb:Adaptor in lymphocytes of unknown function X(gene name synonym)	psi-mi:ret7_human(display_long)|uniprotkb:RBP7(gene name)|psi-mi:RBP7(display_short)|uniprotkb:Cellular retinoic acid-binding protein 4(gene name synonym)|uniprotkb:Cellular retinoic acid-binding protein IV(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693595|imex:IM-22632-122	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000483354|ensembl:ENSP00000482604|ensembl:ENSG00000196684(gene)|ensembl:ENST00000613986(transcript)|ensembl:ENST00000616645(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR035047|interpro:IPR036860|rcsb pdb:2CS0|go:"GO:0005737"(cytoplasm)|refseq:NP_116244.1|refseq:NP_001278203.1|refseq:NM_032855.3(identity)|entrezgene/locuslink:84941(identity)	refseq:NP_443192.1|interpro:IPR031259|rcsb pdb:1LPJ|rcsb pdb:6AT8|rcsb pdb:6E6K|ensembl:ENSG00000162444(gene)|ensembl:ENST00000294435(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016918"(retinal binding)|go:"GO:0019841"(retinol binding)|interpro:IPR000463(Cytosolic fatty-acid binding)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|entrezgene/locuslink:116362(identity)|refseq:NM_052960.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3, suppl. fig. S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Y01YjkfU/oOtbz2TdQcnm+lBWhs9606	rogid:75axWxV5mnxExd1avjdlOUK4o2E9606	intact-crc:7647DBF1B9789270|rigid:+zOloOwpu0WOONy4r7Lv6VuWcts	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96N03	uniprotkb:Q9BSQ5	intact:EBI-948213|uniprotkb:Q5JWZ4|uniprotkb:Q5JWZ5|uniprotkb:Q8ND45|uniprotkb:Q9BR37|uniprotkb:E1P5V7|ensembl:ENSP00000362560	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	psi-mi:vtm2l_human(display_long)|uniprotkb:C20orf102(gene name synonym)|uniprotkb:VSTM2L(gene name)|psi-mi:VSTM2L(display_short)	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693625|imex:IM-22632-124	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_542174.1|ensembl:ENSG00000132821(gene)|ensembl:ENST00000373461(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0030424"(axon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR027115|interpro:IPR036179|refseq:NM_080607.2(identity)|entrezgene/locuslink:128434(identity)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N|refseq:NM_031443.3(identity)|entrezgene/locuslink:83605(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:CMZ06pQwq1ob76PkF0ZdxdLJwwY9606	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	intact-crc:9D515C9319E42EEC|rigid:OW4hbb06Irg1xw9KD15p/94GzrU	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96R05	uniprotkb:Q92569	intact:EBI-2856326|uniprotkb:B2R517|uniprotkb:Q5SWJ4|ensembl:ENSP00000294435	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:ret7_human(display_long)|uniprotkb:RBP7(gene name)|psi-mi:RBP7(display_short)|uniprotkb:Cellular retinoic acid-binding protein 4(gene name synonym)|uniprotkb:Cellular retinoic acid-binding protein IV(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693610|imex:IM-22632-123	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443192.1|interpro:IPR031259|rcsb pdb:1LPJ|rcsb pdb:6AT8|rcsb pdb:6E6K|ensembl:ENSG00000162444(gene)|ensembl:ENST00000294435(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016918"(retinal binding)|go:"GO:0019841"(retinol binding)|interpro:IPR000463(Cytosolic fatty-acid binding)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|entrezgene/locuslink:116362(identity)|refseq:NM_052960.2(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:75axWxV5mnxExd1avjdlOUK4o2E9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:3B57A2E1CE639451|rigid:GQJdy08m0L8IK7bXQLHqKjbuRLo	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96KP4	uniprotkb:P46108-2	intact:EBI-1190734|uniprotkb:Q9BQ94|uniprotkb:Q9NVB4|uniprotkb:Q8WY59|uniprotkb:B3KUG4|uniprotkb:V9HWE5|ensembl:ENSP00000325548|ensembl:ENSP00000462311	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:cndp2_human(display_long)|uniprotkb:CNDP dipeptidase 2(gene name synonym)|uniprotkb:Glutamate carboxypeptidase-like protein 1(gene name synonym)|uniprotkb:Peptidase A(gene name synonym)|uniprotkb:HEL-S-13(gene name synonym)|uniprotkb:CNDP2(gene name)|psi-mi:CNDP2(display_short)|uniprotkb:CN2(gene name synonym)|uniprotkb:CPGL(gene name synonym)|uniprotkb:PEPA(gene name synonym)|uniprotkb:Threonyl dipeptidase(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693640|imex:IM-22632-125	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161971.1|refseq:NP_060705.2|refseq:XP_005266785.1|refseq:XP_006722566.1|refseq:XP_011524373.1|refseq:XP_011524374.1|ensembl:ENSG00000133313(gene)|ensembl:ENST00000324262(transcript)|ensembl:ENST00000579847(transcript)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0016805"(dipeptidase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070573"(metallodipeptidase activity)|go:"GO:0103046"(alanylglutamate dipeptidase activity)|interpro:IPR001261(ArgE/DapE/ACY1/CPG2/YscS, conserved site)|interpro:IPR002933(Peptidase M20)|interpro:IPR011650(Peptidase M20, dimerisation)|interpro:IPR017153(Glutathione degradosome, DUG1)|rcsb pdb:4RUH|reactome:R-HSA-174403|refseq:NM_018235.2(identity)|entrezgene/locuslink:55748(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:qAepmR2WYMtTL3WyP7AZz39LhkM9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:5182BC3A207331B3|rigid:VlC9RUy90c3yjJE8KED9AlFJ/jc	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:Q96IP4	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-954084|uniprotkb:Q5TF86|uniprotkb:Q8NFZ9|uniprotkb:Q9BW32|uniprotkb:Q9NXV5|uniprotkb:A8K7U4|ensembl:ENSP00000318298	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:tet5a_human(display_long)|uniprotkb:TENT5A(gene name)|psi-mi:TENT5A(display_short)|uniprotkb:C6orf37(gene name synonym)|uniprotkb:FAM46A(gene name synonym)|uniprotkb:HBV X-transactivated gene 11 protein(gene name synonym)|uniprotkb:HBV XAg-transactivated protein 11(gene name synonym)|uniprotkb:XTP11(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693670|imex:IM-22632-127	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	refseq:NP_060103.2|ensembl:ENSG00000112773(gene)|ensembl:ENST00000320172(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0048255"(mRNA stabilization)|go:"GO:1990817"(RNA adenylyltransferase activity)|interpro:IPR012937(Protein of unknown function DUF1693)|entrezgene/locuslink:55603(identity)|refseq:NM_017633.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:RoYW7NusMegWdnScxOvz6GI6Kjo9606	intact-crc:E49084EA76A5A735|rigid:S/ydXptquYVA2toac2ye1abZYMc	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96JZ2	uniprotkb:P46108-2	intact:EBI-3919324|intact:EBI-28973686|ensembl:ENSP00000482604|ensembl:ENSP00000483354|uniprotkb:B5ME72|uniprotkb:Q6ZNG7	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:hsh2d_human(display_long)|uniprotkb:HSH2D(gene name)|psi-mi:HSH2D(display_short)|uniprotkb:ALX(gene name synonym)|uniprotkb:Adaptor in lymphocytes of unknown function X(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693655|imex:IM-22632-126	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000483354|ensembl:ENSP00000482604|ensembl:ENSG00000196684(gene)|ensembl:ENST00000613986(transcript)|ensembl:ENST00000616645(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR035047|interpro:IPR036860|rcsb pdb:2CS0|go:"GO:0005737"(cytoplasm)|refseq:NP_116244.1|refseq:NP_001278203.1|refseq:NM_032855.3(identity)|entrezgene/locuslink:84941(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Y01YjkfU/oOtbz2TdQcnm+lBWhs9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:C1A48841E69EE85F|rigid:F+rZoM6yRSGHwcQY2FV9Vt+zNpI	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43405	uniprotkb:Q96IP4	intact:EBI-78302|ensembl:ENSP00000364898|ensembl:ENSP00000364907	intact:EBI-954084|uniprotkb:Q5TF86|uniprotkb:Q8NFZ9|uniprotkb:Q9BW32|uniprotkb:Q9NXV5|uniprotkb:A8K7U4|ensembl:ENSP00000318298	psi-mi:ksyk_human(display_long)|uniprotkb:SYK(gene name)|psi-mi:SYK(display_short)|uniprotkb:Spleen tyrosine kinase(gene name synonym)|uniprotkb:p72-Syk(gene name synonym)	psi-mi:tet5a_human(display_long)|uniprotkb:TENT5A(gene name)|psi-mi:TENT5A(display_short)|uniprotkb:C6orf37(gene name synonym)|uniprotkb:FAM46A(gene name synonym)|uniprotkb:HBV X-transactivated gene 11 protein(gene name synonym)|uniprotkb:HBV XAg-transactivated protein 11(gene name synonym)|uniprotkb:XTP11(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693685|imex:IM-22632-128	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128524.1|refseq:NP_001167638.1|refseq:NP_001167639.1|refseq:NP_003168.2|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043313"(regulation of neutrophil degranulation)|go:"GO:0043366"(beta selection)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090237"(regulation of arachidonic acid secretion)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43405|rcsb pdb:1A81|rcsb pdb:1CSY|rcsb pdb:1CSZ|rcsb pdb:1XBA|rcsb pdb:1XBB|rcsb pdb:1XBC|rcsb pdb:3BUW|rcsb pdb:3EMG|rcsb pdb:3FQE|rcsb pdb:3FQH|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019815"(B cell receptor complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0032009"(early phagosome)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032752"(positive regulation of interleukin-3 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032928"(regulation of superoxide anion generation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0016170"(interleukin-15 receptor binding)|rcsb pdb:3FQS|rcsb pdb:3SRV|rcsb pdb:3TUB|rcsb pdb:3TUC|rcsb pdb:3TUD|rcsb pdb:3VF8|rcsb pdb:3VF9|rcsb pdb:4DFL|rcsb pdb:4DFN|rcsb pdb:4F4P|rcsb pdb:4FL1|rcsb pdb:4FL2|rcsb pdb:4FL3|rcsb pdb:4FYN|rcsb pdb:4FYO|rcsb pdb:4FZ6|rcsb pdb:4FZ7|rcsb pdb:4GFG|rcsb pdb:4I0R|ensembl:ENSG00000165025(gene)|ensembl:ENST00000375746(transcript)|ensembl:ENST00000375754(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002554"(serotonin secretion by platelet)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|rcsb pdb:4I0S|rcsb pdb:4I0T|rcsb pdb:4PUZ|rcsb pdb:4PV0|rcsb pdb:4PX6|rcsb pdb:4RSS|rcsb pdb:4RX7|rcsb pdb:4RX8|rcsb pdb:4RX9|rcsb pdb:4WNM|rcsb pdb:4XG2|rcsb pdb:4XG3|rcsb pdb:5TIU|rcsb pdb:5TR6|rcsb pdb:5TT7|rcsb pdb:5Y5T|rcsb pdb:5Y5U|rcsb pdb:6HM6|rcsb pdb:6HM7|rcsb pdb:6SSB|rcsb pdb:6VOV|rcsb pdb:6ZC0|rcsb pdb:6ZCP|rcsb pdb:6ZCQ|rcsb pdb:6ZCR|rcsb pdb:6ZCS|rcsb pdb:6ZCU|rcsb pdb:6ZCX|rcsb pdb:6ZCY|rcsb pdb:4XG4|reactome:R-HSA-114604|reactome:R-HSA-2029481|reactome:R-HSA-2029482|rcsb pdb:4XG7|rcsb pdb:4XG8|rcsb pdb:4XG9|rcsb pdb:4YJO|rcsb pdb:4YJP|rcsb pdb:4YJQ|rcsb pdb:4YJR|rcsb pdb:4YJS|rcsb pdb:4YJT|rcsb pdb:4YJU|rcsb pdb:4YJV|rcsb pdb:5C26|rcsb pdb:5C27|rcsb pdb:5CXH|rcsb pdb:5CXZ|rcsb pdb:5CY3|rcsb pdb:5GHV|rcsb pdb:5LMA|rcsb pdb:4XG6|rcsb pdb:5LMB|rcsb pdb:5T68|refseq:XP_011517248.1|refseq:XP_005252204.1|reactome:R-HSA-2029485|reactome:R-HSA-2424491|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9020558|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374|reactome:R-HSA-983695|dip:DIP-253N|entrezgene/locuslink:6850(identity)|refseq:NM_001174167.2(identity)	refseq:NP_060103.2|ensembl:ENSG00000112773(gene)|ensembl:ENST00000320172(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0048255"(mRNA stabilization)|go:"GO:1990817"(RNA adenylyltransferase activity)|interpro:IPR012937(Protein of unknown function DUF1693)|entrezgene/locuslink:55603(identity)|refseq:NM_017633.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FES (P07332)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SAOtCMFKG07Wej573EklHjusYVA9606	rogid:RoYW7NusMegWdnScxOvz6GI6Kjo9606	intact-crc:647F6B20AC566A74|rigid:NntW2da6K1qNXXzpu8RKR7tIL7M	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96ID7	uniprotkb:P62993	intact:EBI-10693700|intact:EBI-12932467	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:q96id7_human(display_long)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693703|imex:IM-22632-129	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	entrezgene/locuslink:1870(identity)|refseq:NM_004091.3(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:JdiIb6xsGAVQW//ms2Dj9fdTz+U9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:1A858379FFD19A77|rigid:YUYpSDXflb23KSQhz+6pKdugDVk	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12929	uniprotkb:Q96GT9	intact:EBI-375576|uniprotkb:A6NMC3|ensembl:ENSP00000281172|ensembl:ENSP00000441867|ensembl:ENSP00000442388|ensembl:ENSP00000494689|ensembl:ENSP00000494842|ensembl:ENSP00000495722|ensembl:ENSP00000495824|ensembl:ENSP00000495956|ensembl:ENSP00000496406|ensembl:ENSP00000496516|uniprotkb:Q8N6J0|uniprotkb:B4DX66|uniprotkb:A8K6W2|uniprotkb:A8KA66	intact:EBI-750167|uniprotkb:Q5HYR4|ensembl:ENSP00000286049	psi-mi:eps8_human(display_long)|uniprotkb:EPS8(gene name)|psi-mi:EPS8(display_short)	psi-mi:xage2_human(display_long)|uniprotkb:Cancer/testis antigen 12.2(gene name synonym)|uniprotkb:XAGE2(gene name)|psi-mi:XAGE2(display_short)|uniprotkb:GAGED3(gene name synonym)|uniprotkb:G antigen family D member 3(gene name synonym)|uniprotkb:XAGE2B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693718|imex:IM-22632-130	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000645775(transcript)|ensembl:ENST00000646828(transcript)|ensembl:ENSG00000151491(gene)|ensembl:ENST00000646918(transcript)|ensembl:ENST00000647087(transcript)|ensembl:ENST00000647224(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010458"(exit from mitosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0030426"(growth cone)|go:"GO:0030832"(regulation of actin filament length)|go:"GO:0031267"(small GTPase binding)|ensembl:ENST00000281172(transcript)|ensembl:ENST00000543523(transcript)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|ensembl:ENST00000543612(transcript)|ensembl:ENST00000642278(transcript)|ensembl:ENST00000644374(transcript)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030222|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q12929|rcsb pdb:2E8M|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_004438.3|dip:DIP-32859N|entrezgene/locuslink:2059(identity)|refseq:NM_004447.5(identity)	refseq:NP_570133.1|refseq:XP_011529138.1|ensembl:ENSG00000155622(gene)|ensembl:ENST00000286049(transcript)|interpro:IPR008625(GAGE)|interpro:IPR031320|entrezgene/locuslink:728242(identity)|refseq:NM_130777.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ulBgb+4uZ7XrN4bLogRtd9I5AbY9606	rogid:oEfLIl6RmCLabVT5MZpMg6uxBXk9606	intact-crc:2DEF6DD1229B729D|rigid:kDtfk1DIrao3Zy/e7kb5OSNAh5o	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96DZ7	uniprotkb:P40763-2	intact:EBI-6448756|ensembl:ENSP00000273695|uniprotkb:E9PH22|uniprotkb:B2RV20|uniprotkb:Q336K7	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:t4s19_human(display_long)|uniprotkb:Osteoclast maturation-associated gene 4 protein(gene name synonym)|uniprotkb:Tetraspan membrane protein OCTM4(gene name synonym)|uniprotkb:TM4SF19(gene name)|psi-mi:TM4SF19(display_short)|uniprotkb:OCTM4(gene name synonym)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693733|imex:IM-22632-131	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145107(gene)|ensembl:ENST00000273695(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008661(L6 membrane)|refseq:NP_001191827.1|refseq:NP_612470.2|refseq:NM_138461.3(identity)|entrezgene/locuslink:116211(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	-	isoform-comment:Contains a phosphotyrosine at position 704.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:0pi3aVpxzi5UX4o8+w7qSluVefU9606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:3B78369B799D3B19|rigid:32u/GAeQSnHLfMfuScxzr2Oz/V0	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96DZ7	uniprotkb:P46108-2	intact:EBI-6448756|ensembl:ENSP00000273695|uniprotkb:E9PH22|uniprotkb:B2RV20|uniprotkb:Q336K7	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:t4s19_human(display_long)|uniprotkb:Osteoclast maturation-associated gene 4 protein(gene name synonym)|uniprotkb:Tetraspan membrane protein OCTM4(gene name synonym)|uniprotkb:TM4SF19(gene name)|psi-mi:TM4SF19(display_short)|uniprotkb:OCTM4(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693763|imex:IM-22632-133	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145107(gene)|ensembl:ENST00000273695(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008661(L6 membrane)|refseq:NP_001191827.1|refseq:NP_612470.2|refseq:NM_138461.3(identity)|entrezgene/locuslink:116211(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:0pi3aVpxzi5UX4o8+w7qSluVefU9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:5E56FA00F985BB7B|rigid:yrwSRn43USuHqynsW2FoitXpcoI	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96DZ7	uniprotkb:P40763	intact:EBI-6448756|ensembl:ENSP00000273695|uniprotkb:E9PH22|uniprotkb:B2RV20|uniprotkb:Q336K7	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:t4s19_human(display_long)|uniprotkb:Osteoclast maturation-associated gene 4 protein(gene name synonym)|uniprotkb:Tetraspan membrane protein OCTM4(gene name synonym)|uniprotkb:TM4SF19(gene name)|psi-mi:TM4SF19(display_short)|uniprotkb:OCTM4(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693748|imex:IM-22632-132	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145107(gene)|ensembl:ENST00000273695(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008661(L6 membrane)|refseq:NP_001191827.1|refseq:NP_612470.2|refseq:NM_138461.3(identity)|entrezgene/locuslink:116211(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:0pi3aVpxzi5UX4o8+w7qSluVefU9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:323FB8115556F6B8|rigid:nkbM5+A8K0W7BIL/VMRbnL8E3ew	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92854	uniprotkb:P46108	intact:EBI-2855119|uniprotkb:Q7Z5S4|uniprotkb:B2RPM6|uniprotkb:Q8N8B0|ensembl:ENSP00000348822|ensembl:ENSP00000388768|ensembl:ENSP00000405102|ensembl:ENSP00000416523	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:sem4d_human(display_long)|uniprotkb:SEMA4D(gene name)|psi-mi:SEMA4D(display_short)|uniprotkb:C9orf164(gene name synonym)|uniprotkb:CD100(gene name synonym)|uniprotkb:SEMAJ(gene name synonym)|uniprotkb:A8(gene name synonym)|uniprotkb:BB18(gene name synonym)|uniprotkb:GR3(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693778|imex:IM-22632-134	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011516425.1|refseq:XP_011516436.1|refseq:XP_011516426.1|refseq:XP_011516427.1|refseq:XP_011516429.1|refseq:XP_011516430.1|refseq:XP_011516431.1|refseq:XP_011516432.1|refseq:XP_011516433.1|refseq:XP_011516435.1|refseq:XP_016869682.1|refseq:XP_016869683.1|refseq:XP_016869684.1|refseq:XP_016869685.1|refseq:XP_016869686.1|refseq:XP_016869687.1|refseq:NP_001135759.1|refseq:NP_006369.3|refseq:XP_005251711.1|dip:DIP-59221N|ensembl:ENSG00000187764(gene)|ensembl:ENST00000356444(transcript)|ensembl:ENST00000422704(transcript)|ensembl:ENST00000438547(transcript)|ensembl:ENST00000450295(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031344"(regulation of cell projection organization)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0070486"(leukocyte aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1900220"(semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis)|go:"GO:1905704"(positive regulation of inhibitory synapse assembly)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|rcsb pdb:1OLZ|rcsb pdb:3OL2|reactome:R-HSA-416550|reactome:R-HSA-416572|reactome:R-HSA-416700|refseq:NM_006378.3(identity)|entrezgene/locuslink:10507(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:2Xa00fuwt0CCvnzXwe5Q0ukApRc9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:E0863A32445C2B13|rigid:4aALD4CzRV8/tYYuTsGFXsS1JZw	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:Q92574	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693793|imex:IM-22632-135	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1|entrezgene/locuslink:7248(identity)|refseq:NM_001162426.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:D6355BC30764D095|rigid:sefWc2uB24Pv+L3Bbzz5oRzDcOk	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92574	uniprotkb:Q96JZ2	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-3919324|intact:EBI-28973686|ensembl:ENSP00000482604|ensembl:ENSP00000483354|uniprotkb:B5ME72|uniprotkb:Q6ZNG7	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:hsh2d_human(display_long)|uniprotkb:HSH2D(gene name)|psi-mi:HSH2D(display_short)|uniprotkb:ALX(gene name synonym)|uniprotkb:Adaptor in lymphocytes of unknown function X(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693808|imex:IM-22632-136	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1|entrezgene/locuslink:7248(identity)|refseq:NM_001162426.1(identity)	ensembl:ENSP00000483354|ensembl:ENSP00000482604|ensembl:ENSG00000196684(gene)|ensembl:ENST00000613986(transcript)|ensembl:ENST00000616645(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR035047|interpro:IPR036860|rcsb pdb:2CS0|go:"GO:0005737"(cytoplasm)|refseq:NP_116244.1|refseq:NP_001278203.1|refseq:NM_032855.3(identity)|entrezgene/locuslink:84941(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:Y01YjkfU/oOtbz2TdQcnm+lBWhs9606	intact-crc:1C322DEDA7B04AE4|rigid:vjugl2c3GydAVGrii2DT/i74kJk	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:Q92569	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693823|imex:IM-22632-137	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FRK (P42685), FYN (P06241), HCK (P08631), SRC (P12931), SYK (P43405), YES1 (P07947)."|comment:"The interaction failed to show if kinase-dead versions of ABL2 (P42684) or FYN (P06241) were used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:52EAD9876F08352E|rigid:H45MGP2sseKC/dza30HFhS26Qqg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:P16333	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-389883|uniprotkb:B7Z751|ensembl:ENSP00000288986|ensembl:ENSP00000417273|intact:EBI-3448658|uniprotkb:D3DNE3	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:nck1_human(display_long)|uniprotkb:NCK1(gene name)|psi-mi:NCK1(display_short)|uniprotkb:NCK(gene name synonym)|uniprotkb:NCK adaptor protein 1(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693839|imex:IM-22632-138	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_001278928.1|ensembl:ENSG00000158092(gene)|ensembl:ENST00000288986(transcript)|ensembl:ENST00000481752(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007172"(signal complex assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|refseq:NP_001177725.1|refseq:NP_006144.1|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|mint:P16333|rcsb pdb:2CI8|rcsb pdb:2CI9|rcsb pdb:2CUB|rcsb pdb:2JS0|rcsb pdb:2JS2|rcsb pdb:2JW4|rcsb pdb:5QU1|rcsb pdb:5QU2|rcsb pdb:5QU3|rcsb pdb:5QU4|rcsb pdb:5QU5|rcsb pdb:5QU6|rcsb pdb:5QU7|rcsb pdb:5QU8|rcsb pdb:5QUA|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-373753|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9664422|reactome:R-HSA-983695|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|dip:DIP-639N|entrezgene/locuslink:4690(identity)|refseq:NM_006153.5(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), SYK (P43405)."|comment:"The interaction failed to show if a kinase-dead version of ABL2 (P42684) was used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:UzgLYRQQ9VjN7eKkgn76At/7cSA9606	intact-crc:B4A70FC033DEA6E5|rigid:Ym2EM8XfUd8Kpj61wy17hzRbBaQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96JZ2	uniprotkb:Q92569	intact:EBI-3919324|intact:EBI-28973686|ensembl:ENSP00000482604|ensembl:ENSP00000483354|uniprotkb:B5ME72|uniprotkb:Q6ZNG7	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:hsh2d_human(display_long)|uniprotkb:HSH2D(gene name)|psi-mi:HSH2D(display_short)|uniprotkb:ALX(gene name synonym)|uniprotkb:Adaptor in lymphocytes of unknown function X(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693855|imex:IM-22632-139	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000483354|ensembl:ENSP00000482604|ensembl:ENSG00000196684(gene)|ensembl:ENST00000613986(transcript)|ensembl:ENST00000616645(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR035047|interpro:IPR036860|rcsb pdb:2CS0|go:"GO:0005737"(cytoplasm)|refseq:NP_116244.1|refseq:NP_001278203.1|refseq:NM_032855.3(identity)|entrezgene/locuslink:84941(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), YES1 (P07947)."|comment:"The interaction failed to show if a kinase-dead version of FYN (P06241) was used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Y01YjkfU/oOtbz2TdQcnm+lBWhs9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:96D595940A75875F|rigid:2rTPfMRnBAveVHi2e5bBOVy8Xcg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:Q92569	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693871|imex:IM-22632-140	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3, suppl. fig. S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:1D1246BC36B86835|rigid:9IhtipCdg1OD6tsl6/DeyNKPvC0	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:P46108	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693917|imex:IM-22632-143	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:8B3E541E63288077|rigid:rRiTpdQzDV8gPyvEI+eLKxP+Ohk	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q92569	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693902|imex:IM-22632-142	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:84FD8FB1594ECB9F|rigid:gPgLN8riqP1Ovr8YBlWjqa/T7Vs	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35568	uniprotkb:Q92569	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693886|imex:IM-22632-141	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772|refseq:NM_005544.2(identity)|entrezgene/locuslink:3667(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FRK (P42685), FYN (P06241), HCK (P08631), PTK2 (Q05397), SRC (P12931), TNK1 (Q13470), YES1 (P07947)."|comment:"The interaction failed to show if kinase-dead versions of FYN (P06241), ABL2 (P42684), FRK (P42685), PTK2 (Q05397) or TNK1 (Q13470) were used."|figure legend:Suppl. table S3, fig. 1B, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:46C5D2BC638612AF|rigid:JTCBBkGf9heSVjXJrI8dklyOaoA	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q92569	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693932|imex:IM-22632-144	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:58E405BCB9F58124|rigid:8u9YYq6pOBuCfFBRda37Yfi2LP0	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763-2	uniprotkb:Q92569	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693947|imex:IM-22632-145	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	isoform-comment:Contains a phosphotyrosine at position 704.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:BD860587761531F7|rigid:LeQAOWxWF+hVz2SCoay8BQ8vt8c	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:Q92569	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693962|imex:IM-22632-146	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	crc64:6C00632211C8012D	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:F4E96918192433E9|rigid:LjLBf25PFr/wMjiY4SIdMT+f3Z8	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42684-3	uniprotkb:Q92569	intact:EBI-10693977|ensembl:ENSP00000423578	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:p42684-3(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym)|uniprotkb:1ALCTL(isoform synonym)|uniprotkb:IC(isoform synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693982|imex:IM-22632-147	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143322(gene)|ensembl:ENST00000512653(transcript)|intact:EBI-1102694(isoform-parent)|uniprotkb:P42684-3(isoform-parent)|refseq:NM_005158.4(identity)|entrezgene/locuslink:27(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:gLzqA1k71ptItAHexZD/6P1Ilos9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:68BD1608044189DA|rigid:6SBxBOH38zYawcuVRWVpiMAS7y8	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12931	uniprotkb:Q92569	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694027|imex:IM-22632-150	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N|refseq:NM_198291.2(identity)|entrezgene/locuslink:6714(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:0DA8AA6FE151E93E|rigid:Wn7dCOQmsibkP99UtrupEHsxsqg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08631-2	uniprotkb:Q92569	intact:EBI-9834454|ensembl:ENSP00000429848|ensembl:ENSP00000486627	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:p08631-2(display_long)|uniprotkb:p59-HCK(isoform synonym)|uniprotkb:p59Hck(isoform synonym)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694012|imex:IM-22632-149	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:P08631-2(isoform-parent)|intact:EBI-346340(isoform-parent)|ensembl:ENSG00000101336(gene)|ensembl:ENST00000520553(transcript)|ensembl:ENST00000629881(transcript)|entrezgene/locuslink:3055(identity)|refseq:NM_001172129.1(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	isoform-comment:Initiator Met-1 is removed. Contains a N-myristoyl glycine at position 2. Contains a S-palmitoyl cysteine at position 3.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:qSgfntp+jqdyi7qsc7u7UA7ylO09606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:92D5405A30EE2FC5|rigid:qfJOe/FsOciLbpYBqVn5AZMH/88	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:O43559	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10693997|imex:IM-22632-148	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	intact-crc:523E2E314BF5A53A|rigid:fscct1zSG/oVWU61u/B9+IW1+EA	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WZ19	uniprotkb:P46108	intact:EBI-742916|ensembl:ENSP00000311202|ensembl:ENSP00000455785|uniprotkb:Q96P93|uniprotkb:Q96SA1|uniprotkb:A8K0R5	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:bacd1_human(display_long)|uniprotkb:Polymerase delta-interacting protein 1(gene name synonym)|uniprotkb:TNFAIP1-like protein(gene name synonym)|uniprotkb:KCTD13(gene name)|psi-mi:KCTD13(display_short)|uniprotkb:PDIP1(gene name synonym)|uniprotkb:POLDIP1(gene name synonym)|uniprotkb:FKSG86(orf name)|uniprotkb:PP6832(orf name)|uniprotkb:BACURD1(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein KCTD13(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694057|imex:IM-22632-152	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_849194.1|ensembl:ENSG00000174943(gene)|ensembl:ENST00000308768(transcript)|ensembl:ENST00000568000(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q8WZ19|rcsb pdb:4UIJ|reactome:R-HSA-9696264|reactome:R-HSA-9696270|entrezgene/locuslink:253980(identity)|refseq:NM_178863.4(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:hAH5yJEoda0H1anmnSXWHO0o1ZM9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:6FCC52DC7BA61ECF|rigid:1Y1/pIVypIqqkBDyKU8H6ZmXIU8	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q8WZ19	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-742916|ensembl:ENSP00000311202|ensembl:ENSP00000455785|uniprotkb:Q96P93|uniprotkb:Q96SA1|uniprotkb:A8K0R5	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:bacd1_human(display_long)|uniprotkb:Polymerase delta-interacting protein 1(gene name synonym)|uniprotkb:TNFAIP1-like protein(gene name synonym)|uniprotkb:KCTD13(gene name)|psi-mi:KCTD13(display_short)|uniprotkb:PDIP1(gene name synonym)|uniprotkb:POLDIP1(gene name synonym)|uniprotkb:FKSG86(orf name)|uniprotkb:PP6832(orf name)|uniprotkb:BACURD1(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein KCTD13(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694042|imex:IM-22632-151	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_849194.1|ensembl:ENSG00000174943(gene)|ensembl:ENST00000308768(transcript)|ensembl:ENST00000568000(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q8WZ19|rcsb pdb:4UIJ|reactome:R-HSA-9696264|reactome:R-HSA-9696270|entrezgene/locuslink:253980(identity)|refseq:NM_178863.4(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:hAH5yJEoda0H1anmnSXWHO0o1ZM9606	intact-crc:E8BDDCEF8B362901|rigid:vKatw7RiTQWBNg5qsWiVvkS31Ps	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WY64	uniprotkb:Q9UN19	intact:EBI-6952711|ensembl:ENSP00000349298|uniprotkb:Q9BU73|uniprotkb:Q9UHE7|intact:MINT-8162265|uniprotkb:Q5TIA4|uniprotkb:Q9NRL9|intact:MINT-268789	intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602	psi-mi:mylip_human(display_long)|uniprotkb:MYLIP(gene name)|psi-mi:MYLIP(display_short)|uniprotkb:BZF1(gene name synonym)|uniprotkb:IDOL(gene name synonym)|uniprotkb:Inducible degrader of the LDL-receptor(gene name synonym)|uniprotkb:Myosin regulatory light chain interacting protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MYLIP(gene name synonym)|uniprotkb:BM-023(orf name)|uniprotkb:PP5242(orf name)	psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694072|imex:IM-22632-153	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000007944(gene)|ensembl:ENST00000356840(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031648"(protein destabilization)|go:"GO:0032803"(regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0005886"(plasma membrane)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041790|mint:Q8WY64|rcsb pdb:2YHN|rcsb pdb:2YHO|rcsb pdb:6QLY|rcsb pdb:6QLZ|reactome:R-HSA-8866427|reactome:R-HSA-9031525|reactome:R-HSA-983168|refseq:NP_037394.2|entrezgene/locuslink:29116(identity)|refseq:NM_013262.3(identity)	refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695|entrezgene/locuslink:27071(identity)|refseq:NM_014395.2(identity)	-	comment:mint|comment:homomint|function:"E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC). Stable or transient overexpression of MIR induces proteasomal degradation of MRLC inhibiting neurite outgrowth in presence of NGF. MIR counteracts the stabilization of MRLC by MIR-interacting saposin-like protein (MSAP/TMEM4) and reduces MSAP-stimulated neurite outgrowth"	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:kkDkk49icU/zPJmjNiiaQ5GIx+w9606	rogid:YYI49xKbndaB1MfL/QEovp2BF009606	intact-crc:C7669A71684EBC9D|rigid:6gmMIgUR4GWg/Ys0mAWMOEQS9Fg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WY64	uniprotkb:P46108-2	intact:EBI-6952711|ensembl:ENSP00000349298|uniprotkb:Q9BU73|uniprotkb:Q9UHE7|intact:MINT-8162265|uniprotkb:Q5TIA4|uniprotkb:Q9NRL9|intact:MINT-268789	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:mylip_human(display_long)|uniprotkb:MYLIP(gene name)|psi-mi:MYLIP(display_short)|uniprotkb:BZF1(gene name synonym)|uniprotkb:IDOL(gene name synonym)|uniprotkb:Inducible degrader of the LDL-receptor(gene name synonym)|uniprotkb:Myosin regulatory light chain interacting protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MYLIP(gene name synonym)|uniprotkb:BM-023(orf name)|uniprotkb:PP5242(orf name)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694087|imex:IM-22632-154	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000007944(gene)|ensembl:ENST00000356840(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031648"(protein destabilization)|go:"GO:0032803"(regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0005886"(plasma membrane)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041790|mint:Q8WY64|rcsb pdb:2YHN|rcsb pdb:2YHO|rcsb pdb:6QLY|rcsb pdb:6QLZ|reactome:R-HSA-8866427|reactome:R-HSA-9031525|reactome:R-HSA-983168|refseq:NP_037394.2|entrezgene/locuslink:29116(identity)|refseq:NM_013262.3(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	comment:mint|comment:homomint|function:"E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC). Stable or transient overexpression of MIR induces proteasomal degradation of MRLC inhibiting neurite outgrowth in presence of NGF. MIR counteracts the stabilization of MRLC by MIR-interacting saposin-like protein (MSAP/TMEM4) and reduces MSAP-stimulated neurite outgrowth"	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:kkDkk49icU/zPJmjNiiaQ5GIx+w9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:7E2D78875E5D2109|rigid:1VpTy/d88G8B6xAHSIh6TJJEBHs	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WVJ9	uniprotkb:Q9BSQ5	intact:EBI-1797313|uniprotkb:Q3SYL6|ensembl:ENSP00000405176|ensembl:ENSP00000482581|ensembl:ENSP00000500440|ensembl:ENSP00000500609	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	psi-mi:twst2_human(display_long)|uniprotkb:Dermis-expressed protein 1(gene name synonym)|uniprotkb:TWIST2(gene name)|psi-mi:TWIST2(display_short)|uniprotkb:DERMO1(gene name synonym)|uniprotkb:BHLHA39(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 39(gene name synonym)	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694132|imex:IM-22632-157	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258822.1|refseq:NP_476527.1|ensembl:ENSG00000233608(gene)|ensembl:ENSG00000288335(gene)|ensembl:ENST00000448943(transcript)|ensembl:ENST00000612363(transcript)|ensembl:ENST00000671947(transcript)|ensembl:ENST00000673387(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032502"(developmental process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015789(Twist)|interpro:IPR036638|reactome:R-HSA-8878166|entrezgene/locuslink:117581(identity)|refseq:NM_057179.2(identity)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N|refseq:NM_031443.3(identity)|entrezgene/locuslink:83605(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813), FRK (P42685), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:IYIpMXYdrqllQqS+Ftz+P0xtk789606	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	intact-crc:381C75C339EA8C33|rigid:q28n3k04QLjqaBiKQ3h7blFJNmI	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WXH5	uniprotkb:P62993	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694117|imex:IM-22632-156	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:9D2B197F87DFEDA4|rigid:HSH4BIaK53MwkzzXpWiE6XD6pw8	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q8WXH5	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694102|imex:IM-22632-155	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	intact-crc:74038F4AA81A8A3A|rigid:7zpzclblMW0lSAxlChMrga4jppg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q8WVB6	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-1237523|uniprotkb:Q7Z6Y6|uniprotkb:Q9BR83|uniprotkb:Q9BRG5|uniprotkb:Q9H7K3|uniprotkb:B7ZBA2|uniprotkb:Q7Z6Y4|uniprotkb:D3DU68|intact:EBI-28984493|ensembl:ENSP00000262315	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:ctf18_human(display_long)|uniprotkb:CHTF18(gene name)|psi-mi:CHTF18(display_short)|uniprotkb:CTF18(gene name synonym)|uniprotkb:C16orf41(gene name synonym)|uniprotkb:CHL12(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694162|imex:IM-22632-159	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_071375.1|refseq:XP_011520875.1|ensembl:ENSP00000262315|ensembl:ENST00000455171|ensembl:ENSP00000406252|refseq:XP_005255528.1|ensembl:ENSG00000127586(gene)|ensembl:ENST00000262315(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0031390"(Ctf18 RFC-like complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR027417|mint:Q8WVB6|reactome:R-HSA-174411|entrezgene/locuslink:63922(identity)|refseq:NM_022092.2(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:cIuesMN9KfDCiavKy3XvnYV+IA09606	intact-crc:2A782529B171C446|rigid:2J+G50/HDukuFTN8BPmBZBdBhg0	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WVF5	uniprotkb:P16591	intact:EBI-741463|ensembl:ENSP00000368402|uniprotkb:Q5W0P9	intact:EBI-1380661|uniprotkb:B4DSQ2|uniprotkb:B2RCR4|uniprotkb:H2FLB8|ensembl:ENSP00000281092	psi-mi:kctd4_human(display_long)|uniprotkb:KCTD4(gene name)|psi-mi:KCTD4(display_short)	psi-mi:fer_human(display_long)|uniprotkb:Feline encephalitis virus-related kinase FER(gene name synonym)|uniprotkb:Fujinami poultry sarcoma/Feline sarcoma-related protein Fer(gene name synonym)|uniprotkb:FER(gene name)|psi-mi:FER(display_short)|uniprotkb:TYK3(gene name synonym)|uniprotkb:Proto-oncogene c-Fer(gene name synonym)|uniprotkb:Tyrosine kinase 3(gene name synonym)|uniprotkb:p94-Fer(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694147|imex:IM-22632-158	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180332(gene)|ensembl:ENST00000379108(transcript)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|refseq:NP_940686.2|entrezgene/locuslink:386618(identity)|refseq:NM_198404.2(identity)	refseq:NP_005237.2|refseq:XP_016864719.1|refseq:XP_016864720.1|refseq:NP_001294957.1|refseq:NP_001294960.1|refseq:NP_001294967.1|refseq:XP_011541573.1|ensembl:ENSG00000151422(gene)|ensembl:ENST00000281092(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033007"(negative regulation of mast cell activation involved in immune response)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0036119"(response to platelet-derived growth factor)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038109"(Kit signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050904"(diapedesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR028539|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|interpro:IPR037452|mint:P16591|rcsb pdb:2KK6|rcsb pdb:6KC4|reactome:R-HSA-1433557|entrezgene/locuslink:2241(identity)|refseq:NM_005246.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:03cd1lqmT8fReXzYqjrKSWUdqY89606	rogid:De5RYVRGihPHGxaflmxR8W9jC8M9606	intact-crc:D6FC877E0C96941F|rigid:bQbEl3I+vF/JbNcxPk2xKW10vC0	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q8TD91-2	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-10694180|ensembl:ENSP00000386566|ensembl:ENSP00000440444	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:q8td91-2(display_long)|uniprotkb:MAGEC3(gene name)|psi-mi:MAGEC3(display_short)|uniprotkb:Cancer/testis antigen 7.2(gene name synonym)|uniprotkb:HCA2(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 2(gene name synonym)|uniprotkb:MAGE-C3 antigen(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694177|imex:IM-22632-160	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	intact:EBI-10757207(isoform-parent)|ensembl:ENSG00000165509(gene)|ensembl:ENST00000409007(transcript)|ensembl:ENST00000544766(transcript)|uniprotkb:Q8TD91-2(isoform-parent)|entrezgene/locuslink:139081(identity)|refseq:NM_177456.2(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	isoform-comment:No experimental confirmation available.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:5MPHZJq+bFnzYfBFgRSoY+GYroQ9606	intact-crc:9CA1AE9122CF5F3A|rigid:vovTUDhxYQrrH0ANZPXcgL89PaI	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:Q8TD91-2	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-10694180|ensembl:ENSP00000386566|ensembl:ENSP00000440444	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:q8td91-2(display_long)|uniprotkb:MAGEC3(gene name)|psi-mi:MAGEC3(display_short)|uniprotkb:Cancer/testis antigen 7.2(gene name synonym)|uniprotkb:HCA2(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 2(gene name synonym)|uniprotkb:MAGE-C3 antigen(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694196|imex:IM-22632-161	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	intact:EBI-10757207(isoform-parent)|ensembl:ENSG00000165509(gene)|ensembl:ENST00000409007(transcript)|ensembl:ENST00000544766(transcript)|uniprotkb:Q8TD91-2(isoform-parent)|entrezgene/locuslink:139081(identity)|refseq:NM_177456.2(identity)	-	-	isoform-comment:No experimental confirmation available.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:5MPHZJq+bFnzYfBFgRSoY+GYroQ9606	intact-crc:D299CA8DBDA1AFB8|rigid:PdcMP2YwvknsqrKoVEOeS/WVMnI	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TBZ3	uniprotkb:Q9UN19	intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0	intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602	psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym)	psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694211|imex:IM-22632-162	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1|entrezgene/locuslink:91833(identity)|refseq:NM_144574.3(identity)	refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695|entrezgene/locuslink:27071(identity)|refseq:NM_014395.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FRK (P42685), FYN (P06241), HCK (P08631), LYN (P07948), SRC (P12931), SYK (P43405), YES1 (P07947)."|comment:"The interaction failed to show if a kinase-dead version of ABL2 (P42684) was used."|figure legend:Suppl. table S3, suppl. figs. S3 and S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606	rogid:YYI49xKbndaB1MfL/QEovp2BF009606	intact-crc:E65A9B073EAD33BF|rigid:45/uOV2AqDMtDjF1OJMOxrueL00	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q06124-3	uniprotkb:Q8TBB1	intact:EBI-10694227|ensembl:ENSP00000376376	intact:EBI-739832|uniprotkb:Q4W5K7|uniprotkb:Q8N4C2|uniprotkb:Q96MJ7|uniprotkb:Q9BY20|ensembl:ENSP00000263925	psi-mi:q06124-3(display_long)|uniprotkb:PTPN11(gene name)|psi-mi:PTPN11(display_short)|uniprotkb:PTP2C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1D(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 2C(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)|uniprotkb:SH-PTP3(gene name synonym)|uniprotkb:SHPTP2(gene name synonym)	psi-mi:lnx1_human(display_long)|uniprotkb:LNX1(gene name)|psi-mi:LNX1(display_short)|uniprotkb:LNX(gene name synonym)|uniprotkb:Numb-binding protein 1(gene name synonym)|uniprotkb:Ligand of Numb-protein X 1(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 2(gene name synonym)|uniprotkb:PDZRN2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase LNX(gene name synonym)|uniprotkb:UNQ574/PRO1136(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694231|imex:IM-22632-163	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000179295(gene)|ensembl:ENST00000392597(transcript)|intact:EBI-297779(isoform-parent)|entrezgene/locuslink:5781(identity)|refseq:NM_080601.1(identity)	refseq:NP_001119800.1|refseq:NP_116011.2|refseq:XP_005265842.1|refseq:XP_016864265.1|ensembl:ENSG00000072201(gene)|ensembl:ENST00000263925(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8TBB1|rcsb pdb:3B76|rcsb pdb:5H7R|rcsb pdb:5H7S|reactome:R-HSA-983168|refseq:NM_001126328.2(identity)|entrezgene/locuslink:84708(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FES (P07332), FRK (P42685), PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:yxq9b69NsSDmdOoSrvXwZXpwK+U9606	rogid:tWvePnVxh9yxWl8nQd3KZhCSKKo9606	intact-crc:2044C9CC9B23BE40|rigid:2SXR0hk91Uj+ezVNLaAt51ca0+4	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TBB1	uniprotkb:P52333	intact:EBI-739832|uniprotkb:Q4W5K7|uniprotkb:Q8N4C2|uniprotkb:Q96MJ7|uniprotkb:Q9BY20|ensembl:ENSP00000263925	intact:EBI-518246|uniprotkb:Q13259|uniprotkb:Q13260|uniprotkb:Q13611|uniprotkb:Q9Y6S2|uniprotkb:Q99699|uniprotkb:Q8N1E8|ensembl:ENSP00000391676|ensembl:ENSP00000432511	psi-mi:lnx1_human(display_long)|uniprotkb:LNX1(gene name)|psi-mi:LNX1(display_short)|uniprotkb:LNX(gene name synonym)|uniprotkb:Numb-binding protein 1(gene name synonym)|uniprotkb:Ligand of Numb-protein X 1(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 2(gene name synonym)|uniprotkb:PDZRN2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase LNX(gene name synonym)|uniprotkb:UNQ574/PRO1136(orf name)	psi-mi:jak3_human(display_long)|uniprotkb:Janus kinase 3(gene name synonym)|uniprotkb:Leukocyte janus kinase(gene name synonym)|uniprotkb:JAK3(gene name)|psi-mi:JAK3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694246|imex:IM-22632-164	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119800.1|refseq:NP_116011.2|refseq:XP_005265842.1|refseq:XP_016864265.1|ensembl:ENSG00000072201(gene)|ensembl:ENST00000263925(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8TBB1|rcsb pdb:3B76|rcsb pdb:5H7R|rcsb pdb:5H7S|reactome:R-HSA-983168|refseq:NM_001126328.2(identity)|entrezgene/locuslink:84708(identity)	refseq:NP_000206.2|dip:DIP-274N|ensembl:ENST00000458235(transcript)|ensembl:ENST00000527670(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002731"(negative regulation of dendritic cell cytokine production)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071104"(response to interleukin-9)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019749|interpro:IPR020635|interpro:IPR020775|interpro:IPR036860|interpro:IPR041046|rcsb pdb:4HVI|rcsb pdb:4I6Q|rcsb pdb:4QPS|rcsb pdb:4QT1|rcsb pdb:4RIO|rcsb pdb:4V0G|rcsb pdb:4Z16|interpro:IPR041155|interpro:IPR041381|rcsb pdb:1YVJ|rcsb pdb:5LWM|rcsb pdb:5LWN|rcsb pdb:3LXK|rcsb pdb:3LXL|rcsb pdb:3PJC|rcsb pdb:3ZC6|rcsb pdb:3ZEP|rcsb pdb:4HVD|rcsb pdb:4HVG|rcsb pdb:4HVH|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0070232"(regulation of T cell apoptotic process)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0045087"(innate immune response)|go:"GO:0045221"(negative regulation of FasL production)|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|ensembl:ENSG00000105639(gene)|reactome:R-HSA-9020958|reactome:R-HSA-912526|reactome:R-HSA-9679191|rcsb pdb:5TOZ|rcsb pdb:5TTS|rcsb pdb:5TTU|rcsb pdb:5TTV|rcsb pdb:5VO6|rcsb pdb:5W86|rcsb pdb:5WFJ|rcsb pdb:6AAK|rcsb pdb:6DA4|rcsb pdb:6DB3|rcsb pdb:6DB4|rcsb pdb:6DUD|rcsb pdb:6GL9|rcsb pdb:6GLA|rcsb pdb:6GLB|rcsb pdb:6HZV|rcsb pdb:6NY4|rcsb pdb:7APF|rcsb pdb:7APG|rcsb pdb:7C3N|reactome:R-HSA-1266695|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|entrezgene/locuslink:3718(identity)|refseq:NM_000215.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), SYK (P43405)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:tWvePnVxh9yxWl8nQd3KZhCSKKo9606	rogid:cHXRp+Xei7sembAUQyV46ooa+P49606	intact-crc:03AD666E82E7BE69|rigid:MXKtlvpWA3HqdYqjPhEI/rBkGbQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TBB1	uniprotkb:O14544	intact:EBI-739832|uniprotkb:Q4W5K7|uniprotkb:Q8N4C2|uniprotkb:Q96MJ7|uniprotkb:Q9BY20|ensembl:ENSP00000263925	intact:EBI-3929549|uniprotkb:Q8WUM3|ensembl:ENSP00000381034|ensembl:ENSP00000463395	psi-mi:lnx1_human(display_long)|uniprotkb:LNX1(gene name)|psi-mi:LNX1(display_short)|uniprotkb:LNX(gene name synonym)|uniprotkb:Numb-binding protein 1(gene name synonym)|uniprotkb:Ligand of Numb-protein X 1(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 2(gene name synonym)|uniprotkb:PDZRN2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase LNX(gene name synonym)|uniprotkb:UNQ574/PRO1136(orf name)	psi-mi:socs6_human(display_long)|uniprotkb:SOCS6(gene name)|psi-mi:SOCS6(display_short)|uniprotkb:CIS4(gene name synonym)|uniprotkb:SOCS4(gene name synonym)|uniprotkb:Cytokine-inducible SH2 protein 4(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694276|imex:IM-22632-166	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119800.1|refseq:NP_116011.2|refseq:XP_005265842.1|refseq:XP_016864265.1|ensembl:ENSG00000072201(gene)|ensembl:ENST00000263925(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8TBB1|rcsb pdb:3B76|rcsb pdb:5H7R|rcsb pdb:5H7S|reactome:R-HSA-983168|refseq:NM_001126328.2(identity)|entrezgene/locuslink:84708(identity)	interpro:IPR037345|mint:O14544|rcsb pdb:2VIF|reactome:R-HSA-1433559|reactome:R-HSA-8951664|reactome:R-HSA-9706369|interpro:IPR036860|ensembl:ENSG00000170677(gene)|ensembl:ENST00000397942(transcript)|ensembl:ENST00000582322(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028421|interpro:IPR035865|interpro:IPR036036|refseq:NP_004223.2|refseq:XP_005266840.1|refseq:XP_016881575.1|refseq:XP_016881576.1|refseq:NM_004232.3(identity)|entrezgene/locuslink:9306(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), PTK2 (Q05397), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:tWvePnVxh9yxWl8nQd3KZhCSKKo9606	rogid:O++hp+HHhT2m2QNupHdNfK5DBqQ9606	intact-crc:4869B0F567CEBE4B|rigid:sYlGSqRZXHeSTvEdLNLxwGtpSbI	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:Q8TBB1	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-739832|uniprotkb:Q4W5K7|uniprotkb:Q8N4C2|uniprotkb:Q96MJ7|uniprotkb:Q9BY20|ensembl:ENSP00000263925	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:lnx1_human(display_long)|uniprotkb:LNX1(gene name)|psi-mi:LNX1(display_short)|uniprotkb:LNX(gene name synonym)|uniprotkb:Numb-binding protein 1(gene name synonym)|uniprotkb:Ligand of Numb-protein X 1(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 2(gene name synonym)|uniprotkb:PDZRN2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase LNX(gene name synonym)|uniprotkb:UNQ574/PRO1136(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694261|imex:IM-22632-165	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	refseq:NP_001119800.1|refseq:NP_116011.2|refseq:XP_005265842.1|refseq:XP_016864265.1|ensembl:ENSG00000072201(gene)|ensembl:ENST00000263925(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8TBB1|rcsb pdb:3B76|rcsb pdb:5H7R|rcsb pdb:5H7S|reactome:R-HSA-983168|refseq:NM_001126328.2(identity)|entrezgene/locuslink:84708(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:tWvePnVxh9yxWl8nQd3KZhCSKKo9606	intact-crc:120B38973BDB3C28|rigid:WXVPQEYlTE2GWxAdAQu+5JJhrlQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5R372-2	uniprotkb:Q8TAL5	intact:EBI-10692254|ensembl:ENSP00000350027	intact:EBI-10694291|ensembl:ENSP00000288462|ensembl:ENSP00000363280	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:ci043_human(display_long)|uniprotkb:C9orf43(gene name)|psi-mi:C9orf43(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694295|imex:IM-22632-167	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	refseq:NP_001265558.1|refseq:NP_689999.1|ensembl:ENSG00000157653(gene)|ensembl:ENST00000288462(transcript)|ensembl:ENST00000374165(transcript)|interpro:IPR029134|mint:Q8TAL5|refseq:NM_001278629.1(identity)|entrezgene/locuslink:257169(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FES (P07332)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	rogid:LGnLEmC1sPfnq+qr2b3M7cEccek9606	intact-crc:3EB10B62CFE3A994|rigid:eJUhhZkMvQnZauEbWk6gp5iT7IQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TAK5	uniprotkb:P46108-2	intact:EBI-8468945|intact:MINT-6778891|uniprotkb:D3DV14|uniprotkb:B1AVJ8|uniprotkb:Q8NAR5|ensembl:ENSP00000357914	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:gabp2_human(display_long)|uniprotkb:GABPB2(gene name)|psi-mi:GABPB2(display_short)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694310|imex:IM-22632-168	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001310837.1|refseq:NP_653219.1|refseq:XP_016855738.1|ensembl:ENSG00000143458(gene)|ensembl:ENST00000368918(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q8TAK5|entrezgene/locuslink:126626(identity)|refseq:NM_144618.2(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	function:"May function as transcription factor capable of interacting with purine rich repeats (GA repeats)"|comment:mint|comment:homomint	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:F1UTCglE16qDpbAHMtdpL/zq8XY9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:D827275FDABBE4ED|rigid:TnyDeFCpUaCQeJ4FJm467bvWFwI	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEC7	uniprotkb:P40763-2	intact:EBI-8469616|intact:MINT-6779113|uniprotkb:Q9H8S3|uniprotkb:A8MVD3|uniprotkb:A8K8J0|uniprotkb:H9KV97|ensembl:ENSP00000353695|ensembl:ENSP00000378216|ensembl:ENSP00000422354	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:gstcd_human(display_long)|uniprotkb:GSTCD(gene name)|psi-mi:GSTCD(display_short)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694325|imex:IM-22632-169	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530550.1|refseq:XP_011530551.1|refseq:XP_011530554.1|refseq:NP_001026890.2|refseq:NP_079027.2|refseq:XP_005263279.1|ensembl:ENSG00000138780(gene)|ensembl:ENST00000360505(transcript)|ensembl:ENST00000394728(transcript)|ensembl:ENST00000515279(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR025714|interpro:IPR029063|interpro:IPR036282|mint:Q8NEC7|entrezgene/locuslink:79807(identity)|refseq:NM_001031720.3(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	comment:mint|comment:homomint	isoform-comment:Contains a phosphotyrosine at position 704.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:jg34D624i8iGCgGTedM+tfGgmRQ9606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:864E836CF7E69EE8|rigid:mPsQpbEB1f2iYc016YDBHQO5ZM4	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEC7	uniprotkb:Q9UN19	intact:EBI-8469616|intact:MINT-6779113|uniprotkb:Q9H8S3|uniprotkb:A8MVD3|uniprotkb:A8K8J0|uniprotkb:H9KV97|ensembl:ENSP00000353695|ensembl:ENSP00000378216|ensembl:ENSP00000422354	intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602	psi-mi:gstcd_human(display_long)|uniprotkb:GSTCD(gene name)|psi-mi:GSTCD(display_short)	psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694355|imex:IM-22632-171	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530550.1|refseq:XP_011530551.1|refseq:XP_011530554.1|refseq:NP_001026890.2|refseq:NP_079027.2|refseq:XP_005263279.1|ensembl:ENSG00000138780(gene)|ensembl:ENST00000360505(transcript)|ensembl:ENST00000394728(transcript)|ensembl:ENST00000515279(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR025714|interpro:IPR029063|interpro:IPR036282|mint:Q8NEC7|entrezgene/locuslink:79807(identity)|refseq:NM_001031720.3(identity)	refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695|entrezgene/locuslink:27071(identity)|refseq:NM_014395.2(identity)	-	comment:mint|comment:homomint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:jg34D624i8iGCgGTedM+tfGgmRQ9606	rogid:YYI49xKbndaB1MfL/QEovp2BF009606	intact-crc:CB1E36CCFC6ABEE0|rigid:GL8qLK2JpbW+QJRfYnJ+dUsCKrA	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEC7	uniprotkb:P40763	intact:EBI-8469616|intact:MINT-6779113|uniprotkb:Q9H8S3|uniprotkb:A8MVD3|uniprotkb:A8K8J0|uniprotkb:H9KV97|ensembl:ENSP00000353695|ensembl:ENSP00000378216|ensembl:ENSP00000422354	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:gstcd_human(display_long)|uniprotkb:GSTCD(gene name)|psi-mi:GSTCD(display_short)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694340|imex:IM-22632-170	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530550.1|refseq:XP_011530551.1|refseq:XP_011530554.1|refseq:NP_001026890.2|refseq:NP_079027.2|refseq:XP_005263279.1|ensembl:ENSG00000138780(gene)|ensembl:ENST00000360505(transcript)|ensembl:ENST00000394728(transcript)|ensembl:ENST00000515279(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR025714|interpro:IPR029063|interpro:IPR036282|mint:Q8NEC7|entrezgene/locuslink:79807(identity)|refseq:NM_001031720.3(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	comment:mint|comment:homomint	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:jg34D624i8iGCgGTedM+tfGgmRQ9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:17A0270FDA85E1AF|rigid:DSmBtS7elbJriLfoaugM8NC3/rY	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:Q8NBZ0	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-769401|uniprotkb:Q6Y2K3|intact:EBI-28973946|ensembl:ENSP00000457016	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:in80e_human(display_long)|uniprotkb:CCDC95(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 95(gene name synonym)|uniprotkb:INO80E(gene name)|psi-mi:INO80E(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694385|imex:IM-22632-173	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	refseq:NP_775889.1|ensembl:ENST00000562441|ensembl:ENSP00000456073|ensembl:ENSP00000457016|ensembl:ENST00000567065|ensembl:ENSP00000454665|ensembl:ENST00000620599|ensembl:ENSP00000484187|refseq:NP_001291491.1|refseq:NP_001291492.1|ensembl:ENSG00000169592(gene)|ensembl:ENST00000563197(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0031011"(Ino80 complex)|interpro:IPR026678|mint:Q8NBZ0|reactome:R-HSA-5689603|reactome:R-HSA-5696394|refseq:NM_173618.1(identity)|entrezgene/locuslink:283899(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:gGBXpYQkxY5mcF4I/4rTzjXZbG09606	intact-crc:A25EDD9CE892870D|rigid:ZwG5jk9RbuQYwPghTvOdp70W8RI	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q8NEA6	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-744456|uniprotkb:B1AL19|uniprotkb:Q1PHK5|ensembl:ENSP00000325494|ensembl:ENSP00000507306	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:glis3_human(display_long)|uniprotkb:GLI-similar 3(gene name synonym)|uniprotkb:Zinc finger protein 515(gene name synonym)|uniprotkb:GLIS3(gene name)|psi-mi:GLIS3(display_short)|uniprotkb:ZNF515(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694370|imex:IM-22632-172	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	refseq:NP_001035878.1|refseq:NP_689842.3|refseq:XP_011516065.1|refseq:XP_011516066.1|refseq:XP_011516068.1|ensembl:ENSP00000325494|ensembl:ENST00000381971|ensembl:ENSP00000371398|ensembl:ENSP00000507306|refseq:XP_005251443.1|ensembl:ENSG00000107249(gene)|ensembl:ENST00000324333(transcript)|ensembl:ENST00000682749(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030405|interpro:IPR036236|interpro:IPR043359|mint:Q8NEA6|refseq:XP_016869850.1|entrezgene/locuslink:169792(identity)|refseq:NM_152629.3(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:Lw/ndmcKfz+wO+0eEheRj4Y0fXM9606	intact-crc:7AE05FC3227CA957|rigid:yBlDubrY5sRWHXtbBC/jyec5wDM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NA54	uniprotkb:Q92569	intact:EBI-10220600|ensembl:ENSP00000324882|ensembl:ENSP00000417769|uniprotkb:Q49AL6|uniprotkb:A4D0X0|uniprotkb:Q8N9Y2|uniprotkb:Q5BJD9|uniprotkb:Q4G189|uniprotkb:Q6NUH6	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:iqub_human(display_long)|uniprotkb:IQUB(gene name)|psi-mi:IQUB(display_short)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694415|imex:IM-22632-175	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164675(gene)|ensembl:ENST00000324698(transcript)|ensembl:ENST00000466202(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0060271"(cilium assembly)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR037695|rcsb pdb:2DAF|refseq:XP_016867260.1|refseq:NP_001269784.1|refseq:NP_849149.3|refseq:XP_005250218.1|refseq:NP_001308222.1|refseq:XP_011514135.1|refseq:XP_011514136.1|refseq:XM_005250162.2(identity)|entrezgene/locuslink:154865(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DyNYrJx7MGhPYi/ba2kD4o+O/J49606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:5FC6157D600A8363|rigid:FEJ7LzZPUJDTPCXUBazzXrkL0Pc	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:Q8NBB4	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-5292994|uniprotkb:Q3B798|uniprotkb:Q6WLH8|uniprotkb:Q86WS8|ensembl:ENSP00000282326	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:zsca1_human(display_long)|uniprotkb:ZSCAN1(gene name)|psi-mi:ZSCAN1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694400|imex:IM-22632-174	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	refseq:NP_872378.3|ensembl:ENSG00000152467(gene)|ensembl:ENST00000282326(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR038269|refseq:NM_182572.3(identity)|entrezgene/locuslink:284312(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:WR2G0UBcX3kvOdwdBzRYAEmtJs09606	intact-crc:8CF5BDB17441B691|rigid:hwJplR7pG7yCcy7J3GHFoT3DfjQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N7B6-2	uniprotkb:P62993	intact:EBI-10694433|ensembl:ENSP00000295290|ensembl:ENSP00000354171|ensembl:ENSP00000423477|ensembl:ENSP00000423536|ensembl:ENSP00000425938	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:q8n7b6-2(display_long)|uniprotkb:PACRGL(gene name)|psi-mi:PACRGL(display_short)|uniprotkb:C4orf28(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694430|imex:IM-22632-176	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163138(gene)|ensembl:ENST00000295290(transcript)|ensembl:ENST00000360916(transcript)|ensembl:ENST00000467997(transcript)|ensembl:ENST00000506702(transcript)|ensembl:ENST00000507634(transcript)|intact:EBI-3925298(isoform-parent)|uniprotkb:Q8N7B6-2(isoform-parent)|entrezgene/locuslink:133015(identity)|refseq:NM_145048.3(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ggQEVTS6If4Zi1nkqpe4Lg/Ages9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:1D407E77DE0809AD|rigid:D+pHjLy4yZv3SzSbWWPoPv32Qrs	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N6T3-3	uniprotkb:Q5R372-2	intact:EBI-10694449|ensembl:ENSP00000359298	intact:EBI-10692254|ensembl:ENSP00000350027	psi-mi:q8n6t3-3(display_long)|uniprotkb:ARFGAP1(gene name)|psi-mi:ARFGAP1(display_short)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)|uniprotkb:ARF1GAP(gene name synonym)	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694453|imex:IM-22632-177	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-716933(isoform-parent)|ensembl:ENSG00000101199(gene)|ensembl:ENST00000370275(transcript)|uniprotkb:Q8N6T3-3(isoform-parent)|refseq:NM_001281482.1(identity)|entrezgene/locuslink:55738(identity)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:A38kI1kCOsmDVgNQTMQoGNKwOrs9606	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	intact-crc:39C8E74829F3B09B|rigid:Kp+s0sSa1dHcrABVM7jk//yEykQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N6F8	uniprotkb:Q92569	intact:EBI-8487781|intact:MINT-8417729|ensembl:ENSP00000297873	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:met27_human(display_long)|uniprotkb:METTL27(gene name)|psi-mi:METTL27(display_short)|uniprotkb:WBSCR27(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 27 protein(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694468|imex:IM-22632-178	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_689772.2|ensembl:ENSG00000165171(gene)|ensembl:ENST00000297873(transcript)|go:"GO:0008168"(methyltransferase activity)|interpro:IPR029063|interpro:IPR041698|mint:Q8N6F8|refseq:NM_152559.2(identity)|entrezgene/locuslink:155368(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	comment:mint|comment:homomint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:T+4JBqFxUvWNzHLf1bT6SGLCaJs9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:8FA6300E9C672D7D|rigid:i8+QJHaDs3uOblDGVBIEw3h7VDw	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N5V2	uniprotkb:P08631-2	intact:EBI-718372|uniprotkb:B9A045|uniprotkb:Q53QQ4|uniprotkb:Q53ST7|uniprotkb:Q6GMQ5|uniprotkb:Q9NQD6|uniprotkb:B4DMB8|uniprotkb:E9PC42|ensembl:ENSP00000264051	intact:EBI-9834454|ensembl:ENSP00000429848|ensembl:ENSP00000486627	psi-mi:ngef_human(display_long)|uniprotkb:Eph-interacting exchange protein(gene name synonym)|uniprotkb:Neuronal guanine nucleotide exchange factor(gene name synonym)|uniprotkb:NGEF(gene name)|psi-mi:NGEF(display_short)	psi-mi:p08631-2(display_long)|uniprotkb:p59-HCK(isoform synonym)|uniprotkb:p59Hck(isoform synonym)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694483|imex:IM-22632-179	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107562.1|refseq:NP_062824.2|refseq:XP_011509225.1|ensembl:ENSG00000066248(gene)|ensembl:ENST00000264051(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030426"(growth cone)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035635|interpro:IPR035899|interpro:IPR036028|mint:Q8N5V2|reactome:R-HSA-193648|reactome:R-HSA-3928663|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|go:"GO:0005829"(cytosol)|entrezgene/locuslink:25791(identity)|refseq:NM_019850.2(identity)	uniprotkb:P08631-2(isoform-parent)|intact:EBI-346340(isoform-parent)|ensembl:ENSG00000101336(gene)|ensembl:ENST00000520553(transcript)|ensembl:ENST00000629881(transcript)|entrezgene/locuslink:3055(identity)|refseq:NM_001172129.1(identity)	-	-	isoform-comment:Initiator Met-1 is removed. Contains a N-myristoyl glycine at position 2. Contains a S-palmitoyl cysteine at position 3.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oAu+8njDslYpqxQaq85zzC3hb209606	rogid:qSgfntp+jqdyi7qsc7u7UA7ylO09606	intact-crc:B8CA9C6810F43A2E|rigid:c4kGJsbqoHwnyhenYr8kDMfU2AI	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N485	uniprotkb:Q8NEU8	intact:EBI-10694501|uniprotkb:Q8N7I2|uniprotkb:A8K4R9|ensembl:ENSP00000274382	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	psi-mi:lix1_human(display_long)|uniprotkb:LIX1(gene name)|psi-mi:LIX1(display_short)|uniprotkb:C5orf11(gene name synonym)	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694498|imex:IM-22632-180	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694966.3|ensembl:ENSG00000145721(gene)|ensembl:ENST00000274382(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR029270|refseq:NM_153234.4(identity)|entrezgene/locuslink:167410(identity)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:l+3u4U0RlFJKO3tqAsJ0fLKqzoo9606	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	intact-crc:B93EDEDC9E091D70|rigid:sgjKaX7Imn5yS93f1aeq0w6YCDE	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N2H9	uniprotkb:Q92569	intact:EBI-448457|uniprotkb:Q8N3E1|uniprotkb:Q8N9Q6|uniprotkb:Q8TAW7|uniprotkb:Q8TED5|ensembl:ENSP00000322532	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:peli3_human(display_long)|uniprotkb:PELI3(gene name)|psi-mi:PELI3(display_short)|uniprotkb:RING-type E3 ubiquitin transferase pellino homolog 3(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694534|imex:IM-22632-182	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001091980.1|refseq:NP_001230064.1|refseq:NP_659502.2|refseq:NP_001230065.1|refseq:XP_011543186.1|refseq:XP_016872954.1|dip:DIP-31770N|ensembl:ENSG00000174516(gene)|ensembl:ENST00000320740(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008592"(regulation of Toll signaling pathway)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR006800(Pellino)|mint:Q8N2H9|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-975144|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|entrezgene/locuslink:246330(identity)|refseq:NM_145065.2(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rj8IvjYfW2mL1sK2/f6O2cinMNo9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:0D0B95C01D3965DC|rigid:a80TH7qq+xv4XUWoZnk/icRsUqQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N3R9	uniprotkb:Q8WXH5	intact:EBI-2513978|ensembl:ENSP00000261681|ensembl:ENSP00000503321|ensembl:ENSP00000503322|ensembl:ENSP00000503517|ensembl:ENSP00000503713|uniprotkb:Q86T98|uniprotkb:Q8N7I5|uniprotkb:Q7Z631|uniprotkb:Q9H9Q0|uniprotkb:A1L380	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	psi-mi:pals1_human(display_long)|uniprotkb:PALS1(gene name)|psi-mi:PALS1(display_short)|uniprotkb:MAGUK p55 subfamily member 5(gene name synonym)|uniprotkb:MPP5(gene name synonym)|uniprotkb:Membrane protein, palmitoylated 5(gene name synonym)|uniprotkb:Protein associated with Lin-7 1(gene name synonym)	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694519|imex:IM-22632-181	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0010467"(gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032288"(myelin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035750"(protein localization to myelin sheath abaxonal region)|go:"GO:0043204"(perikaryon)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR015145(L27-N)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035601|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q8N3R9|rcsb pdb:1Y76|rcsb pdb:3UIT|rcsb pdb:4UU5|rcsb pdb:4UU6|rcsb pdb:4WSI|rcsb pdb:7M4R|rcsb pdb:7NTJ|rcsb pdb:7NTK|reactome:R-HSA-420029|ensembl:ENSG00000072415(gene)|ensembl:ENST00000261681(transcript)|ensembl:ENST00000676464(transcript)|ensembl:ENST00000677382(transcript)|ensembl:ENST00000677835(transcript)|ensembl:ENST00000678380(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|refseq:XP_011535388.1|refseq:XP_011535389.1|refseq:NP_071919.2|refseq:NP_001243479.1|refseq:XP_005268060.1|entrezgene/locuslink:64398(identity)|refseq:NM_022474.3(identity)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FES (P07332), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:VpQVKlVcuBSs8mztUd9iHqkIXDM9606	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	intact-crc:F189E938DDB33924|rigid:pNjH73foh7G3nEflveG9b9d+keE	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZS5	uniprotkb:P46108-2	intact:EBI-8477661|intact:MINT-8417707|uniprotkb:Q8IZS3|uniprotkb:Q8IZR9|uniprotkb:Q7Z2X5|uniprotkb:Q8IUL6|uniprotkb:Q8IZS1|uniprotkb:Q8IUM1	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:ofcc1_human(display_long)|uniprotkb:OFCC1(gene name)|psi-mi:OFCC1(display_short)|uniprotkb:MRDS1(gene name synonym)|uniprotkb:Orofacial clefting chromosomal breakpoint region candidate 1 protein(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694549|imex:IM-22632-183	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR031390|mint:Q8IZS5|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:XM_003118558.3(identity)|entrezgene/locuslink:266553(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	comment:mint|comment:homomint	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:4cDMDdOlk+3FSJ96g5F+dQ5dIJw9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:1236BBB951739B24|rigid:rj52/3zjxL697AhAoaoBVC2xt2o	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q8IXS0	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-10694567|uniprotkb:Q5JYK1|ensembl:ENSP00000274673	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:f217a_human(display_long)|uniprotkb:FAM217A(gene name)|psi-mi:FAM217A(display_short)|uniprotkb:C6orf146(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694564|imex:IM-22632-184	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	refseq:NP_775834.2|ensembl:ENSG00000145975(gene)|ensembl:ENST00000274673(transcript)|interpro:IPR029266|entrezgene/locuslink:222826(identity)|refseq:NM_173563.2(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:i3Q9Q5yfPqGDHqLSl7386JGPO989606	intact-crc:8BBCCE94CE790B19|rigid:Zx8dGOJxsJFOsfBn+GjqQhNFqGw	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q86UA6-6	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-10691610|ensembl:ENSP00000439939	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:q86ua6-6(display_long)|uniprotkb:RPAIN(gene name)|psi-mi:RPAIN(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Delta3(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694606|imex:IM-22632-186	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	intact:EBI-3907663(isoform-parent)|ensembl:ENSG00000129197(gene)|ensembl:ENST00000536255(transcript)|refseq:NM_001160246.1(identity)|entrezgene/locuslink:84268(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2018/04/06	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:O1pqZEoKwTB9kuzAQJM5x81s9z09606	intact-crc:37E633BB6C94E76C|rigid:E2RliB9b8z6O2Ftx0LItjt/eqAc	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:Q86WK9	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-10694587|uniprotkb:Q86VE4|uniprotkb:A2A2D3|uniprotkb:Q5XKF9|ensembl:ENSP00000363414|ensembl:ENSP00000502514	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:paqr7_human(display_long)|uniprotkb:Membrane progesterone P4 receptor alpha(gene name synonym)|uniprotkb:Membrane progesterone receptor alpha(gene name synonym)|uniprotkb:Progesterone and adipoQ receptor family member 7(gene name synonym)|uniprotkb:PAQR7(gene name)|psi-mi:PAQR7(display_short)|uniprotkb:MRPA(gene name synonym)|uniprotkb:Progestin and adipoQ receptor family member 7(gene name synonym)|uniprotkb:Progestin and adipoQ receptor family member VII(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694584|imex:IM-22632-185	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_848509.1|refseq:XP_005245802.1|refseq:XP_005245803.1|refseq:XP_011539163.1|refseq:XP_011539164.1|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0048477"(oogenesis)|go:"GO:0048545"(response to steroid hormone)|interpro:IPR004254(Hly-III related)|ensembl:ENSG00000182749(gene)|ensembl:ENST00000374296(transcript)|ensembl:ENST00000675840(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|entrezgene/locuslink:164091(identity)|refseq:NM_178422.5(identity)	-	crc64:6C00632211C8012D	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:NR1qCNOh+qu4PyZ+cLiJX9RTmvE9606	intact-crc:C4E9EA42173B3B75|rigid:F2J31OsR6Hm2Vqk1DTFNtwQMI8s	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z417	uniprotkb:P46108-2	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694636|imex:IM-22632-188	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417|entrezgene/locuslink:57532(identity)|refseq:NM_020772.2(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:A372DCF3DB3A0287|rigid:/wMZ2ZkhAS7NfHMscfAQA5O1wtY	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z417	uniprotkb:P40763-2	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694621|imex:IM-22632-187	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417|entrezgene/locuslink:57532(identity)|refseq:NM_020772.2(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	-	isoform-comment:Contains a phosphotyrosine at position 704.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:E5D98DCB68ED74AB|rigid:ST+pt1NdIQw+0SkQgQd2eLdQtCY	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TEW6	uniprotkb:Q7L591-3	intact:EBI-6918542|ensembl:ENSP00000344277|ensembl:ENSP00000455128|uniprotkb:O75209|uniprotkb:Q9BTP2|uniprotkb:Q9NVV3	intact:EBI-10694655|ensembl:ENSP00000325174	psi-mi:dok4_human(display_long)|uniprotkb:DOK4(gene name)|psi-mi:DOK4(display_short)|uniprotkb:Downstream of tyrosine kinase 4(gene name synonym)|uniprotkb:Insulin receptor substrate 5(gene name synonym)	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694651|imex:IM-22632-189	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000125170(gene)|ensembl:ENST00000340099(transcript)|ensembl:ENST00000569548(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0043410"(positive regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_060580.2|refseq:XP_005256100.1|entrezgene/locuslink:55715(identity)|refseq:NM_018110.3(identity)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	-	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), SYK (P43405), YES1 (P07947)."|comment:"The interaction failed to show if kinase-dead versions of ABL2 (P42684) or FYN (P06241) were used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Xc4aPsHtdQKj02Q5cqqgw29pSS09606	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	intact-crc:4A9F4D952E9B16E0|rigid:VUiYbDs/JrSzUQfDOdHbLd3vMyw	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763-2	uniprotkb:Q7L591-3	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	intact:EBI-10694655|ensembl:ENSP00000325174	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694671|imex:IM-22632-190	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	-	isoform-comment:Contains a phosphotyrosine at position 704.	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	intact-crc:D9C33E5DA78B86D7|rigid:q/5uXD/qP56EGmXrKrY9mfqWS90	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:Q7L591-3	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-10694655|ensembl:ENSP00000325174	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694686|imex:IM-22632-191	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	-	crc64:6C00632211C8012D	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	intact-crc:C6C8E8A7592583A6|rigid:ArWdpcDWTCIQNaXJ9/DzNQFB8vw	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q7L591-3	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-10694655|ensembl:ENSP00000325174	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694701|imex:IM-22632-192	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	intact-crc:E1880DB6F936C90A|rigid:qB1AeYj64SqTd75NWEsFISg6HF0	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7L591-3	uniprotkb:P46108	intact:EBI-10694655|ensembl:ENSP00000325174	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694716|imex:IM-22632-193	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:AA5CC2E0DFB6C8EC|rigid:gDluw/pMUSTDuPy6NyJFOL7538I	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7L591-3	uniprotkb:O60496	intact:EBI-10694655|ensembl:ENSP00000325174	intact:EBI-1046024|uniprotkb:Q8N5A4|ensembl:ENSP00000276420	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:dok2_human(display_long)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:DOK2(gene name)|psi-mi:DOK2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694746|imex:IM-22632-195	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	refseq:NP_003965.2|ensembl:ENSG00000147443(gene)|ensembl:ENST00000276420(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|rcsb pdb:2D9W|rcsb pdb:2DLW|reactome:R-HSA-210993|reactome:R-HSA-8853659|go:"GO:0007166"(cell surface receptor signaling pathway)|entrezgene/locuslink:9046(identity)|refseq:NM_003974.2(identity)	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	rogid:gBEpjlq3kc6oYF0uVqPz04hfrHw9606	intact-crc:3A95945ECFECBC85|rigid:r3ULyM8s5p+wI0BvVlurOy9GIKg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99704	uniprotkb:Q7L591-3	intact:EBI-1384360|uniprotkb:O43204|uniprotkb:Q53TY2|uniprotkb:Q9UHG6|ensembl:ENSP00000233668	intact:EBI-10694655|ensembl:ENSP00000325174	psi-mi:dok1_human(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:pp62(gene name synonym)|uniprotkb:DOK1(gene name)|psi-mi:DOK1(display_short)	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694731|imex:IM-22632-194	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001184189.1|refseq:NP_001372.1|refseq:NP_001305797.1|ensembl:ENSG00000115325(gene)|ensembl:ENST00000233668(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:Q99704|rcsb pdb:2V76|reactome:R-HSA-8849469|reactome:R-HSA-8853659|refseq:NM_001381.3(identity)|entrezgene/locuslink:1796(identity)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	-	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Pvjez+wIa3gWdY9ZYvWN6lmOM4o9606	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	intact-crc:F4B8E949D968D01E|rigid:W6uSydVrqZuMHlPUfXjuH/8Lb6E	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7L591-3	uniprotkb:Q9UKG1	intact:EBI-10694655|ensembl:ENSP00000325174	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694776|imex:IM-22632-197	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:6E55109D8D384436|rigid:X4itx5kKv6mopcG0Dv+czzH7oAM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5VZ18	uniprotkb:Q7L591-3	intact:EBI-3956977|uniprotkb:Q8TEQ5|ensembl:ENSP00000307369	intact:EBI-10694655|ensembl:ENSP00000325174	psi-mi:she_human(display_long)|uniprotkb:SHE(gene name)|psi-mi:SHE(display_short)	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694761|imex:IM-22632-196	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011507465.1|refseq:NP_001010846.1|ensembl:ENSG00000169291(gene)|ensembl:ENST00000304760(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|interpro:IPR000980(SH2 motif)|interpro:IPR035041|interpro:IPR035042|interpro:IPR036860|entrezgene/locuslink:126669(identity)|refseq:NM_001010846.2(identity)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	-	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ZN2ORmTe7ETaKpdPvYPJP3yQKbI9606	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	intact-crc:091D178D1727148B|rigid:W6BSb2ABqT7jK74A3/KflHd3mrc	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7L591-3	uniprotkb:Q9P104-2	intact:EBI-10694655|ensembl:ENSP00000325174	intact:EBI-10692909|ensembl:ENSP00000379270	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:q9p104-2(display_long)|uniprotkb:DOK5(gene name)|psi-mi:DOK5(display_short)|uniprotkb:C20orf180(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 5(gene name synonym)|uniprotkb:Insulin receptor substrate 6(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694791|imex:IM-22632-198	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	ensembl:ENSG00000101134(gene)|ensembl:ENST00000395939(transcript)|intact:EBI-739600(isoform-parent)|uniprotkb:Q9P104-2(isoform-parent)|refseq:NM_177959.2(identity)|entrezgene/locuslink:55816(identity)	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	isoform-comment:No experimental confirmation available.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	rogid:8p18JpE/uszPiQyb4FtcEu5QiOc9606	intact-crc:A12A7A74E2D3862F|rigid:aihE6IkdGbQDmizsxslwErGnhGI	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZMI0	uniprotkb:Q9NP31	intact:EBI-5235703|uniprotkb:B7ZKY5|uniprotkb:Q2TA78|uniprotkb:Q6ZMI6|uniprotkb:Q8IW83|uniprotkb:Q8J029|uniprotkb:Q96ES8|uniprotkb:B7ZKY7|uniprotkb:E1B6W7|ensembl:ENSP00000294952	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:ppr21_human(display_long)|uniprotkb:PPP1R21(gene name)|psi-mi:PPP1R21(display_short)|uniprotkb:CCDC128(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 128(gene name synonym)|uniprotkb:KLRAQ motif-containing protein 1(gene name synonym)|uniprotkb:KLRAQ1(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694806|imex:IM-22632-199	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129101.1|refseq:NP_001180404.1|refseq:NP_694539.1|ensembl:ENSG00000162869(gene)|ensembl:ENST00000294952(transcript)|go:"GO:0005769"(early endosome)|go:"GO:0016020"(membrane)|interpro:IPR019343|interpro:IPR019348|interpro:IPR040024|entrezgene/locuslink:129285(identity)|refseq:NM_001193475.1(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:cp4v9NF+YVUYq0eABVb/gj0TeJA9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:D8EA68DB3552DB3F|rigid:lv29AE/OtNJ2bhXo9ASGwkWjpJg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6GQQ9	uniprotkb:Q92569	intact:EBI-527784|uniprotkb:Q8WWA7|uniprotkb:Q9NQ53|uniprotkb:Q9UFF4|uniprotkb:Q5SZ60|ensembl:ENSP00000462729|uniprotkb:D3DUZ8|uniprotkb:B7Z643	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:otu7b_human(display_long)|uniprotkb:Zinc finger protein Cezanne(gene name synonym)|uniprotkb:Zinc finger A20 domain-containing protein 1(gene name synonym)|uniprotkb:Cellular zinc finger anti-NF-kappa-B protein(gene name synonym)|uniprotkb:OTUD7B(gene name)|psi-mi:OTUD7B(display_short)|uniprotkb:ZA20D1(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694840|imex:IM-22632-201	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-33805N|ensembl:ENSG00000264522(gene)|ensembl:ENST00000581312(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003323(Ovarian tumour, otubain)|rcsb pdb:5LRU|rcsb pdb:5LRV|rcsb pdb:5LRW|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689896|ensembl:ENSP00000462729|refseq:NP_064590.2|refseq:NM_020205.3(identity)|entrezgene/locuslink:56957(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:JZKj6CpuUOQ3aqvmg3YC9OnivGM9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:1667A5BAA059B46C|rigid:n61cEsKi8pHx3kMuj8eQZIsQ3vw	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6P1J6-2	uniprotkb:Q92569	intact:EBI-10694821	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:q6p1j6-2(display_long)|uniprotkb:PLB1(gene name)|psi-mi:PLB1(display_short)|uniprotkb:PLB(gene name synonym)|uniprotkb:Phospholipase B/lipase(gene name synonym)|uniprotkb:Lysophospholipase(gene name synonym)|uniprotkb:Phospholipase A2(gene name synonym)|uniprotkb:Triacylglycerol lipase(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694825|imex:IM-22632-200	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-10757275(isoform-parent)|uniprotkb:Q6P1J6-2(isoform-parent)|refseq:NM_153021.4(identity)|entrezgene/locuslink:151056(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FYN (P06241), JAK2 (O60674), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:WLweRT1dlb70eDlX6qsoWBzXA6c9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:D8B2D7FD7B17BBA2|rigid:tYRSWsXsHC6ynRtdQUyUGqsCBHg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q68G74	uniprotkb:P16885	intact:EBI-8474075|intact:MINT-8417689|uniprotkb:E9PGE3|ensembl:ENSP00000294638	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	psi-mi:lhx8_human(display_long)|uniprotkb:LHX8(gene name)|psi-mi:LHX8(display_short)	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694855|imex:IM-22632-202	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001243043.1|refseq:NP_001001933.1|ensembl:ENSG00000162624(gene)|ensembl:ENST00000294638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001674"(female germ cell nucleus)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007611"(learning or memory)|go:"GO:0008585"(female gonad development)|go:"GO:0021884"(forebrain neuron development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q68G74|entrezgene/locuslink:431707(identity)|refseq:NM_001001933.1(identity)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	-	comment:mint|comment:homomint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813), FRK (P42685), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:L7W2mSN0r9Fl/94L/D2dL5mGHz89606	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	intact-crc:10C1CDA8858FF0A0|rigid:kZu5qBQlrUEZ9yUK/Uy94lItsF0	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5VU92	uniprotkb:Q9NP31	intact:EBI-10694873|uniprotkb:Q8IYK3|ensembl:ENSP00000360167	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:dc121_human(display_long)|uniprotkb:DCAF12L1(gene name)|psi-mi:DCAF12L1(display_short)|uniprotkb:WD repeat-containing protein 40B(gene name synonym)|uniprotkb:WDR40B(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694870|imex:IM-22632-203	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_848565.2|ensembl:ENSG00000198889(gene)|ensembl:ENST00000371126(transcript)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|entrezgene/locuslink:139170(identity)|refseq:NM_178470.4(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:n9k7CP2cQy1nTJU2wnezEdfYARk9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:89C7E5EDD981854B|rigid:ghSVX+bUay7Dm61mUSviSIv68hg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q5H9J7	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-10243741|uniprotkb:Q56A74|uniprotkb:Q569J0|ensembl:ENSP00000328030|ensembl:ENSP00000446054	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:bex5_human(display_long)|uniprotkb:BEX5(gene name)|psi-mi:BEX5(display_short)|uniprotkb:Brain-expressed X-linked protein 5(gene name synonym)|uniprotkb:NADE2(gene name synonym)|uniprotkb:NGFRAP1-like protein 1(gene name synonym)|uniprotkb:NGFRAP1L1(gene name synonym)|uniprotkb:Nerve growth factor receptor-associated protein 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694890|imex:IM-22632-204	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_001012996.1|refseq:NP_001153032.1|ensembl:ENSG00000184515(gene)|ensembl:ENST00000333643(transcript)|ensembl:ENST00000543160(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR007623(Brain expressed X-linked like protein)|interpro:IPR021156|refseq:NM_001012978.2(identity)|entrezgene/locuslink:340542(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:Yx5JQ84k1eJVM/Sc9wQX/OMgtRI9606	intact-crc:AA32A8D6B2E67D3C|rigid:WeRQAzn23EP1kZp67ifPnHbI7bQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q5BJH2-2	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-10694905|ensembl:ENSP00000254742	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:q5bjh2-2(display_long)|uniprotkb:TMEM128(gene name)|psi-mi:TMEM128(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694909|imex:IM-22632-205	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	intact:EBI-10243515(isoform-parent)|ensembl:ENSG00000132406(gene)|ensembl:ENST00000254742(transcript)|uniprotkb:Q5BJH2-2(isoform-parent)|refseq:NM_032927.3(identity)|entrezgene/locuslink:85013(identity)	-	-	isoform-comment:No experimental confirmation available.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FYN (P06241), SYK (P43405)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:fsGbysnORUH/y9LqInPSyP55P4k9606	intact-crc:DD12B4A00F56E7BF|rigid:klLT6M6ns3E3y4A943lKESsyWbg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:Q5BJH2-2	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-10694905|ensembl:ENSP00000254742	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:q5bjh2-2(display_long)|uniprotkb:TMEM128(gene name)|psi-mi:TMEM128(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694924|imex:IM-22632-206	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	intact:EBI-10243515(isoform-parent)|ensembl:ENSG00000132406(gene)|ensembl:ENST00000254742(transcript)|uniprotkb:Q5BJH2-2(isoform-parent)|refseq:NM_032927.3(identity)|entrezgene/locuslink:85013(identity)	-	-	isoform-comment:No experimental confirmation available.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:fsGbysnORUH/y9LqInPSyP55P4k9606	intact-crc:41551D7B7A01AE74|rigid:dFpOkwbM+BaQW+GZi1bvd/dCBO8	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q3KNS6	uniprotkb:P40763	intact:EBI-4395439|uniprotkb:Q3KNS7|uniprotkb:Q6ZNN0|uniprotkb:Q7Z657|uniprotkb:A0A075B6T0|ensembl:ENSP00000429266	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:zn829_human(display_long)|uniprotkb:ZNF829(gene name)|psi-mi:ZNF829(display_short)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694939|imex:IM-22632-207	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011525235.1|refseq:NP_001032309.2|refseq:NP_001165450.1|refseq:XP_005258933.1|ensembl:ENSG00000185869(gene)|ensembl:ENST00000391711(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q3KNS6|refseq:NM_001037232.3(identity)|entrezgene/locuslink:374899(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:c0t+1le/UyFvSKKZAsToELKNZUE9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:D539067711D795BD|rigid:D9vrGftPWxiVmvWsNzat1m/P9vw	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q3KNS6	uniprotkb:Q9UKG1	intact:EBI-4395439|uniprotkb:Q3KNS7|uniprotkb:Q6ZNN0|uniprotkb:Q7Z657|uniprotkb:A0A075B6T0|ensembl:ENSP00000429266	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:zn829_human(display_long)|uniprotkb:ZNF829(gene name)|psi-mi:ZNF829(display_short)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694954|imex:IM-22632-208	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011525235.1|refseq:NP_001032309.2|refseq:NP_001165450.1|refseq:XP_005258933.1|ensembl:ENSG00000185869(gene)|ensembl:ENST00000391711(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q3KNS6|refseq:NM_001037232.3(identity)|entrezgene/locuslink:374899(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:c0t+1le/UyFvSKKZAsToELKNZUE9606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:563C0B87BE490285|rigid:A8DhfdVGowL2AiKFoAua0wlJZzg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q3B8N2-2	uniprotkb:Q8NEU8	intact:EBI-10694969|ensembl:ENSP00000315564	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	psi-mi:q3b8n2-2(display_long)|uniprotkb:LGALS9B(gene name)|psi-mi:LGALS9B(display_short)|uniprotkb:Galectin-9-like protein A(gene name synonym)	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694973|imex:IM-22632-209	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-10240775(isoform-parent)|ensembl:ENSG00000170298(gene)|ensembl:ENST00000324290(transcript)|uniprotkb:Q3B8N2-2(isoform-parent)|entrezgene/locuslink:654346(identity)|refseq:NM_001042685.1(identity)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	-	isoform-comment:No experimental confirmation available.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FES (P07332), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:e44N/cll4hZr6nWfUMKICujSwgY9606	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	intact-crc:9979F4FC6614A8AC|rigid:puYx2Ru+Xn7VyH6q1nUlwKbsGpo	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:Q18PE1	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-3046647|ensembl:ENSP00000344432|uniprotkb:E9PB56|uniprotkb:Q8NBC1|uniprotkb:Q86XG5|uniprotkb:Q8N2J3|uniprotkb:A2A499|uniprotkb:Q6P6A6|uniprotkb:A2RRD4	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:dok7_human(display_long)|uniprotkb:DOK7(gene name)|psi-mi:DOK7(display_short)|uniprotkb:C4orf25(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 7(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695003|imex:IM-22632-211	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	ensembl:ENSG00000175920(gene)|ensembl:ENST00000340083(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045202"(synapse)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037746|interpro:IPR037747|interpro:IPR037748|refseq:NP_001288000.1|refseq:NP_001158145.1|refseq:NP_775931.3|refseq:NP_001243825.1|refseq:NM_173660.4(identity)|entrezgene/locuslink:285489(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:RNSUGsyQVitqfrm+mTmzf0fZHR49606	intact-crc:5D5A4B40D8DED1C9|rigid:CfjRkiU1yZ2FzBc9pnfYRjCVoAg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q18PE1	uniprotkb:P46108-2	intact:EBI-3046647|ensembl:ENSP00000344432|uniprotkb:E9PB56|uniprotkb:Q8NBC1|uniprotkb:Q86XG5|uniprotkb:Q8N2J3|uniprotkb:A2A499|uniprotkb:Q6P6A6|uniprotkb:A2RRD4	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:dok7_human(display_long)|uniprotkb:DOK7(gene name)|psi-mi:DOK7(display_short)|uniprotkb:C4orf25(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 7(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10694988|imex:IM-22632-210	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000175920(gene)|ensembl:ENST00000340083(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045202"(synapse)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037746|interpro:IPR037747|interpro:IPR037748|refseq:NP_001288000.1|refseq:NP_001158145.1|refseq:NP_775931.3|refseq:NP_001243825.1|refseq:NM_173660.4(identity)|entrezgene/locuslink:285489(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:RNSUGsyQVitqfrm+mTmzf0fZHR49606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:5D62F0CA3E1D628E|rigid:Pf/NqA0c57coq6f8qfEpOUswHaE	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q16643	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-351394|uniprotkb:Q9UFZ5|uniprotkb:B2RBG0|ensembl:ENSP00000308532|intact:EBI-4404710|uniprotkb:A8MV58	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:dreb_human(display_long)|uniprotkb:DBN1(gene name)|psi-mi:DBN1(display_short)|uniprotkb:Developmentally-regulated brain protein(gene name synonym)|uniprotkb:D0S117E(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695018|imex:IM-22632-212	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	refseq:NP_004386.2|refseq:NP_543157.1|refseq:XP_005265884.1|ensembl:ENSG00000113758(gene)|ensembl:ENST00000309007(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0042641"(actomyosin)|go:"GO:0030425"(dendrite)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051015"(actin filament binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028438|interpro:IPR029006|mint:Q16643|go:"GO:0030426"(growth cone)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031915"(positive regulation of synaptic plasticity)|rcsb pdb:5Y1Z|rcsb pdb:5ZZ9|reactome:R-HSA-9013405|reactome:R-HSA-9013407|reactome:R-HSA-9013418|reactome:R-HSA-9013422|go:"GO:0032507"(maintenance of protein location in cell)|refseq:XP_016864629.1|refseq:NM_004395.3(identity)|entrezgene/locuslink:1627(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:0+VPJM5mTuG2jzmzGG3iLswmCUc9606	intact-crc:B37A815D93EDC8E5|rigid:bK7RLAO4Bt4GqOKnUzGxYpPX+AE	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16643	uniprotkb:Q5R372-2	intact:EBI-351394|uniprotkb:Q9UFZ5|uniprotkb:B2RBG0|ensembl:ENSP00000308532|intact:EBI-4404710|uniprotkb:A8MV58	intact:EBI-10692254|ensembl:ENSP00000350027	psi-mi:dreb_human(display_long)|uniprotkb:DBN1(gene name)|psi-mi:DBN1(display_short)|uniprotkb:Developmentally-regulated brain protein(gene name synonym)|uniprotkb:D0S117E(gene name synonym)	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695033|imex:IM-22632-213	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004386.2|refseq:NP_543157.1|refseq:XP_005265884.1|ensembl:ENSG00000113758(gene)|ensembl:ENST00000309007(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0042641"(actomyosin)|go:"GO:0030425"(dendrite)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051015"(actin filament binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028438|interpro:IPR029006|mint:Q16643|go:"GO:0030426"(growth cone)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031915"(positive regulation of synaptic plasticity)|rcsb pdb:5Y1Z|rcsb pdb:5ZZ9|reactome:R-HSA-9013405|reactome:R-HSA-9013407|reactome:R-HSA-9013418|reactome:R-HSA-9013422|go:"GO:0032507"(maintenance of protein location in cell)|refseq:XP_016864629.1|refseq:NM_004395.3(identity)|entrezgene/locuslink:1627(identity)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:0+VPJM5mTuG2jzmzGG3iLswmCUc9606	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	intact-crc:F9897B3DB40A3030|rigid:nxiJ4OTRMOsHHb53mH8iovFyeaE	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15672	uniprotkb:P40763	intact:EBI-1797287|uniprotkb:Q92487|uniprotkb:Q99804|uniprotkb:A4D128|ensembl:ENSP00000242261	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:twst1_human(display_long)|uniprotkb:H-twist(gene name synonym)|uniprotkb:TWIST1(gene name)|psi-mi:TWIST1(display_short)|uniprotkb:TWIST(gene name synonym)|uniprotkb:BHLHA38(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 38(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695048|imex:IM-22632-214	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000465.1|refseq:XP_011513798.1|dip:DIP-45974N|ensembl:ENSG00000122691(gene)|ensembl:ENST00000242261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0001843"(neural tube closure)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032502"(developmental process)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035359"(negative regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0060900"(embryonic camera-type eye formation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0070888"(E-box binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000276"(negative regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000780"(negative regulation of double-strand break repair)|go:"GO:2000793"(cell proliferation involved in heart valve development)|go:"GO:2000802"(positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015789(Twist)|interpro:IPR036638|rcsb pdb:2MJV|reactome:R-HSA-6785807|reactome:R-HSA-8878166|reactome:R-HSA-8939902|refseq:NM_000474.3(identity)|entrezgene/locuslink:7291(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|entrezgene/locuslink:6774(identity)|refseq:NM_139276.2(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:1+WEEh0ruAAKCxlJQCVzBqTrhIM9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:B603734C04821046|rigid:oPCUu5hV4Np0/jr8Ossb0icLo18	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q15435-3	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-10695066|ensembl:ENSP00000385022	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:q15435-3(display_long)|uniprotkb:PPP1R7(gene name)|psi-mi:PPP1R7(display_short)|uniprotkb:Protein phosphatase 1 regulatory subunit 22(gene name synonym)|uniprotkb:SDS22(gene name synonym)|uniprotkb:sds22beta1(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695063|imex:IM-22632-215	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	intact:EBI-1024281(isoform-parent)|ensembl:ENSG00000115685(gene)|ensembl:ENST00000406106(transcript)|uniprotkb:Q15435-3(isoform-parent)|entrezgene/locuslink:5510(identity)|refseq:NM_001282410.1(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:cJCKB1W0OoVTBEjlLdLVL2FKsJ49606	intact-crc:9F88D212123CD7F7|rigid:3Mg+sXZdl58aNVPdfrmrU/2sbRM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15027	uniprotkb:P62993	intact:EBI-751746|uniprotkb:Q53XN9|ensembl:ENSP00000158762|ensembl:ENSP00000499859	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:acap1_human(display_long)|uniprotkb:ACAP1(gene name)|psi-mi:ACAP1(display_short)|uniprotkb:Centaurin-beta-1(gene name synonym)|uniprotkb:CENTB1(gene name synonym)|uniprotkb:KIAA0050(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695082|imex:IM-22632-216	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055531.1|interpro:IPR038508|mint:Q15027|rcsb pdb:3JUE|rcsb pdb:3T9K|rcsb pdb:4CKG|rcsb pdb:4CKH|rcsb pdb:4F1P|rcsb pdb:4NSW|rcsb pdb:5H3D|ensembl:ENSG00000072818(gene)|ensembl:ENSG00000288169(gene)|ensembl:ENST00000158762(transcript)|ensembl:ENST00000672212(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR036770|interpro:IPR037278|entrezgene/locuslink:9744(identity)|refseq:NM_014716.3(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), SYK (P43405)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:pdHptA2uWwLfGAtHieVj+hm1udw9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:05DF5760D13FA16E|rigid:vZECfRDHzgIs5K2hwUmaNW9QQLU	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15027	uniprotkb:Q5R372-2	intact:EBI-751746|uniprotkb:Q53XN9|ensembl:ENSP00000158762|ensembl:ENSP00000499859	intact:EBI-10692254|ensembl:ENSP00000350027	psi-mi:acap1_human(display_long)|uniprotkb:ACAP1(gene name)|psi-mi:ACAP1(display_short)|uniprotkb:Centaurin-beta-1(gene name synonym)|uniprotkb:CENTB1(gene name synonym)|uniprotkb:KIAA0050(gene name synonym)	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695097|imex:IM-22632-217	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055531.1|interpro:IPR038508|mint:Q15027|rcsb pdb:3JUE|rcsb pdb:3T9K|rcsb pdb:4CKG|rcsb pdb:4CKH|rcsb pdb:4F1P|rcsb pdb:4NSW|rcsb pdb:5H3D|ensembl:ENSG00000072818(gene)|ensembl:ENSG00000288169(gene)|ensembl:ENST00000158762(transcript)|ensembl:ENST00000672212(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR036770|interpro:IPR037278|entrezgene/locuslink:9744(identity)|refseq:NM_014716.3(identity)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:pdHptA2uWwLfGAtHieVj+hm1udw9606	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	intact-crc:1B17560630F29B41|rigid:xDCTGDNaTukiYh5nmSa+yDL4I/Y	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14847	uniprotkb:P40763	intact:EBI-742828|uniprotkb:Q96ED2|uniprotkb:Q96IG0|ensembl:ENSP00000325240|ensembl:ENSP00000392853|uniprotkb:B4DGQ0	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:lasp1_human(display_long)|uniprotkb:Metastatic lymph node gene 50 protein(gene name synonym)|uniprotkb:LASP1(gene name)|psi-mi:LASP1(display_short)|uniprotkb:MLN50(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695112|imex:IM-22632-218	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006139.1|refseq:NP_001258537.1|ensembl:ENSG00000002834(gene)|ensembl:ENST00000318008(transcript)|ensembl:ENST00000435347(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006811"(ion transport)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|interpro:IPR000900(Nebulin 35 residue motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR035630|interpro:IPR036028|mint:Q14847|rcsb pdb:3I35|refseq:NM_006148.3(identity)|entrezgene/locuslink:3927(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Oa+FdJXeQhahYTqVrHYk6yBrUWI9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:976E10AAD88CEE97|rigid:BaX/N0CjH+B1nLB02HXFs45Eqzc	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14847	uniprotkb:P46108-2	intact:EBI-742828|uniprotkb:Q96ED2|uniprotkb:Q96IG0|ensembl:ENSP00000325240|ensembl:ENSP00000392853|uniprotkb:B4DGQ0	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:lasp1_human(display_long)|uniprotkb:Metastatic lymph node gene 50 protein(gene name synonym)|uniprotkb:LASP1(gene name)|psi-mi:LASP1(display_short)|uniprotkb:MLN50(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695127|imex:IM-22632-219	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006139.1|refseq:NP_001258537.1|ensembl:ENSG00000002834(gene)|ensembl:ENST00000318008(transcript)|ensembl:ENST00000435347(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006811"(ion transport)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|interpro:IPR000900(Nebulin 35 residue motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR035630|interpro:IPR036028|mint:Q14847|rcsb pdb:3I35|refseq:NM_006148.3(identity)|entrezgene/locuslink:3927(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Oa+FdJXeQhahYTqVrHYk6yBrUWI9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:4897360024B5FCD5|rigid:hcvX0/4E4hxcqpSl1Md0hTxZOLI	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q14847	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-742828|uniprotkb:Q96ED2|uniprotkb:Q96IG0|ensembl:ENSP00000325240|ensembl:ENSP00000392853|uniprotkb:B4DGQ0	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:lasp1_human(display_long)|uniprotkb:Metastatic lymph node gene 50 protein(gene name synonym)|uniprotkb:LASP1(gene name)|psi-mi:LASP1(display_short)|uniprotkb:MLN50(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695142|imex:IM-22632-220	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_006139.1|refseq:NP_001258537.1|ensembl:ENSG00000002834(gene)|ensembl:ENST00000318008(transcript)|ensembl:ENST00000435347(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006811"(ion transport)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|interpro:IPR000900(Nebulin 35 residue motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR035630|interpro:IPR036028|mint:Q14847|rcsb pdb:3I35|refseq:NM_006148.3(identity)|entrezgene/locuslink:3927(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:Oa+FdJXeQhahYTqVrHYk6yBrUWI9606	intact-crc:CF36222CD2C668DB|rigid:VZcThSwTkBHIDVT+XglGtwk1t98	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14765	uniprotkb:O14796	intact:EBI-1186538|uniprotkb:Q96NZ6|ensembl:ENSP00000351255|ensembl:ENSP00000376134	intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906	psi-mi:stat4_human(display_long)|uniprotkb:STAT4(gene name)|psi-mi:STAT4(display_short)	psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695157|imex:IM-22632-221	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003142.1|refseq:XP_006712782.1|refseq:NP_001230764.1|refseq:XP_011510007.1|ensembl:ENSG00000138378(gene)|ensembl:ENST00000358470(transcript)|ensembl:ENST00000392320(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR029839|interpro:IPR035856|interpro:IPR036535|interpro:IPR036860|mint:Q14765|reactome:R-HSA-8854691|reactome:R-HSA-8950505|reactome:R-HSA-8984722|reactome:R-HSA-9020591|reactome:R-HSA-9020933|reactome:R-HSA-9020958|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-39854N|refseq:NM_001243835.1(identity)|entrezgene/locuslink:6775(identity)	refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933|entrezgene/locuslink:117157(identity)|refseq:NM_053282.4(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451)."|comment:"The interaction failed to show if a kinase-dead version of ABL2 (P42684) was used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:z6Wvolbix1XQBOsVA/MIxXi56qU9606	rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606	intact-crc:31E2543A12098ABE|rigid:/yz8FajxoBvSLsO4muNkEHW1arA	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14765	uniprotkb:P46108	intact:EBI-1186538|uniprotkb:Q96NZ6|ensembl:ENSP00000351255|ensembl:ENSP00000376134	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:stat4_human(display_long)|uniprotkb:STAT4(gene name)|psi-mi:STAT4(display_short)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695173|imex:IM-22632-222	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003142.1|refseq:XP_006712782.1|refseq:NP_001230764.1|refseq:XP_011510007.1|ensembl:ENSG00000138378(gene)|ensembl:ENST00000358470(transcript)|ensembl:ENST00000392320(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR029839|interpro:IPR035856|interpro:IPR036535|interpro:IPR036860|mint:Q14765|reactome:R-HSA-8854691|reactome:R-HSA-8950505|reactome:R-HSA-8984722|reactome:R-HSA-9020591|reactome:R-HSA-9020933|reactome:R-HSA-9020958|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-39854N|refseq:NM_001243835.1(identity)|entrezgene/locuslink:6775(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:z6Wvolbix1XQBOsVA/MIxXi56qU9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:CB89EAA4743CFCC1|rigid:ZESLbDCf4OwArykDIKQPmGZ+Foc	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14457	uniprotkb:P07947	intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym)	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695188|imex:IM-22632-223	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1|entrezgene/locuslink:8678(identity)|refseq:NM_003766.3(identity)	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439|refseq:NM_005433.3(identity)|entrezgene/locuslink:7525(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FER (P16591), FES (P07332), FGR (P09769), HCK (P08631), SYK (P43405), YES1 (P07947)."|comment:"The interaction failed to show if kinase-dead versions of ABL2 (P42684) or FES (P07332) were used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	intact-crc:DDC7C826E87425C8|rigid:uiWqlqs08ES80MtddGIzjFsHSrg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UN19	uniprotkb:Q13829	intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602	intact:EBI-2505861|uniprotkb:B7Z6M4|uniprotkb:Q5TZQ1|ensembl:ENSP00000226225	psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name)	psi-mi:bacd2_human(display_long)|uniprotkb:BACURD2(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein TNFAIP1(gene name synonym)|uniprotkb:Protein B12(gene name synonym)|uniprotkb:TNFAIP1(gene name)|psi-mi:TNFAIP1(display_short)|uniprotkb:EDP1(gene name synonym)|uniprotkb:Tumor necrosis factor, alpha-induced protein 1, endothelial(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695204|imex:IM-22632-224	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695|entrezgene/locuslink:27071(identity)|refseq:NM_014395.2(identity)	refseq:NP_066960.1|ensembl:ENSG00000109079(gene)|ensembl:ENST00000226225(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030332"(cyclin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q13829|reactome:R-HSA-9696264|reactome:R-HSA-9696270|refseq:NM_021137.4(identity)|entrezgene/locuslink:7126(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:YYI49xKbndaB1MfL/QEovp2BF009606	rogid:8vM9HnNmkirDbJRETV/TeE8pONY9606	intact-crc:C22A1D2D847A6179|rigid:wZpWosAvbzNzLucW3qMxNwL5o/U	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03112	uniprotkb:Q92569	intact:EBI-1384862|uniprotkb:Q16122|uniprotkb:Q99917|uniprotkb:C9JAK0|uniprotkb:Q5HYI1|uniprotkb:Q6MZS6|uniprotkb:Q8NEI5|uniprotkb:A1L4F3|uniprotkb:A8KA00|uniprotkb:B7Z8W7|uniprotkb:B7ZLQ3|uniprotkb:B7ZLQ4|uniprotkb:D3DNP7|ensembl:ENSP00000417899|intact:EBI-8475192|intact:MINT-8417693|uniprotkb:E7EQ57|uniprotkb:Q13465|uniprotkb:Q13466|uniprotkb:Q6FH90	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:mecom_human(display_long)|uniprotkb:MECOM(gene name)|psi-mi:MECOM(display_short)|uniprotkb:EVI1(gene name synonym)|uniprotkb:Ecotropic virus integration site 1 protein homolog(gene name synonym)|uniprotkb:MDS1(gene name synonym)|uniprotkb:Myelodysplasia syndrome 1 protein(gene name synonym)|uniprotkb:Myelodysplasia syndrome-associated protein 1(gene name synonym)|uniprotkb:MDS1 and EVI1 complex locus protein(gene name synonym)|uniprotkb:PRDM3(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695219|imex:IM-22632-225	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001098547.3|refseq:NP_001098548.2|refseq:NP_001157471.1|refseq:NP_001157472.1|refseq:NP_001192123.1|refseq:NP_004982.2|refseq:NP_005232.2|ensembl:ENSG00000085276(gene)|ensembl:ENST00000494292(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0071425"(hematopoietic stem cell proliferation)|interpro:IPR001214(SET)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR044411|mint:Q03112|rcsb pdb:6BW3|reactome:R-HSA-3214841|reactome:R-HSA-8943724|interpro:IPR036236|refseq:XP_016861363.1|refseq:XP_016861364.1|refseq:XP_016861365.1|refseq:XP_005247278.1|refseq:XP_005247280.1|refseq:XP_005247272.1|dip:DIP-38639N|refseq:XP_005247276.1|refseq:XP_005247277.1|entrezgene/locuslink:2122(identity)|refseq:XM_006713537.1(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2018/04/06	rogid:MAlEIuVZS4+BNoy50jejv2O30WA9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:486729F34EB27E68|rigid:fFxY5bzv33y+5MXuz0J+C5aR1yo	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5R372-2	uniprotkb:Q03112	intact:EBI-10692254|ensembl:ENSP00000350027	intact:EBI-1384862|uniprotkb:Q16122|uniprotkb:Q99917|uniprotkb:C9JAK0|uniprotkb:Q5HYI1|uniprotkb:Q6MZS6|uniprotkb:Q8NEI5|uniprotkb:A1L4F3|uniprotkb:A8KA00|uniprotkb:B7Z8W7|uniprotkb:B7ZLQ3|uniprotkb:B7ZLQ4|uniprotkb:D3DNP7|ensembl:ENSP00000417899|intact:EBI-8475192|intact:MINT-8417693|uniprotkb:E7EQ57|uniprotkb:Q13465|uniprotkb:Q13466|uniprotkb:Q6FH90	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:mecom_human(display_long)|uniprotkb:MECOM(gene name)|psi-mi:MECOM(display_short)|uniprotkb:EVI1(gene name synonym)|uniprotkb:Ecotropic virus integration site 1 protein homolog(gene name synonym)|uniprotkb:MDS1(gene name synonym)|uniprotkb:Myelodysplasia syndrome 1 protein(gene name synonym)|uniprotkb:Myelodysplasia syndrome-associated protein 1(gene name synonym)|uniprotkb:MDS1 and EVI1 complex locus protein(gene name synonym)|uniprotkb:PRDM3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695234|imex:IM-22632-226	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	refseq:NP_001098547.3|refseq:NP_001098548.2|refseq:NP_001157471.1|refseq:NP_001157472.1|refseq:NP_001192123.1|refseq:NP_004982.2|refseq:NP_005232.2|ensembl:ENSG00000085276(gene)|ensembl:ENST00000494292(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0071425"(hematopoietic stem cell proliferation)|interpro:IPR001214(SET)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR044411|mint:Q03112|rcsb pdb:6BW3|reactome:R-HSA-3214841|reactome:R-HSA-8943724|interpro:IPR036236|refseq:XP_016861363.1|refseq:XP_016861364.1|refseq:XP_016861365.1|refseq:XP_005247278.1|refseq:XP_005247280.1|refseq:XP_005247272.1|dip:DIP-38639N|refseq:XP_005247276.1|refseq:XP_005247277.1|entrezgene/locuslink:2122(identity)|refseq:XM_006713537.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), SYK (P43405)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2018/04/06	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	rogid:MAlEIuVZS4+BNoy50jejv2O30WA9606	intact-crc:D9FFC1837B9778F7|rigid:bqT3Gw/k0vuCcK2LncEvdXLqIo8	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q13191	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-744027|uniprotkb:Q63Z43|uniprotkb:A8K9S7|uniprotkb:Q13192|uniprotkb:Q13193|uniprotkb:Q3LIC0|uniprotkb:Q8IVC5|uniprotkb:B7WNM4|intact:EBI-28969458|ensembl:ENSP00000377598|intact:EBI-8051403|intact:MINT-7907019	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:cblb_human(display_long)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695264|imex:IM-22632-228	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_733762.2|refseq:NP_001308717.1|ensembl:ENSP00000377598|ensembl:ENST00000403724|ensembl:ENSP00000384816|ensembl:ENST00000405772|ensembl:ENSP00000384938|refseq:XP_011511559.1|ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q13191|rcsb pdb:2AK5|rcsb pdb:2BZ8|rcsb pdb:2DO6|rcsb pdb:2J6F|rcsb pdb:2JNH|rcsb pdb:2LDR|rcsb pdb:2OOA|rcsb pdb:2OOB|rcsb pdb:3PFV|rcsb pdb:3VGO|rcsb pdb:3ZNI|reactome:R-HSA-983168|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|dip:DIP-33091N|entrezgene/locuslink:868(identity)|refseq:NM_170662.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606	intact-crc:48CFE50E2B813A42|rigid:D5/N28Npe7FEobUizB151kissYw	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13191	uniprotkb:P46108-2	intact:EBI-744027|uniprotkb:Q63Z43|uniprotkb:A8K9S7|uniprotkb:Q13192|uniprotkb:Q13193|uniprotkb:Q3LIC0|uniprotkb:Q8IVC5|uniprotkb:B7WNM4|intact:EBI-28969458|ensembl:ENSP00000377598|intact:EBI-8051403|intact:MINT-7907019	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:cblb_human(display_long)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695249|imex:IM-22632-227	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_733762.2|refseq:NP_001308717.1|ensembl:ENSP00000377598|ensembl:ENST00000403724|ensembl:ENSP00000384816|ensembl:ENST00000405772|ensembl:ENSP00000384938|refseq:XP_011511559.1|ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q13191|rcsb pdb:2AK5|rcsb pdb:2BZ8|rcsb pdb:2DO6|rcsb pdb:2J6F|rcsb pdb:2JNH|rcsb pdb:2LDR|rcsb pdb:2OOA|rcsb pdb:2OOB|rcsb pdb:3PFV|rcsb pdb:3VGO|rcsb pdb:3ZNI|reactome:R-HSA-983168|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|dip:DIP-33091N|entrezgene/locuslink:868(identity)|refseq:NM_170662.3(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:377D7740CC0B8D2B|rigid:pUc8+3qlF688qmvoNaB+aV3QeQY	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13191	uniprotkb:Q9UKG1	intact:EBI-744027|uniprotkb:Q63Z43|uniprotkb:A8K9S7|uniprotkb:Q13192|uniprotkb:Q13193|uniprotkb:Q3LIC0|uniprotkb:Q8IVC5|uniprotkb:B7WNM4|intact:EBI-28969458|ensembl:ENSP00000377598|intact:EBI-8051403|intact:MINT-7907019	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:cblb_human(display_long)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695279|imex:IM-22632-229	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_733762.2|refseq:NP_001308717.1|ensembl:ENSP00000377598|ensembl:ENST00000403724|ensembl:ENSP00000384816|ensembl:ENST00000405772|ensembl:ENSP00000384938|refseq:XP_011511559.1|ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q13191|rcsb pdb:2AK5|rcsb pdb:2BZ8|rcsb pdb:2DO6|rcsb pdb:2J6F|rcsb pdb:2JNH|rcsb pdb:2LDR|rcsb pdb:2OOA|rcsb pdb:2OOB|rcsb pdb:3PFV|rcsb pdb:3VGO|rcsb pdb:3ZNI|reactome:R-HSA-983168|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|dip:DIP-33091N|entrezgene/locuslink:868(identity)|refseq:NM_170662.3(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:DD1E113CD26B0803|rigid:VCLmvgmS6GswxPilrRMAT3ZYrnE	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14543	uniprotkb:Q13061-3	intact:EBI-714146|uniprotkb:O14509|ensembl:ENSP00000330341	intact:EBI-10695294|ensembl:ENSP00000437684	psi-mi:socs3_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 3(gene name synonym)|uniprotkb:SOCS3(gene name)|psi-mi:SOCS3(display_short)|uniprotkb:CIS3(gene name synonym)|uniprotkb:SSI3(gene name synonym)	psi-mi:q13061-3(display_long)|uniprotkb:TRDN(gene name)|psi-mi:TRDN(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695298|imex:IM-22632-230	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O14543|reactome:R-HSA-1059683|reactome:R-HSA-2586552|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8849474|reactome:R-HSA-8939242|reactome:R-HSA-8951664|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|go:"GO:0050728"(negative regulation of inflammatory response)|ensembl:ENSG00000184557(gene)|ensembl:ENST00000330871(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|refseq:NP_003946.3|entrezgene/locuslink:9021(identity)|refseq:NM_003955.4(identity)	intact:EBI-10757323(isoform-parent)|ensembl:ENSG00000186439(gene)|ensembl:ENST00000542443(transcript)|entrezgene/locuslink:10345(identity)|refseq:NM_001256022.1(identity)	-	-	isoform-comment:No experimental confirmation available.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8HnU9EL52BGdud2WFZwYsv5R22I9606	rogid:i4UiplUvJATqZ4qDj6kEPJeGc109606	intact-crc:360EF5E151934606|rigid:SmxEQrY/KkZMhokbVhvl+1+n8dE	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12841	uniprotkb:P46108	intact:EBI-2349801|uniprotkb:Q549Z0|uniprotkb:A8K523|uniprotkb:B4DTT5|uniprotkb:D3DN90|ensembl:ENSP00000295633	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:fstl1_human(display_long)|uniprotkb:FSTL1(gene name)|psi-mi:FSTL1(display_short)|uniprotkb:FRP(gene name synonym)|uniprotkb:Follistatin-like protein 1(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695313|imex:IM-22632-231	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009016.1|ensembl:ENSG00000163430(gene)|ensembl:ENST00000295633(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0008201"(heparin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR036058|reactome:R-HSA-201451|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NM_007085.4(identity)|entrezgene/locuslink:11167(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FRK (P42685), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:2Y10WyTpml76Ksjw+X7dXUozFg09606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:DAA715A65883F867|rigid:EdcF1/7vBJfy6RQf/6CaO51/xTg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08AM6	uniprotkb:P46108	intact:EBI-2107455|uniprotkb:Q13174|uniprotkb:Q6IA12|uniprotkb:Q7L4Y1|uniprotkb:Q9BW96|uniprotkb:Q9H6V6|uniprotkb:B3KPJ5|uniprotkb:B3KSM8|ensembl:ENSP00000261776	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:vac14_human(display_long)|uniprotkb:Tax1-binding protein 2(gene name synonym)|uniprotkb:VAC14(gene name)|psi-mi:VAC14(display_short)|uniprotkb:TAX1BP2(gene name synonym)|uniprotkb:TRX(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695328|imex:IM-22632-232	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060522.3|ensembl:ENSG00000103043(gene)|ensembl:ENST00000261776(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000306"(extrinsic component of vacuolar membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070772"(PAS complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021841|interpro:IPR026825|mint:Q08AM6|rcsb pdb:7K1Y|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|refseq:NM_018052.3(identity)|entrezgene/locuslink:55697(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:S9syIZ/DKHNbOM0Nw9oZP5F+AvA9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:04B2A93F43015A24|rigid:TloMdEDcCI9pVAMVpi8dcvxMDvM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q06187	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695343|imex:IM-22632-233	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N|refseq:NM_000061.2(identity)|entrezgene/locuslink:695(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	intact-crc:714A05F71A739256|rigid:pS3OvFBl0D1pTko7GV5we+dBtJM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03181-2	uniprotkb:P40763	intact:EBI-10223258|ensembl:ENSP00000337063	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:q03181-2(display_long)|uniprotkb:PPARD(gene name)|psi-mi:PPARD(display_short)|uniprotkb:NR1C2(gene name synonym)|uniprotkb:NUCI(gene name synonym)|uniprotkb:Nuclear hormone receptor 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group C member 2(gene name synonym)|uniprotkb:PPARB(gene name synonym)|uniprotkb:Peroxisome proliferator-activated receptor beta(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695358|imex:IM-22632-234	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000112033(gene)|ensembl:ENST00000337400(transcript)|intact:EBI-6426768(isoform-parent)|uniprotkb:Q03181-2(isoform-parent)|refseq:NM_177435.2(identity)|entrezgene/locuslink:5467(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:f/1hsB8raZhYd9o39f/T5XI5oWs9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:4B49566D3390CF63|rigid:j0ftkdZRwzRy63SBIwr6tEmOQes	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:P68402	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-713724|uniprotkb:A8DPS6|uniprotkb:Q6IBR6|uniprotkb:O00687|uniprotkb:Q29459|ensembl:ENSP00000435289|uniprotkb:A8DPS5|uniprotkb:E9PEJ5|uniprotkb:A8DPS7|uniprotkb:E9PLP3	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:pa1b2_human(display_long)|uniprotkb:PAF acetylhydrolase 30 kDa subunit(gene name synonym)|uniprotkb:PAF-AH subunit beta(gene name synonym)|uniprotkb:PAFAH1B2(gene name)|psi-mi:PAFAH1B2(display_short)|uniprotkb:PAFAHB(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695373|imex:IM-22632-235	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	ensembl:ENSG00000168092(gene)|ensembl:ENST00000527958(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003847"(1-alkyl-2-acetylglycerophosphocholine esterase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008247"(1-alkyl-2-acetylglycerophosphocholine esterase complex)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047179"(platelet-activating factor acetyltransferase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR013830(Esterase, SGNH hydrolase-type)|interpro:IPR036514|rcsb pdb:1VYH|reactome:R-HSA-6798695|reactome:R-HSA-6811436|refseq:NP_001296360.1|refseq:NP_001171677.1|refseq:NP_002563.1|refseq:NP_001171676.1|refseq:NP_001171675.1|refseq:NM_002572.3(identity)|entrezgene/locuslink:5049(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:lor3gsaIQ071mc4l0OfQelfuQdg9606	intact-crc:61756429870B9B2A|rigid:02oJ9eRitewDt/DBR831ItK6uy8	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:P60409	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-10172290|uniprotkb:Q70LJ2|uniprotkb:Q0VDJ8|ensembl:ENSP00000476821	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:kr107_human(display_long)|uniprotkb:KRTAP10-7(gene name)|psi-mi:KRTAP10-7(display_short)|uniprotkb:High sulfur keratin-associated protein 10.7(gene name synonym)|uniprotkb:KAP10.7(gene name synonym)|uniprotkb:KAP18-7(gene name synonym)|uniprotkb:KRTAP10.7(gene name synonym)|uniprotkb:KRTAP18-7(gene name synonym)|uniprotkb:KRTAP18.7(gene name synonym)|uniprotkb:Keratin-associated protein 10.7(gene name synonym)|uniprotkb:Keratin-associated protein 18-7(gene name synonym)|uniprotkb:Keratin-associated protein 18.7(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695392|imex:IM-22632-236	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_941962.1|ensembl:ENSG00000272804(gene)|ensembl:ENST00000609664(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0045095"(keratin filament)|interpro:IPR002494(Keratin, high sulphur B2 protein)|reactome:R-HSA-6805567|entrezgene/locuslink:386675(identity)|refseq:NM_198689.2(identity)	-	crc64:6C00632211C8012D	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2020/12/11	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:XmtWE6zSOr/RhRJH9yR31sPW1eY9606	intact-crc:11F3081997A130D5|rigid:PJpYGEjyJj+4uzvmV4eTADhM86M	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:P55072	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695407|imex:IM-22632-237	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N|refseq:NM_007126.3(identity)|entrezgene/locuslink:7415(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), SRC (P12931), SYK (P43405), TNK1 (Q13470), YES1 (P07947)."|comment:"The interaction failed to show if kinase-dead versions of ABL2 (P42684), TNK1 (Q13470) or FYN (P06241) were used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606	intact-crc:4C1A130E8BCCE200|rigid:p/r1PEfHpVYXmq6Zo4T+A4jzgGQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:P55072	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695423|imex:IM-22632-238	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N|refseq:NM_007126.3(identity)|entrezgene/locuslink:7415(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606	intact-crc:65FAD8E6BF28CDEF|rigid:vZJtzodDGZ4WZVMc7/P0Xy4rXag	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:P53672	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-750444|uniprotkb:Q9Y562|uniprotkb:Q4ZFX0|ensembl:ENSP00000295728|ensembl:ENSP00000375946	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:crba2_human(display_long)|uniprotkb:Beta-A2 crystallin(gene name synonym)|uniprotkb:CRYBA2(gene name)|psi-mi:CRYBA2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695438|imex:IM-22632-239	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_476434.1|refseq:NP_476435.1|ensembl:ENSG00000163499(gene)|ensembl:ENST00000295728(transcript)|ensembl:ENST00000392096(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|mint:P53672|entrezgene/locuslink:1412(identity)|refseq:NM_057094.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:/WkdaQ4LTxa9mpIiOwVuhd375mE9606	intact-crc:F5853C2CE2F36B99|rigid:QiwDJtJbxb1JQtZfon0yBo8GD+g	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52630	uniprotkb:Q8TEW6	intact:EBI-1546963|uniprotkb:Q16430|uniprotkb:Q16431|uniprotkb:Q9UDL4|intact:EBI-10989287|uniprotkb:B4DLC7|uniprotkb:G3V2M6|ensembl:ENSP00000315768	intact:EBI-6918542|ensembl:ENSP00000344277|ensembl:ENSP00000455128|uniprotkb:O75209|uniprotkb:Q9BTP2|uniprotkb:Q9NVV3	psi-mi:stat2_human(display_long)|uniprotkb:p113(gene name synonym)|uniprotkb:STAT2(gene name)|psi-mi:STAT2(display_short)	psi-mi:dok4_human(display_long)|uniprotkb:DOK4(gene name)|psi-mi:DOK4(display_short)|uniprotkb:Downstream of tyrosine kinase 4(gene name synonym)|uniprotkb:Insulin receptor substrate 5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695453|imex:IM-22632-240	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005410.1|refseq:NP_938146.1|dip:DIP-38511N|ensembl:ENSG00000170581(gene)|ensembl:ENST00000314128(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0090140"(regulation of mitochondrial fission)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860|mint:P52630|rcsb pdb:2KA4|rcsb pdb:6UX2|rcsb pdb:6WCZ|reactome:R-HSA-8854691|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9679191|entrezgene/locuslink:6773(identity)|refseq:NM_005419.3(identity)	ensembl:ENSG00000125170(gene)|ensembl:ENST00000340099(transcript)|ensembl:ENST00000569548(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0043410"(positive regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_060580.2|refseq:XP_005256100.1|entrezgene/locuslink:55715(identity)|refseq:NM_018110.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uA0lxm5vmrLClQRP7NItd0/u4Ko9606	rogid:Xc4aPsHtdQKj02Q5cqqgw29pSS09606	intact-crc:A471A791F98D6D96|rigid:ygzwDYw72Kzyg+RFyCEBurCIvls	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43559	uniprotkb:P50552	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	intact:EBI-748201|uniprotkb:Q6PIZ1|uniprotkb:Q93035|uniprotkb:B2RBT9|intact:EBI-28992147|ensembl:ENSP00000245932	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:vasp_human(display_long)|uniprotkb:VASP(gene name)|psi-mi:VASP(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695468|imex:IM-22632-241	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	refseq:NP_003361.1|ensembl:ENSP00000245932|ensembl:ENSG00000125753(gene)|ensembl:ENST00000245932(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014885(VASP tetramerisation)|interpro:IPR017354(Vasodilator-stimulated phosphoprotein)|interpro:IPR034367|interpro:IPR038023|mint:P50552|rcsb pdb:1EGX|rcsb pdb:1JNG|rcsb pdb:1USD|rcsb pdb:1USE|rcsb pdb:2PAV|rcsb pdb:2PBD|rcsb pdb:3CHW|reactome:R-HSA-202433|reactome:R-HSA-376176|reactome:R-HSA-446353|dip:DIP-44105N|refseq:XM_005259199.1(identity)|entrezgene/locuslink:7408(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	rogid:G8ONp2lhbQKUCrDKnx8AMIKSNHA9606	intact-crc:7EE9C5B374356B3E|rigid:dD5sMtZ7vD/wK+/TA72WjCtkA+I	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46109	uniprotkb:O60496	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	intact:EBI-1046024|uniprotkb:Q8N5A4|ensembl:ENSP00000276420	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:dok2_human(display_long)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:DOK2(gene name)|psi-mi:DOK2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695498|imex:IM-22632-243	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|entrezgene/locuslink:1399(identity)|refseq:NM_005207.3(identity)	refseq:NP_003965.2|ensembl:ENSG00000147443(gene)|ensembl:ENST00000276420(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|rcsb pdb:2D9W|rcsb pdb:2DLW|reactome:R-HSA-210993|reactome:R-HSA-8853659|go:"GO:0007166"(cell surface receptor signaling pathway)|entrezgene/locuslink:9046(identity)|refseq:NM_003974.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:gBEpjlq3kc6oYF0uVqPz04hfrHw9606	intact-crc:98C6D975E33F7700|rigid:Nuqs70KfBVWr9ICs7aUzcCypyZY	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46109	uniprotkb:Q13191	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	intact:EBI-744027|uniprotkb:Q63Z43|uniprotkb:A8K9S7|uniprotkb:Q13192|uniprotkb:Q13193|uniprotkb:Q3LIC0|uniprotkb:Q8IVC5|uniprotkb:B7WNM4|intact:EBI-28969458|ensembl:ENSP00000377598|intact:EBI-8051403|intact:MINT-7907019	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:cblb_human(display_long)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695483|imex:IM-22632-242	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|entrezgene/locuslink:1399(identity)|refseq:NM_005207.3(identity)	refseq:NP_733762.2|refseq:NP_001308717.1|ensembl:ENSP00000377598|ensembl:ENST00000403724|ensembl:ENSP00000384816|ensembl:ENST00000405772|ensembl:ENSP00000384938|refseq:XP_011511559.1|ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q13191|rcsb pdb:2AK5|rcsb pdb:2BZ8|rcsb pdb:2DO6|rcsb pdb:2J6F|rcsb pdb:2JNH|rcsb pdb:2LDR|rcsb pdb:2OOA|rcsb pdb:2OOB|rcsb pdb:3PFV|rcsb pdb:3VGO|rcsb pdb:3ZNI|reactome:R-HSA-983168|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|dip:DIP-33091N|entrezgene/locuslink:868(identity)|refseq:NM_170662.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606	intact-crc:E25D116D69EE09F5|rigid:rbINobWATHyE+GffskCPt+EsR0M	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99704	uniprotkb:P46109	intact:EBI-1384360|uniprotkb:O43204|uniprotkb:Q53TY2|uniprotkb:Q9UHG6|ensembl:ENSP00000233668	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	psi-mi:dok1_human(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:pp62(gene name synonym)|uniprotkb:DOK1(gene name)|psi-mi:DOK1(display_short)	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695513|imex:IM-22632-244	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001184189.1|refseq:NP_001372.1|refseq:NP_001305797.1|ensembl:ENSG00000115325(gene)|ensembl:ENST00000233668(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:Q99704|rcsb pdb:2V76|reactome:R-HSA-8849469|reactome:R-HSA-8853659|refseq:NM_001381.3(identity)|entrezgene/locuslink:1796(identity)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|entrezgene/locuslink:1399(identity)|refseq:NM_005207.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Pvjez+wIa3gWdY9ZYvWN6lmOM4o9606	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	intact-crc:A683371387AD5B32|rigid:SvJ4njZUxhYuzvvqDwTDjfTHjsA	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13191	uniprotkb:P46108	intact:EBI-744027|uniprotkb:Q63Z43|uniprotkb:A8K9S7|uniprotkb:Q13192|uniprotkb:Q13193|uniprotkb:Q3LIC0|uniprotkb:Q8IVC5|uniprotkb:B7WNM4|intact:EBI-28969458|ensembl:ENSP00000377598|intact:EBI-8051403|intact:MINT-7907019	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:cblb_human(display_long)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695528|imex:IM-22632-245	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_733762.2|refseq:NP_001308717.1|ensembl:ENSP00000377598|ensembl:ENST00000403724|ensembl:ENSP00000384816|ensembl:ENST00000405772|ensembl:ENSP00000384938|refseq:XP_011511559.1|ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q13191|rcsb pdb:2AK5|rcsb pdb:2BZ8|rcsb pdb:2DO6|rcsb pdb:2J6F|rcsb pdb:2JNH|rcsb pdb:2LDR|rcsb pdb:2OOA|rcsb pdb:2OOB|rcsb pdb:3PFV|rcsb pdb:3VGO|rcsb pdb:3ZNI|reactome:R-HSA-983168|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|dip:DIP-33091N|entrezgene/locuslink:868(identity)|refseq:NM_170662.3(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:96A32F874FD263E2|rigid:D5/N28Npe7FEobUizB151kissYw	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42684-3	uniprotkb:P46108	intact:EBI-10693977|ensembl:ENSP00000423578	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:p42684-3(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym)|uniprotkb:1ALCTL(isoform synonym)|uniprotkb:IC(isoform synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695543|imex:IM-22632-246	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143322(gene)|ensembl:ENST00000512653(transcript)|intact:EBI-1102694(isoform-parent)|uniprotkb:P42684-3(isoform-parent)|refseq:NM_005158.4(identity)|entrezgene/locuslink:27(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:gLzqA1k71ptItAHexZD/6P1Ilos9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:794524637C27EADF|rigid:/ip1SzxNQ1pxbdjpijzxbYCKQE8	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42684-3	uniprotkb:P40763-2	intact:EBI-10693977|ensembl:ENSP00000423578	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:p42684-3(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym)|uniprotkb:1ALCTL(isoform synonym)|uniprotkb:IC(isoform synonym)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695558|imex:IM-22632-247	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143322(gene)|ensembl:ENST00000512653(transcript)|intact:EBI-1102694(isoform-parent)|uniprotkb:P42684-3(isoform-parent)|refseq:NM_005158.4(identity)|entrezgene/locuslink:27(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	-	isoform-comment:Contains a phosphotyrosine at position 704.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:gLzqA1k71ptItAHexZD/6P1Ilos9606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:52C3BCDED2066360|rigid:Q13Pfuptk8HvzJqunDmgFZ3MGG0	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43559	uniprotkb:P42679	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	intact:EBI-751664|uniprotkb:B3KNZ9|uniprotkb:Q9NST8|ensembl:ENSP00000308734	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:matk_human(display_long)|uniprotkb:Tyrosine-protein kinase CTK(gene name synonym)|uniprotkb:Protein kinase HYL(gene name synonym)|uniprotkb:Hematopoietic consensus tyrosine-lacking kinase(gene name synonym)|uniprotkb:MATK(gene name)|psi-mi:MATK(display_short)|uniprotkb:CTK(gene name synonym)|uniprotkb:HYL(gene name synonym)|uniprotkb:CSK homologous kinase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695573|imex:IM-22632-248	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	refseq:NP_002369.2|refseq:NP_647611.1|refseq:NP_647612.1|refseq:XP_011526320.1|ensembl:ENSG00000007264(gene)|ensembl:ENST00000310132(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1JWO|rcsb pdb:1X6G|rcsb pdb:3US4|reactome:R-HSA-8863795|entrezgene/locuslink:4145(identity)|refseq:NM_139355.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	rogid:zA5Bl6NIDDz31AJcm6u02v4bEe89606	intact-crc:6EE635002BC05FF9|rigid:GtZ7lYuxm5gyc3AtDZvfxEOCTgY	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:P41134	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-1215527|uniprotkb:O00651|uniprotkb:O00652|uniprotkb:Q16371|uniprotkb:Q16377|uniprotkb:Q5TE66|uniprotkb:Q5TE67|uniprotkb:Q969Z7|uniprotkb:Q9H0Z5|uniprotkb:Q9H109|uniprotkb:A8K537|uniprotkb:E1P5L4|ensembl:ENSP00000365280	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:id1_human(display_long)|uniprotkb:ID1(gene name)|psi-mi:ID1(display_short)|uniprotkb:ID(gene name synonym)|uniprotkb:Inhibitor of DNA binding 1(gene name synonym)|uniprotkb:BHLHB24(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 24(gene name synonym)|uniprotkb:Inhibitor of differentiation 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695588|imex:IM-22632-249	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	refseq:NP_002156.2|refseq:NP_851998.1|dip:DIP-38112N|ensembl:ENSG00000125968(gene)|ensembl:ENST00000376112(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010621"(negative regulation of transcription by transcription factor localization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036164"(cell-abiotic substrate adhesion)|go:"GO:0005654"(nucleoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070628"(proteasome binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901342"(regulation of vasculature development)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR026052|interpro:IPR036638|mint:P41134|reactome:R-HSA-2559585|reactome:R-HSA-9031628|entrezgene/locuslink:3397(identity)|refseq:NM_002165.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:IVXAJsAnQLB8hVutO0qX4bS8gXM9606	intact-crc:8A6932B40D8AF567|rigid:4RJMdf+mbm5pD7ZkujZSZDO2+SQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35219	uniprotkb:P40763	intact:EBI-718700|uniprotkb:Q32MY2|uniprotkb:A8K0A5|uniprotkb:B3KQZ7|ensembl:ENSP00000314407	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:cah8_human(display_long)|uniprotkb:Carbonic anhydrase VIII(gene name synonym)|uniprotkb:CA8(gene name)|psi-mi:CA8(display_short)|uniprotkb:CALS(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695603|imex:IM-22632-250	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004047.3|refseq:NP_001308766.1|refseq:NP_001308767.1|refseq:NP_001308768.1|ensembl:ENSG00000178538(gene)|ensembl:ENST00000317995(transcript)|go:"GO:0004089"(carbonate dehydratase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016836"(hydro-lyase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR001148(Carbonic anhydrase, eukaryotic)|interpro:IPR018338|interpro:IPR023561|interpro:IPR036398|interpro:IPR041877|rcsb pdb:2W2J|entrezgene/locuslink:767(identity)|refseq:NM_004056.4(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ExWihL00UgXcbYaCfzAXK8g5i5E9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:6E44FDD43B48E96B|rigid:F7itfEeXgkHY8FPNf5I+JCZY/TQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29372-4	uniprotkb:P46108	intact:EBI-10695618|ensembl:ENSP00000348809	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:p29372-4(display_long)|uniprotkb:MPG(gene name)|psi-mi:MPG(display_short)|uniprotkb:3-alkyladenine DNA glycosylase(gene name synonym)|uniprotkb:3-methyladenine DNA glycosidase(gene name synonym)|uniprotkb:AAG(gene name synonym)|uniprotkb:ADPG(gene name synonym)|uniprotkb:ANPG(gene name synonym)|uniprotkb:MID1(gene name synonym)|uniprotkb:N-methylpurine-DNA glycosylase(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695622|imex:IM-22632-251	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000103152(gene)|ensembl:ENST00000356432(transcript)|intact:EBI-1043398(isoform-parent)|uniprotkb:P29372-4(isoform-parent)|refseq:NM_001015052.2(identity)|entrezgene/locuslink:4350(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:aUWGFbqN9ptv1hvAmV6VMBjyaNA9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:8556167B3087DAE8|rigid:4AF2n1n2kBBknm6/WpH/lHaezAY	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27986-2	uniprotkb:P35568	intact:EBI-9090282|ensembl:ENSP00000338554	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695637|imex:IM-22632-252	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772|refseq:NM_005544.2(identity)|entrezgene/locuslink:3667(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FRK (P42685), FYN (P06241), PTK2 (Q05397), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	intact-crc:0E85E5B10AAF13BD|rigid:VQtrgiFLafp63gbkUkDVm2Cv+L8	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27986-2	uniprotkb:P22681	intact:EBI-9090282|ensembl:ENSP00000338554	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695652|imex:IM-22632-253	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FRK (P42685), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:7F1C2E5071007630|rigid:5skwRPabOlJ7FcNszPktdg6ROYM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27986-2	uniprotkb:O15524	intact:EBI-9090282|ensembl:ENSP00000338554	intact:EBI-968198|ensembl:ENSP00000329418|ensembl:ENSP00000496577|uniprotkb:O15097|uniprotkb:Q9NSA7	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:socs1_human(display_long)|uniprotkb:SOCS1(gene name)|psi-mi:SOCS1(display_short)|uniprotkb:SSI1(gene name synonym)|uniprotkb:TIP3(gene name synonym)|uniprotkb:JAK-binding protein(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 1(gene name synonym)|uniprotkb:Tec-interacting protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695667|imex:IM-22632-254	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	go:"GO:0043377"(negative regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010533"(regulation of activation of Janus kinase activity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR028411|interpro:IPR035861|interpro:IPR036036|interpro:IPR036860|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|mint:O15524|reactome:R-HSA-1266695|reactome:R-HSA-1433559|reactome:R-HSA-166058|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|ensembl:ENSG00000185338(gene)|ensembl:ENST00000332029(transcript)|ensembl:ENST00000644787(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|refseq:NP_003736.1|dip:DIP-29662N|entrezgene/locuslink:8651(identity)|refseq:NM_003745.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	rogid:Ybb6XvshFQp4GUNEiBZ41ff/H8I9606	intact-crc:79644B9DFAB8115D|rigid:YLiHNfo9dMsHp4TSjc5o3Mpvrqc	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27986-2	uniprotkb:P46108-2	intact:EBI-9090282|ensembl:ENSP00000338554	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695682|imex:IM-22632-255	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:37EFE439FD4C56A9|rigid:s3tiyX8t06ApN5WdS13y+eNkfcM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:P27986-2	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-9090282|ensembl:ENSP00000338554	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695697|imex:IM-22632-256	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	intact-crc:7571B1DC471C98A5|rigid:TiUTBgxDgF+0q1OycYUSE4V6BCA	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:P27986-2	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-9090282|ensembl:ENSP00000338554	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695712|imex:IM-22632-257	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	intact-crc:871B095C10272C4E|rigid:t3ITtvw+XlbxMKAMMEci+FyvNkg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:P27986-2	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-9090282|ensembl:ENSP00000338554	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695727|imex:IM-22632-258	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	intact-crc:CEDD940601AA491A|rigid:08gAcWchF1amVgDcetEj9So911A	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:P27986-2	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-9090282|ensembl:ENSP00000338554	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695742|imex:IM-22632-259	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	-	crc64:6C00632211C8012D	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	intact-crc:79E76E7D559173F2|rigid:JnThNIWbveuOpAq70IKPZzQx+zk	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:P27986-2	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-9090282|ensembl:ENSP00000338554	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695757|imex:IM-22632-260	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	intact-crc:EB1C6861680A3DBD|rigid:sMRMCkvSRdlQCrj4a+RhGjFZF7Y	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:Q92569	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695772|imex:IM-22632-261	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FRK (P42685), FYN (P06241), HCK (P08631), SRC (P12931), SYK (P43405), YES1 (P07947)."|figure legend:Suppl. table S3, suppl. Fig. S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:10D99BEFFD4852FF|rigid:H45MGP2sseKC/dza30HFhS26Qqg	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:P46108-2	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695787|imex:IM-22632-262	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:D2DBCD0C00348E45|rigid:tIx6Pb3N2s7eIFyFZyObLM7+nxI	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:P22681	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695802|imex:IM-22632-263	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:BC786F95FF532B2A|rigid:SdKd+YKNfmIFkiaT7TmjW1D2dRE	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:P22681	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695817|imex:IM-22632-264	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:6BE12FE052E4FA18|rigid:VKdbDqgrzNfCtF9qZ17lk9oBVR8	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:P40763	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695832|imex:IM-22632-265	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:EC9E28A016D8687E|rigid:koIn9JJX7tGbPUymbJ3oDIz2CNU	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:Q12929	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-375576|uniprotkb:A6NMC3|ensembl:ENSP00000281172|ensembl:ENSP00000441867|ensembl:ENSP00000442388|ensembl:ENSP00000494689|ensembl:ENSP00000494842|ensembl:ENSP00000495722|ensembl:ENSP00000495824|ensembl:ENSP00000495956|ensembl:ENSP00000496406|ensembl:ENSP00000496516|uniprotkb:Q8N6J0|uniprotkb:B4DX66|uniprotkb:A8K6W2|uniprotkb:A8KA66	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:eps8_human(display_long)|uniprotkb:EPS8(gene name)|psi-mi:EPS8(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695847|imex:IM-22632-266	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	ensembl:ENST00000645775(transcript)|ensembl:ENST00000646828(transcript)|ensembl:ENSG00000151491(gene)|ensembl:ENST00000646918(transcript)|ensembl:ENST00000647087(transcript)|ensembl:ENST00000647224(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010458"(exit from mitosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0030426"(growth cone)|go:"GO:0030832"(regulation of actin filament length)|go:"GO:0031267"(small GTPase binding)|ensembl:ENST00000281172(transcript)|ensembl:ENST00000543523(transcript)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|ensembl:ENST00000543612(transcript)|ensembl:ENST00000642278(transcript)|ensembl:ENST00000644374(transcript)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030222|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q12929|rcsb pdb:2E8M|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_004438.3|dip:DIP-32859N|entrezgene/locuslink:2059(identity)|refseq:NM_004447.5(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:ulBgb+4uZ7XrN4bLogRtd9I5AbY9606	intact-crc:8B09F4C162D41D71|rigid:MQJ654sQGRYXB5ENmRWtGAebZ3s	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:P42229	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-749537|uniprotkb:Q1KLZ6|ensembl:ENSP00000341208|ensembl:ENSP00000468749|ensembl:ENSP00000503262|ensembl:ENSP00000504449	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:sta5a_human(display_long)|uniprotkb:STAT5A(gene name)|psi-mi:STAT5A(display_short)|uniprotkb:STAT5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695862|imex:IM-22632-267	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	refseq:NP_003143.2|refseq:NP_001275647.1|refseq:NP_001275648.1|refseq:NP_001275649.1|dip:DIP-396N|ensembl:ENSG00000126561(gene)|ensembl:ENST00000345506(transcript)|ensembl:ENST00000590949(transcript)|ensembl:ENST00000676585(transcript)|ensembl:ENST00000677301(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42229|reactome:R-HSA-1170546|reactome:R-HSA-1251985|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772|refseq:NM_003152.3(identity)|entrezgene/locuslink:6776(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:KwM9uGM/He9Ome/Pzi6u/SgC6NY9606	intact-crc:9745312C0AD986BD|rigid:eMJKhgxaiYWwXmGBFh52gBiLD0U	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19419	uniprotkb:P46108	intact:EBI-726632|ensembl:ENSP00000247161|ensembl:ENSP00000366182|uniprotkb:O75606|uniprotkb:O95058|uniprotkb:Q969X8|uniprotkb:Q9UJM4|uniprotkb:B2R7H4	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:elk1_human(display_long)|uniprotkb:ELK1(gene name)|psi-mi:ELK1(display_short)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695877|imex:IM-22632-268	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000126767(gene)|ensembl:ENST00000247161(transcript)|ensembl:ENST00000376983(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|refseq:NP_001107595.1|refseq:NP_005220.2|refseq:NP_001244097.1|refseq:XP_016884828.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|mint:P19419|rcsb pdb:1DUX|rcsb pdb:5VVT|reactome:R-HSA-198753|reactome:R-HSA-9031628|reactome:R-HSA-9609690|reactome:R-HSA-9634638|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010467"(gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|dip:DIP-36057N|entrezgene/locuslink:2002(identity)|refseq:NM_005229.4(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:fhzXfUkfVKwHJ263gkK8USP+olg9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:45C419B88E92306C|rigid:8oc4RqlNYB6tL2MK7eWZRKF7Zps	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16885	uniprotkb:P19419	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	intact:EBI-726632|ensembl:ENSP00000247161|ensembl:ENSP00000366182|uniprotkb:O75606|uniprotkb:O95058|uniprotkb:Q969X8|uniprotkb:Q9UJM4|uniprotkb:B2R7H4	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:elk1_human(display_long)|uniprotkb:ELK1(gene name)|psi-mi:ELK1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695892|imex:IM-22632-269	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	ensembl:ENSG00000126767(gene)|ensembl:ENST00000247161(transcript)|ensembl:ENST00000376983(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|refseq:NP_001107595.1|refseq:NP_005220.2|refseq:NP_001244097.1|refseq:XP_016884828.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|mint:P19419|rcsb pdb:1DUX|rcsb pdb:5VVT|reactome:R-HSA-198753|reactome:R-HSA-9031628|reactome:R-HSA-9609690|reactome:R-HSA-9634638|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010467"(gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|dip:DIP-36057N|entrezgene/locuslink:2002(identity)|refseq:NM_005229.4(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	rogid:fhzXfUkfVKwHJ263gkK8USP+olg9606	intact-crc:0A5389F6DE46C1C7|rigid:WGA0biGQ89yaUD95BFbcWg88JLk	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60880	uniprotkb:P18847	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-712767|ensembl:ENSP00000344352|ensembl:ENSP00000355954|uniprotkb:Q5VTZ2|uniprotkb:Q6ICQ9|uniprotkb:Q7Z566|uniprotkb:Q8WYM6	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:atf3_human(display_long)|uniprotkb:Activating transcription factor 3(gene name synonym)|uniprotkb:ATF3(gene name)|psi-mi:ATF3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695907|imex:IM-22632-270	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N|entrezgene/locuslink:4068(identity)|refseq:NM_002351.4(identity)	ensembl:ENSG00000162772(gene)|ensembl:ENST00000341491(transcript)|ensembl:ENST00000366987(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061394"(regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990622"(CHOP-ATF3 complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029812|mint:P18847|reactome:R-HSA-380994|reactome:R-HSA-9633012|reactome:R-HSA-9648895|refseq:NP_001025458.1|refseq:NP_001665.1|refseq:XP_011507881.1|refseq:NP_001035709.1|refseq:NP_001193413.2|refseq:NP_001193415.1|refseq:NP_001193417.2|refseq:XP_005273203.1|dip:DIP-344N|entrezgene/locuslink:467(identity)|refseq:NM_001030287.3(identity)	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:4OpideXaQoVFi+x4P6iN5PG6RKY9606	intact-crc:9463BE57255A738B|rigid:VAFRXu0/zESlf5Xh6JnI7SPFAYM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17612	uniprotkb:P46108-2	intact:EBI-476586|uniprotkb:Q32P54|uniprotkb:Q9H2Y0|uniprotkb:Q9NRB4|uniprotkb:Q9NRH9|ensembl:ENSP00000309591|ensembl:ENSP00000499940	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:kapca_human(display_long)|uniprotkb:PRKACA(gene name)|psi-mi:PRKACA(display_short)|uniprotkb:PKACA(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695922|imex:IM-22632-271	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002721.1|refseq:NP_997401.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|ensembl:ENSG00000072062(gene)|ensembl:ENSG00000288516(gene)|ensembl:ENST00000308677(transcript)|ensembl:ENST00000673550(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:0046827"(positive regulation of protein export from nucleus)|rcsb pdb:5IZJ|rcsb pdb:5J5X|rcsb pdb:5N23|rcsb pdb:5UZK|rcsb pdb:6BYR|rcsb pdb:6BYS|rcsb pdb:6C0U|rcsb pdb:6FRX|rcsb pdb:6NO7|rcsb pdb:6QJ7|rcsb pdb:6WJF|rcsb pdb:6WJG|reactome:R-HSA-111931|reactome:R-HSA-163358|reactome:R-HSA-163560|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-2565942|reactome:R-HSA-380259|rcsb pdb:3MVJ|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3NX8|interpro:IPR044109|rcsb pdb:3OOG|rcsb pdb:3OVV|rcsb pdb:3OWP|rcsb pdb:3OXT|rcsb pdb:3P0M|mint:P17612|rcsb pdb:3POO|rcsb pdb:3VQH|rcsb pdb:4AE6|rcsb pdb:2GU8|rcsb pdb:4AE9|rcsb pdb:4UJ1|rcsb pdb:4UJ2|rcsb pdb:3AGL|rcsb pdb:3AGM|rcsb pdb:3AMA|rcsb pdb:3AMB|rcsb pdb:4UJ9|rcsb pdb:4UJA|rcsb pdb:4UJB|rcsb pdb:4WB5|rcsb pdb:4WB6|rcsb pdb:4WB7|rcsb pdb:3L9L|rcsb pdb:3L9M|rcsb pdb:3L9N|rcsb pdb:4WB8|rcsb pdb:5BX6|rcsb pdb:5BX7|rcsb pdb:5IZF|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|reactome:R-HSA-432040|reactome:R-HSA-4420097|reactome:R-HSA-442720|reactome:R-HSA-512988|reactome:R-HSA-5578775|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5620912|reactome:R-HSA-5621575|reactome:R-HSA-5687128|reactome:R-HSA-8853659|reactome:R-HSA-8854518|reactome:R-HSA-380320|reactome:R-HSA-8963896|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9634600|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|reactome:R-HSA-9010642|refseq:NP_001291278.1|dip:DIP-33878N|entrezgene/locuslink:5566(identity)|refseq:NM_002730.3(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:7yhAi67qjSKPIff2dwqjScPXEYM9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:9CF40C2972A13ECA|rigid:i7WfWW0E9HOfBiK7qn8elkTajSw	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16885	uniprotkb:P10809	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695937|imex:IM-22632-272	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N|refseq:NM_199440.1(identity)|entrezgene/locuslink:3329(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606	intact-crc:FC240E9B6FB888B2|rigid:Yj/DuYAgyAxO1bGR9fTJ74wj1xA	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:P06400	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695952|imex:IM-22632-273	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N|entrezgene/locuslink:5925(identity)|refseq:NM_000321.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), YES1 (P07947)."|comment:"The interaction failed to show if kinase-dead versions of ABL2 (P42684) or FYN (P06241) were used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:xidCNX96KlQzu160polvT61k4Zw9606	intact-crc:0B92AB8B1265E9F7|rigid:KAHMJQFt20oWWb7C6Rd4QnhRCGQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5R372-2	uniprotkb:P06400	intact:EBI-10692254|ensembl:ENSP00000350027	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695968|imex:IM-22632-274	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N|entrezgene/locuslink:5925(identity)|refseq:NM_000321.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FER (P16591), FGR (P09769), FYN (P06241)."|comment:"The interaction failed to show if kinase-dead versions of ABL2 (P42684) or FYN (P06241) were used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	rogid:xidCNX96KlQzu160polvT61k4Zw9606	intact-crc:B12626F0E6172E78|rigid:rItiw7r6VPouBCqUozMppL0AlBc	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60496	uniprotkb:P06239	intact:EBI-1046024|uniprotkb:Q8N5A4|ensembl:ENSP00000276420	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	psi-mi:dok2_human(display_long)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:DOK2(gene name)|psi-mi:DOK2(display_short)	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695984|imex:IM-22632-275	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003965.2|ensembl:ENSG00000147443(gene)|ensembl:ENST00000276420(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|rcsb pdb:2D9W|rcsb pdb:2DLW|reactome:R-HSA-210993|reactome:R-HSA-8853659|go:"GO:0007166"(cell surface receptor signaling pathway)|entrezgene/locuslink:9046(identity)|refseq:NM_003974.2(identity)	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374|entrezgene/locuslink:3932(identity)|refseq:NM_001042771.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:gBEpjlq3kc6oYF0uVqPz04hfrHw9606	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	intact-crc:7D0D5AA379060E7B|rigid:SE5MxwOgB5wzkVaQSvctPJM6fpo	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06239	uniprotkb:P40763-2	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10695999|imex:IM-22632-276	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374|entrezgene/locuslink:3932(identity)|refseq:NM_001042771.2(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	-	isoform-comment:Contains a phosphotyrosine at position 704.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:416876D5D939D080|rigid:Nb9U55YUPEJON4LMX/zsrU+61J8	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16885	uniprotkb:P04637	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696014|imex:IM-22632-277	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|refseq:NM_001126112.2(identity)|entrezgene/locuslink:7157(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FRK (P42685), FYN (P06241), SYK (P43405)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	intact-crc:73DD705834D3BB7A|rigid:XtXhHedHtoSV13uWpyWyeVaPYAQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95997	uniprotkb:P16885	intact:EBI-2551072|ensembl:ENSP00000344936|ensembl:ENSP00000377536|ensembl:ENSP00000430642	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	psi-mi:pttg1_human(display_long)|uniprotkb:EAP1(gene name synonym)|uniprotkb:PTTG(gene name synonym)|uniprotkb:TUTR1(gene name synonym)|uniprotkb:Pituitary tumor-transforming gene 1 protein(gene name synonym)|uniprotkb:Esp1-associated protein(gene name synonym)|uniprotkb:PTTG1(gene name)|psi-mi:PTTG1(display_short)	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696029|imex:IM-22632-278	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164611(gene)|ensembl:ENST00000352433(transcript)|ensembl:ENST00000393964(transcript)|ensembl:ENST00000520452(transcript)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007283"(spermatogenesis)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:2000816"(negative regulation of mitotic sister chromatid separation)|interpro:IPR006940(Securin sister-chromatid separation inhibitor)|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-2467813|refseq:NP_004210.1|refseq:NP_001269311.1|refseq:NP_001269312.1|dip:DIP-56460N|entrezgene/locuslink:9232(identity)|refseq:NM_004219.3(identity)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FES (P07332), PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:CsVFdecK6rCfJkLuzlnvom1nsB89606	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	intact-crc:5372E053B188F686|rigid:2h5MK8GaYSgX3seyMhXUwjXt0mI	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:O95073-2	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-10696047	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:o95073-2(display_long)|uniprotkb:FSBP(gene name)|psi-mi:FSBP(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696044|imex:IM-22632-279	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	intact:EBI-1059030(isoform-parent)|uniprotkb:O95073-2(isoform-parent)|refseq:NM_001256141.1(identity)|entrezgene/locuslink:25788(identity)	-	-	isoform-comment:No experimental confirmation available.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3, suppl. fig. S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:j4ktleFZa7rAjRFENAKAGdAd+Fs9606	intact-crc:10C3189D53323C84|rigid:Lde1jqg/PztZOpetnIF4yx2YKwU	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75829-2	uniprotkb:Q8WXH5	intact:EBI-10696063|ensembl:ENSP00000388576	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	psi-mi:o75829-2(display_long)|uniprotkb:MYETS1(gene name synonym)|uniprotkb:CNMD(gene name)|psi-mi:CNMD(display_short)|uniprotkb:CHMI(gene name synonym)|uniprotkb:Chondromodulin(gene name synonym)|uniprotkb:LECT1(gene name synonym)	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696067|imex:IM-22632-280	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1220187(isoform-parent)|uniprotkb:O75829-2(isoform-parent)|ensembl:ENSG00000136110(gene)|ensembl:ENST00000448904(transcript)|refseq:NM_001011705.1(identity)|entrezgene/locuslink:11061(identity)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	-	isoform-comment:No experimental confirmation available.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3, suppl. fig. S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:PFYeXYbyIK2gv+GHHQBqfAR2Erg9606	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	intact-crc:37584315A4174F74|rigid:fV8WW25CLtHsKimCHDPmYvly17k	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96JZ2	uniprotkb:O75829-2	intact:EBI-3919324|intact:EBI-28973686|ensembl:ENSP00000482604|ensembl:ENSP00000483354|uniprotkb:B5ME72|uniprotkb:Q6ZNG7	intact:EBI-10696063|ensembl:ENSP00000388576	psi-mi:hsh2d_human(display_long)|uniprotkb:HSH2D(gene name)|psi-mi:HSH2D(display_short)|uniprotkb:ALX(gene name synonym)|uniprotkb:Adaptor in lymphocytes of unknown function X(gene name synonym)	psi-mi:o75829-2(display_long)|uniprotkb:MYETS1(gene name synonym)|uniprotkb:CNMD(gene name)|psi-mi:CNMD(display_short)|uniprotkb:CHMI(gene name synonym)|uniprotkb:Chondromodulin(gene name synonym)|uniprotkb:LECT1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696082|imex:IM-22632-281	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000483354|ensembl:ENSP00000482604|ensembl:ENSG00000196684(gene)|ensembl:ENST00000613986(transcript)|ensembl:ENST00000616645(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR035047|interpro:IPR036860|rcsb pdb:2CS0|go:"GO:0005737"(cytoplasm)|refseq:NP_116244.1|refseq:NP_001278203.1|refseq:NM_032855.3(identity)|entrezgene/locuslink:84941(identity)	intact:EBI-1220187(isoform-parent)|uniprotkb:O75829-2(isoform-parent)|ensembl:ENSG00000136110(gene)|ensembl:ENST00000448904(transcript)|refseq:NM_001011705.1(identity)|entrezgene/locuslink:11061(identity)	-	-	isoform-comment:No experimental confirmation available.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3, suppl. fig. S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Y01YjkfU/oOtbz2TdQcnm+lBWhs9606	rogid:PFYeXYbyIK2gv+GHHQBqfAR2Erg9606	intact-crc:44EA6D6FE0FDC0CF|rigid:G11YnBLUkEbhF85LbcLa/yN5E08	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35568	uniprotkb:O75815	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	intact:EBI-702336|uniprotkb:Q6UW40|uniprotkb:Q9BR50|uniprotkb:D3DT43|uniprotkb:Q5TEW3|ensembl:ENSP00000260502|ensembl:ENSP00000359263|ensembl:ENSP00000359264	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:bcar3_human(display_long)|uniprotkb:SH2 domain-containing protein 3B(gene name synonym)|uniprotkb:Novel SH2-containing protein 2(gene name synonym)|uniprotkb:BCAR3(gene name)|psi-mi:BCAR3(display_short)|uniprotkb:NSP2(gene name synonym)|uniprotkb:SH2D3B(gene name synonym)|uniprotkb:UNQ271/PRO308(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696097|imex:IM-22632-282	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772|refseq:NM_005544.2(identity)|entrezgene/locuslink:3667(identity)	refseq:NP_003558.1|refseq:NP_001248339.1|refseq:NP_001295180.1|refseq:NP_001248337.1|refseq:NP_001248338.1|refseq:XP_016857969.1|dip:DIP-33857N|ensembl:ENSG00000137936(gene)|ensembl:ENST00000260502(transcript)|ensembl:ENST00000370243(transcript)|ensembl:ENST00000370244(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042493"|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0086100"(endothelin receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR023578|interpro:IPR028849|interpro:IPR036860|interpro:IPR036964|interpro:IPR044102|mint:O75815|rcsb pdb:3T6A|refseq:NM_003567.3(identity)|entrezgene/locuslink:8412(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FRK (P42685), FYN (P06241), HCK (P08631), LYN (P07948), PTK2 (Q05397), SRC (P12931), TNK1 (Q13470), YES1 (P07947)."|comment:"The interaction failed to show if kinase-dead versions of FYN (P06241), ABL2 (P42684), FRK (P42685), PTK2 (Q05397) or TNK1 (Q13470) were used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	rogid:r4mh2ZDGa0AleYRBV+oAiDds1+w9606	intact-crc:E1D1E011CD9F7F64|rigid:hXY4VdfEmUyftOI+vwotwWGjjWM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75604-3	uniprotkb:Q92569	intact:EBI-10696113|ensembl:ENSP00000407842	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:o75604-3(display_long)|uniprotkb:USP2(gene name)|psi-mi:USP2(display_short)|uniprotkb:41 kDa ubiquitin-specific protease(gene name synonym)|uniprotkb:Deubiquitinating enzyme 2(gene name synonym)|uniprotkb:UBP41(gene name synonym)|uniprotkb:Ubiquitin thioesterase 2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 2(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696117|imex:IM-22632-283	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000036672(gene)|ensembl:ENST00000455332(transcript)|intact:EBI-743272(isoform-parent)|uniprotkb:O75604-3(isoform-parent)|entrezgene/locuslink:9099(identity)|refseq:NM_001243759.1(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	isoform-comment:"Ref.7 (AAH41366) sequence is in conflict in position: 10:Y->S."	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FES (P07332), FYN (P06241), JAK2 (O60674), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Ho6ANsxAKd9TWFf8Uw5IRSMMGs49606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:770187F6444AA893|rigid:ejx2+BgKAcrwsizCIApo7MqJTts	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:O75208	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-724524|uniprotkb:Q7L5V7|uniprotkb:Q7Z5T6|uniprotkb:Q8NBL4|uniprotkb:Q9NTJ2|uniprotkb:Q9P056|uniprotkb:A8K3L2|ensembl:ENSP00000262507	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:coq9_human(display_long)|uniprotkb:COQ9(gene name)|psi-mi:COQ9(display_short)|uniprotkb:C16orf49(gene name synonym)|uniprotkb:HSPC326(orf name)|uniprotkb:PSEC0129(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696147|imex:IM-22632-285	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	refseq:NP_064708.1|ensembl:ENSG00000088682(gene)|ensembl:ENST00000262507(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006744"(ubiquinone biosynthetic process)|go:"GO:0008289"(lipid binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR012762(Ubiquinone biosynthesis protein COQ9)|interpro:IPR013718(COQ9)|rcsb pdb:4RHP|rcsb pdb:6AWL|rcsb pdb:6DEW|reactome:R-HSA-2142789|entrezgene/locuslink:57017(identity)|refseq:NM_020312.3(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:Jsv3JHc6FiNNH18LONTL34OsHoE9606	intact-crc:3E6F5504F4EED433|rigid:e7oJ15jZJBA4rXg8lxaliiS6FaQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75461	uniprotkb:Q92569	intact:EBI-749694|uniprotkb:O60544|uniprotkb:Q53QY9|uniprotkb:Q7Z2H6|uniprotkb:A8K2Z8|uniprotkb:G5E936|uniprotkb:Q6Q9Z6|ensembl:ENSP00000370936	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:e2f6_human(display_long)|uniprotkb:E2F6(gene name)|psi-mi:E2F6(display_short)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696132|imex:IM-22632-284	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001265204.1|refseq:NP_001265205.1|refseq:NP_001265206.1|refseq:NP_001265207.1|refseq:NP_937987.2|dip:DIP-41699N|ensembl:ENSG00000169016(gene)|ensembl:ENST00000381525(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR015635(Transcription Factor E2F6)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:O75461|reactome:R-HSA-69205|reactome:R-HSA-8953750|interpro:IPR032198|refseq:NM_198256.3(identity)|entrezgene/locuslink:1876(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:HZpQSfeASNNMLz4NCYOp6T0yXTk9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:51D31B16F9B1F193|rigid:ePAXXvE202j4UX4xvh55+D4sfxM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60880	uniprotkb:P16333	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-389883|uniprotkb:B7Z751|ensembl:ENSP00000288986|ensembl:ENSP00000417273|intact:EBI-3448658|uniprotkb:D3DNE3	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:nck1_human(display_long)|uniprotkb:NCK1(gene name)|psi-mi:NCK1(display_short)|uniprotkb:NCK(gene name synonym)|uniprotkb:NCK adaptor protein 1(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696162|imex:IM-22632-286	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N|entrezgene/locuslink:4068(identity)|refseq:NM_002351.4(identity)	refseq:NP_001278928.1|ensembl:ENSG00000158092(gene)|ensembl:ENST00000288986(transcript)|ensembl:ENST00000481752(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007172"(signal complex assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|refseq:NP_001177725.1|refseq:NP_006144.1|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|mint:P16333|rcsb pdb:2CI8|rcsb pdb:2CI9|rcsb pdb:2CUB|rcsb pdb:2JS0|rcsb pdb:2JS2|rcsb pdb:2JW4|rcsb pdb:5QU1|rcsb pdb:5QU2|rcsb pdb:5QU3|rcsb pdb:5QU4|rcsb pdb:5QU5|rcsb pdb:5QU6|rcsb pdb:5QU7|rcsb pdb:5QU8|rcsb pdb:5QUA|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-373753|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9664422|reactome:R-HSA-983695|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|dip:DIP-639N|entrezgene/locuslink:4690(identity)|refseq:NM_006153.5(identity)	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), LYN (P07948), SRC (P12931)."|comment:"The interaction failed to show if a kinase-dead version of FYN (P06241) was used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:UzgLYRQQ9VjN7eKkgn76At/7cSA9606	intact-crc:2A4200DF1DBA9EA6|rigid:2LU/1kY/ivBbNIJ4poGRF9DS45U	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60636	uniprotkb:P62993	intact:EBI-3914288|uniprotkb:Q8WU05|uniprotkb:Q5TET2|ensembl:ENSP00000358529|uniprotkb:D6PTH4	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:tsn2_human(display_long)|uniprotkb:TSPAN2(gene name)|psi-mi:TSPAN2(display_short)|uniprotkb:Tetraspan NET-3(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696178|imex:IM-22632-287	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001295245.1|refseq:NP_005716.2|ensembl:ENSG00000134198(gene)|ensembl:ENST00000369516(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014005"(microglia development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042552"(myelination)|go:"GO:0043209"(myelin sheath)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061564"(axon development)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|refseq:NM_005725.4(identity)|entrezgene/locuslink:10100(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), PTK2 (Q05397), TNK1 (Q13470), YES1 (P07947)."|comment:"The interaction failed to show if kinase-dead versions of ABL2 (P42684) or FYN (P06241) were used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:aAvB/0QxH0/5YF5dkbBh5wpz3uw9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:F66C5ADF9A5C9AF4|rigid:G4awIUPqy2QhVyRj9zHTAk2jFhw	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:O60496	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-1046024|uniprotkb:Q8N5A4|ensembl:ENSP00000276420	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:dok2_human(display_long)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:DOK2(gene name)|psi-mi:DOK2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696209|imex:IM-22632-289	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_003965.2|ensembl:ENSG00000147443(gene)|ensembl:ENST00000276420(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|rcsb pdb:2D9W|rcsb pdb:2DLW|reactome:R-HSA-210993|reactome:R-HSA-8853659|go:"GO:0007166"(cell surface receptor signaling pathway)|entrezgene/locuslink:9046(identity)|refseq:NM_003974.2(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:gBEpjlq3kc6oYF0uVqPz04hfrHw9606	intact-crc:04DFB432BE8715A0|rigid:CY8HkDI6y2dsPrkA/u8DGDiITBA	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60636	uniprotkb:Q5R372-2	intact:EBI-3914288|uniprotkb:Q8WU05|uniprotkb:Q5TET2|ensembl:ENSP00000358529|uniprotkb:D6PTH4	intact:EBI-10692254|ensembl:ENSP00000350027	psi-mi:tsn2_human(display_long)|uniprotkb:TSPAN2(gene name)|psi-mi:TSPAN2(display_short)|uniprotkb:Tetraspan NET-3(gene name synonym)	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696194|imex:IM-22632-288	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001295245.1|refseq:NP_005716.2|ensembl:ENSG00000134198(gene)|ensembl:ENST00000369516(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014005"(microglia development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042552"(myelination)|go:"GO:0043209"(myelin sheath)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061564"(axon development)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|refseq:NM_005725.4(identity)|entrezgene/locuslink:10100(identity)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FES (P07332)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:aAvB/0QxH0/5YF5dkbBh5wpz3uw9606	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	intact-crc:B60A555FDF6FF665|rigid:KWp7TGc59bx/LNcNIiafvHie/H8	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763-2	uniprotkb:O60496	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	intact:EBI-1046024|uniprotkb:Q8N5A4|ensembl:ENSP00000276420	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:dok2_human(display_long)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:DOK2(gene name)|psi-mi:DOK2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696239|imex:IM-22632-291	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_003965.2|ensembl:ENSG00000147443(gene)|ensembl:ENST00000276420(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|rcsb pdb:2D9W|rcsb pdb:2DLW|reactome:R-HSA-210993|reactome:R-HSA-8853659|go:"GO:0007166"(cell surface receptor signaling pathway)|entrezgene/locuslink:9046(identity)|refseq:NM_003974.2(identity)	-	isoform-comment:Contains a phosphotyrosine at position 704.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	rogid:gBEpjlq3kc6oYF0uVqPz04hfrHw9606	intact-crc:FF79C209053919F3|rigid:a5w5MlMI/c0o+Ia1fcHu0ZPytl8	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60496	uniprotkb:P46108	intact:EBI-1046024|uniprotkb:Q8N5A4|ensembl:ENSP00000276420	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:dok2_human(display_long)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:DOK2(gene name)|psi-mi:DOK2(display_short)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696224|imex:IM-22632-290	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003965.2|ensembl:ENSG00000147443(gene)|ensembl:ENST00000276420(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|rcsb pdb:2D9W|rcsb pdb:2DLW|reactome:R-HSA-210993|reactome:R-HSA-8853659|go:"GO:0007166"(cell surface receptor signaling pathway)|entrezgene/locuslink:9046(identity)|refseq:NM_003974.2(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:gBEpjlq3kc6oYF0uVqPz04hfrHw9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:AA2EA7C45ABC0EE4|rigid:bOlLVyMhyXebaRJGsP86+Ia/C2U	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60496	uniprotkb:Q9UKG1	intact:EBI-1046024|uniprotkb:Q8N5A4|ensembl:ENSP00000276420	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:dok2_human(display_long)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:DOK2(gene name)|psi-mi:DOK2(display_short)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696254|imex:IM-22632-292	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003965.2|ensembl:ENSG00000147443(gene)|ensembl:ENST00000276420(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|rcsb pdb:2D9W|rcsb pdb:2DLW|reactome:R-HSA-210993|reactome:R-HSA-8853659|go:"GO:0007166"(cell surface receptor signaling pathway)|entrezgene/locuslink:9046(identity)|refseq:NM_003974.2(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:gBEpjlq3kc6oYF0uVqPz04hfrHw9606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:BE0A1E86F351A2EA|rigid:7K8FYS/QKPqxV1E436fEtAMQBVM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60880	uniprotkb:O43257	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-347522|uniprotkb:Q6IB12|ensembl:ENSP00000304593	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:znhi1_human(display_long)|uniprotkb:Cyclin-G1-binding protein 1(gene name synonym)|uniprotkb:Zinc finger protein subfamily 4A member 1(gene name synonym)|uniprotkb:p18 Hamlet(gene name synonym)|uniprotkb:ZNHIT1(gene name)|psi-mi:ZNHIT1(display_short)|uniprotkb:CGBP1(gene name synonym)|uniprotkb:ZNFN4A1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696269|imex:IM-22632-293	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N|entrezgene/locuslink:4068(identity)|refseq:NM_002351.4(identity)	refseq:NP_006340.1|ensembl:ENSG00000106400(gene)|ensembl:ENST00000305105(transcript)|go:"GO:0000812"(Swr1 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031491"(nucleosome binding)|go:"GO:0043486"(histone exchange)|go:"GO:0046872"(metal ion binding)|interpro:IPR007529(Zinc finger, HIT-type)|interpro:IPR039723|mint:O43257|entrezgene/locuslink:10467(identity)|refseq:NM_006349.2(identity)	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631)."|comment:"The interaction failed to show if kinase-dead versions of ABL2 (P42684) or FYN (P06241) were used."|figure legend:Suppl. table S3, suppl .fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:Q7J5KSTTPql/B3mtDg1xvX0EWjw9606	intact-crc:32755285818AEFAA|rigid:eIuFL/bOejYNc33Z2igOvRa9oNM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14451	uniprotkb:O43257	intact:EBI-970191|ensembl:ENSP00000310771|ensembl:ENSP00000377759|ensembl:ENSP00000377761|uniprotkb:B2RAV1|uniprotkb:B3KNL0|uniprotkb:B3KWP9|uniprotkb:B7WP75|uniprotkb:Q53YD3|uniprotkb:Q9Y220|uniprotkb:Q92568|uniprotkb:Q96DF9|intact:EBI-1257061|uniprotkb:J3KQM4	intact:EBI-347522|uniprotkb:Q6IB12|ensembl:ENSP00000304593	psi-mi:grb7_human(display_long)|uniprotkb:GRB7(gene name)|psi-mi:GRB7(display_short)|uniprotkb:GRB7 adapter protein(gene name synonym)|uniprotkb:Epidermal growth factor receptor GRB-7(gene name synonym)|uniprotkb:B47(gene name synonym)	psi-mi:znhi1_human(display_long)|uniprotkb:Cyclin-G1-binding protein 1(gene name synonym)|uniprotkb:Zinc finger protein subfamily 4A member 1(gene name synonym)|uniprotkb:p18 Hamlet(gene name synonym)|uniprotkb:ZNHIT1(gene name)|psi-mi:ZNHIT1(display_short)|uniprotkb:CGBP1(gene name synonym)|uniprotkb:ZNFN4A1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696285|imex:IM-22632-294	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141738(gene)|ensembl:ENST00000309156(transcript)|ensembl:ENST00000394209(transcript)|ensembl:ENST00000394211(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042995"(cell projection)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035032|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q14451|rcsb pdb:1MW4|rcsb pdb:1WGR|rcsb pdb:2L4K|rcsb pdb:2QMS|rcsb pdb:3PQZ|rcsb pdb:4WWQ|rcsb pdb:4X6S|rcsb pdb:5D0J|rcsb pdb:5EEL|rcsb pdb:5EEQ|rcsb pdb:5TYI|rcsb pdb:5U06|rcsb pdb:5U1Q|go:"GO:0042802"(identical protein binding)|reactome:R-HSA-1306955|reactome:R-HSA-186763|reactome:R-HSA-210993|reactome:R-HSA-8853659|reactome:R-HSA-9696273|reactome:R-HSA-1433557|refseq:NP_001025173.1|refseq:NP_001229371.1|refseq:NP_001229372.1|refseq:NP_005301.2|refseq:NP_001317136.1|dip:DIP-502N|entrezgene/locuslink:2886(identity)|refseq:NM_001030002.2(identity)	refseq:NP_006340.1|ensembl:ENSG00000106400(gene)|ensembl:ENST00000305105(transcript)|go:"GO:0000812"(Swr1 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031491"(nucleosome binding)|go:"GO:0043486"(histone exchange)|go:"GO:0046872"(metal ion binding)|interpro:IPR007529(Zinc finger, HIT-type)|interpro:IPR039723|mint:O43257|entrezgene/locuslink:10467(identity)|refseq:NM_006349.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FRK (P42685), SYK (P43405)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:XViWZjk5YwdZFTG3zs2aNdxeFVQ9606	rogid:Q7J5KSTTPql/B3mtDg1xvX0EWjw9606	intact-crc:BD52B452C86CA77C|rigid:cVBPfxDQOjlyGhpZiDe7HOkod24	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43257	uniprotkb:Q9UN19	intact:EBI-347522|uniprotkb:Q6IB12|ensembl:ENSP00000304593	intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602	psi-mi:znhi1_human(display_long)|uniprotkb:Cyclin-G1-binding protein 1(gene name synonym)|uniprotkb:Zinc finger protein subfamily 4A member 1(gene name synonym)|uniprotkb:p18 Hamlet(gene name synonym)|uniprotkb:ZNHIT1(gene name)|psi-mi:ZNHIT1(display_short)|uniprotkb:CGBP1(gene name synonym)|uniprotkb:ZNFN4A1(gene name synonym)	psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696300|imex:IM-22632-295	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006340.1|ensembl:ENSG00000106400(gene)|ensembl:ENST00000305105(transcript)|go:"GO:0000812"(Swr1 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031491"(nucleosome binding)|go:"GO:0043486"(histone exchange)|go:"GO:0046872"(metal ion binding)|interpro:IPR007529(Zinc finger, HIT-type)|interpro:IPR039723|mint:O43257|entrezgene/locuslink:10467(identity)|refseq:NM_006349.2(identity)	refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695|entrezgene/locuslink:27071(identity)|refseq:NM_014395.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Q7J5KSTTPql/B3mtDg1xvX0EWjw9606	rogid:YYI49xKbndaB1MfL/QEovp2BF009606	intact-crc:8AC87CC3BFF2EF52|rigid:0zzKsS7/Cf8oVbiqls8xhjPkdno	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15524	uniprotkb:P46109	intact:EBI-968198|ensembl:ENSP00000329418|ensembl:ENSP00000496577|uniprotkb:O15097|uniprotkb:Q9NSA7	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	psi-mi:socs1_human(display_long)|uniprotkb:SOCS1(gene name)|psi-mi:SOCS1(display_short)|uniprotkb:SSI1(gene name synonym)|uniprotkb:TIP3(gene name synonym)|uniprotkb:JAK-binding protein(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 1(gene name synonym)|uniprotkb:Tec-interacting protein 3(gene name synonym)	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696315|imex:IM-22632-296	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0043377"(negative regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010533"(regulation of activation of Janus kinase activity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR028411|interpro:IPR035861|interpro:IPR036036|interpro:IPR036860|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|mint:O15524|reactome:R-HSA-1266695|reactome:R-HSA-1433559|reactome:R-HSA-166058|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|ensembl:ENSG00000185338(gene)|ensembl:ENST00000332029(transcript)|ensembl:ENST00000644787(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|refseq:NP_003736.1|dip:DIP-29662N|entrezgene/locuslink:8651(identity)|refseq:NM_003745.1(identity)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|entrezgene/locuslink:1399(identity)|refseq:NM_005207.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Ybb6XvshFQp4GUNEiBZ41ff/H8I9606	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	intact-crc:CEAD4E35341B6D99|rigid:ZWLwANzLCSZ80ZhC/Y/hWE4cjSQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15273	uniprotkb:P46108-2	intact:EBI-954089|ensembl:ENSP00000312624|uniprotkb:Q96L27	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:telt_human(display_long)|uniprotkb:Titin cap protein(gene name synonym)|uniprotkb:TCAP(gene name)|psi-mi:TCAP(display_short)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696345|imex:IM-22632-298	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173991(gene)|ensembl:ENST00000309889(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005829"(cytosol)|go:"GO:0007512"(adult heart development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0031432"(titin binding)|go:"GO:0031674"(I band)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036122"(BMP binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051373"(FATZ binding)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070080"(titin Z domain binding)|interpro:IPR015667(Telethonin)|interpro:IPR023111|mint:O15273|rcsb pdb:1YA5|rcsb pdb:2F8V|reactome:R-HSA-390522|refseq:NP_003664.1|dip:DIP-35730N|entrezgene/locuslink:8557(identity)|refseq:NM_003673.3(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:2Dfb7mWswRzoRh/YwYCWfzfTEu09606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:71966C1B31C7681E|rigid:WqMVsnfzi5Bgn3g2IYjW23UGFFY	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15524	uniprotkb:P46108-2	intact:EBI-968198|ensembl:ENSP00000329418|ensembl:ENSP00000496577|uniprotkb:O15097|uniprotkb:Q9NSA7	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:socs1_human(display_long)|uniprotkb:SOCS1(gene name)|psi-mi:SOCS1(display_short)|uniprotkb:SSI1(gene name synonym)|uniprotkb:TIP3(gene name synonym)|uniprotkb:JAK-binding protein(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 1(gene name synonym)|uniprotkb:Tec-interacting protein 3(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696330|imex:IM-22632-297	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0043377"(negative regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010533"(regulation of activation of Janus kinase activity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR028411|interpro:IPR035861|interpro:IPR036036|interpro:IPR036860|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|mint:O15524|reactome:R-HSA-1266695|reactome:R-HSA-1433559|reactome:R-HSA-166058|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|ensembl:ENSG00000185338(gene)|ensembl:ENST00000332029(transcript)|ensembl:ENST00000644787(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|refseq:NP_003736.1|dip:DIP-29662N|entrezgene/locuslink:8651(identity)|refseq:NM_003745.1(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Ybb6XvshFQp4GUNEiBZ41ff/H8I9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:3AC66A7BE9E9F5E3|rigid:U9EdHuhfDXQEYU3QUEbROzECAKQ	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15205	uniprotkb:Q13387	intact:EBI-6657186|ensembl:ENSP00000366249|ensembl:ENSP00000373039|ensembl:ENSP00000396152|ensembl:ENSP00000410416|uniprotkb:Q96EC7|uniprotkb:Q5STL2|uniprotkb:B0UZT6|uniprotkb:Q5SUK2	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:ubd_human(display_long)|uniprotkb:UBD(gene name)|psi-mi:UBD(display_short)|uniprotkb:Diubiquitin(gene name synonym)|uniprotkb:FAT10(gene name synonym)|uniprotkb:Ubiquitin-like protein FAT10(gene name synonym)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696360|imex:IM-22632-299	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000231968(gene)|ensembl:ENST00000377050(transcript)|ensembl:ENST00000383547(transcript)|ensembl:ENST00000421519(transcript)|ensembl:ENST00000432676(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016235"(aggresome)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|ensembl:ENSG00000206468(gene)|ensembl:ENSG00000213886(gene)|ensembl:ENSG00000228913(gene)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0070628"(proteasome binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|interpro:IPR042969|rcsb pdb:2MBE|rcsb pdb:6GF1|rcsb pdb:6GF2|reactome:R-HSA-8951664|refseq:NP_006389.2|entrezgene/locuslink:10537(identity)|refseq:NM_006398.3(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), JAK2 (O60674), PTK2 (Q05397), TNK1 (Q13470)."|figure legend:Suppl. table S3, suppl. fig. S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ySUgohBHmcPaAaD/l21zkQ3+MPI9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:EF441E6B29B3E1C4|rigid:rLhCDLAx9wPuip0MInXtSn5dBug	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46109	uniprotkb:O15033	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	intact:EBI-2831131|uniprotkb:Q7LDY1|uniprotkb:Q8IYY9|uniprotkb:B4E2C7|ensembl:ENSP00000348714|ensembl:ENSP00000505623	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:arel1_human(display_long)|uniprotkb:AREL1(gene name)|psi-mi:AREL1(display_short)|uniprotkb:KIAA0317(gene name synonym)|uniprotkb:Apoptosis-resistant HECT-type E3 ubiquitin transferase 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696375|imex:IM-22632-300	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|entrezgene/locuslink:1399(identity)|refseq:NM_005207.3(identity)	refseq:XP_011535717.1|refseq:NP_001034568.1|ensembl:ENSG00000119682(gene)|ensembl:ENST00000356357(transcript)|ensembl:ENST00000681599(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000569(HECT)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR035983|rcsb pdb:6JX5|rcsb pdb:6LOH|reactome:R-HSA-983168|entrezgene/locuslink:9870(identity)|refseq:NM_001039479.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:zp9Zpv/naHGK4L5oA49hviZs72Y9606	intact-crc:E782A4C435AE53E2|rigid:wigG9ea28WHrU6ExytbqEhqTSNE	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:O14569	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-717654|uniprotkb:A8K552|ensembl:ENSP00000232508|ensembl:ENSP00000391209|ensembl:ENSP00000400454|ensembl:ENSP00000410663	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:c56d2_human(display_long)|uniprotkb:Putative tumor suppressor protein 101F6(gene name synonym)|uniprotkb:CYB561D2(gene name)|psi-mi:CYB561D2(display_short)|uniprotkb:101F6(gene name synonym)|uniprotkb:LUCA12.2(orf name)|uniprotkb:Cytochrome b561 domain-containing protein 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696390|imex:IM-22632-301	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	refseq:NP_001278213.1|refseq:NP_008953.1|ensembl:ENSG00000114395(gene)|ensembl:ENST00000232508(transcript)|ensembl:ENST00000418577(transcript)|ensembl:ENST00000424512(transcript)|ensembl:ENST00000425346(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031982"(vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0140571"(transmembrane ascorbate ferrireductase activity)|go:"GO:0140575"(transmembrane monodehydroascorbate reductase activity)|go:"GO:0140576"(ascorbate homeostasis)|interpro:IPR006593(Cytochrome b561 / ferric reductase transmembrane)|entrezgene/locuslink:11068(identity)|refseq:NM_001291284.1(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:FPgiTQqW5MUC5+i2RxE1jq6lkSs9606	intact-crc:BC4B3EB8761DBDE2|rigid:tDt12o+Dmi8zMIFSg4rfmcnJhCY	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14544	uniprotkb:P46108-2	intact:EBI-3929549|uniprotkb:Q8WUM3|ensembl:ENSP00000381034|ensembl:ENSP00000463395	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:socs6_human(display_long)|uniprotkb:SOCS6(gene name)|psi-mi:SOCS6(display_short)|uniprotkb:CIS4(gene name synonym)|uniprotkb:SOCS4(gene name synonym)|uniprotkb:Cytokine-inducible SH2 protein 4(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 4(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696420|imex:IM-22632-303	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR037345|mint:O14544|rcsb pdb:2VIF|reactome:R-HSA-1433559|reactome:R-HSA-8951664|reactome:R-HSA-9706369|interpro:IPR036860|ensembl:ENSG00000170677(gene)|ensembl:ENST00000397942(transcript)|ensembl:ENST00000582322(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028421|interpro:IPR035865|interpro:IPR036036|refseq:NP_004223.2|refseq:XP_005266840.1|refseq:XP_016881575.1|refseq:XP_016881576.1|refseq:NM_004232.3(identity)|entrezgene/locuslink:9306(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:O++hp+HHhT2m2QNupHdNfK5DBqQ9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:FCF9929021D508C9|rigid:mnfXsSJa6Uh2DAJC2qDtdM6VOFE	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:O14544	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-3929549|uniprotkb:Q8WUM3|ensembl:ENSP00000381034|ensembl:ENSP00000463395	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:socs6_human(display_long)|uniprotkb:SOCS6(gene name)|psi-mi:SOCS6(display_short)|uniprotkb:CIS4(gene name synonym)|uniprotkb:SOCS4(gene name synonym)|uniprotkb:Cytokine-inducible SH2 protein 4(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696405|imex:IM-22632-302	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	interpro:IPR037345|mint:O14544|rcsb pdb:2VIF|reactome:R-HSA-1433559|reactome:R-HSA-8951664|reactome:R-HSA-9706369|interpro:IPR036860|ensembl:ENSG00000170677(gene)|ensembl:ENST00000397942(transcript)|ensembl:ENST00000582322(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028421|interpro:IPR035865|interpro:IPR036036|refseq:NP_004223.2|refseq:XP_005266840.1|refseq:XP_016881575.1|refseq:XP_016881576.1|refseq:NM_004232.3(identity)|entrezgene/locuslink:9306(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:O++hp+HHhT2m2QNupHdNfK5DBqQ9606	intact-crc:2BA8FB8ACCA3DB3A|rigid:zPsHf9WDLt3pTBrqummdh6Z3LlA	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:O14544	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-3929549|uniprotkb:Q8WUM3|ensembl:ENSP00000381034|ensembl:ENSP00000463395	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:socs6_human(display_long)|uniprotkb:SOCS6(gene name)|psi-mi:SOCS6(display_short)|uniprotkb:CIS4(gene name synonym)|uniprotkb:SOCS4(gene name synonym)|uniprotkb:Cytokine-inducible SH2 protein 4(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696435|imex:IM-22632-304	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	interpro:IPR037345|mint:O14544|rcsb pdb:2VIF|reactome:R-HSA-1433559|reactome:R-HSA-8951664|reactome:R-HSA-9706369|interpro:IPR036860|ensembl:ENSG00000170677(gene)|ensembl:ENST00000397942(transcript)|ensembl:ENST00000582322(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028421|interpro:IPR035865|interpro:IPR036036|refseq:NP_004223.2|refseq:XP_005266840.1|refseq:XP_016881575.1|refseq:XP_016881576.1|refseq:NM_004232.3(identity)|entrezgene/locuslink:9306(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:O++hp+HHhT2m2QNupHdNfK5DBqQ9606	intact-crc:02DDADD0F295FFC0|rigid:ORjmfoXBctm9R/40GtD+maSgH0E	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96IW2	uniprotkb:A0A024R0L9	intact:EBI-4402781|uniprotkb:Q96NC2|ensembl:ENSP00000446058	intact:EBI-10696468	psi-mi:shd_human(display_long)|uniprotkb:SHD(gene name)|psi-mi:SHD(display_short)	psi-mi:a0a024r0l9_human(display_long)|uniprotkb:PSG11(gene name)|psi-mi:PSG11(display_short)|uniprotkb:hCG_1995685(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696465|imex:IM-22632-306	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064594.3|ensembl:ENSG00000105251(gene)|go:"GO:0001784"(phosphotyrosine residue binding)|interpro:IPR000980(SH2 motif)|interpro:IPR035039|interpro:IPR035046|interpro:IPR036860|ensembl:ENST00000543264(transcript)|entrezgene/locuslink:56961(identity)|refseq:NM_020209.3(identity)	interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|refseq:NM_001113410.1(identity)|entrezgene/locuslink:5680(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:c2PsXxVdBB1dLj+Lu40XdgOb2yY9606	rogid:+Zxvf2yKA3sKqk9Qc1bnHjpiGdE9606	intact-crc:B0CF06F405CD6171|rigid:PslGsUwyIOpsMH0bLVHJcyT85DM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:O00746	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-744871|uniprotkb:Q5U0M9|ensembl:ENSP00000219479|uniprotkb:A2IDD0	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:ndkm_human(display_long)|uniprotkb:nm23-H4(gene name synonym)|uniprotkb:Nucleoside diphosphate kinase D(gene name synonym)|uniprotkb:NME4(gene name)|psi-mi:NME4(display_short)|uniprotkb:NM23D(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696450|imex:IM-22632-305	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	refseq:NP_001273362.1|refseq:NP_001273364.1|refseq:NP_001273365.1|refseq:NP_001273367.1|refseq:NP_001273368.1|refseq:NP_001273369.1|refseq:NP_005000.1|ensembl:ENSG00000103202(gene)|ensembl:ENST00000219479(transcript)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006869"(lipid transport)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:O00746|rcsb pdb:1EHW|reactome:R-HSA-499943|refseq:NM_005009.2(identity)|entrezgene/locuslink:4833(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:ybA9I8oT+oz1iuGLHT7WR1SAaKY9606	intact-crc:C215B82BBBBBAF91|rigid:LtYOzRYMEpdH6/hIZ9cYjFWUrMw	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14713	intact:EBI-10696484	intact:EBI-2127319|uniprotkb:O14714|uniprotkb:D6W4Y9|uniprotkb:Q53RS0|ensembl:ENSP00000347504|ensembl:ENSP00000353850	-	psi-mi:itbp1_human(display_long)|uniprotkb:ITGB1BP1(gene name)|psi-mi:ITGB1BP1(display_short)|uniprotkb:ICAP1(gene name synonym)|uniprotkb:Integrin cytoplasmic domain-associated protein 1(gene name synonym)	psi-mi:pgrmc1(display_short)|psi-mi:EBI-10696484(display_long)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696487|imex:IM-22632-307	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011508718.1|refseq:NP_004754.1|refseq:NP_071729.1|refseq:XP_016860758.1|refseq:XP_016860759.1|refseq:XP_016860756.1|refseq:XP_016860757.1|refseq:NP_001305995.1|refseq:NP_001305996.1|refseq:NP_001305997.1|refseq:XP_006711966.1|refseq:XP_005246240.1|refseq:XP_005246241.1|refseq:XP_005246242.1|refseq:XP_005246246.1|ensembl:ENSG00000119185(gene)|ensembl:ENST00000355346(transcript)|ensembl:ENST00000360635(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006933"(negative regulation of cell adhesion involved in substrate-bound cell migration)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033622"(integrin activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035148"(tube formation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051451"(myoblast migration)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090315"(negative regulation of protein targeting to membrane)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR019517|rcsb pdb:1K11|rcsb pdb:4DX8|rcsb pdb:4DX9|rcsb pdb:4JIF|refseq:NM_004763.3(identity)|entrezgene/locuslink:9270(identity)	entrezgene/locuslink:10857(identity)|refseq:NM_006667.4(identity)	-	-	no-uniprot-update:	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FER (P16591), FGR (P09769), FYN (P06241)."|comment:"The interaction failed to show if a kinase-dead version of FYN (P06241) was used."|figure legend:Suppl. table S3, suppl. fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:QxRmizA77Dvcwg8rkqt1bt3sI2U9606	rogid:rMnUy1tXawu+c/+lVvFyzcL9yYc9606	intact-crc:1653220597B15E44|rigid:GHmL0u6RXyBdLJ/aq9OjDSCjOCM	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-10696506	uniprotkb:P40763	-	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:mpzl1(display_short)|psi-mi:EBI-10696506(display_long)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696503|imex:IM-22632-308	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	entrezgene/locuslink:9019(identity)|refseq:NM_003953.5(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	no-uniprot-update:	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:1GWPVDd8qhs7qSMespdwAU9jUxY9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:61729D53E382075F|rigid:p5WPKkhPReBhFU+nR7iqRsFV8+o	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-10696506	uniprotkb:Q18PE1	-	intact:EBI-3046647|ensembl:ENSP00000344432|uniprotkb:E9PB56|uniprotkb:Q8NBC1|uniprotkb:Q86XG5|uniprotkb:Q8N2J3|uniprotkb:A2A499|uniprotkb:Q6P6A6|uniprotkb:A2RRD4	psi-mi:mpzl1(display_short)|psi-mi:EBI-10696506(display_long)	psi-mi:dok7_human(display_long)|uniprotkb:DOK7(gene name)|psi-mi:DOK7(display_short)|uniprotkb:C4orf25(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 7(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696521|imex:IM-22632-309	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	entrezgene/locuslink:9019(identity)|refseq:NM_003953.5(identity)	ensembl:ENSG00000175920(gene)|ensembl:ENST00000340083(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045202"(synapse)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037746|interpro:IPR037747|interpro:IPR037748|refseq:NP_001288000.1|refseq:NP_001158145.1|refseq:NP_775931.3|refseq:NP_001243825.1|refseq:NM_173660.4(identity)|entrezgene/locuslink:285489(identity)	-	no-uniprot-update:	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:1GWPVDd8qhs7qSMespdwAU9jUxY9606	rogid:RNSUGsyQVitqfrm+mTmzf0fZHR49606	intact-crc:3AEBFBF83A3CA653|rigid:iIvEkTklatg0dBTXgfFbByWdLQ8	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WXH5	intact:EBI-10696539	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	-	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:ppapdc2(display_short)|psi-mi:EBI-10696539(display_long)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696536|imex:IM-22632-310	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	refseq:NM_203453.3(identity)|entrezgene/locuslink:403313(identity)	-	-	no-uniprot-update:	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	rogid:+Z2B+dJTsflTkv7ROiuer/ulCws9606	intact-crc:188A4454BE70A4EE|rigid:iKVu5Lf6gFqeKaDHyiePniRxH3g	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	intact:EBI-10696557	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	-	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:arap3(display_short)|psi-mi:EBI-10696557(display_long)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696554|imex:IM-22632-311	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	entrezgene/locuslink:64411(identity)|refseq:XM_005268499.1(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	no-uniprot-update:	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:77y7xZURYh8VActT4V+Oof5AWxY9606	intact-crc:EA3D941433C7C985|rigid:7nplytXoxcbohqlE7aA41HcI6qc	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-10696575	uniprotkb:Q92569	-	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:znf767(display_short)|psi-mi:EBI-10696575(display_long)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696572|imex:IM-22632-312	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	entrezgene/locuslink:79970(identity)|refseq:XM_005249956.1(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	no-uniprot-update:	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:bmyvECfdUfkpegeqBiK1W412c5s9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:D5091953B251AECE|rigid:zBLBhiA3EbMsU1GvRVot+/BSx3o	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96JZ2	intact:EBI-10696539	intact:EBI-3919324|intact:EBI-28973686|ensembl:ENSP00000482604|ensembl:ENSP00000483354|uniprotkb:B5ME72|uniprotkb:Q6ZNG7	-	psi-mi:hsh2d_human(display_long)|uniprotkb:HSH2D(gene name)|psi-mi:HSH2D(display_short)|uniprotkb:ALX(gene name synonym)|uniprotkb:Adaptor in lymphocytes of unknown function X(gene name synonym)	psi-mi:ppapdc2(display_short)|psi-mi:EBI-10696539(display_long)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696590|imex:IM-22632-313	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000483354|ensembl:ENSP00000482604|ensembl:ENSG00000196684(gene)|ensembl:ENST00000613986(transcript)|ensembl:ENST00000616645(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR035047|interpro:IPR036860|rcsb pdb:2CS0|go:"GO:0005737"(cytoplasm)|refseq:NP_116244.1|refseq:NP_001278203.1|refseq:NM_032855.3(identity)|entrezgene/locuslink:84941(identity)	refseq:NM_203453.3(identity)|entrezgene/locuslink:403313(identity)	-	-	no-uniprot-update:	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Y01YjkfU/oOtbz2TdQcnm+lBWhs9606	rogid:+Z2B+dJTsflTkv7ROiuer/ulCws9606	intact-crc:6FE09345555854C6|rigid:RYfrqC2BXA6z3sxW1MRax8ofomY	false	phosphorylated residue:?-?	phosphorylated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	uniprotkb:Q8IZQ1	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696607|imex:IM-22632-314	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N|refseq:NM_014991.4(identity)|entrezgene/locuslink:23001(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606	intact-crc:F576C94F3B835007|rigid:cFTUlIgnw6dukeCXKW0TTx17OmU	false	sufficient binding region:125-1409	sufficient binding region:3246-3526	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z6Z7	uniprotkb:Q63HR2	intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696621|imex:IM-22632-315	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N|refseq:XM_005261972.2(identity)|entrezgene/locuslink:10075(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:5674F5FE35FD0338|rigid:SX9opeTj30Dwm3nAAVitqtdUv5g	false	sufficient binding region:4067-4374	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q3MIX3	uniprotkb:Q63HR2	intact:EBI-3923548|uniprotkb:Q8N5V3|uniprotkb:Q5U4P1|uniprotkb:Q6P2S4|ensembl:ENSP00000310547|ensembl:ENSP00000494807|uniprotkb:B3KS46	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:adck5_human(display_long)|uniprotkb:ADCK5(gene name)|psi-mi:ADCK5(display_short)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696635|imex:IM-22632-316	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173137(gene)|ensembl:ENSG00000285451(gene)|ensembl:ENST00000308860(transcript)|ensembl:ENST00000645968(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004147(ABC-1)|interpro:IPR011009(Protein kinase-like)|refseq:NP_777582.4|entrezgene/locuslink:203054(identity)|refseq:XM_006716527.1(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2018/09/18	rogid:22Qosma4EuX8Nt/e0QQO4zefMTg9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:2812CC4A76A06C10|rigid:YALJuWKHthmRGddCVMnOrNUMIiU	false	sufficient binding region:412-580	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	uniprotkb:Q8TEB1	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	intact:EBI-2213388|uniprotkb:Q5D039|uniprotkb:Q86U00|uniprotkb:Q86U39|uniprotkb:Q8NDN2|uniprotkb:Q9H2J0|uniprotkb:Q9H3A3|uniprotkb:Q9H5C9|uniprotkb:D3DS56|uniprotkb:B3KQ83|ensembl:ENSP00000415556|ensembl:ENSP00000452898|ensembl:ENSP00000494282|ensembl:ENSP00000495416	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:dca11_human(display_long)|uniprotkb:DCAF11(gene name)|psi-mi:DCAF11(display_short)|uniprotkb:GL014(orf name)|uniprotkb:PRO2389(orf name)|uniprotkb:WDR23(gene name synonym)|uniprotkb:WD repeat-containing protein 23(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696663|imex:IM-22632-318	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	refseq:NP_001156956.1|refseq:NP_079506.3|refseq:NP_852002.1|ensembl:ENSG00000100897(gene)|ensembl:ENSG00000284796(gene)|ensembl:ENST00000446197(transcript)|ensembl:ENST00000559115(transcript)|ensembl:ENST00000642239(transcript)|ensembl:ENST00000646568(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017399(WD repeat protein 23)|interpro:IPR020472|interpro:IPR036322|mint:Q8TEB1|reactome:R-HSA-8951664|entrezgene/locuslink:80344(identity)|refseq:NM_181357.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:iQQ4lP7NSE1MIcskh1XBjj9CC0s9606	intact-crc:73421174EEDF5A06|rigid:SLycVzCM/0euCXSKVmBhlU9DuZk	false	sufficient binding region:125-1409	sufficient binding region:340-545	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A7E2Y1	uniprotkb:Q63HR2	intact:EBI-2880253|ensembl:ENSP00000483640|uniprotkb:Q5JVW7|uniprotkb:Q6WG75|uniprotkb:Q6NT44|uniprotkb:Q9NWE2|uniprotkb:Q9P216|uniprotkb:Q6NT57|uniprotkb:Q96I57	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:myh7b_human(display_long)|uniprotkb:MYH7B(gene name)|psi-mi:MYH7B(display_short)|uniprotkb:KIAA1512(gene name synonym)|uniprotkb:Antigen MLAA-21(gene name synonym)|uniprotkb:Myosin cardiac muscle beta chain(gene name synonym)|uniprotkb:Myosin heavy chain 7B, cardiac muscle beta isoform(gene name synonym)|uniprotkb:Slow A MYH14(gene name synonym)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696649|imex:IM-22632-317	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016020"(membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0032982"(myosin filament)|go:"GO:0051015"(actin filament binding)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR027417|interpro:IPR036961|mint:A7E2Y1|go:"GO:0005524"(ATP binding)|ensembl:ENSG00000078814(gene)|ensembl:ENST00000618182(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|refseq:NP_065935.3|entrezgene/locuslink:57644(identity)|refseq:NM_020884.4(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2018/04/06	rogid:HCH48jsSn7DEOwokRIJw+VHaKDo9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:D9662A49663ACC95|rigid:yzmIb1sLYzASOEP90As1mIbuKys	false	sufficient binding region:44-218	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TCD5	uniprotkb:Q63HR2	intact:EBI-6137412|uniprotkb:Q96HS6|uniprotkb:Q9NP82|ensembl:ENSP00000245552	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:nt5c_human(display_long)|uniprotkb:NT5C(gene name)|psi-mi:NT5C(display_short)|uniprotkb:DNT1(gene name synonym)|uniprotkb:UMPH2(gene name synonym)|uniprotkb:Cytosolic 5',3'-pyrimidine nucleotidase(gene name synonym)|uniprotkb:Deoxy-5'-nucleotidase 1(gene name synonym)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696677|imex:IM-22632-319	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001239306.1|refseq:NP_055410.1|ensembl:ENSG00000125458(gene)|ensembl:ENST00000245552(transcript)|go:"GO:0000255"(allantoin metabolic process)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006204"(IMP catabolic process)|go:"GO:0006249"(dCMP catabolic process)|go:"GO:0008252"(nucleotidase activity)|go:"GO:0008253"(5'-nucleotidase activity)|go:"GO:0009223"(pyrimidine deoxyribonucleotide catabolic process)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019103"(pyrimidine nucleotide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046055"(dGMP catabolic process)|go:"GO:0046074"(dTMP catabolic process)|go:"GO:0046079"(dUMP catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050483"(IMP 5'-nucleotidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR010708(5 nucleotidase, deoxy, cytosolic type C)|interpro:IPR023214|interpro:IPR036412|rcsb pdb:2I7D|rcsb pdb:4L57|rcsb pdb:4YIH|rcsb pdb:6G2N|reactome:R-HSA-73621|reactome:R-HSA-74259|refseq:XM_006721851.1(identity)|entrezgene/locuslink:30833(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:G9RC/RN5jJ1r66Ky7yWppUP6N6E9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:29E0E7FC0A4CBB15|rigid:VXn/df1WNLBdKswX4gCIyllb05c	false	sufficient binding region:1-109	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y575	uniprotkb:Q63HR2	intact:EBI-2875625|ensembl:ENSP00000263634|ensembl:ENSP00000385085|uniprotkb:Q53TN8|uniprotkb:Q53TN0|uniprotkb:B3KPA3|uniprotkb:Q9NVZ2|uniprotkb:D6W5B4|uniprotkb:D6W5B5|uniprotkb:G8JLA9|uniprotkb:Q2TAI4	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:asb3_human(display_long)|uniprotkb:ASB3(gene name)|psi-mi:ASB3(display_short)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696691|imex:IM-22632-320	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030315"(T-tubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0055117"(regulation of cardiac muscle contraction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036036|interpro:IPR036770|interpro:IPR037329|mint:Q9Y575|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000115239(gene)|ensembl:ENST00000263634(transcript)|ensembl:ENST00000406625(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|refseq:NP_001188894.1|refseq:NP_057199.1|refseq:NP_665862.1|refseq:NP_001157637.1|refseq:NM_016115.4(identity)|entrezgene/locuslink:51130(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:gIMKRtUzf90UdaMhaSwEmesN+KE9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:8AA2C92F84DE55AF|rigid:ukQWCr/hYOfCklYmn3xzqNfMQig	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P1U0	uniprotkb:Q63HR2	intact:EBI-355434|ensembl:ENSP00000407364|ensembl:ENSP00000407715|ensembl:ENSP00000410127|ensembl:ENSP00000410530|ensembl:ENSP00000410954|ensembl:ENSP00000412369|ensembl:ENSP00000413265|ensembl:ENSP00000414110|ensembl:ENSP00000414720|ensembl:ENSP00000416599|ensembl:ENSP00000405636|ensembl:ENSP00000331111|ensembl:ENSP00000352333|ensembl:ENSP00000365978|ensembl:ENSP00000365981|ensembl:ENSP00000373108|ensembl:ENSP00000383500|ensembl:ENSP00000383501|ensembl:ENSP00000383503|ensembl:ENSP00000387914|ensembl:ENSP00000391809|ensembl:ENSP00000393236|ensembl:ENSP00000394779|ensembl:ENSP00000395065|ensembl:ENSP00000395397|ensembl:ENSP00000396661|ensembl:ENSP00000396922|ensembl:ENSP00000397636|ensembl:ENSP00000399302|ensembl:ENSP00000399966|ensembl:ENSP00000402198|ensembl:ENSP00000405264	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:rpa12_human(display_long)|uniprotkb:POLR1H(gene name)|psi-mi:POLR1H(display_short)|uniprotkb:DNA-directed RNA polymerase I subunit H(gene name synonym)|uniprotkb:RPA12(gene name synonym)|uniprotkb:ZNRD1(gene name synonym)|uniprotkb:Zinc ribbon domain-containing protein 1(gene name synonym)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696703|imex:IM-22632-321	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055411.1|refseq:NP_740753.1|refseq:NP_001265714.1|refseq:NP_001265715.1|ensembl:ENST00000332435(transcript)|ensembl:ENST00000359374(transcript)|ensembl:ENST00000376782(transcript)|ensembl:ENST00000376785(transcript)|ensembl:ENST00000383613(transcript)|ensembl:ENST00000400659(transcript)|ensembl:ENST00000400660(transcript)|ensembl:ENST00000400662(transcript)|ensembl:ENST00000412396(transcript)|ensembl:ENST00000417275(transcript)|ensembl:ENST00000417738(transcript)|ensembl:ENST00000420100(transcript)|ensembl:ENST00000428913(transcript)|ensembl:ENST00000429558(transcript)|ensembl:ENST00000431032(transcript)|ensembl:ENST00000431416(transcript)|ensembl:ENST00000432227(transcript)|ensembl:ENST00000432545(transcript)|ensembl:ENST00000432904(transcript)|ensembl:ENST00000433264(transcript)|ensembl:ENST00000437373(transcript)|ensembl:ENST00000437507(transcript)|ensembl:ENST00000441251(transcript)|ensembl:ENST00000442585(transcript)|ensembl:ENST00000443142(transcript)|ensembl:ENST00000443494(transcript)|ensembl:ENST00000444027(transcript)|ensembl:ENST00000444794(transcript)|ensembl:ENST00000446493(transcript)|ensembl:ENST00000451875(transcript)|ensembl:ENST00000455948(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006363"(termination of RNA polymerase I transcription)|go:"GO:0006379"(mRNA cleavage)|go:"GO:0008270"(zinc ion binding)|interpro:IPR001222(Zinc finger, TFIIS-type)|interpro:IPR012164(DNA-directed RNA polymerase, subunit C11/M/9)|interpro:IPR019761|interpro:IPR034004|mint:Q9P1U0|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863|ensembl:ENST00000453694(transcript)|ensembl:ENSG00000066379(gene)|ensembl:ENSG00000206502(gene)|ensembl:ENSG00000224859(gene)|ensembl:ENSG00000233795(gene)|ensembl:ENSG00000235176(gene)|ensembl:ENSG00000235443(gene)|ensembl:ENSG00000236808(gene)|ensembl:ENSG00000236949(gene)|entrezgene/locuslink:30834(identity)|refseq:NM_001278785.1(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:zWLcgopYhtpCPeyhS887IK1ZhNw9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:750502ED00B0A88B|rigid:WSVvGxewBxkKSczRzGI1z2CWpDw	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	intact:EBI-746937	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	-	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:cu077_human(display_short)|psi-mi:EBI-746937(display_long)|uniprotkb:LINC00846(gene name)|psi-mi:LINC00846(display_short)|uniprotkb:C21orf77(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696715|imex:IM-22632-322	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	uniprotkb:Q9NV44(uniprot-removed-ac)|refseq:NM_144659.5(identity)|entrezgene/locuslink:140290(identity)	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:LHX0Q/LJW9e6XJ0d2dMo6ATyQ1I9606	intact-crc:B9372A7687A02F2A|rigid:mgwKZ7aatvE78Eqdjw19F/0lOCM	false	sufficient binding region:125-1409	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	uniprotkb:Q9NUL5	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	intact:EBI-10313866|uniprotkb:Q4G188|uniprotkb:Q8N8V1|uniprotkb:A8MQT9|uniprotkb:Q8IYH6|ensembl:ENSP00000253110	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:shfl_human(display_long)|uniprotkb:SHFL(gene name)|psi-mi:SHFL(display_short)|uniprotkb:C19orf66(gene name synonym)|uniprotkb:FLJ11286(gene name synonym)|uniprotkb:IRAV(gene name synonym)|uniprotkb:Interferon-regulated antiviral protein(gene name synonym)|uniprotkb:RYDEN(gene name synonym)|uniprotkb:Repressor of yield of DENV protein(gene name synonym)|uniprotkb:SFL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696727|imex:IM-22632-323	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	refseq:NP_060851.2|refseq:NP_001295206.1|ensembl:ENSG00000130813(gene)|ensembl:ENST00000253110(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0034340"(response to type I interferon)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034342"(response to type III interferon)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0075523"(viral translational frameshifting)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:2001125"(negative regulation of translational frameshifting)|interpro:IPR026795|refseq:XP_016882423.1|entrezgene/locuslink:55337(identity)|refseq:NM_018381.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:YF1pj1HG6g0dbFln7wTqMGaQpbI9606	intact-crc:3B49077447F8546A|rigid:DlNMq63qIc83MuJxZ3crxNy7QEE	false	sufficient binding region:125-1409	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NSA1	uniprotkb:Q63HR2	intact:EBI-3909329|uniprotkb:Q8N683|ensembl:ENSP00000222157|ensembl:ENSP00000471477	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:fgf21_human(display_long)|uniprotkb:FGF21(gene name)|psi-mi:FGF21(display_short)|uniprotkb:UNQ3115/PRO10196(orf name)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696739|imex:IM-22632-324	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061986.1|ensembl:ENSG00000105550(gene)|ensembl:ENST00000222157(transcript)|ensembl:ENST00000593756(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0014823"(response to activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0035690"|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071377"(cellular response to glucagon stimulus)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904640"(response to methionine)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028292|interpro:IPR035444|mint:Q9NSA1|rcsb pdb:5VAQ|rcsb pdb:6M6E|rcsb pdb:6M6F|reactome:R-HSA-189200|reactome:R-HSA-8963889|go:"GO:0072577"(endothelial cell apoptotic process)|entrezgene/locuslink:26291(identity)|refseq:NM_019113.2(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ZE2K8sYL11qZN3Me0FTU77K/GC09606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:A546460929BB484D|rigid:Xo603/zAG5cpq5r+DQwExne+j3s	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	uniprotkb:Q9HCS5	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	intact:EBI-6658938|ensembl:ENSP00000261486|uniprotkb:A4FUI6	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:e41la_human(display_long)|uniprotkb:EPB41L4A(gene name)|psi-mi:EPB41L4A(display_short)|uniprotkb:EPB41L4(gene name synonym)|uniprotkb:Protein NBL4(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.1-like 4A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696751|imex:IM-22632-325	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	refseq:NP_001334816.1|refseq:NP_071423.4|ensembl:ENSG00000129595(gene)|ensembl:ENST00000261486(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031032"(actomyosin structure organization)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR030696|interpro:IPR035963|entrezgene/locuslink:64097(identity)|refseq:XM_005272043.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:iCdZzwSIn4ZxlND25SHcIxag2Zk9606	intact-crc:09A830DA643C32BF|rigid:iGrOMVmDDPD42/2ry5m1nWtltOs	false	sufficient binding region:125-1409	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H227-2	uniprotkb:Q63HR2	intact:EBI-10696777	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:q9h227-2(display_long)|uniprotkb:Cytosolic glycosylceramidase(gene name synonym)|uniprotkb:Glucosidase beta acid 3(gene name synonym)|uniprotkb:Glucosylceramidase beta 3(gene name synonym)|uniprotkb:Klotho-related protein(gene name synonym)|uniprotkb:GBA3(gene name)|psi-mi:GBA3(display_short)|uniprotkb:CBG(gene name synonym)|uniprotkb:CBGL1(gene name synonym)|uniprotkb:Cytosolic beta-glucosidase-like protein 1(gene name synonym)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696775|imex:IM-22632-327	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-3920615(isoform-parent)|entrezgene/locuslink:57733(identity)|refseq:NM_001128432.2(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:A67FAZuBkAKpokDR1hjJoJWqZXc9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:F32438267F1E3ED1|rigid:PTjMee9Q84eKF/+kKXJfawn7tfE	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H6S3	uniprotkb:Q63HR2	intact:EBI-3940939|uniprotkb:Q53GM8|uniprotkb:Q9H6K9|uniprotkb:B3KSX1|uniprotkb:Q96K06|uniprotkb:Q8WYW7|ensembl:ENSP00000320828|ensembl:ENSP00000435585|ensembl:ENSP00000436035|uniprotkb:B7ZKL3	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:es8l2_human(display_long)|uniprotkb:EPS8L2(gene name)|psi-mi:EPS8L2(display_short)|uniprotkb:EPS8R2(gene name synonym)|uniprotkb:Epidermal growth factor receptor pathway substrate 8-related protein 2(gene name synonym)|uniprotkb:PP13181(orf name)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696763|imex:IM-22632-326	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177106(gene)|ensembl:ENST00000318562(transcript)|ensembl:ENST00000530636(transcript)|ensembl:ENST00000533256(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0031982"(vesicle)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0045296"(cadherin binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q9H6S3|rcsb pdb:1WWU|rcsb pdb:1WXB|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_073609.2|refseq:XP_016873619.1|refseq:XP_016873620.1|refseq:XP_016873621.1|refseq:NM_022772.3(identity)|entrezgene/locuslink:64787(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:fm46f0tF2y2QGPLD7dk77JUHMXA9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:EBBD83E7FD7E36C5|rigid:49VL99++S01/mmM4DciRi2QfqKo	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	uniprotkb:Q9GZX9	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	intact:EBI-10304067|uniprotkb:B2RE08|uniprotkb:Q8NBI7|uniprotkb:D3DUH9|uniprotkb:Q96K46|ensembl:ENSP00000262120	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:twsg1_human(display_long)|uniprotkb:TWSG1(gene name)|psi-mi:TWSG1(display_short)|uniprotkb:TSG(gene name synonym)|uniprotkb:PSEC0250(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696803|imex:IM-22632-329	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	refseq:NP_065699.1|ensembl:ENSG00000128791(gene)|ensembl:ENST00000262120(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005615"(extracellular space)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:2000515"(negative regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR006761("Twisted gastrulation (Tsg) protein")|entrezgene/locuslink:57045(identity)|refseq:NM_020648.5(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:kGlSdtBZVEMZZ8GdRKgGnGUdFYc9606	intact-crc:E4C453710CF96AA5|rigid:9OamrzaJQri2vxhhgop0akYtoZs	false	sufficient binding region:125-1409	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H1D9	uniprotkb:Q63HR2	intact:EBI-710067|uniprotkb:O15319|uniprotkb:A8K4C7|ensembl:ENSP00000366828	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:rpc6_human(display_long)|uniprotkb:DNA-directed RNA polymerase III subunit F(gene name synonym)|uniprotkb:RNA polymerase III 39 kDa subunit(gene name synonym)|uniprotkb:POLR3F(gene name)|psi-mi:POLR3F(display_short)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696791|imex:IM-22632-328	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269455.1|refseq:NP_006457.2|dip:DIP-34646N|ensembl:ENSG00000132664(gene)|ensembl:ENST00000377603(transcript)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|interpro:IPR007832(RNA polymerase Rpc34)|interpro:IPR016049(RNA polymerase Rpc34-like)|interpro:IPR036388|interpro:IPR036390|mint:Q9H1D9|rcsb pdb:2DK5|rcsb pdb:2YU3|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|entrezgene/locuslink:10621(identity)|refseq:NM_006466.3(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uqwUHkGa31Zl21767NrQK6nKbF09606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:3648ACC3FEA811CD|rigid:zzzBumYqlGed7YTMzDm/wXwk5lA	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9C004	uniprotkb:Q63HR2	intact:EBI-354861|uniprotkb:Q6QIX2|uniprotkb:A4FVB3|uniprotkb:Q9C003|uniprotkb:A4FVB2|ensembl:ENSP00000399468	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:spy4_human(display_long)|uniprotkb:SPRY4(gene name)|psi-mi:SPRY4(display_short)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696815|imex:IM-22632-330	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001120968.1|refseq:NP_112226.2|refseq:NP_001280218.1|refseq:NP_001280219.1|refseq:XP_011535987.1|refseq:XP_016865399.1|ensembl:ENSG00000187678(gene)|ensembl:ENST00000434127(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048513"(animal organ development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007875(Sprouty)|interpro:IPR030790|mint:Q9C004|rcsb pdb:3BUN|entrezgene/locuslink:81848(identity)|refseq:NM_001127496.1(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:NjkIqofg1Fl1PXj8FXVFz10JOUg9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:B67B19FF9DC84FDC|rigid:OsWubOs+Ikv1tihp+E0o0wUZaBg	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BYR8	uniprotkb:Q63HR2	intact:EBI-9996449|uniprotkb:Q14DM4|ensembl:ENSP00000375430|ensembl:ENSP00000459883	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:kra31_human(display_long)|uniprotkb:KRTAP3-1(gene name)|psi-mi:KRTAP3-1(display_short)|uniprotkb:KAP3.1(gene name synonym)|uniprotkb:KRTAP3.1(gene name synonym)|uniprotkb:High sulfur keratin-associated protein 3.1(gene name synonym)|uniprotkb:Keratin-associated protein 3.1(gene name synonym)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696827|imex:IM-22632-331	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114164.1|ensembl:ENSG00000212901(gene)|ensembl:ENSG00000262068(gene)|ensembl:ENST00000391588(transcript)|ensembl:ENST00000571440(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0045095"(keratin filament)|interpro:IPR007659(Keratin, high-sulphur matrix protein)|reactome:R-HSA-6805567|entrezgene/locuslink:83896(identity)|refseq:NM_031958.1(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:KZdjlufkxmvI0a7OQ/s8BbBVWZo9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:9A7AB1E1499E753F|rigid:yGnz0DNLD6HikMCV66+yCjVqZaY	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96IP4	uniprotkb:Q63HR2	intact:EBI-954084|uniprotkb:Q5TF86|uniprotkb:Q8NFZ9|uniprotkb:Q9BW32|uniprotkb:Q9NXV5|uniprotkb:A8K7U4|ensembl:ENSP00000318298	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:tet5a_human(display_long)|uniprotkb:TENT5A(gene name)|psi-mi:TENT5A(display_short)|uniprotkb:C6orf37(gene name synonym)|uniprotkb:FAM46A(gene name synonym)|uniprotkb:HBV X-transactivated gene 11 protein(gene name synonym)|uniprotkb:HBV XAg-transactivated protein 11(gene name synonym)|uniprotkb:XTP11(gene name synonym)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696839|imex:IM-22632-332	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060103.2|ensembl:ENSG00000112773(gene)|ensembl:ENST00000320172(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0048255"(mRNA stabilization)|go:"GO:1990817"(RNA adenylyltransferase activity)|interpro:IPR012937(Protein of unknown function DUF1693)|entrezgene/locuslink:55603(identity)|refseq:NM_017633.2(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:RoYW7NusMegWdnScxOvz6GI6Kjo9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:7355F49BAB771FB4|rigid:I42omuTselfSLX65jP6Bpumzsvk	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96DZ7	uniprotkb:Q63HR2	intact:EBI-6448756|ensembl:ENSP00000273695|uniprotkb:E9PH22|uniprotkb:B2RV20|uniprotkb:Q336K7	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:t4s19_human(display_long)|uniprotkb:Osteoclast maturation-associated gene 4 protein(gene name synonym)|uniprotkb:Tetraspan membrane protein OCTM4(gene name synonym)|uniprotkb:TM4SF19(gene name)|psi-mi:TM4SF19(display_short)|uniprotkb:OCTM4(gene name synonym)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696851|imex:IM-22632-333	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145107(gene)|ensembl:ENST00000273695(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008661(L6 membrane)|refseq:NP_001191827.1|refseq:NP_612470.2|refseq:NM_138461.3(identity)|entrezgene/locuslink:116211(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:0pi3aVpxzi5UX4o8+w7qSluVefU9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:75C7659FC6C8389E|rigid:F7eS63rcD1Qzt0RSRtZRrlIVYqA	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96BA5	uniprotkb:Q63HR2	intact:EBI-10696875|intact:EBI-12198381|intact:EBI-12836366	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:q96ba5_human(display_long)|uniprotkb:SH2B3(gene name)|psi-mi:SH2B3(display_short)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696879|imex:IM-22632-335	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278353.1|entrezgene/locuslink:10019(identity)|refseq:NM_001291424.1(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:YWb/nPE4GS2QdS1lrC7lWLgq9lc9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:3C0C85C20F8EF576|rigid:hYno+heCNk66meszx7rITWstDV4	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	uniprotkb:Q96D03	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	intact:EBI-742054|uniprotkb:B2R7C3|ensembl:ENSP00000354830	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:ddt4l_human(display_long)|uniprotkb:Protein regulated in development and DNA damage response 2(gene name synonym)|uniprotkb:HIF-1 responsive protein RTP801-like(gene name synonym)|uniprotkb:DDIT4L(gene name)|psi-mi:DDIT4L(display_short)|uniprotkb:REDD2(gene name synonym)|uniprotkb:RTP801L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696863|imex:IM-22632-334	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	refseq:NP_660287.1|ensembl:ENSG00000145358(gene)|ensembl:ENST00000273990(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0009968"(negative regulation of signal transduction)|interpro:IPR012918(RTP801, C-terminal)|interpro:IPR038281|refseq:NM_145244.3(identity)|entrezgene/locuslink:115265(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:DHXiWraTchl3LZgh/lXlUr3LKwE9606	intact-crc:CD735F16ADBBEBA0|rigid:e0zA1L6uXSTXWOqHrAHRMQ9TLgk	false	sufficient binding region:125-1409	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92574	uniprotkb:Q63HR2	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696891|imex:IM-22632-336	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1|entrezgene/locuslink:7248(identity)|refseq:XM_006717272.1(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:7038769D0E15BA28|rigid:8wjzmIpmGsIpKKgVfvAGWTQnalI	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	uniprotkb:Q8N720	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	intact:EBI-625509|ensembl:ENSP00000252713|ensembl:ENSP00000377718|uniprotkb:Q8IV00|uniprotkb:Q8TA89|uniprotkb:Q96EZ3|uniprotkb:A4D291|uniprotkb:B4E3M4|uniprotkb:B7Z9Q9|intact:EBI-741438|uniprotkb:Q9BQ85|uniprotkb:D6W5T4|uniprotkb:A6NGD3	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:zn655_human(display_long)|uniprotkb:Vav-interacting Krueppel-like protein(gene name synonym)|uniprotkb:ZNF655(gene name)|psi-mi:ZNF655(display_short)|uniprotkb:VIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696915|imex:IM-22632-338	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	ensembl:ENSG00000197343(gene)|ensembl:ENST00000252713(transcript)|ensembl:ENST00000394163(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-HSA-212436|refseq:NP_001009960.1|refseq:NP_001077425.1|refseq:NP_001078835.1|refseq:NP_001078836.1|refseq:NP_001078837.1|refseq:NP_076966.1|refseq:NP_612503.1|refseq:NP_001009958.1|refseq:XP_016868092.1|refseq:XP_016868093.1|refseq:XP_016868095.1|refseq:XP_016868096.1|dip:DIP-34108N|entrezgene/locuslink:79027(identity)|refseq:NM_001009960.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:kz0A7h281PEWFM7dsPGoPyTAMgs9606	intact-crc:81CE521C73C1032E|rigid:ZZqmToMhr7fSy+o9Ea9dFzkyBfY	false	sufficient binding region:125-1409	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N779	uniprotkb:Q63HR2	intact:EBI-10267476	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:q8n779_human(display_long)|uniprotkb:hCG_1998195(orf name)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696903|imex:IM-22632-337	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	entrezgene/locuslink:91869(identity)|refseq:NM_052859.3(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:KRdDjoDUS6Lxo6Z5ax0wx7otmrA9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:336604F62E7FAAF3|rigid:PXNOaC2AAebWWFPfs/e7COjbi6Q	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	uniprotkb:Q8N6X9	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	intact:EBI-10696927	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:q8n6x9_human(display_long)|uniprotkb:ZNF586(gene name)|psi-mi:ZNF586(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696931|imex:IM-22632-339	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	interpro:IPR001909(Krueppel-associated  box)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR036051|refseq:NM_017652.3(identity)|entrezgene/locuslink:54807(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:eOuwARR7DFlqTRBp+qvMmNKd1UA9606	intact-crc:BE46A30F86E94478|rigid:Yiu1dd2B88jCiqUnLvV5CoHiDKA	false	sufficient binding region:125-1409	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IWE2	uniprotkb:Q63HR2	intact:EBI-2686288|uniprotkb:Q6MZV4|uniprotkb:A8K9W6|uniprotkb:Q9BVL6|ensembl:ENSP00000351740	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:nxp20_human(display_long)|uniprotkb:NOXP20(gene name synonym)|uniprotkb:Protein FAM114A1(gene name synonym)|uniprotkb:FAM114A1(gene name)|psi-mi:FAM114A1(display_short)|uniprotkb:Nervous system overexpressed protein 20(gene name synonym)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696943|imex:IM-22632-340	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612398.2|refseq:XP_005262729.1|ensembl:ENSG00000197712(gene)|ensembl:ENST00000358869(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|interpro:IPR007998(Protein of unknown function DUF719)|refseq:NP_001317693.1|entrezgene/locuslink:92689(identity)|refseq:NM_138389.2(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:LjjPhFyL25/vnOtP5bzZBjKIRxs9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:A5807A12C6C8EF5C|rigid:shWvcVA9ItdU7VZ/Vk1xJ/cHTuo	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	uniprotkb:Q86SQ7-2	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	intact:EBI-10696955	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:q86sq7-2(display_long)|uniprotkb:SDCCAG8(gene name)|psi-mi:SDCCAG8(display_short)|uniprotkb:Antigen NY-CO-8(gene name synonym)|uniprotkb:CCCAP(gene name synonym)|uniprotkb:Centrosomal colon cancer autoantigen protein(gene name synonym)|uniprotkb:NPHP10(gene name synonym)|uniprotkb:HSPC085(orf name)|uniprotkb:e(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696959|imex:IM-22632-341	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	intact:EBI-1047850(isoform-parent)|uniprotkb:Q86SQ7-2(isoform-parent)|refseq:XM_005273023.2(identity)|entrezgene/locuslink:10806(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:ADFI0SPEQfJYjUYcyJKJOPn2DQ49606	intact-crc:507C559588931636|rigid:DXgO17s8ZMVm6cHOjaocXVvS4xE	false	sufficient binding region:125-1409	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	uniprotkb:Q7Z6I5	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	intact:EBI-10696971|uniprotkb:B2RMW1|uniprotkb:A0AVA8|ensembl:ENSP00000335392	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:spt12_human(display_long)|uniprotkb:SPATA12(gene name)|psi-mi:SPATA12(display_short)|uniprotkb:SRG5(gene name synonym)|uniprotkb:Spermatogenesis-related protein 5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696977|imex:IM-22632-342	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	refseq:NP_859078.1|refseq:XP_011531978.1|ensembl:ENSG00000186451(gene)|ensembl:ENST00000334325(transcript)|entrezgene/locuslink:353324(identity)|refseq:NM_181727.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:wclT+6HU+T7AK3KNk+1VbkI+v389606	intact-crc:825ACBA6847AAA78|rigid:kr/WAYrgX+C9m96vaSx1M//FjhM	false	sufficient binding region:125-1409	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7L591-3	uniprotkb:Q63HR2	intact:EBI-10694655|ensembl:ENSP00000325174	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10696989|imex:IM-22632-343	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:D00CDA5D8887D051|rigid:rXKQsCeRphyvEJB66Eg+uHe46JA	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	uniprotkb:Q6YFQ2	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	intact:EBI-10291911|uniprotkb:Q96DL5|uniprotkb:Q7L1R4|ensembl:ENSP00000320672|ensembl:ENSP00000467128|ensembl:ENSP00000467266|ensembl:ENSP00000467959|ensembl:ENSP00000476768	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:cx6b2_human(display_long)|uniprotkb:COX6B2(gene name)|psi-mi:COX6B2(display_short)|uniprotkb:Cancer/testis antigen 59(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIb isoform 2(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIb, testis-specific isoform(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697001|imex:IM-22632-344	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	refseq:NP_653214.2|ensembl:ENSG00000160471(gene)|ensembl:ENST00000326529(transcript)|ensembl:ENST00000588572(transcript)|ensembl:ENST00000589467(transcript)|ensembl:ENST00000590900(transcript)|ensembl:ENST00000593184(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0045277"(respiratory chain complex IV)|interpro:IPR003213(Cytochrome c oxidase, subunit VIb)|interpro:IPR036549|refseq:NM_144613.4(identity)|entrezgene/locuslink:125965(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:ff8fBXAOJzYZSmmR9KI8pU3RzJI9606	intact-crc:A4E5FD48D9AF1AA8|rigid:t5FKknoM9wUghQnXY20IKgECv2c	false	sufficient binding region:125-1409	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6P1J6-2	uniprotkb:Q63HR2	intact:EBI-10694821	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:q6p1j6-2(display_long)|uniprotkb:PLB1(gene name)|psi-mi:PLB1(display_short)|uniprotkb:PLB(gene name synonym)|uniprotkb:Phospholipase B/lipase(gene name synonym)|uniprotkb:Lysophospholipase(gene name synonym)|uniprotkb:Phospholipase A2(gene name synonym)|uniprotkb:Triacylglycerol lipase(gene name synonym)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697013|imex:IM-22632-345	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-10757275(isoform-parent)|uniprotkb:Q6P1J6-2(isoform-parent)|refseq:NM_153021.4(identity)|entrezgene/locuslink:151056(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:WLweRT1dlb70eDlX6qsoWBzXA6c9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:1F5F5F928B672C55|rigid:eMph3dL7nAOigwL062Wr+l+omEg	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	uniprotkb:Q5TAQ9	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	intact:EBI-740686|uniprotkb:Q12839|uniprotkb:Q4QQI6|uniprotkb:Q53F14|uniprotkb:Q66K50|uniprotkb:Q68CS7|uniprotkb:Q96E00|intact:EBI-2559125|uniprotkb:D3DVE6|ensembl:ENSP00000318227|ensembl:ENSP00000357052|ensembl:ENSP00000357053	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:dcaf8_human(display_long)|uniprotkb:DCAF8(gene name)|psi-mi:DCAF8(display_short)|uniprotkb:H326(gene name synonym)|uniprotkb:WDR42A(gene name synonym)|uniprotkb:WD repeat-containing protein 42A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697025|imex:IM-22632-346	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	refseq:NP_056541.2|ensembl:ENSG00000132716(gene)|ensembl:ENST00000326837(transcript)|ensembl:ENST00000368073(transcript)|ensembl:ENST00000368074(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:Q5TAQ9|rcsb pdb:3I8E|reactome:R-HSA-8951664|dip:DIP-48762N|refseq:NM_015726.3(identity)|entrezgene/locuslink:50717(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:6Bbv6KwtHrJ0W4mcIronVPj4bTA9606	intact-crc:7E1DD617BAF6D0BC|rigid:1kFroSgIvjFZnp8F0ExuePYrauQ	false	sufficient binding region:125-1409	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q2M385	uniprotkb:Q63HR2	intact:EBI-2826504|uniprotkb:Q2M1T6|uniprotkb:Q8TEF8|ensembl:ENSP00000354335	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:mpeg1_human(display_long)|uniprotkb:Perforin-2(gene name synonym)|uniprotkb:MPEG1(gene name)|psi-mi:MPEG1(display_short)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697037|imex:IM-22632-347	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034485.1|ensembl:ENSG00000197629(gene)|ensembl:ENST00000361050(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR020864|interpro:IPR039707|rcsb pdb:6U23|rcsb pdb:6U2J|rcsb pdb:6U2K|rcsb pdb:6U2L|rcsb pdb:6U2W|refseq:NM_001039396.1(identity)|entrezgene/locuslink:219972(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:dMq3zTZSMVp5/r562gvoFXWGZMk9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:77D545BA3CD9FA38|rigid:ufB46DNYEtYUN1VoCegrt6VDPn4	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	uniprotkb:Q13610	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	intact:EBI-1050630|uniprotkb:A8K3R6|ensembl:ENSP00000387365|uniprotkb:Q7Z3X9	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:pwp1_human(display_long)|uniprotkb:Keratinocyte protein IEF SSP 9502(gene name synonym)|uniprotkb:PWP1(gene name)|psi-mi:PWP1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697049|imex:IM-22632-348	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	refseq:NP_008993.1|refseq:NP_001304892.1|ensembl:ENSG00000136045(gene)|ensembl:ENST00000412830(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006364"(rRNA processing)|go:"GO:0033140"(negative regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0034773"(histone H4-K20 trimethylation)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990889"(H4K20me3 modified histone binding)|go:"GO:2000738"(positive regulation of stem cell differentiation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR044285|mint:Q13610|refseq:NM_007062.1(identity)|entrezgene/locuslink:2308(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:3LMa4f6IxjpvEoh2Hyu0hHKkY789606	intact-crc:E19C3D3483F7FB97|rigid:40vqV4gFDltMvXq6Dn8PdK7F+Lg	false	sufficient binding region:125-1409	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02363	uniprotkb:Q63HR2	intact:EBI-713450|ensembl:ENSP00000234091|ensembl:ENSP00000379585|ensembl:ENSP00000385465	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:id2_human(display_long)|uniprotkb:Inhibitor of DNA binding 2(gene name synonym)|uniprotkb:ID2(gene name)|psi-mi:ID2(display_short)|uniprotkb:BHLHB26(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 26(gene name synonym)|uniprotkb:Inhibitor of differentiation 2(gene name synonym)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697061|imex:IM-22632-349	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115738(gene)|ensembl:ENST00000234091(transcript)|ensembl:ENST00000331129(transcript)|ensembl:ENST00000396290(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0003166"(bundle of His development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030154"(cell differentiation)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045578"(negative regulation of B cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061031"(endodermal digestive tract morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071931"(positive regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090398"(cellular senescence)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR026052|interpro:IPR036638|mint:Q02363|rcsb pdb:4AYA|reactome:R-HSA-9031628|refseq:NP_002157.2|dip:DIP-46874N|entrezgene/locuslink:3398(identity)|refseq:NM_002166.4(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:zKX4mIq64fyS8DVPGQNeL7+c50w9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:9DCA0725912000E3|rigid:a9PMLlpiXoamT06KY1qGLkjQg7U	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P56377	uniprotkb:Q63HR2	intact:EBI-1054374|uniprotkb:O95326|uniprotkb:Q9H2N6|uniprotkb:B4DSU4|ensembl:ENSP00000328789	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:ap1s2_human(display_long)|uniprotkb:Sigma-adaptin 1B(gene name synonym)|uniprotkb:Sigma1B-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin sigma-1B subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 sigma-1B small chain(gene name synonym)|uniprotkb:Sigma 1B subunit of AP-1 clathrin(gene name synonym)|uniprotkb:AP1S2(gene name)|psi-mi:AP1S2(display_short)|uniprotkb:DC22(orf name)|uniprotkb:Adaptor protein complex AP-1 subunit sigma-1B(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit sigma-1B(gene name synonym)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697073|imex:IM-22632-350	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011543901.1|refseq:NP_003907.3|ensembl:ENSG00000182287(gene)|ensembl:ENST00000329235(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030119"(AP-type membrane coat adaptor complex)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR044733|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|refseq:XP_016885414.1|entrezgene/locuslink:8905(identity)|refseq:NM_003916.4(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Lm3dKqbQS+oUp/MVGC4gHXBBag09606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:E54DC698CDA88C5E|rigid:KTt1Ij7EXwmbMvejHMBBrtj4yeg	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	uniprotkb:P46109	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697097|imex:IM-22632-352	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|entrezgene/locuslink:1399(identity)|refseq:NM_005207.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	intact-crc:43209F3CE49B8D08|rigid:yRA0i4WDgihX9CBQX8mdntbTsmU	false	sufficient binding region:125-1409	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48645	uniprotkb:Q63HR2	intact:EBI-10210351|ensembl:ENSP00000264218	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:nmu_human(display_long)|uniprotkb:NMU(gene name)|psi-mi:NMU(display_short)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697085|imex:IM-22632-351	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278974.1|refseq:NP_001278975.1|refseq:NP_006672.1|ensembl:ENSG00000109255(gene)|ensembl:ENST00000264218(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001696"(gastric acid secretion)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009648"(photoperiodism)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031652"(positive regulation of heat generation)|go:"GO:0031839"(type 1 neuromedin U receptor binding)|go:"GO:0031840"(type 2 neuromedin U receptor binding)|go:"GO:0042755"(eating behavior)|go:"GO:0042922"(neuromedin U receptor binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0060455"(negative regulation of gastric acid secretion)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120061"(negative regulation of gastric emptying)|go:"GO:0120069"(positive regulation of stomach fundus smooth muscle contraction)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903999"(negative regulation of eating behavior)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR008200(Neuromedin U, C-terminal)|interpro:IPR018070|interpro:IPR042384|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0050806"(positive regulation of synaptic transmission)|refseq:NM_006681.3(identity)|entrezgene/locuslink:10874(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:QWmw0RwtTufMQqly4y2gbFlvTaw9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:B1CE470D9DADE9A6|rigid:coT++2LjzrTNeG2mzYw9Q5gHNOU	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	uniprotkb:P15976	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	intact:EBI-3909284|uniprotkb:Q96GB8|ensembl:ENSP00000365858	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:gata1_human(display_long)|uniprotkb:GATA1(gene name)|psi-mi:GATA1(display_short)|uniprotkb:ERYF1(gene name synonym)|uniprotkb:GF1(gene name synonym)|uniprotkb:Eryf1(gene name synonym)|uniprotkb:GATA-binding factor 1(gene name synonym)|uniprotkb:NF-E1 DNA-binding protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697109|imex:IM-22632-353	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	refseq:NP_002040.1|ensembl:ENSG00000102145(gene)|ensembl:ENST00000376670(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030222"(eosinophil differentiation)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035854"(eosinophil fate commitment)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR029524|interpro:IPR039355|mint:P15976|rcsb pdb:6G0Q|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-983231|dip:DIP-41431N|entrezgene/locuslink:2623(identity)|refseq:NM_002049.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:Y/36ySlvsXrGtNSXa4y3Vl7iaJk9606	intact-crc:0F694F78E610E150|rigid:KjnUEpuTPqqQRVcVGafCdmPgNo4	false	sufficient binding region:125-1409	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02795	uniprotkb:Q63HR2	intact:EBI-996616|uniprotkb:Q2HXR9|uniprotkb:Q53XT9|uniprotkb:Q14823|ensembl:ENSP00000245185	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:mt2_human(display_long)|uniprotkb:Metallothionein-II(gene name synonym)|uniprotkb:Metallothionein-2A(gene name synonym)|uniprotkb:MT2A(gene name)|psi-mi:MT2A(display_short)|uniprotkb:CES1(gene name synonym)|uniprotkb:MT2(gene name synonym)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697121|imex:IM-22632-354	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005944.1|ensembl:ENSG00000125148(gene)|ensembl:ENST00000245185(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0036018"(cellular response to erythropoietin)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P02795|rcsb pdb:1MHU|rcsb pdb:2MHU|go:"GO:0006882"(cellular zinc ion homeostasis)|reactome:R-HSA-877300|reactome:R-HSA-5661231|dip:DIP-35232N|refseq:NM_005953.3(identity)|entrezgene/locuslink:4502(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3adUmT5As6Rn1isYoH+jMsFKEgU9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:D1BEE4693EC4CA07|rigid:ByRwpNQ3ZgKMmdxZ/IeFiXCUDLs	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	uniprotkb:O43597	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	intact:EBI-742487|uniprotkb:Q5T6Z7|ensembl:ENSP00000366306|ensembl:ENSP00000366308|uniprotkb:B2R9J9	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:spy2_human(display_long)|uniprotkb:SPRY2(gene name)|psi-mi:SPRY2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697133|imex:IM-22632-355	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	refseq:NP_005833.1|rcsb pdb:5HL0|reactome:R-HSA-1295596|reactome:R-HSA-182971|rcsb pdb:5HKZ|ensembl:ENST00000377102(transcript)|ensembl:ENST00000377104(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000136158(gene)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048513"(animal organ development)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060437"(lung growth)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1902747"(negative regulation of lens fiber cell differentiation)|go:"GO:1990752"(microtubule end)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007875(Sprouty)|interpro:IPR030780|mint:O43597|rcsb pdb:3BUM|rcsb pdb:3OB1|rcsb pdb:5HKY|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001305465.1|refseq:NP_001305466.1|refseq:NP_001305467.1|entrezgene/locuslink:10253(identity)|refseq:NM_005842.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:u1omauzisc6MdZlogMotUmtauSI9606	intact-crc:2BD99F8427B93845|rigid:mrIiN0h953icbqk2XtcWEUVFAUg	false	sufficient binding region:125-1409	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	uniprotkb:O43463	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	intact:EBI-349968|uniprotkb:Q53G60|uniprotkb:Q6FHK6|ensembl:ENSP00000365877|uniprotkb:B2R6E8|uniprotkb:B4DST0	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:suv91_human(display_long)|uniprotkb:SUV39H1(gene name)|psi-mi:SUV39H1(display_short)|uniprotkb:SUV39H(gene name synonym)|uniprotkb:KMT1A(gene name synonym)|uniprotkb:Suppressor of variegation 3-9 homolog 1(gene name synonym)|uniprotkb:Position-effect variegation 3-9 homolog(gene name synonym)|uniprotkb:Histone H3-K9 methyltransferase 1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 1A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697145|imex:IM-22632-356	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	refseq:NP_003164.1|ensembl:ENSG00000101945(gene)|ensembl:ENST00000376687(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0006325"(chromatin organization)|go:"GO:0006364"(rRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0036123"(histone H3-K9 dimethylation)|go:"GO:0036124"(histone H3-K9 trimethylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR000953(Chromo domain)|interpro:IPR001214(SET)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR011381(Histone H3-K9 methyltransferase)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|mint:O43463|rcsb pdb:3MTS|reactome:R-HSA-3214841|reactome:R-HSA-427359|refseq:NP_001269095.1|dip:DIP-32589N|refseq:NM_003173.3(identity)|entrezgene/locuslink:6839(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:dbenLwo5hxhGzFD4sLNOVUveElM9606	intact-crc:9D7B2A1EDBE29ABA|rigid:JWyIe/D78rCmr3g3+lbKOZmyLrM	false	sufficient binding region:125-1409	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15540	uniprotkb:Q63HR2	intact:EBI-10697159|uniprotkb:Q6IAU7|uniprotkb:B2R4L1|uniprotkb:Q9H047|uniprotkb:O14951|ensembl:ENSP00000357429	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:fabp7_human(display_long)|uniprotkb:FABP7(gene name)|psi-mi:FABP7(display_short)|uniprotkb:BLBP(gene name synonym)|uniprotkb:Brain lipid-binding protein(gene name synonym)|uniprotkb:Brain-type fatty acid-binding protein(gene name synonym)|uniprotkb:FABPB(gene name synonym)|uniprotkb:Fatty acid-binding protein 7(gene name synonym)|uniprotkb:MRG(gene name synonym)|uniprotkb:Mammary-derived growth inhibitor related(gene name synonym)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697157|imex:IM-22632-357	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001437.1|ensembl:ENSG00000164434(gene)|ensembl:ENST00000368444(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0050673"(epithelial cell proliferation)|interpro:IPR000463(Cytosolic fatty-acid binding)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|interpro:IPR031259|rcsb pdb:1FDQ|rcsb pdb:1FE3|rcsb pdb:1JJX|rcsb pdb:5URA|rcsb pdb:6L9O|reactome:R-HSA-163560|reactome:R-HSA-9013508|refseq:NP_001305968.1|entrezgene/locuslink:2173(identity)|refseq:NM_001446.3(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:QHHqFaWTq9Hvs98AUiOffBz4N+09606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:D1CD4A0A57D9C37F|rigid:GKfx01Xe7VOwviJqYY+iO0nzb9k	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15534	uniprotkb:Q63HR2	intact:EBI-2557276|uniprotkb:B4DI49|uniprotkb:B2RPA8|uniprotkb:D3DTR3|ensembl:ENSP00000314420	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:per1_human(display_long)|uniprotkb:KIAA0482(gene name synonym)|uniprotkb:PER(gene name synonym)|uniprotkb:RIGUI(gene name synonym)|uniprotkb:Circadian clock protein PERIOD 1(gene name synonym)|uniprotkb:Circadian pacemaker protein Rigui(gene name synonym)|uniprotkb:PER1(gene name)|psi-mi:PER1(display_short)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697177|imex:IM-22632-358	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000179094(gene)|ensembl:ENST00000317276(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051591"(response to cAMP)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:1UL6|reactome:R-HSA-400253|refseq:NP_002607.2|refseq:XP_005256746.1|ensembl:ENSP00000314420|ensembl:ENST00000354903|ensembl:ENSP00000346979|dip:DIP-56603N|refseq:XM_005256690.1(identity)|entrezgene/locuslink:5187(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:pLY3Sbn659CD2bY07SU8ysJxSSg9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:5A1F6664C20AEC5E|rigid:XkC6CQsgb2++ITIcFQwLk9zRYac	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A2RUH7	uniprotkb:Q63HR2	intact:EBI-9088235|uniprotkb:B7ZME5|uniprotkb:Q5T2Z7|ensembl:ENSP00000349678	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	psi-mi:mbphl_human(display_long)|uniprotkb:MYBPHL(gene name)|psi-mi:MYBPHL(display_short)	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697189|imex:IM-22632-359	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001010985.2|refseq:NP_001252542.1|refseq:XP_016856662.1|refseq:XP_016856663.1|refseq:XP_016856664.1|ensembl:ENSG00000221986(gene)|ensembl:ENST00000357155(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0030017"(sarcomere)|go:"GO:0036379"(myofilament)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|refseq:NM_001010985.2(identity)|entrezgene/locuslink:343263(identity)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:p/qILEwJE1MLKT/BPKjI2Q8YUqk9606	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	intact-crc:72A72398E5E91B13|rigid:osMb2lZWsI1xOW61pg4/8CCeIgk	false	-	sufficient binding region:125-1409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	uniprotkb:A1A580	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	intact:EBI-10171734|ensembl:ENSP00000346536	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:kr231_human(display_long)|uniprotkb:KRTAP23-1(gene name)|psi-mi:KRTAP23-1(display_short)|uniprotkb:KAP23.1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697201|imex:IM-22632-360	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	refseq:NP_853655.1|ensembl:ENSG00000186980(gene)|ensembl:ENST00000334160(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|interpro:IPR007951(PMG)|reactome:R-HSA-6805567|refseq:NM_181624.1(identity)|entrezgene/locuslink:337963(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:f4cmeJxOBtVDCUkZueLQEMldjP89606	intact-crc:0561887E61690CF4|rigid:CmOEXXPxWpuhaqtBznsvp7RBcQI	false	sufficient binding region:125-1409	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63HR2	intact:EBI-10697215	intact:EBI-949753|ensembl:ENSP00000319684|uniprotkb:A2VDF2|uniprotkb:A2VDF3|uniprotkb:A2VDI8|uniprotkb:Q2NL80|uniprotkb:Q76MW6|uniprotkb:Q7Z5T9|uniprotkb:Q8NFF9|uniprotkb:Q8NFG0|uniprotkb:Q96P25|uniprotkb:Q9NT29|uniprotkb:Q9UPS7|uniprotkb:A5PKY4	-	psi-mi:tns2_human(display_long)|uniprotkb:TNS2(gene name)|psi-mi:TNS2(display_short)|uniprotkb:C1 domain-containing phosphatase and tensin homolog(gene name synonym)|uniprotkb:KIAA1075(gene name synonym)|uniprotkb:TENC1(gene name synonym)|uniprotkb:Tensin-like C1 domain-containing phosphatase(gene name synonym)	psi-mi:obsl1(display_short)|psi-mi:EBI-10697215(display_long)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697213|imex:IM-22632-361	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000314250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019900"(kinase binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048871"(multicellular organismal homeostasis)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|mint:Q63HR2|rcsb pdb:2DKQ|rcsb pdb:2KNO|rcsb pdb:2L6K|rcsb pdb:2LOZ|rcsb pdb:3HQC|ensembl:ENSG00000111077(gene)|refseq:NP_056134.2|refseq:NP_736610.2|refseq:NP_938072.1|entrezgene/locuslink:23371(identity)|refseq:NM_198316.1(identity)	entrezgene/locuslink:23363(identity)|refseq:NM_001173408.1(identity)	-	-	no-uniprot-update:	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uobqTi6g78V5Iib3uRGGhqjSt7o9606	rogid:fTiVmOYmDnBTcZQsiBN7oei/qX49606	intact-crc:728C3A138EAFC6F7|rigid:wGif33Rp78fPd9uzXWCL87OOUtk	false	sufficient binding region:125-1409	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H788	uniprotkb:Q8TAK6	intact:EBI-747035|uniprotkb:Q5XKC1|uniprotkb:Q6NXE9|uniprotkb:Q86YM2|uniprotkb:Q96C88|uniprotkb:Q9H7F7|intact:EBI-2558037|uniprotkb:B4DDR1|ensembl:ENSP00000265807|ensembl:ENSP00000428684	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	psi-mi:sh24a_human(display_long)|uniprotkb:SH2D4A(gene name)|psi-mi:SH2D4A(display_short)|uniprotkb:SH2A(gene name synonym)|uniprotkb:"Protein SH(2)A"(gene name synonym)|uniprotkb:PPP1R38(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 38(gene name synonym)	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697228|imex:IM-22632-362	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001167630.1|refseq:NP_001167631.1|refseq:NP_071354.2|ensembl:ENSG00000104611(gene)|ensembl:ENST00000265807(transcript)|ensembl:ENST00000519207(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019902"(phosphatase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|refseq:NM_001174160.1(identity)|entrezgene/locuslink:63898(identity)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:e7Zi+tTx/rZ4AXx9lSuBz0BmLqI9606	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	intact-crc:B910D6F8255F1D8C|rigid:otbVg4wSxhJ4NCLecUpcqjThho4	false	sufficient binding region:183-454	sufficient binding region:17-271	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZW8	uniprotkb:Q8WVF5	intact:EBI-7543499|intact:MINT-1493010|uniprotkb:Q96JV4|uniprotkb:Q8WV64|uniprotkb:A6NMJ7|uniprotkb:Q71RB7|ensembl:ENSP00000254051	intact:EBI-741463|ensembl:ENSP00000368402|uniprotkb:Q5W0P9	psi-mi:tens4_human(display_long)|uniprotkb:TNS4(gene name)|psi-mi:TNS4(display_short)|uniprotkb:CTEN(gene name synonym)|uniprotkb:PP14434(orf name)|uniprotkb:C-terminal tensin-like protein(gene name synonym)	psi-mi:kctd4_human(display_long)|uniprotkb:KCTD4(gene name)|psi-mi:KCTD4(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697242|imex:IM-22632-363	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116254.4|ensembl:ENSG00000131746(gene)|ensembl:ENST00000254051(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0008104"(protein localization)|interpro:IPR000980(SH2 motif)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR033929|interpro:IPR036860|mint:Q8IZW8|reactome:R-HSA-8875513|refseq:NM_032865.5(identity)|entrezgene/locuslink:84951(identity)	ensembl:ENSG00000180332(gene)|ensembl:ENST00000379108(transcript)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|refseq:NP_940686.2|entrezgene/locuslink:386618(identity)|refseq:NM_198404.2(identity)	-	comment:mint|function:"May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3"	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:k439rXw6HuByQ+t4anCFT0Q23us9606	rogid:03cd1lqmT8fReXzYqjrKSWUdqY89606	intact-crc:813A63143F42579D|rigid:Vjf/w2iV3Fk4UMt6AwIGZuhnDYE	false	sufficient binding region:236-715	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A1A4S6	uniprotkb:Q92625	intact:EBI-1390944|uniprotkb:Q2VPC4|uniprotkb:Q2VPC5|uniprotkb:Q96EV3|uniprotkb:Q96S75|uniprotkb:A1L0S5|ensembl:ENSP00000336923	intact:EBI-1048612|uniprotkb:Q5JYI9|uniprotkb:Q5SYR2|uniprotkb:Q86WQ7|uniprotkb:A2RUC1|ensembl:ENSP00000353518|uniprotkb:B4DQW8	psi-mi:rhg10_human(display_long)|uniprotkb:ARHGAP10(gene name)|psi-mi:ARHGAP10(display_short)|uniprotkb:GRAF2(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 10(gene name synonym)|uniprotkb:GTPase regulator associated with focal adhesion kinase 2(gene name synonym)|uniprotkb:Graf-related protein 2(gene name synonym)	psi-mi:ans1a_human(display_long)|uniprotkb:Odin(gene name synonym)|uniprotkb:ANKS1A(gene name)|psi-mi:ANKS1A(display_short)|uniprotkb:ANKS1(gene name synonym)|uniprotkb:KIAA0229(gene name synonym)|uniprotkb:ODIN(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697254|imex:IM-22632-364	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078881.3|ensembl:ENSG00000071205(gene)|ensembl:ENST00000336498(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|interpro:IPR035485|interpro:IPR035486|interpro:IPR036028|rcsb pdb:2MIO|reactome:R-HSA-211728|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|refseq:XM_005263216.2(identity)|entrezgene/locuslink:79658(identity)	refseq:NP_056060.2|ensembl:ENSG00000064999(gene)|ensembl:ENST00000360359(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0016322"(neuron remodeling)|go:"GO:0043005"(neuron projection)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:1901187"(regulation of ephrin receptor signaling pathway)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR033637|interpro:IPR036770|interpro:IPR041880|interpro:IPR041882|mint:Q92625|rcsb pdb:2LMR|rcsb pdb:2MYQ|rcsb pdb:6F7O|refseq:NM_015245.2(identity)|entrezgene/locuslink:23294(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:gbHj2b+qPHC9tKs3Y3eRicrt8mk9606	rogid:VTw7RU5nIxHSxvQdBUT/YFlQzU89606	intact-crc:256E92BE6AE3488C|rigid:azIEUsltrY+SeXNtL9MWZkaMOdQ	false	sufficient binding region:572-786	sufficient binding region:675-1134	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92625	uniprotkb:Q9UIH9	intact:EBI-1048612|uniprotkb:Q5JYI9|uniprotkb:Q5SYR2|uniprotkb:Q86WQ7|uniprotkb:A2RUC1|ensembl:ENSP00000353518|uniprotkb:B4DQW8	intact:EBI-2796400|ensembl:ENSP00000296233	psi-mi:ans1a_human(display_long)|uniprotkb:Odin(gene name synonym)|uniprotkb:ANKS1A(gene name)|psi-mi:ANKS1A(display_short)|uniprotkb:ANKS1(gene name synonym)|uniprotkb:KIAA0229(gene name synonym)|uniprotkb:ODIN(gene name synonym)	psi-mi:klf15_human(display_long)|uniprotkb:KKLF(gene name synonym)|uniprotkb:Kidney-enriched krueppel-like factor(gene name synonym)|uniprotkb:KLF15(gene name)|psi-mi:KLF15(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697268|imex:IM-22632-365	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056060.2|ensembl:ENSG00000064999(gene)|ensembl:ENST00000360359(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0016322"(neuron remodeling)|go:"GO:0043005"(neuron projection)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:1901187"(regulation of ephrin receptor signaling pathway)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR033637|interpro:IPR036770|interpro:IPR041880|interpro:IPR041882|mint:Q92625|rcsb pdb:2LMR|rcsb pdb:2MYQ|rcsb pdb:6F7O|refseq:NM_015245.2(identity)|entrezgene/locuslink:23294(identity)	refseq:NP_054798.1|refseq:XP_005247457.1|ensembl:ENSG00000163884(gene)|ensembl:ENST00000296233(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016607"(nuclear speck)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9UIH9|rcsb pdb:2ENT|reactome:R-HSA-1368108|entrezgene/locuslink:28999(identity)|refseq:NM_014079.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:VTw7RU5nIxHSxvQdBUT/YFlQzU89606	rogid:vocV1ptKE68rlXylNPMj/4qjo689606	intact-crc:BE28740D5647F2F1|rigid:HP6U0ypVt8jXAblsnog/uGuTmYA	false	sufficient binding region:675-1134	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92625	uniprotkb:Q9H6Z4-3	intact:EBI-1048612|uniprotkb:Q5JYI9|uniprotkb:Q5SYR2|uniprotkb:Q86WQ7|uniprotkb:A2RUC1|ensembl:ENSP00000353518|uniprotkb:B4DQW8	intact:EBI-10697282|ensembl:ENSP00000034275	psi-mi:ans1a_human(display_long)|uniprotkb:Odin(gene name synonym)|uniprotkb:ANKS1A(gene name)|psi-mi:ANKS1A(display_short)|uniprotkb:ANKS1(gene name synonym)|uniprotkb:KIAA0229(gene name synonym)|uniprotkb:ODIN(gene name synonym)	psi-mi:q9h6z4-3(display_long)|uniprotkb:RANBP3(gene name)|psi-mi:RANBP3(display_short)|uniprotkb:Ranbp3-b(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697280|imex:IM-22632-366	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056060.2|ensembl:ENSG00000064999(gene)|ensembl:ENST00000360359(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0016322"(neuron remodeling)|go:"GO:0043005"(neuron projection)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:1901187"(regulation of ephrin receptor signaling pathway)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR033637|interpro:IPR036770|interpro:IPR041880|interpro:IPR041882|mint:Q92625|rcsb pdb:2LMR|rcsb pdb:2MYQ|rcsb pdb:6F7O|refseq:NM_015245.2(identity)|entrezgene/locuslink:23294(identity)	ensembl:ENSG00000031823(gene)|ensembl:ENST00000034275(transcript)|intact:EBI-992681(isoform-parent)|refseq:NM_007320.2(identity)|entrezgene/locuslink:8498(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:VTw7RU5nIxHSxvQdBUT/YFlQzU89606	rogid:6+p38qWekYDJW/6zBD1EJNdVlBM9606	intact-crc:C1EA8D7078207EF2|rigid:Br4I2vLgOKLw4Zn2fWCHFCntukw	false	sufficient binding region:675-1134	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92625	uniprotkb:Q9H3H1-2	intact:EBI-1048612|uniprotkb:Q5JYI9|uniprotkb:Q5SYR2|uniprotkb:Q86WQ7|uniprotkb:A2RUC1|ensembl:ENSP00000353518|uniprotkb:B4DQW8	intact:EBI-10693345	psi-mi:ans1a_human(display_long)|uniprotkb:Odin(gene name synonym)|uniprotkb:ANKS1A(gene name)|psi-mi:ANKS1A(display_short)|uniprotkb:ANKS1(gene name synonym)|uniprotkb:KIAA0229(gene name synonym)|uniprotkb:ODIN(gene name synonym)	psi-mi:q9h3h1-2(display_long)|uniprotkb:tRNA isopentenyltransferase 1(gene name synonym)|uniprotkb:TRIT1(gene name)|psi-mi:TRIT1(display_short)|uniprotkb:IPT(gene name synonym)|uniprotkb:"Isopentenyl-diphosphate:tRNA isopentenyltransferase"(gene name synonym)|uniprotkb:MOD5(gene name synonym)|uniprotkb:hGRO1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697296|imex:IM-22632-367	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056060.2|ensembl:ENSG00000064999(gene)|ensembl:ENST00000360359(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0016322"(neuron remodeling)|go:"GO:0043005"(neuron projection)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:1901187"(regulation of ephrin receptor signaling pathway)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR033637|interpro:IPR036770|interpro:IPR041880|interpro:IPR041882|mint:Q92625|rcsb pdb:2LMR|rcsb pdb:2MYQ|rcsb pdb:6F7O|refseq:NM_015245.2(identity)|entrezgene/locuslink:23294(identity)	intact:EBI-720913(isoform-parent)|refseq:XM_006710706.1(identity)|entrezgene/locuslink:54802(identity)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:VTw7RU5nIxHSxvQdBUT/YFlQzU89606	rogid:99w7Wm+fBfaBVAbobo5LmutMLgg9606	intact-crc:B14BCF19BA662779|rigid:Cr0M4HtOymVgCX5XJdgGqIyWVtI	false	sufficient binding region:675-1134	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96GM5	uniprotkb:Q92625	intact:EBI-358489|intact:EBI-1760001|ensembl:ENSP00000378414|uniprotkb:Q92924|uniprotkb:Q9Y635|intact:EBI-1965109|uniprotkb:A6NN27|intact:EBI-28976725	intact:EBI-1048612|uniprotkb:Q5JYI9|uniprotkb:Q5SYR2|uniprotkb:Q86WQ7|uniprotkb:A2RUC1|ensembl:ENSP00000353518|uniprotkb:B4DQW8	psi-mi:smrd1_human(display_long)|uniprotkb:SMARCD1(gene name)|psi-mi:SMARCD1(display_short)|uniprotkb:BAF60A(gene name synonym)|uniprotkb:SWI/SNF complex 60 kDa subunit(gene name synonym)|uniprotkb:60 kDa BRG-1/Brm-associated factor subunit A(gene name synonym)|uniprotkb:BRG1-associated factor 60A(gene name synonym)	psi-mi:ans1a_human(display_long)|uniprotkb:Odin(gene name synonym)|uniprotkb:ANKS1A(gene name)|psi-mi:ANKS1A(display_short)|uniprotkb:ANKS1(gene name synonym)|uniprotkb:KIAA0229(gene name synonym)|uniprotkb:ODIN(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697308|imex:IM-22632-368	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000066117(gene)|ensembl:ENST00000394963(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048096"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071564"(npBAF complex)|refseq:NP_003067.3|refseq:NP_620710.2|ensembl:ENST00000381513|ensembl:ENSP00000370924|ensembl:ENSP00000378414|go:"GO:0071565"(nBAF complex)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR019835|interpro:IPR036885|interpro:IPR038041|mint:Q96GM5|rcsb pdb:6LTH|rcsb pdb:6LTJ|reactome:R-HSA-3214858|reactome:R-HSA-8939243|dip:DIP-33390N|entrezgene/locuslink:6602(identity)|refseq:NM_003076.4(identity)	refseq:NP_056060.2|ensembl:ENSG00000064999(gene)|ensembl:ENST00000360359(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0016322"(neuron remodeling)|go:"GO:0043005"(neuron projection)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:1901187"(regulation of ephrin receptor signaling pathway)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR033637|interpro:IPR036770|interpro:IPR041880|interpro:IPR041882|mint:Q92625|rcsb pdb:2LMR|rcsb pdb:2MYQ|rcsb pdb:6F7O|refseq:NM_015245.2(identity)|entrezgene/locuslink:23294(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:cwqYnl+J8glG8YjW1ps77Dd105Y9606	rogid:VTw7RU5nIxHSxvQdBUT/YFlQzU89606	intact-crc:97A32575EE3B994F|rigid:68xdcq6ozS4o34A+IpchO84boX4	false	-	sufficient binding region:675-1134	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92625	uniprotkb:Q8NBF2-2	intact:EBI-1048612|uniprotkb:Q5JYI9|uniprotkb:Q5SYR2|uniprotkb:Q86WQ7|uniprotkb:A2RUC1|ensembl:ENSP00000353518|uniprotkb:B4DQW8	intact:EBI-10697320	psi-mi:ans1a_human(display_long)|uniprotkb:Odin(gene name synonym)|uniprotkb:ANKS1A(gene name)|psi-mi:ANKS1A(display_short)|uniprotkb:ANKS1(gene name synonym)|uniprotkb:KIAA0229(gene name synonym)|uniprotkb:ODIN(gene name synonym)	psi-mi:q8nbf2-2(display_long)|uniprotkb:NHLRC2(gene name)|psi-mi:NHLRC2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697324|imex:IM-22632-369	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056060.2|ensembl:ENSG00000064999(gene)|ensembl:ENST00000360359(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0016322"(neuron remodeling)|go:"GO:0043005"(neuron projection)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:1901187"(regulation of ephrin receptor signaling pathway)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR033637|interpro:IPR036770|interpro:IPR041880|interpro:IPR041882|mint:Q92625|rcsb pdb:2LMR|rcsb pdb:2MYQ|rcsb pdb:6F7O|refseq:NM_015245.2(identity)|entrezgene/locuslink:23294(identity)	intact:EBI-10269163(isoform-parent)|uniprotkb:Q8NBF2-2(isoform-parent)|entrezgene/locuslink:374354(identity)|refseq:NM_198514.3(identity)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:VTw7RU5nIxHSxvQdBUT/YFlQzU89606	rogid:SZ0ZDvE3mQJ4RYzHEHcthM2YxCc9606	intact-crc:D726483BD55C8E9F|rigid:kB3/ikKgNSSKvfaQkWL+PwirBSw	false	sufficient binding region:675-1134	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92625	uniprotkb:P06400	intact:EBI-1048612|uniprotkb:Q5JYI9|uniprotkb:Q5SYR2|uniprotkb:Q86WQ7|uniprotkb:A2RUC1|ensembl:ENSP00000353518|uniprotkb:B4DQW8	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	psi-mi:ans1a_human(display_long)|uniprotkb:Odin(gene name synonym)|uniprotkb:ANKS1A(gene name)|psi-mi:ANKS1A(display_short)|uniprotkb:ANKS1(gene name synonym)|uniprotkb:KIAA0229(gene name synonym)|uniprotkb:ODIN(gene name synonym)	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697348|imex:IM-22632-371	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056060.2|ensembl:ENSG00000064999(gene)|ensembl:ENST00000360359(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0016322"(neuron remodeling)|go:"GO:0043005"(neuron projection)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:1901187"(regulation of ephrin receptor signaling pathway)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR033637|interpro:IPR036770|interpro:IPR041880|interpro:IPR041882|mint:Q92625|rcsb pdb:2LMR|rcsb pdb:2MYQ|rcsb pdb:6F7O|refseq:NM_015245.2(identity)|entrezgene/locuslink:23294(identity)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N|entrezgene/locuslink:5925(identity)|refseq:NM_000321.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:VTw7RU5nIxHSxvQdBUT/YFlQzU89606	rogid:xidCNX96KlQzu160polvT61k4Zw9606	intact-crc:EE9D315B1D417930|rigid:14Xi4qbkc0V2EcINMSNc8vol41o	false	sufficient binding region:675-1134	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92625	uniprotkb:Q7L591-3	intact:EBI-1048612|uniprotkb:Q5JYI9|uniprotkb:Q5SYR2|uniprotkb:Q86WQ7|uniprotkb:A2RUC1|ensembl:ENSP00000353518|uniprotkb:B4DQW8	intact:EBI-10694655|ensembl:ENSP00000325174	psi-mi:ans1a_human(display_long)|uniprotkb:Odin(gene name synonym)|uniprotkb:ANKS1A(gene name)|psi-mi:ANKS1A(display_short)|uniprotkb:ANKS1(gene name synonym)|uniprotkb:KIAA0229(gene name synonym)|uniprotkb:ODIN(gene name synonym)	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697336|imex:IM-22632-370	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056060.2|ensembl:ENSG00000064999(gene)|ensembl:ENST00000360359(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0016322"(neuron remodeling)|go:"GO:0043005"(neuron projection)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:1901187"(regulation of ephrin receptor signaling pathway)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR033637|interpro:IPR036770|interpro:IPR041880|interpro:IPR041882|mint:Q92625|rcsb pdb:2LMR|rcsb pdb:2MYQ|rcsb pdb:6F7O|refseq:NM_015245.2(identity)|entrezgene/locuslink:23294(identity)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	-	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:VTw7RU5nIxHSxvQdBUT/YFlQzU89606	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	intact-crc:67430674214507E2|rigid:XKUWh0KtqFTo7731t1Qtl8t/H2Y	false	sufficient binding region:675-1134	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q9UMN6	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-765774|uniprotkb:O15022|uniprotkb:O95836|uniprotkb:Q96GP2|uniprotkb:Q96IP3|uniprotkb:Q9UK25|uniprotkb:Q9Y668|uniprotkb:Q9Y669|ensembl:ENSP00000398837	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:kmt2b_human(display_long)|uniprotkb:KMT2B(gene name)|psi-mi:KMT2B(display_short)|uniprotkb:HRX2(gene name synonym)|uniprotkb:KIAA0304(gene name synonym)|uniprotkb:MLL2(gene name synonym)|uniprotkb:MLL4(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 4(gene name synonym)|uniprotkb:TRX2(gene name synonym)|uniprotkb:Trithorax homolog 2(gene name synonym)|uniprotkb:WBP7(gene name synonym)|uniprotkb:WW domain-binding protein 7(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697360|imex:IM-22632-372	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	ensembl:ENSP00000398837|dip:DIP-34598N|ensembl:ENSG00000272333(gene)|ensembl:ENST00000420124(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|interpro:IPR001214(SET)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR041959|mint:Q9UMN6|rcsb pdb:3UVM|rcsb pdb:4ERZ|rcsb pdb:4PZI|rcsb pdb:7BRE|reactome:R-HSA-3214841|reactome:R-HSA-8936459|entrezgene/locuslink:9757(identity)|refseq:XM_006723515.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:1Im1Dqkyg85ZGqrxLaK4wyMVGNY9606	intact-crc:C0F920F066F1908A|rigid:m6OyfdEfaT9PuW9YCuQ8+rEhQfs	false	-	sufficient binding region:2339..2339-2561..2561	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75052	uniprotkb:P10809	intact:EBI-780467|uniprotkb:B7ZLF5|uniprotkb:Q3T551|uniprotkb:O43564|uniprotkb:Q5VU95|ensembl:ENSP00000355133	intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712	psi-mi:capon_human(display_long)|uniprotkb:C-terminal PDZ ligand of neuronal nitric oxide synthase protein(gene name synonym)|uniprotkb:Nitric oxide synthase 1 adaptor protein(gene name synonym)|uniprotkb:NOS1AP(gene name)|psi-mi:NOS1AP(display_short)|uniprotkb:CAPON(gene name synonym)|uniprotkb:KIAA0464(gene name synonym)	psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697372|imex:IM-22632-373	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119532.2|refseq:NP_001158229.1|refseq:NP_055512.1|ensembl:ENSG00000198929(gene)|ensembl:ENST00000361897(transcript)|go:"GO:0003062"(regulation of heart rate by chemical signal)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903762"(positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:2000170"(positive regulation of peptidyl-cysteine S-nitrosylation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|entrezgene/locuslink:9722(identity)|refseq:NM_014697.2(identity)	refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N|refseq:NM_199440.1(identity)|entrezgene/locuslink:3329(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:bpv0yuTlHR7wYE9SJ4krek2gJXQ9606	rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606	intact-crc:9809356515F00200|rigid:LfcIN5kn7IO7XvaXB/y1PtfsB74	false	-	sufficient binding region:9..9-310..310	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6PJ21	uniprotkb:Q13387	intact:EBI-3937206|uniprotkb:Q96RY2|uniprotkb:Q49A96|uniprotkb:Q96IE6|uniprotkb:Q86X18|uniprotkb:D3DU78|uniprotkb:Q8WXK5|ensembl:ENSP00000301717|ensembl:ENSP00000457206	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:spsb3_human(display_long)|uniprotkb:SPSB3(gene name)|psi-mi:SPSB3(display_short)|uniprotkb:C16orf31(gene name synonym)|uniprotkb:SSB3(gene name synonym)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697384|imex:IM-22632-374	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162032(gene)|ensembl:ENST00000301717(transcript)|ensembl:ENST00000566339(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR035754|interpro:IPR043136|reactome:R-HSA-8951664|refseq:NP_543137.2|refseq:NP_001311010.1|entrezgene/locuslink:90864(identity)|refseq:NM_080861.3(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:c8SHYErijLYY372BuHCcQBrGqBg9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:7916E42843782EB3|rigid:2PoVNBrIX4Z7XFZdwaizsi8YiuU	false	sufficient binding region:252..252-355..355	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5JVS0	uniprotkb:P46108	intact:EBI-523625|uniprotkb:Q8WV33|uniprotkb:Q9NYJ2|intact:EBI-710278|uniprotkb:O75804|intact:EBI-28987425|ensembl:ENSP00000364398	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:habp4_human(display_long)|uniprotkb:Hyaluronan-binding protein 4(gene name synonym)|uniprotkb:HABP4(gene name)|psi-mi:HABP4(display_short)|uniprotkb:Ki-1/57 intracellular antigen(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697396|imex:IM-22632-375	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130956(gene)|ensembl:ENST00000375249(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0015030"(Cajal body)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030017"(sarcomere)|go:"GO:0030578"(PML body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097504"(Gemini of coiled bodies)|interpro:IPR006861(Hyaluronan/mRNA binding protein)|interpro:IPR032381|interpro:IPR039764|mint:Q5JVS0|reactome:R-HSA-114608|refseq:NP_055097.2|ensembl:ENSP00000364398|ensembl:ENST00000375251|ensembl:ENSP00000364400|refseq:XM_005251812.1(identity)|entrezgene/locuslink:22927(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:axioP140qUzhBqAphaVjAlBGxYI9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:63D9670C3E9370CC|rigid:tZdfQ3/8unbfRGQNS7YrSMYJ37w	false	sufficient binding region:164..164-413..413	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14796	uniprotkb:Q05397	intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697408|imex:IM-22632-376	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933|entrezgene/locuslink:117157(identity)|refseq:NM_053282.4(identity)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	intact-crc:9D9EBEC347DC3B85|rigid:a3tJvSERolXx40/wBiysT12qAZs	false	-	sufficient binding region:393..393-1052..1052	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07948	uniprotkb:Q05397	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697420|imex:IM-22632-377	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N|entrezgene/locuslink:4067(identity)|refseq:NM_002350.3(identity)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	intact-crc:3D0B71E3D1EF110B|rigid:JQJyQSx8X6sps5VvAzA9+uQlAZ4	false	-	sufficient binding region:393..393-1052..1052	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12931	uniprotkb:Q05397	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697444|imex:IM-22632-379	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N|refseq:NM_198291.2(identity)|entrezgene/locuslink:6714(identity)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	intact-crc:4D1EE6B6077B9606|rigid:b6Z0Gm87FzZ8ZE5MyUDcVx+ulyo	false	-	sufficient binding region:393..393-1052..1052	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05397	uniprotkb:P08631-2	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	intact:EBI-9834454|ensembl:ENSP00000429848|ensembl:ENSP00000486627	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:p08631-2(display_long)|uniprotkb:p59-HCK(isoform synonym)|uniprotkb:p59Hck(isoform synonym)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697432|imex:IM-22632-378	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	uniprotkb:P08631-2(isoform-parent)|intact:EBI-346340(isoform-parent)|ensembl:ENSG00000101336(gene)|ensembl:ENST00000520553(transcript)|ensembl:ENST00000629881(transcript)|entrezgene/locuslink:3055(identity)|refseq:NM_001172129.1(identity)	-	-	isoform-comment:Initiator Met-1 is removed. Contains a N-myristoyl glycine at position 2. Contains a S-palmitoyl cysteine at position 3.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rogid:qSgfntp+jqdyi7qsc7u7UA7ylO09606	intact-crc:18BC0CAC3EF69C0D|rigid:ZfQA5qGMIi9RPwgRK7r0Ic34qPw	false	sufficient binding region:393..393-1052..1052	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05397	uniprotkb:Q92569	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697456|imex:IM-22632-380	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:0F23D0A7707C2EFF|rigid:m2bZ55O7kwAUUTOTtIuWnCtBjU4	false	sufficient binding region:393..393-1052..1052	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BRG2	uniprotkb:P07199	intact:EBI-2339271|uniprotkb:Q9Y2X4|uniprotkb:B4DRS7|uniprotkb:A8K9R6|intact:EBI-28982569|ensembl:ENSP00000245908	intact:EBI-949451|intact:EBI-28970331|ensembl:ENSP00000369075|uniprotkb:Q96EI4	psi-mi:sh23a_human(display_long)|uniprotkb:SH2D3A(gene name)|psi-mi:SH2D3A(display_short)|uniprotkb:NSP1(gene name synonym)|uniprotkb:Novel SH2-containing protein 1(gene name synonym)|uniprotkb:UNQ175/PRO201(orf name)	psi-mi:cenpb_human(display_long)|uniprotkb:Centromere protein B(gene name synonym)|uniprotkb:CENPB(gene name)|psi-mi:CENPB(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697468|imex:IM-22632-381	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005481.2|refseq:XP_005259529.1|ensembl:ENSP00000245908|ensembl:ENST00000437152|ensembl:ENSP00000393303|ensembl:ENSG00000125731(gene)|ensembl:ENST00000245908(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|interpro:IPR000980(SH2 motif)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR023578|interpro:IPR036860|interpro:IPR036964|interpro:IPR044102|mint:Q9BRG2|refseq:NM_005490.2(identity)|entrezgene/locuslink:10045(identity)	ensembl:ENSP00000369075|ensembl:ENSG00000125817(gene)|ensembl:ENST00000379751(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0016604"(nuclear body)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR004875(CENP-B protein)|interpro:IPR006600(Centromere protein B, helix-turn-helix)|interpro:IPR007889(Helix-turn-helix, Psq)|interpro:IPR009057(Homeodomain-like)|interpro:IPR015115(Centromere protein B dimerisation)|interpro:IPR033062|interpro:IPR034882|mint:P07199|rcsb pdb:1BW6|rcsb pdb:1HLV|rcsb pdb:1UFI|rcsb pdb:6KDR|refseq:NP_001801.1|refseq:NM_001810.5(identity)|entrezgene/locuslink:1059(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8PTqqhIlumS0fnzVS9vJAZPByQQ9606	rogid:+03fJP9KYbjMxvL/JrO0Wj4+MJs9606	intact-crc:6351DF43F1883C38|rigid:N6fcXrUTQYZ3W5W5VyUVlCHuXtc	false	-	sufficient binding region:467..467-599..599	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q9ULJ7	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-5653671|uniprotkb:Q6N064|uniprotkb:A8K4V3|uniprotkb:Q6ZSE6|uniprotkb:B4DHJ6|uniprotkb:E9PDW0|ensembl:ENSP00000425658	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:anr50_human(display_long)|uniprotkb:KIAA1223(gene name synonym)|uniprotkb:ANKRD50(gene name)|psi-mi:ANKRD50(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697480|imex:IM-22632-382	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	dip:DIP-47302N|refseq:NP_001161354.1|refseq:NP_065070.1|refseq:XP_016863960.1|ensembl:ENSG00000151458(gene)|ensembl:ENST00000504087(transcript)|go:"GO:0005768"(endosome)|go:"GO:0015031"(protein transport)|go:"GO:0032456"(endocytic recycling)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q9ULJ7|refseq:NM_001167882.1(identity)|entrezgene/locuslink:57182(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:cP1xkkSlKwersPLj/gvrnWOjm+89606	intact-crc:3588AF1024B1837D|rigid:SMFYC6YVVFDU2QSMv4dz+VYuRpc	false	-	sufficient binding region:687-1429	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43559	uniprotkb:Q9NRF2-2	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	intact:EBI-10691662|ensembl:ENSP00000337163|ensembl:ENSP00000378903	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:q9nrf2-2(display_long)|uniprotkb:SH2B1(gene name)|psi-mi:SH2B1(display_short)|uniprotkb:KIAA1299(gene name synonym)|uniprotkb:Pro-rich, PH and SH2 domain-containing signaling mediator(gene name synonym)|uniprotkb:SH2 domain-containing protein 1B(gene name synonym)|uniprotkb:SH2B(gene name synonym)|uniprotkb:Beta(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697492|imex:IM-22632-383	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	ensembl:ENSG00000178188(gene)|ensembl:ENST00000337120(transcript)|ensembl:ENST00000395532(transcript)|intact:EBI-310491(isoform-parent)|uniprotkb:Q9NRF2-2(isoform-parent)|refseq:NM_001145796.1(identity)|entrezgene/locuslink:25970(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	rogid:5DkSyDavhqIn9glTuxAXN/pKPC09606	intact-crc:5E87F56E63D77E43|rigid:X2xRDJIipPB02Q4+tkUmk6CtB+Q	false	-	sufficient binding region:246-671	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q9NQW6	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-2553589|uniprotkb:Q9H8Y4|uniprotkb:Q6NSK5|uniprotkb:Q9NVP0|uniprotkb:Q9NVN9|uniprotkb:Q5CZ78|ensembl:ENSP00000265748	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:anln_human(display_long)|uniprotkb:ANLN(gene name)|psi-mi:ANLN(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697504|imex:IM-22632-384	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_001271230.1|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030496"(midbody)|go:"GO:0031106"(septin ring organization)|go:"GO:0032059"(bleb)|go:"GO:0045296"(cadherin binding)|go:"GO:0090521"(glomerular visceral epithelial cell migration)|go:"GO:0099738"(cell cortex region)|go:"GO:1904172"(positive regulation of bleb assembly)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012966(Protein of unknown function DUF1709, fungi)|interpro:IPR031970|interpro:IPR037840|rcsb pdb:2Y7B|rcsb pdb:4XH3|rcsb pdb:4XOI|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000011426(gene)|ensembl:ENST00000265748(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0000921"(septin ring assembly)|go:"GO:0003779"(actin binding)|refseq:NP_001271231.1|refseq:NP_061155.2|entrezgene/locuslink:54443(identity)|refseq:NM_001284302.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:QemfgJ3tP6xprJozjv41SoVzLdU9606	intact-crc:4BF3A3CB7640E109|rigid:KMttGshDCJA7SVvhBhQDWqbF700	false	-	sufficient binding region:720-1124	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43559	uniprotkb:Q9HBL0-2	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	intact:EBI-10697516|ensembl:ENSP00000308321	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:q9hbl0-2(display_long)|uniprotkb:TNS1(gene name)|psi-mi:TNS1(display_short)|uniprotkb:TNS(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697520|imex:IM-22632-385	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	ensembl:ENSG00000079308(gene)|ensembl:ENST00000310858(transcript)|intact:EBI-3389814(isoform-parent)|entrezgene/locuslink:7145(identity)|refseq:NM_022648.4(identity)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	rogid:Sfb9Ht37MeopY4TJ/WRkbOJRnYw9606	intact-crc:BBEDA9902B92B45E|rigid:LqSc/GByJUWArGdcd8S5lizZrUE	false	-	sufficient binding region:14-382	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BY12	uniprotkb:Q9UKG1	intact:EBI-308519|uniprotkb:Q3B7X7|uniprotkb:Q96BS9|uniprotkb:Q9H3D8|uniprotkb:Q9NT03|uniprotkb:Q9P274|ensembl:ENSP00000326924|ensembl:ENSP00000454973|uniprotkb:F5H7X8|uniprotkb:H3BNR7	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:scape_human(display_long)|uniprotkb:SCAPER(gene name)|psi-mi:SCAPER(display_short)|uniprotkb:KIAA1454(gene name synonym)|uniprotkb:ZNF291(gene name synonym)|uniprotkb:Zinc finger protein 291(gene name synonym)|uniprotkb:MSTP063(orf name)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697532|imex:IM-22632-386	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140386(gene)|ensembl:ENST00000324767(transcript)|ensembl:ENST00000563290(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016607"(nuclear speck)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR032446|interpro:IPR036236|refseq:NP_001139395.1|refseq:NP_065894.2|refseq:XP_005254476.1|refseq:XP_016877758.1|refseq:XP_016877759.1|entrezgene/locuslink:49855(identity)|refseq:NM_001145923.1(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:HR+n9xkgNCLpYBSb/pQ52Er6aqU9606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:982E5789841A2568|rigid:WWnJVakuesH7aZHPQoh9T8c6Z2A	false	sufficient binding region:1109-1400	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:Q9BXJ4	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-10697546|uniprotkb:Q96KY1|uniprotkb:Q542Y2|uniprotkb:Q0VAN4|uniprotkb:Q6MZN1|ensembl:ENSP00000231338	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:c1qt3_human(display_long)|uniprotkb:C1QTNF3(gene name)|psi-mi:C1QTNF3(display_short)|uniprotkb:CTRP3(gene name synonym)|uniprotkb:Collagenous repeat-containing sequence 26 kDa protein(gene name synonym)|uniprotkb:Secretory protein CORS26(gene name synonym)|uniprotkb:UNQ753/PRO1484(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697544|imex:IM-22632-387	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	refseq:NP_112207.1|refseq:NP_852100.3|ensembl:ENST00000231338(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005581"(collagen trimer)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070165"(positive regulation of adiponectin secretion)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|ensembl:ENSG00000082196(gene)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|entrezgene/locuslink:114899(identity)|refseq:NM_030945.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:/L5yDneAjdNz8bJVwGe1TlKN12g9606	intact-crc:CA0FEA2F60CA3DCE|rigid:2yc619C/SMDpYqoBOyUy7Bl9Scc	false	-	sufficient binding region:121-246	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14796	uniprotkb:Q8TAK6	intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym)	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697564|imex:IM-22632-388	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933|entrezgene/locuslink:117157(identity)|refseq:NM_053282.4(identity)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	intact-crc:39800A495CD5B972|rigid:6IP/ELSX2myGNdMemehffrOFpkU	false	-	sufficient binding region:17-271	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60880	uniprotkb:Q8TAK6	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697576|imex:IM-22632-389	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N|entrezgene/locuslink:4068(identity)|refseq:NM_002351.4(identity)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	intact-crc:CA2DBD1EB5ABDA36|rigid:LToSjd9RWR3BeKN/ovNM3vFBSF0	false	-	sufficient binding region:17-271	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08631-2	uniprotkb:Q8TAK6	intact:EBI-9834454|ensembl:ENSP00000429848|ensembl:ENSP00000486627	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	psi-mi:p08631-2(display_long)|uniprotkb:p59-HCK(isoform synonym)|uniprotkb:p59Hck(isoform synonym)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697588|imex:IM-22632-390	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:P08631-2(isoform-parent)|intact:EBI-346340(isoform-parent)|ensembl:ENSG00000101336(gene)|ensembl:ENST00000520553(transcript)|ensembl:ENST00000629881(transcript)|entrezgene/locuslink:3055(identity)|refseq:NM_001172129.1(identity)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	-	isoform-comment:Initiator Met-1 is removed. Contains a N-myristoyl glycine at position 2. Contains a S-palmitoyl cysteine at position 3.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:qSgfntp+jqdyi7qsc7u7UA7ylO09606	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	intact-crc:319C7A7AEE4AC659|rigid:YQAeJdSPVk5bACbPibOzufXNRtc	false	-	sufficient binding region:17-271	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q8TAK6	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697600|imex:IM-22632-391	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	intact-crc:AF27981A05825FD9|rigid:PLCL9VFYUYx0ZtcJqbzLeAkTfP4	false	-	sufficient binding region:17-271	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TAK6	uniprotkb:Q8TEW6	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	intact:EBI-6918542|ensembl:ENSP00000344277|ensembl:ENSP00000455128|uniprotkb:O75209|uniprotkb:Q9BTP2|uniprotkb:Q9NVV3	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:dok4_human(display_long)|uniprotkb:DOK4(gene name)|psi-mi:DOK4(display_short)|uniprotkb:Downstream of tyrosine kinase 4(gene name synonym)|uniprotkb:Insulin receptor substrate 5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697612|imex:IM-22632-392	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	ensembl:ENSG00000125170(gene)|ensembl:ENST00000340099(transcript)|ensembl:ENST00000569548(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0043410"(positive regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_060580.2|refseq:XP_005256100.1|entrezgene/locuslink:55715(identity)|refseq:NM_018110.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	rogid:Xc4aPsHtdQKj02Q5cqqgw29pSS09606	intact-crc:D6B0CA5F66D913E5|rigid:bEP6OsmT4ezRp3FUiBaeDhUNtto	false	sufficient binding region:17-271	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TAK6	uniprotkb:Q92569	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697624|imex:IM-22632-393	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:56C5DA7F5E84A926|rigid:uklMzAGeiMzEZqjSar17I3AbQCE	false	sufficient binding region:17-271	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TAK6	uniprotkb:Q96IW2	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	intact:EBI-4402781|uniprotkb:Q96NC2|ensembl:ENSP00000446058	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:shd_human(display_long)|uniprotkb:SHD(gene name)|psi-mi:SHD(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697636|imex:IM-22632-394	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	refseq:NP_064594.3|ensembl:ENSG00000105251(gene)|go:"GO:0001784"(phosphotyrosine residue binding)|interpro:IPR000980(SH2 motif)|interpro:IPR035039|interpro:IPR035046|interpro:IPR036860|ensembl:ENST00000543264(transcript)|entrezgene/locuslink:56961(identity)|refseq:NM_020209.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	rogid:c2PsXxVdBB1dLj+Lu40XdgOb2yY9606	intact-crc:246CC2A7A34A78C1|rigid:MnBuqKBYdpUy65W2KANLsmd5Fdg	false	sufficient binding region:17-271	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96JZ2	uniprotkb:Q8TAK6	intact:EBI-3919324|intact:EBI-28973686|ensembl:ENSP00000482604|ensembl:ENSP00000483354|uniprotkb:B5ME72|uniprotkb:Q6ZNG7	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	psi-mi:hsh2d_human(display_long)|uniprotkb:HSH2D(gene name)|psi-mi:HSH2D(display_short)|uniprotkb:ALX(gene name synonym)|uniprotkb:Adaptor in lymphocytes of unknown function X(gene name synonym)	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697648|imex:IM-22632-395	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000483354|ensembl:ENSP00000482604|ensembl:ENSG00000196684(gene)|ensembl:ENST00000613986(transcript)|ensembl:ENST00000616645(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR035047|interpro:IPR036860|rcsb pdb:2CS0|go:"GO:0005737"(cytoplasm)|refseq:NP_116244.1|refseq:NP_001278203.1|refseq:NM_032855.3(identity)|entrezgene/locuslink:84941(identity)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Y01YjkfU/oOtbz2TdQcnm+lBWhs9606	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	intact-crc:D265185C20E7D6FC|rigid:zGC4kYZsca4cgnj1VMGEydnvlDY	false	-	sufficient binding region:17-271	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P104-2	uniprotkb:Q8TAK6	intact:EBI-10692909|ensembl:ENSP00000379270	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	psi-mi:q9p104-2(display_long)|uniprotkb:DOK5(gene name)|psi-mi:DOK5(display_short)|uniprotkb:C20orf180(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 5(gene name synonym)|uniprotkb:Insulin receptor substrate 6(gene name synonym)	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697660|imex:IM-22632-396	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101134(gene)|ensembl:ENST00000395939(transcript)|intact:EBI-739600(isoform-parent)|uniprotkb:Q9P104-2(isoform-parent)|refseq:NM_177959.2(identity)|entrezgene/locuslink:55816(identity)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8p18JpE/uszPiQyb4FtcEu5QiOc9606	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	intact-crc:2071A116F70E6650|rigid:M2ch3ey8auXWYss5pG/NKUvkTxo	false	-	sufficient binding region:17-271	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N5Z5	uniprotkb:P16885	intact:EBI-743960|uniprotkb:B0QYA9|uniprotkb:B0QYB0|uniprotkb:O95517|ensembl:ENSP00000385096	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	psi-mi:kcd17_human(display_long)|uniprotkb:KCTD17(gene name)|psi-mi:KCTD17(display_short)	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697672|imex:IM-22632-397	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269613.1|refseq:NP_001269614.1|refseq:NP_001269615.1|refseq:NP_078957.2|ensembl:ENSG00000100379(gene)|ensembl:ENST00000403888(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030030"(cell projection organization)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q8N5Z5|rcsb pdb:5A6R|entrezgene/locuslink:79734(identity)|refseq:NM_001282684.1(identity)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:998kw0bw9dTtZQYgdqYCNxIKG0w9606	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	intact-crc:1389AF774A300042|rigid:C/5C/VnjJZcG3WtaGoVdYKHw8Gs	false	sufficient binding region:8-321	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N5Z5	uniprotkb:P46108	intact:EBI-743960|uniprotkb:B0QYA9|uniprotkb:B0QYB0|uniprotkb:O95517|ensembl:ENSP00000385096	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:kcd17_human(display_long)|uniprotkb:KCTD17(gene name)|psi-mi:KCTD17(display_short)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697684|imex:IM-22632-398	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269613.1|refseq:NP_001269614.1|refseq:NP_001269615.1|refseq:NP_078957.2|ensembl:ENSG00000100379(gene)|ensembl:ENST00000403888(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030030"(cell projection organization)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q8N5Z5|rcsb pdb:5A6R|entrezgene/locuslink:79734(identity)|refseq:NM_001282684.1(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:998kw0bw9dTtZQYgdqYCNxIKG0w9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:55A156D24A11BC91|rigid:B/lwHJe31pCVlUf2LRW/+RxUF5g	false	sufficient binding region:8-321	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TB24	uniprotkb:Q8N5Z5	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	intact:EBI-743960|uniprotkb:B0QYA9|uniprotkb:B0QYB0|uniprotkb:O95517|ensembl:ENSP00000385096	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:kcd17_human(display_long)|uniprotkb:KCTD17(gene name)|psi-mi:KCTD17(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697696|imex:IM-22632-399	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	refseq:NP_001269613.1|refseq:NP_001269614.1|refseq:NP_001269615.1|refseq:NP_078957.2|ensembl:ENSG00000100379(gene)|ensembl:ENST00000403888(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030030"(cell projection organization)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q8N5Z5|rcsb pdb:5A6R|entrezgene/locuslink:79734(identity)|refseq:NM_001282684.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	rogid:998kw0bw9dTtZQYgdqYCNxIKG0w9606	intact-crc:BE920754348E8C79|rigid:NbEimCIptq9qaCd55ZFn2GRl2xk	false	-	sufficient binding region:8-321	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16885	uniprotkb:Q7L3V2	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	intact:EBI-10697720|uniprotkb:A8K5E7|uniprotkb:Q6MZM8|uniprotkb:D3DX21|uniprotkb:Q9H7A0|uniprotkb:Q6N000|ensembl:ENSP00000330596|ensembl:ENSP00000384924|ensembl:ENSP00000386111	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:bop_human(display_long)|uniprotkb:RTL10(gene name)|psi-mi:RTL10(display_short)|uniprotkb:BH3-only protein(gene name synonym)|uniprotkb:BOP(gene name synonym)|uniprotkb:C22orf29(gene name synonym)|uniprotkb:Retrotransposon Gag-like protein 10(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697729|imex:IM-22632-401	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	refseq:NP_078903.3|ensembl:ENSG00000215012(gene)|ensembl:ENST00000328554(transcript)|ensembl:ENST00000405640(transcript)|ensembl:ENST00000407472(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|interpro:IPR031298|interpro:IPR032549|interpro:IPR032567|refseq:NM_024627.5(identity)|entrezgene/locuslink:79680(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	rogid:3OMCFcqFyAV6hOyclERyLuKQEF89606	intact-crc:076572A09EC08C64|rigid:8gqGhfJGPJe+DC4tl/W4yx4vFrw	false	-	sufficient binding region:62-364	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZQ1	uniprotkb:Q92569	intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697708|imex:IM-22632-400	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N|refseq:NM_014991.4(identity)|entrezgene/locuslink:23001(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:4678B782474D95DA|rigid:spVanlkejP4ktZ7uCwuaIskEdFY	false	sufficient binding region:3246-3526	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q66PJ3-4	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-5280499	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:q66pj3-4(display_long)|uniprotkb:Splicing factor SRrp37(gene name synonym)|uniprotkb:ARL6IP4(gene name)|psi-mi:ARL6IP4(display_short)|uniprotkb:HSP-975(gene name synonym)|uniprotkb:HSVI-binding protein(gene name synonym)|uniprotkb:SR-15(gene name synonym)|uniprotkb:SRp25(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697741|imex:IM-22632-402	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	intact:EBI-2683099(isoform-parent)|uniprotkb:Q66PJ3-4(isoform-parent)|entrezgene/locuslink:51329(identity)|refseq:NM_001002252.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:XZT/eX9V6PNVyIyUg7RvZpH0Ydg9606	intact-crc:2CF7459B8B61A2D6|rigid:hw+8a5B8+s66k/rniQ0tqk4KyY4	false	-	sufficient binding region:185-399	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q5SZD1	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-10697767|uniprotkb:Q8N400|uniprotkb:A8K1H4|uniprotkb:Q96NQ1|ensembl:ENSP00000431184|ensembl:ENSP00000434602|ensembl:ENSP00000436754	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:cf141_human(display_long)|uniprotkb:C6orf141(gene name)|psi-mi:C6orf141(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697765|imex:IM-22632-404	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_001139124.1|refseq:XP_005248907.1|refseq:XP_005248909.1|refseq:XP_005248910.1|refseq:XP_006715060.1|refseq:XP_011512605.1|ensembl:ENSG00000197261(gene)|ensembl:ENST00000371194(transcript)|ensembl:ENST00000414696(transcript)|ensembl:ENST00000529246(transcript)|go:"GO:0001835"(blastocyst hatching)|interpro:IPR037739|refseq:XP_016865783.1|refseq:XP_016865784.1|refseq:XP_016865785.1|refseq:XP_016865786.1|refseq:XP_016865787.1|refseq:NM_001145652.1(identity)|entrezgene/locuslink:135398(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:hp8gRS5//S8kmZWEsJTI9pYUu0o9606	intact-crc:25014A3D7DA18E7F|rigid:s3G2s+ZE2/5rdN++CnLwLjZstT4	false	-	sufficient binding region:8-244	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P104-2	uniprotkb:Q5TGY3	intact:EBI-10692909|ensembl:ENSP00000379270	intact:EBI-948813|ensembl:ENSP00000247087|ensembl:ENSP00000363123|ensembl:ENSP00000494394|ensembl:ENSP00000495072|ensembl:ENSP00000495665|ensembl:ENSP00000501218|uniprotkb:Q5TGY4|uniprotkb:Q6PJK1|uniprotkb:Q6ZUQ6|uniprotkb:Q99769|uniprotkb:Q9NUF5	psi-mi:q9p104-2(display_long)|uniprotkb:DOK5(gene name)|psi-mi:DOK5(display_short)|uniprotkb:C20orf180(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 5(gene name synonym)|uniprotkb:Insulin receptor substrate 6(gene name synonym)	psi-mi:ahdc1_human(display_long)|uniprotkb:AHDC1(gene name)|psi-mi:AHDC1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697753|imex:IM-22632-403	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101134(gene)|ensembl:ENST00000395939(transcript)|intact:EBI-739600(isoform-parent)|uniprotkb:Q9P104-2(isoform-parent)|refseq:NM_177959.2(identity)|entrezgene/locuslink:55816(identity)	ensembl:ENSG00000126705(gene)|ensembl:ENST00000247087(transcript)|ensembl:ENST00000374011(transcript)|ensembl:ENST00000642245(transcript)|ensembl:ENST00000642416(transcript)|ensembl:ENST00000644989(transcript)|ensembl:ENST00000673934(transcript)|go:"GO:0003677"(DNA binding)|interpro:IPR032757|interpro:IPR039225|mint:Q5TGY3|refseq:NP_001025053.1|refseq:XP_011539557.1|refseq:XP_011539558.1|refseq:XP_011539559.1|refseq:XP_005245905.1|refseq:XP_005245906.1|refseq:XP_005245907.1|refseq:XP_005245908.1|refseq:XP_005245909.1|entrezgene/locuslink:27245(identity)|refseq:NM_001029882.3(identity)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8p18JpE/uszPiQyb4FtcEu5QiOc9606	rogid:lYUJEAEhxO204mZnqOd4Vf6K/g89606	intact-crc:8743E61B2E3AADFC|rigid:OUCHTI+9oEI5wrP4V6gepNhEsxU	false	-	sufficient binding region:1205-1603	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5SZD1	uniprotkb:Q12929	intact:EBI-10697767|uniprotkb:Q8N400|uniprotkb:A8K1H4|uniprotkb:Q96NQ1|ensembl:ENSP00000431184|ensembl:ENSP00000434602|ensembl:ENSP00000436754	intact:EBI-375576|uniprotkb:A6NMC3|ensembl:ENSP00000281172|ensembl:ENSP00000441867|ensembl:ENSP00000442388|ensembl:ENSP00000494689|ensembl:ENSP00000494842|ensembl:ENSP00000495722|ensembl:ENSP00000495824|ensembl:ENSP00000495956|ensembl:ENSP00000496406|ensembl:ENSP00000496516|uniprotkb:Q8N6J0|uniprotkb:B4DX66|uniprotkb:A8K6W2|uniprotkb:A8KA66	psi-mi:cf141_human(display_long)|uniprotkb:C6orf141(gene name)|psi-mi:C6orf141(display_short)	psi-mi:eps8_human(display_long)|uniprotkb:EPS8(gene name)|psi-mi:EPS8(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697784|imex:IM-22632-405	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139124.1|refseq:XP_005248907.1|refseq:XP_005248909.1|refseq:XP_005248910.1|refseq:XP_006715060.1|refseq:XP_011512605.1|ensembl:ENSG00000197261(gene)|ensembl:ENST00000371194(transcript)|ensembl:ENST00000414696(transcript)|ensembl:ENST00000529246(transcript)|go:"GO:0001835"(blastocyst hatching)|interpro:IPR037739|refseq:XP_016865783.1|refseq:XP_016865784.1|refseq:XP_016865785.1|refseq:XP_016865786.1|refseq:XP_016865787.1|refseq:NM_001145652.1(identity)|entrezgene/locuslink:135398(identity)	ensembl:ENST00000645775(transcript)|ensembl:ENST00000646828(transcript)|ensembl:ENSG00000151491(gene)|ensembl:ENST00000646918(transcript)|ensembl:ENST00000647087(transcript)|ensembl:ENST00000647224(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010458"(exit from mitosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0030426"(growth cone)|go:"GO:0030832"(regulation of actin filament length)|go:"GO:0031267"(small GTPase binding)|ensembl:ENST00000281172(transcript)|ensembl:ENST00000543523(transcript)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|ensembl:ENST00000543612(transcript)|ensembl:ENST00000642278(transcript)|ensembl:ENST00000644374(transcript)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030222|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q12929|rcsb pdb:2E8M|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_004438.3|dip:DIP-32859N|entrezgene/locuslink:2059(identity)|refseq:NM_004447.5(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:hp8gRS5//S8kmZWEsJTI9pYUu0o9606	rogid:ulBgb+4uZ7XrN4bLogRtd9I5AbY9606	intact-crc:3C90BD44BCA2025A|rigid:xdbFl0e5lkdyBymw+ce/Ll/EXPs	false	sufficient binding region:8-244	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49757-3	uniprotkb:Q15554	intact:EBI-10692196|ensembl:ENSP00000352563|ensembl:ENSP00000451117	intact:EBI-706637|ensembl:ENSP00000254942|intact:EBI-706651	psi-mi:p49757-3(display_long)|uniprotkb:C14orf41(gene name synonym)|uniprotkb:NUMB(gene name)|psi-mi:NUMB(display_short)|uniprotkb:Protein S171(gene name synonym)|uniprotkb:p71(isoform synonym)	psi-mi:terf2_human(display_long)|uniprotkb:TTAGGG repeat-binding factor 2(gene name synonym)|uniprotkb:Telomeric DNA-binding protein(gene name synonym)|uniprotkb:TERF2(gene name)|psi-mi:TERF2(display_short)|uniprotkb:TRF2(gene name synonym)|uniprotkb:TRBF2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697796|imex:IM-22632-406	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-915016(isoform-parent)|uniprotkb:P49757-3(isoform-parent)|ensembl:ENSG00000133961(gene)|ensembl:ENST00000359560(transcript)|ensembl:ENST00000557597(transcript)|entrezgene/locuslink:8650(identity)|refseq:NM_001005745.1(identity)	go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032208"(negative regulation of telomere maintenance via recombination)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032214"(negative regulation of telomere maintenance via semi-conservative replication)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0090398"(cellular senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:0099087"(anterograde axonal transport of messenger ribonucleoprotein complex)|go:"GO:1903770"(negative regulation of beta-galactosidase activity)|go:"GO:1903824"(negative regulation of telomere single strand break repair)|go:"GO:1904115"(axon cytoplasm)|go:"GO:0032205"(negative regulation of telomere maintenance)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|ensembl:ENSG00000132604(gene)|ensembl:ENST00000254942(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031627"(telomeric loop formation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR030657|interpro:IPR031902|interpro:IPR036507|mint:Q15554|rcsb pdb:1H6P|rcsb pdb:1VF9|rcsb pdb:1VFC|rcsb pdb:1W0U|rcsb pdb:1XG1|rcsb pdb:3BU8|rcsb pdb:3BUA|rcsb pdb:3K6G|rcsb pdb:3SJM|rcsb pdb:4M7C|rcsb pdb:4RQI|rcsb pdb:5WQD|rcsb pdb:5XYF|rcsb pdb:6J67|rcsb pdb:7C5D|reactome:R-HSA-110328|reactome:R-HSA-110329|go:"GO:1904354"(negative regulation of telomere capping)|refseq:NP_005643.2|dip:DIP-34052N|refseq:XM_005256123.1(identity)|entrezgene/locuslink:7014(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:N2YwdjNBMiXeMFYxQrJDxqeNkSA9606	rogid:MzPf3uCpzJzkIKvgaP0Xro7xnHo9606	intact-crc:12883E2F3E188C02|rigid:RFtEVq0njoRhK96NSMzn8m7QWjw	false	-	sufficient binding region:43-280	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q15554	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-706637|ensembl:ENSP00000254942|intact:EBI-706651	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:terf2_human(display_long)|uniprotkb:TTAGGG repeat-binding factor 2(gene name synonym)|uniprotkb:Telomeric DNA-binding protein(gene name synonym)|uniprotkb:TERF2(gene name)|psi-mi:TERF2(display_short)|uniprotkb:TRF2(gene name synonym)|uniprotkb:TRBF2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697808|imex:IM-22632-407	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032208"(negative regulation of telomere maintenance via recombination)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032214"(negative regulation of telomere maintenance via semi-conservative replication)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0090398"(cellular senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:0099087"(anterograde axonal transport of messenger ribonucleoprotein complex)|go:"GO:1903770"(negative regulation of beta-galactosidase activity)|go:"GO:1903824"(negative regulation of telomere single strand break repair)|go:"GO:1904115"(axon cytoplasm)|go:"GO:0032205"(negative regulation of telomere maintenance)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|ensembl:ENSG00000132604(gene)|ensembl:ENST00000254942(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031627"(telomeric loop formation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR030657|interpro:IPR031902|interpro:IPR036507|mint:Q15554|rcsb pdb:1H6P|rcsb pdb:1VF9|rcsb pdb:1VFC|rcsb pdb:1W0U|rcsb pdb:1XG1|rcsb pdb:3BU8|rcsb pdb:3BUA|rcsb pdb:3K6G|rcsb pdb:3SJM|rcsb pdb:4M7C|rcsb pdb:4RQI|rcsb pdb:5WQD|rcsb pdb:5XYF|rcsb pdb:6J67|rcsb pdb:7C5D|reactome:R-HSA-110328|reactome:R-HSA-110329|go:"GO:1904354"(negative regulation of telomere capping)|refseq:NP_005643.2|dip:DIP-34052N|refseq:XM_005256123.1(identity)|entrezgene/locuslink:7014(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:MzPf3uCpzJzkIKvgaP0Xro7xnHo9606	intact-crc:2D02A442B41A6910|rigid:ALEQWFvYN+i1uGVXis+8fq2QHrc	false	-	sufficient binding region:43-280	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:Q14435	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-10697820|uniprotkb:Q7Z476|uniprotkb:Q53TG9|ensembl:ENSP00000376465	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:galt3_human(display_long)|uniprotkb:GALNT3(gene name)|psi-mi:GALNT3(display_short)|uniprotkb:Polypeptide GalNAc transferase 3(gene name synonym)|uniprotkb:Protein-UDP acetylgalactosaminyltransferase 3(gene name synonym)|uniprotkb:"UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3"(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697826|imex:IM-22632-408	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	refseq:NP_004473.2|refseq:XP_005246506.1|refseq:XP_011509231.1|ensembl:ENSG00000115339(gene)|ensembl:ENST00000392701(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004653"(polypeptide N-acetylgalactosaminyltransferase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016266"(O-glycan processing)|go:"GO:0018242"(protein O-linked glycosylation via serine)|go:"GO:0018243"(protein O-linked glycosylation via threonine)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001173(Glycosyl transferase, family 2)|interpro:IPR029044|interpro:IPR035992|reactome:R-HSA-190372|reactome:R-HSA-5083625|reactome:R-HSA-913709|refseq:XP_016859259.1|refseq:XM_006712402.1(identity)|entrezgene/locuslink:2591(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:ctuWH3RUp0sYoXZl0G0gyZoQ8609606	intact-crc:8CE7974A3BDB5124|rigid:7he1sJ5efb3Q6rQym6+nbsgkScw	false	-	sufficient binding region:52-171	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:Q03989	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-948603|ensembl:ENSP00000350078|intact:EBI-10176351|intact:EBI-15316505|uniprotkb:C9J1Q0|uniprotkb:Q6NX37	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:ari5a_human(display_long)|uniprotkb:Modulator recognition factor 1(gene name synonym)|uniprotkb:ARID5A(gene name)|psi-mi:ARID5A(display_short)|uniprotkb:MRF1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697838|imex:IM-22632-409	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	ensembl:ENSG00000196843(gene)|ensembl:ENST00000357485(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071391"(cellular response to estrogen stimulus)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR036431|mint:Q03989|uniprotkb:Q03989-2(uniprot-removed-ac)|refseq:NP_997646.1|refseq:NP_001306021.1|refseq:XM_005263860.1(identity)|entrezgene/locuslink:10865(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2017/06/29	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:Zi6YxDBLmiIe852L2PlAAdCj7Dg9606	intact-crc:0596A8C844F0A0C1|rigid:zUkTJsbcMVlvMDAYhyOdwDaOgQ0	false	-	sufficient binding region:165-594	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:P17252	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-1383528|uniprotkb:Q96RE4|uniprotkb:Q15137|uniprotkb:Q32M72|uniprotkb:B5BU22|ensembl:ENSP00000408695	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:kpca_human(display_long)|uniprotkb:PRKCA(gene name)|psi-mi:PRKCA(display_short)|uniprotkb:PKCA(gene name synonym)|uniprotkb:PRKACA(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697850|imex:IM-22632-410	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	refseq:NP_002728.1|dip:DIP-531N|ensembl:ENSG00000154229(gene)|ensembl:ENST00000413366(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002159"(desmosome assembly)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000707"(positive regulation of dense core granule biogenesis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034663|interpro:IPR035892|mint:P17252|rcsb pdb:2ELI|rcsb pdb:3IW4|rcsb pdb:4DNL|rcsb pdb:4RA4|reactome:R-HSA-111933|reactome:R-HSA-114516|reactome:R-HSA-1250196|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2179392|reactome:R-HSA-2514859|reactome:R-HSA-3000170|reactome:R-HSA-399997|reactome:R-HSA-4086398|reactome:R-HSA-416993|reactome:R-HSA-418597|reactome:R-HSA-4419969|reactome:R-HSA-450520|reactome:R-HSA-5099900|go:"GO:0043488"(regulation of mRNA stability)|reactome:R-HSA-5668599|reactome:R-HSA-76005|reactome:R-HSA-8853659|reactome:R-HSA-9010642|reactome:R-HSA-5218921|refseq:NM_002737.2(identity)|entrezgene/locuslink:5578(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:VW6o9vP7DTAQT2W9hEmyCLjoEX09606	intact-crc:E8E831985D286AE6|rigid:Ss00Cy/+92//ofTXhnvFQWIrWaI	false	-	sufficient binding region:330-672	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75052	uniprotkb:P06241	intact:EBI-780467|uniprotkb:B7ZLF5|uniprotkb:Q3T551|uniprotkb:O43564|uniprotkb:Q5VU95|ensembl:ENSP00000355133	intact:EBI-515315|uniprotkb:Q16248|uniprotkb:Q5R3A6|uniprotkb:Q5R3A7|uniprotkb:Q8N5D7|uniprotkb:B5BU57|intact:EBI-2561531|uniprotkb:E1P557|uniprotkb:H0UI48|ensembl:ENSP00000346671|ensembl:ENSP00000357656	psi-mi:capon_human(display_long)|uniprotkb:C-terminal PDZ ligand of neuronal nitric oxide synthase protein(gene name synonym)|uniprotkb:Nitric oxide synthase 1 adaptor protein(gene name synonym)|uniprotkb:NOS1AP(gene name)|psi-mi:NOS1AP(display_short)|uniprotkb:CAPON(gene name synonym)|uniprotkb:KIAA0464(gene name synonym)	psi-mi:fyn_human(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697862|imex:IM-22632-411	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119532.2|refseq:NP_001158229.1|refseq:NP_055512.1|ensembl:ENSG00000198929(gene)|ensembl:ENST00000361897(transcript)|go:"GO:0003062"(regulation of heart rate by chemical signal)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903762"(positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:2000170"(positive regulation of peptidyl-cysteine S-nitrosylation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|entrezgene/locuslink:9722(identity)|refseq:NM_014697.2(identity)	refseq:XP_005266947.1|refseq:XP_005266949.1|refseq:NP_002028.1|refseq:NP_694592.1|refseq:NP_694593.1|refseq:XP_016866139.1|refseq:XP_016866140.1|refseq:XP_016866141.1|refseq:XP_016866142.1|refseq:XP_016866143.1|dip:DIP-33876N|ensembl:ENSG00000010810(gene)|ensembl:ENST00000354650(transcript)|ensembl:ENST00000368667(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001764"(neuron migration)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0003015"(heart process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007612"(learning)|go:"GO:0007631"(feeding behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|interpro:IPR036028|interpro:IPR036860|mint:P06241|rcsb pdb:1A0N|rcsb pdb:1AOT|rcsb pdb:1AOU|rcsb pdb:1AVZ|rcsb pdb:1AZG|rcsb pdb:1EFN|rcsb pdb:1FYN|rcsb pdb:1G83|rcsb pdb:1M27|rcsb pdb:1NYF|rcsb pdb:1NYG|rcsb pdb:1SHF|rcsb pdb:1ZBJ|rcsb pdb:2DQ7|rcsb pdb:2MQI|rcsb pdb:2MRJ|rcsb pdb:2MRK|rcsb pdb:3H0F|rcsb pdb:3H0H|rcsb pdb:3H0I|rcsb pdb:3UA6|rcsb pdb:3UA7|rcsb pdb:4D8D|rcsb pdb:4EIK|rcsb pdb:4U17|rcsb pdb:4U1P|rcsb pdb:4ZNX|rcsb pdb:5ZAU|rcsb pdb:6EDF|rcsb pdb:6IPY|rcsb pdb:6IPZ|reactome:R-HSA-114604|reactome:R-HSA-1227986|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5621480|reactome:R-HSA-5621575|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-75892|reactome:R-HSA-8866376|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9706374|reactome:R-HSA-983695|reactome:R-HSA-9670439|entrezgene/locuslink:2534(identity)|refseq:NM_002037.5(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:bpv0yuTlHR7wYE9SJ4krek2gJXQ9606	rogid:GM5wIXENkJgPKwHN+UZBIqUfH6U9606	intact-crc:A63D8812680BC591|rigid:hw6+po7P/5AgYHrKF9E/FqjaF9M	false	-	sufficient binding region:115-537	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02741	uniprotkb:Q13387	intact:EBI-1395983|uniprotkb:A8K078|uniprotkb:Q08AK3|uniprotkb:Q8WW75|uniprotkb:D3DVD9|uniprotkb:D3DVE0|ensembl:ENSP00000255030	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:crp_human(display_long)|uniprotkb:CRP(gene name)|psi-mi:CRP(display_short)|uniprotkb:PTX1(gene name synonym)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697874|imex:IM-22632-412	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000558.2|refseq:NP_001315986.1|refseq:NP_001315987.1|dip:DIP-39125N|ensembl:ENSG00000132693(gene)|ensembl:ENST00000255030(transcript)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008228"(opsonization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0032677"(regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0033265"(choline binding)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0045087"(innate immune response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|mint:P02741|rcsb pdb:1B09|rcsb pdb:1CRV|rcsb pdb:1GNH|rcsb pdb:1LJ7|rcsb pdb:3L2Y|rcsb pdb:3PVN|rcsb pdb:3PVO|reactome:R-HSA-173623|entrezgene/locuslink:1401(identity)|refseq:NM_000567.2(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:R7vKMSGKD4ETbUKVGL9IiL8jzjE9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:CFCF190C8010AC32|rigid:iS8IyxKDHw/PSPu8TKJGJryMoWE	false	sufficient binding region:179-224	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00459	uniprotkb:Q9UKG1	intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697898|imex:IM-22632-414	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409|entrezgene/locuslink:5296(identity)|refseq:NM_005027.3(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:58B21FECE07B2E0B|rigid:AvXxjML+XnB7wUBE6lOluM+o/Sc	false	sufficient binding region:476-728	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:O15460-2	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-10182841|ensembl:ENSP00000353772|ensembl:ENSP00000368379|ensembl:ENSP00000368394	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:o15460-2(display_long)|uniprotkb:Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2(gene name synonym)|uniprotkb:UNQ290/PRO330(orf name)|uniprotkb:P4HA2(gene name)|psi-mi:P4HA2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697886|imex:IM-22632-413	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	ensembl:ENSG00000072682(gene)|ensembl:ENST00000360568(transcript)|ensembl:ENST00000379086(transcript)|ensembl:ENST00000379100(transcript)|intact:EBI-348033(isoform-parent)|uniprotkb:O15460-2(isoform-parent)|refseq:NM_001017974.1(identity)|entrezgene/locuslink:8974(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:YndwsjPs3tNpYhzRLkuABcY2+549606	intact-crc:677C99C3303AA380|rigid:kWXJ86Q2YOCH/zd3KktrzY94P/E	false	-	sufficient binding region:30-533	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96RY7	uniprotkb:P46108	intact:EBI-308494|uniprotkb:O60332|uniprotkb:Q9UG52|uniprotkb:A2A2A8|uniprotkb:D3DU75|ensembl:ENSP00000406012	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:if140_human(display_long)|uniprotkb:IFT140(gene name)|psi-mi:IFT140(display_short)|uniprotkb:KIAA0590(gene name synonym)|uniprotkb:WDTC2(gene name synonym)|uniprotkb:WD and tetratricopeptide repeats protein 2(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697922|imex:IM-22632-416	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055529.2|ensembl:ENSG00000187535(gene)|ensembl:ENST00000426508(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0021532"(neural tube patterning)|go:"GO:0030991"(intraciliary transport particle A)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:1990403"(embryonic brain development)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|reactome:R-HSA-5610787|reactome:R-HSA-5620924|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0097542"(ciliary tip)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1905515"(non-motile cilium assembly)|refseq:XP_006721053.1|refseq:XP_006721054.1|refseq:XP_016879399.1|entrezgene/locuslink:9742(identity)|refseq:NM_014714.3(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:LQ8zt35IhriM/UbIOoQXk72oLAQ9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:E206FA01BB00B5C0|rigid:0CiEdyjWrqJWv2zggc0C0vNTcO4	false	sufficient binding region:723-1036	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q9H8Y5	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-724848|uniprotkb:Q9NVZ4|intact:EBI-28979360|ensembl:ENSP00000321617|ensembl:ENSP00000386337	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:ankz1_human(display_long)|uniprotkb:Zinc finger protein 744(gene name synonym)|uniprotkb:ANKZF1(gene name)|psi-mi:ANKZF1(display_short)|uniprotkb:ZNF744(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697910|imex:IM-22632-415	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_001035869.1|refseq:NP_060559.2|ensembl:ENSP00000321617|ensembl:ENSP00000386337|ensembl:ENSG00000163516(gene)|ensembl:ENST00000323348(transcript)|ensembl:ENST00000410034(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|interpro:IPR002110(Ankyrin)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036770|interpro:IPR041175|interpro:IPR041540|refseq:NM_001282792.1(identity)|entrezgene/locuslink:55139(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:ddIMBu8TTSoqw3EFEPgqx+F0BHA9606	intact-crc:0B3218C1AE7EF0B7|rigid:FzOY72tqAaWFK8ffb6/yvenvJWo	false	-	sufficient binding region:538-726	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43559	uniprotkb:Q59E92	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	intact:EBI-2826251	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:q59e92_human(display_long)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697934|imex:IM-22632-417	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	go:"GO:0003676"(nucleic acid binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016787"(hydrolase activity)|interpro:IPR027417|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|entrezgene/locuslink:1655(identity)|refseq:NM_004396.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	rogid:lmFoW+c6jfVgtFe8D1Co3RNeB9M9606	intact-crc:FDE5C414DDF54633|rigid:CJRTgY2mbTzjLOD1OE2HgNqIrS8	false	-	sufficient binding region:32-227	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96JZ2	uniprotkb:Q07912	intact:EBI-3919324|intact:EBI-28973686|ensembl:ENSP00000482604|ensembl:ENSP00000483354|uniprotkb:B5ME72|uniprotkb:Q6ZNG7	intact:EBI-603457|intact:EBI-1384159|uniprotkb:Q6ZMQ0|uniprotkb:Q8N6U7|uniprotkb:Q96H59|ensembl:ENSP00000329425	psi-mi:hsh2d_human(display_long)|uniprotkb:HSH2D(gene name)|psi-mi:HSH2D(display_short)|uniprotkb:ALX(gene name synonym)|uniprotkb:Adaptor in lymphocytes of unknown function X(gene name synonym)	psi-mi:ack1_human(display_long)|uniprotkb:ACK1(gene name synonym)|uniprotkb:TNK2(gene name)|psi-mi:TNK2(display_short)|uniprotkb:Tyrosine kinase non-receptor protein 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697958|imex:IM-22632-419	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000483354|ensembl:ENSP00000482604|ensembl:ENSG00000196684(gene)|ensembl:ENST00000613986(transcript)|ensembl:ENST00000616645(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR035047|interpro:IPR036860|rcsb pdb:2CS0|go:"GO:0005737"(cytoplasm)|refseq:NP_116244.1|refseq:NP_001278203.1|refseq:NM_032855.3(identity)|entrezgene/locuslink:84941(identity)	ensembl:ENSP00000329425|ensembl:ENST00000439230|ensembl:ENSP00000395588|ensembl:ENST00000671753|ensembl:ENSP00000499858|ensembl:ENSG00000061938(gene)|ensembl:ENST00000333602(transcript)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006897"(endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050699"(WW domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0097268"(cytoophidium)|go:"GO:0106310"(protein serine kinase activity)|refseq:NP_001010938.1|refseq:NP_005772.3|refseq:NP_001294975.1|dip:DIP-33858N|go:"GO:0106311"|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015116(GTPase binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR021619|interpro:IPR030220|interpro:IPR036028|interpro:IPR037085|mint:Q07912|rcsb pdb:1CF4|rcsb pdb:1U46|rcsb pdb:1U4D|rcsb pdb:1U54|rcsb pdb:3EQP|rcsb pdb:3EQR|rcsb pdb:4EWH|rcsb pdb:4HZR|rcsb pdb:4HZS|rcsb pdb:4ID7|rcsb pdb:5ZXB|rcsb pdb:6VQM|entrezgene/locuslink:10188(identity)|refseq:XM_006713468.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Y01YjkfU/oOtbz2TdQcnm+lBWhs9606	rogid:AD7D+7w6zZOL3VHmf23YSk6NW2w9606	intact-crc:0A3CFB7FA68EB907|rigid:ozwU1fa2uuF+W7UD0+aelsBJfBk	false	-	sufficient binding region:1-484	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q53HF2	uniprotkb:Q13387	intact:EBI-877761	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:q53hf2_human(display_long)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697946|imex:IM-22632-418	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|refseq:NP_006588.1|refseq:NP_694881.1|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR043129|refseq:NM_153201.3(identity)|entrezgene/locuslink:3303(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:m6Qk8kbAwVk7YILzmsVDpzKHUvE9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:724471D4C570CA59|rigid:Ajvkjg2E/rcWSLUO5M0cGM6Ey4o	false	sufficient binding region:12-203	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15069	uniprotkb:P40763	intact:EBI-7108375|intact:EBI-28985682|ensembl:ENSP00000420477|intact:MINT-8247385	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:nacad_human(display_long)|uniprotkb:NACAD(gene name)|psi-mi:NACAD(display_short)|uniprotkb:KIAA0363(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697982|imex:IM-22632-421	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000420477|ensembl:ENSG00000136274(gene)|ensembl:ENST00000490531(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005854"(nascent polypeptide-associated complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002715(Nascent polypeptide-associated complex NAC)|interpro:IPR016641(Nascent polypeptide-associated complex, alpha subunit)|interpro:IPR038187|interpro:IPR041907|interpro:IPR044034|mint:O15069|refseq:NP_001139806.1|entrezgene/locuslink:23148(identity)|refseq:NM_001146334.1(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	comment:mint|comment:homomint	crc64:6C00632211C8012D	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3D2LzjKH2eMMhWI0fR5GKIgm5P49606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:156E3E909C7C2F7E|rigid:Bm8jcvNxlYruErPJaXZ//DmUGHM	false	sufficient binding region:1086-1350	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P104-2	uniprotkb:O95785	intact:EBI-10692909|ensembl:ENSP00000379270	intact:EBI-1387294|uniprotkb:B7ZM82|uniprotkb:Q4G0E0|uniprotkb:Q6P6B0|uniprotkb:Q6ZN24|uniprotkb:Q7LDY6|uniprotkb:Q7LDZ1|uniprotkb:Q96IG5|uniprotkb:Q96SQ6|uniprotkb:Q9BUR8|uniprotkb:Q9NPT1|intact:EBI-10967552|uniprotkb:B3KVH1|uniprotkb:M0QY21	psi-mi:q9p104-2(display_long)|uniprotkb:DOK5(gene name)|psi-mi:DOK5(display_short)|uniprotkb:C20orf180(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 5(gene name synonym)|uniprotkb:Insulin receptor substrate 6(gene name synonym)	psi-mi:wiz_human(display_long)|uniprotkb:WIZ(gene name)|psi-mi:WIZ(display_short)|uniprotkb:ZNF803(gene name synonym)|uniprotkb:Widely-interspaced zinc finger-containing protein(gene name synonym)|uniprotkb:Zinc finger protein 803(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10697970|imex:IM-22632-420	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101134(gene)|ensembl:ENST00000395939(transcript)|intact:EBI-739600(isoform-parent)|uniprotkb:Q9P104-2(isoform-parent)|refseq:NM_177959.2(identity)|entrezgene/locuslink:55816(identity)	refseq:NP_067064.2|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|refseq:NP_001317324.1|interpro:IPR036236|mint:O95785|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|go:"GO:0030496"(midbody)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990226"(histone methyltransferase binding)|refseq:XM_005260007.2(identity)|entrezgene/locuslink:58525(identity)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8p18JpE/uszPiQyb4FtcEu5QiOc9606	rogid:FMQwuMDlEC/Zdsnayyl7kpQSmyg9606	intact-crc:05D0F04595810017|rigid:ciCILquO/Y9riy+8EhPxAgOQAb4	false	-	sufficient binding region:547-839	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P104-2	uniprotkb:Q9Y5P3	intact:EBI-10692909|ensembl:ENSP00000379270	intact:EBI-746228|uniprotkb:Q8N6X7|uniprotkb:B1B1K2|ensembl:ENSP00000333456|ensembl:ENSP00000353106|ensembl:ENSP00000401323|ensembl:ENSP00000444210|uniprotkb:B4DQM9|uniprotkb:E7EMN4	psi-mi:q9p104-2(display_long)|uniprotkb:DOK5(gene name)|psi-mi:DOK5(display_short)|uniprotkb:C20orf180(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 5(gene name synonym)|uniprotkb:Insulin receptor substrate 6(gene name synonym)	psi-mi:rai2_human(display_long)|uniprotkb:RAI2(gene name)|psi-mi:RAI2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698021|imex:IM-22632-424	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101134(gene)|ensembl:ENST00000395939(transcript)|intact:EBI-739600(isoform-parent)|uniprotkb:Q9P104-2(isoform-parent)|refseq:NM_177959.2(identity)|entrezgene/locuslink:55816(identity)	refseq:NP_001166214.1|refseq:XP_011543741.1|refseq:XP_011543742.1|refseq:XP_011543743.1|ensembl:ENSG00000131831(gene)|ensembl:ENST00000331511(transcript)|ensembl:ENST00000360011(transcript)|ensembl:ENST00000451717(transcript)|ensembl:ENST00000545871(transcript)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|interpro:IPR026092|mint:Q9Y5P3|refseq:NP_001166203.1|refseq:XP_006724522.1|refseq:XP_006724523.1|refseq:NP_001166210.1|refseq:NP_068557.3|entrezgene/locuslink:10742(identity)|refseq:NM_021785.4(identity)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8p18JpE/uszPiQyb4FtcEu5QiOc9606	rogid:cQ4QQAp6lbQjIvn9xzXPRfUBEzo9606	intact-crc:DEF5BE00C6A6784C|rigid:bplZD4duPjWBhEmK+73bmtm4ZsM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEU8	uniprotkb:Q9Y5P3	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	intact:EBI-746228|uniprotkb:Q8N6X7|uniprotkb:B1B1K2|ensembl:ENSP00000333456|ensembl:ENSP00000353106|ensembl:ENSP00000401323|ensembl:ENSP00000444210|uniprotkb:B4DQM9|uniprotkb:E7EMN4	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:rai2_human(display_long)|uniprotkb:RAI2(gene name)|psi-mi:RAI2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698011|imex:IM-22632-423	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	refseq:NP_001166214.1|refseq:XP_011543741.1|refseq:XP_011543742.1|refseq:XP_011543743.1|ensembl:ENSG00000131831(gene)|ensembl:ENST00000331511(transcript)|ensembl:ENST00000360011(transcript)|ensembl:ENST00000451717(transcript)|ensembl:ENST00000545871(transcript)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|interpro:IPR026092|mint:Q9Y5P3|refseq:NP_001166203.1|refseq:XP_006724522.1|refseq:XP_006724523.1|refseq:NP_001166210.1|refseq:NP_068557.3|entrezgene/locuslink:10742(identity)|refseq:NM_021785.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	rogid:cQ4QQAp6lbQjIvn9xzXPRfUBEzo9606	intact-crc:61B9BE353A4F6CE0|rigid:GdeNQrdeKxGbb80ZUYMp1puXX4Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TB24	uniprotkb:Q9Y6A2	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	intact:EBI-10697994|uniprotkb:E7EQG9|uniprotkb:B4DHP8|uniprotkb:Q8N2B0|ensembl:ENSP00000261835	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:cp46a_human(display_long)|uniprotkb:CYP46A1(gene name)|psi-mi:CYP46A1(display_short)|uniprotkb:CYP46(gene name synonym)|uniprotkb:Cytochrome P450 46A1(gene name synonym)|uniprotkb:Cholesterol 24-monooxygenase(gene name synonym)|uniprotkb:Cholesterol 24S-hydroxylase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698001|imex:IM-22632-422	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	refseq:NP_006659.1|ensembl:ENSG00000036530(gene)|ensembl:ENST00000261835(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0030425"(dendrite)|go:"GO:0033781"(cholesterol 24-hydroxylase activity)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0062184"(testosterone 16-beta-hydroxylase activity)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1903044"(protein localization to membrane raft)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR017972|interpro:IPR036396|interpro:IPR039983|rcsb pdb:2Q9F|rcsb pdb:2Q9G|rcsb pdb:3MDM|rcsb pdb:3MDR|rcsb pdb:3MDT|rcsb pdb:3MDV|rcsb pdb:4ENH|rcsb pdb:4FIA|rcsb pdb:4J14|reactome:R-HSA-193775|reactome:R-HSA-211976|entrezgene/locuslink:10858(identity)|refseq:NM_006668.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	rogid:Oui7tClqfeg1rP3Yxb5f+cRMpZ09606	intact-crc:8EADD37839D2648B|rigid:TI8vrx9rksq6H6zJ5httQF08Or4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q9Y4E5	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-747230|uniprotkb:Q5VVF1|uniprotkb:Q8N380|uniprotkb:Q8TD15|uniprotkb:Q9NQM1|uniprotkb:Q86YE4|uniprotkb:Q9C0G1|intact:EBI-1104831|uniprotkb:Q5VVE9|ensembl:ENSP00000359740	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:zn451_human(display_long)|uniprotkb:KIAA1702(gene name synonym)|uniprotkb:Coactivator for steroid receptors(gene name synonym)|uniprotkb:ZNF451(gene name)|psi-mi:ZNF451(display_short)|uniprotkb:COASTER(gene name synonym)|uniprotkb:KIAA0576(gene name synonym)|uniprotkb:Zinc finger protein 451(gene name synonym)|uniprotkb:E3 SUMO-protein transferase ZNF451(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698041|imex:IM-22632-426	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_001026794.1|refseq:NP_056370.2|ensembl:ENSG00000112200(gene)|ensembl:ENST00000370706(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0060633"(negative regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:2000616"(negative regulation of histone H3-K9 acetylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR041192|mint:Q9Y4E5|rcsb pdb:5D2M|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|dip:DIP-51264N|refseq:XM_005248994.1(identity)|entrezgene/locuslink:26036(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:WNBXLe+XYJ7nSNhgXZL3keG5OYo9606	intact-crc:151AF8DB3CD33E2C|rigid:aoFyse4JxJr+W7CvrgKI0uieFpY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y575	uniprotkb:Q8TB24	intact:EBI-2875625|ensembl:ENSP00000263634|ensembl:ENSP00000385085|uniprotkb:Q53TN8|uniprotkb:Q53TN0|uniprotkb:B3KPA3|uniprotkb:Q9NVZ2|uniprotkb:D6W5B4|uniprotkb:D6W5B5|uniprotkb:G8JLA9|uniprotkb:Q2TAI4	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	psi-mi:asb3_human(display_long)|uniprotkb:ASB3(gene name)|psi-mi:ASB3(display_short)	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698031|imex:IM-22632-425	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030315"(T-tubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0055117"(regulation of cardiac muscle contraction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036036|interpro:IPR036770|interpro:IPR037329|mint:Q9Y575|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000115239(gene)|ensembl:ENST00000263634(transcript)|ensembl:ENST00000406625(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|refseq:NP_001188894.1|refseq:NP_057199.1|refseq:NP_665862.1|refseq:NP_001157637.1|refseq:NM_016115.4(identity)|entrezgene/locuslink:51130(identity)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:gIMKRtUzf90UdaMhaSwEmesN+KE9606	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	intact-crc:32B9293C82151988|rigid:RoVsuhmnrB+5nUoFYtm86o5HcxU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12929	uniprotkb:Q9UQB8	intact:EBI-375576|uniprotkb:A6NMC3|ensembl:ENSP00000281172|ensembl:ENSP00000441867|ensembl:ENSP00000442388|ensembl:ENSP00000494689|ensembl:ENSP00000494842|ensembl:ENSP00000495722|ensembl:ENSP00000495824|ensembl:ENSP00000495956|ensembl:ENSP00000496406|ensembl:ENSP00000496516|uniprotkb:Q8N6J0|uniprotkb:B4DX66|uniprotkb:A8K6W2|uniprotkb:A8KA66	intact:EBI-525456|uniprotkb:O43858|uniprotkb:Q53HB1|uniprotkb:Q86WC1|uniprotkb:Q8N5C0|uniprotkb:Q96CR7|uniprotkb:Q9UBR3|uniprotkb:Q9UQ43|ensembl:ENSP00000316338	psi-mi:eps8_human(display_long)|uniprotkb:EPS8(gene name)|psi-mi:EPS8(display_short)	psi-mi:baip2_human(display_long)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Insulin receptor substrate p53/p58(gene name synonym)|uniprotkb:Fas ligand-associated factor 3(gene name synonym)|uniprotkb:BAIAP2(gene name)|psi-mi:BAIAP2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698075|imex:IM-22632-429	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000645775(transcript)|ensembl:ENST00000646828(transcript)|ensembl:ENSG00000151491(gene)|ensembl:ENST00000646918(transcript)|ensembl:ENST00000647087(transcript)|ensembl:ENST00000647224(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010458"(exit from mitosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0030426"(growth cone)|go:"GO:0030832"(regulation of actin filament length)|go:"GO:0031267"(small GTPase binding)|ensembl:ENST00000281172(transcript)|ensembl:ENST00000543523(transcript)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|ensembl:ENST00000543612(transcript)|ensembl:ENST00000642278(transcript)|ensembl:ENST00000644374(transcript)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030222|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q12929|rcsb pdb:2E8M|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_004438.3|dip:DIP-32859N|entrezgene/locuslink:2059(identity)|refseq:NM_004447.5(identity)	refseq:NP_001138360.1|refseq:NP_006331.1|refseq:NP_059344.1|refseq:NP_059345.1|refseq:XP_005257005.1|dip:DIP-29272N|go:"GO:0009617"(response to bacterium)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q9UQB8|rcsb pdb:1WDZ|rcsb pdb:1Y2O|rcsb pdb:2YKT|rcsb pdb:3RNJ|rcsb pdb:4JS0|rcsb pdb:6BCR|rcsb pdb:6BCY|rcsb pdb:6BD1|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6ZEG|rcsb pdb:6ZEI|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9664422|ensembl:ENSG00000175866(gene)|ensembl:ENST00000321300(transcript)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008360"(regulation of cell shape)|refseq:NM_001144888.1(identity)|entrezgene/locuslink:10458(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ulBgb+4uZ7XrN4bLogRtd9I5AbY9606	rogid:BRbjAYBnAJN0Pzb7bc/Qtb4w5bY9606	intact-crc:7FAF104AC1B6BFD2|rigid:8+tee7zIHGHABJiispPtuQR3Ly0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UQB8-6	uniprotkb:Q12929	intact:EBI-9092016	intact:EBI-375576|uniprotkb:A6NMC3|ensembl:ENSP00000281172|ensembl:ENSP00000441867|ensembl:ENSP00000442388|ensembl:ENSP00000494689|ensembl:ENSP00000494842|ensembl:ENSP00000495722|ensembl:ENSP00000495824|ensembl:ENSP00000495956|ensembl:ENSP00000496406|ensembl:ENSP00000496516|uniprotkb:Q8N6J0|uniprotkb:B4DX66|uniprotkb:A8K6W2|uniprotkb:A8KA66	psi-mi:q9uqb8-6(display_long)|uniprotkb:Fas ligand-associated factor 3(gene name synonym)|uniprotkb:Insulin receptor substrate p53/p58(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:BAIAP2(gene name)|psi-mi:BAIAP2(display_short)	psi-mi:eps8_human(display_long)|uniprotkb:EPS8(gene name)|psi-mi:EPS8(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698065|imex:IM-22632-428	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-525456(isoform-parent)|uniprotkb:Q9UQB8-6(isoform-parent)|refseq:XM_005256948.1(identity)|entrezgene/locuslink:10458(identity)	ensembl:ENST00000645775(transcript)|ensembl:ENST00000646828(transcript)|ensembl:ENSG00000151491(gene)|ensembl:ENST00000646918(transcript)|ensembl:ENST00000647087(transcript)|ensembl:ENST00000647224(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010458"(exit from mitosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0030426"(growth cone)|go:"GO:0030832"(regulation of actin filament length)|go:"GO:0031267"(small GTPase binding)|ensembl:ENST00000281172(transcript)|ensembl:ENST00000543523(transcript)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|ensembl:ENST00000543612(transcript)|ensembl:ENST00000642278(transcript)|ensembl:ENST00000644374(transcript)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030222|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q12929|rcsb pdb:2E8M|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_004438.3|dip:DIP-32859N|entrezgene/locuslink:2059(identity)|refseq:NM_004447.5(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:n2iqdXaDCA6aLxGI9wl3/44N3ws9606	rogid:ulBgb+4uZ7XrN4bLogRtd9I5AbY9606	intact-crc:4547C25B95716268|rigid:a1yVCaA+kRBv7XLDLoWLGtD3oNo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q9Y483-4	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-10698053|ensembl:ENSP00000359326	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:q9y483-4(display_long)|uniprotkb:MTF2(gene name)|psi-mi:MTF2(display_short)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:PCL2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698051|imex:IM-22632-427	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	intact:EBI-725816(isoform-parent)|ensembl:ENSG00000143033(gene)|ensembl:ENST00000370303(transcript)|uniprotkb:Q9Y483-4(isoform-parent)|entrezgene/locuslink:22823(identity)|refseq:NM_001164392.1(identity)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2018/04/06	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:Vx7Nb8FxvF073Zd5X/JAF18S+ss9606	intact-crc:5D4019622981F3BB|rigid:Wsaicqxevb3iyCDXbbMzAjGmee8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UPG8	uniprotkb:O75052	intact:EBI-2876622|ensembl:ENSP00000246229|uniprotkb:Q92584|uniprotkb:A8K8T5|uniprotkb:E1P5M3	intact:EBI-780467|uniprotkb:B7ZLF5|uniprotkb:Q3T551|uniprotkb:O43564|uniprotkb:Q5VU95|ensembl:ENSP00000355133	psi-mi:plal2_human(display_long)|uniprotkb:PLAGL2(gene name)|psi-mi:PLAGL2(display_short)|uniprotkb:KIAA0198(gene name synonym)|uniprotkb:Pleiomorphic adenoma-like protein 2(gene name synonym)	psi-mi:capon_human(display_long)|uniprotkb:C-terminal PDZ ligand of neuronal nitric oxide synthase protein(gene name synonym)|uniprotkb:Nitric oxide synthase 1 adaptor protein(gene name synonym)|uniprotkb:NOS1AP(gene name)|psi-mi:NOS1AP(display_short)|uniprotkb:CAPON(gene name synonym)|uniprotkb:KIAA0464(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698095|imex:IM-22632-431	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000126003(gene)|ensembl:ENST00000246229(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009791"(post-embryonic development)|go:"GO:0034378"(chylomicron assembly)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR027765|interpro:IPR036236|go:"GO:0006629"(lipid metabolic process)|refseq:XP_011527165.1|refseq:XP_011527166.1|refseq:NP_002648.1|refseq:XP_005260493.1|refseq:NM_002657.3(identity)|entrezgene/locuslink:5326(identity)	refseq:NP_001119532.2|refseq:NP_001158229.1|refseq:NP_055512.1|ensembl:ENSG00000198929(gene)|ensembl:ENST00000361897(transcript)|go:"GO:0003062"(regulation of heart rate by chemical signal)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903762"(positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:2000170"(positive regulation of peptidyl-cysteine S-nitrosylation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|entrezgene/locuslink:9722(identity)|refseq:NM_014697.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ccN33kK/lnKGSE4G3rJ/TvkIEE09606	rogid:bpv0yuTlHR7wYE9SJ4krek2gJXQ9606	intact-crc:3121F6C3A54737C4|rigid:c1y92wU56ODRHCsZuWlwm4Ka7QA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UPY8	uniprotkb:Q8TEW6	intact:EBI-726739|uniprotkb:O00265|uniprotkb:Q6FI15|uniprotkb:Q9BZP7|uniprotkb:Q9BZP8|uniprotkb:B7WPK5|uniprotkb:Q6FHB0|ensembl:ENSP00000233121	intact:EBI-6918542|ensembl:ENSP00000344277|ensembl:ENSP00000455128|uniprotkb:O75209|uniprotkb:Q9BTP2|uniprotkb:Q9NVV3	psi-mi:mare3_human(display_long)|uniprotkb:End-binding protein 3(gene name synonym)|uniprotkb:EB1 protein family member 3(gene name synonym)|uniprotkb:RP3(gene name synonym)|uniprotkb:MAPRE3(gene name)|psi-mi:MAPRE3(display_short)	psi-mi:dok4_human(display_long)|uniprotkb:DOK4(gene name)|psi-mi:DOK4(display_short)|uniprotkb:Downstream of tyrosine kinase 4(gene name synonym)|uniprotkb:Insulin receptor substrate 5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698085|imex:IM-22632-430	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036458.2|refseq:XP_016859086.1|refseq:NP_001289979.1|refseq:XP_006712030.1|refseq:XP_011531002.1|dip:DIP-56069N|ensembl:ENSG00000084764(gene)|ensembl:ENST00000233121(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042802"(identical protein binding)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:1903033"(positive regulation of microtubule plus-end binding)|go:"GO:1904825"(protein localization to microtubule plus-end)|go:"GO:1905721"(mitotic spindle astral microtubule end)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR004953(EB1, C-terminal)|interpro:IPR027328|interpro:IPR027738|interpro:IPR036133|interpro:IPR036872|mint:Q9UPY8|rcsb pdb:1WYO|rcsb pdb:3CO1|rcsb pdb:3JAK|rcsb pdb:3JAL|rcsb pdb:3JAR|rcsb pdb:3TQ7|refseq:NM_012326.2(identity)|entrezgene/locuslink:22924(identity)	ensembl:ENSG00000125170(gene)|ensembl:ENST00000340099(transcript)|ensembl:ENST00000569548(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0043410"(positive regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_060580.2|refseq:XP_005256100.1|entrezgene/locuslink:55715(identity)|refseq:NM_018110.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:LHuufxyNrygS3iFW5mmg13R43NE9606	rogid:Xc4aPsHtdQKj02Q5cqqgw29pSS09606	intact-crc:1354D7A72713748D|rigid:M+LTdzMCJo6NEwhIz/kaCQWkxaw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:Q9UM13	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-1266437|uniprotkb:Q2V500|uniprotkb:Q9UG51|uniprotkb:Q9Y5R0|uniprotkb:D3DNZ7|ensembl:ENSP00000310071|ensembl:ENSP00000403891|ensembl:ENSP00000423995|ensembl:ENSP00000478501	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:apc10_human(display_long)|uniprotkb:ANAPC10(gene name)|psi-mi:ANAPC10(display_short)|uniprotkb:APC10(gene name synonym)|uniprotkb:Cyclosome subunit 10(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698125|imex:IM-22632-434	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	refseq:NP_055700.2|refseq:NP_001305296.1|refseq:NP_001243635.1|refseq:NP_001243636.1|refseq:NP_001243637.1|refseq:NP_001243638.1|refseq:NP_001243639.1|refseq:XP_011529826.1|dip:DIP-39885N|ensembl:ENSG00000164162(gene)|ensembl:ENST00000309439(transcript)|ensembl:ENST00000451299(transcript)|ensembl:ENST00000507656(transcript)|ensembl:ENST00000613466(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR016901(Anaphase-promoting complex, subunit 10, subgroup)|mint:Q9UM13|rcsb pdb:1JHJ|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|rcsb pdb:6TLJ|refseq:NM_014885.4(identity)|entrezgene/locuslink:10393(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:kKLo92DrTuOsaeowcNSWKe7xyn49606	intact-crc:0AF396A55150F012|rigid:LJe2cTZbM9i53UixoXHqHZK0CjM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UNL4	uniprotkb:Q13387	intact:EBI-2866661|uniprotkb:Q9H3J0|uniprotkb:Q96E15|uniprotkb:Q4VBQ6|uniprotkb:D3DUR8|uniprotkb:A4KYM4|uniprotkb:Q0EF62|uniprotkb:Q0EF63|uniprotkb:A4KYM6|ensembl:ENSP00000380024	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:ing4_human(display_long)|uniprotkb:ING4(gene name)|psi-mi:ING4(display_short)|uniprotkb:p29ING4(gene name synonym)|uniprotkb:My036(orf name)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698115|imex:IM-22632-433	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121054.1|refseq:NP_001121055.1|refseq:NP_001121056.1|refseq:NP_001121057.1|refseq:NP_001121058.1|refseq:NP_057246.2|dip:DIP-42222N|ensembl:ENSG00000111653(gene)|ensembl:ENST00000396807(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006473"(protein acetylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043983"(histone H4-K12 acetylation)|interpro:IPR028651|mint:Q9UNL4|rcsb pdb:2K1J|rcsb pdb:2M1R|rcsb pdb:2PNX|rcsb pdb:2VNF|rcsb pdb:4AFL|reactome:R-HSA-3214847|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR024610|interpro:IPR028638|refseq:NM_001127582.1(identity)|entrezgene/locuslink:51147(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:71DYqPEISrr06/kbSTCdA3J23NU9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:2FA9E3F6ED110E0E|rigid:low8ykT0CHGXla465jQy4xtI60c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UN19	uniprotkb:Q9UPG8	intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602	intact:EBI-2876622|ensembl:ENSP00000246229|uniprotkb:Q92584|uniprotkb:A8K8T5|uniprotkb:E1P5M3	psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name)	psi-mi:plal2_human(display_long)|uniprotkb:PLAGL2(gene name)|psi-mi:PLAGL2(display_short)|uniprotkb:KIAA0198(gene name synonym)|uniprotkb:Pleiomorphic adenoma-like protein 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698105|imex:IM-22632-432	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695|entrezgene/locuslink:27071(identity)|refseq:NM_014395.2(identity)	ensembl:ENSG00000126003(gene)|ensembl:ENST00000246229(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009791"(post-embryonic development)|go:"GO:0034378"(chylomicron assembly)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR027765|interpro:IPR036236|go:"GO:0006629"(lipid metabolic process)|refseq:XP_011527165.1|refseq:XP_011527166.1|refseq:NP_002648.1|refseq:XP_005260493.1|refseq:NM_002657.3(identity)|entrezgene/locuslink:5326(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:YYI49xKbndaB1MfL/QEovp2BF009606	rogid:ccN33kK/lnKGSE4G3rJ/TvkIEE09606	intact-crc:87F2FB6C76E57548|rigid:gBcFRMEai6Z2T3JQMb6UEqKmI6A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKA8	uniprotkb:Q12929	intact:EBI-9091952|uniprotkb:A4GU14|uniprotkb:Q9UKA7|uniprotkb:E7ENV1|uniprotkb:Q5ECL3|uniprotkb:A4LA69|uniprotkb:Q5TGC6|uniprotkb:E7EWD8|uniprotkb:Q9NUC8|uniprotkb:E3VWE2|uniprotkb:E5L4P0|uniprotkb:E5L4P7|uniprotkb:G1FI66|uniprotkb:G1FLF0|ensembl:ENSP00000363516|ensembl:ENSP00000445401	intact:EBI-375576|uniprotkb:A6NMC3|ensembl:ENSP00000281172|ensembl:ENSP00000441867|ensembl:ENSP00000442388|ensembl:ENSP00000494689|ensembl:ENSP00000494842|ensembl:ENSP00000495722|ensembl:ENSP00000495824|ensembl:ENSP00000495956|ensembl:ENSP00000496406|ensembl:ENSP00000496516|uniprotkb:Q8N6J0|uniprotkb:B4DX66|uniprotkb:A8K6W2|uniprotkb:A8KA66	psi-mi:rcan3_human(display_long)|uniprotkb:DSCR1L2(gene name synonym)|uniprotkb:Down syndrome candidate region 1-like protein 2(gene name synonym)|uniprotkb:Myocyte-enriched calcineurin-interacting protein 3(gene name synonym)|uniprotkb:Regulator of calcineurin 3(gene name synonym)|uniprotkb:RCAN3(gene name)|psi-mi:RCAN3(display_short)	psi-mi:eps8_human(display_long)|uniprotkb:EPS8(gene name)|psi-mi:EPS8(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698145|imex:IM-22632-436	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001238911.1|refseq:NP_001238912.1|refseq:NP_001238914.1|refseq:NP_038469.1|refseq:NP_001238906.1|refseq:NP_001238907.1|refseq:NP_001238908.1|refseq:NP_001238909.1|refseq:NP_001238910.1|refseq:NP_001238913.1|ensembl:ENSG00000117602(gene)|ensembl:ENST00000374395(transcript)|ensembl:ENST00000538532(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031013"(troponin I binding)|interpro:IPR006931(Calcipressin)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034923|interpro:IPR035979|refseq:NM_001251979.1(identity)|entrezgene/locuslink:11123(identity)	ensembl:ENST00000645775(transcript)|ensembl:ENST00000646828(transcript)|ensembl:ENSG00000151491(gene)|ensembl:ENST00000646918(transcript)|ensembl:ENST00000647087(transcript)|ensembl:ENST00000647224(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010458"(exit from mitosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0030426"(growth cone)|go:"GO:0030832"(regulation of actin filament length)|go:"GO:0031267"(small GTPase binding)|ensembl:ENST00000281172(transcript)|ensembl:ENST00000543523(transcript)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|ensembl:ENST00000543612(transcript)|ensembl:ENST00000642278(transcript)|ensembl:ENST00000644374(transcript)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030222|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q12929|rcsb pdb:2E8M|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_004438.3|dip:DIP-32859N|entrezgene/locuslink:2059(identity)|refseq:NM_004447.5(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:GcjmPxKst3ISAOr1WMhJLrYq8JY9606	rogid:ulBgb+4uZ7XrN4bLogRtd9I5AbY9606	intact-crc:1CB70AA5512FB307|rigid:TnvFD/GyTczBmmGNtVCEm52NM1I	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q9UKS6	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-77926|ensembl:ENSP00000298838|ensembl:ENSP00000440945|uniprotkb:A6NH84|uniprotkb:Q9H331|uniprotkb:Q9NWV9	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:pacn3_human(display_long)|uniprotkb:PACSIN3(gene name)|psi-mi:PACSIN3(display_short)|uniprotkb:SH3 domain-containing protein 6511(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698135|imex:IM-22632-435	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008289"(lipid binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR028523|interpro:IPR031160|interpro:IPR036028|mint:Q9UKS6|reactome:R-HSA-8856828|ensembl:ENSG00000165912(gene)|ensembl:ENST00000298838(transcript)|ensembl:ENST00000539589(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|refseq:NP_001171903.1|refseq:NP_001171904.1|refseq:NP_057307.2|refseq:NM_001184974.1(identity)|entrezgene/locuslink:29763(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:kxgltMI3NBu8k0ihTG8Nce63cQE9606	intact-crc:6B0FF4EA19718654|rigid:9KOcVddtQ6uyKp63SCwTb2i/gE8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q9UIH9	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-2796400|ensembl:ENSP00000296233	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:klf15_human(display_long)|uniprotkb:KKLF(gene name synonym)|uniprotkb:Kidney-enriched krueppel-like factor(gene name synonym)|uniprotkb:KLF15(gene name)|psi-mi:KLF15(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698185|imex:IM-22632-440	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_054798.1|refseq:XP_005247457.1|ensembl:ENSG00000163884(gene)|ensembl:ENST00000296233(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016607"(nuclear speck)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9UIH9|rcsb pdb:2ENT|reactome:R-HSA-1368108|entrezgene/locuslink:28999(identity)|refseq:NM_014079.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:vocV1ptKE68rlXylNPMj/4qjo689606	intact-crc:F01309736FF56DA1|rigid:rkXKZx3OdZ1ptA6vhPPeD70OOOs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UIH9	uniprotkb:P46108-2	intact:EBI-2796400|ensembl:ENSP00000296233	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:klf15_human(display_long)|uniprotkb:KKLF(gene name synonym)|uniprotkb:Kidney-enriched krueppel-like factor(gene name synonym)|uniprotkb:KLF15(gene name)|psi-mi:KLF15(display_short)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698175|imex:IM-22632-439	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054798.1|refseq:XP_005247457.1|ensembl:ENSG00000163884(gene)|ensembl:ENST00000296233(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016607"(nuclear speck)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9UIH9|rcsb pdb:2ENT|reactome:R-HSA-1368108|entrezgene/locuslink:28999(identity)|refseq:NM_014079.3(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:vocV1ptKE68rlXylNPMj/4qjo689606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:9E201DD0B4D03C67|rigid:VeupypMm6fbGIwZ/8yGgN16hXrY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:Q9UIH9	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-2796400|ensembl:ENSP00000296233	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:klf15_human(display_long)|uniprotkb:KKLF(gene name synonym)|uniprotkb:Kidney-enriched krueppel-like factor(gene name synonym)|uniprotkb:KLF15(gene name)|psi-mi:KLF15(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698165|imex:IM-22632-438	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_054798.1|refseq:XP_005247457.1|ensembl:ENSG00000163884(gene)|ensembl:ENST00000296233(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016607"(nuclear speck)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9UIH9|rcsb pdb:2ENT|reactome:R-HSA-1368108|entrezgene/locuslink:28999(identity)|refseq:NM_014079.3(identity)	-	crc64:6C00632211C8012D	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:vocV1ptKE68rlXylNPMj/4qjo689606	intact-crc:CDCFAD530E61B658|rigid:F/s7vYzLqEgJVYSpfp2xhKwqcfY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UIH9	uniprotkb:P40763-2	intact:EBI-2796400|ensembl:ENSP00000296233	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:klf15_human(display_long)|uniprotkb:KKLF(gene name synonym)|uniprotkb:Kidney-enriched krueppel-like factor(gene name synonym)|uniprotkb:KLF15(gene name)|psi-mi:KLF15(display_short)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698155|imex:IM-22632-437	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054798.1|refseq:XP_005247457.1|ensembl:ENSG00000163884(gene)|ensembl:ENST00000296233(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016607"(nuclear speck)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9UIH9|rcsb pdb:2ENT|reactome:R-HSA-1368108|entrezgene/locuslink:28999(identity)|refseq:NM_014079.3(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	-	isoform-comment:Contains a phosphotyrosine at position 704.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:vocV1ptKE68rlXylNPMj/4qjo689606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:BE3696B244D891BD|rigid:1PyXL9srDhJ0ka1gXUPfbZhSW5A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHP6	uniprotkb:Q12929	intact:EBI-748350|ensembl:ENSP00000216036	intact:EBI-375576|uniprotkb:A6NMC3|ensembl:ENSP00000281172|ensembl:ENSP00000441867|ensembl:ENSP00000442388|ensembl:ENSP00000494689|ensembl:ENSP00000494842|ensembl:ENSP00000495722|ensembl:ENSP00000495824|ensembl:ENSP00000495956|ensembl:ENSP00000496406|ensembl:ENSP00000496516|uniprotkb:Q8N6J0|uniprotkb:B4DX66|uniprotkb:A8K6W2|uniprotkb:A8KA66	psi-mi:rsp14_human(display_long)|uniprotkb:RSPH14(gene name)|psi-mi:RSPH14(display_short)|uniprotkb:RTDR1(gene name synonym)|uniprotkb:Rhabdoid tumor deletion region protein 1(gene name synonym)	psi-mi:eps8_human(display_long)|uniprotkb:EPS8(gene name)|psi-mi:EPS8(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698205|imex:IM-22632-442	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055248.1|ensembl:ENSG00000100218(gene)|ensembl:ENST00000216036(transcript)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042856|entrezgene/locuslink:27156(identity)|refseq:NM_014433.2(identity)	ensembl:ENST00000645775(transcript)|ensembl:ENST00000646828(transcript)|ensembl:ENSG00000151491(gene)|ensembl:ENST00000646918(transcript)|ensembl:ENST00000647087(transcript)|ensembl:ENST00000647224(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010458"(exit from mitosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0030426"(growth cone)|go:"GO:0030832"(regulation of actin filament length)|go:"GO:0031267"(small GTPase binding)|ensembl:ENST00000281172(transcript)|ensembl:ENST00000543523(transcript)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|ensembl:ENST00000543612(transcript)|ensembl:ENST00000642278(transcript)|ensembl:ENST00000644374(transcript)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030222|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q12929|rcsb pdb:2E8M|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_004438.3|dip:DIP-32859N|entrezgene/locuslink:2059(identity)|refseq:NM_004447.5(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:RQgbM6Qp1my62D1xQm0JeoMB/sU9606	rogid:ulBgb+4uZ7XrN4bLogRtd9I5AbY9606	intact-crc:A89724B5360541E1|rigid:UIW6NF55mFitFAEG2uFtVqqv4qE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UID6	uniprotkb:Q8TB24	intact:EBI-947476|uniprotkb:A9X3Z9|intact:EBI-3451660|uniprotkb:D3DNR3|ensembl:ENSP00000325634|ensembl:ENSP00000417740|ensembl:ENSP00000418766|ensembl:ENSP00000477626	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	psi-mi:zn639_human(display_long)|uniprotkb:ZNF639(gene name)|psi-mi:ZNF639(display_short)|uniprotkb:ZASC1(gene name synonym)|uniprotkb:Zinc finger protein ZASC1(gene name synonym)|uniprotkb:Zinc finger protein ANC_2H01(gene name synonym)	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698195|imex:IM-22632-441	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057415.1|refseq:NP_001290354.1|refseq:NP_001290355.1|refseq:XP_016862039.1|refseq:XP_016862040.1|refseq:XP_016862041.1|refseq:XP_016862042.1|ensembl:ENSG00000121864(gene)|ensembl:ENST00000326361(transcript)|ensembl:ENST00000484866(transcript)|ensembl:ENST00000496856(transcript)|ensembl:ENST00000621687(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|entrezgene/locuslink:51193(identity)|refseq:NM_016331.1(identity)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:hqDnNdTVsE4aB6PRCryUV02vtGg9606	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	intact-crc:1BEBDC7E4854DD41|rigid:S7jtjraktNFqeAkoQaASOoeG0zQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P0L1-2	uniprotkb:P16885	intact:EBI-10698225|ensembl:ENSP00000345404|ensembl:ENSP00000416681|ensembl:ENSP00000486331|ensembl:ENSP00000486642	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	psi-mi:q9p0l1-2(display_long)|uniprotkb:ZKSCAN7(gene name)|psi-mi:ZKSCAN7(display_short)|uniprotkb:ZNF167(gene name synonym)|uniprotkb:ZNF448(gene name synonym)|uniprotkb:ZNF64(gene name synonym)|uniprotkb:Zinc finger protein 167(gene name synonym)|uniprotkb:Zinc finger protein 448(gene name synonym)|uniprotkb:Zinc finger protein 64(gene name synonym)	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698229|imex:IM-22632-444	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-743851(isoform-parent)|ensembl:ENSG00000196345(gene)|ensembl:ENSG00000281894(gene)|ensembl:ENST00000341840(transcript)|ensembl:ENST00000431636(transcript)|ensembl:ENST00000625422(transcript)|ensembl:ENST00000629459(transcript)|uniprotkb:Q9P0L1-2(isoform-parent)|refseq:NM_001288591.1(identity)|entrezgene/locuslink:55888(identity)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:AccqjHSUC4TQy8oMzUYSn14MOWo9606	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	intact-crc:EDDD53C4794BB856|rigid:ZApET/n/sfFihX1t+j3dn5CMok4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P1U0	uniprotkb:Q13387	intact:EBI-355434|ensembl:ENSP00000407364|ensembl:ENSP00000407715|ensembl:ENSP00000410127|ensembl:ENSP00000410530|ensembl:ENSP00000410954|ensembl:ENSP00000412369|ensembl:ENSP00000413265|ensembl:ENSP00000414110|ensembl:ENSP00000414720|ensembl:ENSP00000416599|ensembl:ENSP00000405636|ensembl:ENSP00000331111|ensembl:ENSP00000352333|ensembl:ENSP00000365978|ensembl:ENSP00000365981|ensembl:ENSP00000373108|ensembl:ENSP00000383500|ensembl:ENSP00000383501|ensembl:ENSP00000383503|ensembl:ENSP00000387914|ensembl:ENSP00000391809|ensembl:ENSP00000393236|ensembl:ENSP00000394779|ensembl:ENSP00000395065|ensembl:ENSP00000395397|ensembl:ENSP00000396661|ensembl:ENSP00000396922|ensembl:ENSP00000397636|ensembl:ENSP00000399302|ensembl:ENSP00000399966|ensembl:ENSP00000402198|ensembl:ENSP00000405264	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:rpa12_human(display_long)|uniprotkb:POLR1H(gene name)|psi-mi:POLR1H(display_short)|uniprotkb:DNA-directed RNA polymerase I subunit H(gene name synonym)|uniprotkb:RPA12(gene name synonym)|uniprotkb:ZNRD1(gene name synonym)|uniprotkb:Zinc ribbon domain-containing protein 1(gene name synonym)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698215|imex:IM-22632-443	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055411.1|refseq:NP_740753.1|refseq:NP_001265714.1|refseq:NP_001265715.1|ensembl:ENST00000332435(transcript)|ensembl:ENST00000359374(transcript)|ensembl:ENST00000376782(transcript)|ensembl:ENST00000376785(transcript)|ensembl:ENST00000383613(transcript)|ensembl:ENST00000400659(transcript)|ensembl:ENST00000400660(transcript)|ensembl:ENST00000400662(transcript)|ensembl:ENST00000412396(transcript)|ensembl:ENST00000417275(transcript)|ensembl:ENST00000417738(transcript)|ensembl:ENST00000420100(transcript)|ensembl:ENST00000428913(transcript)|ensembl:ENST00000429558(transcript)|ensembl:ENST00000431032(transcript)|ensembl:ENST00000431416(transcript)|ensembl:ENST00000432227(transcript)|ensembl:ENST00000432545(transcript)|ensembl:ENST00000432904(transcript)|ensembl:ENST00000433264(transcript)|ensembl:ENST00000437373(transcript)|ensembl:ENST00000437507(transcript)|ensembl:ENST00000441251(transcript)|ensembl:ENST00000442585(transcript)|ensembl:ENST00000443142(transcript)|ensembl:ENST00000443494(transcript)|ensembl:ENST00000444027(transcript)|ensembl:ENST00000444794(transcript)|ensembl:ENST00000446493(transcript)|ensembl:ENST00000451875(transcript)|ensembl:ENST00000455948(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006363"(termination of RNA polymerase I transcription)|go:"GO:0006379"(mRNA cleavage)|go:"GO:0008270"(zinc ion binding)|interpro:IPR001222(Zinc finger, TFIIS-type)|interpro:IPR012164(DNA-directed RNA polymerase, subunit C11/M/9)|interpro:IPR019761|interpro:IPR034004|mint:Q9P1U0|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863|ensembl:ENST00000453694(transcript)|ensembl:ENSG00000066379(gene)|ensembl:ENSG00000206502(gene)|ensembl:ENSG00000224859(gene)|ensembl:ENSG00000233795(gene)|ensembl:ENSG00000235176(gene)|ensembl:ENSG00000235443(gene)|ensembl:ENSG00000236808(gene)|ensembl:ENSG00000236949(gene)|entrezgene/locuslink:30834(identity)|refseq:NM_001278785.1(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:zWLcgopYhtpCPeyhS887IK1ZhNw9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:5CE7731A2FB012A6|rigid:x6fZ42rB2KsWVsxJnqwmojyyrSo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NX24	uniprotkb:O75052	intact:EBI-1050064|uniprotkb:Q9P095|uniprotkb:A6NKY8|intact:EBI-5774108|ensembl:ENSP00000274606	intact:EBI-780467|uniprotkb:B7ZLF5|uniprotkb:Q3T551|uniprotkb:O43564|uniprotkb:Q5VU95|ensembl:ENSP00000355133	psi-mi:nhp2_human(display_long)|uniprotkb:Nucleolar protein family A member 2(gene name synonym)|uniprotkb:snoRNP protein NHP2(gene name synonym)|uniprotkb:NHP2(gene name)|psi-mi:NHP2(display_short)|uniprotkb:NOLA2(gene name synonym)|uniprotkb:HSPC286(orf name)	psi-mi:capon_human(display_long)|uniprotkb:C-terminal PDZ ligand of neuronal nitric oxide synthase protein(gene name synonym)|uniprotkb:Nitric oxide synthase 1 adaptor protein(gene name synonym)|uniprotkb:NOS1AP(gene name)|psi-mi:NOS1AP(display_short)|uniprotkb:CAPON(gene name synonym)|uniprotkb:KIAA0464(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698259|imex:IM-22632-447	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060308.1|refseq:NP_001030005.1|ensembl:ENSG00000145912(gene)|ensembl:ENST00000274606(transcript)|go:"GO:0000469"(cleavage involved in rRNA processing)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0072589"(box H/ACA scaRNP complex)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002415(High mobility group-like nuclear protein)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|mint:Q9NX24|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-6790901|refseq:NM_017838.3(identity)|entrezgene/locuslink:55651(identity)	refseq:NP_001119532.2|refseq:NP_001158229.1|refseq:NP_055512.1|ensembl:ENSG00000198929(gene)|ensembl:ENST00000361897(transcript)|go:"GO:0003062"(regulation of heart rate by chemical signal)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903762"(positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:2000170"(positive regulation of peptidyl-cysteine S-nitrosylation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|entrezgene/locuslink:9722(identity)|refseq:NM_014697.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ZZchZSzrw15BqMfddUMcaxZRF0w9606	rogid:bpv0yuTlHR7wYE9SJ4krek2gJXQ9606	intact-crc:2550A486B5DE33E0|rigid:3F2eqyfl5Sii93QDpf92XcjhkWc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q9NZC7	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-4320739|uniprotkb:A8K323|uniprotkb:Q5MYT5|uniprotkb:Q96KM3|uniprotkb:Q96RF2|uniprotkb:Q9BTT8|uniprotkb:Q9NPC9|uniprotkb:Q9NRF4|uniprotkb:Q9NRF5|uniprotkb:Q9NRF6|uniprotkb:Q9NRK1|uniprotkb:Q9NZC5|ensembl:ENSP00000457230	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:wwox_human(display_long)|uniprotkb:WWOX(gene name)|psi-mi:WWOX(display_short)|uniprotkb:FOR(gene name synonym)|uniprotkb:WOX1(gene name synonym)|uniprotkb:Fragile site FRA16D oxidoreductase(gene name synonym)|uniprotkb:SDR41C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 41C member 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698249|imex:IM-22632-446	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	refseq:NP_057457.1|refseq:NP_570607.1|refseq:NP_001278926.1|ensembl:ENST00000566780(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036020|interpro:IPR036291|interpro:IPR042732|mint:Q9NZC7|rcsb pdb:1WMV|reactome:R-HSA-1251985|reactome:R-HSA-8866904|reactome:R-HSA-8866907|ensembl:ENSG00000186153(gene)|entrezgene/locuslink:51741(identity)|refseq:NM_016373.3(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:YMGESSlld4QIPoFrcPX3zhwIy2E9606	intact-crc:FB764462B2178B1E|rigid:r2mFCFTM9/iBF6buOpOaChkeZfs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q9P0L1-2	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-10698225|ensembl:ENSP00000345404|ensembl:ENSP00000416681|ensembl:ENSP00000486331|ensembl:ENSP00000486642	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:q9p0l1-2(display_long)|uniprotkb:ZKSCAN7(gene name)|psi-mi:ZKSCAN7(display_short)|uniprotkb:ZNF167(gene name synonym)|uniprotkb:ZNF448(gene name synonym)|uniprotkb:ZNF64(gene name synonym)|uniprotkb:Zinc finger protein 167(gene name synonym)|uniprotkb:Zinc finger protein 448(gene name synonym)|uniprotkb:Zinc finger protein 64(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698239|imex:IM-22632-445	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	intact:EBI-743851(isoform-parent)|ensembl:ENSG00000196345(gene)|ensembl:ENSG00000281894(gene)|ensembl:ENST00000341840(transcript)|ensembl:ENST00000431636(transcript)|ensembl:ENST00000625422(transcript)|ensembl:ENST00000629459(transcript)|uniprotkb:Q9P0L1-2(isoform-parent)|refseq:NM_001288591.1(identity)|entrezgene/locuslink:55888(identity)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:AccqjHSUC4TQy8oMzUYSn14MOWo9606	intact-crc:3855B24CB5CFF171|rigid:nF1m3n+lJUIsytp+t0guLUKwx8I	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRL3	uniprotkb:P46108	intact:EBI-717245|intact:EBI-1058338|uniprotkb:Q8NE53|uniprotkb:A0A024R0V2|uniprotkb:B4DQH7|uniprotkb:F8VYA6|ensembl:ENSP00000263280	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:strn4_human(display_long)|uniprotkb:Zinedin(gene name synonym)|uniprotkb:STRN4(gene name)|psi-mi:STRN4(display_short)|uniprotkb:ZIN(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698289|imex:IM-22632-450	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034966.1|refseq:NP_037535.2|ensembl:ENSG00000090372(gene)|ensembl:ENST00000263280(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR013258(Striatin, N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9NRL3|refseq:NM_013403.2(identity)|entrezgene/locuslink:29888(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:bgxVT2XfIqKPoGoN0sapQOnwfxw9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:C85FF77CDB159538|rigid:r3uffwBZmq+nAh+LyfgXWqYIqdw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q9NRP7	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-863797|uniprotkb:Q8TC32|uniprotkb:Q9H9N9|uniprotkb:Q9UF35|uniprotkb:Q9ULE2|uniprotkb:B7WPM3|intact:EBI-28979436|ensembl:ENSP00000295709|ensembl:ENSP00000394095	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:stk36_human(display_long)|uniprotkb:Fused homolog(gene name synonym)|uniprotkb:STK36(gene name)|psi-mi:STK36(display_short)|uniprotkb:KIAA1278(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698279|imex:IM-22632-449	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	refseq:NP_001230242.1|refseq:NP_056505.2|refseq:XP_016859293.1|ensembl:ENSP00000295709|ensembl:ENST00000392105|ensembl:ENSP00000375954|ensembl:ENSP00000394095|refseq:XP_005246521.1|ensembl:ENSG00000163482(gene)|ensembl:ENST00000295709(transcript)|ensembl:ENST00000440309(transcript)|go:"GO:0003351"(epithelial cilium movement involved in extracellular fluid movement)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007420"(brain development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NM_015690.4(identity)|entrezgene/locuslink:27148(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:FBVf/FAmEcgW115OM+ER2Gvaqv09606	intact-crc:AB744580867EB184|rigid:xaQjCbqe6xduXw36KG4CUKZ91Ho	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q9NS23-4	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-438710|intact:EBI-8558057|intact:MINT-1919560|intact:EBI-8558167|intact:EBI-8558128|intact:EBI-8558207|intact:EBI-8558030|intact:EBI-8558111|intact:EBI-8557976|ensembl:ENSP00000333327	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:q9ns23-4(display_long)|uniprotkb:RASSF1C(isoform synonym)|uniprotkb:RASSF1(gene name)|psi-mi:RASSF1(display_short)|uniprotkb:RDA32(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698269|imex:IM-22632-448	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	intact:EBI-367363(rsf1_human)|ensembl:ENSG00000068028(gene)|ensembl:ENST00000327761(transcript)|uniprotkb:Q9NS23-4(isoform-parent)|refseq:NM_170713.2(identity)|entrezgene/locuslink:11186(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	isoform-comment:Produced by alternative promoter usage.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:A1efwgOLim3W9ysx9NUap5CEbGI9606	intact-crc:A71752958C34BEDA|rigid:cnWCaChOtOxZz5nvbkCL3dYG/dg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NR55	uniprotkb:P46108-2	intact:EBI-10312707|ensembl:ENSP00000243440	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:batf3_human(display_long)|uniprotkb:BATF3(gene name)|psi-mi:BATF3(display_short)|uniprotkb:21 kDa small nuclear factor isolated from T-cells(gene name synonym)|uniprotkb:Jun dimerization protein p21SNFT(gene name synonym)|uniprotkb:SNFT(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698309|imex:IM-22632-452	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061134.1|ensembl:ENSG00000123685(gene)|ensembl:ENST00000243440(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029818|entrezgene/locuslink:55509(identity)|refseq:NM_018664.2(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:hAyP6YHxONSUFMehlesRDi+E0z49606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:8D52100A0FED3A7E|rigid:eLKNQeY5hgjMVaFuEgaB4ioc8zQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:Q9NR55	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-10312707|ensembl:ENSP00000243440	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:batf3_human(display_long)|uniprotkb:BATF3(gene name)|psi-mi:BATF3(display_short)|uniprotkb:21 kDa small nuclear factor isolated from T-cells(gene name synonym)|uniprotkb:Jun dimerization protein p21SNFT(gene name synonym)|uniprotkb:SNFT(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698299|imex:IM-22632-451	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_061134.1|ensembl:ENSG00000123685(gene)|ensembl:ENST00000243440(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029818|entrezgene/locuslink:55509(identity)|refseq:NM_018664.2(identity)	-	crc64:6C00632211C8012D	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:hAyP6YHxONSUFMehlesRDi+E0z49606	intact-crc:FBEB0423DCD48F37|rigid:VlBlo/BiO8msKiBm7+5ZrJhZ+Ys	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NPJ8-3	uniprotkb:P40763	intact:EBI-10698339|ensembl:ENSP00000218004	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:q9npj8-3(display_long)|uniprotkb:NXT2(gene name)|psi-mi:NXT2(display_short)|uniprotkb:Protein p15-2(gene name synonym)|uniprotkb:BM-025(orf name)|uniprotkb:DC9(orf name)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698343|imex:IM-22632-455	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-752122(isoform-parent)|uniprotkb:Q9NPJ8-3(isoform-parent)|ensembl:ENSG00000101888(gene)|ensembl:ENST00000218004(transcript)|entrezgene/locuslink:55916(identity)|refseq:NM_018698.4(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SzskGc0tV05vHKJ1qmdmTsfPabA9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:96373D1D103D7C91|rigid:1+0pFqGqPl4jmWdUInncgShkMEo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NQZ8	uniprotkb:Q8TB24	intact:EBI-7138235|ensembl:ENSP00000328245|uniprotkb:Q15919|intact:MINT-8247445|uniprotkb:Q9UC09|uniprotkb:Q9UQD3	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	psi-mi:znf71_human(display_long)|uniprotkb:ZNF71(gene name)|psi-mi:ZNF71(display_short)|uniprotkb:EZFIT(gene name synonym)|uniprotkb:Zinc finger protein 71(gene name synonym)	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698329|imex:IM-22632-454	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000197951(gene)|ensembl:ENST00000328070(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9NQZ8|reactome:R-HSA-212436|refseq:NP_067039.1|refseq:XP_016882569.1|entrezgene/locuslink:58491(identity)|refseq:NM_021216.4(identity)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	-	comment:mint|comment:homomint	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:fKzvT4VMXtBi2PDzL9iATU2wjGQ9606	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	intact-crc:4308D395B9CC6D5F|rigid:8sqjbmMqaIgpIrYL4zsXqPpa2Kg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NR55	uniprotkb:P46108	intact:EBI-10312707|ensembl:ENSP00000243440	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:batf3_human(display_long)|uniprotkb:BATF3(gene name)|psi-mi:BATF3(display_short)|uniprotkb:21 kDa small nuclear factor isolated from T-cells(gene name synonym)|uniprotkb:Jun dimerization protein p21SNFT(gene name synonym)|uniprotkb:SNFT(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698319|imex:IM-22632-453	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061134.1|ensembl:ENSG00000123685(gene)|ensembl:ENST00000243440(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029818|entrezgene/locuslink:55509(identity)|refseq:NM_018664.2(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:hAyP6YHxONSUFMehlesRDi+E0z49606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:5131CF083CC3EB86|rigid:fGyPzVpgl3RELEuFv+dG8WFvUuY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TB24	uniprotkb:Q9H765	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	intact:EBI-3942509|uniprotkb:Q547Q2|uniprotkb:A8K1P2|ensembl:ENSP00000320893|ensembl:ENSP00000445622	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:asb8_human(display_long)|uniprotkb:ASB8(gene name)|psi-mi:ASB8(display_short)|uniprotkb:PP14212(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698363|imex:IM-22632-457	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	ensembl:ENSG00000177981(gene)|ensembl:ENST00000317697(transcript)|ensembl:ENST00000536549(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036036|interpro:IPR036770|interpro:IPR037332|mint:Q9H765|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_077000.1|refseq:NP_001306225.1|refseq:NP_001306226.1|refseq:NP_001306227.1|refseq:NP_001306228.1|refseq:NP_001306229.1|refseq:NP_001306230.1|entrezgene/locuslink:140461(identity)|refseq:NM_024095.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	rogid:TLjOfkyUnX91j0Lh2kZvf2uBMGI9606	intact-crc:6BEC09B9C3BC55EF|rigid:ORdfaRCehAUNt3JXpyhyVvFatt4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H7T9	uniprotkb:Q92569	intact:EBI-10693257|uniprotkb:C9EI59|uniprotkb:Q53F70|ensembl:ENSP00000363416	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:aunip_human(display_long)|uniprotkb:AUNIP(gene name)|psi-mi:AUNIP(display_short)|uniprotkb:C1orf135(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698353|imex:IM-22632-456	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001274419.1|refseq:NP_076942.1|ensembl:ENSG00000127423(gene)|ensembl:ENST00000374298(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000922"(spindle pole)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0090734"(site of DNA damage)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR029286|entrezgene/locuslink:79000(identity)|refseq:NM_024037.2(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:z7isXKkndjeP4zxnq0kVAW+ZmRo9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:28DCA2D792B31B1A|rigid:wd+PdFUwZfglSUF1SqtJg9SG7RU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H6S3	uniprotkb:Q8TB24	intact:EBI-3940939|uniprotkb:Q53GM8|uniprotkb:Q9H6K9|uniprotkb:B3KSX1|uniprotkb:Q96K06|uniprotkb:Q8WYW7|ensembl:ENSP00000320828|ensembl:ENSP00000435585|ensembl:ENSP00000436035|uniprotkb:B7ZKL3	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	psi-mi:es8l2_human(display_long)|uniprotkb:EPS8L2(gene name)|psi-mi:EPS8L2(display_short)|uniprotkb:EPS8R2(gene name synonym)|uniprotkb:Epidermal growth factor receptor pathway substrate 8-related protein 2(gene name synonym)|uniprotkb:PP13181(orf name)	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698393|imex:IM-22632-460	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177106(gene)|ensembl:ENST00000318562(transcript)|ensembl:ENST00000530636(transcript)|ensembl:ENST00000533256(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0031982"(vesicle)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0045296"(cadherin binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q9H6S3|rcsb pdb:1WWU|rcsb pdb:1WXB|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_073609.2|refseq:XP_016873619.1|refseq:XP_016873620.1|refseq:XP_016873621.1|refseq:NM_022772.3(identity)|entrezgene/locuslink:64787(identity)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:fm46f0tF2y2QGPLD7dk77JUHMXA9606	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	intact-crc:CB0E41DFC05FA9B7|rigid:lA/2AqkMkFRS7DH3HIkYuZVnhyo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H6Z4-3	uniprotkb:P52757	intact:EBI-10697282|ensembl:ENSP00000034275	intact:EBI-714925|uniprotkb:Q2M203|uniprotkb:Q75MM2|uniprotkb:A4D1A2|uniprotkb:F8QPL9|ensembl:ENSP00000222792|uniprotkb:E9PGE0|uniprotkb:B3VCF1|uniprotkb:B3VCF2|uniprotkb:B3VCF3|uniprotkb:C9J7B0|uniprotkb:B3VCF7|uniprotkb:B3VCG1	psi-mi:q9h6z4-3(display_long)|uniprotkb:RANBP3(gene name)|psi-mi:RANBP3(display_short)|uniprotkb:Ranbp3-b(isoform synonym)	psi-mi:chio_human(display_long)|uniprotkb:Beta-chimerin(gene name synonym)|uniprotkb:Rho GTPase-activating protein 3(gene name synonym)|uniprotkb:CHN2(gene name)|psi-mi:CHN2(display_short)|uniprotkb:ARHGAP3(gene name synonym)|uniprotkb:BCH(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698383|imex:IM-22632-459	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000031823(gene)|ensembl:ENST00000034275(transcript)|intact:EBI-992681(isoform-parent)|refseq:NM_007320.2(identity)|entrezgene/locuslink:8498(identity)	refseq:NP_001279998.1|refseq:NP_001279999.1|refseq:NP_001280000.1|refseq:NP_001280002.1|refseq:NP_001280004.1|refseq:NP_001280005.1|refseq:NP_001280006.1|refseq:NP_001280007.1|refseq:NP_001280008.1|refseq:NP_001280009.1|refseq:NP_001035025.1|refseq:NP_004058.1|interpro:IPR036860|interpro:IPR037860|mint:P52757|rcsb pdb:1XA6|reactome:R-HSA-9013149|interpro:IPR035840|ensembl:ENSG00000106069(gene)|ensembl:ENST00000222792(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR017356(N-chimaerin)|interpro:IPR020454|entrezgene/locuslink:1124(identity)|refseq:NM_004067.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:6+p38qWekYDJW/6zBD1EJNdVlBM9606	rogid:drcrV4yAbGTuSAJYNjjopBQxFDM9606	intact-crc:F1A595EE71265400|rigid:aGpl0IpPeYpg6pbYyZhc4WJrvZs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75791	uniprotkb:Q9H706	intact:EBI-740418|uniprotkb:B7Z8I3|uniprotkb:O43726|uniprotkb:Q9NRB7|ensembl:ENSP00000339186|ensembl:ENSP00000385607	intact:EBI-3440103|uniprotkb:Q0VAG3|uniprotkb:Q9BSF5|uniprotkb:Q8ND03|uniprotkb:Q0VAG4|intact:EBI-28975682|ensembl:ENSP00000269209	psi-mi:grap2_human(display_long)|uniprotkb:Protein GADS(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:Grf40 adapter protein(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:GRBX(gene name synonym)|uniprotkb:P38(gene name synonym)|uniprotkb:Hematopoietic cell-associated adapter protein GrpL(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:SH3-SH2-SH3 adapter Mona(gene name synonym)|uniprotkb:GRAP2(gene name)|psi-mi:GRAP2(display_short)|uniprotkb:GADS(gene name synonym)|uniprotkb:GRB2L(gene name synonym)|uniprotkb:GRID(gene name synonym)	psi-mi:gare1_human(display_long)|uniprotkb:GAREM1(gene name)|psi-mi:GAREM1(display_short)|uniprotkb:C18orf11(gene name synonym)|uniprotkb:FAM59A(gene name synonym)|uniprotkb:GAREM(gene name synonym)|uniprotkb:GRB2-associated and regulator of MAPK1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698373|imex:IM-22632-458	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278753.1|refseq:NP_001278754.1|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O75791|rcsb pdb:5GJH|reactome:R-HSA-1433557|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-389356|reactome:R-HSA-9607240|interpro:IPR000980(SH2 motif)|refseq:NP_004801.1|ensembl:ENSG00000100351(gene)|ensembl:ENST00000344138(transcript)|ensembl:ENST00000407075(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007267"(cell-cell signaling)|refseq:NP_001278757.1|dip:DIP-38435N|entrezgene/locuslink:9402(identity)|refseq:NM_004810.3(identity)	ensembl:ENSP00000269209|ensembl:ENST00000399218|ensembl:ENSP00000382165|refseq:NP_001229338.1|refseq:NP_073588.1|ensembl:ENSG00000141441(gene)|ensembl:ENST00000269209(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR025946|rcsb pdb:2DKZ|entrezgene/locuslink:64762(identity)|refseq:NM_001242409.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:eDZoV+vaCfLAcmbcN5LlJMDiuZ09606	rogid:QEmdhomnnbwOJjOYfPZptJdHqbA9606	intact-crc:81FCBB0EF7D1CA32|rigid:s8YkHIR3WDbO4/hgYV9A3GNbHrU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BZF3-6	uniprotkb:Q96IW2	intact:EBI-10698423|ensembl:ENSP00000349591	intact:EBI-4402781|uniprotkb:Q96NC2|ensembl:ENSP00000446058	psi-mi:q9bzf3-6(display_long)|uniprotkb:OSBPL6(gene name)|psi-mi:OSBPL6(display_short)|uniprotkb:ORP6(gene name synonym)	psi-mi:shd_human(display_long)|uniprotkb:SHD(gene name)|psi-mi:SHD(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698427|imex:IM-22632-463	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2372709(isoform-parent)|uniprotkb:Q9BZF3-6(isoform-parent)|ensembl:ENSG00000079156(gene)|ensembl:ENST00000357080(transcript)|refseq:XM_005246268.1(identity)|entrezgene/locuslink:114880(identity)	refseq:NP_064594.3|ensembl:ENSG00000105251(gene)|go:"GO:0001784"(phosphotyrosine residue binding)|interpro:IPR000980(SH2 motif)|interpro:IPR035039|interpro:IPR035046|interpro:IPR036860|ensembl:ENST00000543264(transcript)|entrezgene/locuslink:56961(identity)|refseq:NM_020209.3(identity)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:bXmjstIbUoMOUgKO4aPo8A0yZXI9606	rogid:c2PsXxVdBB1dLj+Lu40XdgOb2yY9606	intact-crc:273D7B0D0571F9A2|rigid:zi2Pc/OpvdXbgAGkuseSKGTuzc0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9C004	uniprotkb:Q8TB24	intact:EBI-354861|uniprotkb:Q6QIX2|uniprotkb:A4FVB3|uniprotkb:Q9C003|uniprotkb:A4FVB2|ensembl:ENSP00000399468	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	psi-mi:spy4_human(display_long)|uniprotkb:SPRY4(gene name)|psi-mi:SPRY4(display_short)	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698413|imex:IM-22632-462	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001120968.1|refseq:NP_112226.2|refseq:NP_001280218.1|refseq:NP_001280219.1|refseq:XP_011535987.1|refseq:XP_016865399.1|ensembl:ENSG00000187678(gene)|ensembl:ENST00000434127(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048513"(animal organ development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007875(Sprouty)|interpro:IPR030790|mint:Q9C004|rcsb pdb:3BUN|entrezgene/locuslink:81848(identity)|refseq:NM_001127496.1(identity)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:NjkIqofg1Fl1PXj8FXVFz10JOUg9606	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	intact-crc:012C4DCCB169B9F7|rigid:rlYv/ViXn4xlkwNPv9k1hO0n+T4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H1D9	uniprotkb:Q8TB24	intact:EBI-710067|uniprotkb:O15319|uniprotkb:A8K4C7|ensembl:ENSP00000366828	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	psi-mi:rpc6_human(display_long)|uniprotkb:DNA-directed RNA polymerase III subunit F(gene name synonym)|uniprotkb:RNA polymerase III 39 kDa subunit(gene name synonym)|uniprotkb:POLR3F(gene name)|psi-mi:POLR3F(display_short)	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698403|imex:IM-22632-461	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269455.1|refseq:NP_006457.2|dip:DIP-34646N|ensembl:ENSG00000132664(gene)|ensembl:ENST00000377603(transcript)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|interpro:IPR007832(RNA polymerase Rpc34)|interpro:IPR016049(RNA polymerase Rpc34-like)|interpro:IPR036388|interpro:IPR036390|mint:Q9H1D9|rcsb pdb:2DK5|rcsb pdb:2YU3|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|entrezgene/locuslink:10621(identity)|refseq:NM_006466.3(identity)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uqwUHkGa31Zl21767NrQK6nKbF09606	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	intact-crc:ED311FE00100EA21|rigid:NXOU1geVEZFE14j8PR76Nc3MTbk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:Q9BXM7	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698457|imex:IM-22632-466	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N|entrezgene/locuslink:65018(identity)|refseq:NM_032409.2(identity)	-	crc64:6C00632211C8012D	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	intact-crc:C699B125062230D6|rigid:ExLUNG+taHmSV1ZfcqxHyocdTiM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763-2	uniprotkb:Q9BXM7	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698447|imex:IM-22632-465	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N|entrezgene/locuslink:65018(identity)|refseq:NM_032409.2(identity)	-	isoform-comment:Contains a phosphotyrosine at position 704.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	intact-crc:8FE01E1E234FB13A|rigid:hCZnUvFzXYrsSbCAT4PDU6kqCXg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BYZ2	uniprotkb:Q8NEU8	intact:EBI-1108377|uniprotkb:Q6DUY4|uniprotkb:Q96LI2|ensembl:ENSP00000302393	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	psi-mi:ldh6b_human(display_long)|uniprotkb:LDHAL6B(gene name)|psi-mi:LDHAL6B(display_short)|uniprotkb:LDHAL6(gene name synonym)|uniprotkb:LDHL(gene name synonym)	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698437|imex:IM-22632-464	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000171989(gene)|ensembl:ENST00000307144(transcript)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:Q9BYZ2|reactome:R-HSA-70268|refseq:NP_149972.1|entrezgene/locuslink:92483(identity)|refseq:NM_033195.2(identity)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:VktHnjwxkeayt64SWFxLAq4YlLQ9606	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	intact-crc:317DA6222C50ECBD|rigid:lI0U2359c7xE9kOldOhnC42TYrM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P104-2	uniprotkb:Q9BXL8	intact:EBI-10692909|ensembl:ENSP00000379270	intact:EBI-1773949|uniprotkb:Q8TB18|uniprotkb:Q9NWK7|ensembl:ENSP00000337226|ensembl:ENSP00000376369	psi-mi:q9p104-2(display_long)|uniprotkb:DOK5(gene name)|psi-mi:DOK5(display_short)|uniprotkb:C20orf180(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 5(gene name synonym)|uniprotkb:Insulin receptor substrate 6(gene name synonym)	psi-mi:cdca4_human(display_long)|uniprotkb:CDCA4(gene name)|psi-mi:CDCA4(display_short)|uniprotkb:HEPP(gene name synonym)|uniprotkb:Hematopoietic progenitor protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698477|imex:IM-22632-468	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101134(gene)|ensembl:ENST00000395939(transcript)|intact:EBI-739600(isoform-parent)|uniprotkb:Q9P104-2(isoform-parent)|refseq:NM_177959.2(identity)|entrezgene/locuslink:55816(identity)	refseq:NP_060425.2|refseq:NP_663747.1|ensembl:ENSG00000170779(gene)|ensembl:ENST00000336219(transcript)|ensembl:ENST00000392590(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0048096"|interpro:IPR009263(SERTA)|mint:Q9BXL8|entrezgene/locuslink:55038(identity)|refseq:NM_145701.2(identity)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8p18JpE/uszPiQyb4FtcEu5QiOc9606	rogid:sxwZ0Yw0uG+MjnhKtVv+8PHvPCo9606	intact-crc:3F994380F840FA5A|rigid:NqvJMFnlKFWM6Q8SF1tKHFLmQOQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEU8	uniprotkb:Q9BXM7	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698467|imex:IM-22632-467	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N|entrezgene/locuslink:65018(identity)|refseq:NM_032409.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	intact-crc:86FE6E890E6BF1E1|rigid:sKn8FNHaFm4OJ+jwbz/nESZzOsg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BRX9	uniprotkb:P46108-2	intact:EBI-7705033|intact:EBI-28975578|ensembl:ENSP00000402653|intact:MINT-4776445|uniprotkb:B2RAF1|uniprotkb:Q53FT6	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:wdr83_human(display_long)|uniprotkb:WDR83(gene name)|psi-mi:WDR83(display_short)|uniprotkb:MORG1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase organizer 1(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698507|imex:IM-22632-471	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000402653|ensembl:ENSG00000123154(gene)|ensembl:ENST00000418543(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0010008"(endosome membrane)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9BRX9|reactome:R-HSA-5674135|refseq:NP_115708.1|refseq:NP_001093207.1|refseq:NM_032332.3(identity)|entrezgene/locuslink:84292(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	comment:mint|comment:homomint|function:"Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing"	isoform-comment:Contains a phosphoserine at position 194.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:p+W60A6W8VtTfMMqMNjACQY6Wk09606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:A67C848C067932A5|rigid:xYczIMMVg6ArlnsI71294BkqDAo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:Q9BS34	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-745276|intact:EBI-28980552|ensembl:ENSP00000355459	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:zn670_human(display_long)|uniprotkb:ZNF670(gene name)|psi-mi:ZNF670(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698497|imex:IM-22632-470	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	refseq:NP_149990.1|ensembl:ENSP00000355459|ensembl:ENSG00000277462(gene)|ensembl:ENST00000366503(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9BS34|reactome:R-HSA-212436|entrezgene/locuslink:93474(identity)|refseq:NM_033213.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:rLN4zdWhS14BhRLxojEevuc2Knc9606	intact-crc:ACC2A9CB2EE0DDF7|rigid:Kkx8kWzrs4ebU9Bt+hSa5hWzZUc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:Q9BWF3	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-2856454|uniprotkb:B3KUN0|uniprotkb:Q8WU85|uniprotkb:Q6P1P2|uniprotkb:O02916|uniprotkb:Q4VC48|uniprotkb:B4E1U0|uniprotkb:E7EQS3|ensembl:ENSP00000309166|ensembl:ENSP00000386561|ensembl:ENSP00000386894	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:rbm4_human(display_long)|uniprotkb:RBM4(gene name)|psi-mi:RBM4(display_short)|uniprotkb:RBM4A(gene name synonym)|uniprotkb:Lark homolog(gene name synonym)|uniprotkb:RNA-binding motif protein 4(gene name synonym)|uniprotkb:RNA-binding motif protein 4a(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698487|imex:IM-22632-469	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	refseq:NP_001185772.1|refseq:NP_002887.2|refseq:NP_001185773.1|dip:DIP-44199N|ensembl:ENSG00000173933(gene)|ensembl:ENST00000310092(transcript)|ensembl:ENST00000408993(transcript)|ensembl:ENST00000409406(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0002190"(cap-independent translational initiation)|go:"GO:0002192"(IRES-dependent translational initiation of linear mRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030332"(cyclin binding)|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:0097158"(pre-mRNA intronic pyrimidine-rich binding)|go:"GO:0097167"(circadian regulation of translation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR034897|interpro:IPR034898|interpro:IPR035979|mint:Q9BWF3|rcsb pdb:2DNQ|reactome:R-HSA-400253|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NM_002896.3(identity)|entrezgene/locuslink:5936(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:hbW6dv/AEWQz3mWvA2/9n8h/bbA9606	intact-crc:035C9DB67AA7348E|rigid:4K6CDmyaLOu37Xa3D1oweAZezdA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BRX9	uniprotkb:P46108	intact:EBI-7705033|intact:EBI-28975578|ensembl:ENSP00000402653|intact:MINT-4776445|uniprotkb:B2RAF1|uniprotkb:Q53FT6	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:wdr83_human(display_long)|uniprotkb:WDR83(gene name)|psi-mi:WDR83(display_short)|uniprotkb:MORG1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase organizer 1(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698517|imex:IM-22632-472	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000402653|ensembl:ENSG00000123154(gene)|ensembl:ENST00000418543(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0010008"(endosome membrane)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9BRX9|reactome:R-HSA-5674135|refseq:NP_115708.1|refseq:NP_001093207.1|refseq:NM_032332.3(identity)|entrezgene/locuslink:84292(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	comment:mint|comment:homomint|function:"Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing"	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:p+W60A6W8VtTfMMqMNjACQY6Wk09606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:9F0AC5BE067ABAE5|rigid:rxWkBoWRbkEFwlfzh5AkwtlJ8k4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BQE3	uniprotkb:P46108	intact:EBI-1103245|ensembl:ENSP00000301072	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:tba1c_human(display_long)|uniprotkb:TUBA1C(gene name)|psi-mi:TUBA1C(display_short)|uniprotkb:TUBA6(gene name synonym)|uniprotkb:Tubulin alpha-6 chain(gene name synonym)|uniprotkb:Alpha-tubulin 6(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698527|imex:IM-22632-473	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|ensembl:ENSG00000167553(gene)|ensembl:ENST00000301072(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031982"(vesicle)|go:"GO:0051301"(cell division)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9BQE3|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_116093.1|refseq:NM_032704.3(identity)|entrezgene/locuslink:84790(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:53r1CNUJNgCreVCw4riUsTPh+yw9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:F95A7E42239F2FF2|rigid:xwche/CDIsJGdk/ApHT3cC7MzMc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96SW2-2	uniprotkb:Q92569	intact:EBI-10693561|ensembl:ENSP00000412499	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698547|imex:IM-22632-475	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent)|entrezgene/locuslink:51185(identity)|refseq:NM_001173482.1(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:11D6B21E5609946A|rigid:rLo6M59F0DVgedsYrU6VrRrokR4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q96S55-2	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-2523861|ensembl:ENSP00000370148	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:q96s55-2(display_long)|uniprotkb:WRNIP1(gene name)|psi-mi:WRNIP1(display_short)|uniprotkb:WHIP(gene name synonym)|uniprotkb:Werner helicase-interacting protein 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698557|imex:IM-22632-476	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	ensembl:ENSG00000124535(gene)|ensembl:ENST00000380771(transcript)|intact:EBI-2513471(isoform-parent)|refseq:NM_130395.2(identity)|entrezgene/locuslink:56897(identity)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:aL/kZ6OOB8VE+7+GUsxEcoYc9FM9606	intact-crc:6F9807471CAA3C38|rigid:Sh+0WAs5IrlbrVcqCSPPlCioDu4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96SW2-2	uniprotkb:Q8NEU8	intact:EBI-10693561|ensembl:ENSP00000412499	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name)	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698537|imex:IM-22632-474	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent)|entrezgene/locuslink:51185(identity)|refseq:NM_001173482.1(identity)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	intact-crc:6AD9CC71F9EE222F|rigid:HsoEDxaRjzpIsVcO33yZsBMbl14	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96R05	uniprotkb:Q8NEU8	intact:EBI-2856326|uniprotkb:B2R517|uniprotkb:Q5SWJ4|ensembl:ENSP00000294435	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	psi-mi:ret7_human(display_long)|uniprotkb:RBP7(gene name)|psi-mi:RBP7(display_short)|uniprotkb:Cellular retinoic acid-binding protein 4(gene name synonym)|uniprotkb:Cellular retinoic acid-binding protein IV(gene name synonym)	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698577|imex:IM-22632-478	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443192.1|interpro:IPR031259|rcsb pdb:1LPJ|rcsb pdb:6AT8|rcsb pdb:6E6K|ensembl:ENSG00000162444(gene)|ensembl:ENST00000294435(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016918"(retinal binding)|go:"GO:0019841"(retinol binding)|interpro:IPR000463(Cytosolic fatty-acid binding)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|entrezgene/locuslink:116362(identity)|refseq:NM_052960.2(identity)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	-	-	-	figure legend:Suppl. table S4, suppl. fig. S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:75axWxV5mnxExd1avjdlOUK4o2E9606	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	intact-crc:3E7647A9EC51C969|rigid:8giXYR3zO6kG9cw23rfupUTHQaA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52757	uniprotkb:Q96S44	intact:EBI-714925|uniprotkb:Q2M203|uniprotkb:Q75MM2|uniprotkb:A4D1A2|uniprotkb:F8QPL9|ensembl:ENSP00000222792|uniprotkb:E9PGE0|uniprotkb:B3VCF1|uniprotkb:B3VCF2|uniprotkb:B3VCF3|uniprotkb:C9J7B0|uniprotkb:B3VCF7|uniprotkb:B3VCG1	intact:EBI-739588|uniprotkb:Q3T977|uniprotkb:Q5JZ01|uniprotkb:Q6NZ60|uniprotkb:Q96FM7|uniprotkb:Q9NQE6|uniprotkb:B3KU44|ensembl:ENSP00000361186	psi-mi:chio_human(display_long)|uniprotkb:Beta-chimerin(gene name synonym)|uniprotkb:Rho GTPase-activating protein 3(gene name synonym)|uniprotkb:CHN2(gene name)|psi-mi:CHN2(display_short)|uniprotkb:ARHGAP3(gene name synonym)|uniprotkb:BCH(gene name synonym)	psi-mi:prpk_human(display_long)|uniprotkb:TP53-regulating kinase(gene name synonym)|uniprotkb:TP53RK(gene name)|psi-mi:TP53RK(display_short)|uniprotkb:C20orf64(gene name synonym)|uniprotkb:PRPK(gene name synonym)|uniprotkb:p53-related protein kinase(gene name synonym)|uniprotkb:Nori-2(gene name synonym)|uniprotkb:Atypical serine/threonine protein kinase TP53RK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698567|imex:IM-22632-477	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001279998.1|refseq:NP_001279999.1|refseq:NP_001280000.1|refseq:NP_001280002.1|refseq:NP_001280004.1|refseq:NP_001280005.1|refseq:NP_001280006.1|refseq:NP_001280007.1|refseq:NP_001280008.1|refseq:NP_001280009.1|refseq:NP_001035025.1|refseq:NP_004058.1|interpro:IPR036860|interpro:IPR037860|mint:P52757|rcsb pdb:1XA6|reactome:R-HSA-9013149|interpro:IPR035840|ensembl:ENSG00000106069(gene)|ensembl:ENST00000222792(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR017356(N-chimaerin)|interpro:IPR020454|entrezgene/locuslink:1124(identity)|refseq:NM_004067.3(identity)	refseq:NP_291028.3|ensembl:ENSG00000172315(gene)|ensembl:ENST00000372114(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008033"(tRNA processing)|go:"GO:0016787"(hydrolase activity)|go:"GO:0070525"(tRNA threonylcarbamoyladenosine metabolic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022495|rcsb pdb:6WQX|reactome:R-HSA-6782315|reactome:R-HSA-6804756|refseq:NM_033550.3(identity)|entrezgene/locuslink:112858(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:drcrV4yAbGTuSAJYNjjopBQxFDM9606	rogid:sgh5tCNgPpL4E4SmEQhLz6qci109606	intact-crc:0723A66F319AC5AA|rigid:2FlhoiuQW8EN97rxz7TEQ1nXKJA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UN19	uniprotkb:Q96R05	intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602	intact:EBI-2856326|uniprotkb:B2R517|uniprotkb:Q5SWJ4|ensembl:ENSP00000294435	psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name)	psi-mi:ret7_human(display_long)|uniprotkb:RBP7(gene name)|psi-mi:RBP7(display_short)|uniprotkb:Cellular retinoic acid-binding protein 4(gene name synonym)|uniprotkb:Cellular retinoic acid-binding protein IV(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698597|imex:IM-22632-480	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695|entrezgene/locuslink:27071(identity)|refseq:NM_014395.2(identity)	refseq:NP_443192.1|interpro:IPR031259|rcsb pdb:1LPJ|rcsb pdb:6AT8|rcsb pdb:6E6K|ensembl:ENSG00000162444(gene)|ensembl:ENST00000294435(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016918"(retinal binding)|go:"GO:0019841"(retinol binding)|interpro:IPR000463(Cytosolic fatty-acid binding)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|entrezgene/locuslink:116362(identity)|refseq:NM_052960.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:YYI49xKbndaB1MfL/QEovp2BF009606	rogid:75axWxV5mnxExd1avjdlOUK4o2E9606	intact-crc:17D9A5945E6748C7|rigid:QRK/RW8u7B2LpXluG+WgiXpm1kk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TB24	uniprotkb:Q96PN8	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	intact:EBI-3918381|uniprotkb:Q5TEE5|ensembl:ENSP00000362634	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:tssk3_human(display_long)|uniprotkb:TSSK3(gene name)|psi-mi:TSSK3(display_short)|uniprotkb:SPOGA3(gene name synonym)|uniprotkb:STK22C(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 22C(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698607|imex:IM-22632-481	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042709|refseq:NP_443073.1|ensembl:ENSG00000162526(gene)|ensembl:ENST00000373534(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|refseq:NM_052841.3(identity)|entrezgene/locuslink:81629(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	rogid:Vf2gTMGnxU1TOMSrv+xkB35fWRo9606	intact-crc:64EB549E242E029F|rigid:MhNjlVwsp4pfBZLgoRU1tPvukrw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TEW6	uniprotkb:Q96R05	intact:EBI-6918542|ensembl:ENSP00000344277|ensembl:ENSP00000455128|uniprotkb:O75209|uniprotkb:Q9BTP2|uniprotkb:Q9NVV3	intact:EBI-2856326|uniprotkb:B2R517|uniprotkb:Q5SWJ4|ensembl:ENSP00000294435	psi-mi:dok4_human(display_long)|uniprotkb:DOK4(gene name)|psi-mi:DOK4(display_short)|uniprotkb:Downstream of tyrosine kinase 4(gene name synonym)|uniprotkb:Insulin receptor substrate 5(gene name synonym)	psi-mi:ret7_human(display_long)|uniprotkb:RBP7(gene name)|psi-mi:RBP7(display_short)|uniprotkb:Cellular retinoic acid-binding protein 4(gene name synonym)|uniprotkb:Cellular retinoic acid-binding protein IV(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698587|imex:IM-22632-479	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000125170(gene)|ensembl:ENST00000340099(transcript)|ensembl:ENST00000569548(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0043410"(positive regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_060580.2|refseq:XP_005256100.1|entrezgene/locuslink:55715(identity)|refseq:NM_018110.3(identity)	refseq:NP_443192.1|interpro:IPR031259|rcsb pdb:1LPJ|rcsb pdb:6AT8|rcsb pdb:6E6K|ensembl:ENSG00000162444(gene)|ensembl:ENST00000294435(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016918"(retinal binding)|go:"GO:0019841"(retinol binding)|interpro:IPR000463(Cytosolic fatty-acid binding)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|entrezgene/locuslink:116362(identity)|refseq:NM_052960.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Xc4aPsHtdQKj02Q5cqqgw29pSS09606	rogid:75axWxV5mnxExd1avjdlOUK4o2E9606	intact-crc:EB5652E05B173B26|rigid:mL+4yWUkcut57cEUDGGoL3d36FI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96LK0	uniprotkb:Q92569	intact:EBI-741885|uniprotkb:Q96I48|uniprotkb:B2RA74|ensembl:ENSP00000387209	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:cep19_human(display_long)|uniprotkb:CEP19(gene name)|psi-mi:CEP19(display_short)|uniprotkb:HSD5(orf name)|uniprotkb:C3orf34(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698631|imex:IM-22632-483	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116287.2|ensembl:ENSG00000174007(gene)|ensembl:ENST00000409690(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005929"(cilium)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:0097712"(vesicle targeting, trans-Golgi to periciliary membrane compartment)|interpro:IPR029412|refseq:XP_005269427.1|refseq:XP_011511548.1|refseq:NM_032898.4(identity)|entrezgene/locuslink:84984(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:geHo/p9Et8jWY8BXC41truaYSV49606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:5200A17C7B5605BB|rigid:OkTw2pluIhivKZh/n1/5+UQvePU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:Q96NL6-4	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-10698617|ensembl:ENSP00000420861	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:q96nl6-4(display_long)|uniprotkb:SCLT1(gene name)|psi-mi:SCLT1(display_short)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Sodium channel-associated protein 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698621|imex:IM-22632-482	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	ensembl:ENSG00000151466(gene)|ensembl:ENST00000511426(transcript)|intact:EBI-2514016(isoform-parent)|entrezgene/locuslink:132320(identity)|refseq:NM_001300897.1(identity)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:VRYhVYCHmGeYkxmq5JLJt12CpBY9606	intact-crc:7DCF149A768543F9|rigid:9W7SAqSZ5l9dU4Slfdu6ydVGO00	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763-2	uniprotkb:Q96KP4	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	intact:EBI-1190734|uniprotkb:Q9BQ94|uniprotkb:Q9NVB4|uniprotkb:Q8WY59|uniprotkb:B3KUG4|uniprotkb:V9HWE5|ensembl:ENSP00000325548|ensembl:ENSP00000462311	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:cndp2_human(display_long)|uniprotkb:CNDP dipeptidase 2(gene name synonym)|uniprotkb:Glutamate carboxypeptidase-like protein 1(gene name synonym)|uniprotkb:Peptidase A(gene name synonym)|uniprotkb:HEL-S-13(gene name synonym)|uniprotkb:CNDP2(gene name)|psi-mi:CNDP2(display_short)|uniprotkb:CN2(gene name synonym)|uniprotkb:CPGL(gene name synonym)|uniprotkb:PEPA(gene name synonym)|uniprotkb:Threonyl dipeptidase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698641|imex:IM-22632-484	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_001161971.1|refseq:NP_060705.2|refseq:XP_005266785.1|refseq:XP_006722566.1|refseq:XP_011524373.1|refseq:XP_011524374.1|ensembl:ENSG00000133313(gene)|ensembl:ENST00000324262(transcript)|ensembl:ENST00000579847(transcript)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0016805"(dipeptidase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070573"(metallodipeptidase activity)|go:"GO:0103046"(alanylglutamate dipeptidase activity)|interpro:IPR001261(ArgE/DapE/ACY1/CPG2/YscS, conserved site)|interpro:IPR002933(Peptidase M20)|interpro:IPR011650(Peptidase M20, dimerisation)|interpro:IPR017153(Glutathione degradosome, DUG1)|rcsb pdb:4RUH|reactome:R-HSA-174403|refseq:NM_018235.2(identity)|entrezgene/locuslink:55748(identity)	-	isoform-comment:Contains a phosphotyrosine at position 704.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	rogid:qAepmR2WYMtTL3WyP7AZz39LhkM9606	intact-crc:A9C1457C26137961|rigid:oUpj6Zh6GllQnN0/sg+dM/yEDfg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96KP4	uniprotkb:P40763	intact:EBI-1190734|uniprotkb:Q9BQ94|uniprotkb:Q9NVB4|uniprotkb:Q8WY59|uniprotkb:B3KUG4|uniprotkb:V9HWE5|ensembl:ENSP00000325548|ensembl:ENSP00000462311	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:cndp2_human(display_long)|uniprotkb:CNDP dipeptidase 2(gene name synonym)|uniprotkb:Glutamate carboxypeptidase-like protein 1(gene name synonym)|uniprotkb:Peptidase A(gene name synonym)|uniprotkb:HEL-S-13(gene name synonym)|uniprotkb:CNDP2(gene name)|psi-mi:CNDP2(display_short)|uniprotkb:CN2(gene name synonym)|uniprotkb:CPGL(gene name synonym)|uniprotkb:PEPA(gene name synonym)|uniprotkb:Threonyl dipeptidase(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698651|imex:IM-22632-485	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161971.1|refseq:NP_060705.2|refseq:XP_005266785.1|refseq:XP_006722566.1|refseq:XP_011524373.1|refseq:XP_011524374.1|ensembl:ENSG00000133313(gene)|ensembl:ENST00000324262(transcript)|ensembl:ENST00000579847(transcript)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0016805"(dipeptidase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070573"(metallodipeptidase activity)|go:"GO:0103046"(alanylglutamate dipeptidase activity)|interpro:IPR001261(ArgE/DapE/ACY1/CPG2/YscS, conserved site)|interpro:IPR002933(Peptidase M20)|interpro:IPR011650(Peptidase M20, dimerisation)|interpro:IPR017153(Glutathione degradosome, DUG1)|rcsb pdb:4RUH|reactome:R-HSA-174403|refseq:NM_018235.2(identity)|entrezgene/locuslink:55748(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:qAepmR2WYMtTL3WyP7AZz39LhkM9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:21397C097B09788E|rigid:EeVFA+vPfp2yjEEvE9unxjaUx+g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96KP4	uniprotkb:Q9UN19	intact:EBI-1190734|uniprotkb:Q9BQ94|uniprotkb:Q9NVB4|uniprotkb:Q8WY59|uniprotkb:B3KUG4|uniprotkb:V9HWE5|ensembl:ENSP00000325548|ensembl:ENSP00000462311	intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602	psi-mi:cndp2_human(display_long)|uniprotkb:CNDP dipeptidase 2(gene name synonym)|uniprotkb:Glutamate carboxypeptidase-like protein 1(gene name synonym)|uniprotkb:Peptidase A(gene name synonym)|uniprotkb:HEL-S-13(gene name synonym)|uniprotkb:CNDP2(gene name)|psi-mi:CNDP2(display_short)|uniprotkb:CN2(gene name synonym)|uniprotkb:CPGL(gene name synonym)|uniprotkb:PEPA(gene name synonym)|uniprotkb:Threonyl dipeptidase(gene name synonym)	psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698661|imex:IM-22632-486	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161971.1|refseq:NP_060705.2|refseq:XP_005266785.1|refseq:XP_006722566.1|refseq:XP_011524373.1|refseq:XP_011524374.1|ensembl:ENSG00000133313(gene)|ensembl:ENST00000324262(transcript)|ensembl:ENST00000579847(transcript)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0016805"(dipeptidase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070573"(metallodipeptidase activity)|go:"GO:0103046"(alanylglutamate dipeptidase activity)|interpro:IPR001261(ArgE/DapE/ACY1/CPG2/YscS, conserved site)|interpro:IPR002933(Peptidase M20)|interpro:IPR011650(Peptidase M20, dimerisation)|interpro:IPR017153(Glutathione degradosome, DUG1)|rcsb pdb:4RUH|reactome:R-HSA-174403|refseq:NM_018235.2(identity)|entrezgene/locuslink:55748(identity)	refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695|entrezgene/locuslink:27071(identity)|refseq:NM_014395.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:qAepmR2WYMtTL3WyP7AZz39LhkM9606	rogid:YYI49xKbndaB1MfL/QEovp2BF009606	intact-crc:F76E36F6636F9439|rigid:RbB9V5E7PTZdee1v9BKUls8QaYI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:Q96H72-2	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-10698681|ensembl:ENSP00000346956	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:q96h72-2(display_long)|uniprotkb:SLC39A13(gene name)|psi-mi:SLC39A13(display_short)|uniprotkb:LIV-1 subfamily of ZIP zinc transporter 9(gene name synonym)|uniprotkb:Solute carrier family 39 member 13(gene name synonym)|uniprotkb:ZIP13(gene name synonym)|uniprotkb:Zrt- and Irt-like protein 13(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698685|imex:IM-22632-488	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	intact:EBI-10287091(isoform-parent)|ensembl:ENSG00000165915(gene)|ensembl:ENST00000354884(transcript)|refseq:NM_152264.4(identity)|entrezgene/locuslink:91252(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:EVposKOGa/lMNN6K3rgLKh1Cluo9606	intact-crc:6C78114CA36D28F7|rigid:vTy+95oyHwijj6Y5S0QqcG+lLMc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TB24	uniprotkb:Q96IP4	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	intact:EBI-954084|uniprotkb:Q5TF86|uniprotkb:Q8NFZ9|uniprotkb:Q9BW32|uniprotkb:Q9NXV5|uniprotkb:A8K7U4|ensembl:ENSP00000318298	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:tet5a_human(display_long)|uniprotkb:TENT5A(gene name)|psi-mi:TENT5A(display_short)|uniprotkb:C6orf37(gene name synonym)|uniprotkb:FAM46A(gene name synonym)|uniprotkb:HBV X-transactivated gene 11 protein(gene name synonym)|uniprotkb:HBV XAg-transactivated protein 11(gene name synonym)|uniprotkb:XTP11(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698671|imex:IM-22632-487	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	refseq:NP_060103.2|ensembl:ENSG00000112773(gene)|ensembl:ENST00000320172(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0048255"(mRNA stabilization)|go:"GO:1990817"(RNA adenylyltransferase activity)|interpro:IPR012937(Protein of unknown function DUF1693)|entrezgene/locuslink:55603(identity)|refseq:NM_017633.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	rogid:RoYW7NusMegWdnScxOvz6GI6Kjo9606	intact-crc:B79BFB193E466B16|rigid:ryBeAIsfPY+UO8XMY3pksvSYBy4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q96GM5	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-358489|intact:EBI-1760001|ensembl:ENSP00000378414|uniprotkb:Q92924|uniprotkb:Q9Y635|intact:EBI-1965109|uniprotkb:A6NN27|intact:EBI-28976725	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:smrd1_human(display_long)|uniprotkb:SMARCD1(gene name)|psi-mi:SMARCD1(display_short)|uniprotkb:BAF60A(gene name synonym)|uniprotkb:SWI/SNF complex 60 kDa subunit(gene name synonym)|uniprotkb:60 kDa BRG-1/Brm-associated factor subunit A(gene name synonym)|uniprotkb:BRG1-associated factor 60A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698715|imex:IM-22632-491	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	ensembl:ENSG00000066117(gene)|ensembl:ENST00000394963(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048096"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071564"(npBAF complex)|refseq:NP_003067.3|refseq:NP_620710.2|ensembl:ENST00000381513|ensembl:ENSP00000370924|ensembl:ENSP00000378414|go:"GO:0071565"(nBAF complex)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR019835|interpro:IPR036885|interpro:IPR038041|mint:Q96GM5|rcsb pdb:6LTH|rcsb pdb:6LTJ|reactome:R-HSA-3214858|reactome:R-HSA-8939243|dip:DIP-33390N|entrezgene/locuslink:6602(identity)|refseq:NM_003076.4(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:cwqYnl+J8glG8YjW1ps77Dd105Y9606	intact-crc:8E6DBF1DAD3293C4|rigid:m9imRfTPJYPTZXZfsfYi18Ll6PE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96GM5	uniprotkb:P52757	intact:EBI-358489|intact:EBI-1760001|ensembl:ENSP00000378414|uniprotkb:Q92924|uniprotkb:Q9Y635|intact:EBI-1965109|uniprotkb:A6NN27|intact:EBI-28976725	intact:EBI-714925|uniprotkb:Q2M203|uniprotkb:Q75MM2|uniprotkb:A4D1A2|uniprotkb:F8QPL9|ensembl:ENSP00000222792|uniprotkb:E9PGE0|uniprotkb:B3VCF1|uniprotkb:B3VCF2|uniprotkb:B3VCF3|uniprotkb:C9J7B0|uniprotkb:B3VCF7|uniprotkb:B3VCG1	psi-mi:smrd1_human(display_long)|uniprotkb:SMARCD1(gene name)|psi-mi:SMARCD1(display_short)|uniprotkb:BAF60A(gene name synonym)|uniprotkb:SWI/SNF complex 60 kDa subunit(gene name synonym)|uniprotkb:60 kDa BRG-1/Brm-associated factor subunit A(gene name synonym)|uniprotkb:BRG1-associated factor 60A(gene name synonym)	psi-mi:chio_human(display_long)|uniprotkb:Beta-chimerin(gene name synonym)|uniprotkb:Rho GTPase-activating protein 3(gene name synonym)|uniprotkb:CHN2(gene name)|psi-mi:CHN2(display_short)|uniprotkb:ARHGAP3(gene name synonym)|uniprotkb:BCH(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698705|imex:IM-22632-490	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000066117(gene)|ensembl:ENST00000394963(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048096"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071564"(npBAF complex)|refseq:NP_003067.3|refseq:NP_620710.2|ensembl:ENST00000381513|ensembl:ENSP00000370924|ensembl:ENSP00000378414|go:"GO:0071565"(nBAF complex)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR019835|interpro:IPR036885|interpro:IPR038041|mint:Q96GM5|rcsb pdb:6LTH|rcsb pdb:6LTJ|reactome:R-HSA-3214858|reactome:R-HSA-8939243|dip:DIP-33390N|entrezgene/locuslink:6602(identity)|refseq:NM_003076.4(identity)	refseq:NP_001279998.1|refseq:NP_001279999.1|refseq:NP_001280000.1|refseq:NP_001280002.1|refseq:NP_001280004.1|refseq:NP_001280005.1|refseq:NP_001280006.1|refseq:NP_001280007.1|refseq:NP_001280008.1|refseq:NP_001280009.1|refseq:NP_001035025.1|refseq:NP_004058.1|interpro:IPR036860|interpro:IPR037860|mint:P52757|rcsb pdb:1XA6|reactome:R-HSA-9013149|interpro:IPR035840|ensembl:ENSG00000106069(gene)|ensembl:ENST00000222792(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR017356(N-chimaerin)|interpro:IPR020454|entrezgene/locuslink:1124(identity)|refseq:NM_004067.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:cwqYnl+J8glG8YjW1ps77Dd105Y9606	rogid:drcrV4yAbGTuSAJYNjjopBQxFDM9606	intact-crc:3F2C1FD974F9EBA0|rigid:1BKN+tKy1ykj4UBFkGFt6heT8qQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96H72	uniprotkb:Q13387	intact:EBI-10287091|uniprotkb:Q8N7C9|uniprotkb:E9PLY1|uniprotkb:E9PQV3|uniprotkb:Q8WV10|uniprotkb:D3DQR7|uniprotkb:Q659D9|uniprotkb:D3DQR6|ensembl:ENSP00000354689	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:s39ad_human(display_long)|uniprotkb:SLC39A13(gene name)|psi-mi:SLC39A13(display_short)|uniprotkb:LIV-1 subfamily of ZIP zinc transporter 9(gene name synonym)|uniprotkb:Solute carrier family 39 member 13(gene name synonym)|uniprotkb:ZIP13(gene name synonym)|uniprotkb:Zrt- and Irt-like protein 13(gene name synonym)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698695|imex:IM-22632-489	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121697.1|refseq:NP_689477.2|refseq:XP_011518769.1|refseq:XP_011518770.1|ensembl:ENSG00000165915(gene)|ensembl:ENST00000362021(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061448"(connective tissue development)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR003689(Zinc/iron permease)|refseq:NP_001317174.1|refseq:XP_016874029.1|entrezgene/locuslink:91252(identity)|refseq:NM_001128225.2(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:dYUD1ZKiOFqifoqKS8BMljOtnxo9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:9FDB1B0D960EBC88|rigid:XbRwkTHCoUSeCUCLSl+QBRQ5IGA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35568	uniprotkb:Q96FA3	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	intact:EBI-448369|uniprotkb:Q96SM0|uniprotkb:Q9GZY5|uniprotkb:Q9HCX0|ensembl:ENSP00000351789	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:peli1_human(display_long)|uniprotkb:Pellino-related intracellular-signaling molecule(gene name synonym)|uniprotkb:PELI1(gene name)|psi-mi:PELI1(display_short)|uniprotkb:PRISM(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase pellino homolog 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698725|imex:IM-22632-492	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772|refseq:NM_005544.2(identity)|entrezgene/locuslink:3667(identity)	refseq:NP_065702.2|refseq:XP_011531296.1|refseq:XP_016860009.1|dip:DIP-32488N|ensembl:ENSG00000197329(gene)|ensembl:ENST00000358912(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008592"(regulation of Toll signaling pathway)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043331"(response to dsRNA)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR006800(Pellino)|mint:Q96FA3|reactome:R-HSA-5675482|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-975144|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|entrezgene/locuslink:57162(identity)|refseq:NM_020651.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	rogid:GbzrXWXiw4Kv/zN4kEscEKPkEXQ9606	intact-crc:272AA136C5B2FFA2|rigid:H2ErQ9fCP9quFYXfoDguiXizGXQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96DZ7	uniprotkb:Q8TB24	intact:EBI-6448756|ensembl:ENSP00000273695|uniprotkb:E9PH22|uniprotkb:B2RV20|uniprotkb:Q336K7	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	psi-mi:t4s19_human(display_long)|uniprotkb:Osteoclast maturation-associated gene 4 protein(gene name synonym)|uniprotkb:Tetraspan membrane protein OCTM4(gene name synonym)|uniprotkb:TM4SF19(gene name)|psi-mi:TM4SF19(display_short)|uniprotkb:OCTM4(gene name synonym)	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698735|imex:IM-22632-493	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145107(gene)|ensembl:ENST00000273695(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008661(L6 membrane)|refseq:NP_001191827.1|refseq:NP_612470.2|refseq:NM_138461.3(identity)|entrezgene/locuslink:116211(identity)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:0pi3aVpxzi5UX4o8+w7qSluVefU9606	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	intact-crc:B3EAE0AA6B3D4D41|rigid:kheuEOWYYKznLr7lBxhtOiXbbn4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q96DX5	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-745641|uniprotkb:Q9NWS5|uniprotkb:Q9Y4T3|uniprotkb:A8K8A5|ensembl:ENSP00000369855|intact:EBI-2349899|uniprotkb:Q9BVF5	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:asb9_human(display_long)|uniprotkb:ASB9(gene name)|psi-mi:ASB9(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698765|imex:IM-22632-496	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_001026909.1|refseq:NP_001162003.1|refseq:NP_076992.1|ensembl:ENST00000380488(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045732"(positive regulation of protein catabolic process)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036036|interpro:IPR036770|interpro:IPR037333|mint:Q96DX5|rcsb pdb:3D9H|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:6V9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000102048(gene)|refseq:NP_001162002.1|refseq:XP_005274503.1|dip:DIP-52905N|entrezgene/locuslink:140462(identity)|refseq:NM_001031739.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:ptKNzNqGuV3MO9/nIT6RI+w/Jtk9606	intact-crc:12AA94CB7BC168E9|rigid:nxazHMoQanwtG5tUYyAW6f0pLUs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96DZ7	uniprotkb:Q9UN19	intact:EBI-6448756|ensembl:ENSP00000273695|uniprotkb:E9PH22|uniprotkb:B2RV20|uniprotkb:Q336K7	intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602	psi-mi:t4s19_human(display_long)|uniprotkb:Osteoclast maturation-associated gene 4 protein(gene name synonym)|uniprotkb:Tetraspan membrane protein OCTM4(gene name synonym)|uniprotkb:TM4SF19(gene name)|psi-mi:TM4SF19(display_short)|uniprotkb:OCTM4(gene name synonym)	psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698745|imex:IM-22632-494	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145107(gene)|ensembl:ENST00000273695(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008661(L6 membrane)|refseq:NP_001191827.1|refseq:NP_612470.2|refseq:NM_138461.3(identity)|entrezgene/locuslink:116211(identity)	refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695|entrezgene/locuslink:27071(identity)|refseq:NM_014395.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:0pi3aVpxzi5UX4o8+w7qSluVefU9606	rogid:YYI49xKbndaB1MfL/QEovp2BF009606	intact-crc:77F7EF8788FC9387|rigid:UnH78GjPZIn/pmGZUU2YRtLA4+8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16885	uniprotkb:Q96DX5	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	intact:EBI-745641|uniprotkb:Q9NWS5|uniprotkb:Q9Y4T3|uniprotkb:A8K8A5|ensembl:ENSP00000369855|intact:EBI-2349899|uniprotkb:Q9BVF5	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:asb9_human(display_long)|uniprotkb:ASB9(gene name)|psi-mi:ASB9(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698755|imex:IM-22632-495	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	refseq:NP_001026909.1|refseq:NP_001162003.1|refseq:NP_076992.1|ensembl:ENST00000380488(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045732"(positive regulation of protein catabolic process)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036036|interpro:IPR036770|interpro:IPR037333|mint:Q96DX5|rcsb pdb:3D9H|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:6V9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000102048(gene)|refseq:NP_001162002.1|refseq:XP_005274503.1|dip:DIP-52905N|entrezgene/locuslink:140462(identity)|refseq:NM_001031739.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	rogid:ptKNzNqGuV3MO9/nIT6RI+w/Jtk9606	intact-crc:0FB0EF1028816A59|rigid:iaJqroLUH3Bdte4vuZ3W6pal21Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92913	uniprotkb:Q13387	intact:EBI-1054883|uniprotkb:O95830|uniprotkb:B1AK18|uniprotkb:D3DWH4|uniprotkb:Q9NZH9|uniprotkb:Q9NZI0|uniprotkb:B7Z4M7|uniprotkb:B7Z8N0|ensembl:ENSP00000322390	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:fgf13_human(display_long)|uniprotkb:Fibroblast growth factor homologous factor 2(gene name synonym)|uniprotkb:FGF13(gene name)|psi-mi:FGF13(display_short)|uniprotkb:FHF2(gene name synonym)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698789|imex:IM-22632-498	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001132970.1|refseq:NP_001132972.1|refseq:NP_001132973.1|refseq:NP_001132974.1|refseq:NP_004105.1|refseq:NP_378668.1|refseq:XP_005262456.1|ensembl:ENST00000315930(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|ensembl:ENSG00000129682(gene)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0008083"(growth factor activity)|go:"GO:0014704"(intercalated disc)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0021766"(hippocampus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0030175"(filopodium)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0043005"(neuron projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1904862"(inhibitory synapse assembly)|go:"GO:1905150"(regulation of voltage-gated sodium channel activity)|go:"GO:1990834"(response to odorant)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028279|rcsb pdb:3HBW|rcsb pdb:4DCK|rcsb pdb:4JPZ|reactome:R-HSA-5576892|go:"GO:0048671"(negative regulation of collateral sprouting)|dip:DIP-50447N|refseq:NM_004114.3(identity)|entrezgene/locuslink:2258(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:W8pxNB28t+6D+XC7zhXyBn4P6yQ9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:A5469C92BAED122D|rigid:iXxHdlWrk/n2vzjh8gbS8sqei4w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60880	uniprotkb:Q96AQ1-2	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-10698775|ensembl:ENSP00000387009	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:q96aq1-2(display_long)|uniprotkb:CCDC74A(gene name)|psi-mi:CCDC74A(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698779|imex:IM-22632-497	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N|entrezgene/locuslink:4068(identity)|refseq:NM_002351.4(identity)	intact:EBI-8466689(isoform-parent)|ensembl:ENSG00000163040(gene)|ensembl:ENST00000409856(transcript)|entrezgene/locuslink:90557(identity)|refseq:NM_001258306.1(identity)	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:Pb/BQJ4Mk7QnJ8DhEmtIL4dFBX89606	intact-crc:193D5993299DA48C|rigid:nslVep/KMZyJ6Bl8MzcQCn+szU4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92797	uniprotkb:Q8TB24	intact:EBI-1051992|uniprotkb:O00521|uniprotkb:O00689|uniprotkb:O00733|uniprotkb:Q59GT5|uniprotkb:Q8N2U5|ensembl:ENSP00000245934	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	psi-mi:sympk_human(display_long)|uniprotkb:SYMPK(gene name)|psi-mi:SYMPK(display_short)|uniprotkb:SPK(gene name synonym)	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698799|imex:IM-22632-499	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016604"(nuclear body)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0097165"(nuclear stress granule)|ensembl:ENSG00000125755(gene)|ensembl:ENST00000245934(transcript)|interpro:IPR011989(Armadillo-like helical)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021850|interpro:IPR022075|interpro:IPR032460|mint:Q92797|rcsb pdb:3O2Q|rcsb pdb:3O2S|rcsb pdb:3O2T|rcsb pdb:3ODR|go:"GO:0005829"(cytosol)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007155"(cell adhesion)|refseq:NP_004810.2|refseq:XP_011525656.1|refseq:XP_005259343.1|dip:DIP-42506N|rcsb pdb:3ODS|rcsb pdb:4H3H|rcsb pdb:4H3K|rcsb pdb:6V4X|reactome:R-HSA-159231|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|refseq:NM_004819.2(identity)|entrezgene/locuslink:8189(identity)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:+svYKfmD5gCiOxf9FxGUZKCNhtQ9606	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	intact-crc:303EBFF14233B74A|rigid:Ac7aGlRw3CNMsfhIQnh+2+dNPZI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEU8	uniprotkb:Q92574	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698809|imex:IM-22632-500	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1|entrezgene/locuslink:7248(identity)|refseq:NM_001162426.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:7B09494BC0B6EB98|rigid:pwXEyoPE3l8dfHN3ppqOctzy4kw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P104-2	uniprotkb:Q92574	intact:EBI-10692909|ensembl:ENSP00000379270	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:q9p104-2(display_long)|uniprotkb:DOK5(gene name)|psi-mi:DOK5(display_short)|uniprotkb:C20orf180(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 5(gene name synonym)|uniprotkb:Insulin receptor substrate 6(gene name synonym)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698829|imex:IM-22632-502	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101134(gene)|ensembl:ENST00000395939(transcript)|intact:EBI-739600(isoform-parent)|uniprotkb:Q9P104-2(isoform-parent)|refseq:NM_177959.2(identity)|entrezgene/locuslink:55816(identity)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1|entrezgene/locuslink:7248(identity)|refseq:NM_001162426.1(identity)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8p18JpE/uszPiQyb4FtcEu5QiOc9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:D774B7908554D223|rigid:WyU/YDrRUUf2lEqcFbwMn7AI9Vk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92574	uniprotkb:Q8TB24	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698819|imex:IM-22632-501	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1|entrezgene/locuslink:7248(identity)|refseq:XM_006717272.1(identity)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	intact-crc:F282B2FCA123CE9A|rigid:59vtjbowBU3covT+kBOo2YAeq54	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16591	uniprotkb:Q92569	intact:EBI-1380661|uniprotkb:B4DSQ2|uniprotkb:B2RCR4|uniprotkb:H2FLB8|ensembl:ENSP00000281092	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:fer_human(display_long)|uniprotkb:Feline encephalitis virus-related kinase FER(gene name synonym)|uniprotkb:Fujinami poultry sarcoma/Feline sarcoma-related protein Fer(gene name synonym)|uniprotkb:FER(gene name)|psi-mi:FER(display_short)|uniprotkb:TYK3(gene name synonym)|uniprotkb:Proto-oncogene c-Fer(gene name synonym)|uniprotkb:Tyrosine kinase 3(gene name synonym)|uniprotkb:p94-Fer(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698839|imex:IM-22632-503	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005237.2|refseq:XP_016864719.1|refseq:XP_016864720.1|refseq:NP_001294957.1|refseq:NP_001294960.1|refseq:NP_001294967.1|refseq:XP_011541573.1|ensembl:ENSG00000151422(gene)|ensembl:ENST00000281092(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033007"(negative regulation of mast cell activation involved in immune response)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0036119"(response to platelet-derived growth factor)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038109"(Kit signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050904"(diapedesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR028539|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|interpro:IPR037452|mint:P16591|rcsb pdb:2KK6|rcsb pdb:6KC4|reactome:R-HSA-1433557|entrezgene/locuslink:2241(identity)|refseq:NM_005246.2(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:De5RYVRGihPHGxaflmxR8W9jC8M9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:DE2DA39B220065E0|rigid:i9VAStmYgb2bmI205qwC+vGiZk8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WYA6-3	uniprotkb:Q13387	intact:EBI-10698849|ensembl:ENSP00000362568	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:q8wya6-3(display_long)|uniprotkb:CTNNBL1(gene name)|psi-mi:CTNNBL1(display_short)|uniprotkb:C20orf33(gene name synonym)|uniprotkb:Nuclear-associated protein(gene name synonym)|uniprotkb:Testis development protein NYD-SP19(gene name synonym)|uniprotkb:PP8304(orf name)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698853|imex:IM-22632-504	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-748128(isoform-parent)|ensembl:ENSG00000132792(gene)|ensembl:ENST00000373469(transcript)|entrezgene/locuslink:56259(identity)|refseq:NM_001281495.1(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	isoform-comment:Gene prediction based on EST data.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:UdQgMi7QI/kDCLFOlWO9emzQ4ek9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:192950CF1D856EBA|rigid:i0U4+IaHCptnEu9zI36gsMddSuM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43559	uniprotkb:Q8WXH5	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698863|imex:IM-22632-505	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	intact-crc:7C42C8F643885D07|rigid:SYCyk0/sOI62Rt87FHOtxHvsCT4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16885	uniprotkb:Q8WVJ9	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	intact:EBI-1797313|uniprotkb:Q3SYL6|ensembl:ENSP00000405176|ensembl:ENSP00000482581|ensembl:ENSP00000500440|ensembl:ENSP00000500609	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:twst2_human(display_long)|uniprotkb:Dermis-expressed protein 1(gene name synonym)|uniprotkb:TWIST2(gene name)|psi-mi:TWIST2(display_short)|uniprotkb:DERMO1(gene name synonym)|uniprotkb:BHLHA39(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 39(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698873|imex:IM-22632-506	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	refseq:NP_001258822.1|refseq:NP_476527.1|ensembl:ENSG00000233608(gene)|ensembl:ENSG00000288335(gene)|ensembl:ENST00000448943(transcript)|ensembl:ENST00000612363(transcript)|ensembl:ENST00000671947(transcript)|ensembl:ENST00000673387(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032502"(developmental process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015789(Twist)|interpro:IPR036638|reactome:R-HSA-8878166|entrezgene/locuslink:117581(identity)|refseq:NM_057179.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	rogid:IYIpMXYdrqllQqS+Ftz+P0xtk789606	intact-crc:B680FB85874ED617|rigid:By9jXw/pM0uV9EE1X3kwFWerDj4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q8WVJ9	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-1797313|uniprotkb:Q3SYL6|ensembl:ENSP00000405176|ensembl:ENSP00000482581|ensembl:ENSP00000500440|ensembl:ENSP00000500609	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:twst2_human(display_long)|uniprotkb:Dermis-expressed protein 1(gene name synonym)|uniprotkb:TWIST2(gene name)|psi-mi:TWIST2(display_short)|uniprotkb:DERMO1(gene name synonym)|uniprotkb:BHLHA39(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 39(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698883|imex:IM-22632-507	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_001258822.1|refseq:NP_476527.1|ensembl:ENSG00000233608(gene)|ensembl:ENSG00000288335(gene)|ensembl:ENST00000448943(transcript)|ensembl:ENST00000612363(transcript)|ensembl:ENST00000671947(transcript)|ensembl:ENST00000673387(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032502"(developmental process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015789(Twist)|interpro:IPR036638|reactome:R-HSA-8878166|entrezgene/locuslink:117581(identity)|refseq:NM_057179.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:IYIpMXYdrqllQqS+Ftz+P0xtk789606	intact-crc:F747A4E8CA43A1A3|rigid:BIGfpC6ZBzQ1SLcHSS96QD8Ummo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763-2	uniprotkb:Q8WVB6	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	intact:EBI-1237523|uniprotkb:Q7Z6Y6|uniprotkb:Q9BR83|uniprotkb:Q9BRG5|uniprotkb:Q9H7K3|uniprotkb:B7ZBA2|uniprotkb:Q7Z6Y4|uniprotkb:D3DU68|intact:EBI-28984493|ensembl:ENSP00000262315	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:ctf18_human(display_long)|uniprotkb:CHTF18(gene name)|psi-mi:CHTF18(display_short)|uniprotkb:CTF18(gene name synonym)|uniprotkb:C16orf41(gene name synonym)|uniprotkb:CHL12(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698893|imex:IM-22632-508	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_071375.1|refseq:XP_011520875.1|ensembl:ENSP00000262315|ensembl:ENST00000455171|ensembl:ENSP00000406252|refseq:XP_005255528.1|ensembl:ENSG00000127586(gene)|ensembl:ENST00000262315(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0031390"(Ctf18 RFC-like complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR027417|mint:Q8WVB6|reactome:R-HSA-174411|entrezgene/locuslink:63922(identity)|refseq:NM_022092.2(identity)	-	isoform-comment:Contains a phosphotyrosine at position 704.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	rogid:cIuesMN9KfDCiavKy3XvnYV+IA09606	intact-crc:04D0DE3E4FE91D11|rigid:2scHwgPk00ewTwNwX/8gp3wwJu0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:Q8WVB6	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-1237523|uniprotkb:Q7Z6Y6|uniprotkb:Q9BR83|uniprotkb:Q9BRG5|uniprotkb:Q9H7K3|uniprotkb:B7ZBA2|uniprotkb:Q7Z6Y4|uniprotkb:D3DU68|intact:EBI-28984493|ensembl:ENSP00000262315	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:ctf18_human(display_long)|uniprotkb:CHTF18(gene name)|psi-mi:CHTF18(display_short)|uniprotkb:CTF18(gene name synonym)|uniprotkb:C16orf41(gene name synonym)|uniprotkb:CHL12(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698903|imex:IM-22632-509	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_071375.1|refseq:XP_011520875.1|ensembl:ENSP00000262315|ensembl:ENST00000455171|ensembl:ENSP00000406252|refseq:XP_005255528.1|ensembl:ENSG00000127586(gene)|ensembl:ENST00000262315(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0031390"(Ctf18 RFC-like complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR027417|mint:Q8WVB6|reactome:R-HSA-174411|entrezgene/locuslink:63922(identity)|refseq:NM_022092.2(identity)	-	crc64:6C00632211C8012D	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:cIuesMN9KfDCiavKy3XvnYV+IA09606	intact-crc:43F384BF966D80EC|rigid:CF4JdfgCyyvZUIZFCYK+mZIjtWE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q8WUW1	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-2837444|uniprotkb:Q9P082|uniprotkb:B2R5E2|ensembl:ENSP00000432472	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:brk1_human(display_long)|uniprotkb:C3orf10(gene name synonym)|uniprotkb:BRK1(gene name)|psi-mi:BRK1(display_short)|uniprotkb:HSPC300(orf name)|uniprotkb:MDS027(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698913|imex:IM-22632-510	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_060932.2|dip:DIP-41554N|ensembl:ENSG00000254999(gene)|ensembl:ENST00000530758(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048870"(cell motility)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR033378|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NM_018462.4(identity)|entrezgene/locuslink:55845(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:IZ0oK9Z3VxULlM+igusbB5mwyyo9606	intact-crc:AE692A22ECCBD94B|rigid:418UEA7J8QNEoCCauYup0pLXZjk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TAK5	uniprotkb:P16885	intact:EBI-8468945|intact:MINT-6778891|uniprotkb:D3DV14|uniprotkb:B1AVJ8|uniprotkb:Q8NAR5|ensembl:ENSP00000357914	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	psi-mi:gabp2_human(display_long)|uniprotkb:GABPB2(gene name)|psi-mi:GABPB2(display_short)	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698933|imex:IM-22632-512	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001310837.1|refseq:NP_653219.1|refseq:XP_016855738.1|ensembl:ENSG00000143458(gene)|ensembl:ENST00000368918(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q8TAK5|entrezgene/locuslink:126626(identity)|refseq:NM_144618.2(identity)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	-	function:"May function as transcription factor capable of interacting with purine rich repeats (GA repeats)"|comment:mint|comment:homomint	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:F1UTCglE16qDpbAHMtdpL/zq8XY9606	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	intact-crc:141FCA7BE515150E|rigid:QxMdM9Uh1v8omFcxjxnQZpBnSBY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:Q8NEJ0	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-10698945|uniprotkb:B3KPA4|ensembl:ENSP00000333917|ensembl:ENSP00000366291|ensembl:ENSP00000385463|ensembl:ENSP00000386063	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:dus18_human(display_long)|uniprotkb:DUSP18(gene name)|psi-mi:DUSP18(display_short)|uniprotkb:LMWDSP20(gene name synonym)|uniprotkb:Low molecular weight dual specificity phosphatase 20(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698943|imex:IM-22632-513	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	refseq:NP_689724.3|refseq:XP_005261425.1|refseq:XP_006724211.1|refseq:NP_001291723.1|refseq:NP_001291724.1|refseq:XP_011528222.1|refseq:XP_011528223.1|ensembl:ENSG00000167065(gene)|ensembl:ENST00000334679(transcript)|ensembl:ENST00000377087(transcript)|ensembl:ENST00000404885(transcript)|ensembl:ENST00000407308(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017017"(MAP kinase tyrosine/serine/threonine phosphatase activity)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020420|interpro:IPR020422|interpro:IPR029021|mint:Q8NEJ0|rcsb pdb:2ESB|refseq:XP_016884116.1|refseq:XP_016884117.1|refseq:NM_152511.3(identity)|entrezgene/locuslink:150290(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:kSGwIoocrefd/mtE3eFcn0NqY6k9606	intact-crc:0FB1002C29CC551D|rigid:2wYJVNNXWkZ3KqDEaFnHquPjHyU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UN19	uniprotkb:Q8TDB4	intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602	intact:EBI-4397720|uniprotkb:Q9BZC3|ensembl:ENSP00000381928	psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name)	psi-mi:hummr_human(display_long)|uniprotkb:MGARP(gene name)|psi-mi:MGARP(display_short)|uniprotkb:C4orf49(gene name synonym)|uniprotkb:CESP1(gene name synonym)|uniprotkb:Corneal endothelium-specific protein 1(gene name synonym)|uniprotkb:HUMMR(gene name synonym)|uniprotkb:Hypoxia up-regulated mitochondrial movement regulator protein(gene name synonym)|uniprotkb:Mitochondria-localized glutamic acid-rich protein(gene name synonym)|uniprotkb:OSAP(gene name synonym)|uniprotkb:Ovary-specific acidic protein(gene name synonym)|uniprotkb:GS3582(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698923|imex:IM-22632-511	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695|entrezgene/locuslink:27071(identity)|refseq:NM_014395.2(identity)	refseq:NP_116012.2|ensembl:ENSG00000137463(gene)|ensembl:ENST00000398955(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097211"(cellular response to gonadotropin-releasing hormone)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR026093|interpro:IPR032773|entrezgene/locuslink:84709(identity)|refseq:NM_032623.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:YYI49xKbndaB1MfL/QEovp2BF009606	rogid:MMN6ncFfmsKMYnZ4EpKUtlhvW5E9606	intact-crc:DC14213E3117BF6F|rigid:DmuaVHJe9JWtWDE5JyyMXDDz3mk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q8NEC7	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-8469616|intact:MINT-6779113|uniprotkb:Q9H8S3|uniprotkb:A8MVD3|uniprotkb:A8K8J0|uniprotkb:H9KV97|ensembl:ENSP00000353695|ensembl:ENSP00000378216|ensembl:ENSP00000422354	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:gstcd_human(display_long)|uniprotkb:GSTCD(gene name)|psi-mi:GSTCD(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698958|imex:IM-22632-514	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	refseq:XP_011530550.1|refseq:XP_011530551.1|refseq:XP_011530554.1|refseq:NP_001026890.2|refseq:NP_079027.2|refseq:XP_005263279.1|ensembl:ENSG00000138780(gene)|ensembl:ENST00000360505(transcript)|ensembl:ENST00000394728(transcript)|ensembl:ENST00000515279(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR025714|interpro:IPR029063|interpro:IPR036282|mint:Q8NEC7|entrezgene/locuslink:79807(identity)|refseq:NM_001031720.3(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	comment:mint|comment:homomint	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:jg34D624i8iGCgGTedM+tfGgmRQ9606	intact-crc:9695DF72EC05098F|rigid:jLqsZfVSb4S2EXXccW1B30f3eVE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16885	uniprotkb:Q8NE22	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	intact:EBI-10698970|uniprotkb:F5H713|ensembl:ENSP00000285947	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:setd9_human(display_long)|uniprotkb:SETD9(gene name)|psi-mi:SETD9(display_short)|uniprotkb:C5orf35(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698968|imex:IM-22632-515	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	refseq:NP_001165461.1|refseq:NP_714917.2|ensembl:ENSG00000155542(gene)|ensembl:ENST00000285947(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016278"(lysine N-methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001214(SET)|interpro:IPR040415|reactome:R-HSA-6804760|refseq:NM_153706.3(identity)|entrezgene/locuslink:133383(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	rogid:kMznPR6OQfHWcshDHeGDNQ2I6HA9606	intact-crc:B0295F1F4D2A3D3C|rigid:Ci6K4XH72eMacOWHeWIHuJMjrPk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NBZ0	uniprotkb:P46108-2	intact:EBI-769401|uniprotkb:Q6Y2K3|intact:EBI-28973946|ensembl:ENSP00000457016	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:in80e_human(display_long)|uniprotkb:CCDC95(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 95(gene name synonym)|uniprotkb:INO80E(gene name)|psi-mi:INO80E(display_short)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698993|imex:IM-22632-517	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_775889.1|ensembl:ENST00000562441|ensembl:ENSP00000456073|ensembl:ENSP00000457016|ensembl:ENST00000567065|ensembl:ENSP00000454665|ensembl:ENST00000620599|ensembl:ENSP00000484187|refseq:NP_001291491.1|refseq:NP_001291492.1|ensembl:ENSG00000169592(gene)|ensembl:ENST00000563197(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0031011"(Ino80 complex)|interpro:IPR026678|mint:Q8NBZ0|reactome:R-HSA-5689603|reactome:R-HSA-5696394|refseq:NM_173618.1(identity)|entrezgene/locuslink:283899(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:gGBXpYQkxY5mcF4I/4rTzjXZbG09606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:FAFAE3BC5003533A|rigid:48h4tnfxLPj7BxEmdEsor3TEx14	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q8NE22	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-10698970|uniprotkb:F5H713|ensembl:ENSP00000285947	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:setd9_human(display_long)|uniprotkb:SETD9(gene name)|psi-mi:SETD9(display_short)|uniprotkb:C5orf35(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10698983|imex:IM-22632-516	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_001165461.1|refseq:NP_714917.2|ensembl:ENSG00000155542(gene)|ensembl:ENST00000285947(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016278"(lysine N-methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001214(SET)|interpro:IPR040415|reactome:R-HSA-6804760|refseq:NM_153706.3(identity)|entrezgene/locuslink:133383(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:kMznPR6OQfHWcshDHeGDNQ2I6HA9606	intact-crc:E83F919C22DC0DF6|rigid:HrU9pOaJkFdMasL5vYGFxDBL0OE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N988-2	uniprotkb:P46108-2	intact:EBI-10699005|ensembl:ENSP00000252840	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:q8n988-2(display_long)|uniprotkb:ZNF557(gene name)|psi-mi:ZNF557(display_short)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699017|imex:IM-22632-519	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:Q8N988-2(isoform-parent)|intact:EBI-7247742(isoform-parent)|ensembl:ENSG00000130544(gene)|ensembl:ENST00000252840(transcript)|refseq:NM_001044387.1(identity)|entrezgene/locuslink:79230(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MjTySoeOCk6/JdHvn9mSWmqNbv49606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:983B69D850B7FD0F|rigid:9m4VSm+4+lzqdjaCQuTn55BHDn0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N988-2	uniprotkb:P40763	intact:EBI-10699005|ensembl:ENSP00000252840	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:q8n988-2(display_long)|uniprotkb:ZNF557(gene name)|psi-mi:ZNF557(display_short)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699003|imex:IM-22632-518	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:Q8N988-2(isoform-parent)|intact:EBI-7247742(isoform-parent)|ensembl:ENSG00000130544(gene)|ensembl:ENST00000252840(transcript)|refseq:NM_001044387.1(identity)|entrezgene/locuslink:79230(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MjTySoeOCk6/JdHvn9mSWmqNbv49606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:4504A81AF7EF6F40|rigid:uuPMoU4GsbKRoQi/H+/ggz9lBXA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q8N7B6-2	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-10694433|ensembl:ENSP00000295290|ensembl:ENSP00000354171|ensembl:ENSP00000423477|ensembl:ENSP00000423536|ensembl:ENSP00000425938	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:q8n7b6-2(display_long)|uniprotkb:PACRGL(gene name)|psi-mi:PACRGL(display_short)|uniprotkb:C4orf28(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699027|imex:IM-22632-520	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	ensembl:ENSG00000163138(gene)|ensembl:ENST00000295290(transcript)|ensembl:ENST00000360916(transcript)|ensembl:ENST00000467997(transcript)|ensembl:ENST00000506702(transcript)|ensembl:ENST00000507634(transcript)|intact:EBI-3925298(isoform-parent)|uniprotkb:Q8N7B6-2(isoform-parent)|entrezgene/locuslink:133015(identity)|refseq:NM_145048.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:ggQEVTS6If4Zi1nkqpe4Lg/Ages9606	intact-crc:13508D344433C6DF|rigid:Ak6bfwMt3mxrwv4QkDj3T1HEu1s	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N720	uniprotkb:Q8TB24	intact:EBI-625509|ensembl:ENSP00000252713|ensembl:ENSP00000377718|uniprotkb:Q8IV00|uniprotkb:Q8TA89|uniprotkb:Q96EZ3|uniprotkb:A4D291|uniprotkb:B4E3M4|uniprotkb:B7Z9Q9|intact:EBI-741438|uniprotkb:Q9BQ85|uniprotkb:D6W5T4|uniprotkb:A6NGD3	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	psi-mi:zn655_human(display_long)|uniprotkb:Vav-interacting Krueppel-like protein(gene name synonym)|uniprotkb:ZNF655(gene name)|psi-mi:ZNF655(display_short)|uniprotkb:VIK(gene name synonym)	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699037|imex:IM-22632-521	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000197343(gene)|ensembl:ENST00000252713(transcript)|ensembl:ENST00000394163(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-HSA-212436|refseq:NP_001009960.1|refseq:NP_001077425.1|refseq:NP_001078835.1|refseq:NP_001078836.1|refseq:NP_001078837.1|refseq:NP_076966.1|refseq:NP_612503.1|refseq:NP_001009958.1|refseq:XP_016868092.1|refseq:XP_016868093.1|refseq:XP_016868095.1|refseq:XP_016868096.1|dip:DIP-34108N|entrezgene/locuslink:79027(identity)|refseq:NM_001009960.1(identity)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:kz0A7h281PEWFM7dsPGoPyTAMgs9606	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	intact-crc:13F9347B13C5649B|rigid:SpdPgBf6wnMBzLtjS1dlgOveQj4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96IW2	uniprotkb:Q8N6L1-2	intact:EBI-4402781|uniprotkb:Q96NC2|ensembl:ENSP00000446058	intact:EBI-10699047	psi-mi:shd_human(display_long)|uniprotkb:SHD(gene name)|psi-mi:SHD(display_short)	psi-mi:q8n6l1-2(display_long)|uniprotkb:KRTCAP2(gene name)|psi-mi:KRTCAP2(display_short)|uniprotkb:KCP2(gene name synonym)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699051|imex:IM-22632-522	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064594.3|ensembl:ENSG00000105251(gene)|go:"GO:0001784"(phosphotyrosine residue binding)|interpro:IPR000980(SH2 motif)|interpro:IPR035039|interpro:IPR035046|interpro:IPR036860|ensembl:ENST00000543264(transcript)|entrezgene/locuslink:56961(identity)|refseq:NM_020209.3(identity)	intact:EBI-1053775(isoform-parent)|entrezgene/locuslink:200185(identity)|refseq:NM_173852.3(identity)	-	-	isoform-comment:Produced at low levels due to suboptimal Kozak context.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:c2PsXxVdBB1dLj+Lu40XdgOb2yY9606	rogid:+ZvuqXNBQYqonkgCD5s8Vi5ZJ5I9606	intact-crc:7A1758126A348FD9|rigid:G5e8GdK0P9AJbuPn5mZhJEQV0uo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N6F8	uniprotkb:P62993	intact:EBI-8487781|intact:MINT-8417729|ensembl:ENSP00000297873	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:met27_human(display_long)|uniprotkb:METTL27(gene name)|psi-mi:METTL27(display_short)|uniprotkb:WBSCR27(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 27 protein(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699061|imex:IM-22632-523	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_689772.2|ensembl:ENSG00000165171(gene)|ensembl:ENST00000297873(transcript)|go:"GO:0008168"(methyltransferase activity)|interpro:IPR029063|interpro:IPR041698|mint:Q8N6F8|refseq:NM_152559.2(identity)|entrezgene/locuslink:155368(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	comment:mint|comment:homomint	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:T+4JBqFxUvWNzHLf1bT6SGLCaJs9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:8D466795CE878EC8|rigid:1bdNnqdEkKNsSURIqImIGzOa4o4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60880	uniprotkb:Q8N5V2	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-718372|uniprotkb:B9A045|uniprotkb:Q53QQ4|uniprotkb:Q53ST7|uniprotkb:Q6GMQ5|uniprotkb:Q9NQD6|uniprotkb:B4DMB8|uniprotkb:E9PC42|ensembl:ENSP00000264051	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:ngef_human(display_long)|uniprotkb:Eph-interacting exchange protein(gene name synonym)|uniprotkb:Neuronal guanine nucleotide exchange factor(gene name synonym)|uniprotkb:NGEF(gene name)|psi-mi:NGEF(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699071|imex:IM-22632-524	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N|entrezgene/locuslink:4068(identity)|refseq:NM_002351.4(identity)	refseq:NP_001107562.1|refseq:NP_062824.2|refseq:XP_011509225.1|ensembl:ENSG00000066248(gene)|ensembl:ENST00000264051(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030426"(growth cone)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035635|interpro:IPR035899|interpro:IPR036028|mint:Q8N5V2|reactome:R-HSA-193648|reactome:R-HSA-3928663|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|go:"GO:0005829"(cytosol)|entrezgene/locuslink:25791(identity)|refseq:NM_019850.2(identity)	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:oAu+8njDslYpqxQaq85zzC3hb209606	intact-crc:B18EBB64D9401936|rigid:LLIdTpXao5VxxCpSToLxI2RceT0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N5R6-5	uniprotkb:Q92569	intact:EBI-10699081|ensembl:ENSP00000268082|ensembl:ENSP00000500272	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:q8n5r6-5(display_long)|uniprotkb:CCDC33(gene name)|psi-mi:CCDC33(display_short)|uniprotkb:Cancer/testis antigen 61(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699085|imex:IM-22632-525	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140481(gene)|ensembl:ENSG00000288407(gene)|ensembl:ENST00000268082(transcript)|ensembl:ENST00000673214(transcript)|intact:EBI-740841(isoform-parent)|uniprotkb:Q8N5R6-5(isoform-parent)|entrezgene/locuslink:80125(identity)|refseq:NM_182791.3(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:7gA6QMcGylnLySq/4z/MN4AD5aw9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:02117B244954CBAD|rigid:Zs0ZqNOlolORZBBqxg2ctsDKYiQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75052	uniprotkb:Q8N488	intact:EBI-780467|uniprotkb:B7ZLF5|uniprotkb:Q3T551|uniprotkb:O43564|uniprotkb:Q5VU95|ensembl:ENSP00000355133	intact:EBI-752324|uniprotkb:Q9P2W5|uniprotkb:Q9UMW4|ensembl:ENSP00000419494	psi-mi:capon_human(display_long)|uniprotkb:C-terminal PDZ ligand of neuronal nitric oxide synthase protein(gene name synonym)|uniprotkb:Nitric oxide synthase 1 adaptor protein(gene name synonym)|uniprotkb:NOS1AP(gene name)|psi-mi:NOS1AP(display_short)|uniprotkb:CAPON(gene name synonym)|uniprotkb:KIAA0464(gene name synonym)	psi-mi:rybp_human(display_long)|uniprotkb:Death effector domain-associated factor(gene name synonym)|uniprotkb:YY1 and E4TF1-associated factor 1(gene name synonym)|uniprotkb:Apoptin-associating protein 1(gene name synonym)|uniprotkb:RYBP(gene name)|psi-mi:RYBP(display_short)|uniprotkb:DEDAF(gene name synonym)|uniprotkb:YEAF1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699105|imex:IM-22632-527	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119532.2|refseq:NP_001158229.1|refseq:NP_055512.1|ensembl:ENSG00000198929(gene)|ensembl:ENST00000361897(transcript)|go:"GO:0003062"(regulation of heart rate by chemical signal)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903762"(positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:2000170"(positive regulation of peptidyl-cysteine S-nitrosylation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|entrezgene/locuslink:9722(identity)|refseq:NM_014697.2(identity)	refseq:NP_036366.3|dip:DIP-41435N|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR033774|interpro:IPR036443|interpro:IPR039958|mint:Q8N488|rcsb pdb:3IXS|reactome:R-HSA-8939243|reactome:R-HSA-8953750|ensembl:ENSG00000163602(gene)|ensembl:ENST00000477973(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|entrezgene/locuslink:23429(identity)|refseq:NM_012234.6(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:bpv0yuTlHR7wYE9SJ4krek2gJXQ9606	rogid:t9ef8aO/5xEAB3hMlElJCktEIOU9606	intact-crc:7EF1532A4FC08226|rigid:z+7pmwcOF6lfxZvDnMRVlMNv1hk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N5F7	uniprotkb:O75052	intact:EBI-721539|uniprotkb:Q96BQ2|uniprotkb:Q9H638|intact:EBI-745962|intact:EBI-1055594|uniprotkb:Q6IPW6|ensembl:ENSP00000360464	intact:EBI-780467|uniprotkb:B7ZLF5|uniprotkb:Q3T551|uniprotkb:O43564|uniprotkb:Q5VU95|ensembl:ENSP00000355133	psi-mi:nkap_human(display_long)|uniprotkb:NKAP(gene name)|psi-mi:NKAP(display_short)	psi-mi:capon_human(display_long)|uniprotkb:C-terminal PDZ ligand of neuronal nitric oxide synthase protein(gene name synonym)|uniprotkb:Nitric oxide synthase 1 adaptor protein(gene name synonym)|uniprotkb:NOS1AP(gene name)|psi-mi:NOS1AP(display_short)|uniprotkb:CAPON(gene name synonym)|uniprotkb:KIAA0464(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699095|imex:IM-22632-526	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078804.2|ensembl:ENSG00000101882(gene)|ensembl:ENST00000371410(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|interpro:IPR009269(Protein of unknown function DUF926)|interpro:IPR040466|mint:Q8N5F7|rcsb pdb:6QDV|entrezgene/locuslink:79576(identity)|refseq:NM_024528.3(identity)	refseq:NP_001119532.2|refseq:NP_001158229.1|refseq:NP_055512.1|ensembl:ENSG00000198929(gene)|ensembl:ENST00000361897(transcript)|go:"GO:0003062"(regulation of heart rate by chemical signal)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903762"(positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:2000170"(positive regulation of peptidyl-cysteine S-nitrosylation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|entrezgene/locuslink:9722(identity)|refseq:NM_014697.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:AiSgP+Qr12IZX1LBTsna82wmkks9606	rogid:bpv0yuTlHR7wYE9SJ4krek2gJXQ9606	intact-crc:F732E9316F78CBEF|rigid:DP6Qaop70Sck2Wo7WJ1dNDLhZdo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N488	uniprotkb:P46108-2	intact:EBI-752324|uniprotkb:Q9P2W5|uniprotkb:Q9UMW4|ensembl:ENSP00000419494	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:rybp_human(display_long)|uniprotkb:Death effector domain-associated factor(gene name synonym)|uniprotkb:YY1 and E4TF1-associated factor 1(gene name synonym)|uniprotkb:Apoptin-associating protein 1(gene name synonym)|uniprotkb:RYBP(gene name)|psi-mi:RYBP(display_short)|uniprotkb:DEDAF(gene name synonym)|uniprotkb:YEAF1(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699115|imex:IM-22632-528	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036366.3|dip:DIP-41435N|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR033774|interpro:IPR036443|interpro:IPR039958|mint:Q8N488|rcsb pdb:3IXS|reactome:R-HSA-8939243|reactome:R-HSA-8953750|ensembl:ENSG00000163602(gene)|ensembl:ENST00000477973(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|entrezgene/locuslink:23429(identity)|refseq:NM_012234.6(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:t9ef8aO/5xEAB3hMlElJCktEIOU9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:B189FB04BB80EA64|rigid:L9geWtSz0jzIBlVSDCoBOeDfro4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q8N488	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-752324|uniprotkb:Q9P2W5|uniprotkb:Q9UMW4|ensembl:ENSP00000419494	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:rybp_human(display_long)|uniprotkb:Death effector domain-associated factor(gene name synonym)|uniprotkb:YY1 and E4TF1-associated factor 1(gene name synonym)|uniprotkb:Apoptin-associating protein 1(gene name synonym)|uniprotkb:RYBP(gene name)|psi-mi:RYBP(display_short)|uniprotkb:DEDAF(gene name synonym)|uniprotkb:YEAF1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699125|imex:IM-22632-529	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_036366.3|dip:DIP-41435N|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR033774|interpro:IPR036443|interpro:IPR039958|mint:Q8N488|rcsb pdb:3IXS|reactome:R-HSA-8939243|reactome:R-HSA-8953750|ensembl:ENSG00000163602(gene)|ensembl:ENST00000477973(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|entrezgene/locuslink:23429(identity)|refseq:NM_012234.6(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:t9ef8aO/5xEAB3hMlElJCktEIOU9606	intact-crc:D2205D2434B8C8AF|rigid:/XOoham/v6lZtoHAA1uygvjoZNM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:Q8N488	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-752324|uniprotkb:Q9P2W5|uniprotkb:Q9UMW4|ensembl:ENSP00000419494	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:rybp_human(display_long)|uniprotkb:Death effector domain-associated factor(gene name synonym)|uniprotkb:YY1 and E4TF1-associated factor 1(gene name synonym)|uniprotkb:Apoptin-associating protein 1(gene name synonym)|uniprotkb:RYBP(gene name)|psi-mi:RYBP(display_short)|uniprotkb:DEDAF(gene name synonym)|uniprotkb:YEAF1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699135|imex:IM-22632-530	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	refseq:NP_036366.3|dip:DIP-41435N|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR033774|interpro:IPR036443|interpro:IPR039958|mint:Q8N488|rcsb pdb:3IXS|reactome:R-HSA-8939243|reactome:R-HSA-8953750|ensembl:ENSG00000163602(gene)|ensembl:ENST00000477973(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|entrezgene/locuslink:23429(identity)|refseq:NM_012234.6(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:t9ef8aO/5xEAB3hMlElJCktEIOU9606	intact-crc:C1514098E6E8559D|rigid:uZ3mnBprx/+WiB+LeHuJqOpLPxY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N3J3	uniprotkb:Q92569	intact:EBI-8465499|intact:EBI-11143578|uniprotkb:Q9HAI1|uniprotkb:A8K7A9|intact:MINT-8417621|uniprotkb:Q9BWM9|ensembl:ENSP00000313500	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:hrob_human(display_long)|uniprotkb:HROB(gene name)|psi-mi:HROB(display_short)|uniprotkb:C17orf53(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699165|imex:IM-22632-533	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001308239.1|refseq:NP_001308240.1|refseq:NP_076937.2|refseq:NP_001164722.1|ensembl:ENSG00000125319(gene)|ensembl:ENST00000319977(transcript)|go:"GO:0000725"(recombinational repair)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007292"(female gamete generation)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0048232"(male gamete generation)|go:"GO:0090734"(site of DNA damage)|interpro:IPR028045|mint:Q8N3J3|refseq:XM_006722075.1(identity)|entrezgene/locuslink:78995(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	comment:mint|comment:homomint	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:17UG6ibrpmmgbZ6ad7bKXmc2z3A9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:FAA066177E8438EB|rigid:0ccAib2rSXHDq0zIsu36cs4zPlk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TEW6	uniprotkb:Q8N485	intact:EBI-6918542|ensembl:ENSP00000344277|ensembl:ENSP00000455128|uniprotkb:O75209|uniprotkb:Q9BTP2|uniprotkb:Q9NVV3	intact:EBI-10694501|uniprotkb:Q8N7I2|uniprotkb:A8K4R9|ensembl:ENSP00000274382	psi-mi:dok4_human(display_long)|uniprotkb:DOK4(gene name)|psi-mi:DOK4(display_short)|uniprotkb:Downstream of tyrosine kinase 4(gene name synonym)|uniprotkb:Insulin receptor substrate 5(gene name synonym)	psi-mi:lix1_human(display_long)|uniprotkb:LIX1(gene name)|psi-mi:LIX1(display_short)|uniprotkb:C5orf11(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699145|imex:IM-22632-531	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000125170(gene)|ensembl:ENST00000340099(transcript)|ensembl:ENST00000569548(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0043410"(positive regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_060580.2|refseq:XP_005256100.1|entrezgene/locuslink:55715(identity)|refseq:NM_018110.3(identity)	refseq:NP_694966.3|ensembl:ENSG00000145721(gene)|ensembl:ENST00000274382(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR029270|refseq:NM_153234.4(identity)|entrezgene/locuslink:167410(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Xc4aPsHtdQKj02Q5cqqgw29pSS09606	rogid:l+3u4U0RlFJKO3tqAsJ0fLKqzoo9606	intact-crc:79F335ECBB888B36|rigid:QCjhpn0koevcXCo8ir11jvBv9as	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49757-3	uniprotkb:Q8N448	intact:EBI-10692196|ensembl:ENSP00000352563|ensembl:ENSP00000451117	intact:EBI-2340947|uniprotkb:Q6ZMH2|uniprotkb:Q5W0P0|uniprotkb:Q96SH4|ensembl:ENSP00000325929|ensembl:ENSP00000497224	psi-mi:p49757-3(display_long)|uniprotkb:C14orf41(gene name synonym)|uniprotkb:NUMB(gene name)|psi-mi:NUMB(display_short)|uniprotkb:Protein S171(gene name synonym)|uniprotkb:p71(isoform synonym)	psi-mi:lnx2_human(display_long)|uniprotkb:LNX2(gene name)|psi-mi:LNX2(display_short)|uniprotkb:PDZRN1(gene name synonym)|uniprotkb:Numb-binding protein 2(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699155|imex:IM-22632-532	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-915016(isoform-parent)|uniprotkb:P49757-3(isoform-parent)|ensembl:ENSG00000133961(gene)|ensembl:ENST00000359560(transcript)|ensembl:ENST00000557597(transcript)|entrezgene/locuslink:8650(identity)|refseq:NM_001005745.1(identity)	refseq:NP_699202.1|refseq:XP_016875923.1|ensembl:ENSG00000139517(gene)|ensembl:ENST00000316334(transcript)|ensembl:ENST00000649248(transcript)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8N448|rcsb pdb:2VWR|rcsb pdb:5DIN|rcsb pdb:5E11|rcsb pdb:5E1Y|rcsb pdb:5E21|rcsb pdb:5E22|entrezgene/locuslink:222484(identity)|refseq:NM_153371.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:N2YwdjNBMiXeMFYxQrJDxqeNkSA9606	rogid:cIS5t4XkbnIgelDlUc692nI285g9606	intact-crc:A973806745A8AD97|rigid:mHf4ulriWv9OfyzxJLX7Zx1WVqs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZS5	uniprotkb:P40763	intact:EBI-8477661|intact:MINT-8417707|uniprotkb:Q8IZS3|uniprotkb:Q8IZR9|uniprotkb:Q7Z2X5|uniprotkb:Q8IUL6|uniprotkb:Q8IZS1|uniprotkb:Q8IUM1	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:ofcc1_human(display_long)|uniprotkb:OFCC1(gene name)|psi-mi:OFCC1(display_short)|uniprotkb:MRDS1(gene name synonym)|uniprotkb:Orofacial clefting chromosomal breakpoint region candidate 1 protein(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699175|imex:IM-22632-534	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR031390|mint:Q8IZS5|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:XM_003118558.3(identity)|entrezgene/locuslink:266553(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	comment:mint|comment:homomint	crc64:6C00632211C8012D	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:4cDMDdOlk+3FSJ96g5F+dQ5dIJw9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:F64DCEC43FC3769A|rigid:Rb+EOsKpdPXrqnFb88B6ICJ+JI0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IXL7-2	uniprotkb:Q13387	intact:EBI-10699187|ensembl:ENSP00000312274|ensembl:ENSP00000441650|ensembl:ENSP00000481483|ensembl:ENSP00000494265|ensembl:ENSP00000494941|ensembl:ENSP00000496008	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:q8ixl7-2(display_long)|uniprotkb:UNQ1965/PRO4487(orf name)|uniprotkb:B(isoform synonym)|uniprotkb:C(isoform synonym)|uniprotkb:D(isoform synonym)|uniprotkb:MSRB3(gene name)|psi-mi:MSRB3(display_short)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699185|imex:IM-22632-535	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000174099(gene)|ensembl:ENST00000308259(transcript)|ensembl:ENST00000535664(transcript)|ensembl:ENST00000614640(transcript)|ensembl:ENST00000642404(transcript)|ensembl:ENST00000642411(transcript)|ensembl:ENST00000646299(transcript)|uniprotkb:Q8IXL7-2(isoform-parent)|intact:EBI-8634060(isoform-parent)|entrezgene/locuslink:253827(identity)|refseq:NM_001193461.1(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	isoform-comment:Has a transit peptide.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:wX81ztt8xDjlCCGHE6zYOGZ+69Y9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:53779B1A9FB17931|rigid:dAOi8JzCRtbAPHnAdBjpqCuf24g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IUI8	uniprotkb:Q8NEU8	intact:EBI-2872414|ensembl:ENSP00000318804|uniprotkb:Q2MLY7|uniprotkb:A6NJF3|uniprotkb:B2R8C3|uniprotkb:Q9Y6M8|uniprotkb:Q9UNI3	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	psi-mi:crlf3_human(display_long)|uniprotkb:CRLF3(gene name)|psi-mi:CRLF3(display_short)|uniprotkb:CRLM9(gene name synonym)|uniprotkb:CREME9(gene name synonym)|uniprotkb:CYTOR4(gene name synonym)|uniprotkb:P48(gene name synonym)|uniprotkb:Cytokine receptor-like molecule 9(gene name synonym)|uniprotkb:Cytokine receptor-related protein 4(gene name synonym)|uniprotkb:Type I cytokine receptor-like factor p48(gene name synonym)	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699199|imex:IM-22632-536	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000176390(gene)|ensembl:ENST00000324238(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8IUI8|refseq:NP_057070.3|entrezgene/locuslink:51379(identity)|refseq:NM_015986.3(identity)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:iUxgX/ff546WqMhszXxotEhEZ3c9606	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	intact-crc:AE96572AE5F04BAC|rigid:4jIPNHHvTKxYec+ULvRHQWXlWG0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q86X59	uniprotkb:Q8NEU8	intact:EBI-8465536|intact:MINT-8417623|intact:EBI-28972298	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	psi-mi:cq082_human(display_long)|uniprotkb:LINC02875(gene name)|psi-mi:LINC02875(display_short)|uniprotkb:C17orf82(gene name synonym)	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699209|imex:IM-22632-537	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_982249.2|mint:Q86X59|refseq:NM_203425.1(identity)|entrezgene/locuslink:388407(identity)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	-	comment:mint|comment:homomint	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:YbKfsONQu1hM5WKmhZuiazw0WaI9606	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	intact-crc:09207B793B34E877|rigid:Cw1lTmcgeqs05qGlRgVVOblpraw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q86X59	uniprotkb:Q9NP31	intact:EBI-8465536|intact:MINT-8417623|intact:EBI-28972298	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:cq082_human(display_long)|uniprotkb:LINC02875(gene name)|psi-mi:LINC02875(display_short)|uniprotkb:C17orf82(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699219|imex:IM-22632-538	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_982249.2|mint:Q86X59|refseq:NM_203425.1(identity)|entrezgene/locuslink:388407(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	comment:mint|comment:homomint	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:YbKfsONQu1hM5WKmhZuiazw0WaI9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:0B8A9A5BA4A684FB|rigid:HIQpZPwTXEVQrEdzNBSoddhSwnc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7L591-3	uniprotkb:Q8NEU8	intact:EBI-10694655|ensembl:ENSP00000325174	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699253|imex:IM-22632-541	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	intact-crc:D2DECB29F6364403|rigid:hxLq9Q0vR6/VbXi7bkAMPcJqEdU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TB24	uniprotkb:Q7Z6I5	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	intact:EBI-10696971|uniprotkb:B2RMW1|uniprotkb:A0AVA8|ensembl:ENSP00000335392	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:spt12_human(display_long)|uniprotkb:SPATA12(gene name)|psi-mi:SPATA12(display_short)|uniprotkb:SRG5(gene name synonym)|uniprotkb:Spermatogenesis-related protein 5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699229|imex:IM-22632-539	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	refseq:NP_859078.1|refseq:XP_011531978.1|ensembl:ENSG00000186451(gene)|ensembl:ENST00000334325(transcript)|entrezgene/locuslink:353324(identity)|refseq:NM_181727.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	rogid:wclT+6HU+T7AK3KNk+1VbkI+v389606	intact-crc:C6347EC3FC4ED521|rigid:wxh1BIdvdmcTnZ+NehfnBmzhi1k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z6G8-8	uniprotkb:Q13671	intact:EBI-10699239|ensembl:ENSP00000447312	intact:EBI-366017|uniprotkb:O15010|uniprotkb:Q00427|uniprotkb:Q96CC8|ensembl:ENSP00000310406	psi-mi:q7z6g8-8(display_long)|uniprotkb:Amyloid-beta protein intracellular domain-associated protein 1(gene name synonym)|uniprotkb:E2A-PBX1-associated protein(gene name synonym)|uniprotkb:ANKS1B(gene name)|psi-mi:ANKS1B(display_short)	psi-mi:rin1_human(display_long)|uniprotkb:RIN1(gene name)|psi-mi:RIN1(display_short)|uniprotkb:Ras interaction/interference protein 1(gene name synonym)|uniprotkb:Ras inhibitor JC99(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699243|imex:IM-22632-540	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7876312(isoform-parent)|ensembl:ENSG00000185046(gene)|ensembl:ENST00000549025(transcript)|entrezgene/locuslink:56899(identity)|refseq:NM_001204066.1(identity)	ensembl:ENSG00000174791(gene)|ensembl:ENST00000311320(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR036860|interpro:IPR037191|reactome:R-HSA-8876198|refseq:NP_004283.2|dip:DIP-117N|refseq:NM_004292.2(identity)|entrezgene/locuslink:9610(identity)	-	isoform-comment:"Ref.6 (AAH68451) sequence is in conflict in position: 325:P->R."	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Etjl020SQEbiyfHB/qKnKoe03OI9606	rogid:oj/ZbyM0Oqe0wDMlFbJHCtGzMwA9606	intact-crc:2567F713F3BB8EDE|rigid:1kTIvWRYSBqN1UTZYorKT3ZuBTQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TB24	uniprotkb:Q7L591-3	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	intact:EBI-10694655|ensembl:ENSP00000325174	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699263|imex:IM-22632-542	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	-	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	intact-crc:3E23A4AC2DB0A8B5|rigid:hbtWR8a8DhPzUe5E4kgNGV5+Cqg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6XD76	uniprotkb:P46108-2	intact:EBI-10254793|uniprotkb:Q7RTS2|ensembl:ENSP00000345420	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:ascl4_human(display_long)|uniprotkb:ASCL4(gene name)|psi-mi:ASCL4(display_short)|uniprotkb:Achaete-scute-like protein 4(gene name synonym)|uniprotkb:BHLHA44(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 44(gene name synonym)|uniprotkb:HASH4(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699273|imex:IM-22632-543	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_982260.2|ensembl:ENSG00000187855(gene)|ensembl:ENST00000342331(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043588"(skin development)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015660(Achaete-scute transcription factor related)|interpro:IPR036638|entrezgene/locuslink:121549(identity)|refseq:NM_203436.2(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rnvreQ1yUmnMJkPwdQLRcS2F6kM9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:C0A5B3461E56FBBB|rigid:s0MNZWP/WRseOVhqlIDgcGGruUw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6QEF8-4	uniprotkb:P46108	intact:EBI-10699285	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:q6qef8-4(display_long)|uniprotkb:CORO6(gene name)|psi-mi:CORO6(display_short)|uniprotkb:Coronin-like protein E(gene name synonym)|uniprotkb:PP1009(orf name)|uniprotkb:PP1782(orf name)|uniprotkb:PP1881(orf name)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699283|imex:IM-22632-544	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-10254194(isoform-parent)|uniprotkb:Q6QEF8-4(isoform-parent)|refseq:XM_005258056.2(identity)|entrezgene/locuslink:84940(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:2J4pnJSi7fhaoIJKeVc+ACT01ag9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:E7DA8C28F18DB49C|rigid:sMXblW46SHBvx0ujlKCnSDJ2uGc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60880	uniprotkb:Q6P1Q0	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-1549822|uniprotkb:B3KXK7|uniprotkb:A6NER7|uniprotkb:Q6X2E4|uniprotkb:Q6X2E5|uniprotkb:Q7L2G9|uniprotkb:Q7L690|uniprotkb:Q8WXW6|uniprotkb:Q96PK7|uniprotkb:Q9Y3X3|uniprotkb:Q9BY59|intact:EBI-10972516|ensembl:ENSP00000262055	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:ltmd1_human(display_long)|uniprotkb:LETMD1(gene name)|psi-mi:LETMD1(display_short)|uniprotkb:Cervical cancer 1 proto-oncogene protein p40(gene name synonym)|uniprotkb:Cervical cancer proto-oncogene 2 protein(gene name synonym)|uniprotkb:HCRR-2(gene name synonym)|uniprotkb:HCCR-1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699297|imex:IM-22632-545	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N|entrezgene/locuslink:4068(identity)|refseq:NM_002351.4(identity)	refseq:NP_056231.3|refseq:XP_006719402.1|refseq:XP_006719403.1|refseq:NP_001230618.1|ensembl:ENSG00000050426(gene)|ensembl:ENST00000262055(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043022"(ribosome binding)|interpro:IPR011685(LETM1-like)|interpro:IPR033122|interpro:IPR044202|mint:Q6P1Q0|entrezgene/locuslink:25875(identity)|refseq:NM_015416.4(identity)	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:iyp46kHqB7mu8W0BYCn64BDkVVU9606	intact-crc:DC5B253BC25361CA|rigid:AqTVLGs33OXauh89S/xhVfO2pxQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TB24	uniprotkb:Q6P1J6-2	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	intact:EBI-10694821	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:q6p1j6-2(display_long)|uniprotkb:PLB1(gene name)|psi-mi:PLB1(display_short)|uniprotkb:PLB(gene name synonym)|uniprotkb:Phospholipase B/lipase(gene name synonym)|uniprotkb:Lysophospholipase(gene name synonym)|uniprotkb:Phospholipase A2(gene name synonym)|uniprotkb:Triacylglycerol lipase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699317|imex:IM-22632-547	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	intact:EBI-10757275(isoform-parent)|uniprotkb:Q6P1J6-2(isoform-parent)|refseq:NM_153021.4(identity)|entrezgene/locuslink:151056(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	rogid:WLweRT1dlb70eDlX6qsoWBzXA6c9606	intact-crc:EFA0FF6BF4533410|rigid:SkA6K+E8n8I8zep+Dl9WCqDFdwg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6P1Q0	uniprotkb:P08631-2	intact:EBI-1549822|uniprotkb:B3KXK7|uniprotkb:A6NER7|uniprotkb:Q6X2E4|uniprotkb:Q6X2E5|uniprotkb:Q7L2G9|uniprotkb:Q7L690|uniprotkb:Q8WXW6|uniprotkb:Q96PK7|uniprotkb:Q9Y3X3|uniprotkb:Q9BY59|intact:EBI-10972516|ensembl:ENSP00000262055	intact:EBI-9834454|ensembl:ENSP00000429848|ensembl:ENSP00000486627	psi-mi:ltmd1_human(display_long)|uniprotkb:LETMD1(gene name)|psi-mi:LETMD1(display_short)|uniprotkb:Cervical cancer 1 proto-oncogene protein p40(gene name synonym)|uniprotkb:Cervical cancer proto-oncogene 2 protein(gene name synonym)|uniprotkb:HCRR-2(gene name synonym)|uniprotkb:HCCR-1(gene name synonym)	psi-mi:p08631-2(display_long)|uniprotkb:p59-HCK(isoform synonym)|uniprotkb:p59Hck(isoform synonym)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699307|imex:IM-22632-546	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056231.3|refseq:XP_006719402.1|refseq:XP_006719403.1|refseq:NP_001230618.1|ensembl:ENSG00000050426(gene)|ensembl:ENST00000262055(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043022"(ribosome binding)|interpro:IPR011685(LETM1-like)|interpro:IPR033122|interpro:IPR044202|mint:Q6P1Q0|entrezgene/locuslink:25875(identity)|refseq:NM_015416.4(identity)	uniprotkb:P08631-2(isoform-parent)|intact:EBI-346340(isoform-parent)|ensembl:ENSG00000101336(gene)|ensembl:ENST00000520553(transcript)|ensembl:ENST00000629881(transcript)|entrezgene/locuslink:3055(identity)|refseq:NM_001172129.1(identity)	-	-	isoform-comment:Initiator Met-1 is removed. Contains a N-myristoyl glycine at position 2. Contains a S-palmitoyl cysteine at position 3.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:iyp46kHqB7mu8W0BYCn64BDkVVU9606	rogid:qSgfntp+jqdyi7qsc7u7UA7ylO09606	intact-crc:AA245ECCF9ED7315|rigid:aro8Jyx/pUPI+9C665vZZSVpkho	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6NSH3	uniprotkb:O75052	intact:EBI-8635816|uniprotkb:A8K842|uniprotkb:B7ZMC5|intact:MINT-8162469	intact:EBI-780467|uniprotkb:B7ZLF5|uniprotkb:Q3T551|uniprotkb:O43564|uniprotkb:Q5VU95|ensembl:ENSP00000355133	psi-mi:ct455_human(display_long)|uniprotkb:CT45A5(gene name)|psi-mi:CT45A5(display_short)|uniprotkb:CT45-5(gene name synonym)|uniprotkb:Cancer/testis antigen 45-5(gene name synonym)|uniprotkb:Cancer/testis antigen 45A5(gene name synonym)	psi-mi:capon_human(display_long)|uniprotkb:C-terminal PDZ ligand of neuronal nitric oxide synthase protein(gene name synonym)|uniprotkb:Nitric oxide synthase 1 adaptor protein(gene name synonym)|uniprotkb:NOS1AP(gene name)|psi-mi:NOS1AP(display_short)|uniprotkb:CAPON(gene name synonym)|uniprotkb:KIAA0464(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699327|imex:IM-22632-548	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR029307|refseq:NP_001278456.1|refseq:NP_001278457.1|refseq:NP_001278458.1|refseq:NP_001278459.1|refseq:NM_001291529.1(identity)|entrezgene/locuslink:441521(identity)	refseq:NP_001119532.2|refseq:NP_001158229.1|refseq:NP_055512.1|ensembl:ENSG00000198929(gene)|ensembl:ENST00000361897(transcript)|go:"GO:0003062"(regulation of heart rate by chemical signal)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903762"(positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:2000170"(positive regulation of peptidyl-cysteine S-nitrosylation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NM_014697.2(identity)|entrezgene/locuslink:9722(identity)	-	comment:mint	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:GN6dUbrSM2U+27QojBcGat4pxZU9606	rogid:bpv0yuTlHR7wYE9SJ4krek2gJXQ9606	intact-crc:4ADCE38EB3AF946C|rigid:Q3mDeLAKBJG7dwNZibG5AZtjTx8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6N069-4	uniprotkb:Q9NP31	intact:EBI-10699337|ensembl:ENSP00000386103	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:q6n069-4(display_long)|uniprotkb:NAA16(gene name)|psi-mi:NAA16(display_short)|uniprotkb:NARG1L(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:NMDA receptor-regulated 1-like protein(gene name synonym)|uniprotkb:Short(isoform synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699341|imex:IM-22632-549	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000172766(gene)|ensembl:ENST00000403412(transcript)|intact:EBI-2561139(isoform-parent)|uniprotkb:Q6N069-4(isoform-parent)|entrezgene/locuslink:79612(identity)|refseq:NM_001110798.1(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:LUVVFnoWijVuhiZ6ggsMT3SLYx49606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:B26EC488D4C0031A|rigid:p/KX973LIkpvdIb+9NZA4bL/YrA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q5TAQ9	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-740686|uniprotkb:Q12839|uniprotkb:Q4QQI6|uniprotkb:Q53F14|uniprotkb:Q66K50|uniprotkb:Q68CS7|uniprotkb:Q96E00|intact:EBI-2559125|uniprotkb:D3DVE6|ensembl:ENSP00000318227|ensembl:ENSP00000357052|ensembl:ENSP00000357053	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:dcaf8_human(display_long)|uniprotkb:DCAF8(gene name)|psi-mi:DCAF8(display_short)|uniprotkb:H326(gene name synonym)|uniprotkb:WDR42A(gene name synonym)|uniprotkb:WD repeat-containing protein 42A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699361|imex:IM-22632-551	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_056541.2|ensembl:ENSG00000132716(gene)|ensembl:ENST00000326837(transcript)|ensembl:ENST00000368073(transcript)|ensembl:ENST00000368074(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:Q5TAQ9|rcsb pdb:3I8E|reactome:R-HSA-8951664|dip:DIP-48762N|refseq:NM_015726.3(identity)|entrezgene/locuslink:50717(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:6Bbv6KwtHrJ0W4mcIronVPj4bTA9606	intact-crc:512ECA6434068769|rigid:CSuclivl5D7i7BlJL5oz9LAaCzM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q68G74	uniprotkb:P46108	intact:EBI-8474075|intact:MINT-8417689|uniprotkb:E9PGE3|ensembl:ENSP00000294638	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:lhx8_human(display_long)|uniprotkb:LHX8(gene name)|psi-mi:LHX8(display_short)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699351|imex:IM-22632-550	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001243043.1|refseq:NP_001001933.1|ensembl:ENSG00000162624(gene)|ensembl:ENST00000294638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001674"(female germ cell nucleus)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007611"(learning or memory)|go:"GO:0008585"(female gonad development)|go:"GO:0021884"(forebrain neuron development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q68G74|entrezgene/locuslink:431707(identity)|refseq:NM_001001933.1(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	comment:mint|comment:homomint	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:L7W2mSN0r9Fl/94L/D2dL5mGHz89606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:2D82041FDB952E2E|rigid:QtTjSMcLV9o5o92dCIA3zOBg4uo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75052	uniprotkb:Q5T1N1	intact:EBI-780467|uniprotkb:B7ZLF5|uniprotkb:Q3T551|uniprotkb:O43564|uniprotkb:Q5VU95|ensembl:ENSP00000355133	intact:EBI-10699373|uniprotkb:Q5T1N0|uniprotkb:Q8N990|uniprotkb:B9EK62|uniprotkb:Q8NCN9|ensembl:ENSP00000359018	psi-mi:capon_human(display_long)|uniprotkb:C-terminal PDZ ligand of neuronal nitric oxide synthase protein(gene name synonym)|uniprotkb:Nitric oxide synthase 1 adaptor protein(gene name synonym)|uniprotkb:NOS1AP(gene name)|psi-mi:NOS1AP(display_short)|uniprotkb:CAPON(gene name synonym)|uniprotkb:KIAA0464(gene name synonym)	psi-mi:aknd1_human(display_long)|uniprotkb:AKNAD1(gene name)|psi-mi:AKNAD1(display_short)|uniprotkb:C1orf62(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699371|imex:IM-22632-552	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119532.2|refseq:NP_001158229.1|refseq:NP_055512.1|ensembl:ENSG00000198929(gene)|ensembl:ENST00000361897(transcript)|go:"GO:0003062"(regulation of heart rate by chemical signal)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903762"(positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:2000170"(positive regulation of peptidyl-cysteine S-nitrosylation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|entrezgene/locuslink:9722(identity)|refseq:NM_014697.2(identity)	refseq:NP_689976.2|ensembl:ENSG00000162641(gene)|ensembl:ENST00000370001(transcript)|interpro:IPR022150|refseq:NM_152763.4(identity)|entrezgene/locuslink:254268(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:bpv0yuTlHR7wYE9SJ4krek2gJXQ9606	rogid:z0j7whZHg+mqzjmtOqe046ZAeDI9606	intact-crc:47137EB743705B71|rigid:qdsmpyOkllz2Cr4cWHnjcwM6Wh4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:Q5R372-9	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-10699389|ensembl:ENSP00000432490|ensembl:ENSP00000434600	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:q5r372-9(display_long)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:HHL(gene name synonym)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699393|imex:IM-22632-553	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000478442(transcript)|ensembl:ENST00000486220(transcript)|intact:EBI-2810417(isoform-parent)|uniprotkb:Q5R372-9(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:NM_001243763.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:83hc7YeudqbgTfdlWYKvKpDermU9606	intact-crc:63F056B093830E43|rigid:URLgQz/TcbgOn4eak6Ed0/gmZMA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5JSZ5	uniprotkb:P46108	intact:EBI-744891|uniprotkb:Q66VZ2|uniprotkb:Q9H683|uniprotkb:Q5JSZ7|uniprotkb:O60270|intact:EBI-2512629|intact:EBI-947989|uniprotkb:Q68CR0|intact:EBI-2559356|uniprotkb:Q96EI9|ensembl:ENSP00000508005|ensembl:ENSP00000508048	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:prc2b_human(display_long)|uniprotkb:PRRC2B(gene name)|psi-mi:PRRC2B(display_short)|uniprotkb:HLA-B-associated transcript 2-like 1(gene name synonym)|uniprotkb:KIAA0515(gene name synonym)|uniprotkb:BAT2L(gene name synonym)|uniprotkb:BAT2L1(gene name synonym)|uniprotkb:Proline-rich coiled-coil protein 2B(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699413|imex:IM-22632-555	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037450.2|ensembl:ENST00000682501|ensembl:ENSP00000508073|ensembl:ENSP00000508048|ensembl:ENSP00000508005|ensembl:ENSG00000288701(gene)|ensembl:ENST00000683519(transcript)|ensembl:ENST00000684596(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0030154"(cell differentiation)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q5JSZ5|entrezgene/locuslink:84726(identity)|refseq:NM_013318.3(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:N1MgJl3k+WJTF+XUf5VFIB06B909606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:C9B12B5690CD60E9|rigid:8sa+uEwl55AVJdDlT0Ktep58Tto	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5JVL4	uniprotkb:Q18PE1	intact:EBI-743105|ensembl:ENSP00000360107|uniprotkb:Q5XKM4|uniprotkb:Q6E1U7|uniprotkb:Q6E1U8|uniprotkb:Q8WUL2|uniprotkb:Q9NVW6|intact:EBI-11099619|uniprotkb:B4DMU3|uniprotkb:F5GZD8	intact:EBI-3046647|ensembl:ENSP00000344432|uniprotkb:E9PB56|uniprotkb:Q8NBC1|uniprotkb:Q86XG5|uniprotkb:Q8N2J3|uniprotkb:A2A499|uniprotkb:Q6P6A6|uniprotkb:A2RRD4	psi-mi:efhc1_human(display_long)|uniprotkb:EFHC1(gene name)|psi-mi:EFHC1(display_short)|uniprotkb:Myoclonin-1(gene name synonym)	psi-mi:dok7_human(display_long)|uniprotkb:DOK7(gene name)|psi-mi:DOK7(display_short)|uniprotkb:C4orf25(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 7(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699403|imex:IM-22632-554	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000371068(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051302"(regulation of cell division)|go:"GO:0060285"(cilium-dependent cell motility)|go:"GO:0072686"(mitotic spindle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006602(Region of unknown function DM10)|interpro:IPR011992(EF-Hand type)|interpro:IPR040193|mint:Q5JVL4|refseq:NP_001165891.1|refseq:NP_060570.2|ensembl:ENSG00000096093(gene)|entrezgene/locuslink:114327(identity)|refseq:NM_018100.3(identity)	ensembl:ENSG00000175920(gene)|ensembl:ENST00000340083(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045202"(synapse)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037746|interpro:IPR037747|interpro:IPR037748|refseq:NP_001288000.1|refseq:NP_001158145.1|refseq:NP_775931.3|refseq:NP_001243825.1|refseq:NM_173660.4(identity)|entrezgene/locuslink:285489(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:l5I5K4Lgihe08j5BuPBk4uDY+qk9606	rogid:RNSUGsyQVitqfrm+mTmzf0fZHR49606	intact-crc:D7777AAC4A748719|rigid:n2xV6rO9P0p0/Gv2qj7DYIf6SG0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q5H9K5	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-2818620|uniprotkb:Q8NDS3|uniprotkb:Q96JN6|ensembl:ENSP00000361868|ensembl:ENSP00000437529	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:zmat1_human(display_long)|uniprotkb:ZMAT1(gene name)|psi-mi:ZMAT1(display_short)|uniprotkb:KIAA1789(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699423|imex:IM-22632-556	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	ensembl:ENSG00000166432(gene)|ensembl:ENST00000372782(transcript)|ensembl:ENST00000540921(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|refseq:NP_001269329.1|refseq:NP_001269330.1|refseq:XP_006724774.1|refseq:XP_016885393.1|entrezgene/locuslink:84460(identity)|refseq:NM_001011657.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:hN4WqKioK0ZoOheB8rdh/4RaDX89606	intact-crc:FC12400866BBBF9D|rigid:eMvEYSThgsXQ+pkWs5WMCfnhqYA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q53FE4	uniprotkb:P46108-2	intact:EBI-715110|uniprotkb:Q6FI84|uniprotkb:Q6IS77|uniprotkb:Q9H0D9|uniprotkb:Q8NA78|ensembl:ENSP00000322582	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:cd017_human(display_long)|uniprotkb:C4orf17(gene name)|psi-mi:C4orf17(display_short)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699443|imex:IM-22632-558	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115525.2|ensembl:ENSG00000138813(gene)|ensembl:ENST00000326581(transcript)|interpro:IPR037394|mint:Q53FE4|entrezgene/locuslink:84103(identity)|refseq:NM_032149.2(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:2FN9Qv/iZJQqZPeOx8hqswAd5cA9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:572FA58DDAEB57BC|rigid:2Hc+C0skk1DtFlfjYI4/xK578lY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5H9K5	uniprotkb:Q92569	intact:EBI-2818620|uniprotkb:Q8NDS3|uniprotkb:Q96JN6|ensembl:ENSP00000361868|ensembl:ENSP00000437529	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:zmat1_human(display_long)|uniprotkb:ZMAT1(gene name)|psi-mi:ZMAT1(display_short)|uniprotkb:KIAA1789(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699433|imex:IM-22632-557	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166432(gene)|ensembl:ENST00000372782(transcript)|ensembl:ENST00000540921(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|refseq:NP_001269329.1|refseq:NP_001269330.1|refseq:XP_006724774.1|refseq:XP_016885393.1|entrezgene/locuslink:84460(identity)|refseq:NM_001011657.3(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:hN4WqKioK0ZoOheB8rdh/4RaDX89606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:9F695C34B49A9F4D|rigid:UvCJnBoOtKoQGcPNLZ+ml6H5Kk0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q2M385	uniprotkb:Q8TB24	intact:EBI-2826504|uniprotkb:Q2M1T6|uniprotkb:Q8TEF8|ensembl:ENSP00000354335	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	psi-mi:mpeg1_human(display_long)|uniprotkb:Perforin-2(gene name synonym)|uniprotkb:MPEG1(gene name)|psi-mi:MPEG1(display_short)	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699453|imex:IM-22632-559	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034485.1|ensembl:ENSG00000197629(gene)|ensembl:ENST00000361050(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR020864|interpro:IPR039707|rcsb pdb:6U23|rcsb pdb:6U2J|rcsb pdb:6U2K|rcsb pdb:6U2L|rcsb pdb:6U2W|refseq:NM_001039396.1(identity)|entrezgene/locuslink:219972(identity)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:dMq3zTZSMVp5/r562gvoFXWGZMk9606	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	intact-crc:93E0913729E1BA09|rigid:RP1nVQOaa9urDtlPFPgA9+qPj7c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TB24	uniprotkb:Q17RB0	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	intact:EBI-10238588|ensembl:ENSP00000375268	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:rtl8b_human(display_long)|uniprotkb:RTL8B(gene name)|psi-mi:RTL8B(display_short)|uniprotkb:CXX1C(gene name synonym)|uniprotkb:FAM127C(gene name synonym)|uniprotkb:MAR8B(gene name synonym)|uniprotkb:Mammalian retrotransposon derived protein 8B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699463|imex:IM-22632-560	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	refseq:NP_001071641.1|ensembl:ENSG00000212747(gene)|ensembl:ENST00000391440(transcript)|go:"GO:0005730"(nucleolus)|interpro:IPR032549|interpro:IPR032567|refseq:NM_001078173.1(identity)|entrezgene/locuslink:441518(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	rogid:158r8mlbMJpSaQ7UyJ7Kiov4QXU9606	intact-crc:FD2134E1B4D89BFE|rigid:hYG39sbAtQAzNr1I2khYjoVqq34	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15910-2	uniprotkb:Q8TB24	intact:EBI-10699473|ensembl:ENSP00000320147	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	psi-mi:q15910-2(display_long)|uniprotkb:EZH2(gene name)|psi-mi:EZH2(display_short)|uniprotkb:ENX-1(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:KMT6(gene name synonym)|uniprotkb:Lysine N-methyltransferase 6(gene name synonym)	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699477|imex:IM-22632-561	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000106462(gene)|ensembl:ENST00000320356(transcript)|intact:EBI-530054(isoform-parent)|uniprotkb:Q15910-2(isoform-parent)|refseq:NM_004456.4(identity)|entrezgene/locuslink:2146(identity)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:4fxQDBu9qGPMtel2lt38ULDK85o9606	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	intact-crc:F6A9A600A23711F1|rigid:Aw8i/5NYjl0uqMUIAwcMcLxVtsc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15633	uniprotkb:Q13387	intact:EBI-978581|uniprotkb:Q12878|ensembl:ENSP00000266987|uniprotkb:Q9BRY2|uniprotkb:Q8WY32|uniprotkb:Q8WY33	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:trbp2_human(display_long)|uniprotkb:Trans-activation-responsive RNA-binding protein(gene name synonym)|uniprotkb:TARBP2(gene name)|psi-mi:TARBP2(display_short)|uniprotkb:TRBP(gene name synonym)|uniprotkb:TAR RNA-binding protein 2(gene name synonym)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699487|imex:IM-22632-562	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000139546(gene)|ensembl:ENST00000266987(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0016442"(RISC complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046782"(regulation of viral transcription)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050689"(negative regulation of defense response to virus by host)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:0090065"(regulation of production of siRNA involved in RNA interference)|go:"GO:1903798"(regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR028605|interpro:IPR044469|interpro:IPR044470|interpro:IPR044471|mint:Q15633|rcsb pdb:2CPN|rcsb pdb:3ADL|rcsb pdb:3LLH|rcsb pdb:4WYQ|go:"GO:0016604"(nuclear body)|rcsb pdb:5N8L|rcsb pdb:5N8M|rcsb pdb:5ZAK|rcsb pdb:5ZAL|rcsb pdb:5ZAM|rcsb pdb:6ZBK|reactome:R-HSA-203927|reactome:R-HSA-426486|refseq:NP_004169.3|refseq:NP_599150.1|refseq:NP_599151.2|refseq:XP_005269171.1|refseq:XP_005269172.1|dip:DIP-29665N|refseq:NM_134323.1(identity)|entrezgene/locuslink:6895(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:2pOFQwyM408mDl2bYsKEb1yhFrE9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:FA161A095A85221F|rigid:7qiCp73ZteeH8a1uHVeQx729A50	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14847	uniprotkb:Q9NP31	intact:EBI-742828|uniprotkb:Q96ED2|uniprotkb:Q96IG0|ensembl:ENSP00000325240|ensembl:ENSP00000392853|uniprotkb:B4DGQ0	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:lasp1_human(display_long)|uniprotkb:Metastatic lymph node gene 50 protein(gene name synonym)|uniprotkb:LASP1(gene name)|psi-mi:LASP1(display_short)|uniprotkb:MLN50(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699517|imex:IM-22632-565	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006139.1|refseq:NP_001258537.1|ensembl:ENSG00000002834(gene)|ensembl:ENST00000318008(transcript)|ensembl:ENST00000435347(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006811"(ion transport)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|interpro:IPR000900(Nebulin 35 residue motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR035630|interpro:IPR036028|mint:Q14847|rcsb pdb:3I35|refseq:NM_006148.3(identity)|entrezgene/locuslink:3927(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Oa+FdJXeQhahYTqVrHYk6yBrUWI9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:4893F4820C9F3A55|rigid:GDXWZNvzISDuqMwizNwXxEKxYHI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15311	uniprotkb:P16885	intact:EBI-749285|uniprotkb:D3DUI0|ensembl:ENSP00000019317|ensembl:ENSP00000372924	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	psi-mi:rbp1_human(display_long)|uniprotkb:Ral-interacting protein 1(gene name synonym)|uniprotkb:76 kDa Ral-interacting protein(gene name synonym)|uniprotkb:Dinitrophenyl S-glutathione ATPase(gene name synonym)|uniprotkb:RALBP1(gene name)|psi-mi:RALBP1(display_short)|uniprotkb:RLIP1(gene name synonym)|uniprotkb:RLIP76(gene name synonym)|uniprotkb:RLIP(gene name synonym)	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699507|imex:IM-22632-564	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006779.1|ensembl:ENSG00000017797(gene)|ensembl:ENST00000019317(transcript)|ensembl:ENST00000383432(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008559"(ABC-type xenobiotic transporter activity)|go:"GO:0015431"(ABC-type glutathione S-conjugate transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055085"(transmembrane transport)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:1900753"(doxorubicin transport)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR039767|mint:Q15311|rcsb pdb:2KWH|rcsb pdb:2KWI|rcsb pdb:2MBG|rcsb pdb:6ZQT|rcsb pdb:6ZRN|reactome:R-HSA-9013148|reactome:R-HSA-9013149|refseq:NM_006788.3(identity)|entrezgene/locuslink:10928(identity)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:6u1yy+UdGWJbJ9SiItSAp+CqeVk9606	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	intact-crc:A20159A7C44E8AFF|rigid:f0ZLvzqffXy8NjOxmX9mSNinTeA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16591	uniprotkb:Q15435-3	intact:EBI-1380661|uniprotkb:B4DSQ2|uniprotkb:B2RCR4|uniprotkb:H2FLB8|ensembl:ENSP00000281092	intact:EBI-10695066|ensembl:ENSP00000385022	psi-mi:fer_human(display_long)|uniprotkb:Feline encephalitis virus-related kinase FER(gene name synonym)|uniprotkb:Fujinami poultry sarcoma/Feline sarcoma-related protein Fer(gene name synonym)|uniprotkb:FER(gene name)|psi-mi:FER(display_short)|uniprotkb:TYK3(gene name synonym)|uniprotkb:Proto-oncogene c-Fer(gene name synonym)|uniprotkb:Tyrosine kinase 3(gene name synonym)|uniprotkb:p94-Fer(gene name synonym)	psi-mi:q15435-3(display_long)|uniprotkb:PPP1R7(gene name)|psi-mi:PPP1R7(display_short)|uniprotkb:Protein phosphatase 1 regulatory subunit 22(gene name synonym)|uniprotkb:SDS22(gene name synonym)|uniprotkb:sds22beta1(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699497|imex:IM-22632-563	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005237.2|refseq:XP_016864719.1|refseq:XP_016864720.1|refseq:NP_001294957.1|refseq:NP_001294960.1|refseq:NP_001294967.1|refseq:XP_011541573.1|ensembl:ENSG00000151422(gene)|ensembl:ENST00000281092(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033007"(negative regulation of mast cell activation involved in immune response)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0036119"(response to platelet-derived growth factor)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038109"(Kit signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050904"(diapedesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR028539|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|interpro:IPR037452|mint:P16591|rcsb pdb:2KK6|rcsb pdb:6KC4|reactome:R-HSA-1433557|entrezgene/locuslink:2241(identity)|refseq:NM_005246.2(identity)	intact:EBI-1024281(isoform-parent)|ensembl:ENSG00000115685(gene)|ensembl:ENST00000406106(transcript)|uniprotkb:Q15435-3(isoform-parent)|entrezgene/locuslink:5510(identity)|refseq:NM_001282410.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:De5RYVRGihPHGxaflmxR8W9jC8M9606	rogid:cJCKB1W0OoVTBEjlLdLVL2FKsJ49606	intact-crc:80E708F1A89DCDC3|rigid:4DVcBjC/SRNo9tMifO0rrLlXA7M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14457	uniprotkb:Q06187	intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym)	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699527|imex:IM-22632-566	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1|entrezgene/locuslink:8678(identity)|refseq:NM_003766.3(identity)	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N|refseq:NM_000061.2(identity)|entrezgene/locuslink:695(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	intact-crc:ECE383E7AD2DC767|rigid:fzzD4vYXDLZS9fS3RcoyW/Nq20k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WU20	uniprotkb:Q14457	intact:EBI-1104330|uniprotkb:O43558|uniprotkb:Q7LDQ6|uniprotkb:B0LPF2|uniprotkb:B2R684|ensembl:ENSP00000381083|ensembl:ENSP00000447241|ensembl:ENSP00000450048	intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7	psi-mi:frs2_human(display_long)|uniprotkb:FRS2(gene name)|psi-mi:FRS2(display_short)|uniprotkb:Suc1-associated neurotrophic factor target 1(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT(gene name synonym)	psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699537|imex:IM-22632-567	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166225(gene)|ensembl:ENST00000397997(transcript)|ensembl:ENST00000549921(transcript)|ensembl:ENST00000550389(transcript)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001759"(organ induction)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007185"(transmembrane receptor protein tyrosine phosphatase signaling pathway)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046619"(lens placode formation involved in camera-type eye formation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:Q8WU20|rcsb pdb:1XR0|rcsb pdb:2MFQ|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-170968|reactome:R-HSA-2219530|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|refseq:NP_001036020.1|refseq:NP_006645.3|refseq:NP_001265280.1|refseq:NP_001265282.1|refseq:NP_001265283.1|refseq:NP_001265284.1|refseq:NP_001265285.1|refseq:NP_001265286.1|refseq:XP_016874206.1|refseq:XP_016874207.1|refseq:XP_016874208.1|refseq:NM_001278357.1(identity)|entrezgene/locuslink:10818(identity)	ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1|entrezgene/locuslink:8678(identity)|refseq:NM_003766.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:7tSNEY7uVWJZtQ3l1zd1xhkaoUU9606	rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606	intact-crc:A6764FAEB3DFDAB7|rigid:LgSc+l3Qry5ddwMW64O41MaUvA4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96IW2	uniprotkb:Q14457	intact:EBI-4402781|uniprotkb:Q96NC2|ensembl:ENSP00000446058	intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7	psi-mi:shd_human(display_long)|uniprotkb:SHD(gene name)|psi-mi:SHD(display_short)	psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699547|imex:IM-22632-568	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064594.3|ensembl:ENSG00000105251(gene)|go:"GO:0001784"(phosphotyrosine residue binding)|interpro:IPR000980(SH2 motif)|interpro:IPR035039|interpro:IPR035046|interpro:IPR036860|ensembl:ENST00000543264(transcript)|entrezgene/locuslink:56961(identity)|refseq:NM_020209.3(identity)	ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1|entrezgene/locuslink:8678(identity)|refseq:NM_003766.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:c2PsXxVdBB1dLj+Lu40XdgOb2yY9606	rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606	intact-crc:92DDFF55305655DE|rigid:BUA5YUaszlZ/rAxtumXvNLS/oIY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43559	uniprotkb:Q14449	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	intact:EBI-2680889|uniprotkb:B7Z7F9|uniprotkb:Q7Z6I1|ensembl:ENSP00000263915	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:grb14_human(display_long)|uniprotkb:GRB14 adapter protein(gene name synonym)|uniprotkb:GRB14(gene name)|psi-mi:GRB14(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699557|imex:IM-22632-569	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	refseq:NP_004481.2|refseq:NP_001290351.1|ensembl:ENSG00000115290(gene)|ensembl:ENST00000263915(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035034|interpro:IPR035035|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q14449|rcsb pdb:2AUG|rcsb pdb:2AUH|rcsb pdb:4K81|reactome:R-HSA-210993|go:"GO:0008286"(insulin receptor signaling pathway)|dip:DIP-42605N|entrezgene/locuslink:2888(identity)|refseq:NM_004490.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	rogid:b3Xtmki3fCyyoRra/IQWuGIQDCU9606	intact-crc:D6FBA6142096E69E|rigid:h/PrUMnmawyawYfTbcZDpLqVD10	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08631-2	uniprotkb:Q14449	intact:EBI-9834454|ensembl:ENSP00000429848|ensembl:ENSP00000486627	intact:EBI-2680889|uniprotkb:B7Z7F9|uniprotkb:Q7Z6I1|ensembl:ENSP00000263915	psi-mi:p08631-2(display_long)|uniprotkb:p59-HCK(isoform synonym)|uniprotkb:p59Hck(isoform synonym)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:grb14_human(display_long)|uniprotkb:GRB14 adapter protein(gene name synonym)|uniprotkb:GRB14(gene name)|psi-mi:GRB14(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699567|imex:IM-22632-570	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:P08631-2(isoform-parent)|intact:EBI-346340(isoform-parent)|ensembl:ENSG00000101336(gene)|ensembl:ENST00000520553(transcript)|ensembl:ENST00000629881(transcript)|entrezgene/locuslink:3055(identity)|refseq:NM_001172129.1(identity)	refseq:NP_004481.2|refseq:NP_001290351.1|ensembl:ENSG00000115290(gene)|ensembl:ENST00000263915(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035034|interpro:IPR035035|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q14449|rcsb pdb:2AUG|rcsb pdb:2AUH|rcsb pdb:4K81|reactome:R-HSA-210993|go:"GO:0008286"(insulin receptor signaling pathway)|dip:DIP-42605N|entrezgene/locuslink:2888(identity)|refseq:NM_004490.2(identity)	-	isoform-comment:Initiator Met-1 is removed. Contains a N-myristoyl glycine at position 2. Contains a S-palmitoyl cysteine at position 3.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:qSgfntp+jqdyi7qsc7u7UA7ylO09606	rogid:b3Xtmki3fCyyoRra/IQWuGIQDCU9606	intact-crc:6701A71987C3B9C7|rigid:BvkTJphHzTMxMLW5h66YEpAUZc4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q14141	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-745901|uniprotkb:Q5JTK0|uniprotkb:Q969W5|uniprotkb:Q96A13|uniprotkb:Q96GR1|uniprotkb:Q96P86|uniprotkb:Q96P87|intact:EBI-1047521|ensembl:ENSP00000341524	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:sept6_human(display_long)|uniprotkb:SEPTIN6(gene name)|psi-mi:SEPTIN6(display_short)|uniprotkb:KIAA0128(gene name synonym)|uniprotkb:SEP2(gene name synonym)|uniprotkb:SEPT6(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699577|imex:IM-22632-571	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	ensembl:ENSG00000125354(gene)|ensembl:ENST00000343984(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005819"(spindle)|go:"GO:0005940"(septin ring)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030154"(cell differentiation)|go:"GO:0030496"(midbody)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032173"(septin collar)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043679"(axon terminus)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097227"(sperm annulus)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|interpro:IPR030644|mint:Q14141|rcsb pdb:2QAG|rcsb pdb:6UPA|rcsb pdb:6WBP|refseq:NP_055944.2|refseq:NP_665798.1|refseq:NP_665799.1|refseq:NP_665801.1|refseq:XP_006724813.1|dip:DIP-38218N|refseq:NM_015129.5(identity)|entrezgene/locuslink:23157(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:gH1JHXyE/7o3I8i4ZS3bMoF7zvU9606	intact-crc:583651A5208D5917|rigid:b4YMSPAAzR9FT6UdTubVlY9e1r0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14141	uniprotkb:P46108	intact:EBI-745901|uniprotkb:Q5JTK0|uniprotkb:Q969W5|uniprotkb:Q96A13|uniprotkb:Q96GR1|uniprotkb:Q96P86|uniprotkb:Q96P87|intact:EBI-1047521|ensembl:ENSP00000341524	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:sept6_human(display_long)|uniprotkb:SEPTIN6(gene name)|psi-mi:SEPTIN6(display_short)|uniprotkb:KIAA0128(gene name synonym)|uniprotkb:SEP2(gene name synonym)|uniprotkb:SEPT6(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699587|imex:IM-22632-572	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000125354(gene)|ensembl:ENST00000343984(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005819"(spindle)|go:"GO:0005940"(septin ring)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030154"(cell differentiation)|go:"GO:0030496"(midbody)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032173"(septin collar)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043679"(axon terminus)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097227"(sperm annulus)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|interpro:IPR030644|mint:Q14141|rcsb pdb:2QAG|rcsb pdb:6UPA|rcsb pdb:6WBP|refseq:NP_055944.2|refseq:NP_665798.1|refseq:NP_665799.1|refseq:NP_665801.1|refseq:XP_006724813.1|dip:DIP-38218N|refseq:NM_015129.5(identity)|entrezgene/locuslink:23157(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:gH1JHXyE/7o3I8i4ZS3bMoF7zvU9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:7089DB3418AA84A6|rigid:qM7naK8ZVlNqrRLKQEw091ABmbY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13610	uniprotkb:Q92569	intact:EBI-1050630|uniprotkb:A8K3R6|ensembl:ENSP00000387365|uniprotkb:Q7Z3X9	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:pwp1_human(display_long)|uniprotkb:Keratinocyte protein IEF SSP 9502(gene name synonym)|uniprotkb:PWP1(gene name)|psi-mi:PWP1(display_short)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699607|imex:IM-22632-574	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_008993.1|refseq:NP_001304892.1|ensembl:ENSG00000136045(gene)|ensembl:ENST00000412830(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006364"(rRNA processing)|go:"GO:0033140"(negative regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0034773"(histone H4-K20 trimethylation)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990889"(H4K20me3 modified histone binding)|go:"GO:2000738"(positive regulation of stem cell differentiation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR044285|mint:Q13610|refseq:NM_007062.1(identity)|entrezgene/locuslink:2308(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3LMa4f6IxjpvEoh2Hyu0hHKkY789606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:52EC809C04BDCA87|rigid:gRbhQ/qjh79IMLl+MpAUhSeHSX8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q14012	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-6380130|ensembl:ENSP00000256460|uniprotkb:Q3KPF6	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:kcc1a_human(display_long)|uniprotkb:CAMK1(gene name)|psi-mi:CAMK1(display_short)|uniprotkb:CaM kinase I(gene name synonym)|uniprotkb:CaM kinase I alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699597|imex:IM-22632-573	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	ensembl:ENSG00000134072(gene)|ensembl:ENST00000256460(transcript)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0060143"(positive regulation of syncytium formation by plasma membrane fusion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901985"(positive regulation of protein acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:4FG7|rcsb pdb:4FG8|rcsb pdb:4FG9|rcsb pdb:4FGB|reactome:R-HSA-9617324|reactome:R-HSA-9619229|dip:DIP-41906N|refseq:NP_003647.1|refseq:NM_003656.4(identity)|entrezgene/locuslink:8536(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:iCIR+2Rm8PZUMsRbz2MQs22sHiU9606	intact-crc:9F640E751013DD1C|rigid:UPNS9VZH4Pid8n3xW2OdllAE/C0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:Q13569	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-348333|ensembl:ENSP00000376611|uniprotkb:Q8IUZ6|uniprotkb:Q8IZM3	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:tdg_human(display_long)|uniprotkb:TDG(gene name)|psi-mi:TDG(display_short)|uniprotkb:Thymine-DNA glycosylase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699617|imex:IM-22632-575	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	ensembl:ENSG00000139372(gene)|ensembl:ENST00000392872(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004844"(uracil DNA N-glycosylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006284"(base-excision repair)|go:"GO:0006285"(base-excision repair, AP site formation)|go:"GO:0006298"(mismatch repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0008263"(pyrimidine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031404"(chloride ion binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0035511"(oxidative DNA demethylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043739"(G/U mismatch-specific uracil-DNA glycosylase activity)|go:"GO:0045008"(depyrimidination)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0080111"(DNA demethylation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902544"(regulation of DNA N-glycosylase activity)|interpro:IPR003310("G:T/U mismatch-specific DNA glycosylase")|interpro:IPR005122(Uracil-DNA glycosylase-like)|interpro:IPR015637(DNA glycosylase, G/T mismatch)|interpro:IPR036895|mint:Q13569|rcsb pdb:1WYW|rcsb pdb:2D07|rcsb pdb:2RBA|rcsb pdb:3UFJ|rcsb pdb:3UO7|rcsb pdb:3UOB|rcsb pdb:4FNC|rcsb pdb:4JGC|rcsb pdb:4XEG|rcsb pdb:4Z3A|rcsb pdb:4Z47|rcsb pdb:4Z7B|rcsb pdb:4Z7Z|rcsb pdb:5CYS|rcsb pdb:5FF8|rcsb pdb:5HF7|rcsb pdb:5JXY|rcsb pdb:5T2W|rcsb pdb:6U15|rcsb pdb:6U16|rcsb pdb:6U17|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110357|reactome:R-HSA-3108214|reactome:R-HSA-5221030|refseq:NP_003202.3|dip:DIP-32709N|entrezgene/locuslink:6996(identity)|refseq:NM_003211.4(identity)	-	crc64:6C00632211C8012D	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:LPhuo6buYUphV9aJ456Ydq36fnU9606	intact-crc:BF71D8ED4C39A1EF|rigid:6AhrV8LOUsbhZ0IyuFxHUtkEtw8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q13569	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-348333|ensembl:ENSP00000376611|uniprotkb:Q8IUZ6|uniprotkb:Q8IZM3	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:tdg_human(display_long)|uniprotkb:TDG(gene name)|psi-mi:TDG(display_short)|uniprotkb:Thymine-DNA glycosylase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699627|imex:IM-22632-576	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	ensembl:ENSG00000139372(gene)|ensembl:ENST00000392872(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004844"(uracil DNA N-glycosylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006284"(base-excision repair)|go:"GO:0006285"(base-excision repair, AP site formation)|go:"GO:0006298"(mismatch repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0008263"(pyrimidine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031404"(chloride ion binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0035511"(oxidative DNA demethylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043739"(G/U mismatch-specific uracil-DNA glycosylase activity)|go:"GO:0045008"(depyrimidination)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0080111"(DNA demethylation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902544"(regulation of DNA N-glycosylase activity)|interpro:IPR003310("G:T/U mismatch-specific DNA glycosylase")|interpro:IPR005122(Uracil-DNA glycosylase-like)|interpro:IPR015637(DNA glycosylase, G/T mismatch)|interpro:IPR036895|mint:Q13569|rcsb pdb:1WYW|rcsb pdb:2D07|rcsb pdb:2RBA|rcsb pdb:3UFJ|rcsb pdb:3UO7|rcsb pdb:3UOB|rcsb pdb:4FNC|rcsb pdb:4JGC|rcsb pdb:4XEG|rcsb pdb:4Z3A|rcsb pdb:4Z47|rcsb pdb:4Z7B|rcsb pdb:4Z7Z|rcsb pdb:5CYS|rcsb pdb:5FF8|rcsb pdb:5HF7|rcsb pdb:5JXY|rcsb pdb:5T2W|rcsb pdb:6U15|rcsb pdb:6U16|rcsb pdb:6U17|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110357|reactome:R-HSA-3108214|reactome:R-HSA-5221030|refseq:NP_003202.3|dip:DIP-32709N|entrezgene/locuslink:6996(identity)|refseq:NM_003211.4(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:LPhuo6buYUphV9aJ456Ydq36fnU9606	intact-crc:14F1715EED6461C2|rigid:/URsLiQKtUAnh6WEjSBc9d1SjZc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75791	uniprotkb:Q13191	intact:EBI-740418|uniprotkb:B7Z8I3|uniprotkb:O43726|uniprotkb:Q9NRB7|ensembl:ENSP00000339186|ensembl:ENSP00000385607	intact:EBI-744027|uniprotkb:Q63Z43|uniprotkb:A8K9S7|uniprotkb:Q13192|uniprotkb:Q13193|uniprotkb:Q3LIC0|uniprotkb:Q8IVC5|uniprotkb:B7WNM4|intact:EBI-28969458|ensembl:ENSP00000377598|intact:EBI-8051403|intact:MINT-7907019	psi-mi:grap2_human(display_long)|uniprotkb:Protein GADS(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:Grf40 adapter protein(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:GRBX(gene name synonym)|uniprotkb:P38(gene name synonym)|uniprotkb:Hematopoietic cell-associated adapter protein GrpL(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:SH3-SH2-SH3 adapter Mona(gene name synonym)|uniprotkb:GRAP2(gene name)|psi-mi:GRAP2(display_short)|uniprotkb:GADS(gene name synonym)|uniprotkb:GRB2L(gene name synonym)|uniprotkb:GRID(gene name synonym)	psi-mi:cblb_human(display_long)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699637|imex:IM-22632-577	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278753.1|refseq:NP_001278754.1|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O75791|rcsb pdb:5GJH|reactome:R-HSA-1433557|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-389356|reactome:R-HSA-9607240|interpro:IPR000980(SH2 motif)|refseq:NP_004801.1|ensembl:ENSG00000100351(gene)|ensembl:ENST00000344138(transcript)|ensembl:ENST00000407075(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007267"(cell-cell signaling)|refseq:NP_001278757.1|dip:DIP-38435N|entrezgene/locuslink:9402(identity)|refseq:NM_004810.3(identity)	refseq:NP_733762.2|refseq:NP_001308717.1|ensembl:ENSP00000377598|ensembl:ENST00000403724|ensembl:ENSP00000384816|ensembl:ENST00000405772|ensembl:ENSP00000384938|refseq:XP_011511559.1|ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q13191|rcsb pdb:2AK5|rcsb pdb:2BZ8|rcsb pdb:2DO6|rcsb pdb:2J6F|rcsb pdb:2JNH|rcsb pdb:2LDR|rcsb pdb:2OOA|rcsb pdb:2OOB|rcsb pdb:3PFV|rcsb pdb:3VGO|rcsb pdb:3ZNI|reactome:R-HSA-983168|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|dip:DIP-33091N|entrezgene/locuslink:868(identity)|refseq:NM_170662.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:eDZoV+vaCfLAcmbcN5LlJMDiuZ09606	rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606	intact-crc:8F1B524B418DA452|rigid:7Jcy8FhxbPc52yPCYLWO38m/03E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02363	uniprotkb:Q8TB24	intact:EBI-713450|ensembl:ENSP00000234091|ensembl:ENSP00000379585|ensembl:ENSP00000385465	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	psi-mi:id2_human(display_long)|uniprotkb:Inhibitor of DNA binding 2(gene name synonym)|uniprotkb:ID2(gene name)|psi-mi:ID2(display_short)|uniprotkb:BHLHB26(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 26(gene name synonym)|uniprotkb:Inhibitor of differentiation 2(gene name synonym)	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699657|imex:IM-22632-579	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115738(gene)|ensembl:ENST00000234091(transcript)|ensembl:ENST00000331129(transcript)|ensembl:ENST00000396290(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0003166"(bundle of His development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030154"(cell differentiation)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045578"(negative regulation of B cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061031"(endodermal digestive tract morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071931"(positive regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090398"(cellular senescence)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR026052|interpro:IPR036638|mint:Q02363|rcsb pdb:4AYA|reactome:R-HSA-9031628|refseq:NP_002157.2|dip:DIP-46874N|entrezgene/locuslink:3398(identity)|refseq:NM_002166.4(identity)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:zKX4mIq64fyS8DVPGQNeL7+c50w9606	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	intact-crc:6DFBB41AE4C78E42|rigid:b+Q+4NglPDEMbrdhZDDZYootwZw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13191	uniprotkb:P06241-3	intact:EBI-744027|uniprotkb:Q63Z43|uniprotkb:A8K9S7|uniprotkb:Q13192|uniprotkb:Q13193|uniprotkb:Q3LIC0|uniprotkb:Q8IVC5|uniprotkb:B7WNM4|intact:EBI-28969458|ensembl:ENSP00000377598|intact:EBI-8051403|intact:MINT-7907019	intact:EBI-10691738|ensembl:ENSP00000229471	psi-mi:cblb_human(display_long)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:p06241-3(display_long)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:p59-Fyn(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699647|imex:IM-22632-578	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_733762.2|refseq:NP_001308717.1|ensembl:ENSP00000377598|ensembl:ENST00000403724|ensembl:ENSP00000384816|ensembl:ENST00000405772|ensembl:ENSP00000384938|refseq:XP_011511559.1|ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q13191|rcsb pdb:2AK5|rcsb pdb:2BZ8|rcsb pdb:2DO6|rcsb pdb:2J6F|rcsb pdb:2JNH|rcsb pdb:2LDR|rcsb pdb:2OOA|rcsb pdb:2OOB|rcsb pdb:3PFV|rcsb pdb:3VGO|rcsb pdb:3ZNI|reactome:R-HSA-983168|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|dip:DIP-33091N|entrezgene/locuslink:868(identity)|refseq:NM_170662.3(identity)	intact:EBI-515315(isoform-parent)|uniprotkb:P06241-3(isoform-parent)|ensembl:ENSG00000010810(gene)|ensembl:ENST00000229471(transcript)|refseq:NM_153048.3(identity)|entrezgene/locuslink:2534(identity)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606	rogid:ixo+4kzKOnoEXQlLRJhsg4vrF089606	intact-crc:1C6DEED2373603D9|rigid:fHcM3jZFrAmermlYZCIRpz8DGbg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P82650	uniprotkb:Q96IW2	intact:EBI-1050752|ensembl:ENSP00000418008|ensembl:ENSP00000505414|uniprotkb:Q9H3I1	intact:EBI-4402781|uniprotkb:Q96NC2|ensembl:ENSP00000446058	psi-mi:rt22_human(display_long)|uniprotkb:MRPS22(gene name)|psi-mi:MRPS22(display_short)|uniprotkb:C3orf5(gene name synonym)|uniprotkb:RPMS22(gene name synonym)|uniprotkb:GK002(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein mS22(gene name synonym)	psi-mi:shd_human(display_long)|uniprotkb:SHD(gene name)|psi-mi:SHD(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699677|imex:IM-22632-581	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064576.1|ensembl:ENSG00000175110(gene)|ensembl:ENST00000495075(transcript)|ensembl:ENST00000680020(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|interpro:IPR019374|mint:P82650|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|entrezgene/locuslink:56945(identity)|refseq:NM_020191.2(identity)	refseq:NP_064594.3|ensembl:ENSG00000105251(gene)|go:"GO:0001784"(phosphotyrosine residue binding)|interpro:IPR000980(SH2 motif)|interpro:IPR035039|interpro:IPR035046|interpro:IPR036860|ensembl:ENST00000543264(transcript)|entrezgene/locuslink:56961(identity)|refseq:NM_020209.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:T0htF4/rvOZUZ3RcuCjWvEg9iTE9606	rogid:c2PsXxVdBB1dLj+Lu40XdgOb2yY9606	intact-crc:BFC2EE64A927AFF3|rigid:4/+fCWzXi88NA0DtRQ/ukLHgr7s	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:P68402	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-713724|uniprotkb:A8DPS6|uniprotkb:Q6IBR6|uniprotkb:O00687|uniprotkb:Q29459|ensembl:ENSP00000435289|uniprotkb:A8DPS5|uniprotkb:E9PEJ5|uniprotkb:A8DPS7|uniprotkb:E9PLP3	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:pa1b2_human(display_long)|uniprotkb:PAF acetylhydrolase 30 kDa subunit(gene name synonym)|uniprotkb:PAF-AH subunit beta(gene name synonym)|uniprotkb:PAFAH1B2(gene name)|psi-mi:PAFAH1B2(display_short)|uniprotkb:PAFAHB(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699687|imex:IM-22632-582	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	ensembl:ENSG00000168092(gene)|ensembl:ENST00000527958(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003847"(1-alkyl-2-acetylglycerophosphocholine esterase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008247"(1-alkyl-2-acetylglycerophosphocholine esterase complex)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047179"(platelet-activating factor acetyltransferase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR013830(Esterase, SGNH hydrolase-type)|interpro:IPR036514|rcsb pdb:1VYH|reactome:R-HSA-6798695|reactome:R-HSA-6811436|refseq:NP_001296360.1|refseq:NP_001171677.1|refseq:NP_002563.1|refseq:NP_001171676.1|refseq:NP_001171675.1|refseq:NM_002572.3(identity)|entrezgene/locuslink:5049(identity)	-	crc64:6C00632211C8012D	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:lor3gsaIQ071mc4l0OfQelfuQdg9606	intact-crc:065BEEA8B252EBD1|rigid:sKlh9Z8oFApCgqS5waIWqlDreiU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q06187	uniprotkb:P82650	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	intact:EBI-1050752|ensembl:ENSP00000418008|ensembl:ENSP00000505414|uniprotkb:Q9H3I1	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:rt22_human(display_long)|uniprotkb:MRPS22(gene name)|psi-mi:MRPS22(display_short)|uniprotkb:C3orf5(gene name synonym)|uniprotkb:RPMS22(gene name synonym)|uniprotkb:GK002(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein mS22(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699667|imex:IM-22632-580	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N|refseq:NM_000061.2(identity)|entrezgene/locuslink:695(identity)	refseq:NP_064576.1|ensembl:ENSG00000175110(gene)|ensembl:ENST00000495075(transcript)|ensembl:ENST00000680020(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|interpro:IPR019374|mint:P82650|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|entrezgene/locuslink:56945(identity)|refseq:NM_020191.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	rogid:T0htF4/rvOZUZ3RcuCjWvEg9iTE9606	intact-crc:FC0DEDA5F455B17F|rigid:rHjRJaFZTcCZEU14fEbx+a17Aa0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:P62993	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699697|imex:IM-22632-583	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:210B161DA5BDD44A|rigid:8bQ6rzqgEVr2wwl1di5VScuZ3wo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62753	uniprotkb:Q8WU20	intact:EBI-356625|uniprotkb:P08227|uniprotkb:P10660|uniprotkb:Q4VBY7|uniprotkb:Q8N6Z7|ensembl:ENSP00000369757	intact:EBI-1104330|uniprotkb:O43558|uniprotkb:Q7LDQ6|uniprotkb:B0LPF2|uniprotkb:B2R684|ensembl:ENSP00000381083|ensembl:ENSP00000447241|ensembl:ENSP00000450048	psi-mi:rs6_human(display_long)|uniprotkb:RPS6(gene name)|psi-mi:RPS6(display_short)|uniprotkb:Phosphoprotein NP33(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS6(gene name synonym)|uniprotkb:OK/SW-cl.2(orf name)	psi-mi:frs2_human(display_long)|uniprotkb:FRS2(gene name)|psi-mi:FRS2(display_short)|uniprotkb:Suc1-associated neurotrophic factor target 1(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699707|imex:IM-22632-584	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001001.2|reactome:R-HSA-166208|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR014401(Ribosomal protein S6, eukaryotic)|interpro:IPR018282|mint:P62753|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6F4P|rcsb pdb:6F4Q|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|ensembl:ENSG00000137154(gene)|ensembl:ENST00000380394(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001890"(placenta development)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022605"(mammalian oogenesis stage)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030425"(dendrite)|go:"GO:0031929"(TOR signaling)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048821"(erythrocyte development)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001377(Ribosomal protein S6e)|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|dip:DIP-31507N|entrezgene/locuslink:6194(identity)|refseq:NM_001010.2(identity)	ensembl:ENSG00000166225(gene)|ensembl:ENST00000397997(transcript)|ensembl:ENST00000549921(transcript)|ensembl:ENST00000550389(transcript)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001759"(organ induction)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007185"(transmembrane receptor protein tyrosine phosphatase signaling pathway)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046619"(lens placode formation involved in camera-type eye formation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:Q8WU20|rcsb pdb:1XR0|rcsb pdb:2MFQ|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-170968|reactome:R-HSA-2219530|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|refseq:NP_001036020.1|refseq:NP_006645.3|refseq:NP_001265280.1|refseq:NP_001265282.1|refseq:NP_001265283.1|refseq:NP_001265284.1|refseq:NP_001265285.1|refseq:NP_001265286.1|refseq:XP_016874206.1|refseq:XP_016874207.1|refseq:XP_016874208.1|refseq:NM_001278357.1(identity)|entrezgene/locuslink:10818(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:beDuXCIqL99V9JlVfpzx7MdpH689606	rogid:7tSNEY7uVWJZtQ3l1zd1xhkaoUU9606	intact-crc:8C35F9D4DA3821DF|rigid:T81QG6eOxhKU7qS75tEqaxC9g9c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62191	uniprotkb:P46108-2	intact:EBI-357598|uniprotkb:P49014|uniprotkb:Q03527|uniprotkb:Q6IAW0|uniprotkb:Q96AZ3|ensembl:ENSP00000261303|uniprotkb:Q6NW36|uniprotkb:B4DR63	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:prs4_human(display_long)|uniprotkb:PSMC1(gene name)|psi-mi:PSMC1(display_short)|uniprotkb:26S proteasome AAA-ATPase subunit RPT2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 1(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699717|imex:IM-22632-585	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002793.2|ensembl:ENST00000261303(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|ensembl:ENSG00000100764(gene)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035244|interpro:IPR041569|mint:P62191|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFQ|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-8852276|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_001317141.1|refseq:XP_016876959.1|entrezgene/locuslink:5700(identity)|refseq:NM_002802.2(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oGEtU7Cv0qversbD3WQgAo5H9pM9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:C25575CF483EDCFC|rigid:Og05DMvHo0YKcT0gz2J2iGuPgxI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:P62068	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699727|imex:IM-22632-586	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N|entrezgene/locuslink:64854(identity)|refseq:NM_022832.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606	intact-crc:DD2B1D4487B0397D|rigid:0irsr+uXmEfh5DECXnOgokeRtBE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61371	uniprotkb:P16885	intact:EBI-3906896|uniprotkb:P47894|uniprotkb:P20663|ensembl:ENSP00000230658	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	psi-mi:isl1_human(display_long)|uniprotkb:ISL1(gene name)|psi-mi:ISL1(display_short)	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699737|imex:IM-22632-587	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002193.2|ensembl:ENSP00000230658|ensembl:ENSG00000016082(gene)|ensembl:ENST00000230658(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007409"(axonogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021524"(visceral motor neuron differentiation)|go:"GO:0021559"(trigeminal nerve development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031016"(pancreas development)|go:"GO:0031103"(axon regeneration)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048880"(sensory system development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060379"(cardiac muscle cell myoblast differentiation)|go:"GO:0060384"(innervation)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060931"(sinoatrial node cell development)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071657"(positive regulation of granulocyte colony-stimulating factor production)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901258"(positive regulation of macrophage colony-stimulating factor production)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:P61371|reactome:R-HSA-400511|reactome:R-HSA-9010553|refseq:NM_002202.2(identity)|entrezgene/locuslink:3670(identity)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:1eir7wLzkoqlwl4AfQuBtjjiyd09606	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	intact-crc:4D6804F30BFDFA25|rigid:ThtjGZd8h9BOCxB8E2N7areKcRw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:P61328-2	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-10699759|ensembl:ENSP00000397635|ensembl:ENSP00000507098|ensembl:ENSP00000508366|ensembl:ENSP00000393686	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:p61328-2(display_long)|uniprotkb:FGF12(gene name)|psi-mi:FGF12(display_short)|uniprotkb:FGF12B(gene name synonym)|uniprotkb:FHF1(gene name synonym)|uniprotkb:Fibroblast growth factor homologous factor 1(gene name synonym)|uniprotkb:Myocyte-activating factor(gene name synonym)|uniprotkb:FGF-12B(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699757|imex:IM-22632-589	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	ensembl:ENST00000445105(transcript)|ensembl:ENST00000450716(transcript)|ensembl:ENST00000683451(transcript)|ensembl:ENST00000683935(transcript)|ensembl:ENSG00000114279(gene)|intact:EBI-6657662(isoform-parent)|uniprotkb:P61328-2(isoform-parent)|entrezgene/locuslink:2257(identity)|refseq:NM_004113.5(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:wwsCPKlQTzV6jWf9h92gILoUFRg9606	intact-crc:97DF63EC78459CB4|rigid:q0dWF6f2wbdXA/3+XzLkbjig8t0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:P61371	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-3906896|uniprotkb:P47894|uniprotkb:P20663|ensembl:ENSP00000230658	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:isl1_human(display_long)|uniprotkb:ISL1(gene name)|psi-mi:ISL1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699747|imex:IM-22632-588	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_002193.2|ensembl:ENSP00000230658|ensembl:ENSG00000016082(gene)|ensembl:ENST00000230658(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007409"(axonogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021524"(visceral motor neuron differentiation)|go:"GO:0021559"(trigeminal nerve development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031016"(pancreas development)|go:"GO:0031103"(axon regeneration)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048880"(sensory system development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060379"(cardiac muscle cell myoblast differentiation)|go:"GO:0060384"(innervation)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060931"(sinoatrial node cell development)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071657"(positive regulation of granulocyte colony-stimulating factor production)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901258"(positive regulation of macrophage colony-stimulating factor production)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:P61371|reactome:R-HSA-400511|reactome:R-HSA-9010553|refseq:NM_002202.2(identity)|entrezgene/locuslink:3670(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:1eir7wLzkoqlwl4AfQuBtjjiyd09606	intact-crc:242EC082200E1C87|rigid:x6S3RxJ2cyPbgbdVsPlvC6+lmMg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:P51813	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-696657|uniprotkb:A6NIH9|uniprotkb:O60564|uniprotkb:Q12871|ensembl:ENSP00000308774|ensembl:ENSP00000340082|ensembl:ENSP00000350224	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:bmx_human(display_long)|uniprotkb:Bone marrow tyrosine kinase gene in chromosome X protein(gene name synonym)|uniprotkb:Epithelial and endothelial tyrosine kinase(gene name synonym)|uniprotkb:NTK38(gene name synonym)|uniprotkb:BMX(gene name)|psi-mi:BMX(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699771|imex:IM-22632-590	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_001712.1|refseq:NP_975010.1|refseq:NP_001307795.1|ensembl:ENSG00000102010(gene)|ensembl:ENST00000342014(transcript)|ensembl:ENST00000348343(transcript)|ensembl:ENST00000357607(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007498"(mesoderm development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028840|interpro:IPR035875|interpro:IPR036860|rcsb pdb:2EKX|rcsb pdb:2YS2|rcsb pdb:3SXR|rcsb pdb:3SXS|rcsb pdb:6I99|reactome:R-HSA-111465|reactome:R-HSA-1660499|entrezgene/locuslink:660(identity)|refseq:NM_001721.6(identity)	-	crc64:6C00632211C8012D	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:vEWqPrMe5xCQRPeNReXM+8Djcjg9606	intact-crc:3F6E5E36868BBC10|rigid:GjhHMywQIucLWeKfUxqV2gIvr2A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:P51813	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-696657|uniprotkb:A6NIH9|uniprotkb:O60564|uniprotkb:Q12871|ensembl:ENSP00000308774|ensembl:ENSP00000340082|ensembl:ENSP00000350224	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:bmx_human(display_long)|uniprotkb:Bone marrow tyrosine kinase gene in chromosome X protein(gene name synonym)|uniprotkb:Epithelial and endothelial tyrosine kinase(gene name synonym)|uniprotkb:NTK38(gene name synonym)|uniprotkb:BMX(gene name)|psi-mi:BMX(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699781|imex:IM-22632-591	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	refseq:NP_001712.1|refseq:NP_975010.1|refseq:NP_001307795.1|ensembl:ENSG00000102010(gene)|ensembl:ENST00000342014(transcript)|ensembl:ENST00000348343(transcript)|ensembl:ENST00000357607(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007498"(mesoderm development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028840|interpro:IPR035875|interpro:IPR036860|rcsb pdb:2EKX|rcsb pdb:2YS2|rcsb pdb:3SXR|rcsb pdb:3SXS|rcsb pdb:6I99|reactome:R-HSA-111465|reactome:R-HSA-1660499|entrezgene/locuslink:660(identity)|refseq:NM_001721.6(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:vEWqPrMe5xCQRPeNReXM+8Djcjg9606	intact-crc:CE1982C0F9D400D7|rigid:OfxRoRPTvbH7Wc6GG35S3E1qsWo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TB24	uniprotkb:P50461	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	intact:EBI-5658719|uniprotkb:Q9P131|intact:EBI-9540516|uniprotkb:S4S7M7|ensembl:ENSP00000265968|ensembl:ENSP00000431813|ensembl:ENSP00000497388	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:csrp3_human(display_long)|uniprotkb:CLP(gene name synonym)|uniprotkb:Cardiac LIM protein(gene name synonym)|uniprotkb:Cysteine-rich protein 3(gene name synonym)|uniprotkb:LIM domain protein, cardiac(gene name synonym)|uniprotkb:MLP(gene name synonym)|uniprotkb:Muscle LIM protein(gene name synonym)|uniprotkb:CSRP3(gene name)|psi-mi:CSRP3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699791|imex:IM-22632-592	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	refseq:NP_003467.1|ensembl:ENSG00000129170(gene)|ensembl:ENST00000265968(transcript)|ensembl:ENST00000533783(transcript)|ensembl:ENST00000649235(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031433"(telethonin binding)|go:"GO:0033292"(T-tubule organization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060537"(muscle tissue development)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903919"(negative regulation of actin filament severing)|go:"GO:1903920"(positive regulation of actin filament severing)|interpro:IPR001781(Zinc finger, LIM-type)|rcsb pdb:2O10|rcsb pdb:2O13|entrezgene/locuslink:8048(identity)|refseq:NM_003476.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	rogid:END0H7Mm0BQlKb0pQ3cEUoqXFmA9606	intact-crc:D4D60CBB8F1FF45B|rigid:WvkRoLjIz/Nj5HTJopWei1w2t58	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49959	uniprotkb:Q13387	intact:EBI-396513|uniprotkb:O43475|uniprotkb:B3KTC7|ensembl:ENSP00000325863	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:mre11_human(display_long)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)|uniprotkb:Double-strand break repair protein MRE11A(gene name synonym)|uniprotkb:HNGS1(gene name synonym)|uniprotkb:MRE11A(gene name synonym)|uniprotkb:Meiotic recombination 11 homolog 1(gene name synonym)|uniprotkb:Meiotic recombination 11 homolog A(gene name synonym)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699801|imex:IM-22632-593	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005581.2|refseq:NP_005582.1|refseq:XP_011541139.1|refseq:XP_016873261.1|dip:DIP-33238N|ensembl:ENSG00000020922(gene)|ensembl:ENST00000323929(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0016605"(PML body)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|go:"GO:0110025"(DNA strand resection involved in replication fork processing)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|mint:P49959|rcsb pdb:3T1I|reactome:R-HSA-1834949|reactome:R-HSA-2559586|reactome:R-HSA-3270619|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|entrezgene/locuslink:4361(identity)|refseq:NM_005590.3(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:fgwgA0BcNZ9phGBaOSYjkldDgeI9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:FE31FF5905E06E55|rigid:ePvBDXR2trtPXLuBeXOXJHRajNk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:P49757-3	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-10692196|ensembl:ENSP00000352563|ensembl:ENSP00000451117	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:p49757-3(display_long)|uniprotkb:C14orf41(gene name synonym)|uniprotkb:NUMB(gene name)|psi-mi:NUMB(display_short)|uniprotkb:Protein S171(gene name synonym)|uniprotkb:p71(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699811|imex:IM-22632-594	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	intact:EBI-915016(isoform-parent)|uniprotkb:P49757-3(isoform-parent)|ensembl:ENSG00000133961(gene)|ensembl:ENST00000359560(transcript)|ensembl:ENST00000557597(transcript)|entrezgene/locuslink:8650(identity)|refseq:NM_001005745.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:N2YwdjNBMiXeMFYxQrJDxqeNkSA9606	intact-crc:FE7570132FD43CF4|rigid:+2yeDwO0lTenfSe1LtX9YsL2KyI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:P46109	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699821|imex:IM-22632-595	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|entrezgene/locuslink:1399(identity)|refseq:NM_005207.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	intact-crc:A3B519EFDC6B9FDB|rigid:AOezx21B1+3jk6uKIxuKTXGdmKM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46109	uniprotkb:Q8TB24	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699831|imex:IM-22632-596	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|entrezgene/locuslink:1399(identity)|refseq:NM_005207.3(identity)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	intact-crc:52A572C7200A5398|rigid:lT+J8eGzd2HtaSn77sGSdVXwviM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:P46108	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699851|imex:IM-22632-598	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:C2B94DD519F8B9A1|rigid:2UAbjY2gETuEU4i4gX58TL2z69A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16591	uniprotkb:P46108	intact:EBI-1380661|uniprotkb:B4DSQ2|uniprotkb:B2RCR4|uniprotkb:H2FLB8|ensembl:ENSP00000281092	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:fer_human(display_long)|uniprotkb:Feline encephalitis virus-related kinase FER(gene name synonym)|uniprotkb:Fujinami poultry sarcoma/Feline sarcoma-related protein Fer(gene name synonym)|uniprotkb:FER(gene name)|psi-mi:FER(display_short)|uniprotkb:TYK3(gene name synonym)|uniprotkb:Proto-oncogene c-Fer(gene name synonym)|uniprotkb:Tyrosine kinase 3(gene name synonym)|uniprotkb:p94-Fer(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699841|imex:IM-22632-597	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005237.2|refseq:XP_016864719.1|refseq:XP_016864720.1|refseq:NP_001294957.1|refseq:NP_001294960.1|refseq:NP_001294967.1|refseq:XP_011541573.1|ensembl:ENSG00000151422(gene)|ensembl:ENST00000281092(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033007"(negative regulation of mast cell activation involved in immune response)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0036119"(response to platelet-derived growth factor)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038109"(Kit signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050904"(diapedesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR028539|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|interpro:IPR037452|mint:P16591|rcsb pdb:2KK6|rcsb pdb:6KC4|reactome:R-HSA-1433557|entrezgene/locuslink:2241(identity)|refseq:NM_005246.2(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:De5RYVRGihPHGxaflmxR8W9jC8M9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:03C5BD8E9B1CE474|rigid:qjKSrPXKbOMY14EAqh221VLH7IM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TB24	uniprotkb:P46108	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699861|imex:IM-22632-599	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:A0E1C662FB0D580B|rigid:/TQQVTStTedQpdbPrEHGLrambjM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42681	uniprotkb:Q7Z7G1	intact:EBI-7877438|uniprotkb:Q14220|intact:MINT-1493369|ensembl:ENSP00000264316	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	psi-mi:txk_human(display_long)|uniprotkb:TXK(gene name)|psi-mi:TXK(display_short)|uniprotkb:PTK4(gene name synonym)|uniprotkb:RLK(gene name synonym)|uniprotkb:Resting lymphocyte kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase 4(gene name synonym)	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699871|imex:IM-22632-600	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003319.2|ensembl:ENSG00000074966(gene)|ensembl:ENST00000264316(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060335"(positive regulation of interferon-gamma-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035579|interpro:IPR035870|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2DM0|reactome:R-HSA-2871809|entrezgene/locuslink:7294(identity)|refseq:NM_003328.2(identity)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	-	comment:mint	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:pc+nU4Q0ov1eZrXdtvxNAgdGh989606	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	intact-crc:A2C20A501F43D0B5|rigid:096scVVgGGirXwXTmFpaeCp9irk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:P42338	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-2609540|uniprotkb:D3DNF0|uniprotkb:Q24JU2|ensembl:ENSP00000289153|ensembl:ENSP00000418143|ensembl:ENSP00000501150	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:pk3cb_human(display_long)|uniprotkb:PIK3CB(gene name)|psi-mi:PIK3CB(display_short)|uniprotkb:PIK3C1(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699881|imex:IM-22632-601	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_006210.1|refseq:XP_011511197.1|refseq:XP_005247587.1|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0070527"(platelet aggregation)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-9027276|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9673767|reactome:R-HSA-9673770|ensembl:ENSG00000051382(gene)|ensembl:ENST00000289153(transcript)|ensembl:ENST00000477593(transcript)|ensembl:ENST00000674063(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|refseq:XP_006713722.1|refseq:XP_016862108.1|dip:DIP-44775N|refseq:NM_006219.2(identity)|entrezgene/locuslink:5291(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:Nga6TlSCXWs2NVRR5XfxvnLfWUk9606	intact-crc:1CBF54BEDDBACEA6|rigid:BEAI1ZXNpNmDGjLvEzQp41dbfHM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:P42336	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-2116585|uniprotkb:Q14CW1|uniprotkb:Q99762|ensembl:ENSP00000263967	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:pk3ca_human(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:PIK3CA(gene name)|psi-mi:PIK3CA(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699891|imex:IM-22632-602	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:XP_011511196.1|refseq:XP_006713721.1|refseq:NP_006209.2|dip:DIP-42728N|ensembl:ENSG00000121879(gene)|ensembl:ENST00000263967(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001944"(vasculature development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0043276"(anoikis)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|mint:P42336|rcsb pdb:2ENQ|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3ZIM|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4TUU|rcsb pdb:4TV3|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5DXT|rcsb pdb:5FI4|rcsb pdb:5ITD|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|rcsb pdb:5SX9|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBR|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5UL1|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6GVF|rcsb pdb:6GVG|rcsb pdb:6GVH|rcsb pdb:6GVI|rcsb pdb:6NCT|rcsb pdb:6OAC|rcsb pdb:6PYS|rcsb pdb:6VO7|rcsb pdb:7JIU|rcsb pdb:7K6M|rcsb pdb:7K6N|rcsb pdb:7K6O|rcsb pdb:7K71|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-180292|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9009391|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9027276|reactome:R-HSA-9028335|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|rcsb pdb:5DXH|reactome:R-HSA-9703465|reactome:R-HSA-9703648|refseq:NM_006218.2(identity)|entrezgene/locuslink:5290(identity)	-	-	-	figure legend:Suppl. table S4, suppl. Fig. S6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:YIZWt9VfCmyBCWYkqAEaMAEsl3w9606	intact-crc:74A75AB7051AD4CC|rigid:T3JPp0mYVJAHEZ/UMu8nDmgNyz0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41218	uniprotkb:P40763-2	intact:EBI-2829677|ensembl:ENSP00000357123	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:mnda_human(display_long)|uniprotkb:MNDA(gene name)|psi-mi:MNDA(display_short)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699901|imex:IM-22632-603	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002423.1|ensembl:ENSG00000163563(gene)|ensembl:ENST00000368141(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006968"(cellular defense response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR004020(Pyrin)|interpro:IPR004021(HIN-200/IF120x)|interpro:IPR011029(DEATH-like)|interpro:IPR040205|mint:P41218|rcsb pdb:5H7Q|rcsb pdb:5WPZ|reactome:R-HSA-6798695|rcsb pdb:2DBG|refseq:NM_002432.1(identity)|entrezgene/locuslink:4332(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	-	isoform-comment:Contains a phosphotyrosine at position 704.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:KYAX5onmaTu+MLjhSNnAgtTPgd49606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:E368C93051531EC2|rigid:yo6jdZ2OpaK+w94FGWeU0R+k19U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:P41218	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-2829677|ensembl:ENSP00000357123	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:mnda_human(display_long)|uniprotkb:MNDA(gene name)|psi-mi:MNDA(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699921|imex:IM-22632-605	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_002423.1|ensembl:ENSG00000163563(gene)|ensembl:ENST00000368141(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006968"(cellular defense response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR004020(Pyrin)|interpro:IPR004021(HIN-200/IF120x)|interpro:IPR011029(DEATH-like)|interpro:IPR040205|mint:P41218|rcsb pdb:5H7Q|rcsb pdb:5WPZ|reactome:R-HSA-6798695|rcsb pdb:2DBG|refseq:NM_002432.1(identity)|entrezgene/locuslink:4332(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:KYAX5onmaTu+MLjhSNnAgtTPgd49606	intact-crc:47F782BE66215710|rigid:iXgu4qjmG1UTh/G7DkIPZoriP/w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41218	uniprotkb:P40763	intact:EBI-2829677|ensembl:ENSP00000357123	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:mnda_human(display_long)|uniprotkb:MNDA(gene name)|psi-mi:MNDA(display_short)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699911|imex:IM-22632-604	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002423.1|ensembl:ENSG00000163563(gene)|ensembl:ENST00000368141(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006968"(cellular defense response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR004020(Pyrin)|interpro:IPR004021(HIN-200/IF120x)|interpro:IPR011029(DEATH-like)|interpro:IPR040205|mint:P41218|rcsb pdb:5H7Q|rcsb pdb:5WPZ|reactome:R-HSA-6798695|rcsb pdb:2DBG|refseq:NM_002432.1(identity)|entrezgene/locuslink:4332(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:KYAX5onmaTu+MLjhSNnAgtTPgd49606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:2169202AA6369211|rigid:c/IL2ouhFMksmwx4SN5wQEfOnoI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:P41218	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-2829677|ensembl:ENSP00000357123	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:mnda_human(display_long)|uniprotkb:MNDA(gene name)|psi-mi:MNDA(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699931|imex:IM-22632-606	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_002423.1|ensembl:ENSG00000163563(gene)|ensembl:ENST00000368141(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006968"(cellular defense response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR004020(Pyrin)|interpro:IPR004021(HIN-200/IF120x)|interpro:IPR011029(DEATH-like)|interpro:IPR040205|mint:P41218|rcsb pdb:5H7Q|rcsb pdb:5WPZ|reactome:R-HSA-6798695|rcsb pdb:2DBG|refseq:NM_002432.1(identity)|entrezgene/locuslink:4332(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:KYAX5onmaTu+MLjhSNnAgtTPgd49606	intact-crc:0FCC8257FDD98B36|rigid:1FhUeVuvjOg1zVkUzYM2id80mNQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:P41218	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-2829677|ensembl:ENSP00000357123	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:mnda_human(display_long)|uniprotkb:MNDA(gene name)|psi-mi:MNDA(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699941|imex:IM-22632-607	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	refseq:NP_002423.1|ensembl:ENSG00000163563(gene)|ensembl:ENST00000368141(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006968"(cellular defense response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR004020(Pyrin)|interpro:IPR004021(HIN-200/IF120x)|interpro:IPR011029(DEATH-like)|interpro:IPR040205|mint:P41218|rcsb pdb:5H7Q|rcsb pdb:5WPZ|reactome:R-HSA-6798695|rcsb pdb:2DBG|refseq:NM_002432.1(identity)|entrezgene/locuslink:4332(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:KYAX5onmaTu+MLjhSNnAgtTPgd49606	intact-crc:FE2EF697FD0D491F|rigid:U5AaEvE3hhZmHmkocO+KHD2Jn2U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:P31749	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699951|imex:IM-22632-608	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N|entrezgene/locuslink:207(identity)|refseq:NM_001014431.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	intact-crc:365E8C2EB650943E|rigid:p/jPdCMSlva666DEqH4foaX2WeM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28698-3	uniprotkb:P22681	intact:EBI-10699961|ensembl:ENSP00000469378	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:p28698-3(display_long)|uniprotkb:MZF1(gene name)|psi-mi:MZF1(display_short)|uniprotkb:MZF(gene name synonym)|uniprotkb:ZNF42(gene name synonym)|uniprotkb:ZSCAN6(gene name synonym)|uniprotkb:Zinc finger and SCAN domain-containing protein 6(gene name synonym)|uniprotkb:Zinc finger protein 42(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699965|imex:IM-22632-609	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-5278283(isoform-parent)|ensembl:ENSG00000099326(gene)|ensembl:ENST00000594234(transcript)|entrezgene/locuslink:7593(identity)|refseq:NM_001267033.1(identity)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:REcg3jEGqG9nMHmpfQFWHsFD62E9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:D00D27A58BD804BF|rigid:EmzefeHgnmp/6nl8cuYae/Wi4K0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14543	uniprotkb:P27348	intact:EBI-714146|uniprotkb:O14509|ensembl:ENSP00000330341	intact:EBI-359854|uniprotkb:Q567U5|uniprotkb:Q5TZU8|uniprotkb:Q9UP48|uniprotkb:D6W4Z5|ensembl:ENSP00000238081|ensembl:ENSP00000371267	psi-mi:socs3_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 3(gene name synonym)|uniprotkb:SOCS3(gene name)|psi-mi:SOCS3(display_short)|uniprotkb:CIS3(gene name synonym)|uniprotkb:SSI3(gene name synonym)	psi-mi:1433t_human(display_long)|uniprotkb:YWHAQ(gene name)|psi-mi:YWHAQ(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym)|uniprotkb:14-3-3 protein T-cell(gene name synonym)|uniprotkb:Protein HS1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699985|imex:IM-22632-611	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O14543|reactome:R-HSA-1059683|reactome:R-HSA-2586552|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8849474|reactome:R-HSA-8939242|reactome:R-HSA-8951664|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|go:"GO:0050728"(negative regulation of inflammatory response)|ensembl:ENSG00000184557(gene)|ensembl:ENST00000330871(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|refseq:NP_003946.3|entrezgene/locuslink:9021(identity)|refseq:NM_003955.4(identity)	refseq:NP_006817.1|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P27348|rcsb pdb:2BTP|rcsb pdb:5IQP|rcsb pdb:6BCR|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6KZG|rcsb pdb:6KZH|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9614399|ensembl:ENSG00000134308(gene)|ensembl:ENST00000238081(transcript)|ensembl:ENST00000381844(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|dip:DIP-27584N|entrezgene/locuslink:10971(identity)|refseq:NM_006826.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8HnU9EL52BGdud2WFZwYsv5R22I9606	rogid:3I07h/wy8qcwUJqvO1RA76qnW5U9606	intact-crc:A6FEC31447B6F4BE|rigid:Z4ZoQ312C3aYBoyE6Pe49gi+N/o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16591	uniprotkb:P27986-2	intact:EBI-1380661|uniprotkb:B4DSQ2|uniprotkb:B2RCR4|uniprotkb:H2FLB8|ensembl:ENSP00000281092	intact:EBI-9090282|ensembl:ENSP00000338554	psi-mi:fer_human(display_long)|uniprotkb:Feline encephalitis virus-related kinase FER(gene name synonym)|uniprotkb:Fujinami poultry sarcoma/Feline sarcoma-related protein Fer(gene name synonym)|uniprotkb:FER(gene name)|psi-mi:FER(display_short)|uniprotkb:TYK3(gene name synonym)|uniprotkb:Proto-oncogene c-Fer(gene name synonym)|uniprotkb:Tyrosine kinase 3(gene name synonym)|uniprotkb:p94-Fer(gene name synonym)	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699975|imex:IM-22632-610	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005237.2|refseq:XP_016864719.1|refseq:XP_016864720.1|refseq:NP_001294957.1|refseq:NP_001294960.1|refseq:NP_001294967.1|refseq:XP_011541573.1|ensembl:ENSG00000151422(gene)|ensembl:ENST00000281092(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033007"(negative regulation of mast cell activation involved in immune response)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0036119"(response to platelet-derived growth factor)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038109"(Kit signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050904"(diapedesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR028539|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|interpro:IPR037452|mint:P16591|rcsb pdb:2KK6|rcsb pdb:6KC4|reactome:R-HSA-1433557|entrezgene/locuslink:2241(identity)|refseq:NM_005246.2(identity)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:De5RYVRGihPHGxaflmxR8W9jC8M9606	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	intact-crc:AA3B15F00DBA5A59|rigid:AV290oX7pUnzVMhOIU4RRt2XQQk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:P22681	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700005|imex:IM-22632-613	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	-	-	-	figure legend:Suppl. table S4, suppl. fig. S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:EDA35845D0878AC2|rigid:XPynkuGbb/0GBQXNGhOl1yLKT84	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TB24	uniprotkb:P22735	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	intact:EBI-2562368|uniprotkb:Q197M4|ensembl:ENSP00000206765|ensembl:ENSP00000493587|uniprotkb:B4DWR7	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:tgm1_human(display_long)|uniprotkb:KTG(gene name synonym)|uniprotkb:Transglutaminase K(gene name synonym)|uniprotkb:Transglutaminase-1(gene name synonym)|uniprotkb:Epidermal TGase(gene name synonym)|uniprotkb:TGM1(gene name)|psi-mi:TGM1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10699995|imex:IM-22632-612	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	refseq:NP_000350.1|ensembl:ENSG00000092295(gene)|ensembl:ENSG00000285348(gene)|ensembl:ENST00000206765(transcript)|ensembl:ENST00000642845(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0003810"(protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031424"(keratinization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043163"(cell envelope organization)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001102(Transglutaminase, N-terminal)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR008958(Transglutaminase, C-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013808(Transglutaminase, conserved site)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR023608|interpro:IPR036238|interpro:IPR036985|interpro:IPR038765|rcsb pdb:2XZZ|reactome:R-HSA-6809371|entrezgene/locuslink:7051(identity)|refseq:NM_000359.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	rogid:5kr1FHRSfYLveMKchu772fNbkDM9606	intact-crc:EB97A025E90D9169|rigid:DLzVAMT7CGqx84Vd8mY6lYsIOgU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20155	uniprotkb:Q13387	intact:EBI-10200479|uniprotkb:Q6FGH2|ensembl:ENSP00000248701	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:isk2_human(display_long)|uniprotkb:SPINK2(gene name)|psi-mi:SPINK2(display_short)|uniprotkb:Acrosin-trypsin inhibitor(gene name synonym)|uniprotkb:Epididymis tissue protein Li 172(gene name synonym)|uniprotkb:HUSI-II(gene name synonym)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700035|imex:IM-22632-616	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258650.1|refseq:NP_001258651.1|refseq:NP_066937.1|ensembl:ENSG00000128040(gene)|ensembl:ENST00000248701(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001675"(acrosome assembly)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007286"(spermatid development)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|interpro:IPR042167|rcsb pdb:2JXD|rcsb pdb:6KBR|refseq:NM_021114.3(identity)|entrezgene/locuslink:6691(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:zIpTsfygI9LJc0BSBjC8d4sDW1s9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:31785C853CC25C99|rigid:qrD4j2/x2gOI9O15GelyO0+rpSQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75791	uniprotkb:P22681	intact:EBI-740418|uniprotkb:B7Z8I3|uniprotkb:O43726|uniprotkb:Q9NRB7|ensembl:ENSP00000339186|ensembl:ENSP00000385607	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:grap2_human(display_long)|uniprotkb:Protein GADS(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:Grf40 adapter protein(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:GRBX(gene name synonym)|uniprotkb:P38(gene name synonym)|uniprotkb:Hematopoietic cell-associated adapter protein GrpL(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:SH3-SH2-SH3 adapter Mona(gene name synonym)|uniprotkb:GRAP2(gene name)|psi-mi:GRAP2(display_short)|uniprotkb:GADS(gene name synonym)|uniprotkb:GRB2L(gene name synonym)|uniprotkb:GRID(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700015|imex:IM-22632-614	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278753.1|refseq:NP_001278754.1|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O75791|rcsb pdb:5GJH|reactome:R-HSA-1433557|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-389356|reactome:R-HSA-9607240|interpro:IPR000980(SH2 motif)|refseq:NP_004801.1|ensembl:ENSG00000100351(gene)|ensembl:ENST00000344138(transcript)|ensembl:ENST00000407075(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007267"(cell-cell signaling)|refseq:NP_001278757.1|dip:DIP-38435N|entrezgene/locuslink:9402(identity)|refseq:NM_004810.3(identity)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:eDZoV+vaCfLAcmbcN5LlJMDiuZ09606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:70CDA2B1CC60A181|rigid:rWDjbjLYtFQrl+xc9oXQCmoEMAg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:P22681	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700025|imex:IM-22632-615	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:E2207DCB11E5DA31|rigid:k26g0GwHnmTnrmN1ZPJtbNY5yGA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18847	uniprotkb:P40763	intact:EBI-712767|ensembl:ENSP00000344352|ensembl:ENSP00000355954|uniprotkb:Q5VTZ2|uniprotkb:Q6ICQ9|uniprotkb:Q7Z566|uniprotkb:Q8WYM6	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:atf3_human(display_long)|uniprotkb:Activating transcription factor 3(gene name synonym)|uniprotkb:ATF3(gene name)|psi-mi:ATF3(display_short)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700045|imex:IM-22632-617	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162772(gene)|ensembl:ENST00000341491(transcript)|ensembl:ENST00000366987(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061394"(regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990622"(CHOP-ATF3 complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029812|mint:P18847|reactome:R-HSA-380994|reactome:R-HSA-9633012|reactome:R-HSA-9648895|refseq:NP_001025458.1|refseq:NP_001665.1|refseq:XP_011507881.1|refseq:NP_001035709.1|refseq:NP_001193413.2|refseq:NP_001193415.1|refseq:NP_001193417.2|refseq:XP_005273203.1|dip:DIP-344N|entrezgene/locuslink:467(identity)|refseq:NM_001030287.3(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:4OpideXaQoVFi+x4P6iN5PG6RKY9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:387230B954F1080D|rigid:CMT3ex98ni9apH5d3jfRL1QARpA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:P18847	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-712767|ensembl:ENSP00000344352|ensembl:ENSP00000355954|uniprotkb:Q5VTZ2|uniprotkb:Q6ICQ9|uniprotkb:Q7Z566|uniprotkb:Q8WYM6	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:atf3_human(display_long)|uniprotkb:Activating transcription factor 3(gene name synonym)|uniprotkb:ATF3(gene name)|psi-mi:ATF3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700055|imex:IM-22632-618	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	ensembl:ENSG00000162772(gene)|ensembl:ENST00000341491(transcript)|ensembl:ENST00000366987(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061394"(regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990622"(CHOP-ATF3 complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029812|mint:P18847|reactome:R-HSA-380994|reactome:R-HSA-9633012|reactome:R-HSA-9648895|refseq:NP_001025458.1|refseq:NP_001665.1|refseq:XP_011507881.1|refseq:NP_001035709.1|refseq:NP_001193413.2|refseq:NP_001193415.1|refseq:NP_001193417.2|refseq:XP_005273203.1|dip:DIP-344N|entrezgene/locuslink:467(identity)|refseq:NM_001030287.3(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:4OpideXaQoVFi+x4P6iN5PG6RKY9606	intact-crc:3F6E0B40BB398BA4|rigid:K8rrBJZDfhug5zD6k82q/YbruQ0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TB24	uniprotkb:P15976	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	intact:EBI-3909284|uniprotkb:Q96GB8|ensembl:ENSP00000365858	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:gata1_human(display_long)|uniprotkb:GATA1(gene name)|psi-mi:GATA1(display_short)|uniprotkb:ERYF1(gene name synonym)|uniprotkb:GF1(gene name synonym)|uniprotkb:Eryf1(gene name synonym)|uniprotkb:GATA-binding factor 1(gene name synonym)|uniprotkb:NF-E1 DNA-binding protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700085|imex:IM-22632-621	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	refseq:NP_002040.1|ensembl:ENSG00000102145(gene)|ensembl:ENST00000376670(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030222"(eosinophil differentiation)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035854"(eosinophil fate commitment)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR029524|interpro:IPR039355|mint:P15976|rcsb pdb:6G0Q|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-983231|dip:DIP-41431N|entrezgene/locuslink:2623(identity)|refseq:NM_002049.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	rogid:Y/36ySlvsXrGtNSXa4y3Vl7iaJk9606	intact-crc:AD2C147C3CFF86EB|rigid:e97+CFpYcdSd2LXbDoGFJXNCbpE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18847	uniprotkb:Q8NEU8	intact:EBI-712767|ensembl:ENSP00000344352|ensembl:ENSP00000355954|uniprotkb:Q5VTZ2|uniprotkb:Q6ICQ9|uniprotkb:Q7Z566|uniprotkb:Q8WYM6	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	psi-mi:atf3_human(display_long)|uniprotkb:Activating transcription factor 3(gene name synonym)|uniprotkb:ATF3(gene name)|psi-mi:ATF3(display_short)	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700065|imex:IM-22632-619	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162772(gene)|ensembl:ENST00000341491(transcript)|ensembl:ENST00000366987(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061394"(regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990622"(CHOP-ATF3 complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029812|mint:P18847|reactome:R-HSA-380994|reactome:R-HSA-9633012|reactome:R-HSA-9648895|refseq:NP_001025458.1|refseq:NP_001665.1|refseq:XP_011507881.1|refseq:NP_001035709.1|refseq:NP_001193413.2|refseq:NP_001193415.1|refseq:NP_001193417.2|refseq:XP_005273203.1|dip:DIP-344N|entrezgene/locuslink:467(identity)|refseq:NM_001030287.3(identity)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:4OpideXaQoVFi+x4P6iN5PG6RKY9606	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	intact-crc:A95D19D488450DD1|rigid:eo8LZGAhM5WPs/XrfWTJUyIaym4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P104-2	uniprotkb:P18847	intact:EBI-10692909|ensembl:ENSP00000379270	intact:EBI-712767|ensembl:ENSP00000344352|ensembl:ENSP00000355954|uniprotkb:Q5VTZ2|uniprotkb:Q6ICQ9|uniprotkb:Q7Z566|uniprotkb:Q8WYM6	psi-mi:q9p104-2(display_long)|uniprotkb:DOK5(gene name)|psi-mi:DOK5(display_short)|uniprotkb:C20orf180(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 5(gene name synonym)|uniprotkb:Insulin receptor substrate 6(gene name synonym)	psi-mi:atf3_human(display_long)|uniprotkb:Activating transcription factor 3(gene name synonym)|uniprotkb:ATF3(gene name)|psi-mi:ATF3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700075|imex:IM-22632-620	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101134(gene)|ensembl:ENST00000395939(transcript)|intact:EBI-739600(isoform-parent)|uniprotkb:Q9P104-2(isoform-parent)|refseq:NM_177959.2(identity)|entrezgene/locuslink:55816(identity)	ensembl:ENSG00000162772(gene)|ensembl:ENST00000341491(transcript)|ensembl:ENST00000366987(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061394"(regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990622"(CHOP-ATF3 complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029812|mint:P18847|reactome:R-HSA-380994|reactome:R-HSA-9633012|reactome:R-HSA-9648895|refseq:NP_001025458.1|refseq:NP_001665.1|refseq:XP_011507881.1|refseq:NP_001035709.1|refseq:NP_001193413.2|refseq:NP_001193415.1|refseq:NP_001193417.2|refseq:XP_005273203.1|dip:DIP-344N|entrezgene/locuslink:467(identity)|refseq:NM_001030287.3(identity)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8p18JpE/uszPiQyb4FtcEu5QiOc9606	rogid:4OpideXaQoVFi+x4P6iN5PG6RKY9606	intact-crc:85ECC2833C0D0B46|rigid:g18xXzEBwqJPhtFTubDvgzRSxYw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16885	uniprotkb:P10768	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	intact:EBI-1052334|uniprotkb:Q5TBU8|uniprotkb:Q5TBV0|uniprotkb:Q5TBV2|uniprotkb:Q9BVJ2|ensembl:ENSP00000367992	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:estd_human(display_long)|uniprotkb:Esterase D(gene name synonym)|uniprotkb:ESD(gene name)|psi-mi:ESD(display_short)|uniprotkb:Methylumbelliferyl-acetate deacetylase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700095|imex:IM-22632-622	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	refseq:NP_001975.1|refseq:XP_011533256.1|refseq:XP_005266335.1|ensembl:ENSG00000139684(gene)|ensembl:ENST00000378720(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0016788"(hydrolase activity, acting on ester bonds)|go:"GO:0018738"(S-formylglutathione hydrolase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0046294"(formaldehyde catabolic process)|go:"GO:0047374"(methylumbelliferyl-acetate deacetylase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000801(Putative esterase)|interpro:IPR014186(S-formylglutathione hydrolase)|interpro:IPR029058|rcsb pdb:3FCX|reactome:R-HSA-156590|entrezgene/locuslink:2098(identity)|refseq:NM_001984.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	rogid:I8V/PLKeeDbsSgkLk0BADWVbDdg9606	intact-crc:238E2FC040B5C5D0|rigid:yInPKb8hFgzXt2bnqEC1wCdbH+w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:P10768	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-1052334|uniprotkb:Q5TBU8|uniprotkb:Q5TBV0|uniprotkb:Q5TBV2|uniprotkb:Q9BVJ2|ensembl:ENSP00000367992	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:estd_human(display_long)|uniprotkb:Esterase D(gene name synonym)|uniprotkb:ESD(gene name)|psi-mi:ESD(display_short)|uniprotkb:Methylumbelliferyl-acetate deacetylase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700105|imex:IM-22632-623	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_001975.1|refseq:XP_011533256.1|refseq:XP_005266335.1|ensembl:ENSG00000139684(gene)|ensembl:ENST00000378720(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0016788"(hydrolase activity, acting on ester bonds)|go:"GO:0018738"(S-formylglutathione hydrolase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0046294"(formaldehyde catabolic process)|go:"GO:0047374"(methylumbelliferyl-acetate deacetylase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000801(Putative esterase)|interpro:IPR014186(S-formylglutathione hydrolase)|interpro:IPR029058|rcsb pdb:3FCX|reactome:R-HSA-156590|entrezgene/locuslink:2098(identity)|refseq:NM_001984.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:I8V/PLKeeDbsSgkLk0BADWVbDdg9606	intact-crc:96974F609FD55772|rigid:3eDrBfksO8zHoyS6TwpqgIb51as	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TB24	uniprotkb:P10632	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	intact:EBI-2951522|ensembl:ENSP00000360317|uniprotkb:Q9UCZ9|uniprotkb:Q5VX93|uniprotkb:B0AZN2|uniprotkb:A8K9N8|uniprotkb:Q8WWB1|uniprotkb:B7Z1F6	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:cp2c8_human(display_long)|uniprotkb:CYP2C8(gene name)|psi-mi:CYP2C8(display_short)|uniprotkb:CYPIIC8(gene name synonym)|uniprotkb:Cytochrome P450 IIC2(gene name synonym)|uniprotkb:Cytochrome P450 MP-12(gene name synonym)|uniprotkb:Cytochrome P450 MP-20(gene name synonym)|uniprotkb:Cytochrome P450 form 1(gene name synonym)|uniprotkb:S-mephenytoin 4-hydroxylase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700115|imex:IM-22632-624	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	ensembl:ENSG00000138115(gene)|ensembl:ENST00000371270(transcript)|go:"GO:0002933"(lipid hydroxylation)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006082"(organic acid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008392"(arachidonic acid epoxygenase activity)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0008401"(retinoic acid 4-hydroxylase activity)|go:"GO:0016712"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|go:"GO:0017144"|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0020037"(heme binding)|go:"GO:0034875"(caffeine oxidase activity)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042573"(retinoic acid metabolic process)|go:"GO:0042738"|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0070330"(aromatase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0097267"(omega-hydroxylase P450 pathway)|go:"GO:0101020"(estrogen 16-alpha-hydroxylase activity)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1PQ2|rcsb pdb:2NNH|rcsb pdb:2NNI|rcsb pdb:2NNJ|rcsb pdb:2VN0|reactome:R-HSA-211981|reactome:R-HSA-211999|reactome:R-HSA-2142670|reactome:R-HSA-2142816|reactome:R-HSA-9027307|refseq:NP_000761.3|refseq:NP_001185782.1|refseq:NP_001185783.1|refseq:NP_001185784.1|refseq:NM_000770.3(identity)|entrezgene/locuslink:1558(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	rogid:sy4QWC5ZugTrrEVD/DQRvhGyhH09606	intact-crc:F2F1C2B42D113D7E|rigid:TOm9oaBBiSISBB6Zho7lQlGajEc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06732	uniprotkb:O75052	intact:EBI-4287089|uniprotkb:Q96QL9|ensembl:ENSP00000221476	intact:EBI-780467|uniprotkb:B7ZLF5|uniprotkb:Q3T551|uniprotkb:O43564|uniprotkb:Q5VU95|ensembl:ENSP00000355133	psi-mi:kcrm_human(display_long)|uniprotkb:CKM(gene name)|psi-mi:CKM(display_short)|uniprotkb:CKMM(gene name synonym)|uniprotkb:Creatine kinase M chain(gene name synonym)|uniprotkb:M-CK(gene name synonym)|uniprotkb:Creatine phosphokinase M-type(gene name synonym)	psi-mi:capon_human(display_long)|uniprotkb:C-terminal PDZ ligand of neuronal nitric oxide synthase protein(gene name synonym)|uniprotkb:Nitric oxide synthase 1 adaptor protein(gene name synonym)|uniprotkb:NOS1AP(gene name)|psi-mi:NOS1AP(display_short)|uniprotkb:CAPON(gene name synonym)|uniprotkb:KIAA0464(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700135|imex:IM-22632-626	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001815.2|ensembl:ENSG00000104879(gene)|ensembl:ENST00000221476(transcript)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0016301"(kinase activity)|go:"GO:0046314"(phosphocreatine biosynthetic process)|interpro:IPR000749("ATP:guanido phosphotransferase")|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR022413|interpro:IPR022414|interpro:IPR022415|interpro:IPR036802|mint:P06732|rcsb pdb:1I0E|reactome:R-HSA-71288|go:"GO:0005524"(ATP binding)|refseq:XP_016881729.1|refseq:NM_001824.4(identity)|entrezgene/locuslink:1158(identity)	refseq:NP_001119532.2|refseq:NP_001158229.1|refseq:NP_055512.1|ensembl:ENSG00000198929(gene)|ensembl:ENST00000361897(transcript)|go:"GO:0003062"(regulation of heart rate by chemical signal)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903762"(positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:2000170"(positive regulation of peptidyl-cysteine S-nitrosylation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|entrezgene/locuslink:9722(identity)|refseq:NM_014697.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:zuj1pG+YNft6wFPHLPoS+CTamkE9606	rogid:bpv0yuTlHR7wYE9SJ4krek2gJXQ9606	intact-crc:B4F01D11CB15564B|rigid:uqFyINLmkA6fwIS3Xv4Du006DZk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09132	uniprotkb:Q13387	intact:EBI-2680090|uniprotkb:B2R4E9|uniprotkb:Q96FG6|uniprotkb:Q05D77|uniprotkb:D6RCQ5|ensembl:ENSP00000424870	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:srp19_human(display_long)|uniprotkb:SRP19(gene name)|psi-mi:SRP19(display_short)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700125|imex:IM-22632-625	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191123.1|refseq:NP_003126.1|refseq:NP_001191122.1|refseq:NP_001191125.1|ensembl:ENSG00000153037(gene)|ensembl:ENST00000505459(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006617"(SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition)|go:"GO:0008312"(7S RNA binding)|go:"GO:0048500"(signal recognition particle)|interpro:IPR002778(Signal recognition particle, SRP19 subunit)|interpro:IPR036521|mint:P09132|rcsb pdb:1JID|rcsb pdb:1MFQ|rcsb pdb:1RY1|rcsb pdb:2J37|rcsb pdb:3KTV|rcsb pdb:4P3E|rcsb pdb:5M73|rcsb pdb:7NFX|reactome:R-HSA-1799339|dip:DIP-41412N|refseq:NM_003135.2(identity)|entrezgene/locuslink:6728(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:yIFmf1q6m2wQt3eaiCc1dlIQXn89606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:03738874E0818355|rigid:jwGW/7zKx0oZs+TeA92zrVnQxhM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52757	uniprotkb:P06400	intact:EBI-714925|uniprotkb:Q2M203|uniprotkb:Q75MM2|uniprotkb:A4D1A2|uniprotkb:F8QPL9|ensembl:ENSP00000222792|uniprotkb:E9PGE0|uniprotkb:B3VCF1|uniprotkb:B3VCF2|uniprotkb:B3VCF3|uniprotkb:C9J7B0|uniprotkb:B3VCF7|uniprotkb:B3VCG1	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	psi-mi:chio_human(display_long)|uniprotkb:Beta-chimerin(gene name synonym)|uniprotkb:Rho GTPase-activating protein 3(gene name synonym)|uniprotkb:CHN2(gene name)|psi-mi:CHN2(display_short)|uniprotkb:ARHGAP3(gene name synonym)|uniprotkb:BCH(gene name synonym)	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700145|imex:IM-22632-627	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001279998.1|refseq:NP_001279999.1|refseq:NP_001280000.1|refseq:NP_001280002.1|refseq:NP_001280004.1|refseq:NP_001280005.1|refseq:NP_001280006.1|refseq:NP_001280007.1|refseq:NP_001280008.1|refseq:NP_001280009.1|refseq:NP_001035025.1|refseq:NP_004058.1|interpro:IPR036860|interpro:IPR037860|mint:P52757|rcsb pdb:1XA6|reactome:R-HSA-9013149|interpro:IPR035840|ensembl:ENSG00000106069(gene)|ensembl:ENST00000222792(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR017356(N-chimaerin)|interpro:IPR020454|entrezgene/locuslink:1124(identity)|refseq:NM_004067.3(identity)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N|entrezgene/locuslink:5925(identity)|refseq:NM_000321.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:drcrV4yAbGTuSAJYNjjopBQxFDM9606	rogid:xidCNX96KlQzu160polvT61k4Zw9606	intact-crc:1D6F4D15C2CAA6C1|rigid:2LuekOpeeNHxmmX3smzaYdyd6G8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:P06400	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700155|imex:IM-22632-628	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N|entrezgene/locuslink:5925(identity)|refseq:NM_000321.2(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:xidCNX96KlQzu160polvT61k4Zw9606	intact-crc:745DF4FE85E4173D|rigid:3pKYc0Wr/4RmbnY+opttBo63wDE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06241-3	uniprotkb:P22681	intact:EBI-10691738|ensembl:ENSP00000229471	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:p06241-3(display_long)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:p59-Fyn(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700165|imex:IM-22632-629	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-515315(isoform-parent)|uniprotkb:P06241-3(isoform-parent)|ensembl:ENSG00000010810(gene)|ensembl:ENST00000229471(transcript)|refseq:NM_153048.3(identity)|entrezgene/locuslink:2534(identity)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ixo+4kzKOnoEXQlLRJhsg4vrF089606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:BCE4BA243A5D4AB6|rigid:uGwUIVS32ZloDCClgncn1Bsrgew	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06241	uniprotkb:Q92569	intact:EBI-515315|uniprotkb:Q16248|uniprotkb:Q5R3A6|uniprotkb:Q5R3A7|uniprotkb:Q8N5D7|uniprotkb:B5BU57|intact:EBI-2561531|uniprotkb:E1P557|uniprotkb:H0UI48|ensembl:ENSP00000346671|ensembl:ENSP00000357656	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:fyn_human(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700175|imex:IM-22632-630	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_005266947.1|refseq:XP_005266949.1|refseq:NP_002028.1|refseq:NP_694592.1|refseq:NP_694593.1|refseq:XP_016866139.1|refseq:XP_016866140.1|refseq:XP_016866141.1|refseq:XP_016866142.1|refseq:XP_016866143.1|dip:DIP-33876N|ensembl:ENSG00000010810(gene)|ensembl:ENST00000354650(transcript)|ensembl:ENST00000368667(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001764"(neuron migration)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0003015"(heart process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007612"(learning)|go:"GO:0007631"(feeding behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|interpro:IPR036028|interpro:IPR036860|mint:P06241|rcsb pdb:1A0N|rcsb pdb:1AOT|rcsb pdb:1AOU|rcsb pdb:1AVZ|rcsb pdb:1AZG|rcsb pdb:1EFN|rcsb pdb:1FYN|rcsb pdb:1G83|rcsb pdb:1M27|rcsb pdb:1NYF|rcsb pdb:1NYG|rcsb pdb:1SHF|rcsb pdb:1ZBJ|rcsb pdb:2DQ7|rcsb pdb:2MQI|rcsb pdb:2MRJ|rcsb pdb:2MRK|rcsb pdb:3H0F|rcsb pdb:3H0H|rcsb pdb:3H0I|rcsb pdb:3UA6|rcsb pdb:3UA7|rcsb pdb:4D8D|rcsb pdb:4EIK|rcsb pdb:4U17|rcsb pdb:4U1P|rcsb pdb:4ZNX|rcsb pdb:5ZAU|rcsb pdb:6EDF|rcsb pdb:6IPY|rcsb pdb:6IPZ|reactome:R-HSA-114604|reactome:R-HSA-1227986|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5621480|reactome:R-HSA-5621575|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-75892|reactome:R-HSA-8866376|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9706374|reactome:R-HSA-983695|reactome:R-HSA-9670439|entrezgene/locuslink:2534(identity)|refseq:NM_002037.5(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:GM5wIXENkJgPKwHN+UZBIqUfH6U9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:70EA91EC00C90A62|rigid:NGph915eB1fJcZu+GyXZxuj47Oc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12929	uniprotkb:P05154	intact:EBI-375576|uniprotkb:A6NMC3|ensembl:ENSP00000281172|ensembl:ENSP00000441867|ensembl:ENSP00000442388|ensembl:ENSP00000494689|ensembl:ENSP00000494842|ensembl:ENSP00000495722|ensembl:ENSP00000495824|ensembl:ENSP00000495956|ensembl:ENSP00000496406|ensembl:ENSP00000496516|uniprotkb:Q8N6J0|uniprotkb:B4DX66|uniprotkb:A8K6W2|uniprotkb:A8KA66	intact:EBI-722597|uniprotkb:Q07616|uniprotkb:Q9UG30|ensembl:ENSP00000333203|ensembl:ENSP00000450837|ensembl:ENSP00000451126|ensembl:ENSP00000451610	psi-mi:eps8_human(display_long)|uniprotkb:EPS8(gene name)|psi-mi:EPS8(display_short)	psi-mi:ipsp_human(display_long)|uniprotkb:Serpin A5(gene name synonym)|uniprotkb:Protein C inhibitor(gene name synonym)|uniprotkb:Plasminogen activator inhibitor 3(gene name synonym)|uniprotkb:Acrosomal serine protease inhibitor(gene name synonym)|uniprotkb:SERPINA5(gene name)|psi-mi:SERPINA5(display_short)|uniprotkb:PCI(gene name synonym)|uniprotkb:PLANH3(gene name synonym)|uniprotkb:PROCI(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700205|imex:IM-22632-633	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000645775(transcript)|ensembl:ENST00000646828(transcript)|ensembl:ENSG00000151491(gene)|ensembl:ENST00000646918(transcript)|ensembl:ENST00000647087(transcript)|ensembl:ENST00000647224(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010458"(exit from mitosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0030426"(growth cone)|go:"GO:0030832"(regulation of actin filament length)|go:"GO:0031267"(small GTPase binding)|ensembl:ENST00000281172(transcript)|ensembl:ENST00000543523(transcript)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|ensembl:ENST00000543612(transcript)|ensembl:ENST00000642278(transcript)|ensembl:ENST00000644374(transcript)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030222|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q12929|rcsb pdb:2E8M|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_004438.3|dip:DIP-32859N|entrezgene/locuslink:2059(identity)|refseq:NM_004447.5(identity)	refseq:NP_000615.3|ensembl:ENSG00000188488(gene)|ensembl:ENST00000329597(transcript)|ensembl:ENST00000553780(transcript)|ensembl:ENST00000554276(transcript)|ensembl:ENST00000554866(transcript)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002020"(protease binding)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006869"(lipid transport)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007342"(fusion of sperm to egg plasma membrane involved in single fertilization)|go:"GO:0008201"(heparin binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032190"(acrosin binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036024"(protein C inhibitor-TMPRSS7 complex)|go:"GO:0036025"(protein C inhibitor-TMPRSS11E complex)|go:"GO:0036026"(protein C inhibitor-PLAT complex)|go:"GO:0036027"(protein C inhibitor-PLAU complex)|go:"GO:0036028"(protein C inhibitor-thrombin complex)|go:"GO:0036029"(protein C inhibitor-KLK3 complex)|go:"GO:0036030"(protein C inhibitor-plasma kallikrein complex)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0061107"(seminal vesicle development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097181"(protein C inhibitor-coagulation factor V complex)|go:"GO:0097182"(protein C inhibitor-coagulation factor Xa complex)|go:"GO:0097183"(protein C inhibitor-coagulation factor XI complex)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|rcsb pdb:1LQ8|rcsb pdb:1PAI|rcsb pdb:2HI9|rcsb pdb:2OL2|rcsb pdb:2PAI|rcsb pdb:3DY0|reactome:R-HSA-140837|reactome:R-HSA-140875|dip:DIP-29869N|refseq:NM_000624.5(identity)|entrezgene/locuslink:5104(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ulBgb+4uZ7XrN4bLogRtd9I5AbY9606	rogid:I0v9RvhA3PygP1kZRJzkP31jw5k9606	intact-crc:F9D4235593C45AFB|rigid:yXnZuamoh935/8OW2VZmZ+0ugpY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06239	uniprotkb:Q8TB24	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700185|imex:IM-22632-631	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374|entrezgene/locuslink:3932(identity)|refseq:NM_001042771.2(identity)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	intact-crc:64C6B0D057B8853E|rigid:BS+xKPV/GueaFDJKRyP4NZ/jSr0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05154	uniprotkb:P22681	intact:EBI-722597|uniprotkb:Q07616|uniprotkb:Q9UG30|ensembl:ENSP00000333203|ensembl:ENSP00000450837|ensembl:ENSP00000451126|ensembl:ENSP00000451610	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:ipsp_human(display_long)|uniprotkb:Serpin A5(gene name synonym)|uniprotkb:Protein C inhibitor(gene name synonym)|uniprotkb:Plasminogen activator inhibitor 3(gene name synonym)|uniprotkb:Acrosomal serine protease inhibitor(gene name synonym)|uniprotkb:SERPINA5(gene name)|psi-mi:SERPINA5(display_short)|uniprotkb:PCI(gene name synonym)|uniprotkb:PLANH3(gene name synonym)|uniprotkb:PROCI(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700195|imex:IM-22632-632	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000615.3|ensembl:ENSG00000188488(gene)|ensembl:ENST00000329597(transcript)|ensembl:ENST00000553780(transcript)|ensembl:ENST00000554276(transcript)|ensembl:ENST00000554866(transcript)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002020"(protease binding)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006869"(lipid transport)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007342"(fusion of sperm to egg plasma membrane involved in single fertilization)|go:"GO:0008201"(heparin binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032190"(acrosin binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036024"(protein C inhibitor-TMPRSS7 complex)|go:"GO:0036025"(protein C inhibitor-TMPRSS11E complex)|go:"GO:0036026"(protein C inhibitor-PLAT complex)|go:"GO:0036027"(protein C inhibitor-PLAU complex)|go:"GO:0036028"(protein C inhibitor-thrombin complex)|go:"GO:0036029"(protein C inhibitor-KLK3 complex)|go:"GO:0036030"(protein C inhibitor-plasma kallikrein complex)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0061107"(seminal vesicle development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097181"(protein C inhibitor-coagulation factor V complex)|go:"GO:0097182"(protein C inhibitor-coagulation factor Xa complex)|go:"GO:0097183"(protein C inhibitor-coagulation factor XI complex)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|rcsb pdb:1LQ8|rcsb pdb:1PAI|rcsb pdb:2HI9|rcsb pdb:2OL2|rcsb pdb:2PAI|rcsb pdb:3DY0|reactome:R-HSA-140837|reactome:R-HSA-140875|dip:DIP-29869N|refseq:NM_000624.5(identity)|entrezgene/locuslink:5104(identity)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:I0v9RvhA3PygP1kZRJzkP31jw5k9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:16FBAA0705960FBB|rigid:KedDRPasJi7CMOkMkhnf29DXHsU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04637	uniprotkb:Q9UKG1	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700225|imex:IM-22632-635	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|refseq:NM_001126112.2(identity)|entrezgene/locuslink:7157(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:0D537DBA7F0F7BDF|rigid:bTzJCv71vsiI6MzyG7muSp3NXSI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:P04637	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700215|imex:IM-22632-634	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|refseq:NM_001126112.2(identity)|entrezgene/locuslink:7157(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	intact-crc:416D40CE520AA691|rigid:pRzS+28VZuqv9BtrWhB3uYiIodI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02795	uniprotkb:Q8TB24	intact:EBI-996616|uniprotkb:Q2HXR9|uniprotkb:Q53XT9|uniprotkb:Q14823|ensembl:ENSP00000245185	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	psi-mi:mt2_human(display_long)|uniprotkb:Metallothionein-II(gene name synonym)|uniprotkb:Metallothionein-2A(gene name synonym)|uniprotkb:MT2A(gene name)|psi-mi:MT2A(display_short)|uniprotkb:CES1(gene name synonym)|uniprotkb:MT2(gene name synonym)	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700245|imex:IM-22632-637	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005944.1|ensembl:ENSG00000125148(gene)|ensembl:ENST00000245185(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0036018"(cellular response to erythropoietin)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P02795|rcsb pdb:1MHU|rcsb pdb:2MHU|go:"GO:0006882"(cellular zinc ion homeostasis)|reactome:R-HSA-877300|reactome:R-HSA-5661231|dip:DIP-35232N|refseq:NM_005953.3(identity)|entrezgene/locuslink:4502(identity)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3adUmT5As6Rn1isYoH+jMsFKEgU9606	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	intact-crc:E3662DD721708B2B|rigid:4uYXGuA51lJeFtvqq54wlXBSpKo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03973	uniprotkb:Q13387	intact:EBI-355293|uniprotkb:P07757|uniprotkb:B2R5H8|ensembl:ENSP00000342082	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:slpi_human(display_long)|uniprotkb:SLPI(gene name)|psi-mi:SLPI(display_short)|uniprotkb:WAP4(gene name synonym)|uniprotkb:WFDC4(gene name synonym)|uniprotkb:Secretory leukocyte protease inhibitor(gene name synonym)|uniprotkb:HUSI-1(gene name synonym)|uniprotkb:Seminal proteinase inhibitor(gene name synonym)|uniprotkb:BLPI(gene name synonym)|uniprotkb:Mucus proteinase inhibitor(gene name synonym)|uniprotkb:WAP four-disulfide core domain protein 4(gene name synonym)|uniprotkb:Protease inhibitor WAP4(gene name synonym)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700235|imex:IM-22632-636	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003055.1|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008197(Whey acidic protein, 4-disulphide core)|interpro:IPR036645|rcsb pdb:2Z7F|rcsb pdb:4DOQ|reactome:R-HSA-6798695|ensembl:ENSG00000124107(gene)|ensembl:ENST00000338380(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006955"(immune response)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019899"(enzyme binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035821"(modulation of process of another organism)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|refseq:NM_003064.3(identity)|entrezgene/locuslink:6590(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:R8NGKO6Dtq5Bxw2DC1RgEtLs7/w9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:056128086B6E8905|rigid:BcXJPAclxIq1fY7fdCLIiKTjVNM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75052	uniprotkb:P00491	intact:EBI-780467|uniprotkb:B7ZLF5|uniprotkb:Q3T551|uniprotkb:O43564|uniprotkb:Q5VU95|ensembl:ENSP00000355133	intact:EBI-712238|ensembl:ENSP00000354532|uniprotkb:Q15160|uniprotkb:Q5PZ03|uniprotkb:B2R8S5|uniprotkb:D3DS00	psi-mi:capon_human(display_long)|uniprotkb:C-terminal PDZ ligand of neuronal nitric oxide synthase protein(gene name synonym)|uniprotkb:Nitric oxide synthase 1 adaptor protein(gene name synonym)|uniprotkb:NOS1AP(gene name)|psi-mi:NOS1AP(display_short)|uniprotkb:CAPON(gene name synonym)|uniprotkb:KIAA0464(gene name synonym)	psi-mi:pnph_human(display_long)|uniprotkb:Inosine phosphorylase(gene name synonym)|uniprotkb:PNP(gene name)|psi-mi:PNP(display_short)|uniprotkb:NP(gene name synonym)|uniprotkb:Inosine-guanosine phosphorylase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700265|imex:IM-22632-639	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119532.2|refseq:NP_001158229.1|refseq:NP_055512.1|ensembl:ENSG00000198929(gene)|ensembl:ENST00000361897(transcript)|go:"GO:0003062"(regulation of heart rate by chemical signal)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903762"(positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:2000170"(positive regulation of peptidyl-cysteine S-nitrosylation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|entrezgene/locuslink:9722(identity)|refseq:NM_014697.2(identity)	go:"GO:0001882"(nucleoside binding)|go:"GO:0002060"(purine nucleobase binding)|go:"GO:0004731"(purine-nucleoside phosphorylase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006148"(inosine catabolic process)|go:"GO:0006149"(deoxyinosine catabolic process)|go:"GO:0006157"(deoxyadenosine catabolic process)|go:"GO:0006166"(purine ribonucleoside salvage)|go:"GO:0006204"(IMP catabolic process)|go:"GO:0006738"(nicotinamide riboside catabolic process)|go:"GO:0006955"(immune response)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0019428"(allantoin biosynthetic process)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034418"(urate biosynthetic process)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043101"(purine-containing compound salvage)|go:"GO:0046059"(dAMP catabolic process)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0047975"(guanosine phosphorylase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000845(Nucleoside phosphorylase)|interpro:IPR011268(Inosine guanosine and xanthosine phosphorylase)|interpro:IPR011270(Purine nucleoside phosphorylase I, inosine and guanosine-specific)|interpro:IPR018099|interpro:IPR035994|mint:P00491|rcsb pdb:1M73|rcsb pdb:1PF7|rcsb pdb:1PWY|rcsb pdb:1RCT|rcsb pdb:1RFG|rcsb pdb:1RR6|rcsb pdb:1RSZ|rcsb pdb:1RT9|rcsb pdb:1ULA|rcsb pdb:1ULB|rcsb pdb:1V2H|rcsb pdb:1V3Q|rcsb pdb:1V41|rcsb pdb:1V45|rcsb pdb:1YRY|rcsb pdb:2A0W|rcsb pdb:2A0X|rcsb pdb:2A0Y|rcsb pdb:2OC4|rcsb pdb:2OC9|rcsb pdb:2ON6|rcsb pdb:2Q7O|rcsb pdb:3BGS|rcsb pdb:3D1V|rcsb pdb:3GB9|rcsb pdb:3GGS|ensembl:ENSG00000198805(gene)|ensembl:ENST00000361505(transcript)|go:"GO:0000255"(allantoin metabolic process)|rcsb pdb:3K8O|rcsb pdb:3K8Q|rcsb pdb:3PHB|rcsb pdb:4EAR|rcsb pdb:3INY|rcsb pdb:4EB8|rcsb pdb:4ECE|rcsb pdb:4GKA|rcsb pdb:5ETJ|rcsb pdb:5UGF|reactome:R-HSA-6798695|reactome:R-HSA-74217|reactome:R-HSA-74259|refseq:NP_000261.2|dip:DIP-50406N|refseq:NM_000270.3(identity)|entrezgene/locuslink:4860(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:bpv0yuTlHR7wYE9SJ4krek2gJXQ9606	rogid:FOpaxV/M6HIA+THugPZDfN1ej1o9606	intact-crc:7CE4750149E93755|rigid:LOJdnHuH2tgL2QdlV5U49JvZmGQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:P02585	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-10249681|uniprotkb:Q6FH92|ensembl:ENSP00000361636	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:tnnc2_human(display_long)|uniprotkb:TNNC2(gene name)|psi-mi:TNNC2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700255|imex:IM-22632-638	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_003270.1|ensembl:ENSG00000101470(gene)|ensembl:ENST00000372555(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005861"(troponin complex)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051015"(actin filament binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|rcsb pdb:7KAA|reactome:R-HSA-390522|refseq:NM_003279.2(identity)|entrezgene/locuslink:7125(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:tDu01LJbvR/6jD4qOObP2jSt2b89606	intact-crc:15B39B009229E537|rigid:5FuohfVEDnocC1vdCqdfhZrvaPE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:O95997	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-2551072|ensembl:ENSP00000344936|ensembl:ENSP00000377536|ensembl:ENSP00000430642	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:pttg1_human(display_long)|uniprotkb:EAP1(gene name synonym)|uniprotkb:PTTG(gene name synonym)|uniprotkb:TUTR1(gene name synonym)|uniprotkb:Pituitary tumor-transforming gene 1 protein(gene name synonym)|uniprotkb:Esp1-associated protein(gene name synonym)|uniprotkb:PTTG1(gene name)|psi-mi:PTTG1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700275|imex:IM-22632-640	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	ensembl:ENSG00000164611(gene)|ensembl:ENST00000352433(transcript)|ensembl:ENST00000393964(transcript)|ensembl:ENST00000520452(transcript)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007283"(spermatogenesis)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:2000816"(negative regulation of mitotic sister chromatid separation)|interpro:IPR006940(Securin sister-chromatid separation inhibitor)|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-2467813|refseq:NP_004210.1|refseq:NP_001269311.1|refseq:NP_001269312.1|dip:DIP-56460N|entrezgene/locuslink:9232(identity)|refseq:NM_004219.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:CsVFdecK6rCfJkLuzlnvom1nsB89606	intact-crc:2729BD2D223FD57A|rigid:Gsed9H2LLmTFStbgj08T04eHa/M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:O95777	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-347779|ensembl:ENSP00000249299	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:lsm8_human(display_long)|uniprotkb:LSM8(gene name)|psi-mi:LSM8(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700285|imex:IM-22632-641	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	refseq:NP_057284.1|dip:DIP-31195N|ensembl:ENSG00000128534(gene)|ensembl:ENST00000249299(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034103|interpro:IPR044642|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-72163|refseq:NM_016200.4(identity)|entrezgene/locuslink:51691(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:Kyf8IAEIkbe1s2NnqxqGA1o6BbU9606	intact-crc:104714046453B28A|rigid:mf5BvhQEb0X6VwKVMk4Y3hbUYDQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95704	uniprotkb:Q9UN19	intact:EBI-286427|uniprotkb:Q9NYX6|uniprotkb:Q9NYX7|uniprotkb:Q08AG4|uniprotkb:Q9NYX8|uniprotkb:B3KQN9|uniprotkb:Q96Q18|uniprotkb:Q9BYD4|ensembl:ENSP00000350171	intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602	psi-mi:apbb3_human(display_long)|uniprotkb:Protein Fe65-like 2(gene name synonym)|uniprotkb:APBB3(gene name)|psi-mi:APBB3(display_short)|uniprotkb:FE65L2(gene name synonym)	psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700295|imex:IM-22632-642	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006042.3|refseq:NP_573418.2|refseq:NP_573419.2|refseq:NP_573420.2|ensembl:ENSG00000113108(gene)|ensembl:ENST00000357560(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036020|interpro:IPR039576|rcsb pdb:2DYQ|rcsb pdb:2YSC|entrezgene/locuslink:10307(identity)|refseq:NM_133173.2(identity)	refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695|entrezgene/locuslink:27071(identity)|refseq:NM_014395.2(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:U1jEo7ZPG53cA/BcJs/BMGo/vWE9606	rogid:YYI49xKbndaB1MfL/QEovp2BF009606	intact-crc:E1D651D532DB4DA8|rigid:Uy5KPDULZ4bzUcuYizIo41kbReA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16885	uniprotkb:O95073-2	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	intact:EBI-10696047	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:o95073-2(display_long)|uniprotkb:FSBP(gene name)|psi-mi:FSBP(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700305|imex:IM-22632-643	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	intact:EBI-1059030(isoform-parent)|uniprotkb:O95073-2(isoform-parent)|refseq:NM_001256141.1(identity)|entrezgene/locuslink:25788(identity)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	rogid:j4ktleFZa7rAjRFENAKAGdAd+Fs9606	intact-crc:94833A16B0DE5240|rigid:hfYkVkDo8SgBQrgLcI7v+iRf9kM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEU8	uniprotkb:O75829-2	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	intact:EBI-10696063|ensembl:ENSP00000388576	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:o75829-2(display_long)|uniprotkb:MYETS1(gene name synonym)|uniprotkb:CNMD(gene name)|psi-mi:CNMD(display_short)|uniprotkb:CHMI(gene name synonym)|uniprotkb:Chondromodulin(gene name synonym)|uniprotkb:LECT1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700329|imex:IM-22632-645	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	intact:EBI-1220187(isoform-parent)|uniprotkb:O75829-2(isoform-parent)|ensembl:ENSG00000136110(gene)|ensembl:ENST00000448904(transcript)|refseq:NM_001011705.1(identity)|entrezgene/locuslink:11061(identity)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Suppl. table S4, suppl. fig. S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	rogid:PFYeXYbyIK2gv+GHHQBqfAR2Erg9606	intact-crc:3B857AE6740CF1B0|rigid:N/ICbwZrruuVqZ/91CLVAISip1Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O78179	uniprotkb:Q13387	intact:EBI-10700317|ensembl:ENSP00000393374	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:o78179_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLA-Cw(gene name synonym)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700315|imex:IM-22632-644	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000237022(gene)|ensembl:ENST00000438171(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019882"(antigen processing and presentation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|refseq:NM_002117.5(identity)|entrezgene/locuslink:3107(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:A67zGk1asdeHTOSGX/1ToDzxeak9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:4C5FDBBED6A54F29|rigid:XYdzcfrQSqgqr/qjmEZ8ad65Eks	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TB24	uniprotkb:O75791	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	intact:EBI-740418|uniprotkb:B7Z8I3|uniprotkb:O43726|uniprotkb:Q9NRB7|ensembl:ENSP00000339186|ensembl:ENSP00000385607	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:grap2_human(display_long)|uniprotkb:Protein GADS(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:Grf40 adapter protein(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:GRBX(gene name synonym)|uniprotkb:P38(gene name synonym)|uniprotkb:Hematopoietic cell-associated adapter protein GrpL(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:SH3-SH2-SH3 adapter Mona(gene name synonym)|uniprotkb:GRAP2(gene name)|psi-mi:GRAP2(display_short)|uniprotkb:GADS(gene name synonym)|uniprotkb:GRB2L(gene name synonym)|uniprotkb:GRID(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700339|imex:IM-22632-646	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	refseq:NP_001278753.1|refseq:NP_001278754.1|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O75791|rcsb pdb:5GJH|reactome:R-HSA-1433557|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-389356|reactome:R-HSA-9607240|interpro:IPR000980(SH2 motif)|refseq:NP_004801.1|ensembl:ENSG00000100351(gene)|ensembl:ENST00000344138(transcript)|ensembl:ENST00000407075(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007267"(cell-cell signaling)|refseq:NP_001278757.1|dip:DIP-38435N|entrezgene/locuslink:9402(identity)|refseq:NM_004810.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	rogid:eDZoV+vaCfLAcmbcN5LlJMDiuZ09606	intact-crc:002F510D1269102E|rigid:BlPvWIQePMAqOEcggZ2pZiAVYyQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:O60237-2	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-10700351|ensembl:ENSP00000349206	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:o60237-2(display_long)|uniprotkb:PPP1R12B(gene name)|psi-mi:PPP1R12B(display_short)|uniprotkb:MYPT2(gene name synonym)|uniprotkb:Myosin phosphatase-targeting subunit 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700349|imex:IM-22632-647	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	ensembl:ENSG00000077157(gene)|ensembl:ENST00000356764(transcript)|intact:EBI-2558026(isoform-parent)|uniprotkb:O60237-2(isoform-parent)|entrezgene/locuslink:4660(identity)|refseq:NM_001167858.1(identity)	-	-	isoform-comment:Produced by alternative splicing of isoform 1. No experimental confirmation available.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:vroZRva3UhIrZLt/UaNvIhLoZWI9606	intact-crc:9946ED780CA25799|rigid:GZpxdvbsipkSQ7HzykoenNWDdBs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43559	uniprotkb:P08631-2	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	intact:EBI-9834454|ensembl:ENSP00000429848|ensembl:ENSP00000486627	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:p08631-2(display_long)|uniprotkb:p59-HCK(isoform synonym)|uniprotkb:p59Hck(isoform synonym)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700373|imex:IM-22632-649	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	uniprotkb:P08631-2(isoform-parent)|intact:EBI-346340(isoform-parent)|ensembl:ENSG00000101336(gene)|ensembl:ENST00000520553(transcript)|ensembl:ENST00000629881(transcript)|entrezgene/locuslink:3055(identity)|refseq:NM_001172129.1(identity)	-	-	isoform-comment:Initiator Met-1 is removed. Contains a N-myristoyl glycine at position 2. Contains a S-palmitoyl cysteine at position 3.	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	rogid:qSgfntp+jqdyi7qsc7u7UA7ylO09606	intact-crc:A1E403356EA27894|rigid:9FHlOXWJB6TGs5laj+Z5+QcJqWk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43559	uniprotkb:O43559	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700363|imex:IM-22632-648	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	intact-crc:3D2EAB36F6EA1BDB|rigid:SQs92b+3MkA9e4CdK9s8GCo5cDw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TB24	uniprotkb:O43463	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	intact:EBI-349968|uniprotkb:Q53G60|uniprotkb:Q6FHK6|ensembl:ENSP00000365877|uniprotkb:B2R6E8|uniprotkb:B4DST0	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:suv91_human(display_long)|uniprotkb:SUV39H1(gene name)|psi-mi:SUV39H1(display_short)|uniprotkb:SUV39H(gene name synonym)|uniprotkb:KMT1A(gene name synonym)|uniprotkb:Suppressor of variegation 3-9 homolog 1(gene name synonym)|uniprotkb:Position-effect variegation 3-9 homolog(gene name synonym)|uniprotkb:Histone H3-K9 methyltransferase 1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 1A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700383|imex:IM-22632-650	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	refseq:NP_003164.1|ensembl:ENSG00000101945(gene)|ensembl:ENST00000376687(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0006325"(chromatin organization)|go:"GO:0006364"(rRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0036123"(histone H3-K9 dimethylation)|go:"GO:0036124"(histone H3-K9 trimethylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR000953(Chromo domain)|interpro:IPR001214(SET)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR011381(Histone H3-K9 methyltransferase)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|mint:O43463|rcsb pdb:3MTS|reactome:R-HSA-3214841|reactome:R-HSA-427359|refseq:NP_001269095.1|dip:DIP-32589N|refseq:NM_003173.3(identity)|entrezgene/locuslink:6839(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	rogid:dbenLwo5hxhGzFD4sLNOVUveElM9606	intact-crc:88EAEBF32B6FBFF0|rigid:1qWOfcmTNdCW9470yVKQyETb4RQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TB24	uniprotkb:O43167	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	intact:EBI-744471|uniprotkb:Q17RC6|uniprotkb:Q5TED5|uniprotkb:Q8N455|ensembl:ENSP00000230122	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:zbt24_human(display_long)|uniprotkb:Zinc finger protein 450(gene name synonym)|uniprotkb:ZBTB24(gene name)|psi-mi:ZBTB24(display_short)|uniprotkb:KIAA0441(gene name synonym)|uniprotkb:ZNF450(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700403|imex:IM-22632-652	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	refseq:NP_001157785.1|refseq:NP_055612.2|ensembl:ENSG00000112365(gene)|ensembl:ENST00000230122(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:O43167|interpro:IPR000210(BTB/POZ-like)|refseq:NM_014797.2(identity)|entrezgene/locuslink:9841(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	rogid:78JpKudyjkcnvRT5hMeTyp9rXnU9606	intact-crc:6D142AFC54574B6F|rigid:NYqyE+zfBoxhqQDdQewBKDK6plI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43242	uniprotkb:P16885	intact:EBI-357622|uniprotkb:Q96EI2|uniprotkb:Q9BQA4|ensembl:ENSP00000264639|uniprotkb:B4DT72|uniprotkb:B3KMW9	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	psi-mi:psmd3_human(display_long)|uniprotkb:PSMD3(gene name)|psi-mi:PSMD3(display_short)|uniprotkb:Proteasome subunit p58(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S3(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN3(gene name synonym)	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700393|imex:IM-22632-651	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000108344(gene)|ensembl:ENST00000264639(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|mint:O43242|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|reactome:R-HSA-174113|reactome:R-HSA-174154|rcsb pdb:5VHH|rcsb pdb:5VHI|reactome:R-HSA-174178|rcsb pdb:5VHS|reactome:R-HSA-174184|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-180534|rcsb pdb:6MSJ|reactome:R-HSA-180585|reactome:R-HSA-187577|rcsb pdb:6MSK|reactome:R-HSA-195253|reactome:R-HSA-202424|rcsb pdb:6WJD|reactome:R-HSA-211733|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-174084|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5607761|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8854050|refseq:NP_002800.2|dip:DIP-27571N|entrezgene/locuslink:5709(identity)|refseq:NM_002809.3(identity)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:C6CStW89nIAA3mzubyv5wfBwPHk9606	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	intact-crc:10D1324355FCB0A0|rigid:hHLh1EqtOW13WQftdtrcPaDZNm4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P104-2	uniprotkb:O15287	intact:EBI-10692909|ensembl:ENSP00000379270	intact:EBI-81610|ensembl:ENSP00000367910	psi-mi:q9p104-2(display_long)|uniprotkb:DOK5(gene name)|psi-mi:DOK5(display_short)|uniprotkb:C20orf180(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 5(gene name synonym)|uniprotkb:Insulin receptor substrate 6(gene name synonym)	psi-mi:fancg_human(display_long)|uniprotkb:FANCG(gene name)|psi-mi:FANCG(display_short)|uniprotkb:XRCC9(gene name synonym)|uniprotkb:DNA repair protein XRCC9(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700413|imex:IM-22632-653	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101134(gene)|ensembl:ENST00000395939(transcript)|intact:EBI-739600(isoform-parent)|uniprotkb:Q9P104-2(isoform-parent)|refseq:NM_177959.2(identity)|entrezgene/locuslink:55816(identity)	ensembl:ENSG00000221829(gene)|refseq:NP_004620.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007286"(spermatid development)|go:"GO:0009314"(response to radiation)|ensembl:ENST00000378643(transcript)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039684|mint:O15287|rcsb pdb:7KZP|rcsb pdb:7KZQ|go:"GO:0001541"(ovarian follicle development)|rcsb pdb:7KZR|go:"GO:0003684"(damaged DNA binding)|rcsb pdb:7KZS|go:"GO:0005654"(nucleoplasm)|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|go:"GO:0005730"(nucleolus)|refseq:NM_004629.1(identity)|entrezgene/locuslink:2189(identity)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8p18JpE/uszPiQyb4FtcEu5QiOc9606	rogid:jVGeic2vn/qrZgro3IKXWhNteHo9606	intact-crc:E8CDC4CF3A9C5DAC|rigid:JLXdRX0DPlpO7idYKCSOttC4sOM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14796	uniprotkb:Q13387	intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700423|imex:IM-22632-654	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933|entrezgene/locuslink:117157(identity)|refseq:NM_053282.4(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:1A7734D6E8E63390|rigid:Vr/HjeIGVEKowG/65isU6EPcUwg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43559	uniprotkb:O14544	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	intact:EBI-3929549|uniprotkb:Q8WUM3|ensembl:ENSP00000381034|ensembl:ENSP00000463395	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:socs6_human(display_long)|uniprotkb:SOCS6(gene name)|psi-mi:SOCS6(display_short)|uniprotkb:CIS4(gene name synonym)|uniprotkb:SOCS4(gene name synonym)|uniprotkb:Cytokine-inducible SH2 protein 4(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700433|imex:IM-22632-655	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	interpro:IPR037345|mint:O14544|rcsb pdb:2VIF|reactome:R-HSA-1433559|reactome:R-HSA-8951664|reactome:R-HSA-9706369|interpro:IPR036860|ensembl:ENSG00000170677(gene)|ensembl:ENST00000397942(transcript)|ensembl:ENST00000582322(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028421|interpro:IPR035865|interpro:IPR036036|refseq:NP_004223.2|refseq:XP_005266840.1|refseq:XP_016881575.1|refseq:XP_016881576.1|refseq:NM_004232.3(identity)|entrezgene/locuslink:9306(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	rogid:O++hp+HHhT2m2QNupHdNfK5DBqQ9606	intact-crc:13EF8882EE96DB64|rigid:9ZrVzHd3dQhTl/9596b5dgaa6TU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:O14544	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-3929549|uniprotkb:Q8WUM3|ensembl:ENSP00000381034|ensembl:ENSP00000463395	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:socs6_human(display_long)|uniprotkb:SOCS6(gene name)|psi-mi:SOCS6(display_short)|uniprotkb:CIS4(gene name synonym)|uniprotkb:SOCS4(gene name synonym)|uniprotkb:Cytokine-inducible SH2 protein 4(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700443|imex:IM-22632-656	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	interpro:IPR037345|mint:O14544|rcsb pdb:2VIF|reactome:R-HSA-1433559|reactome:R-HSA-8951664|reactome:R-HSA-9706369|interpro:IPR036860|ensembl:ENSG00000170677(gene)|ensembl:ENST00000397942(transcript)|ensembl:ENST00000582322(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028421|interpro:IPR035865|interpro:IPR036036|refseq:NP_004223.2|refseq:XP_005266840.1|refseq:XP_016881575.1|refseq:XP_016881576.1|refseq:NM_004232.3(identity)|entrezgene/locuslink:9306(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:O++hp+HHhT2m2QNupHdNfK5DBqQ9606	intact-crc:3DFAC2FC3C1D532F|rigid:pEf3WEGZIi0h8TAk3sdOqLDLdqY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00522	uniprotkb:Q9BSQ5	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700463|imex:IM-22632-658	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK|entrezgene/locuslink:889(identity)|refseq:NM_194454.1(identity)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N|refseq:NM_031443.3(identity)|entrezgene/locuslink:83605(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	intact-crc:D7F3986F689A7721|rigid:D4TuNCybE4z1XQ1ZZRgZbRz+9Mo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00522	uniprotkb:O14713	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	intact:EBI-2127319|uniprotkb:O14714|uniprotkb:D6W4Y9|uniprotkb:Q53RS0|ensembl:ENSP00000347504|ensembl:ENSP00000353850	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:itbp1_human(display_long)|uniprotkb:ITGB1BP1(gene name)|psi-mi:ITGB1BP1(display_short)|uniprotkb:ICAP1(gene name synonym)|uniprotkb:Integrin cytoplasmic domain-associated protein 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700453|imex:IM-22632-657	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK|entrezgene/locuslink:889(identity)|refseq:NM_194454.1(identity)	refseq:XP_011508718.1|refseq:NP_004754.1|refseq:NP_071729.1|refseq:XP_016860758.1|refseq:XP_016860759.1|refseq:XP_016860756.1|refseq:XP_016860757.1|refseq:NP_001305995.1|refseq:NP_001305996.1|refseq:NP_001305997.1|refseq:XP_006711966.1|refseq:XP_005246240.1|refseq:XP_005246241.1|refseq:XP_005246242.1|refseq:XP_005246246.1|ensembl:ENSG00000119185(gene)|ensembl:ENST00000355346(transcript)|ensembl:ENST00000360635(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006933"(negative regulation of cell adhesion involved in substrate-bound cell migration)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033622"(integrin activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035148"(tube formation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051451"(myoblast migration)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090315"(negative regulation of protein targeting to membrane)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR019517|rcsb pdb:1K11|rcsb pdb:4DX8|rcsb pdb:4DX9|rcsb pdb:4JIF|refseq:NM_004763.3(identity)|entrezgene/locuslink:9270(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rogid:QxRmizA77Dvcwg8rkqt1bt3sI2U9606	intact-crc:EDC1A47A97890A04|rigid:OgNMoav0oqlJfhzRQmXWwF0BTvc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00233	uniprotkb:Q8TB24	intact:EBI-750973|uniprotkb:Q9BQ42|uniprotkb:G3V1Q6|uniprotkb:B2RD35|intact:EBI-28988356|ensembl:ENSP00000440485	intact:EBI-1570523|uniprotkb:Q8NF30|uniprotkb:Q8TEE8|uniprotkb:Q8WYP4|uniprotkb:Q9H6A5|uniprotkb:Q9HAG1|uniprotkb:Q76LB3|ensembl:ENSP00000216487	psi-mi:psmd9_human(display_long)|uniprotkb:26S proteasome regulatory subunit p27(gene name synonym)|uniprotkb:PSMD9(gene name)|psi-mi:PSMD9(display_short)	psi-mi:rin3_human(display_long)|uniprotkb:RIN3(gene name)|psi-mi:RIN3(display_short)|uniprotkb:Ras interaction/interference protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700483|imex:IM-22632-660	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002804.2|refseq:NP_001248329.1|ensembl:ENST00000537407|ensembl:ENSP00000445058|ensembl:ENSP00000440485|ensembl:ENST00000542602|ensembl:ENSP00000443772|ensembl:ENSG00000110801(gene)|ensembl:ENST00000541212(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0070682"(proteasome regulatory particle assembly)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR035269|interpro:IPR036034|interpro:IPR040815|interpro:IPR041489|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|go:"GO:0003713"(transcription coactivator activity)|entrezgene/locuslink:5715(identity)|refseq:NM_002813.6(identity)	refseq:NP_001306916.1|refseq:NP_079108.3|ensembl:ENSG00000100599(gene)|ensembl:ENST00000216487(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060755"(negative regulation of mast cell chemotaxis)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR035869|interpro:IPR036860|interpro:IPR037191|rcsb pdb:3U23|rcsb pdb:4WCI|reactome:R-HSA-8876198|entrezgene/locuslink:79890(identity)|refseq:NM_024832.3(identity)	-	-	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:OkUTrgO5lFTumVtMd+3vZTf3TPc9606	rogid:OoBIkofek2Ytk+FAw+dANFSfGl49606	intact-crc:377CB4228C026892|rigid:bb0UDnnMpYzJi6jQ68fKruKSp28	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00292	uniprotkb:Q13387	intact:EBI-3921468|uniprotkb:Q8NBQ9|uniprotkb:O75611|uniprotkb:Q5TE89|uniprotkb:B3KNH4|ensembl:ENSP00000355785|uniprotkb:B4E332|uniprotkb:E9PDM4	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:lfty2_human(display_long)|uniprotkb:LEFTY2(gene name)|psi-mi:LEFTY2(display_short)|uniprotkb:EBAF(gene name synonym)|uniprotkb:LEFTA(gene name synonym)|uniprotkb:LEFTYA(gene name synonym)|uniprotkb:TGFB4(gene name synonym)|uniprotkb:Endometrial bleeding-associated factor(gene name synonym)|uniprotkb:Left-right determination factor A(gene name synonym)|uniprotkb:Protein lefty-2(gene name synonym)|uniprotkb:Protein lefty-A(gene name synonym)|uniprotkb:Transforming growth factor beta-4(gene name synonym)|uniprotkb:PSEC0024(orf name)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700473|imex:IM-22632-659	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003231.2|ensembl:ENSG00000143768(gene)|ensembl:ENST00000366820(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR029034|reactome:R-HSA-114608|reactome:R-HSA-1181150|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|reactome:R-HSA-1433617|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003942(Transforming growth factor, beta 4)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|refseq:NP_001165896.1|entrezgene/locuslink:7044(identity)|refseq:NM_003240.3(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	figure legend:Suppl. table S4, suppl. fig. S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:L7l3Csxv5B1zsEz0KfZFIM4J52M9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:6897E37468D07F7F|rigid:s/bATMU8kGYWKJk4x7PDGjo9cio	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-10952387	uniprotkb:Q18PE1	-	intact:EBI-3046647|ensembl:ENSP00000344432|uniprotkb:E9PB56|uniprotkb:Q8NBC1|uniprotkb:Q86XG5|uniprotkb:Q8N2J3|uniprotkb:A2A499|uniprotkb:Q6P6A6|uniprotkb:A2RRD4	psi-mi:ypel3(display_short)|psi-mi:EBI-10952387(display_long)	psi-mi:dok7_human(display_long)|uniprotkb:DOK7(gene name)|psi-mi:DOK7(display_short)|uniprotkb:C4orf25(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 7(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700496|imex:IM-22632-661	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	entrezgene/locuslink:83719(identity)|refseq:NM_031477.4(identity)	ensembl:ENSG00000175920(gene)|ensembl:ENST00000340083(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045202"(synapse)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037746|interpro:IPR037747|interpro:IPR037748|refseq:NP_001288000.1|refseq:NP_001158145.1|refseq:NP_775931.3|refseq:NP_001243825.1|refseq:NM_173660.4(identity)|entrezgene/locuslink:285489(identity)	-	no-uniprot-update:	-	figure legend:Suppl. table S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/07/31	rogid:BwRyrQctDC8gtogwo/3nXomJ8MA9606	rogid:RNSUGsyQVitqfrm+mTmzf0fZHR49606	intact-crc:255DBF66FC022568|rigid:KSwzc2zqkEPQsA9G6zt784ENqKw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q5SXH7-1	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-26412802	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:q5sxh7-1(display_long)|uniprotkb:PLEKHS1(gene name)|psi-mi:PLEKHS1(display_short)|uniprotkb:C10orf81(gene name synonym)|uniprotkb:Epididymis luminal protein 185(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700508|imex:IM-22632-662	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	intact:EBI-10691507(isoform-parent)|entrezgene/locuslink:79949(identity)|refseq:XM_005270162.2(identity)	-	-	-	agonist:"ABL2  (P42684)"|figure legend:Suppl. table S9, fig. 3B, 3C and 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2020/10/22	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:8OuCSDcvw9rtC0JZC596NetxIKA9606	intact-crc:DC87E6BE5270D1A4|rigid:/gCqH01nPA8E1ZE/l/NkTtgRxWo	false	mutation decreasing interaction:90-90,383-383|mutation decreasing interaction:383-383|firefly luciferase protein tag:n-n|mutation decreasing interaction:90-90	protein a tag:n-n|sufficient binding region:181-462	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q66PJ3-4	uniprotkb:Q92569	intact:EBI-5280499	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:q66pj3-4(display_long)|uniprotkb:Splicing factor SRrp37(gene name synonym)|uniprotkb:ARL6IP4(gene name)|psi-mi:ARL6IP4(display_short)|uniprotkb:HSP-975(gene name synonym)|uniprotkb:HSVI-binding protein(gene name synonym)|uniprotkb:SR-15(gene name synonym)|uniprotkb:SRp25(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700530|imex:IM-22632-663	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2683099(isoform-parent)|uniprotkb:Q66PJ3-4(isoform-parent)|entrezgene/locuslink:51329(identity)|refseq:NM_001002252.2(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. tables S8 and S9, fig. 3C and 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:XZT/eX9V6PNVyIyUg7RvZpH0Ydg9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:28F9EFD8B37E13BE|rigid:mCY4QnCt4aqMHLGj3Yv+CkaHsT0	false	firefly luciferase protein tag:n-n|sufficient binding region:185-399	mutation decreasing interaction:90-90,383-383|mutation disrupting interaction:90-90|protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q9NPB6-2	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-10693102|ensembl:ENSP00000392388	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:q9npb6-2(display_long)|uniprotkb:PARD6A(gene name)|psi-mi:PARD6A(display_short)|uniprotkb:PAR6A(gene name synonym)|uniprotkb:PAR6C(gene name synonym)|uniprotkb:Tax interaction protein 40(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700551|imex:IM-22632-664	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	intact:EBI-81876(isoform-parent)|ensembl:ENSG00000102981(gene)|ensembl:ENST00000458121(transcript)|uniprotkb:Q9NPB6-2(isoform-parent)|refseq:NM_001037281.1(identity)|entrezgene/locuslink:50855(identity)	-	-	-	figure legend:Suppl. tables S8 and S9, fig. 3C and 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:hLX1kt+/BGPnr4HvpWndVysxrTU9606	intact-crc:F9F3C841AAC9D232|rigid:K1GhwAs/nCfrSXIkvVeP3DngJUo	false	mutation disrupting interaction:90-90|mutation decreasing interaction:90-90,383-383|protein a tag:n-n|mutation disrupting interaction:383-383	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WXH5	uniprotkb:Q92569	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700572|imex:IM-22632-665	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. tables S8 and S9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:36036BB63548A8EF|rigid:7zpzclblMW0lSAxlChMrga4jppg	false	firefly luciferase protein tag:n-n	mutation disrupting interaction:90-90|mutation disrupting interaction:383-383|mutation disrupting interaction:90-90,383-383|protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N6F8	uniprotkb:Q92569	intact:EBI-8487781|intact:MINT-8417729|ensembl:ENSP00000297873	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:met27_human(display_long)|uniprotkb:METTL27(gene name)|psi-mi:METTL27(display_short)|uniprotkb:WBSCR27(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 27 protein(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700593|imex:IM-22632-666	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_689772.2|ensembl:ENSG00000165171(gene)|ensembl:ENST00000297873(transcript)|go:"GO:0008168"(methyltransferase activity)|interpro:IPR029063|interpro:IPR041698|mint:Q8N6F8|refseq:NM_152559.2(identity)|entrezgene/locuslink:155368(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	comment:mint|comment:homomint	-	figure legend:Suppl. tables S8 and S9, fig. 3C and 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:T+4JBqFxUvWNzHLf1bT6SGLCaJs9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:DC4B6B88B9CA15D5|rigid:i8+QJHaDs3uOblDGVBIEw3h7VDw	false	firefly luciferase protein tag:n-n	protein a tag:n-n|mutation disrupting interaction:383-383|mutation decreasing interaction:90-90,383-383|mutation disrupting interaction:90-90	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N2H9	uniprotkb:Q92569	intact:EBI-448457|uniprotkb:Q8N3E1|uniprotkb:Q8N9Q6|uniprotkb:Q8TAW7|uniprotkb:Q8TED5|ensembl:ENSP00000322532	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:peli3_human(display_long)|uniprotkb:PELI3(gene name)|psi-mi:PELI3(display_short)|uniprotkb:RING-type E3 ubiquitin transferase pellino homolog 3(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700614|imex:IM-22632-667	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001091980.1|refseq:NP_001230064.1|refseq:NP_659502.2|refseq:NP_001230065.1|refseq:XP_011543186.1|refseq:XP_016872954.1|dip:DIP-31770N|ensembl:ENSG00000174516(gene)|ensembl:ENST00000320740(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008592"(regulation of Toll signaling pathway)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR006800(Pellino)|mint:Q8N2H9|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-975144|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|entrezgene/locuslink:246330(identity)|refseq:NM_145065.2(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. tables S8 and S9, fig. 3C and 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:rj8IvjYfW2mL1sK2/f6O2cinMNo9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:8AD1696E8B7673B3|rigid:a80TH7qq+xv4XUWoZnk/icRsUqQ	false	firefly luciferase protein tag:n-n	mutation disrupting interaction:383-383|mutation decreasing interaction:90-90,383-383|protein a tag:n-n|mutation disrupting interaction:90-90	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6GQQ9	uniprotkb:Q92569	intact:EBI-527784|uniprotkb:Q8WWA7|uniprotkb:Q9NQ53|uniprotkb:Q9UFF4|uniprotkb:Q5SZ60|ensembl:ENSP00000462729|uniprotkb:D3DUZ8|uniprotkb:B7Z643	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:otu7b_human(display_long)|uniprotkb:Zinc finger protein Cezanne(gene name synonym)|uniprotkb:Zinc finger A20 domain-containing protein 1(gene name synonym)|uniprotkb:Cellular zinc finger anti-NF-kappa-B protein(gene name synonym)|uniprotkb:OTUD7B(gene name)|psi-mi:OTUD7B(display_short)|uniprotkb:ZA20D1(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700635|imex:IM-22632-668	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-33805N|ensembl:ENSG00000264522(gene)|ensembl:ENST00000581312(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003323(Ovarian tumour, otubain)|rcsb pdb:5LRU|rcsb pdb:5LRV|rcsb pdb:5LRW|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689896|ensembl:ENSP00000462729|refseq:NP_064590.2|refseq:NM_020205.3(identity)|entrezgene/locuslink:56957(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. tables S8 and S9, fig. 3C and 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:JZKj6CpuUOQ3aqvmg3YC9OnivGM9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:4479E0385DD46D03|rigid:n61cEsKi8pHx3kMuj8eQZIsQ3vw	false	firefly luciferase protein tag:n-n	mutation disrupting interaction:90-90|mutation disrupting interaction:383-383|protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:P35568	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700656|imex:IM-22632-669	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772|refseq:NM_005544.2(identity)|entrezgene/locuslink:3667(identity)	-	-	-	figure legend:Suppl. table S9, fig. 3C and 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	intact-crc:D25323F385E3B6EF|rigid:JTCBBkGf9heSVjXJrI8dklyOaoA	false	mutation:90-90|protein a tag:n-n|mutation:383-383|mutation:90-90,383-383	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q9NP31	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700677|imex:IM-22632-670	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	figure legend:Suppl. tables S8 and S9, fig. 3C and 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:F14AA9CEFDA9CCD8|rigid:9IhtipCdg1OD6tsl6/DeyNKPvC0	false	protein a tag:n-n|mutation disrupting interaction:90-90|mutation decreasing interaction:90-90,383-383|mutation decreasing interaction:383-383	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99619	uniprotkb:Q92569	intact:EBI-2323209|uniprotkb:D3DUT0|uniprotkb:B7Z4W1|ensembl:ENSP00000428338|ensembl:ENSP00000430872	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:spsb2_human(display_long)|uniprotkb:SPSB2(gene name)|psi-mi:SPSB2(display_short)|uniprotkb:GRCC9(gene name synonym)|uniprotkb:SSB2(gene name synonym)|uniprotkb:Gene-rich cluster protein C9(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700696|imex:IM-22632-671	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139788.1|refseq:NP_116030.1|refseq:NP_001306599.1|ensembl:ENSG00000111671(gene)|ensembl:ENST00000523102(transcript)|ensembl:ENST00000524270(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036036|interpro:IPR037340|interpro:IPR043136|mint:Q99619|rcsb pdb:3EMW|rcsb pdb:5XN3|rcsb pdb:6DN5|rcsb pdb:6DN6|rcsb pdb:6JKJ|rcsb pdb:6JWM|rcsb pdb:6JWN|rcsb pdb:6KEY|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NM_001146316.1(identity)|entrezgene/locuslink:84727(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. tables S8 and S9, fig. 3C and 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:d9ATBVBuRYT4OE5DV+pjGasS9qs9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:81CFAED37377E649|rigid:FD/bq5YQHQ4pqVjedrPniNx9GTs	false	firefly luciferase protein tag:n-n	mutation decreasing interaction:90-90,383-383|protein a tag:n-n|mutation disrupting interaction:90-90|mutation decreasing interaction:383-383	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:P53672	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-750444|uniprotkb:Q9Y562|uniprotkb:Q4ZFX0|ensembl:ENSP00000295728|ensembl:ENSP00000375946	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:crba2_human(display_long)|uniprotkb:Beta-A2 crystallin(gene name synonym)|uniprotkb:CRYBA2(gene name)|psi-mi:CRYBA2(display_short)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700715|imex:IM-22632-672	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_476434.1|refseq:NP_476435.1|ensembl:ENSG00000163499(gene)|ensembl:ENST00000295728(transcript)|ensembl:ENST00000392096(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|mint:P53672|entrezgene/locuslink:1412(identity)|refseq:NM_057094.1(identity)	-	-	-	figure legend:Suppl. table S9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:/WkdaQ4LTxa9mpIiOwVuhd375mE9606	intact-crc:B59AE8155CD6CBA7|rigid:QiwDJtJbxb1JQtZfon0yBo8GD+g	false	protein a tag:n-n|mutation:383-383|mutation:90-90,383-383	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:P08631-2	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-9834454|ensembl:ENSP00000429848|ensembl:ENSP00000486627	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:p08631-2(display_long)|uniprotkb:p59-HCK(isoform synonym)|uniprotkb:p59Hck(isoform synonym)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700734|imex:IM-22632-673	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	uniprotkb:P08631-2(isoform-parent)|intact:EBI-346340(isoform-parent)|ensembl:ENSG00000101336(gene)|ensembl:ENST00000520553(transcript)|ensembl:ENST00000629881(transcript)|entrezgene/locuslink:3055(identity)|refseq:NM_001172129.1(identity)	-	-	isoform-comment:Initiator Met-1 is removed. Contains a N-myristoyl glycine at position 2. Contains a S-palmitoyl cysteine at position 3.	figure legend:Suppl. table S9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:qSgfntp+jqdyi7qsc7u7UA7ylO09606	intact-crc:689ED918D411D33F|rigid:qfJOe/FsOciLbpYBqVn5AZMH/88	false	mutation:90-90,383-383|protein a tag:n-n|mutation:90-90	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:Q53HF2	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-877761	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:q53hf2_human(display_long)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700753|imex:IM-22632-674	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	go:"GO:0005524"(ATP binding)|refseq:NP_006588.1|refseq:NP_694881.1|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR043129|refseq:NM_153201.3(identity)|entrezgene/locuslink:3303(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:m6Qk8kbAwVk7YILzmsVDpzKHUvE9606	intact-crc:72BCB51ACCC92C4B|rigid:Ajvkjg2E/rcWSLUO5M0cGM6Ey4o	false	firefly luciferase protein tag:n-n	sufficient binding region:12-203|protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q53HF2	uniprotkb:O14796	intact:EBI-877761	intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906	psi-mi:q53hf2_human(display_long)	psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700769|imex:IM-22632-675	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|refseq:NP_006588.1|refseq:NP_694881.1|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR043129|refseq:NM_153201.3(identity)|entrezgene/locuslink:3303(identity)	refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933|entrezgene/locuslink:117157(identity)|refseq:NM_053282.4(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:m6Qk8kbAwVk7YILzmsVDpzKHUvE9606	rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606	intact-crc:9FADC373849D2845|rigid:4XU6qktSmuvuPHcfeP+LX8pbcUQ	false	sufficient binding region:12-203|protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TAK6	uniprotkb:O14796	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700785|imex:IM-22632-676	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933|entrezgene/locuslink:117157(identity)|refseq:NM_053282.4(identity)	-	-	-	agonist:"ABL2  (P42684)"|figure legend:Suppl. table S8, fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606	intact-crc:D7C22241C3DB8479|rigid:6IP/ELSX2myGNdMemehffrOFpkU	false	sufficient binding region:17-271|protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13322	uniprotkb:Q9UKA8	intact:EBI-80275|uniprotkb:O00427|uniprotkb:O00701|uniprotkb:O75222|uniprotkb:Q92606|uniprotkb:Q92907|uniprotkb:Q92948|intact:EBI-1760363|ensembl:ENSP00000381793|ensembl:ENSP00000385770|intact:EBI-1965437|uniprotkb:A7VJ95|uniprotkb:A4D258|uniprotkb:A8K0E6|uniprotkb:D3DVM9	intact:EBI-9091952|uniprotkb:A4GU14|uniprotkb:Q9UKA7|uniprotkb:E7ENV1|uniprotkb:Q5ECL3|uniprotkb:A4LA69|uniprotkb:Q5TGC6|uniprotkb:E7EWD8|uniprotkb:Q9NUC8|uniprotkb:E3VWE2|uniprotkb:E5L4P0|uniprotkb:E5L4P7|uniprotkb:G1FI66|uniprotkb:G1FLF0|ensembl:ENSP00000363516|ensembl:ENSP00000445401	psi-mi:grb10_human(display_long)|uniprotkb:GRB10(gene name)|psi-mi:GRB10(display_short)|uniprotkb:GRBIR(gene name synonym)|uniprotkb:KIAA0207(gene name synonym)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Insulin receptor-binding protein Grb-IR(gene name synonym)	psi-mi:rcan3_human(display_long)|uniprotkb:DSCR1L2(gene name synonym)|uniprotkb:Down syndrome candidate region 1-like protein 2(gene name synonym)|uniprotkb:Myocyte-enriched calcineurin-interacting protein 3(gene name synonym)|uniprotkb:Regulator of calcineurin 3(gene name synonym)|uniprotkb:RCAN3(gene name)|psi-mi:RCAN3(display_short)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700802|imex:IM-22632-677	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904738"(vascular associated smooth muscle cell migration)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035036|interpro:IPR035037|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q13322|rcsb pdb:1NRV|rcsb pdb:3HK0|reactome:R-HSA-1433557|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-9607240|reactome:R-HSA-9648895|ensembl:ENSG00000106070(gene)|ensembl:ENST00000398812(transcript)|ensembl:ENST00000401949(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010467"(gene expression)|refseq:XP_011513606.1|refseq:XP_011513614.1|refseq:XP_011513618.1|refseq:NP_001001549.1|refseq:NP_001001550.1|refseq:NP_001001555.1|refseq:NP_005302.3|refseq:XP_016867534.1|refseq:XP_016867535.1|refseq:XP_016867552.1|refseq:XP_016867553.1|refseq:XP_016867554.1|refseq:XP_016867555.1|refseq:XP_016867556.1|refseq:XP_016867557.1|dip:DIP-31657N|refseq:NM_001001550.2(identity)|entrezgene/locuslink:2887(identity)	refseq:NP_001238911.1|refseq:NP_001238912.1|refseq:NP_001238914.1|refseq:NP_038469.1|refseq:NP_001238906.1|refseq:NP_001238907.1|refseq:NP_001238908.1|refseq:NP_001238909.1|refseq:NP_001238910.1|refseq:NP_001238913.1|ensembl:ENSG00000117602(gene)|ensembl:ENST00000374395(transcript)|ensembl:ENST00000538532(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031013"(troponin I binding)|interpro:IPR006931(Calcipressin)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034923|interpro:IPR035979|refseq:NM_001251979.1(identity)|entrezgene/locuslink:11123(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:WBLkjS4iCC2gMTzR3izSFXGrBnk9606	rogid:GcjmPxKst3ISAOr1WMhJLrYq8JY9606	intact-crc:CBA2629759CFF7F6|rigid:RZk1QOuo+ApD3Yvs9QnA7TkBcmQ	false	sufficient binding region:59-594|protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZQ1	uniprotkb:Q92569	intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700818|imex:IM-22632-678	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N|refseq:NM_014991.4(identity)|entrezgene/locuslink:23001(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. tables S8 and S9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:7DEDDFE053591C32|rigid:spVanlkejP4ktZ7uCwuaIskEdFY	false	sufficient binding region:3246-3526|firefly luciferase protein tag:n-n	mutation disrupting interaction:383-383|mutation disrupting interaction:90-90|protein a tag:n-n|mutation decreasing interaction:383-383,90-90	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:Q15389-2	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-10692491|ensembl:ENSP00000297450	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:q15389-2(display_long)|uniprotkb:ANGPT1(gene name)|psi-mi:ANGPT1(display_short)|uniprotkb:KIAA0003(gene name synonym)|uniprotkb:Gly-269 del(isoform synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700838|imex:IM-22632-679	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	ensembl:ENSG00000154188(gene)|ensembl:ENST00000297450(transcript)|intact:EBI-2922365(isoform-parent)|entrezgene/locuslink:284(identity)|refseq:NM_001199859.1(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:5Upmh3KuCcINYHtPCexkVUarKPw9606	intact-crc:251261C5C5E70CC3|rigid:t8VXeUmQHfGBMJcztWFm8VlzdwU	false	firefly luciferase protein tag:n-n	sufficient binding region:255-401|protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05397	uniprotkb:Q9NP31	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700854|imex:IM-22632-680	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:0C37DA0FC5D17379|rigid:Nrlu/4OZupxaxYihwZVPX+DqP7w	false	sufficient binding region:393..393-1052..1052|protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05397	uniprotkb:Q92569	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700870|imex:IM-22632-681	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:F4C9C3A99DA1B128|rigid:m2bZ55O7kwAUUTOTtIuWnCtBjU4	false	sufficient binding region:393..393-1052..1052|protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29350-3	uniprotkb:Q05397	intact:EBI-7399369|ensembl:ENSP00000382376|intact:MINT-134096	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:p29350-3(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:PTP1C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700886|imex:IM-22632-682	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111679(gene)|ensembl:ENST00000399448(transcript)|intact:EBI-78260(isoform-parent)|uniprotkb:P29350-3(isoform-parent)|refseq:NM_080548.4(identity)|entrezgene/locuslink:5777(identity)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	-	comment:mint	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:dOlpiLWoBar/3ryQxTZss7nQqTs9606	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	intact-crc:B78A6BBA41BA2A39|rigid:ipDvtaGwayDkWR25O5iN15gbQ28	false	firefly luciferase protein tag:n-n	protein a tag:n-n|sufficient binding region:393..393-1052..1052	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05397	uniprotkb:P08631-2	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	intact:EBI-9834454|ensembl:ENSP00000429848|ensembl:ENSP00000486627	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:p08631-2(display_long)|uniprotkb:p59-HCK(isoform synonym)|uniprotkb:p59Hck(isoform synonym)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700902|imex:IM-22632-683	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	uniprotkb:P08631-2(isoform-parent)|intact:EBI-346340(isoform-parent)|ensembl:ENSG00000101336(gene)|ensembl:ENST00000520553(transcript)|ensembl:ENST00000629881(transcript)|entrezgene/locuslink:3055(identity)|refseq:NM_001172129.1(identity)	-	-	isoform-comment:Initiator Met-1 is removed. Contains a N-myristoyl glycine at position 2. Contains a S-palmitoyl cysteine at position 3.	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rogid:qSgfntp+jqdyi7qsc7u7UA7ylO09606	intact-crc:64DF16FD381C034E|rigid:ZfQA5qGMIi9RPwgRK7r0Ic34qPw	false	firefly luciferase protein tag:n-n|sufficient binding region:393..393-1052..1052	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05397	uniprotkb:Q14451	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	intact:EBI-970191|ensembl:ENSP00000310771|ensembl:ENSP00000377759|ensembl:ENSP00000377761|uniprotkb:B2RAV1|uniprotkb:B3KNL0|uniprotkb:B3KWP9|uniprotkb:B7WP75|uniprotkb:Q53YD3|uniprotkb:Q9Y220|uniprotkb:Q92568|uniprotkb:Q96DF9|intact:EBI-1257061|uniprotkb:J3KQM4	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:grb7_human(display_long)|uniprotkb:GRB7(gene name)|psi-mi:GRB7(display_short)|uniprotkb:GRB7 adapter protein(gene name synonym)|uniprotkb:Epidermal growth factor receptor GRB-7(gene name synonym)|uniprotkb:B47(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700918|imex:IM-22632-684	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	ensembl:ENSG00000141738(gene)|ensembl:ENST00000309156(transcript)|ensembl:ENST00000394209(transcript)|ensembl:ENST00000394211(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042995"(cell projection)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035032|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q14451|rcsb pdb:1MW4|rcsb pdb:1WGR|rcsb pdb:2L4K|rcsb pdb:2QMS|rcsb pdb:3PQZ|rcsb pdb:4WWQ|rcsb pdb:4X6S|rcsb pdb:5D0J|rcsb pdb:5EEL|rcsb pdb:5EEQ|rcsb pdb:5TYI|rcsb pdb:5U06|rcsb pdb:5U1Q|go:"GO:0042802"(identical protein binding)|reactome:R-HSA-1306955|reactome:R-HSA-186763|reactome:R-HSA-210993|reactome:R-HSA-8853659|reactome:R-HSA-9696273|reactome:R-HSA-1433557|refseq:NP_001025173.1|refseq:NP_001229371.1|refseq:NP_001229372.1|refseq:NP_005301.2|refseq:NP_001317136.1|dip:DIP-502N|entrezgene/locuslink:2886(identity)|refseq:NM_001030002.2(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rogid:XViWZjk5YwdZFTG3zs2aNdxeFVQ9606	intact-crc:2BF201E341C0A54F|rigid:nJTODhiyHVFKZAo2ndT6Ea3Yjsg	false	firefly luciferase protein tag:n-n|sufficient binding region:393..393-1052..1052	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:Q96A09	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-752030|ensembl:ENSP00000289166	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:tet5b_human(display_long)|uniprotkb:TENT5B(gene name)|psi-mi:TENT5B(display_short)|uniprotkb:FAM46B(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700934|imex:IM-22632-685	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	refseq:NP_443175.2|ensembl:ENSG00000158246(gene)|ensembl:ENST00000289166(transcript)|go:"GO:0048255"(mRNA stabilization)|go:"GO:1990817"(RNA adenylyltransferase activity)|interpro:IPR012937(Protein of unknown function DUF1693)|entrezgene/locuslink:115572(identity)|refseq:NM_052943.3(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:hcI1m66Kt1B5RS3kqXhFmu0lNrg9606	intact-crc:880D654C69E48DA7|rigid:y9rQGdkicQ8hFsiLKnWIr3y2iZ8	false	protein a tag:n-n	firefly luciferase protein tag:n-n|sufficient binding region:2-425	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TE12	uniprotkb:P62993	intact:EBI-10692065|uniprotkb:Q5VWG4|uniprotkb:Q0VDB5|uniprotkb:B3KXP6|uniprotkb:Q8TE11|ensembl:ENSP00000294816|ensembl:ENSP00000340226|ensembl:ENSP00000356868	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:lmx1a_human(display_long)|uniprotkb:LMX1A(gene name)|psi-mi:LMX1A(display_short)|uniprotkb:LIM/homeobox protein 1.1(gene name synonym)|uniprotkb:LIM/homeobox protein LMX1A(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700950|imex:IM-22632-686	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001167540.1|refseq:NP_796372.1|go:"GO:0046872"(metal ion binding)|go:"GO:0050808"(synapse organization)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR042688|ensembl:ENSG00000162761(gene)|ensembl:ENST00000294816(transcript)|ensembl:ENST00000342310(transcript)|ensembl:ENST00000367893(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021549"(cerebellum development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0042048"(olfactory behavior)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|entrezgene/locuslink:4009(identity)|refseq:XM_006711319.1(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	figure legend:Suppl. tables S8 and S9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:1Lm6PRjM5McmrHXC9GVW9zlWvDg9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:739A0FF9C6CD3E62|rigid:f3Z6f/LfZJFnQXE9fhnRB2QXqRk	false	firefly luciferase protein tag:n-n|sufficient binding region:283-382	mutation disrupting interaction:86-86|protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TAK6	uniprotkb:P07947	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700968|imex:IM-22632-687	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439|refseq:NM_005433.3(identity)|entrezgene/locuslink:7525(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	intact-crc:84F1A0B2634FC392|rigid:dgNIcYQENPkBykm+lSHws4I6Oio	false	firefly luciferase protein tag:n-n|sufficient binding region:17-271	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TAK6	uniprotkb:P08631-2	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	intact:EBI-9834454|ensembl:ENSP00000429848|ensembl:ENSP00000486627	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:p08631-2(display_long)|uniprotkb:p59-HCK(isoform synonym)|uniprotkb:p59Hck(isoform synonym)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10700984|imex:IM-22632-688	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	uniprotkb:P08631-2(isoform-parent)|intact:EBI-346340(isoform-parent)|ensembl:ENSG00000101336(gene)|ensembl:ENST00000520553(transcript)|ensembl:ENST00000629881(transcript)|entrezgene/locuslink:3055(identity)|refseq:NM_001172129.1(identity)	-	-	isoform-comment:Initiator Met-1 is removed. Contains a N-myristoyl glycine at position 2. Contains a S-palmitoyl cysteine at position 3.	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	rogid:qSgfntp+jqdyi7qsc7u7UA7ylO09606	intact-crc:510B1E48B71A07FC|rigid:YQAeJdSPVk5bACbPibOzufXNRtc	false	sufficient binding region:17-271|firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TAK6	uniprotkb:Q14451	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	intact:EBI-970191|ensembl:ENSP00000310771|ensembl:ENSP00000377759|ensembl:ENSP00000377761|uniprotkb:B2RAV1|uniprotkb:B3KNL0|uniprotkb:B3KWP9|uniprotkb:B7WP75|uniprotkb:Q53YD3|uniprotkb:Q9Y220|uniprotkb:Q92568|uniprotkb:Q96DF9|intact:EBI-1257061|uniprotkb:J3KQM4	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:grb7_human(display_long)|uniprotkb:GRB7(gene name)|psi-mi:GRB7(display_short)|uniprotkb:GRB7 adapter protein(gene name synonym)|uniprotkb:Epidermal growth factor receptor GRB-7(gene name synonym)|uniprotkb:B47(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701000|imex:IM-22632-689	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	ensembl:ENSG00000141738(gene)|ensembl:ENST00000309156(transcript)|ensembl:ENST00000394209(transcript)|ensembl:ENST00000394211(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042995"(cell projection)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035032|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q14451|rcsb pdb:1MW4|rcsb pdb:1WGR|rcsb pdb:2L4K|rcsb pdb:2QMS|rcsb pdb:3PQZ|rcsb pdb:4WWQ|rcsb pdb:4X6S|rcsb pdb:5D0J|rcsb pdb:5EEL|rcsb pdb:5EEQ|rcsb pdb:5TYI|rcsb pdb:5U06|rcsb pdb:5U1Q|go:"GO:0042802"(identical protein binding)|reactome:R-HSA-1306955|reactome:R-HSA-186763|reactome:R-HSA-210993|reactome:R-HSA-8853659|reactome:R-HSA-9696273|reactome:R-HSA-1433557|refseq:NP_001025173.1|refseq:NP_001229371.1|refseq:NP_001229372.1|refseq:NP_005301.2|refseq:NP_001317136.1|dip:DIP-502N|entrezgene/locuslink:2886(identity)|refseq:NM_001030002.2(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	rogid:XViWZjk5YwdZFTG3zs2aNdxeFVQ9606	intact-crc:E676A9F47420716E|rigid:GebKMHt5elcU4o4cYn+tkSqg0fc	false	firefly luciferase protein tag:n-n|sufficient binding region:17-271	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TAK6	uniprotkb:Q92569	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701016|imex:IM-22632-690	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:FE23B2DBDF43CF2A|rigid:uklMzAGeiMzEZqjSar17I3AbQCE	false	sufficient binding region:17-271|firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q66PJ3-4	uniprotkb:P62993	intact:EBI-5280499	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:q66pj3-4(display_long)|uniprotkb:Splicing factor SRrp37(gene name synonym)|uniprotkb:ARL6IP4(gene name)|psi-mi:ARL6IP4(display_short)|uniprotkb:HSP-975(gene name synonym)|uniprotkb:HSVI-binding protein(gene name synonym)|uniprotkb:SR-15(gene name synonym)|uniprotkb:SRp25(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701032|imex:IM-22632-691	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2683099(isoform-parent)|uniprotkb:Q66PJ3-4(isoform-parent)|entrezgene/locuslink:51329(identity)|refseq:NM_001002252.2(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:XZT/eX9V6PNVyIyUg7RvZpH0Ydg9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:AE6CC2AF4FE0E618|rigid:hw+8a5B8+s66k/rniQ0tqk4KyY4	false	sufficient binding region:185-399|firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q5SXH7-1	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-26412802	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:q5sxh7-1(display_long)|uniprotkb:PLEKHS1(gene name)|psi-mi:PLEKHS1(display_short)|uniprotkb:C10orf81(gene name synonym)|uniprotkb:Epididymis luminal protein 185(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701048|imex:IM-22632-692	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	intact:EBI-10691507(isoform-parent)|entrezgene/locuslink:79949(identity)|refseq:XM_005270162.2(identity)	-	-	-	figure legend:Suppl. tables S8 and S9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2020/10/22	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:8OuCSDcvw9rtC0JZC596NetxIKA9606	intact-crc:9C3BB611A7ED4115|rigid:NnbEecG1Kp3JPn2xdnbmM2cu0ZU	false	mutation disrupting interaction:86-86|protein a tag:n-n	firefly luciferase protein tag:n-n|sufficient binding region:181-462	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5SXH7-1	uniprotkb:Q92569	intact:EBI-26412802	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:q5sxh7-1(display_long)|uniprotkb:PLEKHS1(gene name)|psi-mi:PLEKHS1(display_short)|uniprotkb:C10orf81(gene name synonym)|uniprotkb:Epididymis luminal protein 185(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701066|imex:IM-22632-693	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-10691507(isoform-parent)|entrezgene/locuslink:79949(identity)|refseq:XM_005270162.2(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2020/10/22	rogid:8OuCSDcvw9rtC0JZC596NetxIKA9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:BC8E233F071A1776|rigid:/gCqH01nPA8E1ZE/l/NkTtgRxWo	false	firefly luciferase protein tag:n-n|sufficient binding region:181-462	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07869	uniprotkb:P62993	intact:EBI-78615|uniprotkb:Q16241|uniprotkb:Q92486|uniprotkb:Q92689|uniprotkb:Q9Y3N1|ensembl:ENSP00000262735|ensembl:ENSP00000385246|ensembl:ENSP00000385523|uniprotkb:Q6I9S0|uniprotkb:B0G0X3	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:ppara_human(display_long)|uniprotkb:PPARA(gene name)|psi-mi:PPARA(display_short)|uniprotkb:NR1C1(gene name synonym)|uniprotkb:PPAR(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group C member 1(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701082|imex:IM-22632-694	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_005261712.1|refseq:XP_005261713.1|ensembl:ENSG00000186951(gene)|ensembl:ENST00000262735(transcript)|ensembl:ENST00000402126(transcript)|ensembl:ENST00000407236(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008544"(epidermis development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010876"(lipid localization)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033993"(response to lipid)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070166"(enamel mineralization)|go:"GO:0045471"(response to ethanol)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|rcsb pdb:1I7G|go:"GO:0097371"(MDM2/MDM4 family protein binding)|rcsb pdb:1K7L|rcsb pdb:1KKQ|rcsb pdb:2NPA|rcsb pdb:2P54|rcsb pdb:2REW|rcsb pdb:2ZNN|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:2000191"(regulation of fatty acid transport)|go:"GO:2000272"(negative regulation of signaling receptor activity)|rcsb pdb:3ET1|rcsb pdb:3FEI|rcsb pdb:3G8I|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003074(Peroxisome proliferator-activated receptor)|interpro:IPR003076(Peroxisome proliferator-activated receptor, alpha)|rcsb pdb:3KDT|interpro:IPR013088(Zinc finger, NHR/GATA-type)|rcsb pdb:3KDU|interpro:IPR035500|mint:Q07869|rcsb pdb:3SP6|rcsb pdb:3VI8|rcsb pdb:4BCR|rcsb pdb:4CI4|reactome:R-HSA-1989781|rcsb pdb:5AZT|reactome:R-HSA-2151201|reactome:R-HSA-2426168|rcsb pdb:5HYK|rcsb pdb:6KAX|reactome:R-HSA-381340|rcsb pdb:6KAY|rcsb pdb:6KAZ|reactome:R-HSA-383280|rcsb pdb:6KB0|reactome:R-HSA-400206|rcsb pdb:6KB1|rcsb pdb:6KB2|rcsb pdb:6KB3|rcsb pdb:6KB4|rcsb pdb:6KB5|reactome:R-HSA-400253|reactome:R-HSA-4090294|rcsb pdb:6KB6|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:6KB7|rcsb pdb:6KB8|rcsb pdb:6KB9|rcsb pdb:6KBA|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6KYP|rcsb pdb:6L36|rcsb pdb:6L37|rcsb pdb:6L38|rcsb pdb:6L96|rcsb pdb:6LX4|rcsb pdb:6LX5|rcsb pdb:6LX6|rcsb pdb:6LX7|rcsb pdb:6LX8|rcsb pdb:6LX9|rcsb pdb:6LXA|rcsb pdb:6LXB|rcsb pdb:6LXC|rcsb pdb:7BPY|rcsb pdb:7BPZ|rcsb pdb:7BQ0|rcsb pdb:7BQ1|rcsb pdb:7BQ2|rcsb pdb:7BQ3|rcsb pdb:7BQ4|rcsb pdb:7C6Q|reactome:R-HSA-1368082|reactome:R-HSA-1368108|refseq:NP_001001928.1|refseq:NP_005027.2|refseq:XP_011528541.1|refseq:XP_011528542.1|refseq:XP_011528543.1|refseq:XP_011528544.1|refseq:XP_011528545.1|refseq:XP_006724332.1|refseq:XP_006724333.1|dip:DIP-241N|refseq:XM_006724271.1(identity)|entrezgene/locuslink:5465(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	figure legend:Suppl. tables S8 and S9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:0ZZ5eL0cNC8OgOvd8spQ5ypBvAo9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:DF72A183E5126646|rigid:zTvRdTBXirQk9l7jXtSGw+bNfpM	false	sufficient binding region:1-237|firefly luciferase protein tag:n-n	mutation disrupting interaction:86-86|protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:Q9Y575	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-2875625|ensembl:ENSP00000263634|ensembl:ENSP00000385085|uniprotkb:Q53TN8|uniprotkb:Q53TN0|uniprotkb:B3KPA3|uniprotkb:Q9NVZ2|uniprotkb:D6W5B4|uniprotkb:D6W5B5|uniprotkb:G8JLA9|uniprotkb:Q2TAI4	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:asb3_human(display_long)|uniprotkb:ASB3(gene name)|psi-mi:ASB3(display_short)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701100|imex:IM-22632-695	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	go:"GO:0030315"(T-tubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0055117"(regulation of cardiac muscle contraction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036036|interpro:IPR036770|interpro:IPR037329|mint:Q9Y575|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000115239(gene)|ensembl:ENST00000263634(transcript)|ensembl:ENST00000406625(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|refseq:NP_001188894.1|refseq:NP_057199.1|refseq:NP_665862.1|refseq:NP_001157637.1|refseq:NM_016115.4(identity)|entrezgene/locuslink:51130(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:gIMKRtUzf90UdaMhaSwEmesN+KE9606	intact-crc:2E5E46E148B6ADA1|rigid:ByIH+zvsNIh3dHDQU9Mo6PRF7kw	false	protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y3I0	uniprotkb:Q9UKG1	intact:EBI-2107208|uniprotkb:Q6IAI0|uniprotkb:Q9BWL4|uniprotkb:Q9NTH1|uniprotkb:Q9P037|uniprotkb:Q9P0J3|uniprotkb:B2R6A8|intact:EBI-4399544|ensembl:ENSP00000216038	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:rtcb_human(display_long)|uniprotkb:3'-phosphate/5'-hydroxy nucleic acid ligase(gene name synonym)|uniprotkb:C22orf28(gene name synonym)|uniprotkb:HSPC117(orf name)|uniprotkb:RTCB(gene name)|psi-mi:RTCB(display_short)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701114|imex:IM-22632-696	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055121.1|dip:DIP-46750N|ensembl:ENSG00000100220(gene)|ensembl:ENST00000216038(transcript)|go:"GO:0000971"(tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate)|go:"GO:0003723"(RNA binding)|go:"GO:0003972"("RNA ligase (ATP) activity")|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0017166"(vinculin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0072669"(tRNA-splicing ligase complex)|interpro:IPR001233(Protein of unknown function UPF0027)|interpro:IPR027513|interpro:IPR036025|mint:Q9Y3I0|reactome:R-HSA-6784531|entrezgene/locuslink:51493(identity)|refseq:NM_014306.4(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:URuCEq/DIn6DgR3jOb5fwnpDVXE9606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:B77657AA08372998|rigid:cX6dThTWLBA6ZO4DmhaT9CvB0Dc	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UN19	uniprotkb:O95704	intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602	intact:EBI-286427|uniprotkb:Q9NYX6|uniprotkb:Q9NYX7|uniprotkb:Q08AG4|uniprotkb:Q9NYX8|uniprotkb:B3KQN9|uniprotkb:Q96Q18|uniprotkb:Q9BYD4|ensembl:ENSP00000350171	psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name)	psi-mi:apbb3_human(display_long)|uniprotkb:Protein Fe65-like 2(gene name synonym)|uniprotkb:APBB3(gene name)|psi-mi:APBB3(display_short)|uniprotkb:FE65L2(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701128|imex:IM-22632-697	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695|entrezgene/locuslink:27071(identity)|refseq:NM_014395.2(identity)	refseq:NP_006042.3|refseq:NP_573418.2|refseq:NP_573419.2|refseq:NP_573420.2|ensembl:ENSG00000113108(gene)|ensembl:ENST00000357560(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036020|interpro:IPR039576|rcsb pdb:2DYQ|rcsb pdb:2YSC|entrezgene/locuslink:10307(identity)|refseq:NM_133173.2(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:YYI49xKbndaB1MfL/QEovp2BF009606	rogid:U1jEo7ZPG53cA/BcJs/BMGo/vWE9606	intact-crc:F6C45D9A11B33C93|rigid:Uy5KPDULZ4bzUcuYizIo41kbReA	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UF11-4	uniprotkb:Q9NP31	intact:EBI-9089825|ensembl:ENSP00000227214|ensembl:ENSP00000442616	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:q9uf11-4(display_long)|uniprotkb:EVT1(gene name synonym)|uniprotkb:Evectin-1(gene name synonym)|uniprotkb:KPL1(gene name synonym)|uniprotkb:PH domain-containing protein in retina 1(gene name synonym)|uniprotkb:PHR1(gene name synonym)|uniprotkb:PHRET1(gene name synonym)|uniprotkb:Pleckstrin homology domain retinal protein 1(gene name synonym)|uniprotkb:PLEKHB1(gene name)|psi-mi:PLEKHB1(display_short)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701142|imex:IM-22632-698	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6447271(isoform-parent)|ensembl:ENSG00000021300(gene)|ensembl:ENST00000227214(transcript)|ensembl:ENST00000535129(transcript)|entrezgene/locuslink:58473(identity)|refseq:NM_001130035.1(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:5RmF2rJLHJT3yM6ZP4+m7unTGNs9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:56CE4622C1467F02|rigid:OG0e/at7nc4V8Xy07NpI6744KlI	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NPB6-2	uniprotkb:P62993	intact:EBI-10693102|ensembl:ENSP00000392388	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:q9npb6-2(display_long)|uniprotkb:PARD6A(gene name)|psi-mi:PARD6A(display_short)|uniprotkb:PAR6A(gene name synonym)|uniprotkb:PAR6C(gene name synonym)|uniprotkb:Tax interaction protein 40(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701156|imex:IM-22632-699	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-81876(isoform-parent)|ensembl:ENSG00000102981(gene)|ensembl:ENST00000458121(transcript)|uniprotkb:Q9NPB6-2(isoform-parent)|refseq:NM_001037281.1(identity)|entrezgene/locuslink:50855(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:hLX1kt+/BGPnr4HvpWndVysxrTU9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:BB26AAE7A9F803C9|rigid:LuRVnZJWGHvsq8dtCFq7HwULj8g	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q9NP31	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701170|imex:IM-22632-700	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	agonist:"ABL2  (P42684)"|figure legend:Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:C593826C8AA7A462|rigid:9IhtipCdg1OD6tsl6/DeyNKPvC0	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27986-2	uniprotkb:Q9NP31	intact:EBI-9090282|ensembl:ENSP00000338554	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701185|imex:IM-22632-701	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:747489C12557D2C5|rigid:08gAcWchF1amVgDcetEj9So911A	false	protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:Q14847	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-742828|uniprotkb:Q96ED2|uniprotkb:Q96IG0|ensembl:ENSP00000325240|ensembl:ENSP00000392853|uniprotkb:B4DGQ0	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:lasp1_human(display_long)|uniprotkb:Metastatic lymph node gene 50 protein(gene name synonym)|uniprotkb:LASP1(gene name)|psi-mi:LASP1(display_short)|uniprotkb:MLN50(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701199|imex:IM-22632-702	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	refseq:NP_006139.1|refseq:NP_001258537.1|ensembl:ENSG00000002834(gene)|ensembl:ENST00000318008(transcript)|ensembl:ENST00000435347(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006811"(ion transport)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|interpro:IPR000900(Nebulin 35 residue motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR035630|interpro:IPR036028|mint:Q14847|rcsb pdb:3I35|refseq:NM_006148.3(identity)|entrezgene/locuslink:3927(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:Oa+FdJXeQhahYTqVrHYk6yBrUWI9606	intact-crc:15C4834C4F9A7AE5|rigid:GDXWZNvzISDuqMwizNwXxEKxYHI	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TEW6	uniprotkb:Q9BSQ5	intact:EBI-6918542|ensembl:ENSP00000344277|ensembl:ENSP00000455128|uniprotkb:O75209|uniprotkb:Q9BTP2|uniprotkb:Q9NVV3	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	psi-mi:dok4_human(display_long)|uniprotkb:DOK4(gene name)|psi-mi:DOK4(display_short)|uniprotkb:Downstream of tyrosine kinase 4(gene name synonym)|uniprotkb:Insulin receptor substrate 5(gene name synonym)	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701213|imex:IM-22632-703	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000125170(gene)|ensembl:ENST00000340099(transcript)|ensembl:ENST00000569548(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0043410"(positive regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_060580.2|refseq:XP_005256100.1|entrezgene/locuslink:55715(identity)|refseq:NM_018110.3(identity)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N|refseq:NM_031443.3(identity)|entrezgene/locuslink:83605(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:Xc4aPsHtdQKj02Q5cqqgw29pSS09606	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	intact-crc:7A3E2EE94EF1A7EE|rigid:stzbqPSyL/LLqKnKP/O4C2M5pRA	false	protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96R05	uniprotkb:Q92569	intact:EBI-2856326|uniprotkb:B2R517|uniprotkb:Q5SWJ4|ensembl:ENSP00000294435	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:ret7_human(display_long)|uniprotkb:RBP7(gene name)|psi-mi:RBP7(display_short)|uniprotkb:Cellular retinoic acid-binding protein 4(gene name synonym)|uniprotkb:Cellular retinoic acid-binding protein IV(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701227|imex:IM-22632-704	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443192.1|interpro:IPR031259|rcsb pdb:1LPJ|rcsb pdb:6AT8|rcsb pdb:6E6K|ensembl:ENSG00000162444(gene)|ensembl:ENST00000294435(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016918"(retinal binding)|go:"GO:0019841"(retinol binding)|interpro:IPR000463(Cytosolic fatty-acid binding)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|entrezgene/locuslink:116362(identity)|refseq:NM_052960.2(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:75axWxV5mnxExd1avjdlOUK4o2E9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:5EAA707C7B8AE99F|rigid:GQJdy08m0L8IK7bXQLHqKjbuRLo	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BSQ5	uniprotkb:Q96N03	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	intact:EBI-948213|uniprotkb:Q5JWZ4|uniprotkb:Q5JWZ5|uniprotkb:Q8ND45|uniprotkb:Q9BR37|uniprotkb:E1P5V7|ensembl:ENSP00000362560	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:vtm2l_human(display_long)|uniprotkb:C20orf102(gene name synonym)|uniprotkb:VSTM2L(gene name)|psi-mi:VSTM2L(display_short)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701241|imex:IM-22632-705	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N|refseq:NM_031443.3(identity)|entrezgene/locuslink:83605(identity)	refseq:NP_542174.1|ensembl:ENSG00000132821(gene)|ensembl:ENST00000373461(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0030424"(axon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR027115|interpro:IPR036179|refseq:NM_080607.2(identity)|entrezgene/locuslink:128434(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	rogid:CMZ06pQwq1ob76PkF0ZdxdLJwwY9606	intact-crc:83874C21AD853FA7|rigid:OW4hbb06Irg1xw9KD15p/94GzrU	false	protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96IP4	uniprotkb:P43405	intact:EBI-954084|uniprotkb:Q5TF86|uniprotkb:Q8NFZ9|uniprotkb:Q9BW32|uniprotkb:Q9NXV5|uniprotkb:A8K7U4|ensembl:ENSP00000318298	intact:EBI-78302|ensembl:ENSP00000364898|ensembl:ENSP00000364907	psi-mi:tet5a_human(display_long)|uniprotkb:TENT5A(gene name)|psi-mi:TENT5A(display_short)|uniprotkb:C6orf37(gene name synonym)|uniprotkb:FAM46A(gene name synonym)|uniprotkb:HBV X-transactivated gene 11 protein(gene name synonym)|uniprotkb:HBV XAg-transactivated protein 11(gene name synonym)|uniprotkb:XTP11(gene name synonym)	psi-mi:ksyk_human(display_long)|uniprotkb:SYK(gene name)|psi-mi:SYK(display_short)|uniprotkb:Spleen tyrosine kinase(gene name synonym)|uniprotkb:p72-Syk(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701255|imex:IM-22632-706	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060103.2|ensembl:ENSG00000112773(gene)|ensembl:ENST00000320172(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0048255"(mRNA stabilization)|go:"GO:1990817"(RNA adenylyltransferase activity)|interpro:IPR012937(Protein of unknown function DUF1693)|entrezgene/locuslink:55603(identity)|refseq:NM_017633.2(identity)	refseq:NP_001128524.1|refseq:NP_001167638.1|refseq:NP_001167639.1|refseq:NP_003168.2|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043313"(regulation of neutrophil degranulation)|go:"GO:0043366"(beta selection)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090237"(regulation of arachidonic acid secretion)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43405|rcsb pdb:1A81|rcsb pdb:1CSY|rcsb pdb:1CSZ|rcsb pdb:1XBA|rcsb pdb:1XBB|rcsb pdb:1XBC|rcsb pdb:3BUW|rcsb pdb:3EMG|rcsb pdb:3FQE|rcsb pdb:3FQH|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019815"(B cell receptor complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0032009"(early phagosome)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032752"(positive regulation of interleukin-3 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032928"(regulation of superoxide anion generation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0016170"(interleukin-15 receptor binding)|rcsb pdb:3FQS|rcsb pdb:3SRV|rcsb pdb:3TUB|rcsb pdb:3TUC|rcsb pdb:3TUD|rcsb pdb:3VF8|rcsb pdb:3VF9|rcsb pdb:4DFL|rcsb pdb:4DFN|rcsb pdb:4F4P|rcsb pdb:4FL1|rcsb pdb:4FL2|rcsb pdb:4FL3|rcsb pdb:4FYN|rcsb pdb:4FYO|rcsb pdb:4FZ6|rcsb pdb:4FZ7|rcsb pdb:4GFG|rcsb pdb:4I0R|ensembl:ENSG00000165025(gene)|ensembl:ENST00000375746(transcript)|ensembl:ENST00000375754(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002554"(serotonin secretion by platelet)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|rcsb pdb:4I0S|rcsb pdb:4I0T|rcsb pdb:4PUZ|rcsb pdb:4PV0|rcsb pdb:4PX6|rcsb pdb:4RSS|rcsb pdb:4RX7|rcsb pdb:4RX8|rcsb pdb:4RX9|rcsb pdb:4WNM|rcsb pdb:4XG2|rcsb pdb:4XG3|rcsb pdb:5TIU|rcsb pdb:5TR6|rcsb pdb:5TT7|rcsb pdb:5Y5T|rcsb pdb:5Y5U|rcsb pdb:6HM6|rcsb pdb:6HM7|rcsb pdb:6SSB|rcsb pdb:6VOV|rcsb pdb:6ZC0|rcsb pdb:6ZCP|rcsb pdb:6ZCQ|rcsb pdb:6ZCR|rcsb pdb:6ZCS|rcsb pdb:6ZCU|rcsb pdb:6ZCX|rcsb pdb:6ZCY|rcsb pdb:4XG4|reactome:R-HSA-114604|reactome:R-HSA-2029481|reactome:R-HSA-2029482|rcsb pdb:4XG7|rcsb pdb:4XG8|rcsb pdb:4XG9|rcsb pdb:4YJO|rcsb pdb:4YJP|rcsb pdb:4YJQ|rcsb pdb:4YJR|rcsb pdb:4YJS|rcsb pdb:4YJT|rcsb pdb:4YJU|rcsb pdb:4YJV|rcsb pdb:5C26|rcsb pdb:5C27|rcsb pdb:5CXH|rcsb pdb:5CXZ|rcsb pdb:5CY3|rcsb pdb:5GHV|rcsb pdb:5LMA|rcsb pdb:4XG6|rcsb pdb:5LMB|rcsb pdb:5T68|refseq:XP_011517248.1|refseq:XP_005252204.1|reactome:R-HSA-2029485|reactome:R-HSA-2424491|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9020558|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374|reactome:R-HSA-983695|dip:DIP-253N|entrezgene/locuslink:6850(identity)|refseq:NM_001174167.2(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:RoYW7NusMegWdnScxOvz6GI6Kjo9606	rogid:SAOtCMFKG07Wej573EklHjusYVA9606	intact-crc:09EC05740B9232D0|rigid:NntW2da6K1qNXXzpu8RKR7tIL7M	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96IP4	uniprotkb:Q9NP31	intact:EBI-954084|uniprotkb:Q5TF86|uniprotkb:Q8NFZ9|uniprotkb:Q9BW32|uniprotkb:Q9NXV5|uniprotkb:A8K7U4|ensembl:ENSP00000318298	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:tet5a_human(display_long)|uniprotkb:TENT5A(gene name)|psi-mi:TENT5A(display_short)|uniprotkb:C6orf37(gene name synonym)|uniprotkb:FAM46A(gene name synonym)|uniprotkb:HBV X-transactivated gene 11 protein(gene name synonym)|uniprotkb:HBV XAg-transactivated protein 11(gene name synonym)|uniprotkb:XTP11(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701269|imex:IM-22632-707	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060103.2|ensembl:ENSG00000112773(gene)|ensembl:ENST00000320172(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0048255"(mRNA stabilization)|go:"GO:1990817"(RNA adenylyltransferase activity)|interpro:IPR012937(Protein of unknown function DUF1693)|entrezgene/locuslink:55603(identity)|refseq:NM_017633.2(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:RoYW7NusMegWdnScxOvz6GI6Kjo9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:A245F03B96F1BACA|rigid:S/ydXptquYVA2toac2ye1abZYMc	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q96DX5	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-745641|uniprotkb:Q9NWS5|uniprotkb:Q9Y4T3|uniprotkb:A8K8A5|ensembl:ENSP00000369855|intact:EBI-2349899|uniprotkb:Q9BVF5	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:asb9_human(display_long)|uniprotkb:ASB9(gene name)|psi-mi:ASB9(display_short)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701283|imex:IM-22632-708	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_001026909.1|refseq:NP_001162003.1|refseq:NP_076992.1|ensembl:ENST00000380488(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045732"(positive regulation of protein catabolic process)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036036|interpro:IPR036770|interpro:IPR037333|mint:Q96DX5|rcsb pdb:3D9H|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:6V9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000102048(gene)|refseq:NP_001162002.1|refseq:XP_005274503.1|dip:DIP-52905N|entrezgene/locuslink:140462(identity)|refseq:NM_001031739.2(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:ptKNzNqGuV3MO9/nIT6RI+w/Jtk9606	intact-crc:A2346706056D9BFB|rigid:nxazHMoQanwtG5tUYyAW6f0pLUs	false	protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:O60237-2	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-10700351|ensembl:ENSP00000349206	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:o60237-2(display_long)|uniprotkb:PPP1R12B(gene name)|psi-mi:PPP1R12B(display_short)|uniprotkb:MYPT2(gene name synonym)|uniprotkb:Myosin phosphatase-targeting subunit 2(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701297|imex:IM-22632-709	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	ensembl:ENSG00000077157(gene)|ensembl:ENST00000356764(transcript)|intact:EBI-2558026(isoform-parent)|uniprotkb:O60237-2(isoform-parent)|entrezgene/locuslink:4660(identity)|refseq:NM_001167858.1(identity)	-	-	isoform-comment:Produced by alternative splicing of isoform 1. No experimental confirmation available.	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:vroZRva3UhIrZLt/UaNvIhLoZWI9606	intact-crc:E3E400ECEF290CDE|rigid:GZpxdvbsipkSQ7HzykoenNWDdBs	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:P08631-2	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-9834454|ensembl:ENSP00000429848|ensembl:ENSP00000486627	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:p08631-2(display_long)|uniprotkb:p59-HCK(isoform synonym)|uniprotkb:p59Hck(isoform synonym)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701311|imex:IM-22632-710	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	uniprotkb:P08631-2(isoform-parent)|intact:EBI-346340(isoform-parent)|ensembl:ENSG00000101336(gene)|ensembl:ENST00000520553(transcript)|ensembl:ENST00000629881(transcript)|entrezgene/locuslink:3055(identity)|refseq:NM_001172129.1(identity)	-	-	isoform-comment:Initiator Met-1 is removed. Contains a N-myristoyl glycine at position 2. Contains a S-palmitoyl cysteine at position 3.	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:qSgfntp+jqdyi7qsc7u7UA7ylO09606	intact-crc:B644CD453D2D1011|rigid:qfJOe/FsOciLbpYBqVn5AZMH/88	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:P22681	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701325|imex:IM-22632-711	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:3189C2C65FBB79BF|rigid:H45MGP2sseKC/dza30HFhS26Qqg	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35568	uniprotkb:Q92569	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701339|imex:IM-22632-712	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772|refseq:NM_005544.2(identity)|entrezgene/locuslink:3667(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:A3C3D2167C12988C|rigid:JTCBBkGf9heSVjXJrI8dklyOaoA	false	protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53672	uniprotkb:Q92569	intact:EBI-750444|uniprotkb:Q9Y562|uniprotkb:Q4ZFX0|ensembl:ENSP00000295728|ensembl:ENSP00000375946	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:crba2_human(display_long)|uniprotkb:Beta-A2 crystallin(gene name synonym)|uniprotkb:CRYBA2(gene name)|psi-mi:CRYBA2(display_short)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701353|imex:IM-22632-713	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476434.1|refseq:NP_476435.1|ensembl:ENSG00000163499(gene)|ensembl:ENST00000295728(transcript)|ensembl:ENST00000392096(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|mint:P53672|entrezgene/locuslink:1412(identity)|refseq:NM_057094.1(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:/WkdaQ4LTxa9mpIiOwVuhd375mE9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:59FC5FAADF887F99|rigid:QiwDJtJbxb1JQtZfon0yBo8GD+g	false	protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q8WXH5	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701367|imex:IM-22632-714	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	-	-	-	figure legend:Suppl. tables S8 and S9, fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	intact-crc:C151FD145ECFCAE6|rigid:HSH4BIaK53MwkzzXpWiE6XD6pw8	false	mutation disrupting interaction:86-86|protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WXH5	uniprotkb:O43559	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701383|imex:IM-22632-715	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	intact-crc:18D9148624A1BF88|rigid:SYCyk0/sOI62Rt87FHOtxHvsCT4	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96R05	uniprotkb:Q8WXH5	intact:EBI-2856326|uniprotkb:B2R517|uniprotkb:Q5SWJ4|ensembl:ENSP00000294435	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	psi-mi:ret7_human(display_long)|uniprotkb:RBP7(gene name)|psi-mi:RBP7(display_short)|uniprotkb:Cellular retinoic acid-binding protein 4(gene name synonym)|uniprotkb:Cellular retinoic acid-binding protein IV(gene name synonym)	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701397|imex:IM-22632-716	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443192.1|interpro:IPR031259|rcsb pdb:1LPJ|rcsb pdb:6AT8|rcsb pdb:6E6K|ensembl:ENSG00000162444(gene)|ensembl:ENST00000294435(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016918"(retinal binding)|go:"GO:0019841"(retinol binding)|interpro:IPR000463(Cytosolic fatty-acid binding)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|entrezgene/locuslink:116362(identity)|refseq:NM_052960.2(identity)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:75axWxV5mnxExd1avjdlOUK4o2E9606	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	intact-crc:3EE6E4A699518C37|rigid:xx2daNyRU+x+ug9JMXiLcab3ajI	false	protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXM7	uniprotkb:Q8WXH5	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701411|imex:IM-22632-717	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N|entrezgene/locuslink:65018(identity)|refseq:NM_032409.2(identity)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	intact-crc:B72CCD36F6B85786|rigid:jeSxNnYq9fpGbm0LS1OKSzjQLqs	false	protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WVJ9	uniprotkb:Q9BSQ5	intact:EBI-1797313|uniprotkb:Q3SYL6|ensembl:ENSP00000405176|ensembl:ENSP00000482581|ensembl:ENSP00000500440|ensembl:ENSP00000500609	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	psi-mi:twst2_human(display_long)|uniprotkb:Dermis-expressed protein 1(gene name synonym)|uniprotkb:TWIST2(gene name)|psi-mi:TWIST2(display_short)|uniprotkb:DERMO1(gene name synonym)|uniprotkb:BHLHA39(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 39(gene name synonym)	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701425|imex:IM-22632-718	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258822.1|refseq:NP_476527.1|ensembl:ENSG00000233608(gene)|ensembl:ENSG00000288335(gene)|ensembl:ENST00000448943(transcript)|ensembl:ENST00000612363(transcript)|ensembl:ENST00000671947(transcript)|ensembl:ENST00000673387(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032502"(developmental process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015789(Twist)|interpro:IPR036638|reactome:R-HSA-8878166|entrezgene/locuslink:117581(identity)|refseq:NM_057179.2(identity)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N|refseq:NM_031443.3(identity)|entrezgene/locuslink:83605(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:IYIpMXYdrqllQqS+Ftz+P0xtk789606	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	intact-crc:D35DB642093FFC34|rigid:q28n3k04QLjqaBiKQ3h7blFJNmI	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TBZ3	uniprotkb:Q9UN19	intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0	intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602	psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym)	psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701439|imex:IM-22632-719	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1|entrezgene/locuslink:91833(identity)|refseq:NM_144574.3(identity)	refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695|entrezgene/locuslink:27071(identity)|refseq:NM_014395.2(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606	rogid:YYI49xKbndaB1MfL/QEovp2BF009606	intact-crc:03A60F00D5D6CAD9|rigid:45/uOV2AqDMtDjF1OJMOxrueL00	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TAL5	uniprotkb:Q5R372-2	intact:EBI-10694291|ensembl:ENSP00000288462|ensembl:ENSP00000363280	intact:EBI-10692254|ensembl:ENSP00000350027	psi-mi:ci043_human(display_long)|uniprotkb:C9orf43(gene name)|psi-mi:C9orf43(display_short)	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701453|imex:IM-22632-720	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001265558.1|refseq:NP_689999.1|ensembl:ENSG00000157653(gene)|ensembl:ENST00000288462(transcript)|ensembl:ENST00000374165(transcript)|interpro:IPR029134|mint:Q8TAL5|refseq:NM_001278629.1(identity)|entrezgene/locuslink:257169(identity)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:LGnLEmC1sPfnq+qr2b3M7cEccek9606	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	intact-crc:FD0507FDFB6CF643|rigid:eJUhhZkMvQnZauEbWk6gp5iT7IQ	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UPY8	uniprotkb:Q8NEU8	intact:EBI-726739|uniprotkb:O00265|uniprotkb:Q6FI15|uniprotkb:Q9BZP7|uniprotkb:Q9BZP8|uniprotkb:B7WPK5|uniprotkb:Q6FHB0|ensembl:ENSP00000233121	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	psi-mi:mare3_human(display_long)|uniprotkb:End-binding protein 3(gene name synonym)|uniprotkb:EB1 protein family member 3(gene name synonym)|uniprotkb:RP3(gene name synonym)|uniprotkb:MAPRE3(gene name)|psi-mi:MAPRE3(display_short)	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701467|imex:IM-22632-721	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036458.2|refseq:XP_016859086.1|refseq:NP_001289979.1|refseq:XP_006712030.1|refseq:XP_011531002.1|dip:DIP-56069N|ensembl:ENSG00000084764(gene)|ensembl:ENST00000233121(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042802"(identical protein binding)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:1903033"(positive regulation of microtubule plus-end binding)|go:"GO:1904825"(protein localization to microtubule plus-end)|go:"GO:1905721"(mitotic spindle astral microtubule end)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR004953(EB1, C-terminal)|interpro:IPR027328|interpro:IPR027738|interpro:IPR036133|interpro:IPR036872|mint:Q9UPY8|rcsb pdb:1WYO|rcsb pdb:3CO1|rcsb pdb:3JAK|rcsb pdb:3JAL|rcsb pdb:3JAR|rcsb pdb:3TQ7|refseq:NM_012326.2(identity)|entrezgene/locuslink:22924(identity)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:LHuufxyNrygS3iFW5mmg13R43NE9606	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	intact-crc:3B6E12232F828DF2|rigid:XL9MNPPuKrxZcLoNx7evVqk8Aw0	false	protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7L591-3	uniprotkb:Q8TEW6	intact:EBI-10694655|ensembl:ENSP00000325174	intact:EBI-6918542|ensembl:ENSP00000344277|ensembl:ENSP00000455128|uniprotkb:O75209|uniprotkb:Q9BTP2|uniprotkb:Q9NVV3	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:dok4_human(display_long)|uniprotkb:DOK4(gene name)|psi-mi:DOK4(display_short)|uniprotkb:Downstream of tyrosine kinase 4(gene name synonym)|uniprotkb:Insulin receptor substrate 5(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701481|imex:IM-22632-722	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	ensembl:ENSG00000125170(gene)|ensembl:ENST00000340099(transcript)|ensembl:ENST00000569548(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0043410"(positive regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_060580.2|refseq:XP_005256100.1|entrezgene/locuslink:55715(identity)|refseq:NM_018110.3(identity)	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	rogid:Xc4aPsHtdQKj02Q5cqqgw29pSS09606	intact-crc:5019C99D02ED68AC|rigid:VUiYbDs/JrSzUQfDOdHbLd3vMyw	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:Q5VU92	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-10694873|uniprotkb:Q8IYK3|ensembl:ENSP00000360167	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:dc121_human(display_long)|uniprotkb:DCAF12L1(gene name)|psi-mi:DCAF12L1(display_short)|uniprotkb:WD repeat-containing protein 40B(gene name synonym)|uniprotkb:WDR40B(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701495|imex:IM-22632-723	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	refseq:NP_848565.2|ensembl:ENSG00000198889(gene)|ensembl:ENST00000371126(transcript)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|entrezgene/locuslink:139170(identity)|refseq:NM_178470.4(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:n9k7CP2cQy1nTJU2wnezEdfYARk9606	intact-crc:C43961F067D1B7C2|rigid:ghSVX+bUay7Dm61mUSviSIv68hg	false	protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5R372-2	uniprotkb:Q03112	intact:EBI-10692254|ensembl:ENSP00000350027	intact:EBI-1384862|uniprotkb:Q16122|uniprotkb:Q99917|uniprotkb:C9JAK0|uniprotkb:Q5HYI1|uniprotkb:Q6MZS6|uniprotkb:Q8NEI5|uniprotkb:A1L4F3|uniprotkb:A8KA00|uniprotkb:B7Z8W7|uniprotkb:B7ZLQ3|uniprotkb:B7ZLQ4|uniprotkb:D3DNP7|ensembl:ENSP00000417899|intact:EBI-8475192|intact:MINT-8417693|uniprotkb:E7EQ57|uniprotkb:Q13465|uniprotkb:Q13466|uniprotkb:Q6FH90	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:mecom_human(display_long)|uniprotkb:MECOM(gene name)|psi-mi:MECOM(display_short)|uniprotkb:EVI1(gene name synonym)|uniprotkb:Ecotropic virus integration site 1 protein homolog(gene name synonym)|uniprotkb:MDS1(gene name synonym)|uniprotkb:Myelodysplasia syndrome 1 protein(gene name synonym)|uniprotkb:Myelodysplasia syndrome-associated protein 1(gene name synonym)|uniprotkb:MDS1 and EVI1 complex locus protein(gene name synonym)|uniprotkb:PRDM3(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701509|imex:IM-22632-724	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	refseq:NP_001098547.3|refseq:NP_001098548.2|refseq:NP_001157471.1|refseq:NP_001157472.1|refseq:NP_001192123.1|refseq:NP_004982.2|refseq:NP_005232.2|ensembl:ENSG00000085276(gene)|ensembl:ENST00000494292(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0071425"(hematopoietic stem cell proliferation)|interpro:IPR001214(SET)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR044411|mint:Q03112|rcsb pdb:6BW3|reactome:R-HSA-3214841|reactome:R-HSA-8943724|interpro:IPR036236|refseq:XP_016861363.1|refseq:XP_016861364.1|refseq:XP_016861365.1|refseq:XP_005247278.1|refseq:XP_005247280.1|refseq:XP_005247272.1|dip:DIP-38639N|refseq:XP_005247276.1|refseq:XP_005247277.1|entrezgene/locuslink:2122(identity)|refseq:XM_006713537.1(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2018/04/06	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	rogid:MAlEIuVZS4+BNoy50jejv2O30WA9606	intact-crc:4CE614FB76130EB8|rigid:bqT3Gw/k0vuCcK2LncEvdXLqIo8	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q5BJH2-2	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-10694905|ensembl:ENSP00000254742	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:q5bjh2-2(display_long)|uniprotkb:TMEM128(gene name)|psi-mi:TMEM128(display_short)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701523|imex:IM-22632-725	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	intact:EBI-10243515(isoform-parent)|ensembl:ENSG00000132406(gene)|ensembl:ENST00000254742(transcript)|uniprotkb:Q5BJH2-2(isoform-parent)|refseq:NM_032927.3(identity)|entrezgene/locuslink:85013(identity)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Suppl. table S8 and S9, fig. 3C and 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:fsGbysnORUH/y9LqInPSyP55P4k9606	intact-crc:2753CDF6183448D7|rigid:klLT6M6ns3E3y4A943lKESsyWbg	false	protein a tag:n-n|mutation decreasing interaction:86-86	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15205	uniprotkb:Q13387	intact:EBI-6657186|ensembl:ENSP00000366249|ensembl:ENSP00000373039|ensembl:ENSP00000396152|ensembl:ENSP00000410416|uniprotkb:Q96EC7|uniprotkb:Q5STL2|uniprotkb:B0UZT6|uniprotkb:Q5SUK2	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:ubd_human(display_long)|uniprotkb:UBD(gene name)|psi-mi:UBD(display_short)|uniprotkb:Diubiquitin(gene name synonym)|uniprotkb:FAT10(gene name synonym)|uniprotkb:Ubiquitin-like protein FAT10(gene name synonym)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701539|imex:IM-22632-726	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000231968(gene)|ensembl:ENST00000377050(transcript)|ensembl:ENST00000383547(transcript)|ensembl:ENST00000421519(transcript)|ensembl:ENST00000432676(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016235"(aggresome)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|ensembl:ENSG00000206468(gene)|ensembl:ENSG00000213886(gene)|ensembl:ENSG00000228913(gene)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0070628"(proteasome binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|interpro:IPR042969|rcsb pdb:2MBE|rcsb pdb:6GF1|rcsb pdb:6GF2|reactome:R-HSA-8951664|refseq:NP_006389.2|entrezgene/locuslink:10537(identity)|refseq:NM_006398.3(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:ySUgohBHmcPaAaD/l21zkQ3+MPI9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:73DCB2159D926E59|rigid:rLhCDLAx9wPuip0MInXtSn5dBug	false	protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5R372-2	uniprotkb:Q13387	intact:EBI-10692254|ensembl:ENSP00000350027	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701553|imex:IM-22632-727	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:010E7A8C3068F47E|rigid:fqTDxEqPpai9DYa6srLDL8VbfDA	false	protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:P62993	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701567|imex:IM-22632-728	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:B676E13FC08FD35C|rigid:XPynkuGbb/0GBQXNGhOl1yLKT84	false	protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q16643	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-351394|uniprotkb:Q9UFZ5|uniprotkb:B2RBG0|ensembl:ENSP00000308532|intact:EBI-4404710|uniprotkb:A8MV58	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:dreb_human(display_long)|uniprotkb:DBN1(gene name)|psi-mi:DBN1(display_short)|uniprotkb:Developmentally-regulated brain protein(gene name synonym)|uniprotkb:D0S117E(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701581|imex:IM-22632-729	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	refseq:NP_004386.2|refseq:NP_543157.1|refseq:XP_005265884.1|ensembl:ENSG00000113758(gene)|ensembl:ENST00000309007(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0042641"(actomyosin)|go:"GO:0030425"(dendrite)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051015"(actin filament binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028438|interpro:IPR029006|mint:Q16643|go:"GO:0030426"(growth cone)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031915"(positive regulation of synaptic plasticity)|rcsb pdb:5Y1Z|rcsb pdb:5ZZ9|reactome:R-HSA-9013405|reactome:R-HSA-9013407|reactome:R-HSA-9013418|reactome:R-HSA-9013422|go:"GO:0032507"(maintenance of protein location in cell)|refseq:XP_016864629.1|refseq:NM_004395.3(identity)|entrezgene/locuslink:1627(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:0+VPJM5mTuG2jzmzGG3iLswmCUc9606	intact-crc:58E2086D02EDA102|rigid:bK7RLAO4Bt4GqOKnUzGxYpPX+AE	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:P55072	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701595|imex:IM-22632-730	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N|refseq:NM_007126.3(identity)|entrezgene/locuslink:7415(identity)	-	-	-	figure legend:Suppl. table S8 and S9, fig. 3C and 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606	intact-crc:7BA6BE8C2BA53E67|rigid:p/r1PEfHpVYXmq6Zo4T+A4jzgGQ	false	protein a tag:n-n|mutation decreasing interaction:86-86	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27986-2	uniprotkb:P35568	intact:EBI-9090282|ensembl:ENSP00000338554	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701611|imex:IM-22632-731	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772|refseq:NM_005544.2(identity)|entrezgene/locuslink:3667(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	intact-crc:67A0EE38D1FCDB7C|rigid:VQtrgiFLafp63gbkUkDVm2Cv+L8	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06400	uniprotkb:P62993	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701625|imex:IM-22632-732	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N|entrezgene/locuslink:5925(identity)|refseq:NM_000321.2(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	figure legend:Suppl. table S8, fig. 3C and 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:xidCNX96KlQzu160polvT61k4Zw9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:C8CA7C59739F32E8|rigid:KAHMJQFt20oWWb7C6Rd4QnhRCGQ	false	firefly luciferase protein tag:n-n	protein a tag:n-n|mutation decreasing interaction:86-86	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95073-2	uniprotkb:P16885	intact:EBI-10696047	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	psi-mi:o95073-2(display_long)|uniprotkb:FSBP(gene name)|psi-mi:FSBP(display_short)	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701641|imex:IM-22632-733	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1059030(isoform-parent)|uniprotkb:O95073-2(isoform-parent)|refseq:NM_001256141.1(identity)|entrezgene/locuslink:25788(identity)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:j4ktleFZa7rAjRFENAKAGdAd+Fs9606	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	intact-crc:C340BADDD25A2210|rigid:hfYkVkDo8SgBQrgLcI7v+iRf9kM	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95073-2	uniprotkb:Q9NP31	intact:EBI-10696047	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:o95073-2(display_long)|uniprotkb:FSBP(gene name)|psi-mi:FSBP(display_short)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701655|imex:IM-22632-734	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1059030(isoform-parent)|uniprotkb:O95073-2(isoform-parent)|refseq:NM_001256141.1(identity)|entrezgene/locuslink:25788(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:j4ktleFZa7rAjRFENAKAGdAd+Fs9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:D17508475441CFBC|rigid:Lde1jqg/PztZOpetnIF4yx2YKwU	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75815	uniprotkb:P35568	intact:EBI-702336|uniprotkb:Q6UW40|uniprotkb:Q9BR50|uniprotkb:D3DT43|uniprotkb:Q5TEW3|ensembl:ENSP00000260502|ensembl:ENSP00000359263|ensembl:ENSP00000359264	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	psi-mi:bcar3_human(display_long)|uniprotkb:SH2 domain-containing protein 3B(gene name synonym)|uniprotkb:Novel SH2-containing protein 2(gene name synonym)|uniprotkb:BCAR3(gene name)|psi-mi:BCAR3(display_short)|uniprotkb:NSP2(gene name synonym)|uniprotkb:SH2D3B(gene name synonym)|uniprotkb:UNQ271/PRO308(orf name)	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701669|imex:IM-22632-735	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003558.1|refseq:NP_001248339.1|refseq:NP_001295180.1|refseq:NP_001248337.1|refseq:NP_001248338.1|refseq:XP_016857969.1|dip:DIP-33857N|ensembl:ENSG00000137936(gene)|ensembl:ENST00000260502(transcript)|ensembl:ENST00000370243(transcript)|ensembl:ENST00000370244(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042493"|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0086100"(endothelin receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR023578|interpro:IPR028849|interpro:IPR036860|interpro:IPR036964|interpro:IPR044102|mint:O75815|rcsb pdb:3T6A|refseq:NM_003567.3(identity)|entrezgene/locuslink:8412(identity)	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772|refseq:NM_005544.2(identity)|entrezgene/locuslink:3667(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:r4mh2ZDGa0AleYRBV+oAiDds1+w9606	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	intact-crc:8307C55E9801E691|rigid:hXY4VdfEmUyftOI+vwotwWGjjWM	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60636	uniprotkb:P62993	intact:EBI-3914288|uniprotkb:Q8WU05|uniprotkb:Q5TET2|ensembl:ENSP00000358529|uniprotkb:D6PTH4	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:tsn2_human(display_long)|uniprotkb:TSPAN2(gene name)|psi-mi:TSPAN2(display_short)|uniprotkb:Tetraspan NET-3(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701683|imex:IM-22632-736	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001295245.1|refseq:NP_005716.2|ensembl:ENSG00000134198(gene)|ensembl:ENST00000369516(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014005"(microglia development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042552"(myelination)|go:"GO:0043209"(myelin sheath)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061564"(axon development)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|refseq:NM_005725.4(identity)|entrezgene/locuslink:10100(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	figure legend:Suppl. table S8 and S9, fig. 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:aAvB/0QxH0/5YF5dkbBh5wpz3uw9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:0E507D6904FFEC54|rigid:G4awIUPqy2QhVyRj9zHTAk2jFhw	false	firefly luciferase protein tag:n-n	protein a tag:n-n|mutation decreasing interaction:86-86	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43559	uniprotkb:O43559	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701699|imex:IM-22632-737	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	intact-crc:3166F63C324206F3|rigid:SQs92b+3MkA9e4CdK9s8GCo5cDw	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08631-2	uniprotkb:O43559	intact:EBI-9834454|ensembl:ENSP00000429848|ensembl:ENSP00000486627	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	psi-mi:p08631-2(display_long)|uniprotkb:p59-HCK(isoform synonym)|uniprotkb:p59Hck(isoform synonym)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701713|imex:IM-22632-738	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:P08631-2(isoform-parent)|intact:EBI-346340(isoform-parent)|ensembl:ENSG00000101336(gene)|ensembl:ENST00000520553(transcript)|ensembl:ENST00000629881(transcript)|entrezgene/locuslink:3055(identity)|refseq:NM_001172129.1(identity)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	-	isoform-comment:Initiator Met-1 is removed. Contains a N-myristoyl glycine at position 2. Contains a S-palmitoyl cysteine at position 3.	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:qSgfntp+jqdyi7qsc7u7UA7ylO09606	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	intact-crc:6A23E4F191C37F10|rigid:9FHlOXWJB6TGs5laj+Z5+QcJqWk	false	protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43559	uniprotkb:Q92569	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701727|imex:IM-22632-739	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:C56FD1E30F4014CF|rigid:fscct1zSG/oVWU61u/B9+IW1+EA	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43242	uniprotkb:P16885	intact:EBI-357622|uniprotkb:Q96EI2|uniprotkb:Q9BQA4|ensembl:ENSP00000264639|uniprotkb:B4DT72|uniprotkb:B3KMW9	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	psi-mi:psmd3_human(display_long)|uniprotkb:PSMD3(gene name)|psi-mi:PSMD3(display_short)|uniprotkb:Proteasome subunit p58(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S3(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN3(gene name synonym)	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701741|imex:IM-22632-740	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000108344(gene)|ensembl:ENST00000264639(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|mint:O43242|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|reactome:R-HSA-174113|reactome:R-HSA-174154|rcsb pdb:5VHH|rcsb pdb:5VHI|reactome:R-HSA-174178|rcsb pdb:5VHS|reactome:R-HSA-174184|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-180534|rcsb pdb:6MSJ|reactome:R-HSA-180585|reactome:R-HSA-187577|rcsb pdb:6MSK|reactome:R-HSA-195253|reactome:R-HSA-202424|rcsb pdb:6WJD|reactome:R-HSA-211733|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-174084|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5607761|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8854050|refseq:NP_002800.2|dip:DIP-27571N|entrezgene/locuslink:5709(identity)|refseq:NM_002809.3(identity)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	-	-	-	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:C6CStW89nIAA3mzubyv5wfBwPHk9606	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	intact-crc:433B6B3F02EBA313|rigid:hHLh1EqtOW13WQftdtrcPaDZNm4	false	firefly luciferase protein tag:n-n	protein a tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14713	intact:EBI-10696484	intact:EBI-2127319|uniprotkb:O14714|uniprotkb:D6W4Y9|uniprotkb:Q53RS0|ensembl:ENSP00000347504|ensembl:ENSP00000353850	-	psi-mi:itbp1_human(display_long)|uniprotkb:ITGB1BP1(gene name)|psi-mi:ITGB1BP1(display_short)|uniprotkb:ICAP1(gene name synonym)|uniprotkb:Integrin cytoplasmic domain-associated protein 1(gene name synonym)	psi-mi:pgrmc1(display_short)|psi-mi:EBI-10696484(display_long)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701755|imex:IM-22632-741	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011508718.1|refseq:NP_004754.1|refseq:NP_071729.1|refseq:XP_016860758.1|refseq:XP_016860759.1|refseq:XP_016860756.1|refseq:XP_016860757.1|refseq:NP_001305995.1|refseq:NP_001305996.1|refseq:NP_001305997.1|refseq:XP_006711966.1|refseq:XP_005246240.1|refseq:XP_005246241.1|refseq:XP_005246242.1|refseq:XP_005246246.1|ensembl:ENSG00000119185(gene)|ensembl:ENST00000355346(transcript)|ensembl:ENST00000360635(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006933"(negative regulation of cell adhesion involved in substrate-bound cell migration)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033622"(integrin activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035148"(tube formation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051451"(myoblast migration)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090315"(negative regulation of protein targeting to membrane)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR019517|rcsb pdb:1K11|rcsb pdb:4DX8|rcsb pdb:4DX9|rcsb pdb:4JIF|refseq:NM_004763.3(identity)|entrezgene/locuslink:9270(identity)	entrezgene/locuslink:10857(identity)|refseq:NM_006667.4(identity)	-	-	no-uniprot-update:	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:QxRmizA77Dvcwg8rkqt1bt3sI2U9606	rogid:rMnUy1tXawu+c/+lVvFyzcL9yYc9606	intact-crc:93791D8E6FF6E940|rigid:GHmL0u6RXyBdLJ/aq9OjDSCjOCM	false	protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	intact:EBI-10696575	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	-	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:znf767(display_short)|psi-mi:EBI-10696575(display_long)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701769|imex:IM-22632-742	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	entrezgene/locuslink:79970(identity)|refseq:XM_005249956.1(identity)	-	-	no-uniprot-update:	figure legend:Suppl. table S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:bmyvECfdUfkpegeqBiK1W412c5s9606	intact-crc:1C78A167C7569B68|rigid:zBLBhiA3EbMsU1GvRVot+/BSx3o	false	protein a tag:n-n	firefly luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y5E4	uniprotkb:P62993	intact:EBI-1045222|uniprotkb:Q9UFU9|uniprotkb:Q549F4|ensembl:ENSP00000231134	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:pcdb5_human(display_long)|uniprotkb:PCDHB5(gene name)|psi-mi:PCDHB5(display_short)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701786|imex:IM-22632-743	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113209(gene)|ensembl:ENST00000231134(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0045202"(synapse)|interpro:IPR002126(Cadherin)|interpro:IPR013164(Cadherin, N-terminal)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR030730|interpro:IPR032455|refseq:NP_056484.2|refseq:NM_015669.3(identity)|entrezgene/locuslink:26167(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), SYK (P43405), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:JHnksp8PK/4ubg/jnTZBT/uiLlk9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:E1A6ADA6292ECFBB|rigid:wBDgV3oNiGoB1Z8n+18JNIenEks	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y3I0	uniprotkb:Q9UKG1	intact:EBI-2107208|uniprotkb:Q6IAI0|uniprotkb:Q9BWL4|uniprotkb:Q9NTH1|uniprotkb:Q9P037|uniprotkb:Q9P0J3|uniprotkb:B2R6A8|intact:EBI-4399544|ensembl:ENSP00000216038	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:rtcb_human(display_long)|uniprotkb:3'-phosphate/5'-hydroxy nucleic acid ligase(gene name synonym)|uniprotkb:C22orf28(gene name synonym)|uniprotkb:HSPC117(orf name)|uniprotkb:RTCB(gene name)|psi-mi:RTCB(display_short)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701797|imex:IM-22632-744	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055121.1|dip:DIP-46750N|ensembl:ENSG00000100220(gene)|ensembl:ENST00000216038(transcript)|go:"GO:0000971"(tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate)|go:"GO:0003723"(RNA binding)|go:"GO:0003972"("RNA ligase (ATP) activity")|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0017166"(vinculin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0072669"(tRNA-splicing ligase complex)|interpro:IPR001233(Protein of unknown function UPF0027)|interpro:IPR027513|interpro:IPR036025|mint:Q9Y3I0|reactome:R-HSA-6784531|entrezgene/locuslink:51493(identity)|refseq:NM_014306.4(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:URuCEq/DIn6DgR3jOb5fwnpDVXE9606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:C1050C0CB058E0D0|rigid:cX6dThTWLBA6ZO4DmhaT9CvB0Dc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2X9	uniprotkb:P40763	intact:EBI-396200|uniprotkb:Q9NY92|uniprotkb:A6NF48|uniprotkb:B3KMX2|uniprotkb:Q5RKW5|intact:EBI-11018373|ensembl:ENSP00000294740|ensembl:ENSP00000356322	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:zn281_human(display_long)|uniprotkb:ZNF281(gene name)|psi-mi:ZNF281(display_short)|uniprotkb:GZP1(gene name synonym)|uniprotkb:ZBP99(gene name synonym)|uniprotkb:Zinc finger DNA-binding protein 99(gene name synonym)|uniprotkb:Transcription factor ZBP-99(gene name synonym)|uniprotkb:GC-box-binding zinc finger protein 1(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701808|imex:IM-22632-745	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036614.1|refseq:NP_001268222.1|refseq:NP_001268223.1|refseq:XP_016856376.1|refseq:XP_016856377.1|ensembl:ENSG00000162702(gene)|ensembl:ENST00000294740(transcript)|ensembl:ENST00000367353(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9Y2X9|entrezgene/locuslink:23528(identity)|refseq:NM_012482.4(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:bjmz9ne6FkC0kbJUv13u8IoDYHM9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:A07AF40AEE6E1FD3|rigid:E+9OytdhQ8VjK+tM1xm/HwBLzEo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2X9	uniprotkb:Q92569	intact:EBI-396200|uniprotkb:Q9NY92|uniprotkb:A6NF48|uniprotkb:B3KMX2|uniprotkb:Q5RKW5|intact:EBI-11018373|ensembl:ENSP00000294740|ensembl:ENSP00000356322	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:zn281_human(display_long)|uniprotkb:ZNF281(gene name)|psi-mi:ZNF281(display_short)|uniprotkb:GZP1(gene name synonym)|uniprotkb:ZBP99(gene name synonym)|uniprotkb:Zinc finger DNA-binding protein 99(gene name synonym)|uniprotkb:Transcription factor ZBP-99(gene name synonym)|uniprotkb:GC-box-binding zinc finger protein 1(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701819|imex:IM-22632-746	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036614.1|refseq:NP_001268222.1|refseq:NP_001268223.1|refseq:XP_016856376.1|refseq:XP_016856377.1|ensembl:ENSG00000162702(gene)|ensembl:ENST00000294740(transcript)|ensembl:ENST00000367353(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9Y2X9|entrezgene/locuslink:23528(identity)|refseq:NM_012482.4(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:bjmz9ne6FkC0kbJUv13u8IoDYHM9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:B7482B34D2606215|rigid:ITUn8Irqdixigyt+DueEZcAK0Yw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UPY8	uniprotkb:Q8NEU8	intact:EBI-726739|uniprotkb:O00265|uniprotkb:Q6FI15|uniprotkb:Q9BZP7|uniprotkb:Q9BZP8|uniprotkb:B7WPK5|uniprotkb:Q6FHB0|ensembl:ENSP00000233121	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	psi-mi:mare3_human(display_long)|uniprotkb:End-binding protein 3(gene name synonym)|uniprotkb:EB1 protein family member 3(gene name synonym)|uniprotkb:RP3(gene name synonym)|uniprotkb:MAPRE3(gene name)|psi-mi:MAPRE3(display_short)	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701830|imex:IM-22632-747	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036458.2|refseq:XP_016859086.1|refseq:NP_001289979.1|refseq:XP_006712030.1|refseq:XP_011531002.1|dip:DIP-56069N|ensembl:ENSG00000084764(gene)|ensembl:ENST00000233121(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042802"(identical protein binding)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:1903033"(positive regulation of microtubule plus-end binding)|go:"GO:1904825"(protein localization to microtubule plus-end)|go:"GO:1905721"(mitotic spindle astral microtubule end)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR004953(EB1, C-terminal)|interpro:IPR027328|interpro:IPR027738|interpro:IPR036133|interpro:IPR036872|mint:Q9UPY8|rcsb pdb:1WYO|rcsb pdb:3CO1|rcsb pdb:3JAK|rcsb pdb:3JAL|rcsb pdb:3JAR|rcsb pdb:3TQ7|refseq:NM_012326.2(identity)|entrezgene/locuslink:22924(identity)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FRK (P42685), JAK2 (O60674), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:LHuufxyNrygS3iFW5mmg13R43NE9606	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	intact-crc:C0AFE913338AC068|rigid:XL9MNPPuKrxZcLoNx7evVqk8Aw0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKA8	uniprotkb:Q13322	intact:EBI-9091952|uniprotkb:A4GU14|uniprotkb:Q9UKA7|uniprotkb:E7ENV1|uniprotkb:Q5ECL3|uniprotkb:A4LA69|uniprotkb:Q5TGC6|uniprotkb:E7EWD8|uniprotkb:Q9NUC8|uniprotkb:E3VWE2|uniprotkb:E5L4P0|uniprotkb:E5L4P7|uniprotkb:G1FI66|uniprotkb:G1FLF0|ensembl:ENSP00000363516|ensembl:ENSP00000445401	intact:EBI-80275|uniprotkb:O00427|uniprotkb:O00701|uniprotkb:O75222|uniprotkb:Q92606|uniprotkb:Q92907|uniprotkb:Q92948|intact:EBI-1760363|ensembl:ENSP00000381793|ensembl:ENSP00000385770|intact:EBI-1965437|uniprotkb:A7VJ95|uniprotkb:A4D258|uniprotkb:A8K0E6|uniprotkb:D3DVM9	psi-mi:rcan3_human(display_long)|uniprotkb:DSCR1L2(gene name synonym)|uniprotkb:Down syndrome candidate region 1-like protein 2(gene name synonym)|uniprotkb:Myocyte-enriched calcineurin-interacting protein 3(gene name synonym)|uniprotkb:Regulator of calcineurin 3(gene name synonym)|uniprotkb:RCAN3(gene name)|psi-mi:RCAN3(display_short)	psi-mi:grb10_human(display_long)|uniprotkb:GRB10(gene name)|psi-mi:GRB10(display_short)|uniprotkb:GRBIR(gene name synonym)|uniprotkb:KIAA0207(gene name synonym)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Insulin receptor-binding protein Grb-IR(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701841|imex:IM-22632-748	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001238911.1|refseq:NP_001238912.1|refseq:NP_001238914.1|refseq:NP_038469.1|refseq:NP_001238906.1|refseq:NP_001238907.1|refseq:NP_001238908.1|refseq:NP_001238909.1|refseq:NP_001238910.1|refseq:NP_001238913.1|ensembl:ENSG00000117602(gene)|ensembl:ENST00000374395(transcript)|ensembl:ENST00000538532(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031013"(troponin I binding)|interpro:IPR006931(Calcipressin)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034923|interpro:IPR035979|refseq:NM_001251979.1(identity)|entrezgene/locuslink:11123(identity)	go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904738"(vascular associated smooth muscle cell migration)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035036|interpro:IPR035037|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q13322|rcsb pdb:1NRV|rcsb pdb:3HK0|reactome:R-HSA-1433557|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-9607240|reactome:R-HSA-9648895|ensembl:ENSG00000106070(gene)|ensembl:ENST00000398812(transcript)|ensembl:ENST00000401949(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010467"(gene expression)|refseq:XP_011513606.1|refseq:XP_011513614.1|refseq:XP_011513618.1|refseq:NP_001001549.1|refseq:NP_001001550.1|refseq:NP_001001555.1|refseq:NP_005302.3|refseq:XP_016867534.1|refseq:XP_016867535.1|refseq:XP_016867552.1|refseq:XP_016867553.1|refseq:XP_016867554.1|refseq:XP_016867555.1|refseq:XP_016867556.1|refseq:XP_016867557.1|dip:DIP-31657N|refseq:NM_001001550.2(identity)|entrezgene/locuslink:2887(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:GcjmPxKst3ISAOr1WMhJLrYq8JY9606	rogid:WBLkjS4iCC2gMTzR3izSFXGrBnk9606	intact-crc:4B4CF7FB5EEE1A02|rigid:RZk1QOuo+ApD3Yvs9QnA7TkBcmQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P104-2	uniprotkb:Q9UIL1-3	intact:EBI-10692909|ensembl:ENSP00000379270	intact:EBI-10692913	psi-mi:q9p104-2(display_long)|uniprotkb:DOK5(gene name)|psi-mi:DOK5(display_short)|uniprotkb:C20orf180(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 5(gene name synonym)|uniprotkb:Insulin receptor substrate 6(gene name synonym)	psi-mi:q9uil1-3(display_long)|uniprotkb:SCOC(gene name)|psi-mi:SCOC(display_short)|uniprotkb:SCOCO(gene name synonym)|uniprotkb:HRIHFB2072(orf name)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701852|imex:IM-22632-749	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101134(gene)|ensembl:ENST00000395939(transcript)|intact:EBI-739600(isoform-parent)|uniprotkb:Q9P104-2(isoform-parent)|refseq:NM_177959.2(identity)|entrezgene/locuslink:55816(identity)	intact:EBI-2686537(isoform-parent)|uniprotkb:Q9UIL1-3(isoform-parent)|entrezgene/locuslink:60592(identity)|refseq:NM_001153635.1(identity)	-	isoform-comment:No experimental confirmation available.	isoform-comment:No experimental confirmation available.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FES (P07332), PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8p18JpE/uszPiQyb4FtcEu5QiOc9606	rogid:jS3ZpyUvY0MRgdySRnveYgX0raU9606	intact-crc:E40FA939517626A1|rigid:2FhzqFejY+mluU82Feq1fTRH5rs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q9UHJ3	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-747398|uniprotkb:Q96C73|uniprotkb:Q9Y4Q9|uniprotkb:Q402F7|ensembl:ENSP00000378235	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:smbt1_human(display_long)|uniprotkb:Renal ubiquitous protein 1(gene name synonym)|uniprotkb:SFMBT1(gene name)|psi-mi:SFMBT1(display_short)|uniprotkb:RU1(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701874|imex:IM-22632-751	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	refseq:XP_006713266.1|refseq:XP_006713267.1|refseq:NP_057413.2|refseq:XP_011532126.1|refseq:XP_011532127.1|refseq:XP_005265278.1|ensembl:ENSG00000163935(gene)|ensembl:ENST00000394752(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048635"(negative regulation of muscle organ development)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR004092(Mbt repeat)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR021987|interpro:IPR037604|interpro:IPR038348|mint:Q9UHJ3|refseq:NM_016329.3(identity)|entrezgene/locuslink:51460(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:vh/dDMpcLQEo57Wcjnggufh6HRk9606	intact-crc:8A5796AE73B39824|rigid:Co74Mnmuxcvm2i1yp5rZc7voUiw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:Q9UIH9	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-2796400|ensembl:ENSP00000296233	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:klf15_human(display_long)|uniprotkb:KKLF(gene name synonym)|uniprotkb:Kidney-enriched krueppel-like factor(gene name synonym)|uniprotkb:KLF15(gene name)|psi-mi:KLF15(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701863|imex:IM-22632-750	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	refseq:NP_054798.1|refseq:XP_005247457.1|ensembl:ENSG00000163884(gene)|ensembl:ENST00000296233(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016607"(nuclear speck)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9UIH9|rcsb pdb:2ENT|reactome:R-HSA-1368108|entrezgene/locuslink:28999(identity)|refseq:NM_014079.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:vocV1ptKE68rlXylNPMj/4qjo689606	intact-crc:6843A2677B861246|rigid:PKw27QqRSHQEGeBOXXTxdFdOz0I	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14449	uniprotkb:Q9P289-3	intact:EBI-2680889|uniprotkb:B7Z7F9|uniprotkb:Q7Z6I1|ensembl:ENSP00000263915	intact:EBI-10693004|ensembl:ENSP00000419702	psi-mi:grb14_human(display_long)|uniprotkb:GRB14 adapter protein(gene name synonym)|uniprotkb:GRB14(gene name)|psi-mi:GRB14(display_short)	psi-mi:q9p289-3(display_long)|uniprotkb:STK26(gene name)|psi-mi:STK26(display_short)|uniprotkb:MASK(gene name synonym)|uniprotkb:MST3 and SOK1-related kinase(gene name synonym)|uniprotkb:MST4(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase MASK(gene name synonym)|uniprotkb:MST4a(isoform synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701885|imex:IM-22632-752	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004481.2|refseq:NP_001290351.1|ensembl:ENSG00000115290(gene)|ensembl:ENST00000263915(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035034|interpro:IPR035035|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q14449|rcsb pdb:2AUG|rcsb pdb:2AUH|rcsb pdb:4K81|reactome:R-HSA-210993|go:"GO:0008286"(insulin receptor signaling pathway)|dip:DIP-42605N|entrezgene/locuslink:2888(identity)|refseq:NM_004490.2(identity)	ensembl:ENSG00000134602(gene)|ensembl:ENST00000496850(transcript)|intact:EBI-618239(isoform-parent)|entrezgene/locuslink:51765(identity)|refseq:NM_001042452.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:b3Xtmki3fCyyoRra/IQWuGIQDCU9606	rogid:YBiuuqETpdEu0sZrYy4YI8bJsU49606	intact-crc:0516E31D279725B5|rigid:UUdMUCf5qTJKOSCWQCAKR9z/RC4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7L591-3	uniprotkb:Q9P104-2	intact:EBI-10694655|ensembl:ENSP00000325174	intact:EBI-10692909|ensembl:ENSP00000379270	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:q9p104-2(display_long)|uniprotkb:DOK5(gene name)|psi-mi:DOK5(display_short)|uniprotkb:C20orf180(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 5(gene name synonym)|uniprotkb:Insulin receptor substrate 6(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701896|imex:IM-22632-753	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	ensembl:ENSG00000101134(gene)|ensembl:ENST00000395939(transcript)|intact:EBI-739600(isoform-parent)|uniprotkb:Q9P104-2(isoform-parent)|refseq:NM_177959.2(identity)|entrezgene/locuslink:55816(identity)	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	isoform-comment:No experimental confirmation available.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	rogid:8p18JpE/uszPiQyb4FtcEu5QiOc9606	intact-crc:2FF681E5CD2F6FB7|rigid:aihE6IkdGbQDmizsxslwErGnhGI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NR55	uniprotkb:Q9UKG1	intact:EBI-10312707|ensembl:ENSP00000243440	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:batf3_human(display_long)|uniprotkb:BATF3(gene name)|psi-mi:BATF3(display_short)|uniprotkb:21 kDa small nuclear factor isolated from T-cells(gene name synonym)|uniprotkb:Jun dimerization protein p21SNFT(gene name synonym)|uniprotkb:SNFT(gene name synonym)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701929|imex:IM-22632-756	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061134.1|ensembl:ENSG00000123685(gene)|ensembl:ENST00000243440(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029818|entrezgene/locuslink:55509(identity)|refseq:NM_018664.2(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:hAyP6YHxONSUFMehlesRDi+E0z49606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:ABE60E681352E459|rigid:++3gYcSFd+4WtPDXwhGVp/QbHmo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y600	uniprotkb:Q9NRF2-2	intact:EBI-7095219|ensembl:ENSP00000410648|ensembl:ENSP00000415485|intact:MINT-4832217|uniprotkb:Q9UNJ5|uniprotkb:Q9Y601|uniprotkb:Q4QQH9|uniprotkb:A8K0U4	intact:EBI-10691662|ensembl:ENSP00000337163|ensembl:ENSP00000378903	psi-mi:csad_human(display_long)|uniprotkb:CSAD(gene name)|psi-mi:CSAD(display_short)|uniprotkb:CSD(gene name synonym)|uniprotkb:Cysteine-sulfinate decarboxylase(gene name synonym)|uniprotkb:Sulfinoalanine decarboxylase(gene name synonym)|uniprotkb:Aspartate 1-decarboxylase(gene name synonym)	psi-mi:q9nrf2-2(display_long)|uniprotkb:SH2B1(gene name)|psi-mi:SH2B1(display_short)|uniprotkb:KIAA1299(gene name synonym)|uniprotkb:Pro-rich, PH and SH2 domain-containing signaling mediator(gene name synonym)|uniprotkb:SH2 domain-containing protein 1B(gene name synonym)|uniprotkb:SH2B(gene name synonym)|uniprotkb:Beta(isoform synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701918|imex:IM-22632-755	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011536748.1|ensembl:ENSG00000139631(gene)|ensembl:ENST00000444623(transcript)|ensembl:ENST00000453446(transcript)|go:"GO:0004068"(aspartate 1-decarboxylase activity)|go:"GO:0004782"(sulfinoalanine decarboxylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0019449"(L-cysteine catabolic process to hypotaurine)|go:"GO:0019452"(L-cysteine catabolic process to taurine)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042412"(taurine biosynthetic process)|interpro:IPR002129(Pyridoxal phosphate-dependent decarboxylase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:2JIS|reactome:R-HSA-1614558|refseq:NP_057073.4|refseq:NP_001231634.1|entrezgene/locuslink:51380(identity)|refseq:NM_001244706.1(identity)	ensembl:ENSG00000178188(gene)|ensembl:ENST00000337120(transcript)|ensembl:ENST00000395532(transcript)|intact:EBI-310491(isoform-parent)|uniprotkb:Q9NRF2-2(isoform-parent)|refseq:NM_001145796.1(identity)|entrezgene/locuslink:25970(identity)	-	comment:mint|comment:homomint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FRK (P42685), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:RSNULVRWt2RLIewda7I1hk8HAeY9606	rogid:5DkSyDavhqIn9glTuxAXN/pKPC09606	intact-crc:499897A824686891|rigid:FSgjqozx/M86YucO9BG7eRZU3iI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:Q9NSI6-4	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-10693038|ensembl:ENSP00000342106	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:q9nsi6-4(display_long)|uniprotkb:BRWD1(gene name)|psi-mi:BRWD1(display_short)|uniprotkb:C21orf107(gene name synonym)|uniprotkb:WD repeat-containing protein 9(gene name synonym)|uniprotkb:WDR9(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701907|imex:IM-22632-754	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	intact:EBI-1996384(isoform-parent)|uniprotkb:Q9NSI6-4(isoform-parent)|ensembl:ENSG00000185658(gene)|ensembl:ENST00000341322(transcript)|entrezgene/locuslink:54014(identity)|refseq:NM_001007246.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:vfir0aZ5Af/ptv8i+BAAGpNn5wg9606	intact-crc:1A3FB64C077E09ED|rigid:WHNUg8Hp8MdskMRt6mH9RIRqiP4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NPB6-2	uniprotkb:P62993	intact:EBI-10693102|ensembl:ENSP00000392388	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:q9npb6-2(display_long)|uniprotkb:PARD6A(gene name)|psi-mi:PARD6A(display_short)|uniprotkb:PAR6A(gene name synonym)|uniprotkb:PAR6C(gene name synonym)|uniprotkb:Tax interaction protein 40(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701951|imex:IM-22632-758	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-81876(isoform-parent)|ensembl:ENSG00000102981(gene)|ensembl:ENST00000458121(transcript)|uniprotkb:Q9NPB6-2(isoform-parent)|refseq:NM_001037281.1(identity)|entrezgene/locuslink:50855(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), SYK (P43405), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:hLX1kt+/BGPnr4HvpWndVysxrTU9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:1F28A724FB150D33|rigid:LuRVnZJWGHvsq8dtCFq7HwULj8g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q9NPC6	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-746712|uniprotkb:O43415|uniprotkb:Q9HB92|ensembl:ENSP00000306997	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:myoz2_human(display_long)|uniprotkb:Calsarcin-1(gene name synonym)|uniprotkb:FATZ-related protein 2(gene name synonym)|uniprotkb:MYOZ2(gene name)|psi-mi:MYOZ2(display_short)|uniprotkb:C4orf5(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701940|imex:IM-22632-757	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_057683.1|ensembl:ENSG00000172399(gene)|ensembl:ENST00000307128(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003779"(actin binding)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031433"(telethonin binding)|go:"GO:0043503"(skeletal muscle fiber adaptation)|go:"GO:0045214"(sarcomere organization)|go:"GO:0051373"(FATZ binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR008438(Calcineurin-binding)|refseq:NM_016599.4(identity)|entrezgene/locuslink:51778(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:Y2B5tDM2oGscI8xiTwB69hFEhL89606	intact-crc:2500F01378B299B5|rigid:2s+hGheVFSXSVatqE5DYzqfNZcM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP98	uniprotkb:P62993	intact:EBI-744402|ensembl:ENSP00000352272|uniprotkb:Q9H1I7	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:myoz1_human(display_long)|uniprotkb:Calsarcin-2(gene name synonym)|uniprotkb:Filamin-, actinin- and telethonin-binding protein(gene name synonym)|uniprotkb:Protein FATZ(gene name synonym)|uniprotkb:MYOZ1(gene name)|psi-mi:MYOZ1(display_short)|uniprotkb:MYOZ(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701962|imex:IM-22632-759	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177791(gene)|ensembl:ENST00000359322(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003779"(actin binding)|go:"GO:0004865"(protein serine/threonine phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030239"(myofibril assembly)|go:"GO:0031143"(pseudopodium)|go:"GO:0031433"(telethonin binding)|go:"GO:0042060"(wound healing)|go:"GO:0043417"(negative regulation of skeletal muscle tissue regeneration)|go:"GO:0043503"(skeletal muscle fiber adaptation)|go:"GO:0045214"(sarcomere organization)|go:"GO:0051373"(FATZ binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR008438(Calcineurin-binding)|mint:Q9NP98|rcsb pdb:7A8T|rcsb pdb:7A8U|refseq:NP_067068.1|rcsb pdb:7ANK|refseq:NM_021245.3(identity)|entrezgene/locuslink:58529(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:FRXTAudzeuW6TsUXL485GDV9ZX09606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:C63FD05A1796425E|rigid:lnHmHNm9QDND5vjWwXmVUyA349s	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:Q32MZ4-4	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-10240044|ensembl:ENSP00000310109	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:q32mz4-4(display_long)|uniprotkb:GC-binding factor 2(gene name synonym)|uniprotkb:GCF2(gene name synonym)|uniprotkb:TAR RNA-interacting protein(gene name synonym)|uniprotkb:TRIP(gene name synonym)|uniprotkb:LRRFIP1(gene name)|psi-mi:LRRFIP1(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701973|imex:IM-22632-760	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	intact:EBI-1369100(isoform-parent)|ensembl:ENSG00000124831(gene)|ensembl:ENST00000308482(transcript)|entrezgene/locuslink:9208(identity)|refseq:NM_001137551.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), CSK (P41240), FER (P16591), FGR (P09769), FYN (P06241), JAK3 (P52333)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:BBw6Zm3Kb8c4Jq9DUR6+QwjJXzM9606	intact-crc:5442A3E04496125C|rigid:1KWtYNU/MAvV8XmKuuYX11SmNA0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:Q96A09	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-752030|ensembl:ENSP00000289166	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:tet5b_human(display_long)|uniprotkb:TENT5B(gene name)|psi-mi:TENT5B(display_short)|uniprotkb:FAM46B(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701984|imex:IM-22632-761	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	refseq:NP_443175.2|ensembl:ENSG00000158246(gene)|ensembl:ENST00000289166(transcript)|go:"GO:0048255"(mRNA stabilization)|go:"GO:1990817"(RNA adenylyltransferase activity)|interpro:IPR012937(Protein of unknown function DUF1693)|entrezgene/locuslink:115572(identity)|refseq:NM_052943.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:hcI1m66Kt1B5RS3kqXhFmu0lNrg9606	intact-crc:7DDA3F065B5EAF78|rigid:y9rQGdkicQ8hFsiLKnWIr3y2iZ8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UF11-4	uniprotkb:Q9NP31	intact:EBI-9089825|ensembl:ENSP00000227214|ensembl:ENSP00000442616	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:q9uf11-4(display_long)|uniprotkb:EVT1(gene name synonym)|uniprotkb:Evectin-1(gene name synonym)|uniprotkb:KPL1(gene name synonym)|uniprotkb:PH domain-containing protein in retina 1(gene name synonym)|uniprotkb:PHR1(gene name synonym)|uniprotkb:PHRET1(gene name synonym)|uniprotkb:Pleckstrin homology domain retinal protein 1(gene name synonym)|uniprotkb:PLEKHB1(gene name)|psi-mi:PLEKHB1(display_short)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10701995|imex:IM-22632-762	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6447271(isoform-parent)|ensembl:ENSG00000021300(gene)|ensembl:ENST00000227214(transcript)|ensembl:ENST00000535129(transcript)|entrezgene/locuslink:58473(identity)|refseq:NM_001130035.1(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FRK (P42685), FYN (P06241), JAK2 (O60674), SYK (P43405)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:5RmF2rJLHJT3yM6ZP4+m7unTGNs9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:93E2A035A590433F|rigid:OG0e/at7nc4V8Xy07NpI6744KlI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q9NP31	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702006|imex:IM-22632-763	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:A678792FDE5E4B0E|rigid:M44s/PAj0o5eyb+1TqIeSXUm1YU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q9NP31	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702017|imex:IM-22632-764	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:9A8FD8461EE50110|rigid:cZ4wLCmnoAbpq3Gj29dHtEGHQnQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q9NP31	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702039|imex:IM-22632-766	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:97D44D2DA83A2064|rigid:9IhtipCdg1OD6tsl6/DeyNKPvC0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27986-2	uniprotkb:Q9NP31	intact:EBI-9090282|ensembl:ENSP00000338554	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702028|imex:IM-22632-765	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:7FA7136E36091901|rigid:08gAcWchF1amVgDcetEj9So911A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95073-2	uniprotkb:Q9NP31	intact:EBI-10696047	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:o95073-2(display_long)|uniprotkb:FSBP(gene name)|psi-mi:FSBP(display_short)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702050|imex:IM-22632-767	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1059030(isoform-parent)|uniprotkb:O95073-2(isoform-parent)|refseq:NM_001256141.1(identity)|entrezgene/locuslink:25788(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	isoform-comment:No experimental confirmation available.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:j4ktleFZa7rAjRFENAKAGdAd+Fs9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:4E260D67626EBD28|rigid:Lde1jqg/PztZOpetnIF4yx2YKwU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TBB1	uniprotkb:Q9NP31	intact:EBI-739832|uniprotkb:Q4W5K7|uniprotkb:Q8N4C2|uniprotkb:Q96MJ7|uniprotkb:Q9BY20|ensembl:ENSP00000263925	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:lnx1_human(display_long)|uniprotkb:LNX1(gene name)|psi-mi:LNX1(display_short)|uniprotkb:LNX(gene name synonym)|uniprotkb:Numb-binding protein 1(gene name synonym)|uniprotkb:Ligand of Numb-protein X 1(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 2(gene name synonym)|uniprotkb:PDZRN2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase LNX(gene name synonym)|uniprotkb:UNQ574/PRO1136(orf name)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702072|imex:IM-22632-769	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119800.1|refseq:NP_116011.2|refseq:XP_005265842.1|refseq:XP_016864265.1|ensembl:ENSG00000072201(gene)|ensembl:ENST00000263925(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8TBB1|rcsb pdb:3B76|rcsb pdb:5H7R|rcsb pdb:5H7S|reactome:R-HSA-983168|refseq:NM_001126328.2(identity)|entrezgene/locuslink:84708(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:tWvePnVxh9yxWl8nQd3KZhCSKKo9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:5962836FEE2709ED|rigid:WXVPQEYlTE2GWxAdAQu+5JJhrlQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:Q6ZMI0	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-5235703|uniprotkb:B7ZKY5|uniprotkb:Q2TA78|uniprotkb:Q6ZMI6|uniprotkb:Q8IW83|uniprotkb:Q8J029|uniprotkb:Q96ES8|uniprotkb:B7ZKY7|uniprotkb:E1B6W7|ensembl:ENSP00000294952	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:ppr21_human(display_long)|uniprotkb:PPP1R21(gene name)|psi-mi:PPP1R21(display_short)|uniprotkb:CCDC128(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 128(gene name synonym)|uniprotkb:KLRAQ motif-containing protein 1(gene name synonym)|uniprotkb:KLRAQ1(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702061|imex:IM-22632-768	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	refseq:NP_001129101.1|refseq:NP_001180404.1|refseq:NP_694539.1|ensembl:ENSG00000162869(gene)|ensembl:ENST00000294952(transcript)|go:"GO:0005769"(early endosome)|go:"GO:0016020"(membrane)|interpro:IPR019343|interpro:IPR019348|interpro:IPR040024|entrezgene/locuslink:129285(identity)|refseq:NM_001193475.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:cp4v9NF+YVUYq0eABVb/gj0TeJA9606	intact-crc:B2A2C2407EBE00B3|rigid:lv29AE/OtNJ2bhXo9ASGwkWjpJg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96IP4	uniprotkb:Q9NP31	intact:EBI-954084|uniprotkb:Q5TF86|uniprotkb:Q8NFZ9|uniprotkb:Q9BW32|uniprotkb:Q9NXV5|uniprotkb:A8K7U4|ensembl:ENSP00000318298	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:tet5a_human(display_long)|uniprotkb:TENT5A(gene name)|psi-mi:TENT5A(display_short)|uniprotkb:C6orf37(gene name synonym)|uniprotkb:FAM46A(gene name synonym)|uniprotkb:HBV X-transactivated gene 11 protein(gene name synonym)|uniprotkb:HBV XAg-transactivated protein 11(gene name synonym)|uniprotkb:XTP11(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702083|imex:IM-22632-770	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060103.2|ensembl:ENSG00000112773(gene)|ensembl:ENST00000320172(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0048255"(mRNA stabilization)|go:"GO:1990817"(RNA adenylyltransferase activity)|interpro:IPR012937(Protein of unknown function DUF1693)|entrezgene/locuslink:55603(identity)|refseq:NM_017633.2(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:RoYW7NusMegWdnScxOvz6GI6Kjo9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:C77D5E815D8A2FBD|rigid:S/ydXptquYVA2toac2ye1abZYMc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:Q9UKG1	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702094|imex:IM-22632-771	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:41D0A25F6BD15C91|rigid:jY22HffVts37wBZshubd31F8SJ0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05397	uniprotkb:Q9NP31	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702116|imex:IM-22632-773	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BLK (P51451), FGR (P09769), FYN (P06241), HCK (P08631), SRC (P12931), SYK (P43405), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:E706336896D27764|rigid:Nrlu/4OZupxaxYihwZVPX+DqP7w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:Q9Y575	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-2875625|ensembl:ENSP00000263634|ensembl:ENSP00000385085|uniprotkb:Q53TN8|uniprotkb:Q53TN0|uniprotkb:B3KPA3|uniprotkb:Q9NVZ2|uniprotkb:D6W5B4|uniprotkb:D6W5B5|uniprotkb:G8JLA9|uniprotkb:Q2TAI4	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:asb3_human(display_long)|uniprotkb:ASB3(gene name)|psi-mi:ASB3(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702105|imex:IM-22632-772	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	go:"GO:0030315"(T-tubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0055117"(regulation of cardiac muscle contraction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036036|interpro:IPR036770|interpro:IPR037329|mint:Q9Y575|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000115239(gene)|ensembl:ENST00000263634(transcript)|ensembl:ENST00000406625(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|refseq:NP_001188894.1|refseq:NP_057199.1|refseq:NP_665862.1|refseq:NP_001157637.1|refseq:NM_016115.4(identity)|entrezgene/locuslink:51130(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:gIMKRtUzf90UdaMhaSwEmesN+KE9606	intact-crc:7F0DED9CA3383469|rigid:ByIH+zvsNIh3dHDQU9Mo6PRF7kw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H706	uniprotkb:P46108	intact:EBI-3440103|uniprotkb:Q0VAG3|uniprotkb:Q9BSF5|uniprotkb:Q8ND03|uniprotkb:Q0VAG4|intact:EBI-28975682|ensembl:ENSP00000269209	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:gare1_human(display_long)|uniprotkb:GAREM1(gene name)|psi-mi:GAREM1(display_short)|uniprotkb:C18orf11(gene name synonym)|uniprotkb:FAM59A(gene name synonym)|uniprotkb:GAREM(gene name synonym)|uniprotkb:GRB2-associated and regulator of MAPK1(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702138|imex:IM-22632-775	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000269209|ensembl:ENST00000399218|ensembl:ENSP00000382165|refseq:NP_001229338.1|refseq:NP_073588.1|ensembl:ENSG00000141441(gene)|ensembl:ENST00000269209(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR025946|rcsb pdb:2DKZ|entrezgene/locuslink:64762(identity)|refseq:NM_001242409.1(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:QEmdhomnnbwOJjOYfPZptJdHqbA9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:84B4FA28CF19CF5A|rigid:hiTRaJyzha/h+ZzETOmC9WjPb48	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H706	uniprotkb:P46108-2	intact:EBI-3440103|uniprotkb:Q0VAG3|uniprotkb:Q9BSF5|uniprotkb:Q8ND03|uniprotkb:Q0VAG4|intact:EBI-28975682|ensembl:ENSP00000269209	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:gare1_human(display_long)|uniprotkb:GAREM1(gene name)|psi-mi:GAREM1(display_short)|uniprotkb:C18orf11(gene name synonym)|uniprotkb:FAM59A(gene name synonym)|uniprotkb:GAREM(gene name synonym)|uniprotkb:GRB2-associated and regulator of MAPK1(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702127|imex:IM-22632-774	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000269209|ensembl:ENST00000399218|ensembl:ENSP00000382165|refseq:NP_001229338.1|refseq:NP_073588.1|ensembl:ENSG00000141441(gene)|ensembl:ENST00000269209(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR025946|rcsb pdb:2DKZ|entrezgene/locuslink:64762(identity)|refseq:NM_001242409.1(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:QEmdhomnnbwOJjOYfPZptJdHqbA9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:16D6B2B4863EC588|rigid:NNrh7DgkEMl/fxsH1ZpHowU6Gv8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H3H1-2	uniprotkb:Q5VZ18	intact:EBI-10693345	intact:EBI-3956977|uniprotkb:Q8TEQ5|ensembl:ENSP00000307369	psi-mi:q9h3h1-2(display_long)|uniprotkb:tRNA isopentenyltransferase 1(gene name synonym)|uniprotkb:TRIT1(gene name)|psi-mi:TRIT1(display_short)|uniprotkb:IPT(gene name synonym)|uniprotkb:"Isopentenyl-diphosphate:tRNA isopentenyltransferase"(gene name synonym)|uniprotkb:MOD5(gene name synonym)|uniprotkb:hGRO1(gene name synonym)	psi-mi:she_human(display_long)|uniprotkb:SHE(gene name)|psi-mi:SHE(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702160|imex:IM-22632-777	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-720913(isoform-parent)|refseq:XM_006710706.1(identity)|entrezgene/locuslink:54802(identity)	refseq:XP_011507465.1|refseq:NP_001010846.1|ensembl:ENSG00000169291(gene)|ensembl:ENST00000304760(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|interpro:IPR000980(SH2 motif)|interpro:IPR035041|interpro:IPR035042|interpro:IPR036860|entrezgene/locuslink:126669(identity)|refseq:NM_001010846.2(identity)	-	isoform-comment:No experimental confirmation available.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:99w7Wm+fBfaBVAbobo5LmutMLgg9606	rogid:ZN2ORmTe7ETaKpdPvYPJP3yQKbI9606	intact-crc:BDB8691B5AA2EDAF|rigid:Zre1SKSHQ8VA7Fx2GZFxrVdhBzg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H4I2-2	uniprotkb:Q9NP31	intact:EBI-10693326|ensembl:ENSP00000443783	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:q9h4i2-2(display_long)|uniprotkb:ZHX3(gene name)|psi-mi:ZHX3(display_short)|uniprotkb:KIAA0395(gene name synonym)|uniprotkb:TIX1(gene name synonym)|uniprotkb:Triple homeobox protein 1(gene name synonym)|uniprotkb:Zinc finger and homeodomain protein 3(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702149|imex:IM-22632-776	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000174306(gene)|ensembl:ENST00000544979(transcript)|intact:EBI-948582(isoform-parent)|uniprotkb:Q9H4I2-2(isoform-parent)|refseq:XM_005260341.2(identity)|entrezgene/locuslink:23051(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	isoform-comment:No experimental confirmation available.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:l8isziiF3UQqrddT+mTWDc0ZBGk9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:00D4E1E0C760DA22|rigid:Wd4F+qZBMffHDjLsLGt5MlTHXy0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H0V1	uniprotkb:P46109	intact:EBI-10691967|uniprotkb:Q8NEK4|uniprotkb:B4DDS0|uniprotkb:A4D0T9|uniprotkb:Q9H8J2|ensembl:ENSP00000323068|ensembl:ENSP00000390696	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	psi-mi:tm168_human(display_long)|uniprotkb:TMEM168(gene name)|psi-mi:TMEM168(display_short)	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702171|imex:IM-22632-778	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001274426.1|refseq:NP_071929.3|ensembl:ENSG00000146802(gene)|ensembl:ENST00000312814(transcript)|ensembl:ENST00000454074(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|interpro:IPR029713|refseq:XP_016868012.1|refseq:XP_016868014.1|refseq:NM_022484.5(identity)|entrezgene/locuslink:64418(identity)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|entrezgene/locuslink:1399(identity)|refseq:NM_005207.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SnJHXvhXT7kCxoT+82XkdTiSySY9606	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	intact-crc:70D9A0296D398361|rigid:DrFOfcIXi90bXuuCXhWU80ZdnsM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BYZ2	uniprotkb:Q96JZ2	intact:EBI-1108377|uniprotkb:Q6DUY4|uniprotkb:Q96LI2|ensembl:ENSP00000302393	intact:EBI-3919324|intact:EBI-28973686|ensembl:ENSP00000482604|ensembl:ENSP00000483354|uniprotkb:B5ME72|uniprotkb:Q6ZNG7	psi-mi:ldh6b_human(display_long)|uniprotkb:LDHAL6B(gene name)|psi-mi:LDHAL6B(display_short)|uniprotkb:LDHAL6(gene name synonym)|uniprotkb:LDHL(gene name synonym)	psi-mi:hsh2d_human(display_long)|uniprotkb:HSH2D(gene name)|psi-mi:HSH2D(display_short)|uniprotkb:ALX(gene name synonym)|uniprotkb:Adaptor in lymphocytes of unknown function X(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702182|imex:IM-22632-779	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000171989(gene)|ensembl:ENST00000307144(transcript)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:Q9BYZ2|reactome:R-HSA-70268|refseq:NP_149972.1|entrezgene/locuslink:92483(identity)|refseq:NM_033195.2(identity)	ensembl:ENSP00000483354|ensembl:ENSP00000482604|ensembl:ENSG00000196684(gene)|ensembl:ENST00000613986(transcript)|ensembl:ENST00000616645(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR035047|interpro:IPR036860|rcsb pdb:2CS0|go:"GO:0005737"(cytoplasm)|refseq:NP_116244.1|refseq:NP_001278203.1|refseq:NM_032855.3(identity)|entrezgene/locuslink:84941(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:VktHnjwxkeayt64SWFxLAq4YlLQ9606	rogid:Y01YjkfU/oOtbz2TdQcnm+lBWhs9606	intact-crc:CEA480E4297F3B52|rigid:JAY+AW05djmvicy7NmCmLW3qGYw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXM7	uniprotkb:Q96JZ2	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	intact:EBI-3919324|intact:EBI-28973686|ensembl:ENSP00000482604|ensembl:ENSP00000483354|uniprotkb:B5ME72|uniprotkb:Q6ZNG7	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:hsh2d_human(display_long)|uniprotkb:HSH2D(gene name)|psi-mi:HSH2D(display_short)|uniprotkb:ALX(gene name synonym)|uniprotkb:Adaptor in lymphocytes of unknown function X(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702193|imex:IM-22632-780	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N|entrezgene/locuslink:65018(identity)|refseq:NM_032409.2(identity)	ensembl:ENSP00000483354|ensembl:ENSP00000482604|ensembl:ENSG00000196684(gene)|ensembl:ENST00000613986(transcript)|ensembl:ENST00000616645(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR035047|interpro:IPR036860|rcsb pdb:2CS0|go:"GO:0005737"(cytoplasm)|refseq:NP_116244.1|refseq:NP_001278203.1|refseq:NM_032855.3(identity)|entrezgene/locuslink:84941(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	rogid:Y01YjkfU/oOtbz2TdQcnm+lBWhs9606	intact-crc:7F4FE48A43B3356D|rigid:z42I50QT56RmfOYvTXzX/awdpYs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEU8	uniprotkb:Q9BVC4	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	intact:EBI-1387471|intact:EBI-1567843|uniprotkb:Q5M800|uniprotkb:Q86Y18|uniprotkb:Q8WUI5|uniprotkb:Q9HA66|uniprotkb:Q9UJV6|uniprotkb:B4DY00|uniprotkb:B3KMM4|uniprotkb:D3DU88|ensembl:ENSP00000380313|ensembl:ENSP00000455046|ensembl:ENSP00000456405|ensembl:ENSP00000457870	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:lst8_human(display_long)|uniprotkb:MLST8(gene name)|psi-mi:MLST8(display_short)|uniprotkb:GBL(gene name synonym)|uniprotkb:G protein beta subunit-like(gene name synonym)|uniprotkb:LST8(gene name synonym)|uniprotkb:Mammalian lethal with SEC13 protein 8(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702204|imex:IM-22632-781	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	refseq:NP_001186102.1|refseq:NP_001186103.1|refseq:NP_001186104.1|refseq:NP_071767.3|refseq:XP_016879037.1|refseq:XP_016879038.1|dip:DIP-39481N|ensembl:ENSG00000167965(gene)|ensembl:ENST00000397124(transcript)|ensembl:ENST00000564088(transcript)|ensembl:ENST00000565250(transcript)|ensembl:ENST00000569417(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR037588|mint:Q9BVC4|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5H64|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288|entrezgene/locuslink:64223(identity)|refseq:XM_005255480.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	rogid:BQek96xYe/1IaE8vgX3Uvl9vkCc9606	intact-crc:8454CF4FD416CFD6|rigid:PFCZKZDHwDIYbxWdclyrjH68zRw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q9BS75	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-10693436|intact:EBI-12812735	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:q9bs75_human(display_long)|uniprotkb:KLHL20(gene name)|psi-mi:KLHL20(display_short)|uniprotkb:hCG_23698(orf name)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702215|imex:IM-22632-782	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|entrezgene/locuslink:27252(identity)|refseq:NM_014458.3(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:CkJiQXWRaKpssKC+1jEOsq4s2PA9606	intact-crc:F822142035B27E31|rigid:jUJZTr6+FXfTdYfXrA9DxIaYkkM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99704	uniprotkb:P46109	intact:EBI-1384360|uniprotkb:O43204|uniprotkb:Q53TY2|uniprotkb:Q9UHG6|ensembl:ENSP00000233668	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	psi-mi:dok1_human(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:pp62(gene name synonym)|uniprotkb:DOK1(gene name)|psi-mi:DOK1(display_short)	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702226|imex:IM-22632-783	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001184189.1|refseq:NP_001372.1|refseq:NP_001305797.1|ensembl:ENSG00000115325(gene)|ensembl:ENST00000233668(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:Q99704|rcsb pdb:2V76|reactome:R-HSA-8849469|reactome:R-HSA-8853659|refseq:NM_001381.3(identity)|entrezgene/locuslink:1796(identity)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|entrezgene/locuslink:1399(identity)|refseq:NM_005207.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:Pvjez+wIa3gWdY9ZYvWN6lmOM4o9606	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	intact-crc:B3A03DD374464C8E|rigid:SvJ4njZUxhYuzvvqDwTDjfTHjsA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99645	uniprotkb:P46108	intact:EBI-6677336|ensembl:ENSP00000261172|uniprotkb:A8K3M7|uniprotkb:Q8NEJ5	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:epyc_human(display_long)|uniprotkb:EPYC(gene name)|psi-mi:EPYC(display_short)|uniprotkb:DSPG3(gene name synonym)|uniprotkb:PGLB(gene name synonym)|uniprotkb:SLRR3B(gene name synonym)|uniprotkb:Dermatan sulfate proteoglycan 3(gene name synonym)|uniprotkb:Proteoglycan-Lb(gene name synonym)|uniprotkb:Small chondroitin/dermatan sulfate proteoglycan(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702237|imex:IM-22632-784	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083782(gene)|ensembl:ENST00000261172(transcript)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0031012"(extracellular matrix)|go:"GO:0060348"(bone development)|go:"GO:0061975"(articular cartilage development)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027217|interpro:IPR032675|interpro:IPR043547|refseq:NP_004941.2|refseq:NM_004950.4(identity)|entrezgene/locuslink:1833(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:1qzc4zJzP7s4IHAGdKeYCcWtEjs9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:056D9368B3DCCE2F|rigid:bJdVRLZFMpN/rqf2dXQAoQIhMeM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q99504	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-9089567|uniprotkb:Q99813|uniprotkb:O95463|uniprotkb:A8K190|uniprotkb:B4DIR7|uniprotkb:B4DNZ7|uniprotkb:Q8IVX7|ensembl:ENSP00000362978	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:eya3_human(display_long)|uniprotkb:EYA3(gene name)|psi-mi:EYA3(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702259|imex:IM-22632-786	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_001981.2|ensembl:ENST00000373863|ensembl:ENSP00000362970|ensembl:ENSP00000362978|ensembl:ENST00000436342|ensembl:ENSP00000405587|ensembl:ENST00000540618|ensembl:ENSP00000442558|refseq:NP_001269489.1|refseq:NP_001269490.1|refseq:NP_001269491.1|dip:DIP-60448N|ensembl:ENSG00000158161(gene)|ensembl:ENST00000373871(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007601"(visual perception)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0048856"(anatomical structure development)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR006545(EYA)|interpro:IPR028472|interpro:IPR028479|interpro:IPR038102|interpro:IPR042577|reactome:R-HSA-5693565|refseq:NM_001990.3(identity)|entrezgene/locuslink:2140(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:FrzkCC1XK5NDTbrxH25HEKcj5P89606	intact-crc:865F66272E1CD389|rigid:oyRDJXn2jqU0gc326a/KoxE+EG0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99619	uniprotkb:Q92569	intact:EBI-2323209|uniprotkb:D3DUT0|uniprotkb:B7Z4W1|ensembl:ENSP00000428338|ensembl:ENSP00000430872	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:spsb2_human(display_long)|uniprotkb:SPSB2(gene name)|psi-mi:SPSB2(display_short)|uniprotkb:GRCC9(gene name synonym)|uniprotkb:SSB2(gene name synonym)|uniprotkb:Gene-rich cluster protein C9(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702248|imex:IM-22632-785	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139788.1|refseq:NP_116030.1|refseq:NP_001306599.1|ensembl:ENSG00000111671(gene)|ensembl:ENST00000523102(transcript)|ensembl:ENST00000524270(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036036|interpro:IPR037340|interpro:IPR043136|mint:Q99619|rcsb pdb:3EMW|rcsb pdb:5XN3|rcsb pdb:6DN5|rcsb pdb:6DN6|rcsb pdb:6JKJ|rcsb pdb:6JWM|rcsb pdb:6JWN|rcsb pdb:6KEY|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NM_001146316.1(identity)|entrezgene/locuslink:84727(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FES (P07332)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:d9ATBVBuRYT4OE5DV+pjGasS9qs9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:997FE9B6AD87ECBC|rigid:FD/bq5YQHQ4pqVjedrPniNx9GTs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q96R05	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-2856326|uniprotkb:B2R517|uniprotkb:Q5SWJ4|ensembl:ENSP00000294435	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:ret7_human(display_long)|uniprotkb:RBP7(gene name)|psi-mi:RBP7(display_short)|uniprotkb:Cellular retinoic acid-binding protein 4(gene name synonym)|uniprotkb:Cellular retinoic acid-binding protein IV(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702270|imex:IM-22632-787	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_443192.1|interpro:IPR031259|rcsb pdb:1LPJ|rcsb pdb:6AT8|rcsb pdb:6E6K|ensembl:ENSG00000162444(gene)|ensembl:ENST00000294435(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016918"(retinal binding)|go:"GO:0019841"(retinol binding)|interpro:IPR000463(Cytosolic fatty-acid binding)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|entrezgene/locuslink:116362(identity)|refseq:NM_052960.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:75axWxV5mnxExd1avjdlOUK4o2E9606	intact-crc:4E5D54417096B80E|rigid:GQJdy08m0L8IK7bXQLHqKjbuRLo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96JZ2	uniprotkb:Q96R05	intact:EBI-3919324|intact:EBI-28973686|ensembl:ENSP00000482604|ensembl:ENSP00000483354|uniprotkb:B5ME72|uniprotkb:Q6ZNG7	intact:EBI-2856326|uniprotkb:B2R517|uniprotkb:Q5SWJ4|ensembl:ENSP00000294435	psi-mi:hsh2d_human(display_long)|uniprotkb:HSH2D(gene name)|psi-mi:HSH2D(display_short)|uniprotkb:ALX(gene name synonym)|uniprotkb:Adaptor in lymphocytes of unknown function X(gene name synonym)	psi-mi:ret7_human(display_long)|uniprotkb:RBP7(gene name)|psi-mi:RBP7(display_short)|uniprotkb:Cellular retinoic acid-binding protein 4(gene name synonym)|uniprotkb:Cellular retinoic acid-binding protein IV(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702281|imex:IM-22632-788	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000483354|ensembl:ENSP00000482604|ensembl:ENSG00000196684(gene)|ensembl:ENST00000613986(transcript)|ensembl:ENST00000616645(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR035047|interpro:IPR036860|rcsb pdb:2CS0|go:"GO:0005737"(cytoplasm)|refseq:NP_116244.1|refseq:NP_001278203.1|refseq:NM_032855.3(identity)|entrezgene/locuslink:84941(identity)	refseq:NP_443192.1|interpro:IPR031259|rcsb pdb:1LPJ|rcsb pdb:6AT8|rcsb pdb:6E6K|ensembl:ENSG00000162444(gene)|ensembl:ENST00000294435(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016918"(retinal binding)|go:"GO:0019841"(retinol binding)|interpro:IPR000463(Cytosolic fatty-acid binding)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|entrezgene/locuslink:116362(identity)|refseq:NM_052960.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Y01YjkfU/oOtbz2TdQcnm+lBWhs9606	rogid:75axWxV5mnxExd1avjdlOUK4o2E9606	intact-crc:F73259365F048F52|rigid:+zOloOwpu0WOONy4r7Lv6VuWcts	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BSQ5	uniprotkb:Q96N03	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	intact:EBI-948213|uniprotkb:Q5JWZ4|uniprotkb:Q5JWZ5|uniprotkb:Q8ND45|uniprotkb:Q9BR37|uniprotkb:E1P5V7|ensembl:ENSP00000362560	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:vtm2l_human(display_long)|uniprotkb:C20orf102(gene name synonym)|uniprotkb:VSTM2L(gene name)|psi-mi:VSTM2L(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702292|imex:IM-22632-789	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N|refseq:NM_031443.3(identity)|entrezgene/locuslink:83605(identity)	refseq:NP_542174.1|ensembl:ENSG00000132821(gene)|ensembl:ENST00000373461(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0030424"(axon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR027115|interpro:IPR036179|refseq:NM_080607.2(identity)|entrezgene/locuslink:128434(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	rogid:CMZ06pQwq1ob76PkF0ZdxdLJwwY9606	intact-crc:70BE58645F7001B5|rigid:OW4hbb06Irg1xw9KD15p/94GzrU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763-2	uniprotkb:Q96JC1	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	intact:EBI-1050197|uniprotkb:O94869|uniprotkb:Q7Z3V3|uniprotkb:Q96B93|uniprotkb:Q96RM0|uniprotkb:Q71SQ6|ensembl:ENSP00000335193	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:vps39_human(display_long)|uniprotkb:KIAA0770(gene name synonym)|uniprotkb:VPS39(gene name)|psi-mi:VPS39(display_short)|uniprotkb:VAM6(gene name synonym)|uniprotkb:TLP(gene name synonym)|uniprotkb:TRAP1-like protein(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702314|imex:IM-22632-791	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_056104.2|refseq:NP_001288067.1|ensembl:ENSG00000166887(gene)|ensembl:ENST00000348544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:1902501"(lysosomal HOPS complex)|go:"GO:1902774"(late endosome to lysosome transport)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR001180(Citron-like)|interpro:IPR019452|interpro:IPR019453|interpro:IPR032914|rcsb pdb:6ZE9|refseq:NM_015289.3(identity)|entrezgene/locuslink:23339(identity)	-	isoform-comment:Contains a phosphotyrosine at position 704.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	rogid:BeY8ZDCOyTvZqA0WpdWnmz+giYk9606	intact-crc:E127F426AD42276F|rigid:u53/MnD2QnTipHM00E5zREmeZaQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q96JZ2	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-3919324|intact:EBI-28973686|ensembl:ENSP00000482604|ensembl:ENSP00000483354|uniprotkb:B5ME72|uniprotkb:Q6ZNG7	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:hsh2d_human(display_long)|uniprotkb:HSH2D(gene name)|psi-mi:HSH2D(display_short)|uniprotkb:ALX(gene name synonym)|uniprotkb:Adaptor in lymphocytes of unknown function X(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702303|imex:IM-22632-790	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	ensembl:ENSP00000483354|ensembl:ENSP00000482604|ensembl:ENSG00000196684(gene)|ensembl:ENST00000613986(transcript)|ensembl:ENST00000616645(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR035047|interpro:IPR036860|rcsb pdb:2CS0|go:"GO:0005737"(cytoplasm)|refseq:NP_116244.1|refseq:NP_001278203.1|refseq:NM_032855.3(identity)|entrezgene/locuslink:84941(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:Y01YjkfU/oOtbz2TdQcnm+lBWhs9606	intact-crc:172BBC2D15343ACE|rigid:F+rZoM6yRSGHwcQY2FV9Vt+zNpI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HC96	uniprotkb:Q96IW2	intact:EBI-3915761|uniprotkb:Q8NCD4|uniprotkb:Q9HC90|uniprotkb:Q9HC95|uniprotkb:Q4ZFV1|uniprotkb:Q96JI2|uniprotkb:A8MVS7|uniprotkb:Q9HC94|uniprotkb:Q96IG4|uniprotkb:Q9HC89|uniprotkb:Q9HC92|uniprotkb:Q9HC91|uniprotkb:Q9HC93|ensembl:ENSP00000375844	intact:EBI-4402781|uniprotkb:Q96NC2|ensembl:ENSP00000446058	psi-mi:can10_human(display_long)|uniprotkb:CAPN10(gene name)|psi-mi:CAPN10(display_short)|uniprotkb:KIAA1845(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 10(gene name synonym)	psi-mi:shd_human(display_long)|uniprotkb:SHD(gene name)|psi-mi:SHD(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702336|imex:IM-22632-793	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075571.1|refseq:NP_075573.2|ensembl:ENSG00000142330(gene)|ensembl:ENST00000391984(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006921"(cellular component disassembly involved in execution phase of apoptosis)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR028791|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|reactome:R-HSA-1474228|entrezgene/locuslink:11132(identity)|refseq:NM_023083.3(identity)	refseq:NP_064594.3|ensembl:ENSG00000105251(gene)|go:"GO:0001784"(phosphotyrosine residue binding)|interpro:IPR000980(SH2 motif)|interpro:IPR035039|interpro:IPR035046|interpro:IPR036860|ensembl:ENST00000543264(transcript)|entrezgene/locuslink:56961(identity)|refseq:NM_020209.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:qXRiuthkIdLlLN+Fm5tPitkirMc9606	rogid:c2PsXxVdBB1dLj+Lu40XdgOb2yY9606	intact-crc:C686D3F06ED951A1|rigid:UBgxiKSM5LF8kQxkNVSRGIlUfd8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96IW2	uniprotkb:A0A024R0L9	intact:EBI-4402781|uniprotkb:Q96NC2|ensembl:ENSP00000446058	intact:EBI-10696468	psi-mi:shd_human(display_long)|uniprotkb:SHD(gene name)|psi-mi:SHD(display_short)	psi-mi:a0a024r0l9_human(display_long)|uniprotkb:PSG11(gene name)|psi-mi:PSG11(display_short)|uniprotkb:hCG_1995685(orf name)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702325|imex:IM-22632-792	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064594.3|ensembl:ENSG00000105251(gene)|go:"GO:0001784"(phosphotyrosine residue binding)|interpro:IPR000980(SH2 motif)|interpro:IPR035039|interpro:IPR035046|interpro:IPR036860|ensembl:ENST00000543264(transcript)|entrezgene/locuslink:56961(identity)|refseq:NM_020209.3(identity)	interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|refseq:NM_001113410.1(identity)|entrezgene/locuslink:5680(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:c2PsXxVdBB1dLj+Lu40XdgOb2yY9606	rogid:+Zxvf2yKA3sKqk9Qc1bnHjpiGdE9606	intact-crc:242EBEBBEF4E1B6E|rigid:PslGsUwyIOpsMH0bLVHJcyT85DM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12929	uniprotkb:Q96GT9	intact:EBI-375576|uniprotkb:A6NMC3|ensembl:ENSP00000281172|ensembl:ENSP00000441867|ensembl:ENSP00000442388|ensembl:ENSP00000494689|ensembl:ENSP00000494842|ensembl:ENSP00000495722|ensembl:ENSP00000495824|ensembl:ENSP00000495956|ensembl:ENSP00000496406|ensembl:ENSP00000496516|uniprotkb:Q8N6J0|uniprotkb:B4DX66|uniprotkb:A8K6W2|uniprotkb:A8KA66	intact:EBI-750167|uniprotkb:Q5HYR4|ensembl:ENSP00000286049	psi-mi:eps8_human(display_long)|uniprotkb:EPS8(gene name)|psi-mi:EPS8(display_short)	psi-mi:xage2_human(display_long)|uniprotkb:Cancer/testis antigen 12.2(gene name synonym)|uniprotkb:XAGE2(gene name)|psi-mi:XAGE2(display_short)|uniprotkb:GAGED3(gene name synonym)|uniprotkb:G antigen family D member 3(gene name synonym)|uniprotkb:XAGE2B(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702347|imex:IM-22632-794	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000645775(transcript)|ensembl:ENST00000646828(transcript)|ensembl:ENSG00000151491(gene)|ensembl:ENST00000646918(transcript)|ensembl:ENST00000647087(transcript)|ensembl:ENST00000647224(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010458"(exit from mitosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0030426"(growth cone)|go:"GO:0030832"(regulation of actin filament length)|go:"GO:0031267"(small GTPase binding)|ensembl:ENST00000281172(transcript)|ensembl:ENST00000543523(transcript)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|ensembl:ENST00000543612(transcript)|ensembl:ENST00000642278(transcript)|ensembl:ENST00000644374(transcript)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030222|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q12929|rcsb pdb:2E8M|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_004438.3|dip:DIP-32859N|entrezgene/locuslink:2059(identity)|refseq:NM_004447.5(identity)	refseq:NP_570133.1|refseq:XP_011529138.1|ensembl:ENSG00000155622(gene)|ensembl:ENST00000286049(transcript)|interpro:IPR008625(GAGE)|interpro:IPR031320|entrezgene/locuslink:728242(identity)|refseq:NM_130777.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ulBgb+4uZ7XrN4bLogRtd9I5AbY9606	rogid:oEfLIl6RmCLabVT5MZpMg6uxBXk9606	intact-crc:6CA4845AC1DCF999|rigid:kDtfk1DIrao3Zy/e7kb5OSNAh5o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96DZ7	uniprotkb:P40763-2	intact:EBI-6448756|ensembl:ENSP00000273695|uniprotkb:E9PH22|uniprotkb:B2RV20|uniprotkb:Q336K7	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:t4s19_human(display_long)|uniprotkb:Osteoclast maturation-associated gene 4 protein(gene name synonym)|uniprotkb:Tetraspan membrane protein OCTM4(gene name synonym)|uniprotkb:TM4SF19(gene name)|psi-mi:TM4SF19(display_short)|uniprotkb:OCTM4(gene name synonym)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702358|imex:IM-22632-795	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145107(gene)|ensembl:ENST00000273695(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008661(L6 membrane)|refseq:NP_001191827.1|refseq:NP_612470.2|refseq:NM_138461.3(identity)|entrezgene/locuslink:116211(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	-	isoform-comment:Contains a phosphotyrosine at position 704.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:0pi3aVpxzi5UX4o8+w7qSluVefU9606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:745F439AF9DA4910|rigid:32u/GAeQSnHLfMfuScxzr2Oz/V0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96DZ7	uniprotkb:P40763	intact:EBI-6448756|ensembl:ENSP00000273695|uniprotkb:E9PH22|uniprotkb:B2RV20|uniprotkb:Q336K7	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:t4s19_human(display_long)|uniprotkb:Osteoclast maturation-associated gene 4 protein(gene name synonym)|uniprotkb:Tetraspan membrane protein OCTM4(gene name synonym)|uniprotkb:TM4SF19(gene name)|psi-mi:TM4SF19(display_short)|uniprotkb:OCTM4(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702369|imex:IM-22632-796	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145107(gene)|ensembl:ENST00000273695(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008661(L6 membrane)|refseq:NP_001191827.1|refseq:NP_612470.2|refseq:NM_138461.3(identity)|entrezgene/locuslink:116211(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:0pi3aVpxzi5UX4o8+w7qSluVefU9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:8FF97560A3ADFC52|rigid:nkbM5+A8K0W7BIL/VMRbnL8E3ew	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96DZ7	uniprotkb:P46108-2	intact:EBI-6448756|ensembl:ENSP00000273695|uniprotkb:E9PH22|uniprotkb:B2RV20|uniprotkb:Q336K7	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:t4s19_human(display_long)|uniprotkb:Osteoclast maturation-associated gene 4 protein(gene name synonym)|uniprotkb:Tetraspan membrane protein OCTM4(gene name synonym)|uniprotkb:TM4SF19(gene name)|psi-mi:TM4SF19(display_short)|uniprotkb:OCTM4(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702380|imex:IM-22632-797	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145107(gene)|ensembl:ENST00000273695(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008661(L6 membrane)|refseq:NP_001191827.1|refseq:NP_612470.2|refseq:NM_138461.3(identity)|entrezgene/locuslink:116211(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:0pi3aVpxzi5UX4o8+w7qSluVefU9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:54722B9CE0CD08F7|rigid:yrwSRn43USuHqynsW2FoitXpcoI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q92854	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-2855119|uniprotkb:Q7Z5S4|uniprotkb:B2RPM6|uniprotkb:Q8N8B0|ensembl:ENSP00000348822|ensembl:ENSP00000388768|ensembl:ENSP00000405102|ensembl:ENSP00000416523	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:sem4d_human(display_long)|uniprotkb:SEMA4D(gene name)|psi-mi:SEMA4D(display_short)|uniprotkb:C9orf164(gene name synonym)|uniprotkb:CD100(gene name synonym)|uniprotkb:SEMAJ(gene name synonym)|uniprotkb:A8(gene name synonym)|uniprotkb:BB18(gene name synonym)|uniprotkb:GR3(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702391|imex:IM-22632-798	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:XP_011516425.1|refseq:XP_011516436.1|refseq:XP_011516426.1|refseq:XP_011516427.1|refseq:XP_011516429.1|refseq:XP_011516430.1|refseq:XP_011516431.1|refseq:XP_011516432.1|refseq:XP_011516433.1|refseq:XP_011516435.1|refseq:XP_016869682.1|refseq:XP_016869683.1|refseq:XP_016869684.1|refseq:XP_016869685.1|refseq:XP_016869686.1|refseq:XP_016869687.1|refseq:NP_001135759.1|refseq:NP_006369.3|refseq:XP_005251711.1|dip:DIP-59221N|ensembl:ENSG00000187764(gene)|ensembl:ENST00000356444(transcript)|ensembl:ENST00000422704(transcript)|ensembl:ENST00000438547(transcript)|ensembl:ENST00000450295(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031344"(regulation of cell projection organization)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0070486"(leukocyte aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1900220"(semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis)|go:"GO:1905704"(positive regulation of inhibitory synapse assembly)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|rcsb pdb:1OLZ|rcsb pdb:3OL2|reactome:R-HSA-416550|reactome:R-HSA-416572|reactome:R-HSA-416700|refseq:NM_006378.3(identity)|entrezgene/locuslink:10507(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:2Xa00fuwt0CCvnzXwe5Q0ukApRc9606	intact-crc:46D01A0AA7B9EF3C|rigid:4aALD4CzRV8/tYYuTsGFXsS1JZw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:Q92574	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702402|imex:IM-22632-799	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1|entrezgene/locuslink:7248(identity)|refseq:NM_001162426.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:05515706F95A52AE|rigid:sefWc2uB24Pv+L3Bbzz5oRzDcOk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5SXH7	uniprotkb:Q92569	intact:EBI-10691507|uniprotkb:Q6ZQR5|uniprotkb:Q9H5D9|uniprotkb:Q5SXH8|uniprotkb:Q8NE42|uniprotkb:Q5SXI0|uniprotkb:B3KX00|uniprotkb:B6EDE1|uniprotkb:A8KA02|ensembl:ENSP00000354332|ensembl:ENSP00000358316|ensembl:ENSP00000358318|ensembl:ENSP00000483759	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:pkhs1_human(display_long)|uniprotkb:PLEKHS1(gene name)|psi-mi:PLEKHS1(display_short)|uniprotkb:C10orf81(gene name synonym)|uniprotkb:Epididymis luminal protein 185(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702424|imex:IM-22632-801	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001180363.1|refseq:NP_001180364.1|refseq:NP_079165.3|refseq:NP_872407.1|ensembl:ENSG00000148735(gene)|ensembl:ENST00000361048(transcript)|ensembl:ENST00000369310(transcript)|ensembl:ENST00000369312(transcript)|ensembl:ENST00000619563(transcript)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR042986|entrezgene/locuslink:79949(identity)|refseq:XM_005270162.2(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), BMX (P51813), FER (P16591), FES (P07332), FGR (P09769), FRK (P42685), FYN (P06241), HCK (P08631), SRC (P12931), SYK (P43405), TNK1 (Q13470), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2020/10/22	rogid:yEOMXxncrrBHP8H39uEfgZG1c4E9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:C1BCE615D766843E|rigid:ANHdUz4cbq1rPATmKkB2L9JewiA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96JZ2	uniprotkb:Q92574	intact:EBI-3919324|intact:EBI-28973686|ensembl:ENSP00000482604|ensembl:ENSP00000483354|uniprotkb:B5ME72|uniprotkb:Q6ZNG7	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:hsh2d_human(display_long)|uniprotkb:HSH2D(gene name)|psi-mi:HSH2D(display_short)|uniprotkb:ALX(gene name synonym)|uniprotkb:Adaptor in lymphocytes of unknown function X(gene name synonym)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702413|imex:IM-22632-800	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000483354|ensembl:ENSP00000482604|ensembl:ENSG00000196684(gene)|ensembl:ENST00000613986(transcript)|ensembl:ENST00000616645(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR035047|interpro:IPR036860|rcsb pdb:2CS0|go:"GO:0005737"(cytoplasm)|refseq:NP_116244.1|refseq:NP_001278203.1|refseq:NM_032855.3(identity)|entrezgene/locuslink:84941(identity)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1|entrezgene/locuslink:7248(identity)|refseq:NM_001162426.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Y01YjkfU/oOtbz2TdQcnm+lBWhs9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:399A813137682093|rigid:vjugl2c3GydAVGrii2DT/i74kJk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:P35568	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702435|imex:IM-22632-802	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772|refseq:NM_005544.2(identity)|entrezgene/locuslink:3667(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FRK (P42685), FYN (P06241), HCK (P08631), PTK2 (Q05397), SRC (P12931), TNK1 (Q13470), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	intact-crc:F75AA0B373DA5469|rigid:JTCBBkGf9heSVjXJrI8dklyOaoA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:Q92569	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702446|imex:IM-22632-803	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FRK (P42685), FYN (P06241), HCK (P08631), SRC (P12931), SYK (P43405), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:27BE99F7369DC04E|rigid:H45MGP2sseKC/dza30HFhS26Qqg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q49A88	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-751035|intact:EBI-2622203|intact:EBI-2858142|uniprotkb:B7Z2T2|uniprotkb:B8ZZ58|intact:EBI-946963|intact:EBI-1104778|uniprotkb:Q7Z3N3|uniprotkb:Q86T30|uniprotkb:Q8WUJ8|uniprotkb:Q96K47|uniprotkb:Q9H9A3|uniprotkb:Q9UFH0|uniprotkb:Q8IWF8|uniprotkb:B8ZZ41|uniprotkb:D3DN98|uniprotkb:B7Z2Q3	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:ccd14_human(display_long)|uniprotkb:CCDC14(gene name)|psi-mi:CCDC14(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702457|imex:IM-22632-804	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_073594.4|refseq:NP_001295246.1|refseq:XP_005247767.1|refseq:XP_005247768.1|refseq:XP_005247770.1|refseq:XP_005247771.1|refseq:XP_016862545.1|refseq:XP_016862547.1|refseq:XP_016862548.1|mint:Q49A88|dip:DIP-47727N|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0021762"(substantia nigra development)|go:"GO:0034451"(centriolar satellite)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR029343|entrezgene/locuslink:64770(identity)|refseq:XM_005247714.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), SYK (P43405), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:y1bU4io/NA6LIX+pwRkB8gstVuY9606	intact-crc:CC9D130ED82B98E4|rigid:Wh0k/o5KZ3O0oMoO9HL3lUDQdE0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BRX2	uniprotkb:Q92569	intact:EBI-1043580|uniprotkb:Q9GZS6|uniprotkb:Q9Y306|ensembl:ENSP00000274311	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:pelo_human(display_long)|uniprotkb:PELO(gene name)|psi-mi:PELO(display_short)|uniprotkb:CGI-17(orf name)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702468|imex:IM-22632-805	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152684(gene)|ensembl:ENST00000274311(transcript)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007049"(cell cycle)|go:"GO:0007492"(endoderm development)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0070966"(nuclear-transcribed mRNA catabolic process, no-go decay)|go:"GO:0071025"(RNA surveillance)|interpro:IPR004405(Probable translation factor pelota)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR029064|interpro:IPR038069|interpro:IPR042226|mint:Q9BRX2|rcsb pdb:1X52|rcsb pdb:5EO3|rcsb pdb:5LZW|rcsb pdb:5LZX|rcsb pdb:5LZY|rcsb pdb:5LZZ|refseq:NP_057030.3|entrezgene/locuslink:53918(identity)|refseq:NM_015946.4(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FGR (P09769), FYN (P06241), HCK (P08631), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:EZIi8JN2tu0u4oH06fOus3LKjoo9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:5AD5AE4F43444D24|rigid:Y2maO/X3cW2UGVzylwMjrodF1Jg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q03112	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-1384862|uniprotkb:Q16122|uniprotkb:Q99917|uniprotkb:C9JAK0|uniprotkb:Q5HYI1|uniprotkb:Q6MZS6|uniprotkb:Q8NEI5|uniprotkb:A1L4F3|uniprotkb:A8KA00|uniprotkb:B7Z8W7|uniprotkb:B7ZLQ3|uniprotkb:B7ZLQ4|uniprotkb:D3DNP7|ensembl:ENSP00000417899|intact:EBI-8475192|intact:MINT-8417693|uniprotkb:E7EQ57|uniprotkb:Q13465|uniprotkb:Q13466|uniprotkb:Q6FH90	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:mecom_human(display_long)|uniprotkb:MECOM(gene name)|psi-mi:MECOM(display_short)|uniprotkb:EVI1(gene name synonym)|uniprotkb:Ecotropic virus integration site 1 protein homolog(gene name synonym)|uniprotkb:MDS1(gene name synonym)|uniprotkb:Myelodysplasia syndrome 1 protein(gene name synonym)|uniprotkb:Myelodysplasia syndrome-associated protein 1(gene name synonym)|uniprotkb:MDS1 and EVI1 complex locus protein(gene name synonym)|uniprotkb:PRDM3(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702490|imex:IM-22632-807	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_001098547.3|refseq:NP_001098548.2|refseq:NP_001157471.1|refseq:NP_001157472.1|refseq:NP_001192123.1|refseq:NP_004982.2|refseq:NP_005232.2|ensembl:ENSG00000085276(gene)|ensembl:ENST00000494292(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0071425"(hematopoietic stem cell proliferation)|interpro:IPR001214(SET)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR044411|mint:Q03112|rcsb pdb:6BW3|reactome:R-HSA-3214841|reactome:R-HSA-8943724|interpro:IPR036236|refseq:XP_016861363.1|refseq:XP_016861364.1|refseq:XP_016861365.1|refseq:XP_005247278.1|refseq:XP_005247280.1|refseq:XP_005247272.1|dip:DIP-38639N|refseq:XP_005247276.1|refseq:XP_005247277.1|entrezgene/locuslink:2122(identity)|refseq:XM_006713537.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2018/04/06	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:MAlEIuVZS4+BNoy50jejv2O30WA9606	intact-crc:1821AA6D435523D6|rigid:fFxY5bzv33y+5MXuz0J+C5aR1yo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16333	uniprotkb:Q92569	intact:EBI-389883|uniprotkb:B7Z751|ensembl:ENSP00000288986|ensembl:ENSP00000417273|intact:EBI-3448658|uniprotkb:D3DNE3	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:nck1_human(display_long)|uniprotkb:NCK1(gene name)|psi-mi:NCK1(display_short)|uniprotkb:NCK(gene name synonym)|uniprotkb:NCK adaptor protein 1(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-alpha(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702479|imex:IM-22632-806	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278928.1|ensembl:ENSG00000158092(gene)|ensembl:ENST00000288986(transcript)|ensembl:ENST00000481752(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007172"(signal complex assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|refseq:NP_001177725.1|refseq:NP_006144.1|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|mint:P16333|rcsb pdb:2CI8|rcsb pdb:2CI9|rcsb pdb:2CUB|rcsb pdb:2JS0|rcsb pdb:2JS2|rcsb pdb:2JW4|rcsb pdb:5QU1|rcsb pdb:5QU2|rcsb pdb:5QU3|rcsb pdb:5QU4|rcsb pdb:5QU5|rcsb pdb:5QU6|rcsb pdb:5QU7|rcsb pdb:5QU8|rcsb pdb:5QUA|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-373753|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9664422|reactome:R-HSA-983695|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|dip:DIP-639N|entrezgene/locuslink:4690(identity)|refseq:NM_006153.5(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), SYK (P43405)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:UzgLYRQQ9VjN7eKkgn76At/7cSA9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:A5C1770A088D608C|rigid:Ym2EM8XfUd8Kpj61wy17hzRbBaQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N2H9	uniprotkb:Q92569	intact:EBI-448457|uniprotkb:Q8N3E1|uniprotkb:Q8N9Q6|uniprotkb:Q8TAW7|uniprotkb:Q8TED5|ensembl:ENSP00000322532	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:peli3_human(display_long)|uniprotkb:PELI3(gene name)|psi-mi:PELI3(display_short)|uniprotkb:RING-type E3 ubiquitin transferase pellino homolog 3(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702501|imex:IM-22632-808	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001091980.1|refseq:NP_001230064.1|refseq:NP_659502.2|refseq:NP_001230065.1|refseq:XP_011543186.1|refseq:XP_016872954.1|dip:DIP-31770N|ensembl:ENSG00000174516(gene)|ensembl:ENST00000320740(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008592"(regulation of Toll signaling pathway)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR006800(Pellino)|mint:Q8N2H9|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-975144|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|entrezgene/locuslink:246330(identity)|refseq:NM_145065.2(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:rj8IvjYfW2mL1sK2/f6O2cinMNo9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:1E47CBE673BC16F2|rigid:a80TH7qq+xv4XUWoZnk/icRsUqQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NA54	uniprotkb:Q92569	intact:EBI-10220600|ensembl:ENSP00000324882|ensembl:ENSP00000417769|uniprotkb:Q49AL6|uniprotkb:A4D0X0|uniprotkb:Q8N9Y2|uniprotkb:Q5BJD9|uniprotkb:Q4G189|uniprotkb:Q6NUH6	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:iqub_human(display_long)|uniprotkb:IQUB(gene name)|psi-mi:IQUB(display_short)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702512|imex:IM-22632-809	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164675(gene)|ensembl:ENST00000324698(transcript)|ensembl:ENST00000466202(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0060271"(cilium assembly)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR037695|rcsb pdb:2DAF|refseq:XP_016867260.1|refseq:NP_001269784.1|refseq:NP_849149.3|refseq:XP_005250218.1|refseq:NP_001308222.1|refseq:XP_011514135.1|refseq:XP_011514136.1|refseq:XM_005250162.2(identity)|entrezgene/locuslink:154865(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:DyNYrJx7MGhPYi/ba2kD4o+O/J49606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:10F4C034FC170E85|rigid:FEJ7LzZPUJDTPCXUBazzXrkL0Pc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q9Y5E4	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-1045222|uniprotkb:Q9UFU9|uniprotkb:Q549F4|ensembl:ENSP00000231134	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:pcdb5_human(display_long)|uniprotkb:PCDHB5(gene name)|psi-mi:PCDHB5(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702523|imex:IM-22632-810	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	ensembl:ENSG00000113209(gene)|ensembl:ENST00000231134(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0045202"(synapse)|interpro:IPR002126(Cadherin)|interpro:IPR013164(Cadherin, N-terminal)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR030730|interpro:IPR032455|refseq:NP_056484.2|refseq:NM_015669.3(identity)|entrezgene/locuslink:26167(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FYN (P06241), JAK2 (O60674), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:JHnksp8PK/4ubg/jnTZBT/uiLlk9606	intact-crc:6DD7A9F672EE4C97|rigid:CUSKG25kjdzLy34zqVo1QfI1gao	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q92569	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702534|imex:IM-22632-811	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:D2B544B2EE42BB65|rigid:gPgLN8riqP1Ovr8YBlWjqa/T7Vs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:P46108	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702545|imex:IM-22632-812	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:B5CC208C67C35985|rigid:rRiTpdQzDV8gPyvEI+eLKxP+Ohk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q92569	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702556|imex:IM-22632-813	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:9E41F0D0776D4C6D|rigid:8u9YYq6pOBuCfFBRda37Yfi2LP0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:O75461	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-749694|uniprotkb:O60544|uniprotkb:Q53QY9|uniprotkb:Q7Z2H6|uniprotkb:A8K2Z8|uniprotkb:G5E936|uniprotkb:Q6Q9Z6|ensembl:ENSP00000370936	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:e2f6_human(display_long)|uniprotkb:E2F6(gene name)|psi-mi:E2F6(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702567|imex:IM-22632-814	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_001265204.1|refseq:NP_001265205.1|refseq:NP_001265206.1|refseq:NP_001265207.1|refseq:NP_937987.2|dip:DIP-41699N|ensembl:ENSG00000169016(gene)|ensembl:ENST00000381525(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR015635(Transcription Factor E2F6)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:O75461|reactome:R-HSA-69205|reactome:R-HSA-8953750|interpro:IPR032198|refseq:NM_198256.3(identity)|entrezgene/locuslink:1876(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:HZpQSfeASNNMLz4NCYOp6T0yXTk9606	intact-crc:F0470794D05CCB7E|rigid:ePAXXvE202j4UX4xvh55+D4sfxM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6GQQ9	uniprotkb:Q92569	intact:EBI-527784|uniprotkb:Q8WWA7|uniprotkb:Q9NQ53|uniprotkb:Q9UFF4|uniprotkb:Q5SZ60|ensembl:ENSP00000462729|uniprotkb:D3DUZ8|uniprotkb:B7Z643	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:otu7b_human(display_long)|uniprotkb:Zinc finger protein Cezanne(gene name synonym)|uniprotkb:Zinc finger A20 domain-containing protein 1(gene name synonym)|uniprotkb:Cellular zinc finger anti-NF-kappa-B protein(gene name synonym)|uniprotkb:OTUD7B(gene name)|psi-mi:OTUD7B(display_short)|uniprotkb:ZA20D1(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702578|imex:IM-22632-815	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-33805N|ensembl:ENSG00000264522(gene)|ensembl:ENST00000581312(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003323(Ovarian tumour, otubain)|rcsb pdb:5LRU|rcsb pdb:5LRV|rcsb pdb:5LRW|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689896|ensembl:ENSP00000462729|refseq:NP_064590.2|refseq:NM_020205.3(identity)|entrezgene/locuslink:56957(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:JZKj6CpuUOQ3aqvmg3YC9OnivGM9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:AFDA14EFB43A9457|rigid:n61cEsKi8pHx3kMuj8eQZIsQ3vw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q9NPB6-2	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-10693102|ensembl:ENSP00000392388	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:q9npb6-2(display_long)|uniprotkb:PARD6A(gene name)|psi-mi:PARD6A(display_short)|uniprotkb:PAR6A(gene name synonym)|uniprotkb:PAR6C(gene name synonym)|uniprotkb:Tax interaction protein 40(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702589|imex:IM-22632-816	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	intact:EBI-81876(isoform-parent)|ensembl:ENSG00000102981(gene)|ensembl:ENST00000458121(transcript)|uniprotkb:Q9NPB6-2(isoform-parent)|refseq:NM_001037281.1(identity)|entrezgene/locuslink:50855(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:hLX1kt+/BGPnr4HvpWndVysxrTU9606	intact-crc:383A8403A1BA6235|rigid:K1GhwAs/nCfrSXIkvVeP3DngJUo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q92625	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-1048612|uniprotkb:Q5JYI9|uniprotkb:Q5SYR2|uniprotkb:Q86WQ7|uniprotkb:A2RUC1|ensembl:ENSP00000353518|uniprotkb:B4DQW8	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:ans1a_human(display_long)|uniprotkb:Odin(gene name synonym)|uniprotkb:ANKS1A(gene name)|psi-mi:ANKS1A(display_short)|uniprotkb:ANKS1(gene name synonym)|uniprotkb:KIAA0229(gene name synonym)|uniprotkb:ODIN(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702611|imex:IM-22632-818	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:NP_056060.2|ensembl:ENSG00000064999(gene)|ensembl:ENST00000360359(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0016322"(neuron remodeling)|go:"GO:0043005"(neuron projection)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:1901187"(regulation of ephrin receptor signaling pathway)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR033637|interpro:IPR036770|interpro:IPR041880|interpro:IPR041882|mint:Q92625|rcsb pdb:2LMR|rcsb pdb:2MYQ|rcsb pdb:6F7O|refseq:NM_015245.2(identity)|entrezgene/locuslink:23294(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:VTw7RU5nIxHSxvQdBUT/YFlQzU89606	intact-crc:8CC51EBFB23D2DE7|rigid:Vw8dTQv+is89fXY1Xe5d2IvKoDk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53672	uniprotkb:Q92569	intact:EBI-750444|uniprotkb:Q9Y562|uniprotkb:Q4ZFX0|ensembl:ENSP00000295728|ensembl:ENSP00000375946	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:crba2_human(display_long)|uniprotkb:Beta-A2 crystallin(gene name synonym)|uniprotkb:CRYBA2(gene name)|psi-mi:CRYBA2(display_short)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702600|imex:IM-22632-817	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476434.1|refseq:NP_476435.1|ensembl:ENSG00000163499(gene)|ensembl:ENST00000295728(transcript)|ensembl:ENST00000392096(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|mint:P53672|entrezgene/locuslink:1412(identity)|refseq:NM_057094.1(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/WkdaQ4LTxa9mpIiOwVuhd375mE9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:637AC1F280671CA3|rigid:QiwDJtJbxb1JQtZfon0yBo8GD+g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96JZ2	uniprotkb:Q92569	intact:EBI-3919324|intact:EBI-28973686|ensembl:ENSP00000482604|ensembl:ENSP00000483354|uniprotkb:B5ME72|uniprotkb:Q6ZNG7	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:hsh2d_human(display_long)|uniprotkb:HSH2D(gene name)|psi-mi:HSH2D(display_short)|uniprotkb:ALX(gene name synonym)|uniprotkb:Adaptor in lymphocytes of unknown function X(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702622|imex:IM-22632-819	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000483354|ensembl:ENSP00000482604|ensembl:ENSG00000196684(gene)|ensembl:ENST00000613986(transcript)|ensembl:ENST00000616645(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR035047|interpro:IPR036860|rcsb pdb:2CS0|go:"GO:0005737"(cytoplasm)|refseq:NP_116244.1|refseq:NP_001278203.1|refseq:NM_032855.3(identity)|entrezgene/locuslink:84941(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Y01YjkfU/oOtbz2TdQcnm+lBWhs9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:7E0FDBE7F8F6FA3C|rigid:2rTPfMRnBAveVHi2e5bBOVy8Xcg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:P42684-3	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-10693977|ensembl:ENSP00000423578	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:p42684-3(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym)|uniprotkb:1ALCTL(isoform synonym)|uniprotkb:IC(isoform synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702633|imex:IM-22632-820	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	ensembl:ENSG00000143322(gene)|ensembl:ENST00000512653(transcript)|intact:EBI-1102694(isoform-parent)|uniprotkb:P42684-3(isoform-parent)|refseq:NM_005158.4(identity)|entrezgene/locuslink:27(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:gLzqA1k71ptItAHexZD/6P1Ilos9606	intact-crc:6F0E86180F51DD83|rigid:6SBxBOH38zYawcuVRWVpiMAS7y8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43559	uniprotkb:Q92569	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702655|imex:IM-22632-822	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:5545C0C5227DD7AE|rigid:fscct1zSG/oVWU61u/B9+IW1+EA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q66PJ3-4	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-5280499	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:q66pj3-4(display_long)|uniprotkb:Splicing factor SRrp37(gene name synonym)|uniprotkb:ARL6IP4(gene name)|psi-mi:ARL6IP4(display_short)|uniprotkb:HSP-975(gene name synonym)|uniprotkb:HSVI-binding protein(gene name synonym)|uniprotkb:SR-15(gene name synonym)|uniprotkb:SRp25(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702644|imex:IM-22632-821	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	intact:EBI-2683099(isoform-parent)|uniprotkb:Q66PJ3-4(isoform-parent)|entrezgene/locuslink:51329(identity)|refseq:NM_001002252.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), LYN (P07948), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:XZT/eX9V6PNVyIyUg7RvZpH0Ydg9606	intact-crc:BD4CC66D9B0D1E35|rigid:mCY4QnCt4aqMHLGj3Yv+CkaHsT0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q06187	uniprotkb:Q92569	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702677|imex:IM-22632-824	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N|refseq:NM_000061.2(identity)|entrezgene/locuslink:695(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:A87410C45F1A28F3|rigid:pS3OvFBl0D1pTko7GV5we+dBtJM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q8WZ19	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-742916|ensembl:ENSP00000311202|ensembl:ENSP00000455785|uniprotkb:Q96P93|uniprotkb:Q96SA1|uniprotkb:A8K0R5	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:bacd1_human(display_long)|uniprotkb:Polymerase delta-interacting protein 1(gene name synonym)|uniprotkb:TNFAIP1-like protein(gene name synonym)|uniprotkb:KCTD13(gene name)|psi-mi:KCTD13(display_short)|uniprotkb:PDIP1(gene name synonym)|uniprotkb:POLDIP1(gene name synonym)|uniprotkb:FKSG86(orf name)|uniprotkb:PP6832(orf name)|uniprotkb:BACURD1(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein KCTD13(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702688|imex:IM-22632-825	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_849194.1|ensembl:ENSG00000174943(gene)|ensembl:ENST00000308768(transcript)|ensembl:ENST00000568000(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q8WZ19|rcsb pdb:4UIJ|reactome:R-HSA-9696264|reactome:R-HSA-9696270|entrezgene/locuslink:253980(identity)|refseq:NM_178863.4(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:hAH5yJEoda0H1anmnSXWHO0o1ZM9606	intact-crc:BFEA0FC8B6D33B18|rigid:vKatw7RiTQWBNg5qsWiVvkS31Ps	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:P08631-2	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-9834454|ensembl:ENSP00000429848|ensembl:ENSP00000486627	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:p08631-2(display_long)|uniprotkb:p59-HCK(isoform synonym)|uniprotkb:p59Hck(isoform synonym)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702666|imex:IM-22632-823	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	uniprotkb:P08631-2(isoform-parent)|intact:EBI-346340(isoform-parent)|ensembl:ENSG00000101336(gene)|ensembl:ENST00000520553(transcript)|ensembl:ENST00000629881(transcript)|entrezgene/locuslink:3055(identity)|refseq:NM_001172129.1(identity)	-	-	isoform-comment:Initiator Met-1 is removed. Contains a N-myristoyl glycine at position 2. Contains a S-palmitoyl cysteine at position 3.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:qSgfntp+jqdyi7qsc7u7UA7ylO09606	intact-crc:B302A7D6BD3D733F|rigid:qfJOe/FsOciLbpYBqVn5AZMH/88	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q8WZ19	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-742916|ensembl:ENSP00000311202|ensembl:ENSP00000455785|uniprotkb:Q96P93|uniprotkb:Q96SA1|uniprotkb:A8K0R5	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:bacd1_human(display_long)|uniprotkb:Polymerase delta-interacting protein 1(gene name synonym)|uniprotkb:TNFAIP1-like protein(gene name synonym)|uniprotkb:KCTD13(gene name)|psi-mi:KCTD13(display_short)|uniprotkb:PDIP1(gene name synonym)|uniprotkb:POLDIP1(gene name synonym)|uniprotkb:FKSG86(orf name)|uniprotkb:PP6832(orf name)|uniprotkb:BACURD1(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein KCTD13(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702699|imex:IM-22632-826	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_849194.1|ensembl:ENSG00000174943(gene)|ensembl:ENST00000308768(transcript)|ensembl:ENST00000568000(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q8WZ19|rcsb pdb:4UIJ|reactome:R-HSA-9696264|reactome:R-HSA-9696270|entrezgene/locuslink:253980(identity)|refseq:NM_178863.4(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:hAH5yJEoda0H1anmnSXWHO0o1ZM9606	intact-crc:A3487C2F142E2FB1|rigid:1Y1/pIVypIqqkBDyKU8H6ZmXIU8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WY64	uniprotkb:Q9UN19	intact:EBI-6952711|ensembl:ENSP00000349298|uniprotkb:Q9BU73|uniprotkb:Q9UHE7|intact:MINT-8162265|uniprotkb:Q5TIA4|uniprotkb:Q9NRL9|intact:MINT-268789	intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602	psi-mi:mylip_human(display_long)|uniprotkb:MYLIP(gene name)|psi-mi:MYLIP(display_short)|uniprotkb:BZF1(gene name synonym)|uniprotkb:IDOL(gene name synonym)|uniprotkb:Inducible degrader of the LDL-receptor(gene name synonym)|uniprotkb:Myosin regulatory light chain interacting protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MYLIP(gene name synonym)|uniprotkb:BM-023(orf name)|uniprotkb:PP5242(orf name)	psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702710|imex:IM-22632-827	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000007944(gene)|ensembl:ENST00000356840(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031648"(protein destabilization)|go:"GO:0032803"(regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0005886"(plasma membrane)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041790|mint:Q8WY64|rcsb pdb:2YHN|rcsb pdb:2YHO|rcsb pdb:6QLY|rcsb pdb:6QLZ|reactome:R-HSA-8866427|reactome:R-HSA-9031525|reactome:R-HSA-983168|refseq:NP_037394.2|entrezgene/locuslink:29116(identity)|refseq:NM_013262.3(identity)	refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695|entrezgene/locuslink:27071(identity)|refseq:NM_014395.2(identity)	-	comment:mint|comment:homomint|function:"E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC). Stable or transient overexpression of MIR induces proteasomal degradation of MRLC inhibiting neurite outgrowth in presence of NGF. MIR counteracts the stabilization of MRLC by MIR-interacting saposin-like protein (MSAP/TMEM4) and reduces MSAP-stimulated neurite outgrowth"	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:kkDkk49icU/zPJmjNiiaQ5GIx+w9606	rogid:YYI49xKbndaB1MfL/QEovp2BF009606	intact-crc:3EAC722FE5CF3B78|rigid:6gmMIgUR4GWg/Ys0mAWMOEQS9Fg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WY64	uniprotkb:P46108-2	intact:EBI-6952711|ensembl:ENSP00000349298|uniprotkb:Q9BU73|uniprotkb:Q9UHE7|intact:MINT-8162265|uniprotkb:Q5TIA4|uniprotkb:Q9NRL9|intact:MINT-268789	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:mylip_human(display_long)|uniprotkb:MYLIP(gene name)|psi-mi:MYLIP(display_short)|uniprotkb:BZF1(gene name synonym)|uniprotkb:IDOL(gene name synonym)|uniprotkb:Inducible degrader of the LDL-receptor(gene name synonym)|uniprotkb:Myosin regulatory light chain interacting protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MYLIP(gene name synonym)|uniprotkb:BM-023(orf name)|uniprotkb:PP5242(orf name)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702721|imex:IM-22632-828	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000007944(gene)|ensembl:ENST00000356840(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031648"(protein destabilization)|go:"GO:0032803"(regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0005886"(plasma membrane)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041790|mint:Q8WY64|rcsb pdb:2YHN|rcsb pdb:2YHO|rcsb pdb:6QLY|rcsb pdb:6QLZ|reactome:R-HSA-8866427|reactome:R-HSA-9031525|reactome:R-HSA-983168|refseq:NP_037394.2|entrezgene/locuslink:29116(identity)|refseq:NM_013262.3(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	comment:mint|comment:homomint|function:"E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC). Stable or transient overexpression of MIR induces proteasomal degradation of MRLC inhibiting neurite outgrowth in presence of NGF. MIR counteracts the stabilization of MRLC by MIR-interacting saposin-like protein (MSAP/TMEM4) and reduces MSAP-stimulated neurite outgrowth"	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:kkDkk49icU/zPJmjNiiaQ5GIx+w9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:898F5A7478CF8902|rigid:1VpTy/d88G8B6xAHSIh6TJJEBHs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WXH5	uniprotkb:Q8N3R9	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	intact:EBI-2513978|ensembl:ENSP00000261681|ensembl:ENSP00000503321|ensembl:ENSP00000503322|ensembl:ENSP00000503517|ensembl:ENSP00000503713|uniprotkb:Q86T98|uniprotkb:Q8N7I5|uniprotkb:Q7Z631|uniprotkb:Q9H9Q0|uniprotkb:A1L380	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:pals1_human(display_long)|uniprotkb:PALS1(gene name)|psi-mi:PALS1(display_short)|uniprotkb:MAGUK p55 subfamily member 5(gene name synonym)|uniprotkb:MPP5(gene name synonym)|uniprotkb:Membrane protein, palmitoylated 5(gene name synonym)|uniprotkb:Protein associated with Lin-7 1(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702732|imex:IM-22632-829	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0010467"(gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032288"(myelin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035750"(protein localization to myelin sheath abaxonal region)|go:"GO:0043204"(perikaryon)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR015145(L27-N)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035601|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q8N3R9|rcsb pdb:1Y76|rcsb pdb:3UIT|rcsb pdb:4UU5|rcsb pdb:4UU6|rcsb pdb:4WSI|rcsb pdb:7M4R|rcsb pdb:7NTJ|rcsb pdb:7NTK|reactome:R-HSA-420029|ensembl:ENSG00000072415(gene)|ensembl:ENST00000261681(transcript)|ensembl:ENST00000676464(transcript)|ensembl:ENST00000677382(transcript)|ensembl:ENST00000677835(transcript)|ensembl:ENST00000678380(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|refseq:XP_011535388.1|refseq:XP_011535389.1|refseq:NP_071919.2|refseq:NP_001243479.1|refseq:XP_005268060.1|entrezgene/locuslink:64398(identity)|refseq:NM_022474.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FES (P07332), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	rogid:VpQVKlVcuBSs8mztUd9iHqkIXDM9606	intact-crc:5BF589A8D8D7B032|rigid:pNjH73foh7G3nEflveG9b9d+keE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-10696539	uniprotkb:Q8WXH5	-	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	psi-mi:ppapdc2(display_short)|psi-mi:EBI-10696539(display_long)	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702743|imex:IM-22632-830	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NM_203453.3(identity)|entrezgene/locuslink:403313(identity)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	-	no-uniprot-update:	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:+Z2B+dJTsflTkv7ROiuer/ulCws9606	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	intact-crc:C4D1B58B7E4E3955|rigid:iKVu5Lf6gFqeKaDHyiePniRxH3g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WXH5	uniprotkb:Q96R05	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	intact:EBI-2856326|uniprotkb:B2R517|uniprotkb:Q5SWJ4|ensembl:ENSP00000294435	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:ret7_human(display_long)|uniprotkb:RBP7(gene name)|psi-mi:RBP7(display_short)|uniprotkb:Cellular retinoic acid-binding protein 4(gene name synonym)|uniprotkb:Cellular retinoic acid-binding protein IV(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702754|imex:IM-22632-831	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	refseq:NP_443192.1|interpro:IPR031259|rcsb pdb:1LPJ|rcsb pdb:6AT8|rcsb pdb:6E6K|ensembl:ENSG00000162444(gene)|ensembl:ENST00000294435(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016918"(retinal binding)|go:"GO:0019841"(retinol binding)|interpro:IPR000463(Cytosolic fatty-acid binding)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|entrezgene/locuslink:116362(identity)|refseq:NM_052960.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	rogid:75axWxV5mnxExd1avjdlOUK4o2E9606	intact-crc:EFB552BE126BFFC2|rigid:xx2daNyRU+x+ug9JMXiLcab3ajI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXM7	uniprotkb:Q8WXH5	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702765|imex:IM-22632-832	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N|entrezgene/locuslink:65018(identity)|refseq:NM_032409.2(identity)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	intact-crc:A7A1E2F9F258881C|rigid:jeSxNnYq9fpGbm0LS1OKSzjQLqs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BYZ2	uniprotkb:Q8WXH5	intact:EBI-1108377|uniprotkb:Q6DUY4|uniprotkb:Q96LI2|ensembl:ENSP00000302393	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	psi-mi:ldh6b_human(display_long)|uniprotkb:LDHAL6B(gene name)|psi-mi:LDHAL6B(display_short)|uniprotkb:LDHAL6(gene name synonym)|uniprotkb:LDHL(gene name synonym)	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702776|imex:IM-22632-833	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000171989(gene)|ensembl:ENST00000307144(transcript)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:Q9BYZ2|reactome:R-HSA-70268|refseq:NP_149972.1|entrezgene/locuslink:92483(identity)|refseq:NM_033195.2(identity)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:VktHnjwxkeayt64SWFxLAq4YlLQ9606	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	intact-crc:35DBAF0154939DC0|rigid:v2Wz0+mv8y9XwbrCjqno37FR8Yo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q8WXH5	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702798|imex:IM-22632-835	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	intact-crc:847C216F1E86ABBB|rigid:7zpzclblMW0lSAxlChMrga4jppg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75829-2	uniprotkb:Q8WXH5	intact:EBI-10696063|ensembl:ENSP00000388576	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	psi-mi:o75829-2(display_long)|uniprotkb:MYETS1(gene name synonym)|uniprotkb:CNMD(gene name)|psi-mi:CNMD(display_short)|uniprotkb:CHMI(gene name synonym)|uniprotkb:Chondromodulin(gene name synonym)|uniprotkb:LECT1(gene name synonym)	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702787|imex:IM-22632-834	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1220187(isoform-parent)|uniprotkb:O75829-2(isoform-parent)|ensembl:ENSG00000136110(gene)|ensembl:ENST00000448904(transcript)|refseq:NM_001011705.1(identity)|entrezgene/locuslink:11061(identity)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	-	isoform-comment:No experimental confirmation available.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:PFYeXYbyIK2gv+GHHQBqfAR2Erg9606	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	intact-crc:51BBFAE8856E3C82|rigid:fV8WW25CLtHsKimCHDPmYvly17k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q8WXH5	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702809|imex:IM-22632-836	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	intact-crc:A50A7668C1951559|rigid:HSH4BIaK53MwkzzXpWiE6XD6pw8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BSQ5	uniprotkb:Q8WVJ9	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	intact:EBI-1797313|uniprotkb:Q3SYL6|ensembl:ENSP00000405176|ensembl:ENSP00000482581|ensembl:ENSP00000500440|ensembl:ENSP00000500609	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:twst2_human(display_long)|uniprotkb:Dermis-expressed protein 1(gene name synonym)|uniprotkb:TWIST2(gene name)|psi-mi:TWIST2(display_short)|uniprotkb:DERMO1(gene name synonym)|uniprotkb:BHLHA39(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 39(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702820|imex:IM-22632-837	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N|refseq:NM_031443.3(identity)|entrezgene/locuslink:83605(identity)	refseq:NP_001258822.1|refseq:NP_476527.1|ensembl:ENSG00000233608(gene)|ensembl:ENSG00000288335(gene)|ensembl:ENST00000448943(transcript)|ensembl:ENST00000612363(transcript)|ensembl:ENST00000671947(transcript)|ensembl:ENST00000673387(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032502"(developmental process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015789(Twist)|interpro:IPR036638|reactome:R-HSA-8878166|entrezgene/locuslink:117581(identity)|refseq:NM_057179.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813), FRK (P42685), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	rogid:IYIpMXYdrqllQqS+Ftz+P0xtk789606	intact-crc:4063B86D8F734445|rigid:q28n3k04QLjqaBiKQ3h7blFJNmI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16591	uniprotkb:Q8WVF5	intact:EBI-1380661|uniprotkb:B4DSQ2|uniprotkb:B2RCR4|uniprotkb:H2FLB8|ensembl:ENSP00000281092	intact:EBI-741463|ensembl:ENSP00000368402|uniprotkb:Q5W0P9	psi-mi:fer_human(display_long)|uniprotkb:Feline encephalitis virus-related kinase FER(gene name synonym)|uniprotkb:Fujinami poultry sarcoma/Feline sarcoma-related protein Fer(gene name synonym)|uniprotkb:FER(gene name)|psi-mi:FER(display_short)|uniprotkb:TYK3(gene name synonym)|uniprotkb:Proto-oncogene c-Fer(gene name synonym)|uniprotkb:Tyrosine kinase 3(gene name synonym)|uniprotkb:p94-Fer(gene name synonym)	psi-mi:kctd4_human(display_long)|uniprotkb:KCTD4(gene name)|psi-mi:KCTD4(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702831|imex:IM-22632-838	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005237.2|refseq:XP_016864719.1|refseq:XP_016864720.1|refseq:NP_001294957.1|refseq:NP_001294960.1|refseq:NP_001294967.1|refseq:XP_011541573.1|ensembl:ENSG00000151422(gene)|ensembl:ENST00000281092(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033007"(negative regulation of mast cell activation involved in immune response)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0036119"(response to platelet-derived growth factor)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038109"(Kit signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050904"(diapedesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR028539|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|interpro:IPR037452|mint:P16591|rcsb pdb:2KK6|rcsb pdb:6KC4|reactome:R-HSA-1433557|entrezgene/locuslink:2241(identity)|refseq:NM_005246.2(identity)	ensembl:ENSG00000180332(gene)|ensembl:ENST00000379108(transcript)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|refseq:NP_940686.2|entrezgene/locuslink:386618(identity)|refseq:NM_198404.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:De5RYVRGihPHGxaflmxR8W9jC8M9606	rogid:03cd1lqmT8fReXzYqjrKSWUdqY89606	intact-crc:18AACA39BCEC9DEB|rigid:bQbEl3I+vF/JbNcxPk2xKW10vC0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WUD1	uniprotkb:P46108-2	intact:EBI-5542466|ensembl:ENSP00000380869|uniprotkb:B2RD03|uniprotkb:D3DS24|uniprotkb:Q6NZ33	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:rab2b_human(display_long)|uniprotkb:RAB2B(gene name)|psi-mi:RAB2B(display_short)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702842|imex:IM-22632-839	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156852.1|ensembl:ENST00000397762(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2A5J|reactome:R-HSA-8873719|ensembl:ENSG00000129472(gene)|refseq:NP_116235.2|refseq:XP_016877200.1|refseq:NM_001163380.1(identity)|entrezgene/locuslink:84932(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:wj76bPe9YR4JnqPm07VAqCa+CqY9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:C90A29AD447D394F|rigid:bSNMJvYMxECftS1bMMca7CB7zMM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TEW6	uniprotkb:Q9BSQ5	intact:EBI-6918542|ensembl:ENSP00000344277|ensembl:ENSP00000455128|uniprotkb:O75209|uniprotkb:Q9BTP2|uniprotkb:Q9NVV3	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	psi-mi:dok4_human(display_long)|uniprotkb:DOK4(gene name)|psi-mi:DOK4(display_short)|uniprotkb:Downstream of tyrosine kinase 4(gene name synonym)|uniprotkb:Insulin receptor substrate 5(gene name synonym)	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702864|imex:IM-22632-841	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000125170(gene)|ensembl:ENST00000340099(transcript)|ensembl:ENST00000569548(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0043410"(positive regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_060580.2|refseq:XP_005256100.1|entrezgene/locuslink:55715(identity)|refseq:NM_018110.3(identity)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N|refseq:NM_031443.3(identity)|entrezgene/locuslink:83605(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:Xc4aPsHtdQKj02Q5cqqgw29pSS09606	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	intact-crc:17FDE94C132247D4|rigid:stzbqPSyL/LLqKnKP/O4C2M5pRA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7L591-3	uniprotkb:Q8TEW6	intact:EBI-10694655|ensembl:ENSP00000325174	intact:EBI-6918542|ensembl:ENSP00000344277|ensembl:ENSP00000455128|uniprotkb:O75209|uniprotkb:Q9BTP2|uniprotkb:Q9NVV3	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:dok4_human(display_long)|uniprotkb:DOK4(gene name)|psi-mi:DOK4(display_short)|uniprotkb:Downstream of tyrosine kinase 4(gene name synonym)|uniprotkb:Insulin receptor substrate 5(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702853|imex:IM-22632-840	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	ensembl:ENSG00000125170(gene)|ensembl:ENST00000340099(transcript)|ensembl:ENST00000569548(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0043410"(positive regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_060580.2|refseq:XP_005256100.1|entrezgene/locuslink:55715(identity)|refseq:NM_018110.3(identity)	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), SYK (P43405), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	rogid:Xc4aPsHtdQKj02Q5cqqgw29pSS09606	intact-crc:61B2EC031D15B15C|rigid:VUiYbDs/JrSzUQfDOdHbLd3vMyw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q8TD91-2	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-10694180|ensembl:ENSP00000386566|ensembl:ENSP00000440444	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:q8td91-2(display_long)|uniprotkb:MAGEC3(gene name)|psi-mi:MAGEC3(display_short)|uniprotkb:Cancer/testis antigen 7.2(gene name synonym)|uniprotkb:HCA2(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 2(gene name synonym)|uniprotkb:MAGE-C3 antigen(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702886|imex:IM-22632-843	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	intact:EBI-10757207(isoform-parent)|ensembl:ENSG00000165509(gene)|ensembl:ENST00000409007(transcript)|ensembl:ENST00000544766(transcript)|uniprotkb:Q8TD91-2(isoform-parent)|entrezgene/locuslink:139081(identity)|refseq:NM_177456.2(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	isoform-comment:No experimental confirmation available.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:5MPHZJq+bFnzYfBFgRSoY+GYroQ9606	intact-crc:6DCAEF4DC83E1346|rigid:vovTUDhxYQrrH0ANZPXcgL89PaI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q8TE12	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-10692065|uniprotkb:Q5VWG4|uniprotkb:Q0VDB5|uniprotkb:B3KXP6|uniprotkb:Q8TE11|ensembl:ENSP00000294816|ensembl:ENSP00000340226|ensembl:ENSP00000356868	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:lmx1a_human(display_long)|uniprotkb:LMX1A(gene name)|psi-mi:LMX1A(display_short)|uniprotkb:LIM/homeobox protein 1.1(gene name synonym)|uniprotkb:LIM/homeobox protein LMX1A(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702875|imex:IM-22632-842	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	refseq:NP_001167540.1|refseq:NP_796372.1|go:"GO:0046872"(metal ion binding)|go:"GO:0050808"(synapse organization)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR042688|ensembl:ENSG00000162761(gene)|ensembl:ENST00000294816(transcript)|ensembl:ENST00000342310(transcript)|ensembl:ENST00000367893(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021549"(cerebellum development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0042048"(olfactory behavior)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|entrezgene/locuslink:4009(identity)|refseq:XM_006711319.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FER (P16591), FGR (P09769), FYN (P06241), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:1Lm6PRjM5McmrHXC9GVW9zlWvDg9606	intact-crc:3A4936545BADB9A9|rigid:f3Z6f/LfZJFnQXE9fhnRB2QXqRk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TD91-2	uniprotkb:Q9UKG1	intact:EBI-10694180|ensembl:ENSP00000386566|ensembl:ENSP00000440444	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:q8td91-2(display_long)|uniprotkb:MAGEC3(gene name)|psi-mi:MAGEC3(display_short)|uniprotkb:Cancer/testis antigen 7.2(gene name synonym)|uniprotkb:HCA2(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 2(gene name synonym)|uniprotkb:MAGE-C3 antigen(gene name synonym)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702897|imex:IM-22632-844	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-10757207(isoform-parent)|ensembl:ENSG00000165509(gene)|ensembl:ENST00000409007(transcript)|ensembl:ENST00000544766(transcript)|uniprotkb:Q8TD91-2(isoform-parent)|entrezgene/locuslink:139081(identity)|refseq:NM_177456.2(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	isoform-comment:No experimental confirmation available.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:5MPHZJq+bFnzYfBFgRSoY+GYroQ9606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:902DB787AEC54A10|rigid:PdcMP2YwvknsqrKoVEOeS/WVMnI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UN19	uniprotkb:Q8TBZ3	intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602	intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0	psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name)	psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702908|imex:IM-22632-845	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695|entrezgene/locuslink:27071(identity)|refseq:NM_014395.2(identity)	ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1|entrezgene/locuslink:91833(identity)|refseq:NM_144574.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FRK (P42685), FYN (P06241), HCK (P08631), LYN (P07948), SRC (P12931), SYK (P43405), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:YYI49xKbndaB1MfL/QEovp2BF009606	rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606	intact-crc:54CA23A97B9C1DDB|rigid:45/uOV2AqDMtDjF1OJMOxrueL00	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52333	uniprotkb:Q8TBB1	intact:EBI-518246|uniprotkb:Q13259|uniprotkb:Q13260|uniprotkb:Q13611|uniprotkb:Q9Y6S2|uniprotkb:Q99699|uniprotkb:Q8N1E8|ensembl:ENSP00000391676|ensembl:ENSP00000432511	intact:EBI-739832|uniprotkb:Q4W5K7|uniprotkb:Q8N4C2|uniprotkb:Q96MJ7|uniprotkb:Q9BY20|ensembl:ENSP00000263925	psi-mi:jak3_human(display_long)|uniprotkb:Janus kinase 3(gene name synonym)|uniprotkb:Leukocyte janus kinase(gene name synonym)|uniprotkb:JAK3(gene name)|psi-mi:JAK3(display_short)	psi-mi:lnx1_human(display_long)|uniprotkb:LNX1(gene name)|psi-mi:LNX1(display_short)|uniprotkb:LNX(gene name synonym)|uniprotkb:Numb-binding protein 1(gene name synonym)|uniprotkb:Ligand of Numb-protein X 1(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 2(gene name synonym)|uniprotkb:PDZRN2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase LNX(gene name synonym)|uniprotkb:UNQ574/PRO1136(orf name)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702919|imex:IM-22632-846	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000206.2|dip:DIP-274N|ensembl:ENST00000458235(transcript)|ensembl:ENST00000527670(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002731"(negative regulation of dendritic cell cytokine production)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071104"(response to interleukin-9)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019749|interpro:IPR020635|interpro:IPR020775|interpro:IPR036860|interpro:IPR041046|rcsb pdb:4HVI|rcsb pdb:4I6Q|rcsb pdb:4QPS|rcsb pdb:4QT1|rcsb pdb:4RIO|rcsb pdb:4V0G|rcsb pdb:4Z16|interpro:IPR041155|interpro:IPR041381|rcsb pdb:1YVJ|rcsb pdb:5LWM|rcsb pdb:5LWN|rcsb pdb:3LXK|rcsb pdb:3LXL|rcsb pdb:3PJC|rcsb pdb:3ZC6|rcsb pdb:3ZEP|rcsb pdb:4HVD|rcsb pdb:4HVG|rcsb pdb:4HVH|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0070232"(regulation of T cell apoptotic process)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0045087"(innate immune response)|go:"GO:0045221"(negative regulation of FasL production)|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|ensembl:ENSG00000105639(gene)|reactome:R-HSA-9020958|reactome:R-HSA-912526|reactome:R-HSA-9679191|rcsb pdb:5TOZ|rcsb pdb:5TTS|rcsb pdb:5TTU|rcsb pdb:5TTV|rcsb pdb:5VO6|rcsb pdb:5W86|rcsb pdb:5WFJ|rcsb pdb:6AAK|rcsb pdb:6DA4|rcsb pdb:6DB3|rcsb pdb:6DB4|rcsb pdb:6DUD|rcsb pdb:6GL9|rcsb pdb:6GLA|rcsb pdb:6GLB|rcsb pdb:6HZV|rcsb pdb:6NY4|rcsb pdb:7APF|rcsb pdb:7APG|rcsb pdb:7C3N|reactome:R-HSA-1266695|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|entrezgene/locuslink:3718(identity)|refseq:NM_000215.3(identity)	refseq:NP_001119800.1|refseq:NP_116011.2|refseq:XP_005265842.1|refseq:XP_016864265.1|ensembl:ENSG00000072201(gene)|ensembl:ENST00000263925(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8TBB1|rcsb pdb:3B76|rcsb pdb:5H7R|rcsb pdb:5H7S|reactome:R-HSA-983168|refseq:NM_001126328.2(identity)|entrezgene/locuslink:84708(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), SYK (P43405)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:cHXRp+Xei7sembAUQyV46ooa+P49606	rogid:tWvePnVxh9yxWl8nQd3KZhCSKKo9606	intact-crc:FBF8377B2DCE989B|rigid:MXKtlvpWA3HqdYqjPhEI/rBkGbQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16333	uniprotkb:Q8TAK6	intact:EBI-389883|uniprotkb:B7Z751|ensembl:ENSP00000288986|ensembl:ENSP00000417273|intact:EBI-3448658|uniprotkb:D3DNE3	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	psi-mi:nck1_human(display_long)|uniprotkb:NCK1(gene name)|psi-mi:NCK1(display_short)|uniprotkb:NCK(gene name synonym)|uniprotkb:NCK adaptor protein 1(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-alpha(gene name synonym)	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702930|imex:IM-22632-847	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278928.1|ensembl:ENSG00000158092(gene)|ensembl:ENST00000288986(transcript)|ensembl:ENST00000481752(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007172"(signal complex assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|refseq:NP_001177725.1|refseq:NP_006144.1|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|mint:P16333|rcsb pdb:2CI8|rcsb pdb:2CI9|rcsb pdb:2CUB|rcsb pdb:2JS0|rcsb pdb:2JS2|rcsb pdb:2JW4|rcsb pdb:5QU1|rcsb pdb:5QU2|rcsb pdb:5QU3|rcsb pdb:5QU4|rcsb pdb:5QU5|rcsb pdb:5QU6|rcsb pdb:5QU7|rcsb pdb:5QU8|rcsb pdb:5QUA|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-373753|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9664422|reactome:R-HSA-983695|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|dip:DIP-639N|entrezgene/locuslink:4690(identity)|refseq:NM_006153.5(identity)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FER (P16591)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:UzgLYRQQ9VjN7eKkgn76At/7cSA9606	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	intact-crc:5A6E86FADB0E9520|rigid:bFUUmPBJxMtwjssIJlawK+OpkGA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49757-3	uniprotkb:Q8TAK6	intact:EBI-10692196|ensembl:ENSP00000352563|ensembl:ENSP00000451117	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	psi-mi:p49757-3(display_long)|uniprotkb:C14orf41(gene name synonym)|uniprotkb:NUMB(gene name)|psi-mi:NUMB(display_short)|uniprotkb:Protein S171(gene name synonym)|uniprotkb:p71(isoform synonym)	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702952|imex:IM-22632-849	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-915016(isoform-parent)|uniprotkb:P49757-3(isoform-parent)|ensembl:ENSG00000133961(gene)|ensembl:ENST00000359560(transcript)|ensembl:ENST00000557597(transcript)|entrezgene/locuslink:8650(identity)|refseq:NM_001005745.1(identity)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:N2YwdjNBMiXeMFYxQrJDxqeNkSA9606	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	intact-crc:418492DA7138B0FA|rigid:KwQRgLy6OwPx9WNd6bS3w7ZTMaA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14451	uniprotkb:Q8TAK6	intact:EBI-970191|ensembl:ENSP00000310771|ensembl:ENSP00000377759|ensembl:ENSP00000377761|uniprotkb:B2RAV1|uniprotkb:B3KNL0|uniprotkb:B3KWP9|uniprotkb:B7WP75|uniprotkb:Q53YD3|uniprotkb:Q9Y220|uniprotkb:Q92568|uniprotkb:Q96DF9|intact:EBI-1257061|uniprotkb:J3KQM4	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	psi-mi:grb7_human(display_long)|uniprotkb:GRB7(gene name)|psi-mi:GRB7(display_short)|uniprotkb:GRB7 adapter protein(gene name synonym)|uniprotkb:Epidermal growth factor receptor GRB-7(gene name synonym)|uniprotkb:B47(gene name synonym)	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702941|imex:IM-22632-848	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141738(gene)|ensembl:ENST00000309156(transcript)|ensembl:ENST00000394209(transcript)|ensembl:ENST00000394211(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042995"(cell projection)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035032|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q14451|rcsb pdb:1MW4|rcsb pdb:1WGR|rcsb pdb:2L4K|rcsb pdb:2QMS|rcsb pdb:3PQZ|rcsb pdb:4WWQ|rcsb pdb:4X6S|rcsb pdb:5D0J|rcsb pdb:5EEL|rcsb pdb:5EEQ|rcsb pdb:5TYI|rcsb pdb:5U06|rcsb pdb:5U1Q|go:"GO:0042802"(identical protein binding)|reactome:R-HSA-1306955|reactome:R-HSA-186763|reactome:R-HSA-210993|reactome:R-HSA-8853659|reactome:R-HSA-9696273|reactome:R-HSA-1433557|refseq:NP_001025173.1|refseq:NP_001229371.1|refseq:NP_001229372.1|refseq:NP_005301.2|refseq:NP_001317136.1|dip:DIP-502N|entrezgene/locuslink:2886(identity)|refseq:NM_001030002.2(identity)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FER (P16591)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:XViWZjk5YwdZFTG3zs2aNdxeFVQ9606	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	intact-crc:E5878F20E79DD8A7|rigid:GebKMHt5elcU4o4cYn+tkSqg0fc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEZ4	uniprotkb:Q8NEU8	intact:EBI-1042997|uniprotkb:Q8NC02|uniprotkb:Q8NDF6|uniprotkb:Q9H9P4|uniprotkb:Q9NR13|uniprotkb:Q9P222|uniprotkb:Q9UDR7|ensembl:ENSP00000262189	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	psi-mi:kmt2c_human(display_long)|uniprotkb:KMT2C(gene name)|psi-mi:KMT2C(display_short)|uniprotkb:HALR(gene name synonym)|uniprotkb:Homologous to ALR protein(gene name synonym)|uniprotkb:KIAA1506(gene name synonym)|uniprotkb:MLL3(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 3(gene name synonym)	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702974|imex:IM-22632-851	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000055609(gene)|ensembl:ENST00000262189(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042393"(histone binding)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0097692"(histone H3-K4 monomethylation)|interpro:IPR000637(HMG-I and HMG-Y, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|go:"GO:0005634"(nucleus)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036910|interpro:IPR037877|interpro:IPR041967|interpro:IPR041968|mint:Q8NEZ4|rcsb pdb:2YSM|rcsb pdb:2YUK|rcsb pdb:3UVL|rcsb pdb:4ERY|rcsb pdb:5F59|rcsb pdb:5F6K|rcsb pdb:6KIW|rcsb pdb:6MLC|reactome:R-HSA-3214841|reactome:R-HSA-5617472|reactome:R-HSA-8936459|refseq:NP_733751.2|ensembl:ENSP00000262189|ensembl:ENST00000682283|ensembl:ENSP00000507485|dip:DIP-48649N|entrezgene/locuslink:58508(identity)|refseq:NM_170606.2(identity)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:NZg8HgfbohMT8EEgAdAgWR1AjSo9606	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	intact-crc:1EBCF32784A0AE0F|rigid:NEqfojpk+JJhzbR44AHnByHeH+8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TAK5	uniprotkb:P46108-2	intact:EBI-8468945|intact:MINT-6778891|uniprotkb:D3DV14|uniprotkb:B1AVJ8|uniprotkb:Q8NAR5|ensembl:ENSP00000357914	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:gabp2_human(display_long)|uniprotkb:GABPB2(gene name)|psi-mi:GABPB2(display_short)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702963|imex:IM-22632-850	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001310837.1|refseq:NP_653219.1|refseq:XP_016855738.1|ensembl:ENSG00000143458(gene)|ensembl:ENST00000368918(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q8TAK5|entrezgene/locuslink:126626(identity)|refseq:NM_144618.2(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	function:"May function as transcription factor capable of interacting with purine rich repeats (GA repeats)"|comment:mint|comment:homomint	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:F1UTCglE16qDpbAHMtdpL/zq8XY9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:ED86FA03AE42D8F5|rigid:TnyDeFCpUaCQeJ4FJm467bvWFwI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEC7	uniprotkb:Q9UN19	intact:EBI-8469616|intact:MINT-6779113|uniprotkb:Q9H8S3|uniprotkb:A8MVD3|uniprotkb:A8K8J0|uniprotkb:H9KV97|ensembl:ENSP00000353695|ensembl:ENSP00000378216|ensembl:ENSP00000422354	intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602	psi-mi:gstcd_human(display_long)|uniprotkb:GSTCD(gene name)|psi-mi:GSTCD(display_short)	psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702985|imex:IM-22632-852	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530550.1|refseq:XP_011530551.1|refseq:XP_011530554.1|refseq:NP_001026890.2|refseq:NP_079027.2|refseq:XP_005263279.1|ensembl:ENSG00000138780(gene)|ensembl:ENST00000360505(transcript)|ensembl:ENST00000394728(transcript)|ensembl:ENST00000515279(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR025714|interpro:IPR029063|interpro:IPR036282|mint:Q8NEC7|entrezgene/locuslink:79807(identity)|refseq:NM_001031720.3(identity)	refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695|entrezgene/locuslink:27071(identity)|refseq:NM_014395.2(identity)	-	comment:mint|comment:homomint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:jg34D624i8iGCgGTedM+tfGgmRQ9606	rogid:YYI49xKbndaB1MfL/QEovp2BF009606	intact-crc:7AE30794CD91ABA8|rigid:GL8qLK2JpbW+QJRfYnJ+dUsCKrA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:Q8NBZ0	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-769401|uniprotkb:Q6Y2K3|intact:EBI-28973946|ensembl:ENSP00000457016	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:in80e_human(display_long)|uniprotkb:CCDC95(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 95(gene name synonym)|uniprotkb:INO80E(gene name)|psi-mi:INO80E(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10702996|imex:IM-22632-853	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	refseq:NP_775889.1|ensembl:ENST00000562441|ensembl:ENSP00000456073|ensembl:ENSP00000457016|ensembl:ENST00000567065|ensembl:ENSP00000454665|ensembl:ENST00000620599|ensembl:ENSP00000484187|refseq:NP_001291491.1|refseq:NP_001291492.1|ensembl:ENSG00000169592(gene)|ensembl:ENST00000563197(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0031011"(Ino80 complex)|interpro:IPR026678|mint:Q8NBZ0|reactome:R-HSA-5689603|reactome:R-HSA-5696394|refseq:NM_173618.1(identity)|entrezgene/locuslink:283899(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:gGBXpYQkxY5mcF4I/4rTzjXZbG09606	intact-crc:272AFF0678E3501A|rigid:ZwG5jk9RbuQYwPghTvOdp70W8RI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N6F8	uniprotkb:Q92569	intact:EBI-8487781|intact:MINT-8417729|ensembl:ENSP00000297873	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:met27_human(display_long)|uniprotkb:METTL27(gene name)|psi-mi:METTL27(display_short)|uniprotkb:WBSCR27(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 27 protein(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703029|imex:IM-22632-856	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_689772.2|ensembl:ENSG00000165171(gene)|ensembl:ENST00000297873(transcript)|go:"GO:0008168"(methyltransferase activity)|interpro:IPR029063|interpro:IPR041698|mint:Q8N6F8|refseq:NM_152559.2(identity)|entrezgene/locuslink:155368(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	comment:mint|comment:homomint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:T+4JBqFxUvWNzHLf1bT6SGLCaJs9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:AF4C6508AEE908C6|rigid:i8+QJHaDs3uOblDGVBIEw3h7VDw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q8N7B6-2	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-10694433|ensembl:ENSP00000295290|ensembl:ENSP00000354171|ensembl:ENSP00000423477|ensembl:ENSP00000423536|ensembl:ENSP00000425938	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:q8n7b6-2(display_long)|uniprotkb:PACRGL(gene name)|psi-mi:PACRGL(display_short)|uniprotkb:C4orf28(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703018|imex:IM-22632-855	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	ensembl:ENSG00000163138(gene)|ensembl:ENST00000295290(transcript)|ensembl:ENST00000360916(transcript)|ensembl:ENST00000467997(transcript)|ensembl:ENST00000506702(transcript)|ensembl:ENST00000507634(transcript)|intact:EBI-3925298(isoform-parent)|uniprotkb:Q8N7B6-2(isoform-parent)|entrezgene/locuslink:133015(identity)|refseq:NM_145048.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:ggQEVTS6If4Zi1nkqpe4Lg/Ages9606	intact-crc:AF174A7B49E48CAC|rigid:D+pHjLy4yZv3SzSbWWPoPv32Qrs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NBB4	uniprotkb:Q9NP31	intact:EBI-5292994|uniprotkb:Q3B798|uniprotkb:Q6WLH8|uniprotkb:Q86WS8|ensembl:ENSP00000282326	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:zsca1_human(display_long)|uniprotkb:ZSCAN1(gene name)|psi-mi:ZSCAN1(display_short)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703007|imex:IM-22632-854	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_872378.3|ensembl:ENSG00000152467(gene)|ensembl:ENST00000282326(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR038269|refseq:NM_182572.3(identity)|entrezgene/locuslink:284312(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:WR2G0UBcX3kvOdwdBzRYAEmtJs09606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:98A558095DB3D3F9|rigid:hwJplR7pG7yCcy7J3GHFoT3DfjQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08631-2	uniprotkb:Q8N5V2	intact:EBI-9834454|ensembl:ENSP00000429848|ensembl:ENSP00000486627	intact:EBI-718372|uniprotkb:B9A045|uniprotkb:Q53QQ4|uniprotkb:Q53ST7|uniprotkb:Q6GMQ5|uniprotkb:Q9NQD6|uniprotkb:B4DMB8|uniprotkb:E9PC42|ensembl:ENSP00000264051	psi-mi:p08631-2(display_long)|uniprotkb:p59-HCK(isoform synonym)|uniprotkb:p59Hck(isoform synonym)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:ngef_human(display_long)|uniprotkb:Eph-interacting exchange protein(gene name synonym)|uniprotkb:Neuronal guanine nucleotide exchange factor(gene name synonym)|uniprotkb:NGEF(gene name)|psi-mi:NGEF(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703040|imex:IM-22632-857	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:P08631-2(isoform-parent)|intact:EBI-346340(isoform-parent)|ensembl:ENSG00000101336(gene)|ensembl:ENST00000520553(transcript)|ensembl:ENST00000629881(transcript)|entrezgene/locuslink:3055(identity)|refseq:NM_001172129.1(identity)	refseq:NP_001107562.1|refseq:NP_062824.2|refseq:XP_011509225.1|ensembl:ENSG00000066248(gene)|ensembl:ENST00000264051(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030426"(growth cone)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035635|interpro:IPR035899|interpro:IPR036028|mint:Q8N5V2|reactome:R-HSA-193648|reactome:R-HSA-3928663|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|go:"GO:0005829"(cytosol)|entrezgene/locuslink:25791(identity)|refseq:NM_019850.2(identity)	-	isoform-comment:Initiator Met-1 is removed. Contains a N-myristoyl glycine at position 2. Contains a S-palmitoyl cysteine at position 3.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:qSgfntp+jqdyi7qsc7u7UA7ylO09606	rogid:oAu+8njDslYpqxQaq85zzC3hb209606	intact-crc:429DD88ADD7E1EC9|rigid:c4kGJsbqoHwnyhenYr8kDMfU2AI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N485	uniprotkb:Q8NEU8	intact:EBI-10694501|uniprotkb:Q8N7I2|uniprotkb:A8K4R9|ensembl:ENSP00000274382	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	psi-mi:lix1_human(display_long)|uniprotkb:LIX1(gene name)|psi-mi:LIX1(display_short)|uniprotkb:C5orf11(gene name synonym)	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703051|imex:IM-22632-858	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694966.3|ensembl:ENSG00000145721(gene)|ensembl:ENST00000274382(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR029270|refseq:NM_153234.4(identity)|entrezgene/locuslink:167410(identity)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:l+3u4U0RlFJKO3tqAsJ0fLKqzoo9606	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	intact-crc:BED1375BE11FE5D5|rigid:sgjKaX7Imn5yS93f1aeq0w6YCDE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZW8	uniprotkb:O15460-2	intact:EBI-7543499|intact:MINT-1493010|uniprotkb:Q96JV4|uniprotkb:Q8WV64|uniprotkb:A6NMJ7|uniprotkb:Q71RB7|ensembl:ENSP00000254051	intact:EBI-10182841|ensembl:ENSP00000353772|ensembl:ENSP00000368379|ensembl:ENSP00000368394	psi-mi:tens4_human(display_long)|uniprotkb:TNS4(gene name)|psi-mi:TNS4(display_short)|uniprotkb:CTEN(gene name synonym)|uniprotkb:PP14434(orf name)|uniprotkb:C-terminal tensin-like protein(gene name synonym)	psi-mi:o15460-2(display_long)|uniprotkb:Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2(gene name synonym)|uniprotkb:UNQ290/PRO330(orf name)|uniprotkb:P4HA2(gene name)|psi-mi:P4HA2(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703062|imex:IM-22632-859	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116254.4|ensembl:ENSG00000131746(gene)|ensembl:ENST00000254051(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0008104"(protein localization)|interpro:IPR000980(SH2 motif)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR033929|interpro:IPR036860|mint:Q8IZW8|reactome:R-HSA-8875513|refseq:NM_032865.5(identity)|entrezgene/locuslink:84951(identity)	ensembl:ENSG00000072682(gene)|ensembl:ENST00000360568(transcript)|ensembl:ENST00000379086(transcript)|ensembl:ENST00000379100(transcript)|intact:EBI-348033(isoform-parent)|uniprotkb:O15460-2(isoform-parent)|refseq:NM_001017974.1(identity)|entrezgene/locuslink:8974(identity)	-	comment:mint|function:"May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3"	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:k439rXw6HuByQ+t4anCFT0Q23us9606	rogid:YndwsjPs3tNpYhzRLkuABcY2+549606	intact-crc:688FC631F5756CE6|rigid:WP/tQSw+aJD43GCqvfmcRxFYGv0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZW8	uniprotkb:P27986-2	intact:EBI-7543499|intact:MINT-1493010|uniprotkb:Q96JV4|uniprotkb:Q8WV64|uniprotkb:A6NMJ7|uniprotkb:Q71RB7|ensembl:ENSP00000254051	intact:EBI-9090282|ensembl:ENSP00000338554	psi-mi:tens4_human(display_long)|uniprotkb:TNS4(gene name)|psi-mi:TNS4(display_short)|uniprotkb:CTEN(gene name synonym)|uniprotkb:PP14434(orf name)|uniprotkb:C-terminal tensin-like protein(gene name synonym)	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703095|imex:IM-22632-862	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116254.4|ensembl:ENSG00000131746(gene)|ensembl:ENST00000254051(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0008104"(protein localization)|interpro:IPR000980(SH2 motif)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR033929|interpro:IPR036860|mint:Q8IZW8|reactome:R-HSA-8875513|refseq:NM_032865.5(identity)|entrezgene/locuslink:84951(identity)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	-	comment:mint|function:"May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3"	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:k439rXw6HuByQ+t4anCFT0Q23us9606	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	intact-crc:3374CA3B91588813|rigid:+lSZd9O464pLojaIzScnwivqPcQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZW8	uniprotkb:O00746	intact:EBI-7543499|intact:MINT-1493010|uniprotkb:Q96JV4|uniprotkb:Q8WV64|uniprotkb:A6NMJ7|uniprotkb:Q71RB7|ensembl:ENSP00000254051	intact:EBI-744871|uniprotkb:Q5U0M9|ensembl:ENSP00000219479|uniprotkb:A2IDD0	psi-mi:tens4_human(display_long)|uniprotkb:TNS4(gene name)|psi-mi:TNS4(display_short)|uniprotkb:CTEN(gene name synonym)|uniprotkb:PP14434(orf name)|uniprotkb:C-terminal tensin-like protein(gene name synonym)	psi-mi:ndkm_human(display_long)|uniprotkb:nm23-H4(gene name synonym)|uniprotkb:Nucleoside diphosphate kinase D(gene name synonym)|uniprotkb:NME4(gene name)|psi-mi:NME4(display_short)|uniprotkb:NM23D(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703084|imex:IM-22632-861	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116254.4|ensembl:ENSG00000131746(gene)|ensembl:ENST00000254051(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0008104"(protein localization)|interpro:IPR000980(SH2 motif)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR033929|interpro:IPR036860|mint:Q8IZW8|reactome:R-HSA-8875513|refseq:NM_032865.5(identity)|entrezgene/locuslink:84951(identity)	refseq:NP_001273362.1|refseq:NP_001273364.1|refseq:NP_001273365.1|refseq:NP_001273367.1|refseq:NP_001273368.1|refseq:NP_001273369.1|refseq:NP_005000.1|ensembl:ENSG00000103202(gene)|ensembl:ENST00000219479(transcript)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006869"(lipid transport)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:O00746|rcsb pdb:1EHW|reactome:R-HSA-499943|refseq:NM_005009.2(identity)|entrezgene/locuslink:4833(identity)	-	comment:mint|function:"May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3"	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:k439rXw6HuByQ+t4anCFT0Q23us9606	rogid:ybA9I8oT+oz1iuGLHT7WR1SAaKY9606	intact-crc:AC83EB7B0CF6EAEC|rigid:wAiIdSFqzQvz5Uvqd9LZJMXiEnY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZW8	uniprotkb:Q8NEC7	intact:EBI-7543499|intact:MINT-1493010|uniprotkb:Q96JV4|uniprotkb:Q8WV64|uniprotkb:A6NMJ7|uniprotkb:Q71RB7|ensembl:ENSP00000254051	intact:EBI-8469616|intact:MINT-6779113|uniprotkb:Q9H8S3|uniprotkb:A8MVD3|uniprotkb:A8K8J0|uniprotkb:H9KV97|ensembl:ENSP00000353695|ensembl:ENSP00000378216|ensembl:ENSP00000422354	psi-mi:tens4_human(display_long)|uniprotkb:TNS4(gene name)|psi-mi:TNS4(display_short)|uniprotkb:CTEN(gene name synonym)|uniprotkb:PP14434(orf name)|uniprotkb:C-terminal tensin-like protein(gene name synonym)	psi-mi:gstcd_human(display_long)|uniprotkb:GSTCD(gene name)|psi-mi:GSTCD(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703073|imex:IM-22632-860	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116254.4|ensembl:ENSG00000131746(gene)|ensembl:ENST00000254051(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0008104"(protein localization)|interpro:IPR000980(SH2 motif)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR033929|interpro:IPR036860|mint:Q8IZW8|reactome:R-HSA-8875513|refseq:NM_032865.5(identity)|entrezgene/locuslink:84951(identity)	refseq:XP_011530550.1|refseq:XP_011530551.1|refseq:XP_011530554.1|refseq:NP_001026890.2|refseq:NP_079027.2|refseq:XP_005263279.1|ensembl:ENSG00000138780(gene)|ensembl:ENST00000360505(transcript)|ensembl:ENST00000394728(transcript)|ensembl:ENST00000515279(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR025714|interpro:IPR029063|interpro:IPR036282|mint:Q8NEC7|entrezgene/locuslink:79807(identity)|refseq:NM_001031720.3(identity)	-	comment:mint|function:"May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3"	comment:mint|comment:homomint	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:k439rXw6HuByQ+t4anCFT0Q23us9606	rogid:jg34D624i8iGCgGTedM+tfGgmRQ9606	intact-crc:17576411343852EC|rigid:0o/vD8Aq2+oNEbAY1Tm7sTvr6yA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZS5	uniprotkb:P46108-2	intact:EBI-8477661|intact:MINT-8417707|uniprotkb:Q8IZS3|uniprotkb:Q8IZR9|uniprotkb:Q7Z2X5|uniprotkb:Q8IUL6|uniprotkb:Q8IZS1|uniprotkb:Q8IUM1	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:ofcc1_human(display_long)|uniprotkb:OFCC1(gene name)|psi-mi:OFCC1(display_short)|uniprotkb:MRDS1(gene name synonym)|uniprotkb:Orofacial clefting chromosomal breakpoint region candidate 1 protein(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703117|imex:IM-22632-864	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR031390|mint:Q8IZS5|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:XM_003118558.3(identity)|entrezgene/locuslink:266553(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	comment:mint|comment:homomint	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:4cDMDdOlk+3FSJ96g5F+dQ5dIJw9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:11145E3CB15369CF|rigid:rj52/3zjxL697AhAoaoBVC2xt2o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZW8	uniprotkb:Q86UA6-6	intact:EBI-7543499|intact:MINT-1493010|uniprotkb:Q96JV4|uniprotkb:Q8WV64|uniprotkb:A6NMJ7|uniprotkb:Q71RB7|ensembl:ENSP00000254051	intact:EBI-10691610|ensembl:ENSP00000439939	psi-mi:tens4_human(display_long)|uniprotkb:TNS4(gene name)|psi-mi:TNS4(display_short)|uniprotkb:CTEN(gene name synonym)|uniprotkb:PP14434(orf name)|uniprotkb:C-terminal tensin-like protein(gene name synonym)	psi-mi:q86ua6-6(display_long)|uniprotkb:RPAIN(gene name)|psi-mi:RPAIN(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Delta3(isoform synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703106|imex:IM-22632-863	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116254.4|ensembl:ENSG00000131746(gene)|ensembl:ENST00000254051(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0008104"(protein localization)|interpro:IPR000980(SH2 motif)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR033929|interpro:IPR036860|mint:Q8IZW8|reactome:R-HSA-8875513|refseq:NM_032865.5(identity)|entrezgene/locuslink:84951(identity)	intact:EBI-3907663(isoform-parent)|ensembl:ENSG00000129197(gene)|ensembl:ENST00000536255(transcript)|refseq:NM_001160246.1(identity)|entrezgene/locuslink:84268(identity)	-	comment:mint|function:"May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3"	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2018/04/06	rogid:k439rXw6HuByQ+t4anCFT0Q23us9606	rogid:O1pqZEoKwTB9kuzAQJM5x81s9z09606	intact-crc:DDED0839C4F9AD95|rigid:Ouc5emBEu2sqbtG+dUGqWoqywTQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZQ1	uniprotkb:Q5R372-2	intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888	intact:EBI-10692254|ensembl:ENSP00000350027	psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym)	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703139|imex:IM-22632-866	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N|refseq:NM_014991.4(identity)|entrezgene/locuslink:23001(identity)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	intact-crc:457ABBA458469ADC|rigid:VzVtsQelsn1zTXFO3MIa7+rDOGE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZQ1	uniprotkb:P62993	intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703128|imex:IM-22632-865	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N|refseq:NM_014991.4(identity)|entrezgene/locuslink:23001(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:D5ADB83BF821BF97|rigid:ADQ5EC6mrVV+lARfPHBz/t2Awzw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q8IXK0	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-713786|uniprotkb:Q8N306|uniprotkb:Q8TAG8|uniprotkb:A1L4Q1|uniprotkb:Q2TAL3|uniprotkb:Q5T0C1|uniprotkb:Q6NUJ6|uniprotkb:Q6ZQR1|uniprotkb:Q96BL4|uniprotkb:Q9Y4Y7|ensembl:ENSP00000257118|uniprotkb:D3DPR2|uniprotkb:A8KA40	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:phc2_human(display_long)|uniprotkb:Early development regulatory protein 2(gene name synonym)|uniprotkb:PHC2(gene name)|psi-mi:PHC2(display_short)|uniprotkb:EDR2(gene name synonym)|uniprotkb:PH2(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703161|imex:IM-22632-868	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	interpro:IPR038603|mint:Q8IXK0|reactome:R-HSA-2559580|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-8939243|reactome:R-HSA-8943724|interpro:IPR013761(Sterile alpha motif-type)|ensembl:ENSG00000134686(gene)|ensembl:ENST00000257118(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR012313(Zinc finger, FCS-type)|refseq:NP_004418.2|refseq:NP_932157.1|refseq:XP_016856005.1|refseq:XP_016856006.1|refseq:XP_016856007.1|refseq:XP_005270627.1|dip:DIP-34464N|refseq:NM_004427.3(identity)|entrezgene/locuslink:1912(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:7si/KU2tHoxviuCr70ncQERDWmY9606	intact-crc:39A87DA4711DAD3C|rigid:rweX3ifXQKh4XcxvdE90M+rBsWQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZQ1	uniprotkb:P40763	intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703150|imex:IM-22632-867	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N|refseq:NM_014991.4(identity)|entrezgene/locuslink:23001(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:5D8FDB6D1A00D924|rigid:g0CGpe0D+y9jus/7GcA3GSvbegE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q86UA6-6	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-10691610|ensembl:ENSP00000439939	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:q86ua6-6(display_long)|uniprotkb:RPAIN(gene name)|psi-mi:RPAIN(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Delta3(isoform synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703172|imex:IM-22632-869	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	intact:EBI-3907663(isoform-parent)|ensembl:ENSG00000129197(gene)|ensembl:ENST00000536255(transcript)|refseq:NM_001160246.1(identity)|entrezgene/locuslink:84268(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2018/04/06	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:O1pqZEoKwTB9kuzAQJM5x81s9z09606	intact-crc:B4DD476ABC68D4B0|rigid:E2RliB9b8z6O2Ftx0LItjt/eqAc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q8NEA6	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-744456|uniprotkb:B1AL19|uniprotkb:Q1PHK5|ensembl:ENSP00000325494|ensembl:ENSP00000507306	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:glis3_human(display_long)|uniprotkb:GLI-similar 3(gene name synonym)|uniprotkb:Zinc finger protein 515(gene name synonym)|uniprotkb:GLIS3(gene name)|psi-mi:GLIS3(display_short)|uniprotkb:ZNF515(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703183|imex:IM-22632-870	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	refseq:NP_001035878.1|refseq:NP_689842.3|refseq:XP_011516065.1|refseq:XP_011516066.1|refseq:XP_011516068.1|ensembl:ENSP00000325494|ensembl:ENST00000381971|ensembl:ENSP00000371398|ensembl:ENSP00000507306|refseq:XP_005251443.1|ensembl:ENSG00000107249(gene)|ensembl:ENST00000324333(transcript)|ensembl:ENST00000682749(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030405|interpro:IPR036236|interpro:IPR043359|mint:Q8NEA6|refseq:XP_016869850.1|entrezgene/locuslink:169792(identity)|refseq:NM_152629.3(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:Lw/ndmcKfz+wO+0eEheRj4Y0fXM9606	intact-crc:D11C85C407E028D0|rigid:yBlDubrY5sRWHXtbBC/jyec5wDM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q8IXS0	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-10694567|uniprotkb:Q5JYK1|ensembl:ENSP00000274673	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:f217a_human(display_long)|uniprotkb:FAM217A(gene name)|psi-mi:FAM217A(display_short)|uniprotkb:C6orf146(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703194|imex:IM-22632-871	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	refseq:NP_775834.2|ensembl:ENSG00000145975(gene)|ensembl:ENST00000274673(transcript)|interpro:IPR029266|entrezgene/locuslink:222826(identity)|refseq:NM_173563.2(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:i3Q9Q5yfPqGDHqLSl7386JGPO989606	intact-crc:7ACC2913147F0033|rigid:Zx8dGOJxsJFOsfBn+GjqQhNFqGw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	intact:EBI-10696557	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	-	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:arap3(display_short)|psi-mi:EBI-10696557(display_long)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703205|imex:IM-22632-872	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	entrezgene/locuslink:64411(identity)|refseq:XM_005268499.1(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	no-uniprot-update:	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:77y7xZURYh8VActT4V+Oof5AWxY9606	intact-crc:510244566C794F9E|rigid:7nplytXoxcbohqlE7aA41HcI6qc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:O14569	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-717654|uniprotkb:A8K552|ensembl:ENSP00000232508|ensembl:ENSP00000391209|ensembl:ENSP00000400454|ensembl:ENSP00000410663	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:c56d2_human(display_long)|uniprotkb:Putative tumor suppressor protein 101F6(gene name synonym)|uniprotkb:CYB561D2(gene name)|psi-mi:CYB561D2(display_short)|uniprotkb:101F6(gene name synonym)|uniprotkb:LUCA12.2(orf name)|uniprotkb:Cytochrome b561 domain-containing protein 2(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703216|imex:IM-22632-873	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	refseq:NP_001278213.1|refseq:NP_008953.1|ensembl:ENSG00000114395(gene)|ensembl:ENST00000232508(transcript)|ensembl:ENST00000418577(transcript)|ensembl:ENST00000424512(transcript)|ensembl:ENST00000425346(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031982"(vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0140571"(transmembrane ascorbate ferrireductase activity)|go:"GO:0140575"(transmembrane monodehydroascorbate reductase activity)|go:"GO:0140576"(ascorbate homeostasis)|interpro:IPR006593(Cytochrome b561 / ferric reductase transmembrane)|entrezgene/locuslink:11068(identity)|refseq:NM_001291284.1(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:FPgiTQqW5MUC5+i2RxE1jq6lkSs9606	intact-crc:DC43F62F928EB086|rigid:tDt12o+Dmi8zMIFSg4rfmcnJhCY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:O75208	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-724524|uniprotkb:Q7L5V7|uniprotkb:Q7Z5T6|uniprotkb:Q8NBL4|uniprotkb:Q9NTJ2|uniprotkb:Q9P056|uniprotkb:A8K3L2|ensembl:ENSP00000262507	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:coq9_human(display_long)|uniprotkb:COQ9(gene name)|psi-mi:COQ9(display_short)|uniprotkb:C16orf49(gene name synonym)|uniprotkb:HSPC326(orf name)|uniprotkb:PSEC0129(orf name)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703227|imex:IM-22632-874	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	refseq:NP_064708.1|ensembl:ENSG00000088682(gene)|ensembl:ENST00000262507(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006744"(ubiquinone biosynthetic process)|go:"GO:0008289"(lipid binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR012762(Ubiquinone biosynthesis protein COQ9)|interpro:IPR013718(COQ9)|rcsb pdb:4RHP|rcsb pdb:6AWL|rcsb pdb:6DEW|reactome:R-HSA-2142789|entrezgene/locuslink:57017(identity)|refseq:NM_020312.3(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:Jsv3JHc6FiNNH18LONTL34OsHoE9606	intact-crc:4EEE330E3F30FD08|rigid:e7oJ15jZJBA4rXg8lxaliiS6FaQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7L591-3	uniprotkb:P46108-2	intact:EBI-10694655|ensembl:ENSP00000325174	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703249|imex:IM-22632-876	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:2A8FE539A62D53AD|rigid:qB1AeYj64SqTd75NWEsFISg6HF0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q7Z417	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703238|imex:IM-22632-875	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417|entrezgene/locuslink:57532(identity)|refseq:NM_020772.2(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	intact-crc:8361C05096098AAC|rigid:/wMZ2ZkhAS7NfHMscfAQA5O1wtY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99704	uniprotkb:Q7L591-3	intact:EBI-1384360|uniprotkb:O43204|uniprotkb:Q53TY2|uniprotkb:Q9UHG6|ensembl:ENSP00000233668	intact:EBI-10694655|ensembl:ENSP00000325174	psi-mi:dok1_human(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:pp62(gene name synonym)|uniprotkb:DOK1(gene name)|psi-mi:DOK1(display_short)	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703271|imex:IM-22632-878	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001184189.1|refseq:NP_001372.1|refseq:NP_001305797.1|ensembl:ENSG00000115325(gene)|ensembl:ENST00000233668(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:Q99704|rcsb pdb:2V76|reactome:R-HSA-8849469|reactome:R-HSA-8853659|refseq:NM_001381.3(identity)|entrezgene/locuslink:1796(identity)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	-	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Pvjez+wIa3gWdY9ZYvWN6lmOM4o9606	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	intact-crc:AF7CB76B0FB4FDEC|rigid:W6uSydVrqZuMHlPUfXjuH/8Lb6E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7L591-3	uniprotkb:P46108	intact:EBI-10694655|ensembl:ENSP00000325174	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703260|imex:IM-22632-877	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:107CD1AE83CBCD9B|rigid:gDluw/pMUSTDuPy6NyJFOL7538I	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7L591-3	uniprotkb:Q9UKG1	intact:EBI-10694655|ensembl:ENSP00000325174	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703293|imex:IM-22632-880	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:D5924603EB8435AE|rigid:X4itx5kKv6mopcG0Dv+czzH7oAM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7L591-3	uniprotkb:O60496	intact:EBI-10694655|ensembl:ENSP00000325174	intact:EBI-1046024|uniprotkb:Q8N5A4|ensembl:ENSP00000276420	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:dok2_human(display_long)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:DOK2(gene name)|psi-mi:DOK2(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703282|imex:IM-22632-879	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	refseq:NP_003965.2|ensembl:ENSG00000147443(gene)|ensembl:ENST00000276420(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|rcsb pdb:2D9W|rcsb pdb:2DLW|reactome:R-HSA-210993|reactome:R-HSA-8853659|go:"GO:0007166"(cell surface receptor signaling pathway)|entrezgene/locuslink:9046(identity)|refseq:NM_003974.2(identity)	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	rogid:gBEpjlq3kc6oYF0uVqPz04hfrHw9606	intact-crc:0D406470BA69C0CF|rigid:r3ULyM8s5p+wI0BvVlurOy9GIKg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q6P1J6-2	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-10694821	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:q6p1j6-2(display_long)|uniprotkb:PLB1(gene name)|psi-mi:PLB1(display_short)|uniprotkb:PLB(gene name synonym)|uniprotkb:Phospholipase B/lipase(gene name synonym)|uniprotkb:Lysophospholipase(gene name synonym)|uniprotkb:Phospholipase A2(gene name synonym)|uniprotkb:Triacylglycerol lipase(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703304|imex:IM-22632-881	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	intact:EBI-10757275(isoform-parent)|uniprotkb:Q6P1J6-2(isoform-parent)|refseq:NM_153021.4(identity)|entrezgene/locuslink:151056(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FYN (P06241), JAK2 (O60674), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:WLweRT1dlb70eDlX6qsoWBzXA6c9606	intact-crc:BC0DD200940307C0|rigid:tYRSWsXsHC6ynRtdQUyUGqsCBHg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5VZ18	uniprotkb:Q7L591-3	intact:EBI-3956977|uniprotkb:Q8TEQ5|ensembl:ENSP00000307369	intact:EBI-10694655|ensembl:ENSP00000325174	psi-mi:she_human(display_long)|uniprotkb:SHE(gene name)|psi-mi:SHE(display_short)	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703315|imex:IM-22632-882	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011507465.1|refseq:NP_001010846.1|ensembl:ENSG00000169291(gene)|ensembl:ENST00000304760(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|interpro:IPR000980(SH2 motif)|interpro:IPR035041|interpro:IPR035042|interpro:IPR036860|entrezgene/locuslink:126669(identity)|refseq:NM_001010846.2(identity)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	-	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:ZN2ORmTe7ETaKpdPvYPJP3yQKbI9606	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	intact-crc:B66A4E9A1D4D7960|rigid:W6BSb2ABqT7jK74A3/KflHd3mrc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5VU92	uniprotkb:Q9NP31	intact:EBI-10694873|uniprotkb:Q8IYK3|ensembl:ENSP00000360167	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:dc121_human(display_long)|uniprotkb:DCAF12L1(gene name)|psi-mi:DCAF12L1(display_short)|uniprotkb:WD repeat-containing protein 40B(gene name synonym)|uniprotkb:WDR40B(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703326|imex:IM-22632-883	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_848565.2|ensembl:ENSG00000198889(gene)|ensembl:ENST00000371126(transcript)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|entrezgene/locuslink:139170(identity)|refseq:NM_178470.4(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:n9k7CP2cQy1nTJU2wnezEdfYARk9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:7A40A6D9C26A235E|rigid:ghSVX+bUay7Dm61mUSviSIv68hg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5R372-2	uniprotkb:Q03112	intact:EBI-10692254|ensembl:ENSP00000350027	intact:EBI-1384862|uniprotkb:Q16122|uniprotkb:Q99917|uniprotkb:C9JAK0|uniprotkb:Q5HYI1|uniprotkb:Q6MZS6|uniprotkb:Q8NEI5|uniprotkb:A1L4F3|uniprotkb:A8KA00|uniprotkb:B7Z8W7|uniprotkb:B7ZLQ3|uniprotkb:B7ZLQ4|uniprotkb:D3DNP7|ensembl:ENSP00000417899|intact:EBI-8475192|intact:MINT-8417693|uniprotkb:E7EQ57|uniprotkb:Q13465|uniprotkb:Q13466|uniprotkb:Q6FH90	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:mecom_human(display_long)|uniprotkb:MECOM(gene name)|psi-mi:MECOM(display_short)|uniprotkb:EVI1(gene name synonym)|uniprotkb:Ecotropic virus integration site 1 protein homolog(gene name synonym)|uniprotkb:MDS1(gene name synonym)|uniprotkb:Myelodysplasia syndrome 1 protein(gene name synonym)|uniprotkb:Myelodysplasia syndrome-associated protein 1(gene name synonym)|uniprotkb:MDS1 and EVI1 complex locus protein(gene name synonym)|uniprotkb:PRDM3(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703337|imex:IM-22632-884	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	refseq:NP_001098547.3|refseq:NP_001098548.2|refseq:NP_001157471.1|refseq:NP_001157472.1|refseq:NP_001192123.1|refseq:NP_004982.2|refseq:NP_005232.2|ensembl:ENSG00000085276(gene)|ensembl:ENST00000494292(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0071425"(hematopoietic stem cell proliferation)|interpro:IPR001214(SET)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR044411|mint:Q03112|rcsb pdb:6BW3|reactome:R-HSA-3214841|reactome:R-HSA-8943724|interpro:IPR036236|refseq:XP_016861363.1|refseq:XP_016861364.1|refseq:XP_016861365.1|refseq:XP_005247278.1|refseq:XP_005247280.1|refseq:XP_005247272.1|dip:DIP-38639N|refseq:XP_005247276.1|refseq:XP_005247277.1|entrezgene/locuslink:2122(identity)|refseq:XM_006713537.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), SYK (P43405)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2018/04/06	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	rogid:MAlEIuVZS4+BNoy50jejv2O30WA9606	intact-crc:F4DB0EB12B937268|rigid:bqT3Gw/k0vuCcK2LncEvdXLqIo8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TAL5	uniprotkb:Q5R372-2	intact:EBI-10694291|ensembl:ENSP00000288462|ensembl:ENSP00000363280	intact:EBI-10692254|ensembl:ENSP00000350027	psi-mi:ci043_human(display_long)|uniprotkb:C9orf43(gene name)|psi-mi:C9orf43(display_short)	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703348|imex:IM-22632-885	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001265558.1|refseq:NP_689999.1|ensembl:ENSG00000157653(gene)|ensembl:ENST00000288462(transcript)|ensembl:ENST00000374165(transcript)|interpro:IPR029134|mint:Q8TAL5|refseq:NM_001278629.1(identity)|entrezgene/locuslink:257169(identity)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FES (P07332)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:LGnLEmC1sPfnq+qr2b3M7cEccek9606	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	intact-crc:05D771C06D6451B1|rigid:eJUhhZkMvQnZauEbWk6gp5iT7IQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BRT2	uniprotkb:Q5R372-2	intact:EBI-1054584|uniprotkb:B2R4I0|ensembl:ENSP00000476140	intact:EBI-10692254|ensembl:ENSP00000350027	psi-mi:uqcc2_human(display_long)|uniprotkb:UQCC2(gene name)|psi-mi:UQCC2(display_short)|uniprotkb:Breast cancer-associated protein SGA-81M(gene name synonym)|uniprotkb:C6orf125(gene name synonym)|uniprotkb:MNF1(gene name synonym)|uniprotkb:Mitochondrial nucleoid factor 1(gene name synonym)|uniprotkb:Mitochondrial protein M19(gene name synonym)	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703359|imex:IM-22632-886	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115716.1|ensembl:ENSG00000137288(gene)|ensembl:ENST00000607484(transcript)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR037698|entrezgene/locuslink:84300(identity)|refseq:NM_032340.3(identity)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FRK (P42685), JAK2 (O60674)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:5bqVcfnTXOCOuCVCrEtzEaChT3Y9606	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	intact-crc:D13708BEDB5A99E0|rigid:84TByNxiPI39K8UiTjQ4a0pPJUg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15027	uniprotkb:Q5R372-2	intact:EBI-751746|uniprotkb:Q53XN9|ensembl:ENSP00000158762|ensembl:ENSP00000499859	intact:EBI-10692254|ensembl:ENSP00000350027	psi-mi:acap1_human(display_long)|uniprotkb:ACAP1(gene name)|psi-mi:ACAP1(display_short)|uniprotkb:Centaurin-beta-1(gene name synonym)|uniprotkb:CENTB1(gene name synonym)|uniprotkb:KIAA0050(gene name synonym)	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703370|imex:IM-22632-887	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055531.1|interpro:IPR038508|mint:Q15027|rcsb pdb:3JUE|rcsb pdb:3T9K|rcsb pdb:4CKG|rcsb pdb:4CKH|rcsb pdb:4F1P|rcsb pdb:4NSW|rcsb pdb:5H3D|ensembl:ENSG00000072818(gene)|ensembl:ENSG00000288169(gene)|ensembl:ENST00000158762(transcript)|ensembl:ENST00000672212(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR036770|interpro:IPR037278|entrezgene/locuslink:9744(identity)|refseq:NM_014716.3(identity)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:pdHptA2uWwLfGAtHieVj+hm1udw9606	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	intact-crc:0A4EB808F2CC2B4A|rigid:xDCTGDNaTukiYh5nmSa+yDL4I/Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16643	uniprotkb:Q5R372-2	intact:EBI-351394|uniprotkb:Q9UFZ5|uniprotkb:B2RBG0|ensembl:ENSP00000308532|intact:EBI-4404710|uniprotkb:A8MV58	intact:EBI-10692254|ensembl:ENSP00000350027	psi-mi:dreb_human(display_long)|uniprotkb:DBN1(gene name)|psi-mi:DBN1(display_short)|uniprotkb:Developmentally-regulated brain protein(gene name synonym)|uniprotkb:D0S117E(gene name synonym)	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703381|imex:IM-22632-888	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004386.2|refseq:NP_543157.1|refseq:XP_005265884.1|ensembl:ENSG00000113758(gene)|ensembl:ENST00000309007(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0042641"(actomyosin)|go:"GO:0030425"(dendrite)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051015"(actin filament binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028438|interpro:IPR029006|mint:Q16643|go:"GO:0030426"(growth cone)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031915"(positive regulation of synaptic plasticity)|rcsb pdb:5Y1Z|rcsb pdb:5ZZ9|reactome:R-HSA-9013405|reactome:R-HSA-9013407|reactome:R-HSA-9013418|reactome:R-HSA-9013422|go:"GO:0032507"(maintenance of protein location in cell)|refseq:XP_016864629.1|refseq:NM_004395.3(identity)|entrezgene/locuslink:1627(identity)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:0+VPJM5mTuG2jzmzGG3iLswmCUc9606	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	intact-crc:61D70E3AB167743A|rigid:nxiJ4OTRMOsHHb53mH8iovFyeaE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5R372-2	uniprotkb:Q8N6T3-3	intact:EBI-10692254|ensembl:ENSP00000350027	intact:EBI-10694449|ensembl:ENSP00000359298	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:q8n6t3-3(display_long)|uniprotkb:ARFGAP1(gene name)|psi-mi:ARFGAP1(display_short)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)|uniprotkb:ARF1GAP(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703392|imex:IM-22632-889	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	intact:EBI-716933(isoform-parent)|ensembl:ENSG00000101199(gene)|ensembl:ENST00000370275(transcript)|uniprotkb:Q8N6T3-3(isoform-parent)|refseq:NM_001281482.1(identity)|entrezgene/locuslink:55738(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	rogid:A38kI1kCOsmDVgNQTMQoGNKwOrs9606	intact-crc:6E69710C9A95ABA2|rigid:Kp+s0sSa1dHcrABVM7jk//yEykQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q5BJH2-2	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-10694905|ensembl:ENSP00000254742	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:q5bjh2-2(display_long)|uniprotkb:TMEM128(gene name)|psi-mi:TMEM128(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703403|imex:IM-22632-890	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	intact:EBI-10243515(isoform-parent)|ensembl:ENSG00000132406(gene)|ensembl:ENST00000254742(transcript)|uniprotkb:Q5BJH2-2(isoform-parent)|refseq:NM_032927.3(identity)|entrezgene/locuslink:85013(identity)	-	-	isoform-comment:No experimental confirmation available.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FYN (P06241), SYK (P43405)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:fsGbysnORUH/y9LqInPSyP55P4k9606	intact-crc:A2E1712A5A782F46|rigid:klLT6M6ns3E3y4A943lKESsyWbg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q3KNS6	uniprotkb:P40763	intact:EBI-4395439|uniprotkb:Q3KNS7|uniprotkb:Q6ZNN0|uniprotkb:Q7Z657|uniprotkb:A0A075B6T0|ensembl:ENSP00000429266	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:zn829_human(display_long)|uniprotkb:ZNF829(gene name)|psi-mi:ZNF829(display_short)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703425|imex:IM-22632-892	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011525235.1|refseq:NP_001032309.2|refseq:NP_001165450.1|refseq:XP_005258933.1|ensembl:ENSG00000185869(gene)|ensembl:ENST00000391711(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q3KNS6|refseq:NM_001037232.3(identity)|entrezgene/locuslink:374899(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:c0t+1le/UyFvSKKZAsToELKNZUE9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:0C89C7E19E646A7D|rigid:D9vrGftPWxiVmvWsNzat1m/P9vw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5BJH2-2	uniprotkb:Q13387	intact:EBI-10694905|ensembl:ENSP00000254742	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:q5bjh2-2(display_long)|uniprotkb:TMEM128(gene name)|psi-mi:TMEM128(display_short)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703414|imex:IM-22632-891	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-10243515(isoform-parent)|ensembl:ENSG00000132406(gene)|ensembl:ENST00000254742(transcript)|uniprotkb:Q5BJH2-2(isoform-parent)|refseq:NM_032927.3(identity)|entrezgene/locuslink:85013(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	isoform-comment:No experimental confirmation available.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:fsGbysnORUH/y9LqInPSyP55P4k9606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:814F1DE6CF4E59D0|rigid:dFpOkwbM+BaQW+GZi1bvd/dCBO8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q3KNS6	uniprotkb:Q9UKG1	intact:EBI-4395439|uniprotkb:Q3KNS7|uniprotkb:Q6ZNN0|uniprotkb:Q7Z657|uniprotkb:A0A075B6T0|ensembl:ENSP00000429266	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:zn829_human(display_long)|uniprotkb:ZNF829(gene name)|psi-mi:ZNF829(display_short)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703436|imex:IM-22632-893	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011525235.1|refseq:NP_001032309.2|refseq:NP_001165450.1|refseq:XP_005258933.1|ensembl:ENSG00000185869(gene)|ensembl:ENST00000391711(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q3KNS6|refseq:NM_001037232.3(identity)|entrezgene/locuslink:374899(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:c0t+1le/UyFvSKKZAsToELKNZUE9606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:686E5ADA5CA457EE|rigid:A8DhfdVGowL2AiKFoAua0wlJZzg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEU8	uniprotkb:Q3B8N2-2	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	intact:EBI-10694969|ensembl:ENSP00000315564	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:q3b8n2-2(display_long)|uniprotkb:LGALS9B(gene name)|psi-mi:LGALS9B(display_short)|uniprotkb:Galectin-9-like protein A(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703447|imex:IM-22632-894	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1|entrezgene/locuslink:55198(identity)|refseq:NM_018171.3(identity)	intact:EBI-10240775(isoform-parent)|ensembl:ENSG00000170298(gene)|ensembl:ENST00000324290(transcript)|uniprotkb:Q3B8N2-2(isoform-parent)|entrezgene/locuslink:654346(identity)|refseq:NM_001042685.1(identity)	-	-	isoform-comment:No experimental confirmation available.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FES (P07332), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	rogid:e44N/cll4hZr6nWfUMKICujSwgY9606	intact-crc:37543D97B20230BD|rigid:puYx2Ru+Xn7VyH6q1nUlwKbsGpo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q18PE1	uniprotkb:P46108-2	intact:EBI-3046647|ensembl:ENSP00000344432|uniprotkb:E9PB56|uniprotkb:Q8NBC1|uniprotkb:Q86XG5|uniprotkb:Q8N2J3|uniprotkb:A2A499|uniprotkb:Q6P6A6|uniprotkb:A2RRD4	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:dok7_human(display_long)|uniprotkb:DOK7(gene name)|psi-mi:DOK7(display_short)|uniprotkb:C4orf25(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 7(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703458|imex:IM-22632-895	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000175920(gene)|ensembl:ENST00000340083(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045202"(synapse)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037746|interpro:IPR037747|interpro:IPR037748|refseq:NP_001288000.1|refseq:NP_001158145.1|refseq:NP_775931.3|refseq:NP_001243825.1|refseq:NM_173660.4(identity)|entrezgene/locuslink:285489(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:RNSUGsyQVitqfrm+mTmzf0fZHR49606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:DD79FA3D9FBF3F23|rigid:Pf/NqA0c57coq6f8qfEpOUswHaE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q18PE1	uniprotkb:Q9UKG1	intact:EBI-3046647|ensembl:ENSP00000344432|uniprotkb:E9PB56|uniprotkb:Q8NBC1|uniprotkb:Q86XG5|uniprotkb:Q8N2J3|uniprotkb:A2A499|uniprotkb:Q6P6A6|uniprotkb:A2RRD4	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:dok7_human(display_long)|uniprotkb:DOK7(gene name)|psi-mi:DOK7(display_short)|uniprotkb:C4orf25(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 7(gene name synonym)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703469|imex:IM-22632-896	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000175920(gene)|ensembl:ENST00000340083(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045202"(synapse)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037746|interpro:IPR037747|interpro:IPR037748|refseq:NP_001288000.1|refseq:NP_001158145.1|refseq:NP_775931.3|refseq:NP_001243825.1|refseq:NM_173660.4(identity)|entrezgene/locuslink:285489(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:RNSUGsyQVitqfrm+mTmzf0fZHR49606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:40F85F9B388C34EC|rigid:CfjRkiU1yZ2FzBc9pnfYRjCVoAg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15672	uniprotkb:P40763	intact:EBI-1797287|uniprotkb:Q92487|uniprotkb:Q99804|uniprotkb:A4D128|ensembl:ENSP00000242261	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:twst1_human(display_long)|uniprotkb:H-twist(gene name synonym)|uniprotkb:TWIST1(gene name)|psi-mi:TWIST1(display_short)|uniprotkb:TWIST(gene name synonym)|uniprotkb:BHLHA38(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 38(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703480|imex:IM-22632-897	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000465.1|refseq:XP_011513798.1|dip:DIP-45974N|ensembl:ENSG00000122691(gene)|ensembl:ENST00000242261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0001843"(neural tube closure)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032502"(developmental process)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035359"(negative regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0060900"(embryonic camera-type eye formation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0070888"(E-box binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000276"(negative regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000780"(negative regulation of double-strand break repair)|go:"GO:2000793"(cell proliferation involved in heart valve development)|go:"GO:2000802"(positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015789(Twist)|interpro:IPR036638|rcsb pdb:2MJV|reactome:R-HSA-6785807|reactome:R-HSA-8878166|reactome:R-HSA-8939902|refseq:NM_000474.3(identity)|entrezgene/locuslink:7291(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:1+WEEh0ruAAKCxlJQCVzBqTrhIM9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:71A4701DDE87CF11|rigid:oPCUu5hV4Np0/jr8Ossb0icLo18	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q15435-3	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-10695066|ensembl:ENSP00000385022	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:q15435-3(display_long)|uniprotkb:PPP1R7(gene name)|psi-mi:PPP1R7(display_short)|uniprotkb:Protein phosphatase 1 regulatory subunit 22(gene name synonym)|uniprotkb:SDS22(gene name synonym)|uniprotkb:sds22beta1(isoform synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703491|imex:IM-22632-898	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	intact:EBI-1024281(isoform-parent)|ensembl:ENSG00000115685(gene)|ensembl:ENST00000406106(transcript)|uniprotkb:Q15435-3(isoform-parent)|entrezgene/locuslink:5510(identity)|refseq:NM_001282410.1(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:cJCKB1W0OoVTBEjlLdLVL2FKsJ49606	intact-crc:417321AC570A377E|rigid:3Mg+sXZdl58aNVPdfrmrU/2sbRM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q14847	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-742828|uniprotkb:Q96ED2|uniprotkb:Q96IG0|ensembl:ENSP00000325240|ensembl:ENSP00000392853|uniprotkb:B4DGQ0	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:lasp1_human(display_long)|uniprotkb:Metastatic lymph node gene 50 protein(gene name synonym)|uniprotkb:LASP1(gene name)|psi-mi:LASP1(display_short)|uniprotkb:MLN50(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703513|imex:IM-22632-900	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_006139.1|refseq:NP_001258537.1|ensembl:ENSG00000002834(gene)|ensembl:ENST00000318008(transcript)|ensembl:ENST00000435347(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006811"(ion transport)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|interpro:IPR000900(Nebulin 35 residue motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR035630|interpro:IPR036028|mint:Q14847|rcsb pdb:3I35|refseq:NM_006148.3(identity)|entrezgene/locuslink:3927(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:Oa+FdJXeQhahYTqVrHYk6yBrUWI9606	intact-crc:CFCF3899C36B6320|rigid:VZcThSwTkBHIDVT+XglGtwk1t98	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14847	uniprotkb:P46108-2	intact:EBI-742828|uniprotkb:Q96ED2|uniprotkb:Q96IG0|ensembl:ENSP00000325240|ensembl:ENSP00000392853|uniprotkb:B4DGQ0	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:lasp1_human(display_long)|uniprotkb:Metastatic lymph node gene 50 protein(gene name synonym)|uniprotkb:LASP1(gene name)|psi-mi:LASP1(display_short)|uniprotkb:MLN50(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703502|imex:IM-22632-899	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006139.1|refseq:NP_001258537.1|ensembl:ENSG00000002834(gene)|ensembl:ENST00000318008(transcript)|ensembl:ENST00000435347(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006811"(ion transport)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|interpro:IPR000900(Nebulin 35 residue motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR035630|interpro:IPR036028|mint:Q14847|rcsb pdb:3I35|refseq:NM_006148.3(identity)|entrezgene/locuslink:3927(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Oa+FdJXeQhahYTqVrHYk6yBrUWI9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:65B1FD740F31C3E6|rigid:hcvX0/4E4hxcqpSl1Md0hTxZOLI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14765	uniprotkb:P46108	intact:EBI-1186538|uniprotkb:Q96NZ6|ensembl:ENSP00000351255|ensembl:ENSP00000376134	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:stat4_human(display_long)|uniprotkb:STAT4(gene name)|psi-mi:STAT4(display_short)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703535|imex:IM-22632-902	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003142.1|refseq:XP_006712782.1|refseq:NP_001230764.1|refseq:XP_011510007.1|ensembl:ENSG00000138378(gene)|ensembl:ENST00000358470(transcript)|ensembl:ENST00000392320(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR029839|interpro:IPR035856|interpro:IPR036535|interpro:IPR036860|mint:Q14765|reactome:R-HSA-8854691|reactome:R-HSA-8950505|reactome:R-HSA-8984722|reactome:R-HSA-9020591|reactome:R-HSA-9020933|reactome:R-HSA-9020958|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-39854N|refseq:NM_001243835.1(identity)|entrezgene/locuslink:6775(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:z6Wvolbix1XQBOsVA/MIxXi56qU9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:2E51A0E18082CE2B|rigid:ZESLbDCf4OwArykDIKQPmGZ+Foc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14796	uniprotkb:Q14765	intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906	intact:EBI-1186538|uniprotkb:Q96NZ6|ensembl:ENSP00000351255|ensembl:ENSP00000376134	psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym)	psi-mi:stat4_human(display_long)|uniprotkb:STAT4(gene name)|psi-mi:STAT4(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703524|imex:IM-22632-901	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933|entrezgene/locuslink:117157(identity)|refseq:NM_053282.4(identity)	refseq:NP_003142.1|refseq:XP_006712782.1|refseq:NP_001230764.1|refseq:XP_011510007.1|ensembl:ENSG00000138378(gene)|ensembl:ENST00000358470(transcript)|ensembl:ENST00000392320(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR029839|interpro:IPR035856|interpro:IPR036535|interpro:IPR036860|mint:Q14765|reactome:R-HSA-8854691|reactome:R-HSA-8950505|reactome:R-HSA-8984722|reactome:R-HSA-9020591|reactome:R-HSA-9020933|reactome:R-HSA-9020958|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-39854N|refseq:NM_001243835.1(identity)|entrezgene/locuslink:6775(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606	rogid:z6Wvolbix1XQBOsVA/MIxXi56qU9606	intact-crc:D74B2BD618726309|rigid:/yz8FajxoBvSLsO4muNkEHW1arA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:Q15389-2	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-10692491|ensembl:ENSP00000297450	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:q15389-2(display_long)|uniprotkb:ANGPT1(gene name)|psi-mi:ANGPT1(display_short)|uniprotkb:KIAA0003(gene name synonym)|uniprotkb:Gly-269 del(isoform synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703557|imex:IM-22632-904	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	ensembl:ENSG00000154188(gene)|ensembl:ENST00000297450(transcript)|intact:EBI-2922365(isoform-parent)|entrezgene/locuslink:284(identity)|refseq:NM_001199859.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FRK (P42685), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:5Upmh3KuCcINYHtPCexkVUarKPw9606	intact-crc:02736EE9F1610543|rigid:t8VXeUmQHfGBMJcztWFm8VlzdwU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13829	uniprotkb:Q9UN19	intact:EBI-2505861|uniprotkb:B7Z6M4|uniprotkb:Q5TZQ1|ensembl:ENSP00000226225	intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602	psi-mi:bacd2_human(display_long)|uniprotkb:BACURD2(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein TNFAIP1(gene name synonym)|uniprotkb:Protein B12(gene name synonym)|uniprotkb:TNFAIP1(gene name)|psi-mi:TNFAIP1(display_short)|uniprotkb:EDP1(gene name synonym)|uniprotkb:Tumor necrosis factor, alpha-induced protein 1, endothelial(gene name synonym)	psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703546|imex:IM-22632-903	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066960.1|ensembl:ENSG00000109079(gene)|ensembl:ENST00000226225(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030332"(cyclin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q13829|reactome:R-HSA-9696264|reactome:R-HSA-9696270|refseq:NM_021137.4(identity)|entrezgene/locuslink:7126(identity)	refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695|entrezgene/locuslink:27071(identity)|refseq:NM_014395.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8vM9HnNmkirDbJRETV/TeE8pONY9606	rogid:YYI49xKbndaB1MfL/QEovp2BF009606	intact-crc:A71C610F466F9638|rigid:wZpWosAvbzNzLucW3qMxNwL5o/U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:Q9H7E9	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-715389|uniprotkb:A6NGC0|uniprotkb:Q96BT8|ensembl:ENSP00000330361	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:ch033_human(display_long)|uniprotkb:C8orf33(gene name)|psi-mi:C8orf33(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703579|imex:IM-22632-906	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	refseq:NP_075568.1|ensembl:ENSG00000182307(gene)|ensembl:ENST00000331434(transcript)|interpro:IPR029274|mint:Q9H7E9|refseq:NM_023080.2(identity)|entrezgene/locuslink:65265(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FRK (P42685)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:R2UNBJ/dYewCXrmuO3E9apROd+Q9606	intact-crc:52D40F78195F4C9E|rigid:EuHGROUDWN7FWLF0JH7Y0SuEbkE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:Q6P5X5-2	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-10692329	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:q6p5x5-2(display_long)|uniprotkb:C22orf39(gene name)|psi-mi:C22orf39(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703568|imex:IM-22632-905	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	intact:EBI-7317823(isoform-parent)|uniprotkb:Q6P5X5-2(isoform-parent)|entrezgene/locuslink:128977(identity)|refseq:NM_001166242.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FRK (P42685), PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:RP5uK3PNbCaJZBS4IFuGCkMdqqk9606	intact-crc:9169F6C38CB4C370|rigid:kL/IRlnv36Uo32itFNCCtlmm8ig	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13322	uniprotkb:Q9UQB8-6	intact:EBI-80275|uniprotkb:O00427|uniprotkb:O00701|uniprotkb:O75222|uniprotkb:Q92606|uniprotkb:Q92907|uniprotkb:Q92948|intact:EBI-1760363|ensembl:ENSP00000381793|ensembl:ENSP00000385770|intact:EBI-1965437|uniprotkb:A7VJ95|uniprotkb:A4D258|uniprotkb:A8K0E6|uniprotkb:D3DVM9	intact:EBI-9092016	psi-mi:grb10_human(display_long)|uniprotkb:GRB10(gene name)|psi-mi:GRB10(display_short)|uniprotkb:GRBIR(gene name synonym)|uniprotkb:KIAA0207(gene name synonym)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Insulin receptor-binding protein Grb-IR(gene name synonym)	psi-mi:q9uqb8-6(display_long)|uniprotkb:Fas ligand-associated factor 3(gene name synonym)|uniprotkb:Insulin receptor substrate p53/p58(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:BAIAP2(gene name)|psi-mi:BAIAP2(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703601|imex:IM-22632-908	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904738"(vascular associated smooth muscle cell migration)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035036|interpro:IPR035037|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q13322|rcsb pdb:1NRV|rcsb pdb:3HK0|reactome:R-HSA-1433557|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-9607240|reactome:R-HSA-9648895|ensembl:ENSG00000106070(gene)|ensembl:ENST00000398812(transcript)|ensembl:ENST00000401949(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010467"(gene expression)|refseq:XP_011513606.1|refseq:XP_011513614.1|refseq:XP_011513618.1|refseq:NP_001001549.1|refseq:NP_001001550.1|refseq:NP_001001555.1|refseq:NP_005302.3|refseq:XP_016867534.1|refseq:XP_016867535.1|refseq:XP_016867552.1|refseq:XP_016867553.1|refseq:XP_016867554.1|refseq:XP_016867555.1|refseq:XP_016867556.1|refseq:XP_016867557.1|dip:DIP-31657N|refseq:NM_001001550.2(identity)|entrezgene/locuslink:2887(identity)	intact:EBI-525456(isoform-parent)|uniprotkb:Q9UQB8-6(isoform-parent)|refseq:XM_005256948.1(identity)|entrezgene/locuslink:10458(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:WBLkjS4iCC2gMTzR3izSFXGrBnk9606	rogid:n2iqdXaDCA6aLxGI9wl3/44N3ws9606	intact-crc:7FC822AA7CA16823|rigid:3PUW4d7N68dSWbKahl2aOtpiQZQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A6NJ69	uniprotkb:Q13387	intact:EBI-10692698|ensembl:ENSP00000327344	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	psi-mi:igip_human(display_long)|uniprotkb:IGIP(gene name)|psi-mi:IGIP(display_short)|uniprotkb:C5orf53(gene name synonym)	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703590|imex:IM-22632-907	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001007190.1|ensembl:ENSG00000182700(gene)|ensembl:ENST00000333305(transcript)|go:"GO:0005576"(extracellular region)|interpro:IPR038815|refseq:NM_001007189.1(identity)|entrezgene/locuslink:492311(identity)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:YMdw1Ve8L02Twy6Snv58/pCbOZ89606	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	intact-crc:D9804E6F9D42D22D|rigid:mAOa93YRsqU2y1G7FbqQSyz0Yec	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:Q13191	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-744027|uniprotkb:Q63Z43|uniprotkb:A8K9S7|uniprotkb:Q13192|uniprotkb:Q13193|uniprotkb:Q3LIC0|uniprotkb:Q8IVC5|uniprotkb:B7WNM4|intact:EBI-28969458|ensembl:ENSP00000377598|intact:EBI-8051403|intact:MINT-7907019	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:cblb_human(display_long)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703623|imex:IM-22632-910	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	refseq:NP_733762.2|refseq:NP_001308717.1|ensembl:ENSP00000377598|ensembl:ENST00000403724|ensembl:ENSP00000384816|ensembl:ENST00000405772|ensembl:ENSP00000384938|refseq:XP_011511559.1|ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q13191|rcsb pdb:2AK5|rcsb pdb:2BZ8|rcsb pdb:2DO6|rcsb pdb:2J6F|rcsb pdb:2JNH|rcsb pdb:2LDR|rcsb pdb:2OOA|rcsb pdb:2OOB|rcsb pdb:3PFV|rcsb pdb:3VGO|rcsb pdb:3ZNI|reactome:R-HSA-983168|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|dip:DIP-33091N|entrezgene/locuslink:868(identity)|refseq:NM_170662.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606	intact-crc:A3CB70318DC002B8|rigid:VCLmvgmS6GswxPilrRMAT3ZYrnE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:Q13308	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-2803245|uniprotkb:Q8NFA6|uniprotkb:Q5T650|uniprotkb:Q8NFA8|uniprotkb:Q13417|uniprotkb:Q6IQ54|uniprotkb:Q8NFA5|uniprotkb:Q8NFA7|uniprotkb:A8K974|uniprotkb:B7Z477|uniprotkb:E9PFZ5|ensembl:ENSP00000230419	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:ptk7_human(display_long)|uniprotkb:CCK4(gene name synonym)|uniprotkb:Colon carcinoma kinase 4(gene name synonym)|uniprotkb:Protein-tyrosine kinase 7(gene name synonym)|uniprotkb:PTK7(gene name)|psi-mi:PTK7(display_short)|uniprotkb:Pseudo tyrosine kinase receptor 7(gene name synonym)|uniprotkb:Tyrosine-protein kinase-like 7(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703612|imex:IM-22632-909	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	refseq:NP_001257327.1|refseq:NP_002812.2|refseq:NP_690619.1|refseq:NP_690620.1|refseq:NP_690621.1|ensembl:ENSG00000112655(gene)|ensembl:ENST00000230419(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001822"(kidney development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003401"(axis elongation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042060"(wound healing)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060026"(convergent extension)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q13308|rcsb pdb:6VG3|refseq:NM_152880.3(identity)|entrezgene/locuslink:5754(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:O4L3LFD0WvN1hDb1abqVBbW1gis9606	intact-crc:66A94C40EA6476DE|rigid:Ixtt55EkbO8g18bSBx8jEB3e930	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15117	uniprotkb:Q13094	intact:EBI-1753267|uniprotkb:O00359|ensembl:ENSP00000316460|ensembl:ENSP00000426346|uniprotkb:A8K2Y8|uniprotkb:E9PBV9|uniprotkb:Q9NZI9|uniprotkb:B4DLN2	intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794	psi-mi:fyb1_human(display_long)|uniprotkb:FYB1(gene name)|psi-mi:FYB1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLAP130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym)	psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703634|imex:IM-22632-911	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011512310.1|refseq:XP_011512311.1|refseq:XP_011512312.1|refseq:NP_955367.1|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|mint:O15117|rcsb pdb:1RI9|rcsb pdb:2GTJ|rcsb pdb:2GTO|reactome:R-HSA-202433|reactome:R-HSA-391160|ensembl:ENSG00000082074(gene)|ensembl:ENST00000351578(transcript)|ensembl:ENST00000515010(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|refseq:NP_001230022.1|refseq:NP_001456.3|refseq:XP_006714527.1|refseq:XP_006714528.1|refseq:XP_006714529.1|dip:DIP-42204N|entrezgene/locuslink:2533(identity)|refseq:NM_199335.3(identity)	refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|refseq:NM_005565.3(identity)|entrezgene/locuslink:3937(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), LCK (P06239), LYN (P07948), SRC (P12931), SYK (P43405), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ObeGCVefTolMBQGVT/WhglH5F009606	rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606	intact-crc:1CE21269227827DD|rigid:9rbdQztv+wREwsFELtQU6pI1u+E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14543	uniprotkb:Q13061-3	intact:EBI-714146|uniprotkb:O14509|ensembl:ENSP00000330341	intact:EBI-10695294|ensembl:ENSP00000437684	psi-mi:socs3_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 3(gene name synonym)|uniprotkb:SOCS3(gene name)|psi-mi:SOCS3(display_short)|uniprotkb:CIS3(gene name synonym)|uniprotkb:SSI3(gene name synonym)	psi-mi:q13061-3(display_long)|uniprotkb:TRDN(gene name)|psi-mi:TRDN(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703645|imex:IM-22632-912	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O14543|reactome:R-HSA-1059683|reactome:R-HSA-2586552|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8849474|reactome:R-HSA-8939242|reactome:R-HSA-8951664|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|go:"GO:0050728"(negative regulation of inflammatory response)|ensembl:ENSG00000184557(gene)|ensembl:ENST00000330871(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|refseq:NP_003946.3|entrezgene/locuslink:9021(identity)|refseq:NM_003955.4(identity)	intact:EBI-10757323(isoform-parent)|ensembl:ENSG00000186439(gene)|ensembl:ENST00000542443(transcript)|entrezgene/locuslink:10345(identity)|refseq:NM_001256022.1(identity)	-	-	isoform-comment:No experimental confirmation available.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8HnU9EL52BGdud2WFZwYsv5R22I9606	rogid:i4UiplUvJATqZ4qDj6kEPJeGc109606	intact-crc:AB675D34355F2D78|rigid:SmxEQrY/KkZMhokbVhvl+1+n8dE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12929	uniprotkb:P22681	intact:EBI-375576|uniprotkb:A6NMC3|ensembl:ENSP00000281172|ensembl:ENSP00000441867|ensembl:ENSP00000442388|ensembl:ENSP00000494689|ensembl:ENSP00000494842|ensembl:ENSP00000495722|ensembl:ENSP00000495824|ensembl:ENSP00000495956|ensembl:ENSP00000496406|ensembl:ENSP00000496516|uniprotkb:Q8N6J0|uniprotkb:B4DX66|uniprotkb:A8K6W2|uniprotkb:A8KA66	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:eps8_human(display_long)|uniprotkb:EPS8(gene name)|psi-mi:EPS8(display_short)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703656|imex:IM-22632-913	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000645775(transcript)|ensembl:ENST00000646828(transcript)|ensembl:ENSG00000151491(gene)|ensembl:ENST00000646918(transcript)|ensembl:ENST00000647087(transcript)|ensembl:ENST00000647224(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010458"(exit from mitosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0030426"(growth cone)|go:"GO:0030832"(regulation of actin filament length)|go:"GO:0031267"(small GTPase binding)|ensembl:ENST00000281172(transcript)|ensembl:ENST00000543523(transcript)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|ensembl:ENST00000543612(transcript)|ensembl:ENST00000642278(transcript)|ensembl:ENST00000644374(transcript)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030222|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q12929|rcsb pdb:2E8M|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_004438.3|dip:DIP-32859N|entrezgene/locuslink:2059(identity)|refseq:NM_004447.5(identity)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:ulBgb+4uZ7XrN4bLogRtd9I5AbY9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:681747552E4A76F1|rigid:MQJ654sQGRYXB5ENmRWtGAebZ3s	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q12841	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-2349801|uniprotkb:Q549Z0|uniprotkb:A8K523|uniprotkb:B4DTT5|uniprotkb:D3DN90|ensembl:ENSP00000295633	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:fstl1_human(display_long)|uniprotkb:FSTL1(gene name)|psi-mi:FSTL1(display_short)|uniprotkb:FRP(gene name synonym)|uniprotkb:Follistatin-like protein 1(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703667|imex:IM-22632-914	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_009016.1|ensembl:ENSG00000163430(gene)|ensembl:ENST00000295633(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0008201"(heparin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR036058|reactome:R-HSA-201451|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NM_007085.4(identity)|entrezgene/locuslink:11167(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FRK (P42685), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:2Y10WyTpml76Ksjw+X7dXUozFg09606	intact-crc:6E91FF950C431F5C|rigid:EdcF1/7vBJfy6RQf/6CaO51/xTg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08AM6	uniprotkb:P46108	intact:EBI-2107455|uniprotkb:Q13174|uniprotkb:Q6IA12|uniprotkb:Q7L4Y1|uniprotkb:Q9BW96|uniprotkb:Q9H6V6|uniprotkb:B3KPJ5|uniprotkb:B3KSM8|ensembl:ENSP00000261776	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:vac14_human(display_long)|uniprotkb:Tax1-binding protein 2(gene name synonym)|uniprotkb:VAC14(gene name)|psi-mi:VAC14(display_short)|uniprotkb:TAX1BP2(gene name synonym)|uniprotkb:TRX(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703678|imex:IM-22632-915	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060522.3|ensembl:ENSG00000103043(gene)|ensembl:ENST00000261776(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000306"(extrinsic component of vacuolar membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070772"(PAS complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021841|interpro:IPR026825|mint:Q08AM6|rcsb pdb:7K1Y|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|refseq:NM_018052.3(identity)|entrezgene/locuslink:55697(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:S9syIZ/DKHNbOM0Nw9oZP5F+AvA9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:EF96C10BC066B503|rigid:TloMdEDcCI9pVAMVpi8dcvxMDvM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07912	uniprotkb:Q8WXH5	intact:EBI-603457|intact:EBI-1384159|uniprotkb:Q6ZMQ0|uniprotkb:Q8N6U7|uniprotkb:Q96H59|ensembl:ENSP00000329425	intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522	psi-mi:ack1_human(display_long)|uniprotkb:ACK1(gene name synonym)|uniprotkb:TNK2(gene name)|psi-mi:TNK2(display_short)|uniprotkb:Tyrosine kinase non-receptor protein 2(gene name synonym)	psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703689|imex:IM-22632-916	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000329425|ensembl:ENST00000439230|ensembl:ENSP00000395588|ensembl:ENST00000671753|ensembl:ENSP00000499858|ensembl:ENSG00000061938(gene)|ensembl:ENST00000333602(transcript)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006897"(endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050699"(WW domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0097268"(cytoophidium)|go:"GO:0106310"(protein serine kinase activity)|refseq:NP_001010938.1|refseq:NP_005772.3|refseq:NP_001294975.1|dip:DIP-33858N|go:"GO:0106311"|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015116(GTPase binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR021619|interpro:IPR030220|interpro:IPR036028|interpro:IPR037085|mint:Q07912|rcsb pdb:1CF4|rcsb pdb:1U46|rcsb pdb:1U4D|rcsb pdb:1U54|rcsb pdb:3EQP|rcsb pdb:3EQR|rcsb pdb:4EWH|rcsb pdb:4HZR|rcsb pdb:4HZS|rcsb pdb:4ID7|rcsb pdb:5ZXB|rcsb pdb:6VQM|entrezgene/locuslink:10188(identity)|refseq:XM_006713468.1(identity)	refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N|entrezgene/locuslink:122809(identity)|refseq:NM_080867.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813), FRK (P42685), PTK2 (Q05397), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:AD7D+7w6zZOL3VHmf23YSk6NW2w9606	rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606	intact-crc:93F8BB86A3E521C6|rigid:uw0zJDIIJNyH7sH/ep1PzokcQX4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q07869	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-78615|uniprotkb:Q16241|uniprotkb:Q92486|uniprotkb:Q92689|uniprotkb:Q9Y3N1|ensembl:ENSP00000262735|ensembl:ENSP00000385246|ensembl:ENSP00000385523|uniprotkb:Q6I9S0|uniprotkb:B0G0X3	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:ppara_human(display_long)|uniprotkb:PPARA(gene name)|psi-mi:PPARA(display_short)|uniprotkb:NR1C1(gene name synonym)|uniprotkb:PPAR(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group C member 1(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703711|imex:IM-22632-918	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	refseq:XP_005261712.1|refseq:XP_005261713.1|ensembl:ENSG00000186951(gene)|ensembl:ENST00000262735(transcript)|ensembl:ENST00000402126(transcript)|ensembl:ENST00000407236(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008544"(epidermis development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010876"(lipid localization)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033993"(response to lipid)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070166"(enamel mineralization)|go:"GO:0045471"(response to ethanol)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|rcsb pdb:1I7G|go:"GO:0097371"(MDM2/MDM4 family protein binding)|rcsb pdb:1K7L|rcsb pdb:1KKQ|rcsb pdb:2NPA|rcsb pdb:2P54|rcsb pdb:2REW|rcsb pdb:2ZNN|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:2000191"(regulation of fatty acid transport)|go:"GO:2000272"(negative regulation of signaling receptor activity)|rcsb pdb:3ET1|rcsb pdb:3FEI|rcsb pdb:3G8I|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003074(Peroxisome proliferator-activated receptor)|interpro:IPR003076(Peroxisome proliferator-activated receptor, alpha)|rcsb pdb:3KDT|interpro:IPR013088(Zinc finger, NHR/GATA-type)|rcsb pdb:3KDU|interpro:IPR035500|mint:Q07869|rcsb pdb:3SP6|rcsb pdb:3VI8|rcsb pdb:4BCR|rcsb pdb:4CI4|reactome:R-HSA-1989781|rcsb pdb:5AZT|reactome:R-HSA-2151201|reactome:R-HSA-2426168|rcsb pdb:5HYK|rcsb pdb:6KAX|reactome:R-HSA-381340|rcsb pdb:6KAY|rcsb pdb:6KAZ|reactome:R-HSA-383280|rcsb pdb:6KB0|reactome:R-HSA-400206|rcsb pdb:6KB1|rcsb pdb:6KB2|rcsb pdb:6KB3|rcsb pdb:6KB4|rcsb pdb:6KB5|reactome:R-HSA-400253|reactome:R-HSA-4090294|rcsb pdb:6KB6|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:6KB7|rcsb pdb:6KB8|rcsb pdb:6KB9|rcsb pdb:6KBA|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6KYP|rcsb pdb:6L36|rcsb pdb:6L37|rcsb pdb:6L38|rcsb pdb:6L96|rcsb pdb:6LX4|rcsb pdb:6LX5|rcsb pdb:6LX6|rcsb pdb:6LX7|rcsb pdb:6LX8|rcsb pdb:6LX9|rcsb pdb:6LXA|rcsb pdb:6LXB|rcsb pdb:6LXC|rcsb pdb:7BPY|rcsb pdb:7BPZ|rcsb pdb:7BQ0|rcsb pdb:7BQ1|rcsb pdb:7BQ2|rcsb pdb:7BQ3|rcsb pdb:7BQ4|rcsb pdb:7C6Q|reactome:R-HSA-1368082|reactome:R-HSA-1368108|refseq:NP_001001928.1|refseq:NP_005027.2|refseq:XP_011528541.1|refseq:XP_011528542.1|refseq:XP_011528543.1|refseq:XP_011528544.1|refseq:XP_011528545.1|refseq:XP_006724332.1|refseq:XP_006724333.1|dip:DIP-241N|refseq:XM_006724271.1(identity)|entrezgene/locuslink:5465(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FRK (P42685), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:0ZZ5eL0cNC8OgOvd8spQ5ypBvAo9606	intact-crc:33B8D8705110D28A|rigid:zTvRdTBXirQk9l7jXtSGw+bNfpM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:Q07869	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-78615|uniprotkb:Q16241|uniprotkb:Q92486|uniprotkb:Q92689|uniprotkb:Q9Y3N1|ensembl:ENSP00000262735|ensembl:ENSP00000385246|ensembl:ENSP00000385523|uniprotkb:Q6I9S0|uniprotkb:B0G0X3	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:ppara_human(display_long)|uniprotkb:PPARA(gene name)|psi-mi:PPARA(display_short)|uniprotkb:NR1C1(gene name synonym)|uniprotkb:PPAR(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group C member 1(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703700|imex:IM-22632-917	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	refseq:XP_005261712.1|refseq:XP_005261713.1|ensembl:ENSG00000186951(gene)|ensembl:ENST00000262735(transcript)|ensembl:ENST00000402126(transcript)|ensembl:ENST00000407236(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008544"(epidermis development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010876"(lipid localization)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033993"(response to lipid)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070166"(enamel mineralization)|go:"GO:0045471"(response to ethanol)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|rcsb pdb:1I7G|go:"GO:0097371"(MDM2/MDM4 family protein binding)|rcsb pdb:1K7L|rcsb pdb:1KKQ|rcsb pdb:2NPA|rcsb pdb:2P54|rcsb pdb:2REW|rcsb pdb:2ZNN|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:2000191"(regulation of fatty acid transport)|go:"GO:2000272"(negative regulation of signaling receptor activity)|rcsb pdb:3ET1|rcsb pdb:3FEI|rcsb pdb:3G8I|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003074(Peroxisome proliferator-activated receptor)|interpro:IPR003076(Peroxisome proliferator-activated receptor, alpha)|rcsb pdb:3KDT|interpro:IPR013088(Zinc finger, NHR/GATA-type)|rcsb pdb:3KDU|interpro:IPR035500|mint:Q07869|rcsb pdb:3SP6|rcsb pdb:3VI8|rcsb pdb:4BCR|rcsb pdb:4CI4|reactome:R-HSA-1989781|rcsb pdb:5AZT|reactome:R-HSA-2151201|reactome:R-HSA-2426168|rcsb pdb:5HYK|rcsb pdb:6KAX|reactome:R-HSA-381340|rcsb pdb:6KAY|rcsb pdb:6KAZ|reactome:R-HSA-383280|rcsb pdb:6KB0|reactome:R-HSA-400206|rcsb pdb:6KB1|rcsb pdb:6KB2|rcsb pdb:6KB3|rcsb pdb:6KB4|rcsb pdb:6KB5|reactome:R-HSA-400253|reactome:R-HSA-4090294|rcsb pdb:6KB6|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:6KB7|rcsb pdb:6KB8|rcsb pdb:6KB9|rcsb pdb:6KBA|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6KYP|rcsb pdb:6L36|rcsb pdb:6L37|rcsb pdb:6L38|rcsb pdb:6L96|rcsb pdb:6LX4|rcsb pdb:6LX5|rcsb pdb:6LX6|rcsb pdb:6LX7|rcsb pdb:6LX8|rcsb pdb:6LX9|rcsb pdb:6LXA|rcsb pdb:6LXB|rcsb pdb:6LXC|rcsb pdb:7BPY|rcsb pdb:7BPZ|rcsb pdb:7BQ0|rcsb pdb:7BQ1|rcsb pdb:7BQ2|rcsb pdb:7BQ3|rcsb pdb:7BQ4|rcsb pdb:7C6Q|reactome:R-HSA-1368082|reactome:R-HSA-1368108|refseq:NP_001001928.1|refseq:NP_005027.2|refseq:XP_011528541.1|refseq:XP_011528542.1|refseq:XP_011528543.1|refseq:XP_011528544.1|refseq:XP_011528545.1|refseq:XP_006724332.1|refseq:XP_006724333.1|dip:DIP-241N|refseq:XM_006724271.1(identity)|entrezgene/locuslink:5465(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FER (P16591), FGR (P09769), FRK (P42685), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:0ZZ5eL0cNC8OgOvd8spQ5ypBvAo9606	intact-crc:C0BF1E8812B2125B|rigid:qNWT3WTApUjeir+Fgq3I8E/dEac	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14451	uniprotkb:Q05397	intact:EBI-970191|ensembl:ENSP00000310771|ensembl:ENSP00000377759|ensembl:ENSP00000377761|uniprotkb:B2RAV1|uniprotkb:B3KNL0|uniprotkb:B3KWP9|uniprotkb:B7WP75|uniprotkb:Q53YD3|uniprotkb:Q9Y220|uniprotkb:Q92568|uniprotkb:Q96DF9|intact:EBI-1257061|uniprotkb:J3KQM4	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:grb7_human(display_long)|uniprotkb:GRB7(gene name)|psi-mi:GRB7(display_short)|uniprotkb:GRB7 adapter protein(gene name synonym)|uniprotkb:Epidermal growth factor receptor GRB-7(gene name synonym)|uniprotkb:B47(gene name synonym)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703733|imex:IM-22632-920	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141738(gene)|ensembl:ENST00000309156(transcript)|ensembl:ENST00000394209(transcript)|ensembl:ENST00000394211(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042995"(cell projection)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035032|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q14451|rcsb pdb:1MW4|rcsb pdb:1WGR|rcsb pdb:2L4K|rcsb pdb:2QMS|rcsb pdb:3PQZ|rcsb pdb:4WWQ|rcsb pdb:4X6S|rcsb pdb:5D0J|rcsb pdb:5EEL|rcsb pdb:5EEQ|rcsb pdb:5TYI|rcsb pdb:5U06|rcsb pdb:5U1Q|go:"GO:0042802"(identical protein binding)|reactome:R-HSA-1306955|reactome:R-HSA-186763|reactome:R-HSA-210993|reactome:R-HSA-8853659|reactome:R-HSA-9696273|reactome:R-HSA-1433557|refseq:NP_001025173.1|refseq:NP_001229371.1|refseq:NP_001229372.1|refseq:NP_005301.2|refseq:NP_001317136.1|dip:DIP-502N|entrezgene/locuslink:2886(identity)|refseq:NM_001030002.2(identity)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:XViWZjk5YwdZFTG3zs2aNdxeFVQ9606	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	intact-crc:3A82F0EE25972612|rigid:nJTODhiyHVFKZAo2ndT6Ea3Yjsg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TBB1	uniprotkb:Q06124-3	intact:EBI-739832|uniprotkb:Q4W5K7|uniprotkb:Q8N4C2|uniprotkb:Q96MJ7|uniprotkb:Q9BY20|ensembl:ENSP00000263925	intact:EBI-10694227|ensembl:ENSP00000376376	psi-mi:lnx1_human(display_long)|uniprotkb:LNX1(gene name)|psi-mi:LNX1(display_short)|uniprotkb:LNX(gene name synonym)|uniprotkb:Numb-binding protein 1(gene name synonym)|uniprotkb:Ligand of Numb-protein X 1(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 2(gene name synonym)|uniprotkb:PDZRN2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase LNX(gene name synonym)|uniprotkb:UNQ574/PRO1136(orf name)	psi-mi:q06124-3(display_long)|uniprotkb:PTPN11(gene name)|psi-mi:PTPN11(display_short)|uniprotkb:PTP2C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1D(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 2C(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)|uniprotkb:SH-PTP3(gene name synonym)|uniprotkb:SHPTP2(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703722|imex:IM-22632-919	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119800.1|refseq:NP_116011.2|refseq:XP_005265842.1|refseq:XP_016864265.1|ensembl:ENSG00000072201(gene)|ensembl:ENST00000263925(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8TBB1|rcsb pdb:3B76|rcsb pdb:5H7R|rcsb pdb:5H7S|reactome:R-HSA-983168|refseq:NM_001126328.2(identity)|entrezgene/locuslink:84708(identity)	ensembl:ENSG00000179295(gene)|ensembl:ENST00000392597(transcript)|intact:EBI-297779(isoform-parent)|entrezgene/locuslink:5781(identity)|refseq:NM_080601.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FES (P07332), FRK (P42685), PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:tWvePnVxh9yxWl8nQd3KZhCSKKo9606	rogid:yxq9b69NsSDmdOoSrvXwZXpwK+U9606	intact-crc:74D3365E3783C757|rigid:2SXR0hk91Uj+ezVNLaAt51ca0+4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TEW6	uniprotkb:Q05397	intact:EBI-6918542|ensembl:ENSP00000344277|ensembl:ENSP00000455128|uniprotkb:O75209|uniprotkb:Q9BTP2|uniprotkb:Q9NVV3	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:dok4_human(display_long)|uniprotkb:DOK4(gene name)|psi-mi:DOK4(display_short)|uniprotkb:Downstream of tyrosine kinase 4(gene name synonym)|uniprotkb:Insulin receptor substrate 5(gene name synonym)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703744|imex:IM-22632-921	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000125170(gene)|ensembl:ENST00000340099(transcript)|ensembl:ENST00000569548(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0043410"(positive regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_060580.2|refseq:XP_005256100.1|entrezgene/locuslink:55715(identity)|refseq:NM_018110.3(identity)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BLK (P51451), FGR (P09769), FYN (P06241), HCK (P08631), SRC (P12931), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Xc4aPsHtdQKj02Q5cqqgw29pSS09606	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	intact-crc:D56AD915C9A73696|rigid:rpYgJWuUtBjgIn3JYqmPeoTJYv0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05397	uniprotkb:P46108	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703755|imex:IM-22632-922	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:9FBAFD8EF89C0756|rigid:CTv6TM/tNrVySirPOGGTdlAhD7I	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A1A4S6	uniprotkb:P78314	intact:EBI-1390944|uniprotkb:Q2VPC4|uniprotkb:Q2VPC5|uniprotkb:Q96EV3|uniprotkb:Q96S75|uniprotkb:A1L0S5|ensembl:ENSP00000336923	intact:EBI-727062|uniprotkb:O00500|uniprotkb:O15373|uniprotkb:P78315|uniprotkb:A6NNC2|uniprotkb:B2R5R6|uniprotkb:B4DT04|uniprotkb:D3DVR0|intact:EBI-28985856|ensembl:ENSP00000348685|ensembl:ENSP00000422168|uniprotkb:D6R919	psi-mi:rhg10_human(display_long)|uniprotkb:ARHGAP10(gene name)|psi-mi:ARHGAP10(display_short)|uniprotkb:GRAF2(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 10(gene name synonym)|uniprotkb:GTPase regulator associated with focal adhesion kinase 2(gene name synonym)|uniprotkb:Graf-related protein 2(gene name synonym)	psi-mi:3bp2_human(display_long)|uniprotkb:SH3BP2(gene name)|psi-mi:SH3BP2(display_short)|uniprotkb:3BP2(gene name synonym)|uniprotkb:RES4-23(orf name)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703766|imex:IM-22632-923	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078881.3|ensembl:ENSG00000071205(gene)|ensembl:ENST00000336498(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|interpro:IPR035485|interpro:IPR035486|interpro:IPR036028|rcsb pdb:2MIO|reactome:R-HSA-211728|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|refseq:XM_005263216.2(identity)|entrezgene/locuslink:79658(identity)	refseq:NP_001116153.1|refseq:NP_001139327.1|refseq:NP_001139328.1|refseq:NP_003014.3|ensembl:ENSP00000348685|ensembl:ENST00000435136|ensembl:ENSP00000403231|ensembl:ENSP00000422168|ensembl:ENST00000511747|ensembl:ENSP00000424846|ensembl:ENST00000513020|ensembl:ENSP00000424072|ensembl:ENST00000515737|ensembl:ENSP00000422605|ensembl:ENSG00000087266(gene)|ensembl:ENST00000356331(transcript)|ensembl:ENST00000503393(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035847|interpro:IPR035848|interpro:IPR036860|mint:P78314|rcsb pdb:2CR4|rcsb pdb:3TWR|entrezgene/locuslink:6452(identity)|refseq:NM_001122681.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:gbHj2b+qPHC9tKs3Y3eRicrt8mk9606	rogid:W+/geQfSvLlQA6UvDPYN4zQCzh89606	intact-crc:3363E09DDE248903|rigid:6M7eC07h8InIpcSbnfd66/ciGbg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:P68402	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-713724|uniprotkb:A8DPS6|uniprotkb:Q6IBR6|uniprotkb:O00687|uniprotkb:Q29459|ensembl:ENSP00000435289|uniprotkb:A8DPS5|uniprotkb:E9PEJ5|uniprotkb:A8DPS7|uniprotkb:E9PLP3	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:pa1b2_human(display_long)|uniprotkb:PAF acetylhydrolase 30 kDa subunit(gene name synonym)|uniprotkb:PAF-AH subunit beta(gene name synonym)|uniprotkb:PAFAH1B2(gene name)|psi-mi:PAFAH1B2(display_short)|uniprotkb:PAFAHB(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703777|imex:IM-22632-924	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	ensembl:ENSG00000168092(gene)|ensembl:ENST00000527958(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003847"(1-alkyl-2-acetylglycerophosphocholine esterase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008247"(1-alkyl-2-acetylglycerophosphocholine esterase complex)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047179"(platelet-activating factor acetyltransferase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR013830(Esterase, SGNH hydrolase-type)|interpro:IPR036514|rcsb pdb:1VYH|reactome:R-HSA-6798695|reactome:R-HSA-6811436|refseq:NP_001296360.1|refseq:NP_001171677.1|refseq:NP_002563.1|refseq:NP_001171676.1|refseq:NP_001171675.1|refseq:NM_002572.3(identity)|entrezgene/locuslink:5049(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:lor3gsaIQ071mc4l0OfQelfuQdg9606	intact-crc:DF7B77455581F23B|rigid:02oJ9eRitewDt/DBR831ItK6uy8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q96SW2-2	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-10693561|ensembl:ENSP00000412499	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703799|imex:IM-22632-926	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent)|entrezgene/locuslink:51185(identity)|refseq:NM_001173482.1(identity)	-	-	isoform-comment:No experimental confirmation available.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606	intact-crc:F89DF95BDAC34521|rigid:ZLYqR1/+rZr+6SJqPfvGS0ONSuI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q5SXH7	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-10691507|uniprotkb:Q6ZQR5|uniprotkb:Q9H5D9|uniprotkb:Q5SXH8|uniprotkb:Q8NE42|uniprotkb:Q5SXI0|uniprotkb:B3KX00|uniprotkb:B6EDE1|uniprotkb:A8KA02|ensembl:ENSP00000354332|ensembl:ENSP00000358316|ensembl:ENSP00000358318|ensembl:ENSP00000483759	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:pkhs1_human(display_long)|uniprotkb:PLEKHS1(gene name)|psi-mi:PLEKHS1(display_short)|uniprotkb:C10orf81(gene name synonym)|uniprotkb:Epididymis luminal protein 185(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703788|imex:IM-22632-925	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	refseq:NP_001180363.1|refseq:NP_001180364.1|refseq:NP_079165.3|refseq:NP_872407.1|ensembl:ENSG00000148735(gene)|ensembl:ENST00000361048(transcript)|ensembl:ENST00000369310(transcript)|ensembl:ENST00000369312(transcript)|ensembl:ENST00000619563(transcript)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR042986|entrezgene/locuslink:79949(identity)|refseq:XM_005270162.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), SRC (P12931), SYK (P43405), TNK1 (Q13470), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2020/10/22	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:yEOMXxncrrBHP8H39uEfgZG1c4E9606	intact-crc:6DB4F7A7C843909C|rigid:6ePB9aiHYPGZzAy2+JxOAss/NSc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BRT2	uniprotkb:P62993	intact:EBI-1054584|uniprotkb:B2R4I0|ensembl:ENSP00000476140	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:uqcc2_human(display_long)|uniprotkb:UQCC2(gene name)|psi-mi:UQCC2(display_short)|uniprotkb:Breast cancer-associated protein SGA-81M(gene name synonym)|uniprotkb:C6orf125(gene name synonym)|uniprotkb:MNF1(gene name synonym)|uniprotkb:Mitochondrial nucleoid factor 1(gene name synonym)|uniprotkb:Mitochondrial protein M19(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703810|imex:IM-22632-927	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115716.1|ensembl:ENSG00000137288(gene)|ensembl:ENST00000607484(transcript)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR037698|entrezgene/locuslink:84300(identity)|refseq:NM_032340.3(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:5bqVcfnTXOCOuCVCrEtzEaChT3Y9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:3FC59DCEA00335C5|rigid:WV8/wchdUti/YCAlWh3J4wStMsU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H7T9	uniprotkb:P62993	intact:EBI-10693257|uniprotkb:C9EI59|uniprotkb:Q53F70|ensembl:ENSP00000363416	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:aunip_human(display_long)|uniprotkb:AUNIP(gene name)|psi-mi:AUNIP(display_short)|uniprotkb:C1orf135(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703821|imex:IM-22632-928	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001274419.1|refseq:NP_076942.1|ensembl:ENSG00000127423(gene)|ensembl:ENST00000374298(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000922"(spindle pole)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0090734"(site of DNA damage)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR029286|entrezgene/locuslink:79000(identity)|refseq:NM_024037.2(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:z7isXKkndjeP4zxnq0kVAW+ZmRo9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:4FF6C5ED40106082|rigid:XGPbrBfaF95RtBoZE5bJbxTQLZk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15027	uniprotkb:P62993	intact:EBI-751746|uniprotkb:Q53XN9|ensembl:ENSP00000158762|ensembl:ENSP00000499859	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:acap1_human(display_long)|uniprotkb:ACAP1(gene name)|psi-mi:ACAP1(display_short)|uniprotkb:Centaurin-beta-1(gene name synonym)|uniprotkb:CENTB1(gene name synonym)|uniprotkb:KIAA0050(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703832|imex:IM-22632-929	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055531.1|interpro:IPR038508|mint:Q15027|rcsb pdb:3JUE|rcsb pdb:3T9K|rcsb pdb:4CKG|rcsb pdb:4CKH|rcsb pdb:4F1P|rcsb pdb:4NSW|rcsb pdb:5H3D|ensembl:ENSG00000072818(gene)|ensembl:ENSG00000288169(gene)|ensembl:ENST00000158762(transcript)|ensembl:ENST00000672212(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR036770|interpro:IPR037278|entrezgene/locuslink:9744(identity)|refseq:NM_014716.3(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), SYK (P43405)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:pdHptA2uWwLfGAtHieVj+hm1udw9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:1FFC2B4FE55C61DD|rigid:vZECfRDHzgIs5K2hwUmaNW9QQLU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96ID7	uniprotkb:P62993	intact:EBI-10693700|intact:EBI-12932467	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:q96id7_human(display_long)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703843|imex:IM-22632-930	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	entrezgene/locuslink:1870(identity)|refseq:NM_004091.3(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:JdiIb6xsGAVQW//ms2Dj9fdTz+U9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:4E58F1BF6E179197|rigid:YUYpSDXflb23KSQhz+6pKdugDVk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16643	uniprotkb:P62993	intact:EBI-351394|uniprotkb:Q9UFZ5|uniprotkb:B2RBG0|ensembl:ENSP00000308532|intact:EBI-4404710|uniprotkb:A8MV58	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:dreb_human(display_long)|uniprotkb:DBN1(gene name)|psi-mi:DBN1(display_short)|uniprotkb:Developmentally-regulated brain protein(gene name synonym)|uniprotkb:D0S117E(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703854|imex:IM-22632-931	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004386.2|refseq:NP_543157.1|refseq:XP_005265884.1|ensembl:ENSG00000113758(gene)|ensembl:ENST00000309007(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0042641"(actomyosin)|go:"GO:0030425"(dendrite)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051015"(actin filament binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028438|interpro:IPR029006|mint:Q16643|go:"GO:0030426"(growth cone)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031915"(positive regulation of synaptic plasticity)|rcsb pdb:5Y1Z|rcsb pdb:5ZZ9|reactome:R-HSA-9013405|reactome:R-HSA-9013407|reactome:R-HSA-9013418|reactome:R-HSA-9013422|go:"GO:0032507"(maintenance of protein location in cell)|refseq:XP_016864629.1|refseq:NM_004395.3(identity)|entrezgene/locuslink:1627(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:0+VPJM5mTuG2jzmzGG3iLswmCUc9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:9A8102CA931CFAB1|rigid:bK7RLAO4Bt4GqOKnUzGxYpPX+AE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P55072	uniprotkb:P62993	intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703865|imex:IM-22632-932	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N|refseq:NM_007126.3(identity)|entrezgene/locuslink:7415(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), SRC (P12931), SYK (P43405), TNK1 (Q13470), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:6497FA940DA14AE4|rigid:p/r1PEfHpVYXmq6Zo4T+A4jzgGQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P55072	uniprotkb:Q92569	intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703876|imex:IM-22632-933	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N|refseq:NM_007126.3(identity)|entrezgene/locuslink:7415(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:2F0971556B67278A|rigid:vZJtzodDGZ4WZVMc7/P0Xy4rXag	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TEW6	uniprotkb:P52630	intact:EBI-6918542|ensembl:ENSP00000344277|ensembl:ENSP00000455128|uniprotkb:O75209|uniprotkb:Q9BTP2|uniprotkb:Q9NVV3	intact:EBI-1546963|uniprotkb:Q16430|uniprotkb:Q16431|uniprotkb:Q9UDL4|intact:EBI-10989287|uniprotkb:B4DLC7|uniprotkb:G3V2M6|ensembl:ENSP00000315768	psi-mi:dok4_human(display_long)|uniprotkb:DOK4(gene name)|psi-mi:DOK4(display_short)|uniprotkb:Downstream of tyrosine kinase 4(gene name synonym)|uniprotkb:Insulin receptor substrate 5(gene name synonym)	psi-mi:stat2_human(display_long)|uniprotkb:p113(gene name synonym)|uniprotkb:STAT2(gene name)|psi-mi:STAT2(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703887|imex:IM-22632-934	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000125170(gene)|ensembl:ENST00000340099(transcript)|ensembl:ENST00000569548(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0043410"(positive regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_060580.2|refseq:XP_005256100.1|entrezgene/locuslink:55715(identity)|refseq:NM_018110.3(identity)	refseq:NP_005410.1|refseq:NP_938146.1|dip:DIP-38511N|ensembl:ENSG00000170581(gene)|ensembl:ENST00000314128(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0090140"(regulation of mitochondrial fission)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860|mint:P52630|rcsb pdb:2KA4|rcsb pdb:6UX2|rcsb pdb:6WCZ|reactome:R-HSA-8854691|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9679191|entrezgene/locuslink:6773(identity)|refseq:NM_005419.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Xc4aPsHtdQKj02Q5cqqgw29pSS09606	rogid:uA0lxm5vmrLClQRP7NItd0/u4Ko9606	intact-crc:5DE81FBA95200AB6|rigid:ygzwDYw72Kzyg+RFyCEBurCIvls	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49757	uniprotkb:P35568	intact:EBI-915016|uniprotkb:Q6NUQ7|uniprotkb:Q86SY1|uniprotkb:Q8WW73|uniprotkb:Q9UBG1|uniprotkb:Q9UEQ4|uniprotkb:Q9UKE8|uniprotkb:Q9UKE9|uniprotkb:Q9UKF0|uniprotkb:Q9UQJ4|uniprotkb:B4E2B1|uniprotkb:B1P2N7|uniprotkb:B1P2N8|uniprotkb:B1P2N9|uniprotkb:B1P2N5|uniprotkb:B1P2N6|intact:EBI-28966915|ensembl:ENSP00000347169|ensembl:ENSP00000451300	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	psi-mi:numb_human(display_long)|uniprotkb:Protein S171(gene name synonym)|uniprotkb:NUMB(gene name)|psi-mi:NUMB(display_short)|uniprotkb:C14orf41(gene name synonym)	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703909|imex:IM-22632-936	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000554521|ensembl:ENSP00000450817|ensembl:ENST00000554546|ensembl:ENSP00000452416|ensembl:ENSP00000451300|ensembl:ENST00000555394|ensembl:ENSP00000451625|ensembl:ENST00000555738|ensembl:ENSP00000452069|ensembl:ENST00000557597|ensembl:ENSP00000451117|ensembl:ENST00000559312|ensembl:ENSP00000452888|ensembl:ENST00000560335|ensembl:ENSP00000453209|ensembl:ENSP00000347169|ensembl:ENST00000356296|ensembl:ENSP00000348644|ensembl:ENST00000359560|ensembl:ENSP00000352563|ensembl:ENST00000535282|ensembl:ENSP00000441258|ensembl:ENST00000544991|ensembl:ENSP00000446001|refseq:NP_001307043.1|refseq:NP_001005743.1|refseq:NP_001005744.1|refseq:NP_001005745.1|refseq:NP_003735.3|dip:DIP-37981N|ensembl:ENSG00000133961(gene)|ensembl:ENST00000355058(transcript)|ensembl:ENST00000555238(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021849"(neuroblast division in subventricular zone)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0034332"(adherens junction organization)|go:"GO:0045177"(apical part of cell)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)|mint:P49757|rcsb pdb:5NJJ|rcsb pdb:5NJK|reactome:R-HSA-2122948|reactome:R-HSA-437239|reactome:R-HSA-5610780|reactome:R-HSA-5632684|entrezgene/locuslink:8650(identity)|refseq:XM_006720296.1(identity)	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772|refseq:NM_005544.2(identity)|entrezgene/locuslink:3667(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FRK (P42685), FYN (P06241), HCK (P08631), PTK2 (Q05397), SRC (P12931), TNK1 (Q13470), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:X+CHBhp67o6ROnf86RCtXlCAaF49606	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	intact-crc:9FF3B74B6B8105B2|rigid:gEzyvtKT7PblhpFKAcc2sN2Vmls	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50552	uniprotkb:O43559	intact:EBI-748201|uniprotkb:Q6PIZ1|uniprotkb:Q93035|uniprotkb:B2RBT9|intact:EBI-28992147|ensembl:ENSP00000245932	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	psi-mi:vasp_human(display_long)|uniprotkb:VASP(gene name)|psi-mi:VASP(display_short)	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703898|imex:IM-22632-935	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003361.1|ensembl:ENSP00000245932|ensembl:ENSG00000125753(gene)|ensembl:ENST00000245932(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014885(VASP tetramerisation)|interpro:IPR017354(Vasodilator-stimulated phosphoprotein)|interpro:IPR034367|interpro:IPR038023|mint:P50552|rcsb pdb:1EGX|rcsb pdb:1JNG|rcsb pdb:1USD|rcsb pdb:1USE|rcsb pdb:2PAV|rcsb pdb:2PBD|rcsb pdb:3CHW|reactome:R-HSA-202433|reactome:R-HSA-376176|reactome:R-HSA-446353|dip:DIP-44105N|refseq:XM_005259199.1(identity)|entrezgene/locuslink:7408(identity)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:G8ONp2lhbQKUCrDKnx8AMIKSNHA9606	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	intact-crc:9760C1F917F8A0DF|rigid:dD5sMtZ7vD/wK+/TA72WjCtkA+I	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43559	uniprotkb:P49757	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	intact:EBI-915016|uniprotkb:Q6NUQ7|uniprotkb:Q86SY1|uniprotkb:Q8WW73|uniprotkb:Q9UBG1|uniprotkb:Q9UEQ4|uniprotkb:Q9UKE8|uniprotkb:Q9UKE9|uniprotkb:Q9UKF0|uniprotkb:Q9UQJ4|uniprotkb:B4E2B1|uniprotkb:B1P2N7|uniprotkb:B1P2N8|uniprotkb:B1P2N9|uniprotkb:B1P2N5|uniprotkb:B1P2N6|intact:EBI-28966915|ensembl:ENSP00000347169|ensembl:ENSP00000451300	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:numb_human(display_long)|uniprotkb:Protein S171(gene name synonym)|uniprotkb:NUMB(gene name)|psi-mi:NUMB(display_short)|uniprotkb:C14orf41(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703920|imex:IM-22632-937	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	ensembl:ENST00000554521|ensembl:ENSP00000450817|ensembl:ENST00000554546|ensembl:ENSP00000452416|ensembl:ENSP00000451300|ensembl:ENST00000555394|ensembl:ENSP00000451625|ensembl:ENST00000555738|ensembl:ENSP00000452069|ensembl:ENST00000557597|ensembl:ENSP00000451117|ensembl:ENST00000559312|ensembl:ENSP00000452888|ensembl:ENST00000560335|ensembl:ENSP00000453209|ensembl:ENSP00000347169|ensembl:ENST00000356296|ensembl:ENSP00000348644|ensembl:ENST00000359560|ensembl:ENSP00000352563|ensembl:ENST00000535282|ensembl:ENSP00000441258|ensembl:ENST00000544991|ensembl:ENSP00000446001|refseq:NP_001307043.1|refseq:NP_001005743.1|refseq:NP_001005744.1|refseq:NP_001005745.1|refseq:NP_003735.3|dip:DIP-37981N|ensembl:ENSG00000133961(gene)|ensembl:ENST00000355058(transcript)|ensembl:ENST00000555238(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021849"(neuroblast division in subventricular zone)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0034332"(adherens junction organization)|go:"GO:0045177"(apical part of cell)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)|mint:P49757|rcsb pdb:5NJJ|rcsb pdb:5NJK|reactome:R-HSA-2122948|reactome:R-HSA-437239|reactome:R-HSA-5610780|reactome:R-HSA-5632684|entrezgene/locuslink:8650(identity)|refseq:XM_006720296.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	rogid:X+CHBhp67o6ROnf86RCtXlCAaF49606	intact-crc:C61A0935CDFEF3B0|rigid:/rYK0DK3uDFykUS3VLBPKpfrE8c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13191	uniprotkb:P46109	intact:EBI-744027|uniprotkb:Q63Z43|uniprotkb:A8K9S7|uniprotkb:Q13192|uniprotkb:Q13193|uniprotkb:Q3LIC0|uniprotkb:Q8IVC5|uniprotkb:B7WNM4|intact:EBI-28969458|ensembl:ENSP00000377598|intact:EBI-8051403|intact:MINT-7907019	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	psi-mi:cblb_human(display_long)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703931|imex:IM-22632-938	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_733762.2|refseq:NP_001308717.1|ensembl:ENSP00000377598|ensembl:ENST00000403724|ensembl:ENSP00000384816|ensembl:ENST00000405772|ensembl:ENSP00000384938|refseq:XP_011511559.1|ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q13191|rcsb pdb:2AK5|rcsb pdb:2BZ8|rcsb pdb:2DO6|rcsb pdb:2J6F|rcsb pdb:2JNH|rcsb pdb:2LDR|rcsb pdb:2OOA|rcsb pdb:2OOB|rcsb pdb:3PFV|rcsb pdb:3VGO|rcsb pdb:3ZNI|reactome:R-HSA-983168|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|dip:DIP-33091N|entrezgene/locuslink:868(identity)|refseq:NM_170662.3(identity)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|entrezgene/locuslink:1399(identity)|refseq:NM_005207.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	intact-crc:F60B5AD69906E267|rigid:rbINobWATHyE+GffskCPt+EsR0M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:P46108-2	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703942|imex:IM-22632-939	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:7D402DE189DC8E3B|rigid:tIx6Pb3N2s7eIFyFZyObLM7+nxI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13191	uniprotkb:P46108-2	intact:EBI-744027|uniprotkb:Q63Z43|uniprotkb:A8K9S7|uniprotkb:Q13192|uniprotkb:Q13193|uniprotkb:Q3LIC0|uniprotkb:Q8IVC5|uniprotkb:B7WNM4|intact:EBI-28969458|ensembl:ENSP00000377598|intact:EBI-8051403|intact:MINT-7907019	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:cblb_human(display_long)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703953|imex:IM-22632-940	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_733762.2|refseq:NP_001308717.1|ensembl:ENSP00000377598|ensembl:ENST00000403724|ensembl:ENSP00000384816|ensembl:ENST00000405772|ensembl:ENSP00000384938|refseq:XP_011511559.1|ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q13191|rcsb pdb:2AK5|rcsb pdb:2BZ8|rcsb pdb:2DO6|rcsb pdb:2J6F|rcsb pdb:2JNH|rcsb pdb:2LDR|rcsb pdb:2OOA|rcsb pdb:2OOB|rcsb pdb:3PFV|rcsb pdb:3VGO|rcsb pdb:3ZNI|reactome:R-HSA-983168|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|dip:DIP-33091N|entrezgene/locuslink:868(identity)|refseq:NM_170662.3(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:3A1458D575301521|rigid:pUc8+3qlF688qmvoNaB+aV3QeQY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WVB6	uniprotkb:P46108-2	intact:EBI-1237523|uniprotkb:Q7Z6Y6|uniprotkb:Q9BR83|uniprotkb:Q9BRG5|uniprotkb:Q9H7K3|uniprotkb:B7ZBA2|uniprotkb:Q7Z6Y4|uniprotkb:D3DU68|intact:EBI-28984493|ensembl:ENSP00000262315	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:ctf18_human(display_long)|uniprotkb:CHTF18(gene name)|psi-mi:CHTF18(display_short)|uniprotkb:CTF18(gene name synonym)|uniprotkb:C16orf41(gene name synonym)|uniprotkb:CHL12(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703964|imex:IM-22632-941	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071375.1|refseq:XP_011520875.1|ensembl:ENSP00000262315|ensembl:ENST00000455171|ensembl:ENSP00000406252|refseq:XP_005255528.1|ensembl:ENSG00000127586(gene)|ensembl:ENST00000262315(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0031390"(Ctf18 RFC-like complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR027417|mint:Q8WVB6|reactome:R-HSA-174411|entrezgene/locuslink:63922(identity)|refseq:NM_022092.2(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:cIuesMN9KfDCiavKy3XvnYV+IA09606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:43D1B161BB09AF2D|rigid:2J+G50/HDukuFTN8BPmBZBdBhg0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96KP4	uniprotkb:P46108-2	intact:EBI-1190734|uniprotkb:Q9BQ94|uniprotkb:Q9NVB4|uniprotkb:Q8WY59|uniprotkb:B3KUG4|uniprotkb:V9HWE5|ensembl:ENSP00000325548|ensembl:ENSP00000462311	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:cndp2_human(display_long)|uniprotkb:CNDP dipeptidase 2(gene name synonym)|uniprotkb:Glutamate carboxypeptidase-like protein 1(gene name synonym)|uniprotkb:Peptidase A(gene name synonym)|uniprotkb:HEL-S-13(gene name synonym)|uniprotkb:CNDP2(gene name)|psi-mi:CNDP2(display_short)|uniprotkb:CN2(gene name synonym)|uniprotkb:CPGL(gene name synonym)|uniprotkb:PEPA(gene name synonym)|uniprotkb:Threonyl dipeptidase(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703975|imex:IM-22632-942	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161971.1|refseq:NP_060705.2|refseq:XP_005266785.1|refseq:XP_006722566.1|refseq:XP_011524373.1|refseq:XP_011524374.1|ensembl:ENSG00000133313(gene)|ensembl:ENST00000324262(transcript)|ensembl:ENST00000579847(transcript)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0016805"(dipeptidase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070573"(metallodipeptidase activity)|go:"GO:0103046"(alanylglutamate dipeptidase activity)|interpro:IPR001261(ArgE/DapE/ACY1/CPG2/YscS, conserved site)|interpro:IPR002933(Peptidase M20)|interpro:IPR011650(Peptidase M20, dimerisation)|interpro:IPR017153(Glutathione degradosome, DUG1)|rcsb pdb:4RUH|reactome:R-HSA-174403|refseq:NM_018235.2(identity)|entrezgene/locuslink:55748(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:qAepmR2WYMtTL3WyP7AZz39LhkM9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:00136621ABC90C48|rigid:VlC9RUy90c3yjJE8KED9AlFJ/jc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:Q5H9J7	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-10243741|uniprotkb:Q56A74|uniprotkb:Q569J0|ensembl:ENSP00000328030|ensembl:ENSP00000446054	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:bex5_human(display_long)|uniprotkb:BEX5(gene name)|psi-mi:BEX5(display_short)|uniprotkb:Brain-expressed X-linked protein 5(gene name synonym)|uniprotkb:NADE2(gene name synonym)|uniprotkb:NGFRAP1-like protein 1(gene name synonym)|uniprotkb:NGFRAP1L1(gene name synonym)|uniprotkb:Nerve growth factor receptor-associated protein 2(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703986|imex:IM-22632-943	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_001012996.1|refseq:NP_001153032.1|ensembl:ENSG00000184515(gene)|ensembl:ENST00000333643(transcript)|ensembl:ENST00000543160(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR007623(Brain expressed X-linked like protein)|interpro:IPR021156|refseq:NM_001012978.2(identity)|entrezgene/locuslink:340542(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:Yx5JQ84k1eJVM/Sc9wQX/OMgtRI9606	intact-crc:0B4CF3595F59BEF6|rigid:WeRQAzn23EP1kZp67ifPnHbI7bQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9ULV8	uniprotkb:P46108-2	intact:EBI-2341018|uniprotkb:Q9Y5Z3|uniprotkb:Q8N1E5|uniprotkb:Q9Y5Z2|intact:EBI-28975910|ensembl:ENSP00000494162	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:cblc_human(display_long)|uniprotkb:CBLC(gene name)|psi-mi:CBLC(display_short)|uniprotkb:CBL3(gene name synonym)|uniprotkb:RNF57(gene name synonym)|uniprotkb:SH3-binding protein CBL-C(gene name synonym)|uniprotkb:SH3-binding protein CBL-3(gene name synonym)|uniprotkb:RING finger protein 57(gene name synonym)|uniprotkb:Signal transduction protein CBL-C(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-C(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10703997|imex:IM-22632-944	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000341505|ensembl:ENSP00000340250|ensembl:ENSP00000494162|refseq:NP_001124324.1|refseq:NP_036248.3|ensembl:ENSG00000142273(gene)|ensembl:ENST00000647358(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|rcsb pdb:3OP0|rcsb pdb:3VRN|rcsb pdb:3VRO|rcsb pdb:3VRP|rcsb pdb:3VRQ|rcsb pdb:3VRR|refseq:NM_012116.3(identity)|entrezgene/locuslink:23624(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:syzTzR6RGJzLv2EpDirSrli4ghs9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:2339E67A3A15C630|rigid:kwx4I8lb7QtYjAoPwhGN+FWmRRg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:P46108	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704008|imex:IM-22632-945	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:FAE00FB29A213E48|rigid:SdKd+YKNfmIFkiaT7TmjW1D2dRE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42684-3	uniprotkb:P46108	intact:EBI-10693977|ensembl:ENSP00000423578	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:p42684-3(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym)|uniprotkb:1ALCTL(isoform synonym)|uniprotkb:IC(isoform synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704019|imex:IM-22632-946	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143322(gene)|ensembl:ENST00000512653(transcript)|intact:EBI-1102694(isoform-parent)|uniprotkb:P42684-3(isoform-parent)|refseq:NM_005158.4(identity)|entrezgene/locuslink:27(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:gLzqA1k71ptItAHexZD/6P1Ilos9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:989013779C81C063|rigid:/ip1SzxNQ1pxbdjpijzxbYCKQE8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q13191	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-744027|uniprotkb:Q63Z43|uniprotkb:A8K9S7|uniprotkb:Q13192|uniprotkb:Q13193|uniprotkb:Q3LIC0|uniprotkb:Q8IVC5|uniprotkb:B7WNM4|intact:EBI-28969458|ensembl:ENSP00000377598|intact:EBI-8051403|intact:MINT-7907019	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:cblb_human(display_long)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704030|imex:IM-22632-947	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_733762.2|refseq:NP_001308717.1|ensembl:ENSP00000377598|ensembl:ENST00000403724|ensembl:ENSP00000384816|ensembl:ENST00000405772|ensembl:ENSP00000384938|refseq:XP_011511559.1|ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q13191|rcsb pdb:2AK5|rcsb pdb:2BZ8|rcsb pdb:2DO6|rcsb pdb:2J6F|rcsb pdb:2JNH|rcsb pdb:2LDR|rcsb pdb:2OOA|rcsb pdb:2OOB|rcsb pdb:3PFV|rcsb pdb:3VGO|rcsb pdb:3ZNI|reactome:R-HSA-983168|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|dip:DIP-33091N|entrezgene/locuslink:868(identity)|refseq:NM_170662.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606	intact-crc:E75D0897AD90CC5B|rigid:D5/N28Npe7FEobUizB151kissYw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43405	uniprotkb:Q96IP4	intact:EBI-78302|ensembl:ENSP00000364898|ensembl:ENSP00000364907	intact:EBI-954084|uniprotkb:Q5TF86|uniprotkb:Q8NFZ9|uniprotkb:Q9BW32|uniprotkb:Q9NXV5|uniprotkb:A8K7U4|ensembl:ENSP00000318298	psi-mi:ksyk_human(display_long)|uniprotkb:SYK(gene name)|psi-mi:SYK(display_short)|uniprotkb:Spleen tyrosine kinase(gene name synonym)|uniprotkb:p72-Syk(gene name synonym)	psi-mi:tet5a_human(display_long)|uniprotkb:TENT5A(gene name)|psi-mi:TENT5A(display_short)|uniprotkb:C6orf37(gene name synonym)|uniprotkb:FAM46A(gene name synonym)|uniprotkb:HBV X-transactivated gene 11 protein(gene name synonym)|uniprotkb:HBV XAg-transactivated protein 11(gene name synonym)|uniprotkb:XTP11(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704052|imex:IM-22632-949	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128524.1|refseq:NP_001167638.1|refseq:NP_001167639.1|refseq:NP_003168.2|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043313"(regulation of neutrophil degranulation)|go:"GO:0043366"(beta selection)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090237"(regulation of arachidonic acid secretion)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43405|rcsb pdb:1A81|rcsb pdb:1CSY|rcsb pdb:1CSZ|rcsb pdb:1XBA|rcsb pdb:1XBB|rcsb pdb:1XBC|rcsb pdb:3BUW|rcsb pdb:3EMG|rcsb pdb:3FQE|rcsb pdb:3FQH|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019815"(B cell receptor complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0032009"(early phagosome)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032752"(positive regulation of interleukin-3 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032928"(regulation of superoxide anion generation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0016170"(interleukin-15 receptor binding)|rcsb pdb:3FQS|rcsb pdb:3SRV|rcsb pdb:3TUB|rcsb pdb:3TUC|rcsb pdb:3TUD|rcsb pdb:3VF8|rcsb pdb:3VF9|rcsb pdb:4DFL|rcsb pdb:4DFN|rcsb pdb:4F4P|rcsb pdb:4FL1|rcsb pdb:4FL2|rcsb pdb:4FL3|rcsb pdb:4FYN|rcsb pdb:4FYO|rcsb pdb:4FZ6|rcsb pdb:4FZ7|rcsb pdb:4GFG|rcsb pdb:4I0R|ensembl:ENSG00000165025(gene)|ensembl:ENST00000375746(transcript)|ensembl:ENST00000375754(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002554"(serotonin secretion by platelet)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|rcsb pdb:4I0S|rcsb pdb:4I0T|rcsb pdb:4PUZ|rcsb pdb:4PV0|rcsb pdb:4PX6|rcsb pdb:4RSS|rcsb pdb:4RX7|rcsb pdb:4RX8|rcsb pdb:4RX9|rcsb pdb:4WNM|rcsb pdb:4XG2|rcsb pdb:4XG3|rcsb pdb:5TIU|rcsb pdb:5TR6|rcsb pdb:5TT7|rcsb pdb:5Y5T|rcsb pdb:5Y5U|rcsb pdb:6HM6|rcsb pdb:6HM7|rcsb pdb:6SSB|rcsb pdb:6VOV|rcsb pdb:6ZC0|rcsb pdb:6ZCP|rcsb pdb:6ZCQ|rcsb pdb:6ZCR|rcsb pdb:6ZCS|rcsb pdb:6ZCU|rcsb pdb:6ZCX|rcsb pdb:6ZCY|rcsb pdb:4XG4|reactome:R-HSA-114604|reactome:R-HSA-2029481|reactome:R-HSA-2029482|rcsb pdb:4XG7|rcsb pdb:4XG8|rcsb pdb:4XG9|rcsb pdb:4YJO|rcsb pdb:4YJP|rcsb pdb:4YJQ|rcsb pdb:4YJR|rcsb pdb:4YJS|rcsb pdb:4YJT|rcsb pdb:4YJU|rcsb pdb:4YJV|rcsb pdb:5C26|rcsb pdb:5C27|rcsb pdb:5CXH|rcsb pdb:5CXZ|rcsb pdb:5CY3|rcsb pdb:5GHV|rcsb pdb:5LMA|rcsb pdb:4XG6|rcsb pdb:5LMB|rcsb pdb:5T68|refseq:XP_011517248.1|refseq:XP_005252204.1|reactome:R-HSA-2029485|reactome:R-HSA-2424491|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9020558|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374|reactome:R-HSA-983695|dip:DIP-253N|entrezgene/locuslink:6850(identity)|refseq:NM_001174167.2(identity)	refseq:NP_060103.2|ensembl:ENSG00000112773(gene)|ensembl:ENST00000320172(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0048255"(mRNA stabilization)|go:"GO:1990817"(RNA adenylyltransferase activity)|interpro:IPR012937(Protein of unknown function DUF1693)|entrezgene/locuslink:55603(identity)|refseq:NM_017633.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FES (P07332)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:SAOtCMFKG07Wej573EklHjusYVA9606	rogid:RoYW7NusMegWdnScxOvz6GI6Kjo9606	intact-crc:685014784240D333|rigid:NntW2da6K1qNXXzpu8RKR7tIL7M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:Q9Y3I0	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-2107208|uniprotkb:Q6IAI0|uniprotkb:Q9BWL4|uniprotkb:Q9NTH1|uniprotkb:Q9P037|uniprotkb:Q9P0J3|uniprotkb:B2R6A8|intact:EBI-4399544|ensembl:ENSP00000216038	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:rtcb_human(display_long)|uniprotkb:3'-phosphate/5'-hydroxy nucleic acid ligase(gene name synonym)|uniprotkb:C22orf28(gene name synonym)|uniprotkb:HSPC117(orf name)|uniprotkb:RTCB(gene name)|psi-mi:RTCB(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704041|imex:IM-22632-948	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_055121.1|dip:DIP-46750N|ensembl:ENSG00000100220(gene)|ensembl:ENST00000216038(transcript)|go:"GO:0000971"(tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate)|go:"GO:0003723"(RNA binding)|go:"GO:0003972"("RNA ligase (ATP) activity")|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0017166"(vinculin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0072669"(tRNA-splicing ligase complex)|interpro:IPR001233(Protein of unknown function UPF0027)|interpro:IPR027513|interpro:IPR036025|mint:Q9Y3I0|reactome:R-HSA-6784531|entrezgene/locuslink:51493(identity)|refseq:NM_014306.4(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:URuCEq/DIn6DgR3jOb5fwnpDVXE9606	intact-crc:5D6E3491942FA70E|rigid:MObgY5jFXBCJWVIudWEen0u6MmA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42229	uniprotkb:Q8TAK6	intact:EBI-749537|uniprotkb:Q1KLZ6|ensembl:ENSP00000341208|ensembl:ENSP00000468749|ensembl:ENSP00000503262|ensembl:ENSP00000504449	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	psi-mi:sta5a_human(display_long)|uniprotkb:STAT5A(gene name)|psi-mi:STAT5A(display_short)|uniprotkb:STAT5(gene name synonym)	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704074|imex:IM-22632-951	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003143.2|refseq:NP_001275647.1|refseq:NP_001275648.1|refseq:NP_001275649.1|dip:DIP-396N|ensembl:ENSG00000126561(gene)|ensembl:ENST00000345506(transcript)|ensembl:ENST00000590949(transcript)|ensembl:ENST00000676585(transcript)|ensembl:ENST00000677301(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42229|reactome:R-HSA-1170546|reactome:R-HSA-1251985|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772|refseq:NM_003152.3(identity)|entrezgene/locuslink:6776(identity)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:KwM9uGM/He9Ome/Pzi6u/SgC6NY9606	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	intact-crc:145540E33CA68CC4|rigid:SIFLIL3ZisobfCjHLUDWwGnjvQA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43559	uniprotkb:P42679	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	intact:EBI-751664|uniprotkb:B3KNZ9|uniprotkb:Q9NST8|ensembl:ENSP00000308734	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:matk_human(display_long)|uniprotkb:Tyrosine-protein kinase CTK(gene name synonym)|uniprotkb:Protein kinase HYL(gene name synonym)|uniprotkb:Hematopoietic consensus tyrosine-lacking kinase(gene name synonym)|uniprotkb:MATK(gene name)|psi-mi:MATK(display_short)|uniprotkb:CTK(gene name synonym)|uniprotkb:HYL(gene name synonym)|uniprotkb:CSK homologous kinase(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704063|imex:IM-22632-950	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)|refseq:NM_006653.4(identity)|entrezgene/locuslink:10817(identity)	refseq:NP_002369.2|refseq:NP_647611.1|refseq:NP_647612.1|refseq:XP_011526320.1|ensembl:ENSG00000007264(gene)|ensembl:ENST00000310132(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1JWO|rcsb pdb:1X6G|rcsb pdb:3US4|reactome:R-HSA-8863795|entrezgene/locuslink:4145(identity)|refseq:NM_139355.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	rogid:zA5Bl6NIDDz31AJcm6u02v4bEe89606	intact-crc:14A03F054CD5AED6|rigid:GtZ7lYuxm5gyc3AtDZvfxEOCTgY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:P42229	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-749537|uniprotkb:Q1KLZ6|ensembl:ENSP00000341208|ensembl:ENSP00000468749|ensembl:ENSP00000503262|ensembl:ENSP00000504449	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:sta5a_human(display_long)|uniprotkb:STAT5A(gene name)|psi-mi:STAT5A(display_short)|uniprotkb:STAT5(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704085|imex:IM-22632-952	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	refseq:NP_003143.2|refseq:NP_001275647.1|refseq:NP_001275648.1|refseq:NP_001275649.1|dip:DIP-396N|ensembl:ENSG00000126561(gene)|ensembl:ENST00000345506(transcript)|ensembl:ENST00000590949(transcript)|ensembl:ENST00000676585(transcript)|ensembl:ENST00000677301(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42229|reactome:R-HSA-1170546|reactome:R-HSA-1251985|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772|refseq:NM_003152.3(identity)|entrezgene/locuslink:6776(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:KwM9uGM/He9Ome/Pzi6u/SgC6NY9606	intact-crc:893DA8792C030E6A|rigid:eMJKhgxaiYWwXmGBFh52gBiLD0U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11277	uniprotkb:P42224	intact:EBI-514908|uniprotkb:Q15510|uniprotkb:Q15519|ensembl:ENSP00000374370	intact:EBI-1057697|uniprotkb:Q53S88|uniprotkb:Q53XW4|uniprotkb:B2RCA0|uniprotkb:Q9UDL5|uniprotkb:A8K989|uniprotkb:D2KFR8|uniprotkb:Q68D00|uniprotkb:D3DPI7|ensembl:ENSP00000354394|ensembl:ENSP00000386244|ensembl:ENSP00000388240|ensembl:ENSP00000438703	psi-mi:sptb1_human(display_long)|uniprotkb:Beta-I spectrin(gene name synonym)|uniprotkb:SPTB(gene name)|psi-mi:SPTB(display_short)|uniprotkb:SPTB1(gene name synonym)	psi-mi:stat1_human(display_long)|uniprotkb:STAT1(gene name)|psi-mi:STAT1(display_short)|uniprotkb:Transcription factor ISGF-3 components p91/p84(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704096|imex:IM-22632-953	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000338.3|refseq:NP_001020029.1|refseq:XP_005268080.1|refseq:XP_016877101.1|refseq:XP_016877103.1|dip:DIP-1021N|ensembl:ENSG00000070182(gene)|ensembl:ENST00000389720(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0008091"(spectrin)|go:"GO:0009986"(cell surface)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031235"(intrinsic component of the cytoplasmic side of the plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051015"(actin filament binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|rcsb pdb:1S35|rcsb pdb:3EDU|rcsb pdb:3F57|rcsb pdb:3KBT|rcsb pdb:3KBU|rcsb pdb:3LBX|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878|entrezgene/locuslink:6710(identity)|refseq:NM_001024858.2(identity)	refseq:NP_009330.1|refseq:NP_644671.1|rcsb pdb:1YVL|rcsb pdb:2KA6|rcsb pdb:3WWT|reactome:R-HSA-1059683|reactome:R-HSA-1169408|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8939902|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9013508|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-909733|rcsb pdb:1BF5|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-912694|refseq:XP_006712781.1|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|ensembl:ENSG00000115415(gene)|ensembl:ENST00000361099(transcript)|ensembl:ENST00000409465(transcript)|ensembl:ENST00000415035(transcript)|ensembl:ENST00000540176(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|mint:P42224|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|dip:DIP-46140N|refseq:NM_139266.2(identity)|entrezgene/locuslink:6772(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), FES (P07332), FYN (P06241), JAK2 (O60674)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:pMUYFaSR/cKouM4GMi36sGK6aOU9606	rogid:a2ZnhdFZkctbjaXLpsYNJ3q5Cv49606	intact-crc:BEAE46051CD67FDC|rigid:yymDRYobX8oeik/Okwk27J1b6OI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:P41134	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-1215527|uniprotkb:O00651|uniprotkb:O00652|uniprotkb:Q16371|uniprotkb:Q16377|uniprotkb:Q5TE66|uniprotkb:Q5TE67|uniprotkb:Q969Z7|uniprotkb:Q9H0Z5|uniprotkb:Q9H109|uniprotkb:A8K537|uniprotkb:E1P5L4|ensembl:ENSP00000365280	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:id1_human(display_long)|uniprotkb:ID1(gene name)|psi-mi:ID1(display_short)|uniprotkb:ID(gene name synonym)|uniprotkb:Inhibitor of DNA binding 1(gene name synonym)|uniprotkb:BHLHB24(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 24(gene name synonym)|uniprotkb:Inhibitor of differentiation 1(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704107|imex:IM-22632-954	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	refseq:NP_002156.2|refseq:NP_851998.1|dip:DIP-38112N|ensembl:ENSG00000125968(gene)|ensembl:ENST00000376112(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010621"(negative regulation of transcription by transcription factor localization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036164"(cell-abiotic substrate adhesion)|go:"GO:0005654"(nucleoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070628"(proteasome binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901342"(regulation of vasculature development)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR026052|interpro:IPR036638|mint:P41134|reactome:R-HSA-2559585|reactome:R-HSA-9031628|entrezgene/locuslink:3397(identity)|refseq:NM_002165.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:IVXAJsAnQLB8hVutO0qX4bS8gXM9606	intact-crc:8C55D121FC2A9238|rigid:4RJMdf+mbm5pD7ZkujZSZDO2+SQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763-2	uniprotkb:Q5VWN6	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	intact:EBI-745958|uniprotkb:Q2YD91|uniprotkb:Q5VWN5|uniprotkb:Q6ZRQ8|uniprotkb:Q8IVG4|uniprotkb:Q9BUZ7|uniprotkb:Q9H5J9|uniprotkb:Q9H7A4|uniprotkb:Q9H996|uniprotkb:Q9NXA1|intact:EBI-28974916|ensembl:ENSP00000328426	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:taso2_human(display_long)|uniprotkb:TASOR2(gene name)|psi-mi:TASOR2(display_short)|uniprotkb:C10orf18(gene name synonym)|uniprotkb:FAM208B(gene name synonym)|uniprotkb:KIAA2006(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704118|imex:IM-22632-955	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_060252.4|ensembl:ENSP00000328426|refseq:XP_011517827.1|refseq:XP_016871852.1|refseq:XP_016871854.1|ensembl:ENSG00000108021(gene)|ensembl:ENST00000328090(transcript)|go:"GO:0005829"(cytosol)|interpro:IPR022168|interpro:IPR022188|mint:Q5VWN6|go:"GO:0005654"(nucleoplasm)|refseq:XP_005252532.1|refseq:XP_005252537.1|refseq:XP_005252538.1|refseq:XP_005252539.1|refseq:NP_001308712.1|refseq:NP_001308713.1|refseq:NP_001308714.1|entrezgene/locuslink:54906(identity)|refseq:NM_017782.4(identity)	-	isoform-comment:Contains a phosphotyrosine at position 704.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	rogid:mTRMzWB45dZojaB1ZrsaQRT48YQ9606	intact-crc:988883868C124E57|rigid:AFKvuXLNDpwSG6WqUQDcDDKW4G4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7L591-3	uniprotkb:P40763-2	intact:EBI-10694655|ensembl:ENSP00000325174	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704129|imex:IM-22632-956	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	isoform-comment:Contains a phosphotyrosine at position 704.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:4BA3FA8796C04338|rigid:q/5uXD/qP56EGmXrKrY9mfqWS90	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEC7	uniprotkb:P40763-2	intact:EBI-8469616|intact:MINT-6779113|uniprotkb:Q9H8S3|uniprotkb:A8MVD3|uniprotkb:A8K8J0|uniprotkb:H9KV97|ensembl:ENSP00000353695|ensembl:ENSP00000378216|ensembl:ENSP00000422354	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:gstcd_human(display_long)|uniprotkb:GSTCD(gene name)|psi-mi:GSTCD(display_short)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704140|imex:IM-22632-957	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530550.1|refseq:XP_011530551.1|refseq:XP_011530554.1|refseq:NP_001026890.2|refseq:NP_079027.2|refseq:XP_005263279.1|ensembl:ENSG00000138780(gene)|ensembl:ENST00000360505(transcript)|ensembl:ENST00000394728(transcript)|ensembl:ENST00000515279(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR025714|interpro:IPR029063|interpro:IPR036282|mint:Q8NEC7|entrezgene/locuslink:79807(identity)|refseq:NM_001031720.3(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	comment:mint|comment:homomint	isoform-comment:Contains a phosphotyrosine at position 704.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:jg34D624i8iGCgGTedM+tfGgmRQ9606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:79D29481472FA7AF|rigid:mPsQpbEB1f2iYc016YDBHQO5ZM4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBX0	uniprotkb:P40763-2	intact:EBI-8470369|intact:MINT-8417673|uniprotkb:Q99667|uniprotkb:Q52LC5|ensembl:ENSP00000295934|ensembl:ENSP00000498190	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:hesx1_human(display_long)|uniprotkb:HESX1(gene name)|psi-mi:HESX1(display_short)|uniprotkb:HANF(gene name synonym)|uniprotkb:Homeobox protein ANF(gene name synonym)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704151|imex:IM-22632-958	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011532506.1|refseq:XP_011532507.1|refseq:NP_003856.1|refseq:XP_005265583.1|refseq:XP_006713442.1|refseq:XP_016862910.1|ensembl:ENSG00000163666(gene)|ensembl:ENST00000295934(transcript)|ensembl:ENST00000647958(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008406"(gonad development)|go:"GO:0010467"(gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043584"(nose development)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR043402|mint:Q9UBX0|rcsb pdb:2K40|refseq:NM_003865.2(identity)|entrezgene/locuslink:8820(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	comment:mint|comment:homomint	isoform-comment:Contains a phosphotyrosine at position 704.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:ZnU6Y5Ypmp2rPpmN9ONoyIJgGhg9606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:2F7B005DBFB10023|rigid:Zkw7BcQ68lFYZx5pDU2v+YMJEh0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763-2	uniprotkb:Q9Y4J8-9	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	intact:EBI-10692782|ensembl:ENSP00000451516|ensembl:ENSP00000506928|ensembl:ENSP00000508348	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:q9y4j8-9(display_long)|uniprotkb:DTNA(gene name)|psi-mi:DTNA(display_short)|uniprotkb:Alpha-dystrobrevin(gene name synonym)|uniprotkb:DRP3(gene name synonym)|uniprotkb:Dystrophin-related protein 3(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704162|imex:IM-22632-959	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	ensembl:ENSG00000134769(gene)|ensembl:ENST00000554864(transcript)|ensembl:ENST00000684610(transcript)|ensembl:ENST00000684734(transcript)|intact:EBI-949471(isoform-parent)|refseq:NM_001128175.1(identity)|entrezgene/locuslink:1837(identity)	-	isoform-comment:Contains a phosphotyrosine at position 704.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	rogid:TACvlVb+y+/F26d1ZiArVJcEFFI9606	intact-crc:14957AE4C3AE356A|rigid:xsdID5nSqrqzPlG9aV8zCTAzCAI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763-2	uniprotkb:Q7Z417	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704173|imex:IM-22632-960	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417|entrezgene/locuslink:57532(identity)|refseq:NM_020772.2(identity)	-	isoform-comment:Contains a phosphotyrosine at position 704.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	intact-crc:F2206D7EC4B11CED|rigid:ST+pt1NdIQw+0SkQgQd2eLdQtCY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:P40763-2	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704184|imex:IM-22632-961	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	-	isoform-comment:Contains a phosphotyrosine at position 704.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:602CB6097BC5F59B|rigid:gQL7oBFA+z4YtXj1NUJWcJRsr4A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763-2	uniprotkb:Q9NSI6-4	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	intact:EBI-10693038|ensembl:ENSP00000342106	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:q9nsi6-4(display_long)|uniprotkb:BRWD1(gene name)|psi-mi:BRWD1(display_short)|uniprotkb:C21orf107(gene name synonym)|uniprotkb:WD repeat-containing protein 9(gene name synonym)|uniprotkb:WDR9(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704195|imex:IM-22632-962	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	intact:EBI-1996384(isoform-parent)|uniprotkb:Q9NSI6-4(isoform-parent)|ensembl:ENSG00000185658(gene)|ensembl:ENST00000341322(transcript)|entrezgene/locuslink:54014(identity)|refseq:NM_001007246.2(identity)	-	isoform-comment:Contains a phosphotyrosine at position 704.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	rogid:vfir0aZ5Af/ptv8i+BAAGpNn5wg9606	intact-crc:26F6B4677D6344EF|rigid:ScvXbPpUiw+rR96OssJSTiKfQhQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763-2	uniprotkb:O60496	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	intact:EBI-1046024|uniprotkb:Q8N5A4|ensembl:ENSP00000276420	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:dok2_human(display_long)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:DOK2(gene name)|psi-mi:DOK2(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704206|imex:IM-22632-963	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_003965.2|ensembl:ENSG00000147443(gene)|ensembl:ENST00000276420(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|rcsb pdb:2D9W|rcsb pdb:2DLW|reactome:R-HSA-210993|reactome:R-HSA-8853659|go:"GO:0007166"(cell surface receptor signaling pathway)|entrezgene/locuslink:9046(identity)|refseq:NM_003974.2(identity)	-	isoform-comment:Contains a phosphotyrosine at position 704.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	rogid:gBEpjlq3kc6oYF0uVqPz04hfrHw9606	intact-crc:CDFC6149B3A2B8F8|rigid:a5w5MlMI/c0o+Ia1fcHu0ZPytl8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763-2	uniprotkb:P42684-3	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	intact:EBI-10693977|ensembl:ENSP00000423578	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:p42684-3(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym)|uniprotkb:1ALCTL(isoform synonym)|uniprotkb:IC(isoform synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704217|imex:IM-22632-964	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	ensembl:ENSG00000143322(gene)|ensembl:ENST00000512653(transcript)|intact:EBI-1102694(isoform-parent)|uniprotkb:P42684-3(isoform-parent)|refseq:NM_005158.4(identity)|entrezgene/locuslink:27(identity)	-	isoform-comment:Contains a phosphotyrosine at position 704.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	rogid:gLzqA1k71ptItAHexZD/6P1Ilos9606	intact-crc:3B0969B0C4BEFB6B|rigid:Q13Pfuptk8HvzJqunDmgFZ3MGG0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00459	uniprotkb:P40763-2	intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704239|imex:IM-22632-966	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409|entrezgene/locuslink:5296(identity)|refseq:NM_005027.3(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	-	isoform-comment:Contains a phosphotyrosine at position 704.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:AFB10FA0B00BE478|rigid:YjsSOIwDo4Hj7tFZ+8eBcDrR0oY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:P40763-2	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704228|imex:IM-22632-965	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	-	isoform-comment:Contains a phosphotyrosine at position 704.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:9B25647D6604D5DD|rigid:LeQAOWxWF+hVz2SCoay8BQ8vt8c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06239	uniprotkb:P40763-2	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	intact:EBI-10692009|ensembl:ENSP00000384943|ensembl:ENSP00000503237|ensembl:ENSP00000503574	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:p40763-2(display_long)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)|uniprotkb:Acute-phase response factor(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704250|imex:IM-22632-967	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374|entrezgene/locuslink:3932(identity)|refseq:NM_001042771.2(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000404395(transcript)|ensembl:ENST00000677723(transcript)|ensembl:ENST00000679014(transcript)|intact:EBI-518675(isoform-parent)|uniprotkb:P40763-2(isoform-parent)|refseq:NM_003150.3(identity)|entrezgene/locuslink:6774(identity)	-	-	isoform-comment:Contains a phosphotyrosine at position 704.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	rogid:/1UcPsO8RrgzHRF25zP2b9DTN0M9606	intact-crc:CB57A24424F5A24B|rigid:Nb9U55YUPEJON4LMX/zsrU+61J8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-10696506	uniprotkb:P40763	-	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:mpzl1(display_short)|psi-mi:EBI-10696506(display_long)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704261|imex:IM-22632-968	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	entrezgene/locuslink:9019(identity)|refseq:NM_003953.5(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	no-uniprot-update:	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:1GWPVDd8qhs7qSMespdwAU9jUxY9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:DC5FF59D30D14039|rigid:p5WPKkhPReBhFU+nR7iqRsFV8+o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60409	uniprotkb:P40763	intact:EBI-10172290|uniprotkb:Q70LJ2|uniprotkb:Q0VDJ8|ensembl:ENSP00000476821	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:kr107_human(display_long)|uniprotkb:KRTAP10-7(gene name)|psi-mi:KRTAP10-7(display_short)|uniprotkb:High sulfur keratin-associated protein 10.7(gene name synonym)|uniprotkb:KAP10.7(gene name synonym)|uniprotkb:KAP18-7(gene name synonym)|uniprotkb:KRTAP10.7(gene name synonym)|uniprotkb:KRTAP18-7(gene name synonym)|uniprotkb:KRTAP18.7(gene name synonym)|uniprotkb:Keratin-associated protein 10.7(gene name synonym)|uniprotkb:Keratin-associated protein 18-7(gene name synonym)|uniprotkb:Keratin-associated protein 18.7(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704272|imex:IM-22632-969	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_941962.1|ensembl:ENSG00000272804(gene)|ensembl:ENST00000609664(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0045095"(keratin filament)|interpro:IPR002494(Keratin, high sulphur B2 protein)|reactome:R-HSA-6805567|entrezgene/locuslink:386675(identity)|refseq:NM_198689.2(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2020/12/11	rogid:XmtWE6zSOr/RhRJH9yR31sPW1eY9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:8A66778114A21E00|rigid:PJpYGEjyJj+4uzvmV4eTADhM86M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14847	uniprotkb:P40763	intact:EBI-742828|uniprotkb:Q96ED2|uniprotkb:Q96IG0|ensembl:ENSP00000325240|ensembl:ENSP00000392853|uniprotkb:B4DGQ0	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:lasp1_human(display_long)|uniprotkb:Metastatic lymph node gene 50 protein(gene name synonym)|uniprotkb:LASP1(gene name)|psi-mi:LASP1(display_short)|uniprotkb:MLN50(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704283|imex:IM-22632-970	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006139.1|refseq:NP_001258537.1|ensembl:ENSG00000002834(gene)|ensembl:ENST00000318008(transcript)|ensembl:ENST00000435347(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006811"(ion transport)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|interpro:IPR000900(Nebulin 35 residue motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR035630|interpro:IPR036028|mint:Q14847|rcsb pdb:3I35|refseq:NM_006148.3(identity)|entrezgene/locuslink:3927(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:Oa+FdJXeQhahYTqVrHYk6yBrUWI9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:3241FBB673B97885|rigid:BaX/N0CjH+B1nLB02HXFs45Eqzc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:Q6P1L5	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-3893327|uniprotkb:Q53QZ5|uniprotkb:Q585T9|uniprotkb:Q8N8W1|uniprotkb:Q96Q34|ensembl:ENSP00000376071	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:f117b_human(display_long)|uniprotkb:FAM117B(gene name)|psi-mi:FAM117B(display_short)|uniprotkb:ALS2CR13(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704305|imex:IM-22632-972	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_775782.2|ensembl:ENST00000392238(transcript)|interpro:IPR026641|interpro:IPR026642|mint:Q6P1L5|ensembl:ENSG00000138439(gene)|entrezgene/locuslink:150864(identity)|refseq:NM_173511.3(identity)	-	crc64:6C00632211C8012D	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:ADo2dQPS1oosYCBJSZHY8jHcjeA9606	intact-crc:75F0BE494342C86D|rigid:8vasp6NgoPJhvrBJp6E2u98zY24	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:Q5VWN6	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-745958|uniprotkb:Q2YD91|uniprotkb:Q5VWN5|uniprotkb:Q6ZRQ8|uniprotkb:Q8IVG4|uniprotkb:Q9BUZ7|uniprotkb:Q9H5J9|uniprotkb:Q9H7A4|uniprotkb:Q9H996|uniprotkb:Q9NXA1|intact:EBI-28974916|ensembl:ENSP00000328426	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:taso2_human(display_long)|uniprotkb:TASOR2(gene name)|psi-mi:TASOR2(display_short)|uniprotkb:C10orf18(gene name synonym)|uniprotkb:FAM208B(gene name synonym)|uniprotkb:KIAA2006(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704294|imex:IM-22632-971	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_060252.4|ensembl:ENSP00000328426|refseq:XP_011517827.1|refseq:XP_016871852.1|refseq:XP_016871854.1|ensembl:ENSG00000108021(gene)|ensembl:ENST00000328090(transcript)|go:"GO:0005829"(cytosol)|interpro:IPR022168|interpro:IPR022188|mint:Q5VWN6|go:"GO:0005654"(nucleoplasm)|refseq:XP_005252532.1|refseq:XP_005252537.1|refseq:XP_005252538.1|refseq:XP_005252539.1|refseq:NP_001308712.1|refseq:NP_001308713.1|refseq:NP_001308714.1|entrezgene/locuslink:54906(identity)|refseq:NM_017782.4(identity)	-	crc64:6C00632211C8012D	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:mTRMzWB45dZojaB1ZrsaQRT48YQ9606	intact-crc:D92612720FD4AC8C|rigid:Y4yKrmRBRbnp9YjCK9wqm3XXnTY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7L591-3	uniprotkb:P40763	intact:EBI-10694655|ensembl:ENSP00000325174	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:q7l591-3(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704316|imex:IM-22632-973	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146094(gene)|ensembl:ENST00000312943(transcript)|intact:EBI-2834978(isoform-parent)|uniprotkb:Q7L591-3(isoform-parent)|entrezgene/locuslink:79930(identity)|refseq:NM_001144875.1(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	isoform-comment:"No experimental confirmation available. Ref.3 (AAH04564) sequence is in conflict in position: 302:R->C."	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rxwhsRX7/bFxIUuMo+xrgkEB9t09606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:B69003B57B0F0BF6|rigid:ArWdpcDWTCIQNaXJ9/DzNQFB8vw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEC7	uniprotkb:P40763	intact:EBI-8469616|intact:MINT-6779113|uniprotkb:Q9H8S3|uniprotkb:A8MVD3|uniprotkb:A8K8J0|uniprotkb:H9KV97|ensembl:ENSP00000353695|ensembl:ENSP00000378216|ensembl:ENSP00000422354	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:gstcd_human(display_long)|uniprotkb:GSTCD(gene name)|psi-mi:GSTCD(display_short)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704327|imex:IM-22632-974	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530550.1|refseq:XP_011530551.1|refseq:XP_011530554.1|refseq:NP_001026890.2|refseq:NP_079027.2|refseq:XP_005263279.1|ensembl:ENSG00000138780(gene)|ensembl:ENST00000360505(transcript)|ensembl:ENST00000394728(transcript)|ensembl:ENST00000515279(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR025714|interpro:IPR029063|interpro:IPR036282|mint:Q8NEC7|entrezgene/locuslink:79807(identity)|refseq:NM_001031720.3(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	comment:mint|comment:homomint	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:jg34D624i8iGCgGTedM+tfGgmRQ9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:11A28A88601FD703|rigid:DSmBtS7elbJriLfoaugM8NC3/rY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBX0	uniprotkb:P40763	intact:EBI-8470369|intact:MINT-8417673|uniprotkb:Q99667|uniprotkb:Q52LC5|ensembl:ENSP00000295934|ensembl:ENSP00000498190	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:hesx1_human(display_long)|uniprotkb:HESX1(gene name)|psi-mi:HESX1(display_short)|uniprotkb:HANF(gene name synonym)|uniprotkb:Homeobox protein ANF(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704338|imex:IM-22632-975	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011532506.1|refseq:XP_011532507.1|refseq:NP_003856.1|refseq:XP_005265583.1|refseq:XP_006713442.1|refseq:XP_016862910.1|ensembl:ENSG00000163666(gene)|ensembl:ENST00000295934(transcript)|ensembl:ENST00000647958(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008406"(gonad development)|go:"GO:0010467"(gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043584"(nose development)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR043402|mint:Q9UBX0|rcsb pdb:2K40|refseq:NM_003865.2(identity)|entrezgene/locuslink:8820(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	comment:mint|comment:homomint	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ZnU6Y5Ypmp2rPpmN9ONoyIJgGhg9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:606B5B0045E807E2|rigid:u2I/72bwiU28JxbCpcp7/K5iZEU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y4J8-9	uniprotkb:P40763	intact:EBI-10692782|ensembl:ENSP00000451516|ensembl:ENSP00000506928|ensembl:ENSP00000508348	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:q9y4j8-9(display_long)|uniprotkb:DTNA(gene name)|psi-mi:DTNA(display_short)|uniprotkb:Alpha-dystrobrevin(gene name synonym)|uniprotkb:DRP3(gene name synonym)|uniprotkb:Dystrophin-related protein 3(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704360|imex:IM-22632-977	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134769(gene)|ensembl:ENST00000554864(transcript)|ensembl:ENST00000684610(transcript)|ensembl:ENST00000684734(transcript)|intact:EBI-949471(isoform-parent)|refseq:NM_001128175.1(identity)|entrezgene/locuslink:1837(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:TACvlVb+y+/F26d1ZiArVJcEFFI9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:9BDBBA86A5B20C53|rigid:l+0WO9uyJwHEWCvC14XwFEfrhXw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:Q9Y3P9	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-1057545|uniprotkb:Q05CW2|uniprotkb:Q6ZMY1|uniprotkb:Q9HA28|uniprotkb:Q9P0E2|uniprotkb:Q9UG67|intact:EBI-2948690|uniprotkb:B9A6L2|ensembl:ENSP00000362751	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:rbgp1_human(display_long)|uniprotkb:RABGAP1(gene name)|psi-mi:RABGAP1(display_short)|uniprotkb:HSPC094(orf name)|uniprotkb:Rab6 GTPase-activating protein GAPCenA(gene name synonym)|uniprotkb:GAP and centrosome-associated protein(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704349|imex:IM-22632-976	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	refseq:XP_011516742.1|refseq:XP_011516743.1|refseq:NP_036329.3|ensembl:ENSG00000011454(gene)|ensembl:ENST00000373647(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0015631"(tubulin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022164|interpro:IPR033185|interpro:IPR035969|mint:Q9Y3P9|rcsb pdb:4NC6|reactome:R-HSA-8854214|refseq:XP_016870056.1|refseq:XP_016870057.1|refseq:XP_016870058.1|refseq:NM_012197.3(identity)|entrezgene/locuslink:23637(identity)	-	crc64:6C00632211C8012D	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:yGnx7q5tyqYfpbeVDwZ8IKI1o+k9606	intact-crc:8AC01F541D0FED48|rigid:Km7Mra6GdbQsiOdGNk8Fh3/Xsmk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:P22681	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704382|imex:IM-22632-979	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	-	crc64:6C00632211C8012D	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:D60931B5042A0AFA|rigid:koIn9JJX7tGbPUymbJ3oDIz2CNU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:Q9NP31	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704371|imex:IM-22632-978	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	crc64:6C00632211C8012D	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:45866E7D23643F89|rigid:n2XQnkZPjaygUtNNHAR1X6Mg7VM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZVU3	uniprotkb:P40763	intact:EBI-10692309	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:q6zvu3_human(display_long)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704404|imex:IM-22632-981	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000980(SH2 motif)|go:"GO:0007165"(signal transduction)|interpro:IPR035847|interpro:IPR035848|interpro:IPR036860|entrezgene/locuslink:6452(identity)|refseq:XM_006713911.1(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:aXLhmmekzxHm9dx2GYbVhkLRFG89606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:FEAFA5594F302AF7|rigid:RJy+ItFSSW6XVi1+Acs0qj1EgGA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03181-2	uniprotkb:P40763	intact:EBI-10223258|ensembl:ENSP00000337063	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:q03181-2(display_long)|uniprotkb:PPARD(gene name)|psi-mi:PPARD(display_short)|uniprotkb:NR1C2(gene name synonym)|uniprotkb:NUCI(gene name synonym)|uniprotkb:Nuclear hormone receptor 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group C member 2(gene name synonym)|uniprotkb:PPARB(gene name synonym)|uniprotkb:Peroxisome proliferator-activated receptor beta(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704393|imex:IM-22632-980	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000112033(gene)|ensembl:ENST00000337400(transcript)|intact:EBI-6426768(isoform-parent)|uniprotkb:Q03181-2(isoform-parent)|refseq:NM_177435.2(identity)|entrezgene/locuslink:5467(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:f/1hsB8raZhYd9o39f/T5XI5oWs9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:566C332649326E17|rigid:j0ftkdZRwzRy63SBIwr6tEmOQes	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:Q92569	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704426|imex:IM-22632-983	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	crc64:6C00632211C8012D	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:A5D77B59EF9B3649|rigid:LjLBf25PFr/wMjiY4SIdMT+f3Z8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:Q86WK9	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-10694587|uniprotkb:Q86VE4|uniprotkb:A2A2D3|uniprotkb:Q5XKF9|ensembl:ENSP00000363414|ensembl:ENSP00000502514	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:paqr7_human(display_long)|uniprotkb:Membrane progesterone P4 receptor alpha(gene name synonym)|uniprotkb:Membrane progesterone receptor alpha(gene name synonym)|uniprotkb:Progesterone and adipoQ receptor family member 7(gene name synonym)|uniprotkb:PAQR7(gene name)|psi-mi:PAQR7(display_short)|uniprotkb:MRPA(gene name synonym)|uniprotkb:Progestin and adipoQ receptor family member 7(gene name synonym)|uniprotkb:Progestin and adipoQ receptor family member VII(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704415|imex:IM-22632-982	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	refseq:NP_848509.1|refseq:XP_005245802.1|refseq:XP_005245803.1|refseq:XP_011539163.1|refseq:XP_011539164.1|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0048477"(oogenesis)|go:"GO:0048545"(response to steroid hormone)|interpro:IPR004254(Hly-III related)|ensembl:ENSG00000182749(gene)|ensembl:ENST00000374296(transcript)|ensembl:ENST00000675840(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|entrezgene/locuslink:164091(identity)|refseq:NM_178422.5(identity)	-	crc64:6C00632211C8012D	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:NR1qCNOh+qu4PyZ+cLiJX9RTmvE9606	intact-crc:1419BD274777974F|rigid:F2J31OsR6Hm2Vqk1DTFNtwQMI8s	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NVE4	uniprotkb:P40763	intact:EBI-749261|uniprotkb:Q8NE76|ensembl:ENSP00000328487	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:ccd87_human(display_long)|uniprotkb:CCDC87(gene name)|psi-mi:CCDC87(display_short)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704437|imex:IM-22632-984	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060689.2|ensembl:ENSP00000328487|ensembl:ENSG00000182791(gene)|ensembl:ENST00000333861(transcript)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0030154"(cell differentiation)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:2000344"(positive regulation of acrosome reaction)|interpro:IPR037383|refseq:NM_018219.2(identity)|entrezgene/locuslink:55231(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:SfXyZIfbueunH5g/6biF1Pabyrc9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:04B1F727C46D629B|rigid:5moLGP1cgmG1dgUAf/LfOWYuQ6E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27986-2	uniprotkb:P40763	intact:EBI-9090282|ensembl:ENSP00000338554	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704448|imex:IM-22632-985	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:688C3B462B8C66AA|rigid:JnThNIWbveuOpAq70IKPZzQx+zk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35219	uniprotkb:P40763	intact:EBI-718700|uniprotkb:Q32MY2|uniprotkb:A8K0A5|uniprotkb:B3KQZ7|ensembl:ENSP00000314407	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:cah8_human(display_long)|uniprotkb:Carbonic anhydrase VIII(gene name synonym)|uniprotkb:CA8(gene name)|psi-mi:CA8(display_short)|uniprotkb:CALS(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704459|imex:IM-22632-986	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004047.3|refseq:NP_001308766.1|refseq:NP_001308767.1|refseq:NP_001308768.1|ensembl:ENSG00000178538(gene)|ensembl:ENST00000317995(transcript)|go:"GO:0004089"(carbonate dehydratase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016836"(hydro-lyase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR001148(Carbonic anhydrase, eukaryotic)|interpro:IPR018338|interpro:IPR023561|interpro:IPR036398|interpro:IPR041877|rcsb pdb:2W2J|entrezgene/locuslink:767(identity)|refseq:NM_004056.4(identity)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	-	-	crc64:6C00632211C8012D	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:ExWihL00UgXcbYaCfzAXK8g5i5E9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:023EB08F1BFFB2E8|rigid:F7itfEeXgkHY8FPNf5I+JCZY/TQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40763	uniprotkb:P49137	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-993299|uniprotkb:Q8IYD6|uniprotkb:Q5SY30|uniprotkb:Q5SY41|ensembl:ENSP00000356070	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:mapk2_human(display_long)|uniprotkb:MAPKAPK2(gene name)|psi-mi:MAPKAPK2(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704470|imex:IM-22632-987	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N|refseq:NM_139276.2(identity)|entrezgene/locuslink:6774(identity)	go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENSG00000162889(gene)|ensembl:ENST00000367103(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048839"(inner ear development)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:P49137|rcsb pdb:1KWP|rcsb pdb:1NXK|rcsb pdb:1NY3|rcsb pdb:2JBO|rcsb pdb:2JBP|rcsb pdb:2OKR|rcsb pdb:2ONL|rcsb pdb:2OZA|rcsb pdb:2P3G|rcsb pdb:2PZY|rcsb pdb:3A2C|rcsb pdb:3FPM|rcsb pdb:3FYJ|rcsb pdb:3FYK|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450302|rcsb pdb:3GOK|rcsb pdb:3KA0|rcsb pdb:3KC3|rcsb pdb:3KGA|rcsb pdb:3M2W|rcsb pdb:3M42|rcsb pdb:3R2B|rcsb pdb:3R2Y|rcsb pdb:3R30|rcsb pdb:3WI6|rcsb pdb:4TYH|rcsb pdb:6T8X|rcsb pdb:6TCA|reactome:R-HSA-171007|reactome:R-HSA-199920|reactome:R-HSA-2142691|reactome:R-HSA-2559580|reactome:R-HSA-3371453|reactome:R-HSA-4420097|refseq:NP_004750.1|refseq:NP_116584.2|dip:DIP-35671N|entrezgene/locuslink:9261(identity)|refseq:NM_032960.3(identity)	-	crc64:6C00632211C8012D	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:iOzgeWqkVeJtasBfXoF50t7R2dE9606	intact-crc:DC8914ED1D2426F1|rigid:9WfFWgzig2FhxE+gSU4f7/0su2w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75815	uniprotkb:P35568	intact:EBI-702336|uniprotkb:Q6UW40|uniprotkb:Q9BR50|uniprotkb:D3DT43|uniprotkb:Q5TEW3|ensembl:ENSP00000260502|ensembl:ENSP00000359263|ensembl:ENSP00000359264	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	psi-mi:bcar3_human(display_long)|uniprotkb:SH2 domain-containing protein 3B(gene name synonym)|uniprotkb:Novel SH2-containing protein 2(gene name synonym)|uniprotkb:BCAR3(gene name)|psi-mi:BCAR3(display_short)|uniprotkb:NSP2(gene name synonym)|uniprotkb:SH2D3B(gene name synonym)|uniprotkb:UNQ271/PRO308(orf name)	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704481|imex:IM-22632-988	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003558.1|refseq:NP_001248339.1|refseq:NP_001295180.1|refseq:NP_001248337.1|refseq:NP_001248338.1|refseq:XP_016857969.1|dip:DIP-33857N|ensembl:ENSG00000137936(gene)|ensembl:ENST00000260502(transcript)|ensembl:ENST00000370243(transcript)|ensembl:ENST00000370244(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042493"|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0086100"(endothelin receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR023578|interpro:IPR028849|interpro:IPR036860|interpro:IPR036964|interpro:IPR044102|mint:O75815|rcsb pdb:3T6A|refseq:NM_003567.3(identity)|entrezgene/locuslink:8412(identity)	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772|refseq:NM_005544.2(identity)|entrezgene/locuslink:3667(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FRK (P42685), FYN (P06241), HCK (P08631), LYN (P07948), PTK2 (Q05397), SRC (P12931), TNK1 (Q13470), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:r4mh2ZDGa0AleYRBV+oAiDds1+w9606	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	intact-crc:565178254B8AF517|rigid:hXY4VdfEmUyftOI+vwotwWGjjWM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29350-3	uniprotkb:Q05397	intact:EBI-7399369|ensembl:ENSP00000382376|intact:MINT-134096	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:p29350-3(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:PTP1C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704503|imex:IM-22632-990	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111679(gene)|ensembl:ENST00000399448(transcript)|intact:EBI-78260(isoform-parent)|uniprotkb:P29350-3(isoform-parent)|refseq:NM_080548.4(identity)|entrezgene/locuslink:5777(identity)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	-	comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FES (P07332)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:dOlpiLWoBar/3ryQxTZss7nQqTs9606	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	intact-crc:3123CF4CDDB3F6C4|rigid:ipDvtaGwayDkWR25O5iN15gbQ28	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29372-4	uniprotkb:P46108	intact:EBI-10695618|ensembl:ENSP00000348809	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:p29372-4(display_long)|uniprotkb:MPG(gene name)|psi-mi:MPG(display_short)|uniprotkb:3-alkyladenine DNA glycosylase(gene name synonym)|uniprotkb:3-methyladenine DNA glycosidase(gene name synonym)|uniprotkb:AAG(gene name synonym)|uniprotkb:ADPG(gene name synonym)|uniprotkb:ANPG(gene name synonym)|uniprotkb:MID1(gene name synonym)|uniprotkb:N-methylpurine-DNA glycosylase(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704492|imex:IM-22632-989	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000103152(gene)|ensembl:ENST00000356432(transcript)|intact:EBI-1043398(isoform-parent)|uniprotkb:P29372-4(isoform-parent)|refseq:NM_001015052.2(identity)|entrezgene/locuslink:4350(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), JAK2 (O60674), PTK2 (Q05397), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:aUWGFbqN9ptv1hvAmV6VMBjyaNA9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:F126FE4F36AED1AE|rigid:4AF2n1n2kBBknm6/WpH/lHaezAY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27986-2	uniprotkb:P35568	intact:EBI-9090282|ensembl:ENSP00000338554	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704525|imex:IM-22632-992	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772|refseq:NM_005544.2(identity)|entrezgene/locuslink:3667(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FRK (P42685), FYN (P06241), PTK2 (Q05397), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	intact-crc:697A92671EE19A66|rigid:VQtrgiFLafp63gbkUkDVm2Cv+L8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29350-3	uniprotkb:Q8TAK6	intact:EBI-7399369|ensembl:ENSP00000382376|intact:MINT-134096	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	psi-mi:p29350-3(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:PTP1C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704514|imex:IM-22632-991	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111679(gene)|ensembl:ENST00000399448(transcript)|intact:EBI-78260(isoform-parent)|uniprotkb:P29350-3(isoform-parent)|refseq:NM_080548.4(identity)|entrezgene/locuslink:5777(identity)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	-	comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:dOlpiLWoBar/3ryQxTZss7nQqTs9606	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	intact-crc:89ED294AD0DC55CF|rigid:nh5NO7sbdg2GUQrXmC+X4nGqzVk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:P27986-2	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-9090282|ensembl:ENSP00000338554	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704536|imex:IM-22632-993	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FRK (P42685), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	intact-crc:DEA5598A7850CB16|rigid:5skwRPabOlJ7FcNszPktdg6ROYM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:P27986-2	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-9090282|ensembl:ENSP00000338554	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704547|imex:IM-22632-994	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	intact-crc:4B63C2A3F2587578|rigid:s3tiyX8t06ApN5WdS13y+eNkfcM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:P27986-2	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-9090282|ensembl:ENSP00000338554	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704558|imex:IM-22632-995	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	intact-crc:0A21D17860756E0F|rigid:TiUTBgxDgF+0q1OycYUSE4V6BCA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:P27986-2	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-9090282|ensembl:ENSP00000338554	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704569|imex:IM-22632-996	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	intact-crc:742DE109DCBF36DD|rigid:t3ITtvw+XlbxMKAMMEci+FyvNkg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:P27986-2	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-9090282|ensembl:ENSP00000338554	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704580|imex:IM-22632-997	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	intact-crc:F658A749F911324D|rigid:sMRMCkvSRdlQCrj4a+RhGjFZF7Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:Q9UKG1	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704591|imex:IM-22632-998	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:45E26AD65BA64619|rigid:VKdbDqgrzNfCtF9qZ17lk9oBVR8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TAK6	uniprotkb:P20936-2	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	intact:EBI-10692141|ensembl:ENSP00000411221	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:p20936-2(display_long)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:GAP(gene name synonym)|uniprotkb:RASA(gene name synonym)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:Short(isoform synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704602|imex:IM-22632-999	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	intact:EBI-1026476(isoform-parent)|ensembl:ENSG00000145715(gene)|ensembl:ENST00000456692(transcript)|refseq:NM_022650.2(identity)|entrezgene/locuslink:5921(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FER (P16591), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	rogid:gsn+cRWWTGAXoA4zR9yX9mYLn5s9606	intact-crc:50C8CFB6A274B37F|rigid:ZzhgWs4RXpJWc3k72nFqkMyGzUA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17612	uniprotkb:P46108-2	intact:EBI-476586|uniprotkb:Q32P54|uniprotkb:Q9H2Y0|uniprotkb:Q9NRB4|uniprotkb:Q9NRH9|ensembl:ENSP00000309591|ensembl:ENSP00000499940	intact:EBI-287559|ensembl:ENSP00000381942	psi-mi:kapca_human(display_long)|uniprotkb:PRKACA(gene name)|psi-mi:PRKACA(display_short)|uniprotkb:PKACA(gene name synonym)	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704624|imex:IM-22632-1001	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002721.1|refseq:NP_997401.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|ensembl:ENSG00000072062(gene)|ensembl:ENSG00000288516(gene)|ensembl:ENST00000308677(transcript)|ensembl:ENST00000673550(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:0046827"(positive regulation of protein export from nucleus)|rcsb pdb:5IZJ|rcsb pdb:5J5X|rcsb pdb:5N23|rcsb pdb:5UZK|rcsb pdb:6BYR|rcsb pdb:6BYS|rcsb pdb:6C0U|rcsb pdb:6FRX|rcsb pdb:6NO7|rcsb pdb:6QJ7|rcsb pdb:6WJF|rcsb pdb:6WJG|reactome:R-HSA-111931|reactome:R-HSA-163358|reactome:R-HSA-163560|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-2565942|reactome:R-HSA-380259|rcsb pdb:3MVJ|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3NX8|interpro:IPR044109|rcsb pdb:3OOG|rcsb pdb:3OVV|rcsb pdb:3OWP|rcsb pdb:3OXT|rcsb pdb:3P0M|mint:P17612|rcsb pdb:3POO|rcsb pdb:3VQH|rcsb pdb:4AE6|rcsb pdb:2GU8|rcsb pdb:4AE9|rcsb pdb:4UJ1|rcsb pdb:4UJ2|rcsb pdb:3AGL|rcsb pdb:3AGM|rcsb pdb:3AMA|rcsb pdb:3AMB|rcsb pdb:4UJ9|rcsb pdb:4UJA|rcsb pdb:4UJB|rcsb pdb:4WB5|rcsb pdb:4WB6|rcsb pdb:4WB7|rcsb pdb:3L9L|rcsb pdb:3L9M|rcsb pdb:3L9N|rcsb pdb:4WB8|rcsb pdb:5BX6|rcsb pdb:5BX7|rcsb pdb:5IZF|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|reactome:R-HSA-432040|reactome:R-HSA-4420097|reactome:R-HSA-442720|reactome:R-HSA-512988|reactome:R-HSA-5578775|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5620912|reactome:R-HSA-5621575|reactome:R-HSA-5687128|reactome:R-HSA-8853659|reactome:R-HSA-8854518|reactome:R-HSA-380320|reactome:R-HSA-8963896|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9634600|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|reactome:R-HSA-9010642|refseq:NP_001291278.1|dip:DIP-33878N|entrezgene/locuslink:5566(identity)|refseq:NM_002730.3(identity)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	-	-	isoform-comment:Contains a phosphoserine at position 194.	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:7yhAi67qjSKPIff2dwqjScPXEYM9606	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	intact-crc:40CA0E86F1AD3DAC|rigid:i7WfWW0E9HOfBiK7qn8elkTajSw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:P19419	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-726632|ensembl:ENSP00000247161|ensembl:ENSP00000366182|uniprotkb:O75606|uniprotkb:O95058|uniprotkb:Q969X8|uniprotkb:Q9UJM4|uniprotkb:B2R7H4	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:elk1_human(display_long)|uniprotkb:ELK1(gene name)|psi-mi:ELK1(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704613|imex:IM-22632-1000	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	ensembl:ENSG00000126767(gene)|ensembl:ENST00000247161(transcript)|ensembl:ENST00000376983(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|refseq:NP_001107595.1|refseq:NP_005220.2|refseq:NP_001244097.1|refseq:XP_016884828.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|mint:P19419|rcsb pdb:1DUX|rcsb pdb:5VVT|reactome:R-HSA-198753|reactome:R-HSA-9031628|reactome:R-HSA-9609690|reactome:R-HSA-9634638|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010467"(gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|dip:DIP-36057N|entrezgene/locuslink:2002(identity)|refseq:NM_005229.4(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:fhzXfUkfVKwHJ263gkK8USP+olg9606	intact-crc:4EA8BC15E69FE3CA|rigid:8oc4RqlNYB6tL2MK7eWZRKF7Zps	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q68G74	uniprotkb:P16885	intact:EBI-8474075|intact:MINT-8417689|uniprotkb:E9PGE3|ensembl:ENSP00000294638	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	psi-mi:lhx8_human(display_long)|uniprotkb:LHX8(gene name)|psi-mi:LHX8(display_short)	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704635|imex:IM-22632-1002	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001243043.1|refseq:NP_001001933.1|ensembl:ENSG00000162624(gene)|ensembl:ENST00000294638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001674"(female germ cell nucleus)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007611"(learning or memory)|go:"GO:0008585"(female gonad development)|go:"GO:0021884"(forebrain neuron development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q68G74|entrezgene/locuslink:431707(identity)|refseq:NM_001001933.1(identity)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	-	comment:mint|comment:homomint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813), FRK (P42685), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:L7W2mSN0r9Fl/94L/D2dL5mGHz89606	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	intact-crc:7610479671884E05|rigid:kZu5qBQlrUEZ9yUK/Uy94lItsF0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16885	uniprotkb:P10809	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704646|imex:IM-22632-1003	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N|refseq:NM_199440.1(identity)|entrezgene/locuslink:3329(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606	intact-crc:AC2CDCEA4E978E9E|rigid:Yj/DuYAgyAxO1bGR9fTJ74wj1xA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19419	uniprotkb:P16885	intact:EBI-726632|ensembl:ENSP00000247161|ensembl:ENSP00000366182|uniprotkb:O75606|uniprotkb:O95058|uniprotkb:Q969X8|uniprotkb:Q9UJM4|uniprotkb:B2R7H4	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	psi-mi:elk1_human(display_long)|uniprotkb:ELK1(gene name)|psi-mi:ELK1(display_short)	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704657|imex:IM-22632-1004	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000126767(gene)|ensembl:ENST00000247161(transcript)|ensembl:ENST00000376983(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|refseq:NP_001107595.1|refseq:NP_005220.2|refseq:NP_001244097.1|refseq:XP_016884828.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|mint:P19419|rcsb pdb:1DUX|rcsb pdb:5VVT|reactome:R-HSA-198753|reactome:R-HSA-9031628|reactome:R-HSA-9609690|reactome:R-HSA-9634638|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010467"(gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|dip:DIP-36057N|entrezgene/locuslink:2002(identity)|refseq:NM_005229.4(identity)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:fhzXfUkfVKwHJ263gkK8USP+olg9606	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	intact-crc:83F32E7BC38B4600|rigid:WGA0biGQ89yaUD95BFbcWg88JLk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16885	uniprotkb:Q99645	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	intact:EBI-6677336|ensembl:ENSP00000261172|uniprotkb:A8K3M7|uniprotkb:Q8NEJ5	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:epyc_human(display_long)|uniprotkb:EPYC(gene name)|psi-mi:EPYC(display_short)|uniprotkb:DSPG3(gene name synonym)|uniprotkb:PGLB(gene name synonym)|uniprotkb:SLRR3B(gene name synonym)|uniprotkb:Dermatan sulfate proteoglycan 3(gene name synonym)|uniprotkb:Proteoglycan-Lb(gene name synonym)|uniprotkb:Small chondroitin/dermatan sulfate proteoglycan(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704668|imex:IM-22632-1005	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	ensembl:ENSG00000083782(gene)|ensembl:ENST00000261172(transcript)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0031012"(extracellular matrix)|go:"GO:0060348"(bone development)|go:"GO:0061975"(articular cartilage development)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027217|interpro:IPR032675|interpro:IPR043547|refseq:NP_004941.2|refseq:NM_004950.4(identity)|entrezgene/locuslink:1833(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FRK (P42685), FYN (P06241), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	rogid:1qzc4zJzP7s4IHAGdKeYCcWtEjs9606	intact-crc:AB45BB7F0192C4B7|rigid:VGqIY2bds71xythqOBeq1dbIfLo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	uniprotkb:P12931	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704679|imex:IM-22632-1006	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N|refseq:NM_198291.2(identity)|entrezgene/locuslink:6714(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	intact-crc:021C085081E77E81|rigid:Wn7dCOQmsibkP99UtrupEHsxsqg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NP31	uniprotkb:P11277	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	intact:EBI-514908|uniprotkb:Q15510|uniprotkb:Q15519|ensembl:ENSP00000374370	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:sptb1_human(display_long)|uniprotkb:Beta-I spectrin(gene name synonym)|uniprotkb:SPTB(gene name)|psi-mi:SPTB(display_short)|uniprotkb:SPTB1(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704690|imex:IM-22632-1007	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	refseq:NP_000338.3|refseq:NP_001020029.1|refseq:XP_005268080.1|refseq:XP_016877101.1|refseq:XP_016877103.1|dip:DIP-1021N|ensembl:ENSG00000070182(gene)|ensembl:ENST00000389720(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0008091"(spectrin)|go:"GO:0009986"(cell surface)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031235"(intrinsic component of the cytoplasmic side of the plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051015"(actin filament binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|rcsb pdb:1S35|rcsb pdb:3EDU|rcsb pdb:3F57|rcsb pdb:3KBT|rcsb pdb:3KBU|rcsb pdb:3LBX|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878|entrezgene/locuslink:6710(identity)|refseq:NM_001024858.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), TNK1 (Q13470), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rogid:pMUYFaSR/cKouM4GMi36sGK6aOU9606	intact-crc:33DF9AB49EDE5388|rigid:Jr7HpZGJcHRcOVVjgRxaw/pChMA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14457	uniprotkb:P07947	intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym)	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704712|imex:IM-22632-1009	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1|entrezgene/locuslink:8678(identity)|refseq:NM_003766.3(identity)	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439|refseq:NM_005433.3(identity)|entrezgene/locuslink:7525(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FER (P16591), FES (P07332), FGR (P09769), HCK (P08631), SYK (P43405), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	intact-crc:85553C7C8092699C|rigid:uiWqlqs08ES80MtddGIzjFsHSrg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07947	uniprotkb:Q8TAK6	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	intact:EBI-3867416|uniprotkb:Q7RTS0|ensembl:ENSP00000371785	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:olig1_human(display_long)|uniprotkb:OLIG1(gene name)|psi-mi:OLIG1(display_short)|uniprotkb:BHLHB6(gene name synonym)|uniprotkb:BHLHE21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 6(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704701|imex:IM-22632-1008	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439|refseq:NM_005433.3(identity)|entrezgene/locuslink:7525(identity)	refseq:NP_620450.2|ensembl:ENSG00000184221(gene)|ensembl:ENST00000382348(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032657|interpro:IPR036638|mint:Q8TAK6|refseq:NM_138983.2(identity)|entrezgene/locuslink:116448(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FES (P07332), FGR (P09769), HCK (P08631), PTK2 (Q05397), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	rogid:6zU+GDe1CfmWRzr5E6Bx5NzmLoY9606	intact-crc:37A17B353EF0FDC4|rigid:dgNIcYQENPkBykm+lSHws4I6Oio	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06400	uniprotkb:P62993	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704723|imex:IM-22632-1010	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N|entrezgene/locuslink:5925(identity)|refseq:NM_000321.2(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:xidCNX96KlQzu160polvT61k4Zw9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:7498A2B07010AD01|rigid:KAHMJQFt20oWWb7C6Rd4QnhRCGQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5R372-2	uniprotkb:P06400	intact:EBI-10692254|ensembl:ENSP00000350027	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704734|imex:IM-22632-1011	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N|entrezgene/locuslink:5925(identity)|refseq:NM_000321.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FER (P16591), FGR (P09769), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	rogid:xidCNX96KlQzu160polvT61k4Zw9606	intact-crc:F0A344E24DCFB119|rigid:rItiw7r6VPouBCqUozMppL0AlBc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06241-3	uniprotkb:O15117	intact:EBI-10691738|ensembl:ENSP00000229471	intact:EBI-1753267|uniprotkb:O00359|ensembl:ENSP00000316460|ensembl:ENSP00000426346|uniprotkb:A8K2Y8|uniprotkb:E9PBV9|uniprotkb:Q9NZI9|uniprotkb:B4DLN2	psi-mi:p06241-3(display_long)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:p59-Fyn(gene name synonym)	psi-mi:fyb1_human(display_long)|uniprotkb:FYB1(gene name)|psi-mi:FYB1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLAP130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704745|imex:IM-22632-1012	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-515315(isoform-parent)|uniprotkb:P06241-3(isoform-parent)|ensembl:ENSG00000010810(gene)|ensembl:ENST00000229471(transcript)|refseq:NM_153048.3(identity)|entrezgene/locuslink:2534(identity)	refseq:XP_011512310.1|refseq:XP_011512311.1|refseq:XP_011512312.1|refseq:NP_955367.1|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|mint:O15117|rcsb pdb:1RI9|rcsb pdb:2GTJ|rcsb pdb:2GTO|reactome:R-HSA-202433|reactome:R-HSA-391160|ensembl:ENSG00000082074(gene)|ensembl:ENST00000351578(transcript)|ensembl:ENST00000515010(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|refseq:NP_001230022.1|refseq:NP_001456.3|refseq:XP_006714527.1|refseq:XP_006714528.1|refseq:XP_006714529.1|dip:DIP-42204N|entrezgene/locuslink:2533(identity)|refseq:NM_199335.3(identity)	-	isoform-comment:No experimental confirmation available.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ixo+4kzKOnoEXQlLRJhsg4vrF089606	rogid:ObeGCVefTolMBQGVT/WhglH5F009606	intact-crc:6306CB05AC8E0984|rigid:/44dTxSAzJWhDg5H2Br7/z+VZb8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15117	uniprotkb:P06241	intact:EBI-1753267|uniprotkb:O00359|ensembl:ENSP00000316460|ensembl:ENSP00000426346|uniprotkb:A8K2Y8|uniprotkb:E9PBV9|uniprotkb:Q9NZI9|uniprotkb:B4DLN2	intact:EBI-515315|uniprotkb:Q16248|uniprotkb:Q5R3A6|uniprotkb:Q5R3A7|uniprotkb:Q8N5D7|uniprotkb:B5BU57|intact:EBI-2561531|uniprotkb:E1P557|uniprotkb:H0UI48|ensembl:ENSP00000346671|ensembl:ENSP00000357656	psi-mi:fyb1_human(display_long)|uniprotkb:FYB1(gene name)|psi-mi:FYB1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLAP130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym)	psi-mi:fyn_human(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704756|imex:IM-22632-1013	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011512310.1|refseq:XP_011512311.1|refseq:XP_011512312.1|refseq:NP_955367.1|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|mint:O15117|rcsb pdb:1RI9|rcsb pdb:2GTJ|rcsb pdb:2GTO|reactome:R-HSA-202433|reactome:R-HSA-391160|ensembl:ENSG00000082074(gene)|ensembl:ENST00000351578(transcript)|ensembl:ENST00000515010(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|refseq:NP_001230022.1|refseq:NP_001456.3|refseq:XP_006714527.1|refseq:XP_006714528.1|refseq:XP_006714529.1|dip:DIP-42204N|entrezgene/locuslink:2533(identity)|refseq:NM_199335.3(identity)	refseq:XP_005266947.1|refseq:XP_005266949.1|refseq:NP_002028.1|refseq:NP_694592.1|refseq:NP_694593.1|refseq:XP_016866139.1|refseq:XP_016866140.1|refseq:XP_016866141.1|refseq:XP_016866142.1|refseq:XP_016866143.1|dip:DIP-33876N|ensembl:ENSG00000010810(gene)|ensembl:ENST00000354650(transcript)|ensembl:ENST00000368667(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001764"(neuron migration)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0003015"(heart process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007612"(learning)|go:"GO:0007631"(feeding behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|interpro:IPR036028|interpro:IPR036860|mint:P06241|rcsb pdb:1A0N|rcsb pdb:1AOT|rcsb pdb:1AOU|rcsb pdb:1AVZ|rcsb pdb:1AZG|rcsb pdb:1EFN|rcsb pdb:1FYN|rcsb pdb:1G83|rcsb pdb:1M27|rcsb pdb:1NYF|rcsb pdb:1NYG|rcsb pdb:1SHF|rcsb pdb:1ZBJ|rcsb pdb:2DQ7|rcsb pdb:2MQI|rcsb pdb:2MRJ|rcsb pdb:2MRK|rcsb pdb:3H0F|rcsb pdb:3H0H|rcsb pdb:3H0I|rcsb pdb:3UA6|rcsb pdb:3UA7|rcsb pdb:4D8D|rcsb pdb:4EIK|rcsb pdb:4U17|rcsb pdb:4U1P|rcsb pdb:4ZNX|rcsb pdb:5ZAU|rcsb pdb:6EDF|rcsb pdb:6IPY|rcsb pdb:6IPZ|reactome:R-HSA-114604|reactome:R-HSA-1227986|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5621480|reactome:R-HSA-5621575|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-75892|reactome:R-HSA-8866376|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9706374|reactome:R-HSA-983695|reactome:R-HSA-9670439|entrezgene/locuslink:2534(identity)|refseq:NM_002037.5(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ObeGCVefTolMBQGVT/WhglH5F009606	rogid:GM5wIXENkJgPKwHN+UZBIqUfH6U9606	intact-crc:465C015DF72756EE|rigid:AMYTr7/nqN1KFwwge8ddNFPOyaQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60496	uniprotkb:P06239	intact:EBI-1046024|uniprotkb:Q8N5A4|ensembl:ENSP00000276420	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	psi-mi:dok2_human(display_long)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:DOK2(gene name)|psi-mi:DOK2(display_short)	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704767|imex:IM-22632-1014	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003965.2|ensembl:ENSG00000147443(gene)|ensembl:ENST00000276420(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|rcsb pdb:2D9W|rcsb pdb:2DLW|reactome:R-HSA-210993|reactome:R-HSA-8853659|go:"GO:0007166"(cell surface receptor signaling pathway)|entrezgene/locuslink:9046(identity)|refseq:NM_003974.2(identity)	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374|entrezgene/locuslink:3932(identity)|refseq:NM_001042771.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:gBEpjlq3kc6oYF0uVqPz04hfrHw9606	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	intact-crc:18BDF8CD341FCEBD|rigid:SE5MxwOgB5wzkVaQSvctPJM6fpo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16885	uniprotkb:P04637	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704778|imex:IM-22632-1015	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|refseq:NM_001126112.2(identity)|entrezgene/locuslink:7157(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FRK (P42685), FYN (P06241), SYK (P43405)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	intact-crc:D3FC66AA8FE3969C|rigid:XtXhHedHtoSV13uWpyWyeVaPYAQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75829-2	uniprotkb:Q96JZ2	intact:EBI-10696063|ensembl:ENSP00000388576	intact:EBI-3919324|intact:EBI-28973686|ensembl:ENSP00000482604|ensembl:ENSP00000483354|uniprotkb:B5ME72|uniprotkb:Q6ZNG7	psi-mi:o75829-2(display_long)|uniprotkb:MYETS1(gene name synonym)|uniprotkb:CNMD(gene name)|psi-mi:CNMD(display_short)|uniprotkb:CHMI(gene name synonym)|uniprotkb:Chondromodulin(gene name synonym)|uniprotkb:LECT1(gene name synonym)	psi-mi:hsh2d_human(display_long)|uniprotkb:HSH2D(gene name)|psi-mi:HSH2D(display_short)|uniprotkb:ALX(gene name synonym)|uniprotkb:Adaptor in lymphocytes of unknown function X(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704800|imex:IM-22632-1017	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1220187(isoform-parent)|uniprotkb:O75829-2(isoform-parent)|ensembl:ENSG00000136110(gene)|ensembl:ENST00000448904(transcript)|refseq:NM_001011705.1(identity)|entrezgene/locuslink:11061(identity)	ensembl:ENSP00000483354|ensembl:ENSP00000482604|ensembl:ENSG00000196684(gene)|ensembl:ENST00000613986(transcript)|ensembl:ENST00000616645(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR035047|interpro:IPR036860|rcsb pdb:2CS0|go:"GO:0005737"(cytoplasm)|refseq:NP_116244.1|refseq:NP_001278203.1|refseq:NM_032855.3(identity)|entrezgene/locuslink:84941(identity)	-	isoform-comment:No experimental confirmation available.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:PFYeXYbyIK2gv+GHHQBqfAR2Erg9606	rogid:Y01YjkfU/oOtbz2TdQcnm+lBWhs9606	intact-crc:20451D2A003FD382|rigid:G11YnBLUkEbhF85LbcLa/yN5E08	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95997	uniprotkb:P16885	intact:EBI-2551072|ensembl:ENSP00000344936|ensembl:ENSP00000377536|ensembl:ENSP00000430642	intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3	psi-mi:pttg1_human(display_long)|uniprotkb:EAP1(gene name synonym)|uniprotkb:PTTG(gene name synonym)|uniprotkb:TUTR1(gene name synonym)|uniprotkb:Pituitary tumor-transforming gene 1 protein(gene name synonym)|uniprotkb:Esp1-associated protein(gene name synonym)|uniprotkb:PTTG1(gene name)|psi-mi:PTTG1(display_short)	psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704789|imex:IM-22632-1016	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164611(gene)|ensembl:ENST00000352433(transcript)|ensembl:ENST00000393964(transcript)|ensembl:ENST00000520452(transcript)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007283"(spermatogenesis)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:2000816"(negative regulation of mitotic sister chromatid separation)|interpro:IPR006940(Securin sister-chromatid separation inhibitor)|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-2467813|refseq:NP_004210.1|refseq:NP_001269311.1|refseq:NP_001269312.1|dip:DIP-56460N|entrezgene/locuslink:9232(identity)|refseq:NM_004219.3(identity)	go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|entrezgene/locuslink:5336(identity)|refseq:NM_002661.4(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FES (P07332), PTK2 (Q05397)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:CsVFdecK6rCfJkLuzlnvom1nsB89606	rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606	intact-crc:38239954E5AD22C9|rigid:2h5MK8GaYSgX3seyMhXUwjXt0mI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75604-3	uniprotkb:Q92569	intact:EBI-10696113|ensembl:ENSP00000407842	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:o75604-3(display_long)|uniprotkb:USP2(gene name)|psi-mi:USP2(display_short)|uniprotkb:41 kDa ubiquitin-specific protease(gene name synonym)|uniprotkb:Deubiquitinating enzyme 2(gene name synonym)|uniprotkb:UBP41(gene name synonym)|uniprotkb:Ubiquitin thioesterase 2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 2(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704811|imex:IM-22632-1018	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000036672(gene)|ensembl:ENST00000455332(transcript)|intact:EBI-743272(isoform-parent)|uniprotkb:O75604-3(isoform-parent)|entrezgene/locuslink:9099(identity)|refseq:NM_001243759.1(identity)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	-	isoform-comment:"Ref.7 (AAH41366) sequence is in conflict in position: 10:Y->S."	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FES (P07332), FYN (P06241), JAK2 (O60674), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Ho6ANsxAKd9TWFf8Uw5IRSMMGs49606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:FAD81D6FD36A3838|rigid:ejx2+BgKAcrwsizCIApo7MqJTts	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60880	uniprotkb:P18847	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-712767|ensembl:ENSP00000344352|ensembl:ENSP00000355954|uniprotkb:Q5VTZ2|uniprotkb:Q6ICQ9|uniprotkb:Q7Z566|uniprotkb:Q8WYM6	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:atf3_human(display_long)|uniprotkb:Activating transcription factor 3(gene name synonym)|uniprotkb:ATF3(gene name)|psi-mi:ATF3(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704822|imex:IM-22632-1019	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N|entrezgene/locuslink:4068(identity)|refseq:NM_002351.4(identity)	ensembl:ENSG00000162772(gene)|ensembl:ENST00000341491(transcript)|ensembl:ENST00000366987(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061394"(regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990622"(CHOP-ATF3 complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029812|mint:P18847|reactome:R-HSA-380994|reactome:R-HSA-9633012|reactome:R-HSA-9648895|refseq:NP_001025458.1|refseq:NP_001665.1|refseq:XP_011507881.1|refseq:NP_001035709.1|refseq:NP_001193413.2|refseq:NP_001193415.1|refseq:NP_001193417.2|refseq:XP_005273203.1|dip:DIP-344N|entrezgene/locuslink:467(identity)|refseq:NM_001030287.3(identity)	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BMX (P51813), JAK2 (O60674), PTK2 (Q05397), SYK (P43405), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:4OpideXaQoVFi+x4P6iN5PG6RKY9606	intact-crc:9081AD707E0DFFA9|rigid:VAFRXu0/zESlf5Xh6JnI7SPFAYM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60880	uniprotkb:Q05397	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704833|imex:IM-22632-1020	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N|entrezgene/locuslink:4068(identity)|refseq:NM_002351.4(identity)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422|refseq:NM_153831.3(identity)|entrezgene/locuslink:5747(identity)	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	intact-crc:924D81934A6799B2|rigid:Rb83Qwprac56pswkZs5QzY+2waA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60880	uniprotkb:P16333	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-389883|uniprotkb:B7Z751|ensembl:ENSP00000288986|ensembl:ENSP00000417273|intact:EBI-3448658|uniprotkb:D3DNE3	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:nck1_human(display_long)|uniprotkb:NCK1(gene name)|psi-mi:NCK1(display_short)|uniprotkb:NCK(gene name synonym)|uniprotkb:NCK adaptor protein 1(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-alpha(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704844|imex:IM-22632-1021	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N|entrezgene/locuslink:4068(identity)|refseq:NM_002351.4(identity)	refseq:NP_001278928.1|ensembl:ENSG00000158092(gene)|ensembl:ENST00000288986(transcript)|ensembl:ENST00000481752(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007172"(signal complex assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|refseq:NP_001177725.1|refseq:NP_006144.1|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|mint:P16333|rcsb pdb:2CI8|rcsb pdb:2CI9|rcsb pdb:2CUB|rcsb pdb:2JS0|rcsb pdb:2JS2|rcsb pdb:2JW4|rcsb pdb:5QU1|rcsb pdb:5QU2|rcsb pdb:5QU3|rcsb pdb:5QU4|rcsb pdb:5QU5|rcsb pdb:5QU6|rcsb pdb:5QU7|rcsb pdb:5QU8|rcsb pdb:5QUA|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-373753|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9664422|reactome:R-HSA-983695|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|dip:DIP-639N|entrezgene/locuslink:4690(identity)|refseq:NM_006153.5(identity)	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), LYN (P07948), SRC (P12931)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:UzgLYRQQ9VjN7eKkgn76At/7cSA9606	intact-crc:CA6BC69582991AEF|rigid:2LU/1kY/ivBbNIJ4poGRF9DS45U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60636	uniprotkb:P62993	intact:EBI-3914288|uniprotkb:Q8WU05|uniprotkb:Q5TET2|ensembl:ENSP00000358529|uniprotkb:D6PTH4	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:tsn2_human(display_long)|uniprotkb:TSPAN2(gene name)|psi-mi:TSPAN2(display_short)|uniprotkb:Tetraspan NET-3(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704855|imex:IM-22632-1022	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001295245.1|refseq:NP_005716.2|ensembl:ENSG00000134198(gene)|ensembl:ENST00000369516(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014005"(microglia development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042552"(myelination)|go:"GO:0043209"(myelin sheath)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061564"(axon development)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|refseq:NM_005725.4(identity)|entrezgene/locuslink:10100(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|refseq:NM_002086.4(identity)|entrezgene/locuslink:2885(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631), PTK2 (Q05397), TNK1 (Q13470), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:aAvB/0QxH0/5YF5dkbBh5wpz3uw9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:35AA74E852A7FF6B|rigid:G4awIUPqy2QhVyRj9zHTAk2jFhw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:O60496	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-1046024|uniprotkb:Q8N5A4|ensembl:ENSP00000276420	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:dok2_human(display_long)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:DOK2(gene name)|psi-mi:DOK2(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704877|imex:IM-22632-1024	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_003965.2|ensembl:ENSG00000147443(gene)|ensembl:ENST00000276420(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|rcsb pdb:2D9W|rcsb pdb:2DLW|reactome:R-HSA-210993|reactome:R-HSA-8853659|go:"GO:0007166"(cell surface receptor signaling pathway)|entrezgene/locuslink:9046(identity)|refseq:NM_003974.2(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:gBEpjlq3kc6oYF0uVqPz04hfrHw9606	intact-crc:8342D0F80A5F7E6B|rigid:CY8HkDI6y2dsPrkA/u8DGDiITBA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5R372-2	uniprotkb:O60636	intact:EBI-10692254|ensembl:ENSP00000350027	intact:EBI-3914288|uniprotkb:Q8WU05|uniprotkb:Q5TET2|ensembl:ENSP00000358529|uniprotkb:D6PTH4	psi-mi:q5r372-2(display_long)|uniprotkb:HHL(gene name synonym)|uniprotkb:RABGAP1L(gene name)|psi-mi:RABGAP1L(display_short)|uniprotkb:KIAA0471(gene name synonym)	psi-mi:tsn2_human(display_long)|uniprotkb:TSPAN2(gene name)|psi-mi:TSPAN2(display_short)|uniprotkb:Tetraspan NET-3(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704866|imex:IM-22632-1023	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152061(gene)|ensembl:ENST00000357444(transcript)|intact:EBI-2810417(isoform-parent)|entrezgene/locuslink:9910(identity)|refseq:XM_005245681.1(identity)	refseq:NP_001295245.1|refseq:NP_005716.2|ensembl:ENSG00000134198(gene)|ensembl:ENST00000369516(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014005"(microglia development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042552"(myelination)|go:"GO:0043209"(myelin sheath)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061564"(axon development)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|refseq:NM_005725.4(identity)|entrezgene/locuslink:10100(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FES (P07332)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:QUOT+851a4G+l3pgjKW7xkza9Q09606	rogid:aAvB/0QxH0/5YF5dkbBh5wpz3uw9606	intact-crc:64C5F27E7FABD048|rigid:KWp7TGc59bx/LNcNIiafvHie/H8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108	uniprotkb:O60496	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-1046024|uniprotkb:Q8N5A4|ensembl:ENSP00000276420	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:dok2_human(display_long)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:DOK2(gene name)|psi-mi:DOK2(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704888|imex:IM-22632-1025	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	refseq:NP_003965.2|ensembl:ENSG00000147443(gene)|ensembl:ENST00000276420(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|rcsb pdb:2D9W|rcsb pdb:2DLW|reactome:R-HSA-210993|reactome:R-HSA-8853659|go:"GO:0007166"(cell surface receptor signaling pathway)|entrezgene/locuslink:9046(identity)|refseq:NM_003974.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:gBEpjlq3kc6oYF0uVqPz04hfrHw9606	intact-crc:0FF50E3079D1E061|rigid:bOlLVyMhyXebaRJGsP86+Ia/C2U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46109	uniprotkb:O60496	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	intact:EBI-1046024|uniprotkb:Q8N5A4|ensembl:ENSP00000276420	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:dok2_human(display_long)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:DOK2(gene name)|psi-mi:DOK2(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704899|imex:IM-22632-1026	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|entrezgene/locuslink:1399(identity)|refseq:NM_005207.3(identity)	refseq:NP_003965.2|ensembl:ENSG00000147443(gene)|ensembl:ENST00000276420(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|rcsb pdb:2D9W|rcsb pdb:2DLW|reactome:R-HSA-210993|reactome:R-HSA-8853659|go:"GO:0007166"(cell surface receptor signaling pathway)|entrezgene/locuslink:9046(identity)|refseq:NM_003974.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:gBEpjlq3kc6oYF0uVqPz04hfrHw9606	intact-crc:905B7A8B8D4C402A|rigid:Nuqs70KfBVWr9ICs7aUzcCypyZY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:O60496	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-1046024|uniprotkb:Q8N5A4|ensembl:ENSP00000276420	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:dok2_human(display_long)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:DOK2(gene name)|psi-mi:DOK2(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704910|imex:IM-22632-1027	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	refseq:NP_003965.2|ensembl:ENSG00000147443(gene)|ensembl:ENST00000276420(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|rcsb pdb:2D9W|rcsb pdb:2DLW|reactome:R-HSA-210993|reactome:R-HSA-8853659|go:"GO:0007166"(cell surface receptor signaling pathway)|entrezgene/locuslink:9046(identity)|refseq:NM_003974.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:gBEpjlq3kc6oYF0uVqPz04hfrHw9606	intact-crc:2B07E34CF3273E45|rigid:7K8FYS/QKPqxV1E436fEtAMQBVM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15117	uniprotkb:O43639	intact:EBI-1753267|uniprotkb:O00359|ensembl:ENSP00000316460|ensembl:ENSP00000426346|uniprotkb:A8K2Y8|uniprotkb:E9PBV9|uniprotkb:Q9NZI9|uniprotkb:B4DLN2	intact:EBI-713635|uniprotkb:Q9BWN9|uniprotkb:Q9UIC3|ensembl:ENSP00000233154|ensembl:ENSP00000377018|uniprotkb:D3DVK1	psi-mi:fyb1_human(display_long)|uniprotkb:FYB1(gene name)|psi-mi:FYB1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLAP130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym)	psi-mi:nck2_human(display_long)|uniprotkb:NCK adaptor protein 2(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-beta(gene name synonym)|uniprotkb:NCK2(gene name)|psi-mi:NCK2(display_short)|uniprotkb:GRB4(gene name synonym)|uniprotkb:Growth factor receptor-bound protein 4(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704921|imex:IM-22632-1028	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011512310.1|refseq:XP_011512311.1|refseq:XP_011512312.1|refseq:NP_955367.1|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|mint:O15117|rcsb pdb:1RI9|rcsb pdb:2GTJ|rcsb pdb:2GTO|reactome:R-HSA-202433|reactome:R-HSA-391160|ensembl:ENSG00000082074(gene)|ensembl:ENST00000351578(transcript)|ensembl:ENST00000515010(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|refseq:NP_001230022.1|refseq:NP_001456.3|refseq:XP_006714527.1|refseq:XP_006714528.1|refseq:XP_006714529.1|dip:DIP-42204N|entrezgene/locuslink:2533(identity)|refseq:NM_199335.3(identity)	refseq:XP_006712860.1|refseq:NP_001004720.1|refseq:NP_003572.2|ensembl:ENSG00000071051(gene)|ensembl:ENST00000233154(transcript)|ensembl:ENST00000393349(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0060996"(dendritic spine development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028524|interpro:IPR035559|interpro:IPR035560|interpro:IPR035561|interpro:IPR035883|interpro:IPR036028|interpro:IPR036860|mint:O43639|rcsb pdb:1U5S|rcsb pdb:1WX6|rcsb pdb:1Z3K|rcsb pdb:2B86|rcsb pdb:2CIA|rcsb pdb:2FRW|rcsb pdb:2FRY|rcsb pdb:2JXB|rcsb pdb:4E6R|reactome:R-HSA-186763|reactome:R-HSA-373753|reactome:R-HSA-3928664|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-8985801|reactome:R-HSA-9013420|reactome:R-HSA-9013424|refseq:XP_016860592.1|refseq:XP_016860593.1|refseq:XP_016860594.1|refseq:XP_011510293.1|entrezgene/locuslink:8440(identity)|refseq:NM_001004720.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:ObeGCVefTolMBQGVT/WhglH5F009606	rogid:WV9nJ78Im/ga5KQlRuSN2ODzWpQ9606	intact-crc:CFCC6A5C9B3FA9D0|rigid:/9rvBk8yK2DLnFA19wQhHwm1Yco	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60880	uniprotkb:O43257	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-347522|uniprotkb:Q6IB12|ensembl:ENSP00000304593	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:znhi1_human(display_long)|uniprotkb:Cyclin-G1-binding protein 1(gene name synonym)|uniprotkb:Zinc finger protein subfamily 4A member 1(gene name synonym)|uniprotkb:p18 Hamlet(gene name synonym)|uniprotkb:ZNHIT1(gene name)|psi-mi:ZNHIT1(display_short)|uniprotkb:CGBP1(gene name synonym)|uniprotkb:ZNFN4A1(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704932|imex:IM-22632-1029	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N|entrezgene/locuslink:4068(identity)|refseq:NM_002351.4(identity)	refseq:NP_006340.1|ensembl:ENSG00000106400(gene)|ensembl:ENST00000305105(transcript)|go:"GO:0000812"(Swr1 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031491"(nucleosome binding)|go:"GO:0043486"(histone exchange)|go:"GO:0046872"(metal ion binding)|interpro:IPR007529(Zinc finger, HIT-type)|interpro:IPR039723|mint:O43257|entrezgene/locuslink:10467(identity)|refseq:NM_006349.2(identity)	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), FER (P16591), FGR (P09769), FYN (P06241), HCK (P08631)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:Q7J5KSTTPql/B3mtDg1xvX0EWjw9606	intact-crc:CAE239A7BD35680B|rigid:eIuFL/bOejYNc33Z2igOvRa9oNM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14451	uniprotkb:O43257	intact:EBI-970191|ensembl:ENSP00000310771|ensembl:ENSP00000377759|ensembl:ENSP00000377761|uniprotkb:B2RAV1|uniprotkb:B3KNL0|uniprotkb:B3KWP9|uniprotkb:B7WP75|uniprotkb:Q53YD3|uniprotkb:Q9Y220|uniprotkb:Q92568|uniprotkb:Q96DF9|intact:EBI-1257061|uniprotkb:J3KQM4	intact:EBI-347522|uniprotkb:Q6IB12|ensembl:ENSP00000304593	psi-mi:grb7_human(display_long)|uniprotkb:GRB7(gene name)|psi-mi:GRB7(display_short)|uniprotkb:GRB7 adapter protein(gene name synonym)|uniprotkb:Epidermal growth factor receptor GRB-7(gene name synonym)|uniprotkb:B47(gene name synonym)	psi-mi:znhi1_human(display_long)|uniprotkb:Cyclin-G1-binding protein 1(gene name synonym)|uniprotkb:Zinc finger protein subfamily 4A member 1(gene name synonym)|uniprotkb:p18 Hamlet(gene name synonym)|uniprotkb:ZNHIT1(gene name)|psi-mi:ZNHIT1(display_short)|uniprotkb:CGBP1(gene name synonym)|uniprotkb:ZNFN4A1(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704943|imex:IM-22632-1030	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141738(gene)|ensembl:ENST00000309156(transcript)|ensembl:ENST00000394209(transcript)|ensembl:ENST00000394211(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042995"(cell projection)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035032|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q14451|rcsb pdb:1MW4|rcsb pdb:1WGR|rcsb pdb:2L4K|rcsb pdb:2QMS|rcsb pdb:3PQZ|rcsb pdb:4WWQ|rcsb pdb:4X6S|rcsb pdb:5D0J|rcsb pdb:5EEL|rcsb pdb:5EEQ|rcsb pdb:5TYI|rcsb pdb:5U06|rcsb pdb:5U1Q|go:"GO:0042802"(identical protein binding)|reactome:R-HSA-1306955|reactome:R-HSA-186763|reactome:R-HSA-210993|reactome:R-HSA-8853659|reactome:R-HSA-9696273|reactome:R-HSA-1433557|refseq:NP_001025173.1|refseq:NP_001229371.1|refseq:NP_001229372.1|refseq:NP_005301.2|refseq:NP_001317136.1|dip:DIP-502N|entrezgene/locuslink:2886(identity)|refseq:NM_001030002.2(identity)	refseq:NP_006340.1|ensembl:ENSG00000106400(gene)|ensembl:ENST00000305105(transcript)|go:"GO:0000812"(Swr1 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031491"(nucleosome binding)|go:"GO:0043486"(histone exchange)|go:"GO:0046872"(metal ion binding)|interpro:IPR007529(Zinc finger, HIT-type)|interpro:IPR039723|mint:O43257|entrezgene/locuslink:10467(identity)|refseq:NM_006349.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FRK (P42685), SYK (P43405)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:XViWZjk5YwdZFTG3zs2aNdxeFVQ9606	rogid:Q7J5KSTTPql/B3mtDg1xvX0EWjw9606	intact-crc:F54DFC4E8F20F740|rigid:cVBPfxDQOjlyGhpZiDe7HOkod24	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UN19	uniprotkb:O43257	intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602	intact:EBI-347522|uniprotkb:Q6IB12|ensembl:ENSP00000304593	psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name)	psi-mi:znhi1_human(display_long)|uniprotkb:Cyclin-G1-binding protein 1(gene name synonym)|uniprotkb:Zinc finger protein subfamily 4A member 1(gene name synonym)|uniprotkb:p18 Hamlet(gene name synonym)|uniprotkb:ZNHIT1(gene name)|psi-mi:ZNHIT1(display_short)|uniprotkb:CGBP1(gene name synonym)|uniprotkb:ZNFN4A1(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704954|imex:IM-22632-1031	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695|entrezgene/locuslink:27071(identity)|refseq:NM_014395.2(identity)	refseq:NP_006340.1|ensembl:ENSG00000106400(gene)|ensembl:ENST00000305105(transcript)|go:"GO:0000812"(Swr1 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031491"(nucleosome binding)|go:"GO:0043486"(histone exchange)|go:"GO:0046872"(metal ion binding)|interpro:IPR007529(Zinc finger, HIT-type)|interpro:IPR039723|mint:O43257|entrezgene/locuslink:10467(identity)|refseq:NM_006349.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:YYI49xKbndaB1MfL/QEovp2BF009606	rogid:Q7J5KSTTPql/B3mtDg1xvX0EWjw9606	intact-crc:98693100802A220B|rigid:0zzKsS7/Cf8oVbiqls8xhjPkdno	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15530	uniprotkb:O95704	intact:EBI-717097|uniprotkb:Q8IV52|uniprotkb:Q9BRD5|uniprotkb:Q6FI20|uniprotkb:H0Y4Z0|uniprotkb:Q59EH6|intact:EBI-28968232|ensembl:ENSP00000344220	intact:EBI-286427|uniprotkb:Q9NYX6|uniprotkb:Q9NYX7|uniprotkb:Q08AG4|uniprotkb:Q9NYX8|uniprotkb:B3KQN9|uniprotkb:Q96Q18|uniprotkb:Q9BYD4|ensembl:ENSP00000350171	psi-mi:pdpk1_human(display_long)|uniprotkb:PDPK1(gene name)|psi-mi:PDPK1(display_short)|uniprotkb:PDK1(gene name synonym)	psi-mi:apbb3_human(display_long)|uniprotkb:Protein Fe65-like 2(gene name synonym)|uniprotkb:APBB3(gene name)|psi-mi:APBB3(display_short)|uniprotkb:FE65L2(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704965|imex:IM-22632-1032	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002604.1|refseq:NP_112558.2|ensembl:ENST00000268673|ensembl:ENSP00000268673|ensembl:ENSP00000344220|ensembl:ENST00000441549|ensembl:ENSP00000395357|refseq:NP_001248745.1|ensembl:ENSG00000140992(gene)|ensembl:ENST00000342085(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|rcsb pdb:1H1W|rcsb pdb:1OKY|rcsb pdb:1OKZ|rcsb pdb:1UU3|rcsb pdb:1UU7|rcsb pdb:1UU8|rcsb pdb:1UU9|rcsb pdb:1UVR|rcsb pdb:1W1G|rcsb pdb:1W1H|rcsb pdb:1Z5M|rcsb pdb:2BIY|rcsb pdb:2PE0|rcsb pdb:2PE1|rcsb pdb:2PE2|rcsb pdb:2R7B|rcsb pdb:2VKI|rcsb pdb:2XCH|rcsb pdb:2XCK|rcsb pdb:3H9O|rcsb pdb:3HRC|rcsb pdb:3HRF|rcsb pdb:3ION|rcsb pdb:3IOP|rcsb pdb:3NAX|rcsb pdb:3NAY|rcsb pdb:3NUN|rcsb pdb:3NUS|rcsb pdb:3NUU|rcsb pdb:3NUY|rcsb pdb:3ORX|rcsb pdb:3ORZ|rcsb pdb:3OTU|rcsb pdb:1W1D|rcsb pdb:3PWY|rcsb pdb:3QC4|rcsb pdb:3QCQ|rcsb pdb:3QCS|rcsb pdb:3QCX|rcsb pdb:3QCY|rcsb pdb:3QD0|rcsb pdb:3QD3|rcsb pdb:3QD4|rcsb pdb:3RCJ|rcsb pdb:3RWP|rcsb pdb:3RWQ|rcsb pdb:3SC1|rcsb pdb:4A06|rcsb pdb:4A07|rcsb pdb:4AW0|rcsb pdb:4AW1|rcsb pdb:4CT1|rcsb pdb:4CT2|rcsb pdb:4RQK|rcsb pdb:4RQV|rcsb pdb:4RRV|rcsb pdb:4XX9|rcsb pdb:5ACK|rcsb pdb:5HKM|rcsb pdb:5HNG|rcsb pdb:5HO7|rcsb pdb:5HO8|rcsb pdb:5LVL|rcsb pdb:5LVM|rcsb pdb:5LVN|rcsb pdb:5LVO|rcsb pdb:5LVP|rcsb pdb:5MRD|rcsb pdb:6WJQ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-165158|reactome:R-HSA-202424|reactome:R-HSA-2730905|reactome:R-HSA-2871837|reactome:R-HSA-354192|reactome:R-HSA-389357|reactome:R-HSA-392451|reactome:R-HSA-444257|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5625740|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-9634635|dip:DIP-38372N|entrezgene/locuslink:5170(identity)|refseq:NM_031268.5(identity)	refseq:NP_006042.3|refseq:NP_573418.2|refseq:NP_573419.2|refseq:NP_573420.2|ensembl:ENSG00000113108(gene)|ensembl:ENST00000357560(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036020|interpro:IPR039576|rcsb pdb:2DYQ|rcsb pdb:2YSC|entrezgene/locuslink:10307(identity)|refseq:NM_133173.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:1Uf7b8GptL7XBfEZm43zB3ho6ZQ9606	rogid:U1jEo7ZPG53cA/BcJs/BMGo/vWE9606	intact-crc:6CF0ACC38A5C2D75|rigid:G937Pzr+FTvLKzQuJkstSTpSFlY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15530	uniprotkb:P41240	intact:EBI-717097|uniprotkb:Q8IV52|uniprotkb:Q9BRD5|uniprotkb:Q6FI20|uniprotkb:H0Y4Z0|uniprotkb:Q59EH6|intact:EBI-28968232|ensembl:ENSP00000344220	intact:EBI-1380630|uniprotkb:Q2M3N2|uniprotkb:Q6FGZ6|ensembl:ENSP00000220003|ensembl:ENSP00000414764|ensembl:ENSP00000454906	psi-mi:pdpk1_human(display_long)|uniprotkb:PDPK1(gene name)|psi-mi:PDPK1(display_short)|uniprotkb:PDK1(gene name synonym)	psi-mi:csk_human(display_long)|uniprotkb:CSK(gene name)|psi-mi:CSK(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase CYL(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704976|imex:IM-22632-1033	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002604.1|refseq:NP_112558.2|ensembl:ENST00000268673|ensembl:ENSP00000268673|ensembl:ENSP00000344220|ensembl:ENST00000441549|ensembl:ENSP00000395357|refseq:NP_001248745.1|ensembl:ENSG00000140992(gene)|ensembl:ENST00000342085(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|rcsb pdb:1H1W|rcsb pdb:1OKY|rcsb pdb:1OKZ|rcsb pdb:1UU3|rcsb pdb:1UU7|rcsb pdb:1UU8|rcsb pdb:1UU9|rcsb pdb:1UVR|rcsb pdb:1W1G|rcsb pdb:1W1H|rcsb pdb:1Z5M|rcsb pdb:2BIY|rcsb pdb:2PE0|rcsb pdb:2PE1|rcsb pdb:2PE2|rcsb pdb:2R7B|rcsb pdb:2VKI|rcsb pdb:2XCH|rcsb pdb:2XCK|rcsb pdb:3H9O|rcsb pdb:3HRC|rcsb pdb:3HRF|rcsb pdb:3ION|rcsb pdb:3IOP|rcsb pdb:3NAX|rcsb pdb:3NAY|rcsb pdb:3NUN|rcsb pdb:3NUS|rcsb pdb:3NUU|rcsb pdb:3NUY|rcsb pdb:3ORX|rcsb pdb:3ORZ|rcsb pdb:3OTU|rcsb pdb:1W1D|rcsb pdb:3PWY|rcsb pdb:3QC4|rcsb pdb:3QCQ|rcsb pdb:3QCS|rcsb pdb:3QCX|rcsb pdb:3QCY|rcsb pdb:3QD0|rcsb pdb:3QD3|rcsb pdb:3QD4|rcsb pdb:3RCJ|rcsb pdb:3RWP|rcsb pdb:3RWQ|rcsb pdb:3SC1|rcsb pdb:4A06|rcsb pdb:4A07|rcsb pdb:4AW0|rcsb pdb:4AW1|rcsb pdb:4CT1|rcsb pdb:4CT2|rcsb pdb:4RQK|rcsb pdb:4RQV|rcsb pdb:4RRV|rcsb pdb:4XX9|rcsb pdb:5ACK|rcsb pdb:5HKM|rcsb pdb:5HNG|rcsb pdb:5HO7|rcsb pdb:5HO8|rcsb pdb:5LVL|rcsb pdb:5LVM|rcsb pdb:5LVN|rcsb pdb:5LVO|rcsb pdb:5LVP|rcsb pdb:5MRD|rcsb pdb:6WJQ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-165158|reactome:R-HSA-202424|reactome:R-HSA-2730905|reactome:R-HSA-2871837|reactome:R-HSA-354192|reactome:R-HSA-389357|reactome:R-HSA-392451|reactome:R-HSA-444257|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5625740|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-9634635|dip:DIP-38372N|entrezgene/locuslink:5170(identity)|refseq:NM_031268.5(identity)	refseq:NP_001120662.1|refseq:NP_004374.1|refseq:XP_005254222.1|refseq:XP_016877414.1|ensembl:ENSG00000103653(gene)|ensembl:ENST00000220003(transcript)|ensembl:ENST00000439220(transcript)|ensembl:ENST00000567571(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|mint:P41240|rcsb pdb:1BYG|rcsb pdb:1CSK|rcsb pdb:3D7T|rcsb pdb:3D7U|rcsb pdb:3EAC|rcsb pdb:3EAZ|reactome:R-HSA-180292|reactome:R-HSA-202427|reactome:R-HSA-354192|reactome:R-HSA-389948|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9013407|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9706369|refseq:NM_001127190.1(identity)|entrezgene/locuslink:1445(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:1Uf7b8GptL7XBfEZm43zB3ho6ZQ9606	rogid:9n6rgUUGjJ+e0fMPrB4A7JGyZqE9606	intact-crc:92FDBD0928B2B42E|rigid:wkU7z4mVATH3uQntxT4s2nL7aHo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46109	uniprotkb:O15524	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	intact:EBI-968198|ensembl:ENSP00000329418|ensembl:ENSP00000496577|uniprotkb:O15097|uniprotkb:Q9NSA7	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:socs1_human(display_long)|uniprotkb:SOCS1(gene name)|psi-mi:SOCS1(display_short)|uniprotkb:SSI1(gene name synonym)|uniprotkb:TIP3(gene name synonym)|uniprotkb:JAK-binding protein(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 1(gene name synonym)|uniprotkb:Tec-interacting protein 3(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704998|imex:IM-22632-1035	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|entrezgene/locuslink:1399(identity)|refseq:NM_005207.3(identity)	go:"GO:0043377"(negative regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010533"(regulation of activation of Janus kinase activity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR028411|interpro:IPR035861|interpro:IPR036036|interpro:IPR036860|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|mint:O15524|reactome:R-HSA-1266695|reactome:R-HSA-1433559|reactome:R-HSA-166058|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|ensembl:ENSG00000185338(gene)|ensembl:ENST00000332029(transcript)|ensembl:ENST00000644787(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|refseq:NP_003736.1|dip:DIP-29662N|entrezgene/locuslink:8651(identity)|refseq:NM_003745.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:Ybb6XvshFQp4GUNEiBZ41ff/H8I9606	intact-crc:1348C65FBDC3AB1E|rigid:ZWLwANzLCSZ80ZhC/Y/hWE4cjSQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27986-2	uniprotkb:O15524	intact:EBI-9090282|ensembl:ENSP00000338554	intact:EBI-968198|ensembl:ENSP00000329418|ensembl:ENSP00000496577|uniprotkb:O15097|uniprotkb:Q9NSA7	psi-mi:p27986-2(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:AS53(isoform synonym)	psi-mi:socs1_human(display_long)|uniprotkb:SOCS1(gene name)|psi-mi:SOCS1(display_short)|uniprotkb:SSI1(gene name synonym)|uniprotkb:TIP3(gene name synonym)|uniprotkb:JAK-binding protein(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 1(gene name synonym)|uniprotkb:Tec-interacting protein 3(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10704987|imex:IM-22632-1034	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145675(gene)|ensembl:ENST00000336483(transcript)|intact:EBI-79464(isoform-parent)|uniprotkb:P27986-2(isoform-parent)|entrezgene/locuslink:5295(identity)|refseq:NM_181504.3(identity)	go:"GO:0043377"(negative regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010533"(regulation of activation of Janus kinase activity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR028411|interpro:IPR035861|interpro:IPR036036|interpro:IPR036860|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|mint:O15524|reactome:R-HSA-1266695|reactome:R-HSA-1433559|reactome:R-HSA-166058|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|ensembl:ENSG00000185338(gene)|ensembl:ENST00000332029(transcript)|ensembl:ENST00000644787(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|refseq:NP_003736.1|dip:DIP-29662N|entrezgene/locuslink:8651(identity)|refseq:NM_003745.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:QtFCNbZABbNcR8Cd7rk+QMroFYM9606	rogid:Ybb6XvshFQp4GUNEiBZ41ff/H8I9606	intact-crc:106A37D1A66FFC9E|rigid:YLiHNfo9dMsHp4TSjc5o3Mpvrqc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:O15524	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-968198|ensembl:ENSP00000329418|ensembl:ENSP00000496577|uniprotkb:O15097|uniprotkb:Q9NSA7	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:socs1_human(display_long)|uniprotkb:SOCS1(gene name)|psi-mi:SOCS1(display_short)|uniprotkb:SSI1(gene name synonym)|uniprotkb:TIP3(gene name synonym)|uniprotkb:JAK-binding protein(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 1(gene name synonym)|uniprotkb:Tec-interacting protein 3(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705009|imex:IM-22632-1036	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	go:"GO:0043377"(negative regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010533"(regulation of activation of Janus kinase activity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR028411|interpro:IPR035861|interpro:IPR036036|interpro:IPR036860|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|mint:O15524|reactome:R-HSA-1266695|reactome:R-HSA-1433559|reactome:R-HSA-166058|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|ensembl:ENSG00000185338(gene)|ensembl:ENST00000332029(transcript)|ensembl:ENST00000644787(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|refseq:NP_003736.1|dip:DIP-29662N|entrezgene/locuslink:8651(identity)|refseq:NM_003745.1(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:Ybb6XvshFQp4GUNEiBZ41ff/H8I9606	intact-crc:EA09E8A59FB2DCC5|rigid:U9EdHuhfDXQEYU3QUEbROzECAKQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:O15273	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-954089|ensembl:ENSP00000312624|uniprotkb:Q96L27	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:telt_human(display_long)|uniprotkb:Titin cap protein(gene name synonym)|uniprotkb:TCAP(gene name)|psi-mi:TCAP(display_short)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705020|imex:IM-22632-1037	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	ensembl:ENSG00000173991(gene)|ensembl:ENST00000309889(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005829"(cytosol)|go:"GO:0007512"(adult heart development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0031432"(titin binding)|go:"GO:0031674"(I band)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036122"(BMP binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051373"(FATZ binding)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070080"(titin Z domain binding)|interpro:IPR015667(Telethonin)|interpro:IPR023111|mint:O15273|rcsb pdb:1YA5|rcsb pdb:2F8V|reactome:R-HSA-390522|refseq:NP_003664.1|dip:DIP-35730N|entrezgene/locuslink:8557(identity)|refseq:NM_003673.3(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:2Dfb7mWswRzoRh/YwYCWfzfTEu09606	intact-crc:B03DAFE2FF214CCE|rigid:WqMVsnfzi5Bgn3g2IYjW23UGFFY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13387	uniprotkb:O15205	intact:EBI-722813|uniprotkb:Q96G62|uniprotkb:Q99771|uniprotkb:Q9NZ59|uniprotkb:Q9UKQ4|ensembl:ENSP00000330572	intact:EBI-6657186|ensembl:ENSP00000366249|ensembl:ENSP00000373039|ensembl:ENSP00000396152|ensembl:ENSP00000410416|uniprotkb:Q96EC7|uniprotkb:Q5STL2|uniprotkb:B0UZT6|uniprotkb:Q5SUK2	psi-mi:jip2_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:MAPK8IP2(gene name)|psi-mi:MAPK8IP2(display_short)|uniprotkb:IB2(gene name synonym)|uniprotkb:JIP2(gene name synonym)|uniprotkb:PRKM8IPL(gene name synonym)	psi-mi:ubd_human(display_long)|uniprotkb:UBD(gene name)|psi-mi:UBD(display_short)|uniprotkb:Diubiquitin(gene name synonym)|uniprotkb:FAT10(gene name synonym)|uniprotkb:Ubiquitin-like protein FAT10(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705031|imex:IM-22632-1038	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036456.1|ensembl:ENSG00000008735(gene)|ensembl:ENST00000329492(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007254"(JNK cascade)|go:"GO:0007617"(mating behavior)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q13387|entrezgene/locuslink:23542(identity)|refseq:NM_012324.4(identity)	ensembl:ENSG00000231968(gene)|ensembl:ENST00000377050(transcript)|ensembl:ENST00000383547(transcript)|ensembl:ENST00000421519(transcript)|ensembl:ENST00000432676(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016235"(aggresome)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|ensembl:ENSG00000206468(gene)|ensembl:ENSG00000213886(gene)|ensembl:ENSG00000228913(gene)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0070628"(proteasome binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|interpro:IPR042969|rcsb pdb:2MBE|rcsb pdb:6GF1|rcsb pdb:6GF2|reactome:R-HSA-8951664|refseq:NP_006389.2|entrezgene/locuslink:10537(identity)|refseq:NM_006398.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), JAK2 (O60674), PTK2 (Q05397), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:3Pa/cmqUprk3CMFdzukzIo63hH89606	rogid:ySUgohBHmcPaAaD/l21zkQ3+MPI9606	intact-crc:9D14792E4417183D|rigid:rLhCDLAx9wPuip0MInXtSn5dBug	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46109	uniprotkb:O15033	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	intact:EBI-2831131|uniprotkb:Q7LDY1|uniprotkb:Q8IYY9|uniprotkb:B4E2C7|ensembl:ENSP00000348714|ensembl:ENSP00000505623	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:arel1_human(display_long)|uniprotkb:AREL1(gene name)|psi-mi:AREL1(display_short)|uniprotkb:KIAA0317(gene name synonym)|uniprotkb:Apoptosis-resistant HECT-type E3 ubiquitin transferase 1(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705042|imex:IM-22632-1039	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|entrezgene/locuslink:1399(identity)|refseq:NM_005207.3(identity)	refseq:XP_011535717.1|refseq:NP_001034568.1|ensembl:ENSG00000119682(gene)|ensembl:ENST00000356357(transcript)|ensembl:ENST00000681599(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000569(HECT)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR035983|rcsb pdb:6JX5|rcsb pdb:6LOH|reactome:R-HSA-983168|entrezgene/locuslink:9870(identity)|refseq:NM_001039479.1(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:zp9Zpv/naHGK4L5oA49hviZs72Y9606	intact-crc:57638220A987F16B|rigid:wigG9ea28WHrU6ExytbqEhqTSNE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14669	uniprotkb:P46108	intact:EBI-9824765|uniprotkb:Q6IBF8|ensembl:ENSP00000246794	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:tmg2_human(display_long)|uniprotkb:PRRG2(gene name)|psi-mi:PRRG2(display_short)|uniprotkb:PRGP2(gene name synonym)|uniprotkb:TMG2(gene name synonym)|uniprotkb:Proline-rich gamma-carboxyglutamic acid protein 2(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705064|imex:IM-22632-1041	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000942.1|refseq:XP_006723349.1|ensembl:ENSP00000246794|dip:DIP-60947N|ensembl:ENSG00000126460(gene)|ensembl:ENST00000246794(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR035972|entrezgene/locuslink:5639(identity)|refseq:NM_000951.2(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|refseq:NM_016823.3(identity)|entrezgene/locuslink:1398(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FES (P07332), JAK2 (O60674)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:wkBqF06lHxIu/lz5GFK0tj9bPtU9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:F55FAC86C3D1ED96|rigid:rCwMhwjppM8rtdIAordjX9+oOrw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14796	uniprotkb:Q53HF2	intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906	intact:EBI-877761	psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym)	psi-mi:q53hf2_human(display_long)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705053|imex:IM-22632-1040	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933|entrezgene/locuslink:117157(identity)|refseq:NM_053282.4(identity)	go:"GO:0005524"(ATP binding)|refseq:NP_006588.1|refseq:NP_694881.1|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR043129|refseq:NM_153201.3(identity)|entrezgene/locuslink:3303(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), BLK (P51451), BMX (P51813), FGR (P09769), FYN (P06241), HCK (P08631), SRC (P12931), TNK1 (Q13470), YES1 (P07947)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606	rogid:m6Qk8kbAwVk7YILzmsVDpzKHUvE9606	intact-crc:85F7915F35A74E4E|rigid:4XU6qktSmuvuPHcfeP+LX8pbcUQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:O14544	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-3929549|uniprotkb:Q8WUM3|ensembl:ENSP00000381034|ensembl:ENSP00000463395	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:socs6_human(display_long)|uniprotkb:SOCS6(gene name)|psi-mi:SOCS6(display_short)|uniprotkb:CIS4(gene name synonym)|uniprotkb:SOCS4(gene name synonym)|uniprotkb:Cytokine-inducible SH2 protein 4(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 4(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705075|imex:IM-22632-1042	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	interpro:IPR037345|mint:O14544|rcsb pdb:2VIF|reactome:R-HSA-1433559|reactome:R-HSA-8951664|reactome:R-HSA-9706369|interpro:IPR036860|ensembl:ENSG00000170677(gene)|ensembl:ENST00000397942(transcript)|ensembl:ENST00000582322(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028421|interpro:IPR035865|interpro:IPR036036|refseq:NP_004223.2|refseq:XP_005266840.1|refseq:XP_016881575.1|refseq:XP_016881576.1|refseq:NM_004232.3(identity)|entrezgene/locuslink:9306(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:O++hp+HHhT2m2QNupHdNfK5DBqQ9606	intact-crc:A9BBF48159D6E64E|rigid:zPsHf9WDLt3pTBrqummdh6Z3LlA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:O14544	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-3929549|uniprotkb:Q8WUM3|ensembl:ENSP00000381034|ensembl:ENSP00000463395	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:socs6_human(display_long)|uniprotkb:SOCS6(gene name)|psi-mi:SOCS6(display_short)|uniprotkb:CIS4(gene name synonym)|uniprotkb:SOCS4(gene name synonym)|uniprotkb:Cytokine-inducible SH2 protein 4(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 4(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705086|imex:IM-22632-1043	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	interpro:IPR037345|mint:O14544|rcsb pdb:2VIF|reactome:R-HSA-1433559|reactome:R-HSA-8951664|reactome:R-HSA-9706369|interpro:IPR036860|ensembl:ENSG00000170677(gene)|ensembl:ENST00000397942(transcript)|ensembl:ENST00000582322(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028421|interpro:IPR035865|interpro:IPR036036|refseq:NP_004223.2|refseq:XP_005266840.1|refseq:XP_016881575.1|refseq:XP_016881576.1|refseq:NM_004232.3(identity)|entrezgene/locuslink:9306(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:O++hp+HHhT2m2QNupHdNfK5DBqQ9606	intact-crc:5DEC27E3C9D5826D|rigid:mnfXsSJa6Uh2DAJC2qDtdM6VOFE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14544	uniprotkb:Q9UKG1	intact:EBI-3929549|uniprotkb:Q8WUM3|ensembl:ENSP00000381034|ensembl:ENSP00000463395	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	psi-mi:socs6_human(display_long)|uniprotkb:SOCS6(gene name)|psi-mi:SOCS6(display_short)|uniprotkb:CIS4(gene name synonym)|uniprotkb:SOCS4(gene name synonym)|uniprotkb:Cytokine-inducible SH2 protein 4(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 4(gene name synonym)	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705097|imex:IM-22632-1044	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR037345|mint:O14544|rcsb pdb:2VIF|reactome:R-HSA-1433559|reactome:R-HSA-8951664|reactome:R-HSA-9706369|interpro:IPR036860|ensembl:ENSG00000170677(gene)|ensembl:ENST00000397942(transcript)|ensembl:ENST00000582322(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028421|interpro:IPR035865|interpro:IPR036036|refseq:NP_004223.2|refseq:XP_005266840.1|refseq:XP_016881575.1|refseq:XP_016881576.1|refseq:NM_004232.3(identity)|entrezgene/locuslink:9306(identity)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|entrezgene/locuslink:26060(identity)|refseq:NM_012096.2(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:O++hp+HHhT2m2QNupHdNfK5DBqQ9606	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	intact-crc:95D867B4B9579DE3|rigid:ORjmfoXBctm9R/40GtD+maSgH0E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TBB1	uniprotkb:O14544	intact:EBI-739832|uniprotkb:Q4W5K7|uniprotkb:Q8N4C2|uniprotkb:Q96MJ7|uniprotkb:Q9BY20|ensembl:ENSP00000263925	intact:EBI-3929549|uniprotkb:Q8WUM3|ensembl:ENSP00000381034|ensembl:ENSP00000463395	psi-mi:lnx1_human(display_long)|uniprotkb:LNX1(gene name)|psi-mi:LNX1(display_short)|uniprotkb:LNX(gene name synonym)|uniprotkb:Numb-binding protein 1(gene name synonym)|uniprotkb:Ligand of Numb-protein X 1(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 2(gene name synonym)|uniprotkb:PDZRN2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase LNX(gene name synonym)|uniprotkb:UNQ574/PRO1136(orf name)	psi-mi:socs6_human(display_long)|uniprotkb:SOCS6(gene name)|psi-mi:SOCS6(display_short)|uniprotkb:CIS4(gene name synonym)|uniprotkb:SOCS4(gene name synonym)|uniprotkb:Cytokine-inducible SH2 protein 4(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 4(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705108|imex:IM-22632-1045	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119800.1|refseq:NP_116011.2|refseq:XP_005265842.1|refseq:XP_016864265.1|ensembl:ENSG00000072201(gene)|ensembl:ENST00000263925(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8TBB1|rcsb pdb:3B76|rcsb pdb:5H7R|rcsb pdb:5H7S|reactome:R-HSA-983168|refseq:NM_001126328.2(identity)|entrezgene/locuslink:84708(identity)	interpro:IPR037345|mint:O14544|rcsb pdb:2VIF|reactome:R-HSA-1433559|reactome:R-HSA-8951664|reactome:R-HSA-9706369|interpro:IPR036860|ensembl:ENSG00000170677(gene)|ensembl:ENST00000397942(transcript)|ensembl:ENST00000582322(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028421|interpro:IPR035865|interpro:IPR036036|refseq:NP_004223.2|refseq:XP_005266840.1|refseq:XP_016881575.1|refseq:XP_016881576.1|refseq:NM_004232.3(identity)|entrezgene/locuslink:9306(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: BMX (P51813), FES (P07332), FRK (P42685), FYN (P06241), PTK2 (Q05397), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:tWvePnVxh9yxWl8nQd3KZhCSKKo9606	rogid:O++hp+HHhT2m2QNupHdNfK5DBqQ9606	intact-crc:AC2294A2E75AA77C|rigid:sYlGSqRZXHeSTvEdLNLxwGtpSbI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14543	uniprotkb:Q9NP31	intact:EBI-714146|uniprotkb:O14509|ensembl:ENSP00000330341	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:socs3_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 3(gene name synonym)|uniprotkb:SOCS3(gene name)|psi-mi:SOCS3(display_short)|uniprotkb:CIS3(gene name synonym)|uniprotkb:SSI3(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705119|imex:IM-22632-1046	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O14543|reactome:R-HSA-1059683|reactome:R-HSA-2586552|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8849474|reactome:R-HSA-8939242|reactome:R-HSA-8951664|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|go:"GO:0050728"(negative regulation of inflammatory response)|ensembl:ENSG00000184557(gene)|ensembl:ENST00000330871(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|refseq:NP_003946.3|entrezgene/locuslink:9021(identity)|refseq:NM_003955.4(identity)	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)|refseq:NM_001161444.1(identity)|entrezgene/locuslink:9047(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:8HnU9EL52BGdud2WFZwYsv5R22I9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	intact-crc:AF1E930298822B2F|rigid:JZXoO/O0u4W5qzJ2wzC0Mtxv8KM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z7G1	uniprotkb:O00746	intact:EBI-7878194|intact:MINT-1493840|uniprotkb:Q9P2U9|uniprotkb:Q05C27|ensembl:ENSP00000226951	intact:EBI-744871|uniprotkb:Q5U0M9|ensembl:ENSP00000219479|uniprotkb:A2IDD0	psi-mi:clnk_human(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:CLNK(gene name)|psi-mi:CLNK(display_short)|uniprotkb:MIST(gene name synonym)	psi-mi:ndkm_human(display_long)|uniprotkb:nm23-H4(gene name synonym)|uniprotkb:Nucleoside diphosphate kinase D(gene name synonym)|uniprotkb:NME4(gene name)|psi-mi:NME4(display_short)|uniprotkb:NM23D(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705130|imex:IM-22632-1047	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_443196.2|ensembl:ENSG00000109684(gene)|ensembl:ENST00000226951(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|entrezgene/locuslink:116449(identity)|refseq:NM_052964.2(identity)	refseq:NP_001273362.1|refseq:NP_001273364.1|refseq:NP_001273365.1|refseq:NP_001273367.1|refseq:NP_001273368.1|refseq:NP_001273369.1|refseq:NP_005000.1|ensembl:ENSG00000103202(gene)|ensembl:ENST00000219479(transcript)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006869"(lipid transport)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:O00746|rcsb pdb:1EHW|reactome:R-HSA-499943|refseq:NM_005009.2(identity)|entrezgene/locuslink:4833(identity)	-	function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:/7UA+xjzgD4LUAzAQwwaX3iS7eo9606	rogid:ybA9I8oT+oz1iuGLHT7WR1SAaKY9606	intact-crc:BBE57434650C2DF4|rigid:LtYOzRYMEpdH6/hIZ9cYjFWUrMw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:O00459	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705141|imex:IM-22632-1048	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|refseq:NM_005188.3(identity)|entrezgene/locuslink:867(identity)	ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409|entrezgene/locuslink:5296(identity)|refseq:NM_005027.3(identity)	-	-	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/19	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606	intact-crc:3EE8B25738AAB5AD|rigid:EQkrvLH2YoboJ8PKT7kULfTFGnc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46108-2	uniprotkb:O00459	intact:EBI-287559|ensembl:ENSP00000381942	intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254	psi-mi:p46108-2(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705152|imex:IM-22632-1049	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|uniprotkb:P46108-2(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000398970(transcript)|refseq:NM_005206.4(identity)|entrezgene/locuslink:1398(identity)	ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409|entrezgene/locuslink:5296(identity)|refseq:NM_005027.3(identity)	-	isoform-comment:Contains a phosphoserine at position 194.	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:DTGbc/nBN3HmEFiyiGlWpf80GXo9606	rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606	intact-crc:66F21E581B87EFAA|rigid:VDV+yTCMN0vfoJqUyLy6JI8GGCk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q18PE1	intact:EBI-10696506	intact:EBI-3046647|ensembl:ENSP00000344432|uniprotkb:E9PB56|uniprotkb:Q8NBC1|uniprotkb:Q86XG5|uniprotkb:Q8N2J3|uniprotkb:A2A499|uniprotkb:Q6P6A6|uniprotkb:A2RRD4	-	psi-mi:dok7_human(display_long)|uniprotkb:DOK7(gene name)|psi-mi:DOK7(display_short)|uniprotkb:C4orf25(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 7(gene name synonym)	psi-mi:mpzl1(display_short)|psi-mi:EBI-10696506(display_long)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705163|imex:IM-22632-1050	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000175920(gene)|ensembl:ENST00000340083(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045202"(synapse)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037746|interpro:IPR037747|interpro:IPR037748|refseq:NP_001288000.1|refseq:NP_001158145.1|refseq:NP_775931.3|refseq:NP_001243825.1|refseq:NM_173660.4(identity)|entrezgene/locuslink:285489(identity)	entrezgene/locuslink:9019(identity)|refseq:NM_003953.5(identity)	-	-	no-uniprot-update:	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684), FYN (P06241), TNK1 (Q13470)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:RNSUGsyQVitqfrm+mTmzf0fZHR49606	rogid:1GWPVDd8qhs7qSMespdwAU9jUxY9606	intact-crc:0B986550DEEABE3A|rigid:iIvEkTklatg0dBTXgfFbByWdLQ8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92569	intact:EBI-10696575	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	-	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:znf767(display_short)|psi-mi:EBI-10696575(display_long)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705174|imex:IM-22632-1051	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|entrezgene/locuslink:8503(identity)|refseq:NM_001114172.1(identity)	entrezgene/locuslink:79970(identity)|refseq:XM_005249956.1(identity)	-	-	no-uniprot-update:	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:bmyvECfdUfkpegeqBiK1W412c5s9606	intact-crc:7D2A62891B2BFBE2|rigid:zBLBhiA3EbMsU1GvRVot+/BSx3o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96JZ2	intact:EBI-10696539	intact:EBI-3919324|intact:EBI-28973686|ensembl:ENSP00000482604|ensembl:ENSP00000483354|uniprotkb:B5ME72|uniprotkb:Q6ZNG7	-	psi-mi:hsh2d_human(display_long)|uniprotkb:HSH2D(gene name)|psi-mi:HSH2D(display_short)|uniprotkb:ALX(gene name synonym)|uniprotkb:Adaptor in lymphocytes of unknown function X(gene name synonym)	psi-mi:ppapdc2(display_short)|psi-mi:EBI-10696539(display_long)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705185|imex:IM-22632-1052	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000483354|ensembl:ENSP00000482604|ensembl:ENSG00000196684(gene)|ensembl:ENST00000613986(transcript)|ensembl:ENST00000616645(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR035047|interpro:IPR036860|rcsb pdb:2CS0|go:"GO:0005737"(cytoplasm)|refseq:NP_116244.1|refseq:NP_001278203.1|refseq:NM_032855.3(identity)|entrezgene/locuslink:84941(identity)	refseq:NM_203453.3(identity)|entrezgene/locuslink:403313(identity)	-	-	no-uniprot-update:	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: ABL2 (P42684)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:Y01YjkfU/oOtbz2TdQcnm+lBWhs9606	rogid:+Z2B+dJTsflTkv7ROiuer/ulCws9606	intact-crc:23040E4F9355F759|rigid:RYfrqC2BXA6z3sxW1MRax8ofomY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-10696484	uniprotkb:O14713	-	intact:EBI-2127319|uniprotkb:O14714|uniprotkb:D6W4Y9|uniprotkb:Q53RS0|ensembl:ENSP00000347504|ensembl:ENSP00000353850	psi-mi:pgrmc1(display_short)|psi-mi:EBI-10696484(display_long)	psi-mi:itbp1_human(display_long)|uniprotkb:ITGB1BP1(gene name)|psi-mi:ITGB1BP1(display_short)|uniprotkb:ICAP1(gene name synonym)|uniprotkb:Integrin cytoplasmic domain-associated protein 1(gene name synonym)	psi-mi:"MI:1356"(validated two hybrid)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705196|imex:IM-22632-1053	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	entrezgene/locuslink:10857(identity)|refseq:NM_006667.4(identity)	refseq:XP_011508718.1|refseq:NP_004754.1|refseq:NP_071729.1|refseq:XP_016860758.1|refseq:XP_016860759.1|refseq:XP_016860756.1|refseq:XP_016860757.1|refseq:NP_001305995.1|refseq:NP_001305996.1|refseq:NP_001305997.1|refseq:XP_006711966.1|refseq:XP_005246240.1|refseq:XP_005246241.1|refseq:XP_005246242.1|refseq:XP_005246246.1|ensembl:ENSG00000119185(gene)|ensembl:ENST00000355346(transcript)|ensembl:ENST00000360635(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006933"(negative regulation of cell adhesion involved in substrate-bound cell migration)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033622"(integrin activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035148"(tube formation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051451"(myoblast migration)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090315"(negative regulation of protein targeting to membrane)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR019517|rcsb pdb:1K11|rcsb pdb:4DX8|rcsb pdb:4DX9|rcsb pdb:4JIF|refseq:NM_004763.3(identity)|entrezgene/locuslink:9270(identity)	-	no-uniprot-update:	-	comment:"Phosphorylation-dependent interaction. The interaction is only detected in the presence of the following kinases: FER (P16591), FGR (P09769), FYN (P06241)."|figure legend:Suppl. table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/04	2015/03/17	rogid:rMnUy1tXawu+c/+lVvFyzcL9yYc9606	rogid:QxRmizA77Dvcwg8rkqt1bt3sI2U9606	intact-crc:E723906CD1A218FC|rigid:GHmL0u6RXyBdLJ/aq9OjDSCjOCM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60636	uniprotkb:P62993	intact:EBI-3914288|uniprotkb:Q8WU05|uniprotkb:Q5TET2|ensembl:ENSP00000358529|uniprotkb:D6PTH4	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:tsn2_human(display_long)|uniprotkb:TSPAN2(gene name)|psi-mi:TSPAN2(display_short)|uniprotkb:Tetraspan NET-3(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0096"(pull down)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705322|imex:IM-22632-1054	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001295245.1|refseq:NP_005716.2|ensembl:ENSG00000134198(gene)|ensembl:ENST00000369516(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014005"(microglia development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042552"(myelination)|go:"GO:0043209"(myelin sheath)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061564"(axon development)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	-	-	-	figure legend:4B, C and D|comment:Phosphatase treatment greatly increases the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/04	2015/03/17	rogid:aAvB/0QxH0/5YF5dkbBh5wpz3uw9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rigid:G4awIUPqy2QhVyRj9zHTAk2jFhw	false	protein a tag:n-n|mutation disrupting interaction:124-124	glutathione s tranferase tag:n-n|sufficient binding region:75-160	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92569	uniprotkb:O60636	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-3914288|uniprotkb:Q8WU05|uniprotkb:Q5TET2|ensembl:ENSP00000358529|uniprotkb:D6PTH4	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:tsn2_human(display_long)|uniprotkb:TSPAN2(gene name)|psi-mi:TSPAN2(display_short)|uniprotkb:Tetraspan NET-3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705349|imex:IM-22632-1055	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1	refseq:NP_001295245.1|refseq:NP_005716.2|ensembl:ENSG00000134198(gene)|ensembl:ENST00000369516(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014005"(microglia development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042552"(myelination)|go:"GO:0043209"(myelin sheath)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061564"(axon development)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503	-	-	-	figure legend:4B, C and D|comment:Phosphatase treatment greatly increases the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:aAvB/0QxH0/5YF5dkbBh5wpz3uw9606	rigid:AEsV8g0Fyz4xtwg2nZ8m7vUkrK0	false	glutathione s tranferase tag:n-n	flag tag:n-n|mutation disrupting interaction:124-124	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92569	uniprotkb:O60636	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-3914288|uniprotkb:Q8WU05|uniprotkb:Q5TET2|ensembl:ENSP00000358529|uniprotkb:D6PTH4	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:tsn2_human(display_long)|uniprotkb:TSPAN2(gene name)|psi-mi:TSPAN2(display_short)|uniprotkb:Tetraspan NET-3(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705380|imex:IM-22632-1056	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1	refseq:NP_001295245.1|refseq:NP_005716.2|ensembl:ENSG00000134198(gene)|ensembl:ENST00000369516(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014005"(microglia development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042552"(myelination)|go:"GO:0043209"(myelin sheath)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061564"(axon development)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503	-	-	-	figure legend:4E and suppl. fig. S9B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:aAvB/0QxH0/5YF5dkbBh5wpz3uw9606	rigid:AEsV8g0Fyz4xtwg2nZ8m7vUkrK0	false	glutathione s tranferase tag:n-n	sufficient binding region:117-131|O4'-phospho-L-tyrosine:124-124|sufficient binding region:53-67|O4'-phospho-L-tyrosine:60-60	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P62993	uniprotkb:O60636	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-3914288|uniprotkb:Q8WU05|uniprotkb:Q5TET2|ensembl:ENSP00000358529|uniprotkb:D6PTH4	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:tsn2_human(display_long)|uniprotkb:TSPAN2(gene name)|psi-mi:TSPAN2(display_short)|uniprotkb:Tetraspan NET-3(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705412|imex:IM-22632-1057	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	refseq:NP_001295245.1|refseq:NP_005716.2|ensembl:ENSG00000134198(gene)|ensembl:ENST00000369516(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014005"(microglia development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042552"(myelination)|go:"GO:0043209"(myelin sheath)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061564"(axon development)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503	-	-	-	figure legend:4E and suppl. fig. S9B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:aAvB/0QxH0/5YF5dkbBh5wpz3uw9606	rigid:G4awIUPqy2QhVyRj9zHTAk2jFhw	false	glutathione s tranferase tag:n-n|sufficient binding region:75-160	sufficient binding region:117-131|O4'-phospho-L-tyrosine:124-124	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P62993	uniprotkb:P35569	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-400825	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:irs1_mouse(display_long)|uniprotkb:Irs1(gene name)|psi-mi:Irs1(display_short)|uniprotkb:Irs-1(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705500|imex:IM-22632-1058	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	refseq:NP_034700.2|mint:P35569|dip:DIP-32456N|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031000"(response to caffeine)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070094"(positive regulation of glucagon secretion)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0090275"(negative regulation of somatostatin secretion)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:1AYB|rcsb pdb:5AXI|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749	-	-	-	figure legend:Suppl. fig. S9A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:S9ooRqBQ2LriTIe+f2hSyxU8oP010090	rigid:DeI+u+cdwuHUn8yR9hmR7TfS6u4	false	glutathione s tranferase tag:n-n|sufficient binding region:75-160	sufficient binding region:928-942|O4'-phospho-L-tyrosine:953-953	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q92569	uniprotkb:P35569	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-400825	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:irs1_mouse(display_long)|uniprotkb:Irs1(gene name)|psi-mi:Irs1(display_short)|uniprotkb:Irs-1(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705516|imex:IM-22632-1059	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1	refseq:NP_034700.2|mint:P35569|dip:DIP-32456N|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031000"(response to caffeine)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070094"(positive regulation of glucagon secretion)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0090275"(negative regulation of somatostatin secretion)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:1AYB|rcsb pdb:5AXI|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749	-	-	-	figure legend:Suppl. fig. S9A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:S9ooRqBQ2LriTIe+f2hSyxU8oP010090	rigid:0sdstvSRENhBx6LnU9YKRHwfrnw	false	glutathione s tranferase tag:n-n	sufficient binding region:928-942|O4'-phospho-L-tyrosine:953-953	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P62993	uniprotkb:P62491	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-745098|uniprotkb:P24410|uniprotkb:Q5TZN9|uniprotkb:Q9JLX1|ensembl:ENSP00000261890|uniprotkb:B2R4B6|uniprotkb:B4DT13	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:rb11a_human(display_long)|uniprotkb:YL8(gene name synonym)|uniprotkb:RAB11A(gene name)|psi-mi:RAB11A(display_short)|uniprotkb:RAB11(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705533|imex:IM-22632-1060	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	ensembl:ENSG00000103769(gene)|ensembl:ENST00000261890(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008017"(microtubule binding)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010796"(regulation of multivesicular body size)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|refseq:NP_001193765.1|refseq:NP_004654.1|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0031982"(vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990182"(exosomal secretion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62491|rcsb pdb:1OIV|rcsb pdb:1OIW|rcsb pdb:1OIX|rcsb pdb:1YZK|rcsb pdb:2D7C|rcsb pdb:2GZD|rcsb pdb:2GZH|rcsb pdb:2HV8|rcsb pdb:4C4P|rcsb pdb:4D0L|rcsb pdb:4D0M|rcsb pdb:4LWZ|rcsb pdb:4LX0|rcsb pdb:4UJ3|rcsb pdb:4UJ4|rcsb pdb:4UJ5|rcsb pdb:5C46|rcsb pdb:5C4G|rcsb pdb:5EUQ|rcsb pdb:5EZ5|rcsb pdb:5FBL|rcsb pdb:5FBQ|rcsb pdb:5FBR|rcsb pdb:5FBV|rcsb pdb:5FBW|rcsb pdb:5JCZ|rcsb pdb:6DJL|rcsb pdb:6IXV|reactome:R-HSA-1445148|reactome:R-HSA-432040|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|go:"GO:0019905"(syntaxin binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030133"(transport vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0030424"(axon)|dip:DIP-29138N	-	-	-	figure legend:Suppl. fig. S9A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:FjkzGzN2VDTyv94M9vD/EJC2qoU9606	rigid:rm0xLmFYxCAeqOo5EHm4J9ytPPc	false	glutathione s tranferase tag:n-n|sufficient binding region:75-160	sufficient binding region:92-106|O4'-phospho-L-tyrosine:100-100	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q92569	uniprotkb:P62491	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-745098|uniprotkb:P24410|uniprotkb:Q5TZN9|uniprotkb:Q9JLX1|ensembl:ENSP00000261890|uniprotkb:B2R4B6|uniprotkb:B4DT13	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:rb11a_human(display_long)|uniprotkb:YL8(gene name synonym)|uniprotkb:RAB11A(gene name)|psi-mi:RAB11A(display_short)|uniprotkb:RAB11(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705545|imex:IM-22632-1061	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1	ensembl:ENSG00000103769(gene)|ensembl:ENST00000261890(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008017"(microtubule binding)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010796"(regulation of multivesicular body size)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|refseq:NP_001193765.1|refseq:NP_004654.1|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0031982"(vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990182"(exosomal secretion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62491|rcsb pdb:1OIV|rcsb pdb:1OIW|rcsb pdb:1OIX|rcsb pdb:1YZK|rcsb pdb:2D7C|rcsb pdb:2GZD|rcsb pdb:2GZH|rcsb pdb:2HV8|rcsb pdb:4C4P|rcsb pdb:4D0L|rcsb pdb:4D0M|rcsb pdb:4LWZ|rcsb pdb:4LX0|rcsb pdb:4UJ3|rcsb pdb:4UJ4|rcsb pdb:4UJ5|rcsb pdb:5C46|rcsb pdb:5C4G|rcsb pdb:5EUQ|rcsb pdb:5EZ5|rcsb pdb:5FBL|rcsb pdb:5FBQ|rcsb pdb:5FBR|rcsb pdb:5FBV|rcsb pdb:5FBW|rcsb pdb:5JCZ|rcsb pdb:6DJL|rcsb pdb:6IXV|reactome:R-HSA-1445148|reactome:R-HSA-432040|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|go:"GO:0019905"(syntaxin binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030133"(transport vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0030424"(axon)|dip:DIP-29138N	-	-	-	figure legend:Suppl. fig. S9A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:FjkzGzN2VDTyv94M9vD/EJC2qoU9606	rigid:SoFxq021WkV3UcfPv5tVC6dwTr0	false	glutathione s tranferase tag:n-n	sufficient binding region:92-106|O4'-phospho-L-tyrosine:100-100	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P62993	uniprotkb:O60636	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-3914288|uniprotkb:Q8WU05|uniprotkb:Q5TET2|ensembl:ENSP00000358529|uniprotkb:D6PTH4	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:tsn2_human(display_long)|uniprotkb:TSPAN2(gene name)|psi-mi:TSPAN2(display_short)|uniprotkb:Tetraspan NET-3(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705564|imex:IM-22632-1062	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	refseq:NP_001295245.1|refseq:NP_005716.2|ensembl:ENSG00000134198(gene)|ensembl:ENST00000369516(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014005"(microglia development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042552"(myelination)|go:"GO:0043209"(myelin sheath)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061564"(axon development)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503	go:"GO:0031253"(cell projection membrane)	-	-	figure legend:4G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:aAvB/0QxH0/5YF5dkbBh5wpz3uw9606	rigid:G4awIUPqy2QhVyRj9zHTAk2jFhw	false	cYFP:n-n	nYFP:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92569	uniprotkb:O60636	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-3914288|uniprotkb:Q8WU05|uniprotkb:Q5TET2|ensembl:ENSP00000358529|uniprotkb:D6PTH4	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:tsn2_human(display_long)|uniprotkb:TSPAN2(gene name)|psi-mi:TSPAN2(display_short)|uniprotkb:Tetraspan NET-3(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705573|imex:IM-22632-1063	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1	refseq:NP_001295245.1|refseq:NP_005716.2|ensembl:ENSG00000134198(gene)|ensembl:ENST00000369516(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014005"(microglia development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042552"(myelination)|go:"GO:0043209"(myelin sheath)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061564"(axon development)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503	go:"GO:0005829"(cytosol)	-	-	figure legend:4G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:aAvB/0QxH0/5YF5dkbBh5wpz3uw9606	rigid:AEsV8g0Fyz4xtwg2nZ8m7vUkrK0	false	cYFP:n-n	nYFP:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P06400	uniprotkb:P62993	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705583|imex:IM-22632-1064	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	go:"GO:0005634"(nucleus)	-	-	figure legend:Suppl. fig. S10|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2015/03/17	rogid:xidCNX96KlQzu160polvT61k4Zw9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rigid:KAHMJQFt20oWWb7C6Rd4QnhRCGQ	false	nYFP:n-n	cYFP:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92569	uniprotkb:Q5SXH7-1	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-26412802	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:q5sxh7-1(display_long)|uniprotkb:PLEKHS1(gene name)|psi-mi:PLEKHS1(display_short)|uniprotkb:C10orf81(gene name synonym)|uniprotkb:Epididymis luminal protein 185(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Grossmann et al. (2015)	pubmed:25814554|imex:IM-22632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10705601|imex:IM-22632-1065	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1	intact:EBI-10691507(isoform-parent)	go:"GO:0005829"(cytosol)	-	-	figure legend:Suppl. fig. S10|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/04	2020/10/22	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:8OuCSDcvw9rtC0JZC596NetxIKA9606	rigid:/gCqH01nPA8E1ZE/l/NkTtgRxWo	false	cYFP:n-n	nYFP:n-n|sufficient binding region:181-462	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)