#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P26045	uniprotkb:Q14524	intact:EBI-1047946|uniprotkb:A0AUW9|uniprotkb:E7EN99|uniprotkb:E9PGU7|ensembl:ENSP00000363667	intact:EBI-726858|uniprotkb:Q59H93|uniprotkb:E9PEF3|uniprotkb:A5H1P8|uniprotkb:A6N922|uniprotkb:A6N923|uniprotkb:B2RTU0|uniprotkb:Q75RX9|uniprotkb:Q75RY0|uniprotkb:Q86UR3|uniprotkb:Q8IZC9|uniprotkb:Q96J69|uniprotkb:E9PEK2|uniprotkb:E9PFW7|uniprotkb:E7ET19|intact:EBI-28981518|ensembl:ENSP00000328968	psi-mi:ptn3_human(display_long)|uniprotkb:Protein-tyrosine phosphatase H1(gene name synonym)|uniprotkb:PTPN3(gene name)|psi-mi:PTPN3(display_short)|uniprotkb:PTPH1(gene name synonym)	psi-mi:scn5a_human(display_long)|uniprotkb:Sodium channel protein type V subunit alpha(gene name synonym)|uniprotkb:Voltage-gated sodium channel subunit alpha Nav1.5(gene name synonym)|uniprotkb:Sodium channel protein cardiac muscle subunit alpha(gene name synonym)|uniprotkb:SCN5A(gene name)|psi-mi:SCN5A(display_short)|uniprotkb:hH1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Jespersen et al. (2006)	mint:MINT-8311161|pubmed:16930557|doi:10.1016/j.bbrc.2006.08.014	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8620386|mint:MINT-8311167	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138840.1|refseq:NP_001138843.1|refseq:NP_002820.3|refseq:NP_001138841.1|refseq:NP_001138842.1|refseq:XP_011517191.1|refseq:XP_016870444.1|refseq:XP_016870446.1|ensembl:ENSG00000070159(gene)|ensembl:ENST00000374541(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051117"(ATPase binding)|go:"GO:0097421"(liver regeneration)|go:"GO:0098902"(regulation of membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:P26045|rcsb pdb:2B49|rcsb pdb:4QUM|rcsb pdb:4QUN|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4RI4|rcsb pdb:4RI5|rcsb pdb:4S0G|rcsb pdb:6HKS|rcsb pdb:6T36|reactome:R-HSA-182971|reactome:R-HSA-5675221|refseq:XP_006717262.1|refseq:XP_006717267.1|dip:DIP-38839N|mint:MINT-8311173(identity)|uniprotkb:P26045(original identifier)	refseq:NP_000326.2|refseq:NP_001092874.1|refseq:NP_001092875.1|refseq:NP_001153632.1|refseq:NP_001153633.1|refseq:NP_932173.1|ensembl:ENSP00000328968|ensembl:ENST00000423572|ensembl:ENSP00000398266|ensembl:ENSG00000183873(gene)|ensembl:ENST00000333535(transcript)|go:"GO:0001518"(voltage-gated sodium channel complex)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0003360"(brainstem development)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0021549"(cerebellum development)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060371"(regulation of atrial cardiac muscle cell membrane depolarization)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086006"(voltage-gated sodium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086016"(AV node cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086047"(membrane depolarization during Purkinje myocyte cell action potential)|go:"GO:0086048"(membrane depolarization during bundle of His cell action potential)|go:"GO:0086060"(voltage-gated sodium channel activity involved in AV node cell action potential)|go:"GO:0086061"(voltage-gated sodium channel activity involved in bundle of His cell action potential)|go:"GO:0086062"(voltage-gated sodium channel activity involved in Purkinje myocyte action potential)|go:"GO:0086063"(voltage-gated sodium channel activity involved in SA node cell action potential)|go:"GO:0086067"(AV node cell to bundle of His cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|interpro:IPR001696(Na+ channel)|interpro:IPR005821(Ion transport)|interpro:IPR008053(Na+ channel 5)|interpro:IPR010526(Sodium ion transport-associated)|interpro:IPR024583|interpro:IPR027359|interpro:IPR043203|interpro:IPR044564|rcsb pdb:2KBI|rcsb pdb:2L53|go:"GO:0086043"(bundle of His cell action potential)|rcsb pdb:4DCK|rcsb pdb:4DJC|rcsb pdb:4JQ0|rcsb pdb:4OVN|rcsb pdb:5DBR|rcsb pdb:6LQA|rcsb pdb:6MUD|rcsb pdb:7DTC|rcsb pdb:7L83|reactome:R-HSA-445095|reactome:R-HSA-5576892|dip:DIP-38416N|dip:DIP-46144N|mint:MINT-8311168(identity)|uniprotkb:Q14524(original identifier)	-	-	caution:This sequence has been withdrawn from Uniprot.	figure legend:T1|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:4932(baker's yeast-l40)|taxid:4932(Saccharomyces cerevisiae)	-	2012/02/13	2014/10/16	rogid:7LM4ANS9aclQf1SZfn/Jmxj2fUA9606	rogid:WJ23sEfaxGTHEngY52K92JChA6U9606	intact-crc:6DD87B8A601B4CA4|rigid:24Ybb7WZaYYbEtk+5W48clSqAJY	false	-	binding-associated region:1950-2016(MINT-8311171)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26045	uniprotkb:Q14524	intact:EBI-1047946|uniprotkb:A0AUW9|uniprotkb:E7EN99|uniprotkb:E9PGU7|ensembl:ENSP00000363667	intact:EBI-726858|uniprotkb:Q59H93|uniprotkb:E9PEF3|uniprotkb:A5H1P8|uniprotkb:A6N922|uniprotkb:A6N923|uniprotkb:B2RTU0|uniprotkb:Q75RX9|uniprotkb:Q75RY0|uniprotkb:Q86UR3|uniprotkb:Q8IZC9|uniprotkb:Q96J69|uniprotkb:E9PEK2|uniprotkb:E9PFW7|uniprotkb:E7ET19|intact:EBI-28981518|ensembl:ENSP00000328968	psi-mi:ptn3_human(display_long)|uniprotkb:Protein-tyrosine phosphatase H1(gene name synonym)|uniprotkb:PTPN3(gene name)|psi-mi:PTPN3(display_short)|uniprotkb:PTPH1(gene name synonym)	psi-mi:scn5a_human(display_long)|uniprotkb:Sodium channel protein type V subunit alpha(gene name synonym)|uniprotkb:Voltage-gated sodium channel subunit alpha Nav1.5(gene name synonym)|uniprotkb:Sodium channel protein cardiac muscle subunit alpha(gene name synonym)|uniprotkb:SCN5A(gene name)|psi-mi:SCN5A(display_short)|uniprotkb:hH1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Jespersen et al. (2006)	mint:MINT-8311161|pubmed:16930557|doi:10.1016/j.bbrc.2006.08.014	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8620444|mint:MINT-8311179	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138840.1|refseq:NP_001138843.1|refseq:NP_002820.3|refseq:NP_001138841.1|refseq:NP_001138842.1|refseq:XP_011517191.1|refseq:XP_016870444.1|refseq:XP_016870446.1|ensembl:ENSG00000070159(gene)|ensembl:ENST00000374541(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051117"(ATPase binding)|go:"GO:0097421"(liver regeneration)|go:"GO:0098902"(regulation of membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:P26045|rcsb pdb:2B49|rcsb pdb:4QUM|rcsb pdb:4QUN|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4RI4|rcsb pdb:4RI5|rcsb pdb:4S0G|rcsb pdb:6HKS|rcsb pdb:6T36|reactome:R-HSA-182971|reactome:R-HSA-5675221|refseq:XP_006717262.1|refseq:XP_006717267.1|dip:DIP-38839N|mint:MINT-8311187(identity)|uniprotkb:P26045(original identifier)	refseq:NP_000326.2|refseq:NP_001092874.1|refseq:NP_001092875.1|refseq:NP_001153632.1|refseq:NP_001153633.1|refseq:NP_932173.1|ensembl:ENSP00000328968|ensembl:ENST00000423572|ensembl:ENSP00000398266|ensembl:ENSG00000183873(gene)|ensembl:ENST00000333535(transcript)|go:"GO:0001518"(voltage-gated sodium channel complex)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0003360"(brainstem development)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0021549"(cerebellum development)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060371"(regulation of atrial cardiac muscle cell membrane depolarization)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086006"(voltage-gated sodium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086016"(AV node cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086047"(membrane depolarization during Purkinje myocyte cell action potential)|go:"GO:0086048"(membrane depolarization during bundle of His cell action potential)|go:"GO:0086060"(voltage-gated sodium channel activity involved in AV node cell action potential)|go:"GO:0086061"(voltage-gated sodium channel activity involved in bundle of His cell action potential)|go:"GO:0086062"(voltage-gated sodium channel activity involved in Purkinje myocyte action potential)|go:"GO:0086063"(voltage-gated sodium channel activity involved in SA node cell action potential)|go:"GO:0086067"(AV node cell to bundle of His cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|interpro:IPR001696(Na+ channel)|interpro:IPR005821(Ion transport)|interpro:IPR008053(Na+ channel 5)|interpro:IPR010526(Sodium ion transport-associated)|interpro:IPR024583|interpro:IPR027359|interpro:IPR043203|interpro:IPR044564|rcsb pdb:2KBI|rcsb pdb:2L53|go:"GO:0086043"(bundle of His cell action potential)|rcsb pdb:4DCK|rcsb pdb:4DJC|rcsb pdb:4JQ0|rcsb pdb:4OVN|rcsb pdb:5DBR|rcsb pdb:6LQA|rcsb pdb:6MUD|rcsb pdb:7DTC|rcsb pdb:7L83|reactome:R-HSA-445095|reactome:R-HSA-5576892|dip:DIP-38416N|dip:DIP-46144N|mint:MINT-8311180(identity)|uniprotkb:Q14524(original identifier)	-	-	caution:This sequence has been withdrawn from Uniprot.	figure legend:F1|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/13	2014/10/16	rogid:7LM4ANS9aclQf1SZfn/Jmxj2fUA9606	rogid:WJ23sEfaxGTHEngY52K92JChA6U9606	intact-crc:839B3B86335C838A|rigid:24Ybb7WZaYYbEtk+5W48clSqAJY	false	-	binding-associated region:2013-2016(MINT-8311183)|glutathione s tranferase tag:?-?(MINT-8311185)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)