#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P19438	uniprotkb:P01375-PRO_0000034424	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	intact:EBI-2905409	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:p01375-pro_0000034424(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Reed et al. (1997)	pubmed:9488135|imex:IM-20503	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2905436|imex:IM-20503-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	intact:EBI-359977(chain-parent)	-	-	chain-seq-start:77|chain-seq-end:233	figure legend:Table I|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/08/10	2014/10/16	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rogid:o0hR23PIZTvXSgaCCPohIxk7cFE9606	intact-crc:46DDE4192E67210F|rigid:NDppS3jk4S5GLOs1emHcReLbcLs	false	-	125i radiolabel:?-?|mutation decreasing interaction:31-31	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P20333	uniprotkb:P01375-PRO_0000034424	intact:EBI-358983|uniprotkb:Q16042|uniprotkb:Q6YI29|uniprotkb:Q9UIH1|uniprotkb:B1AJZ3|ensembl:ENSP00000365435	intact:EBI-2905409	psi-mi:tnr1b_human(display_long)|uniprotkb:TNFRSF1B(gene name)|psi-mi:TNFRSF1B(display_short)|uniprotkb:TNFBR(gene name synonym)|uniprotkb:TNFR2(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 2(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type II(gene name synonym)|uniprotkb:p75(gene name synonym)|uniprotkb:p80 TNF-alpha receptor(gene name synonym)	psi-mi:p01375-pro_0000034424(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Reed et al. (1997)	pubmed:9488135|imex:IM-20503	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2905473|imex:IM-20503-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001057.1|ensembl:ENSG00000028137(gene)|ensembl:ENST00000376259(transcript)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0002724"(regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007568"(aging)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043196"(varicosity)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050779"(RNA destabilization)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150098"(glial cell-neuron signaling)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:2001141"(regulation of RNA biosynthetic process)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020411|interpro:IPR033996|rcsb pdb:1CA9|rcsb pdb:3ALQ|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-6798695|dip:DIP-78N	intact:EBI-359977(chain-parent)	-	-	chain-seq-start:77|chain-seq-end:233	figure legend:Table I|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/08/10	2015/11/18	rogid:j53K3KYEzPRDmeDKcUxqoK7SoGY9606	rogid:o0hR23PIZTvXSgaCCPohIxk7cFE9606	intact-crc:84516FB825B47873|rigid:DYl4Vo/uiYWS7dhsG1rlwHHeJbA	false	-	125i radiolabel:?-?|mutation decreasing interaction:31-31	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P01375-PRO_0000034424	uniprotkb:P01375-PRO_0000034424	intact:EBI-2905409	intact:EBI-2905409	psi-mi:p01375-pro_0000034424(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)	psi-mi:p01375-pro_0000034424(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Reed et al. (1997)	pubmed:9488135|imex:IM-20503	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2905428|wwpdb:1a8m|imex:IM-20503-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-359977(chain-parent)	intact:EBI-359977(chain-parent)	-	chain-seq-start:77|chain-seq-end:233	chain-seq-start:77|chain-seq-end:233	3d-resolution:TNF R31D 2.3A|3d-r-factors:"TNF R31D R-working:21.8% R-free:24.0%"|comment:Wild type TNF also crystallized but no reference is available in PDB|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/08/10	2014/10/16	rogid:o0hR23PIZTvXSgaCCPohIxk7cFE9606	rogid:o0hR23PIZTvXSgaCCPohIxk7cFE9606	intact-crc:9F77DFF80D50DBE1|rigid:MaLh3a4yjhlJZTXKgkaK8x7cHvw	false	mutation:31-31	mutation:31-31	3	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)