#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9HAV4	uniprotkb:P62826	intact:EBI-517949|uniprotkb:Q5JTE6|uniprotkb:Q96G48|uniprotkb:Q96HN3|uniprotkb:Q9BWM6|uniprotkb:Q9BZV5|uniprotkb:Q9H9M4|uniprotkb:Q9NT89|uniprotkb:Q9NW39|uniprotkb:Q9ULC9|ensembl:ENSP00000265351	intact:EBI-286642|uniprotkb:P17080|uniprotkb:P28746|uniprotkb:P28747|uniprotkb:Q6IPB2|uniprotkb:Q86V08|uniprotkb:Q8NI90|uniprotkb:Q9CZA2|uniprotkb:Q9CSP3|uniprotkb:Q9CWI7|uniprotkb:Q9UDJ5|uniprotkb:Q9UEU9|uniprotkb:A8K3Z8|ensembl:ENSP00000376176|ensembl:ENSP00000446215	psi-mi:xpo5_human(display_long)|uniprotkb:Ran-binding protein 21(gene name synonym)|uniprotkb:XPO5(gene name)|psi-mi:XPO5(display_short)|uniprotkb:KIAA1291(gene name synonym)|uniprotkb:RANBP21(gene name synonym)	psi-mi:ran_human(display_long)|uniprotkb:GTPase Ran(gene name synonym)|uniprotkb:Ras-related nuclear protein(gene name synonym)|uniprotkb:Ras-like protein TC4(gene name synonym)|uniprotkb:Androgen receptor-associated protein 24(gene name synonym)|uniprotkb:RAN(gene name)|psi-mi:RAN(display_short)|uniprotkb:ARA24(gene name synonym)|uniprotkb:OK/SW-cl.81(orf name)	psi-mi:"MI:0096"(pull down)	Melo et al. (2010)	pubmed:20951941|imex:IM-15157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2938145|imex:IM-15157-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065801.1|dip:DIP-34547N|rcsb pdb:5YU7|reactome:R-HSA-203927|ensembl:ENSG00000124571(gene)|ensembl:ENST00000265351(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:1900370"(positive regulation of RNA interference)|go:"GO:1905172"(RISC complex binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040018|mint:Q9HAV4|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|rcsb pdb:3A6P|rcsb pdb:5YU6	refseq:NP_006316.1|refseq:NP_001287725.1|refseq:NP_001287726.1|dip:DIP-5929N|ensembl:ENSG00000132341(gene)|ensembl:ENST00000392369(transcript)|ensembl:ENST00000543796(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0016020"(membrane)|go:"GO:0016032"(viral process)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0061015"(snRNA import into nucleus)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR001806(Ras GTPase)|interpro:IPR002041(Ran GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62826|rcsb pdb:1I2M|rcsb pdb:1IBR|rcsb pdb:1K5D|rcsb pdb:1K5G|rcsb pdb:1QBK|rcsb pdb:1RRP|rcsb pdb:2MMC|rcsb pdb:2MMG|rcsb pdb:2N1B|rcsb pdb:3CH5|rcsb pdb:3EA5|rcsb pdb:3GJ0|rcsb pdb:3GJ3|rcsb pdb:3GJ4|rcsb pdb:3GJ5|rcsb pdb:3GJ6|rcsb pdb:3GJ7|rcsb pdb:3GJ8|rcsb pdb:3GJX|rcsb pdb:3NBY|rcsb pdb:3NBZ|rcsb pdb:3NC0|rcsb pdb:3NC1|rcsb pdb:3ZJY|rcsb pdb:4C0Q|rcsb pdb:4GMX|rcsb pdb:4GPT|rcsb pdb:4HAT|rcsb pdb:4HAU|rcsb pdb:4HAV|rcsb pdb:4HAW|rcsb pdb:4HAX|rcsb pdb:4HAY|rcsb pdb:4HAZ|rcsb pdb:4HB0|rcsb pdb:4HB2|rcsb pdb:4HB3|rcsb pdb:4HB4|rcsb pdb:4OL0|rcsb pdb:4WVF|rcsb pdb:5CIQ|rcsb pdb:5CIT|rcsb pdb:5CIW|rcsb pdb:5CJ2|rcsb pdb:5CLL|rcsb pdb:5CLQ|rcsb pdb:5DH9|rcsb pdb:5DHA|rcsb pdb:5DHF|rcsb pdb:5DI9|rcsb pdb:5DIF|rcsb pdb:5DIS|rcsb pdb:5DLQ|rcsb pdb:5FYQ|rcsb pdb:5JLJ|rcsb pdb:5UWH|rcsb pdb:5UWI|rcsb pdb:5UWJ|rcsb pdb:5UWO|rcsb pdb:5UWP|rcsb pdb:5UWQ|rcsb pdb:5UWR|rcsb pdb:5UWS|rcsb pdb:5UWT|rcsb pdb:5UWU|rcsb pdb:5UWW|rcsb pdb:5YRO|rcsb pdb:5YST|rcsb pdb:5YSU|rcsb pdb:5YTB|rcsb pdb:5ZPU|rcsb pdb:6A38|rcsb pdb:6A3A|rcsb pdb:6A3B|rcsb pdb:6A3C|rcsb pdb:6A3E|rcsb pdb:6CIT|rcsb pdb:6KFT|rcsb pdb:6LQ9|rcsb pdb:6M60|rcsb pdb:6M6X|rcsb pdb:6Q82|rcsb pdb:6Q84|rcsb pdb:6TVO|rcsb pdb:6X2M|rcsb pdb:6X2O|rcsb pdb:6X2P|rcsb pdb:6X2R|rcsb pdb:6X2S|rcsb pdb:6X2U|rcsb pdb:6X2V|rcsb pdb:6X2W|rcsb pdb:6X2X|rcsb pdb:6X2Y|rcsb pdb:6XJP|rcsb pdb:6XJR|rcsb pdb:6XJS|rcsb pdb:6XJT|rcsb pdb:6XJU|rcsb pdb:7B51|rcsb pdb:7CND|rcsb pdb:7L5E|reactome:R-HSA-165054|reactome:R-HSA-1655829|reactome:R-HSA-168333|reactome:R-HSA-180746|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-6784531|reactome:R-HSA-9615933	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 4A.|comment:Both wild-type and mutant forms of XPO5 were able to bind to Ran in a GTP-dependent manner.  The addition of pre-let-7a increased the affinity of XPO5WT to bind GST-Ran.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/10/20	2014/10/16	rogid:wuUAxvyCl/u7CRtQLMK9McSoUrM9606	rogid:trIUv5n3nI5d0rkfDTgw/6ubxMA9606	intact-crc:C97601DF9265EA66|rigid:F/LoGjJIFd7HLP+T7SsV0opjrUw	false	his tag:?-?	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HAV4	intact:EBI-2938324	intact:EBI-517949|uniprotkb:Q5JTE6|uniprotkb:Q96G48|uniprotkb:Q96HN3|uniprotkb:Q9BWM6|uniprotkb:Q9BZV5|uniprotkb:Q9H9M4|uniprotkb:Q9NT89|uniprotkb:Q9NW39|uniprotkb:Q9ULC9|ensembl:ENSP00000265351	ensembl:ENSG00000199165|rnacentral:URS00005EB5B7_9606|mirbase:MI0000060	psi-mi:xpo5_human(display_long)|uniprotkb:Ran-binding protein 21(gene name synonym)|uniprotkb:XPO5(gene name)|psi-mi:XPO5(display_short)|uniprotkb:KIAA1291(gene name synonym)|uniprotkb:RANBP21(gene name synonym)	psi-mi:pre-let-7a-1(display_short)|psi-mi:EBI-2938324(display_long)	psi-mi:"MI:0663"(confocal microscopy)	Melo et al. (2010)	pubmed:20951941|imex:IM-15157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2938234|imex:IM-15157-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:2359"(ds rna)	refseq:NP_065801.1|dip:DIP-34547N|rcsb pdb:5YU7|reactome:R-HSA-203927|ensembl:ENSG00000124571(gene)|ensembl:ENST00000265351(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:1900370"(positive regulation of RNA interference)|go:"GO:1905172"(RISC complex binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040018|mint:Q9HAV4|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|rcsb pdb:3A6P|rcsb pdb:5YU6	-	-	-	-	figure legend:Fig 4B.|comment:Biotin labeled pre-let-7a was detected in the cytoplasm 1 hr after transfection and disappeared to the cytoplasm 2 hr after co-transfection with WT XP05.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct-15)|taxid:9606(Human colorectal adenocarcinoma cell line HCT-15)	-	2010/10/20	2015/08/24	rogid:wuUAxvyCl/u7CRtQLMK9McSoUrM9606	crc64:577F8A4C0C754DAA	intact-crc:36AA4B3D475E1851	false	flag tag:n-n	biotin tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
intact:EBI-2938324	uniprotkb:P62826	ensembl:ENSG00000199165|rnacentral:URS00005EB5B7_9606|mirbase:MI0000060	intact:EBI-286642|uniprotkb:P17080|uniprotkb:P28746|uniprotkb:P28747|uniprotkb:Q6IPB2|uniprotkb:Q86V08|uniprotkb:Q8NI90|uniprotkb:Q9CZA2|uniprotkb:Q9CSP3|uniprotkb:Q9CWI7|uniprotkb:Q9UDJ5|uniprotkb:Q9UEU9|uniprotkb:A8K3Z8|ensembl:ENSP00000376176|ensembl:ENSP00000446215	psi-mi:pre-let-7a-1(display_short)|psi-mi:EBI-2938324(display_long)	psi-mi:ran_human(display_long)|uniprotkb:GTPase Ran(gene name synonym)|uniprotkb:Ras-related nuclear protein(gene name synonym)|uniprotkb:Ras-like protein TC4(gene name synonym)|uniprotkb:Androgen receptor-associated protein 24(gene name synonym)|uniprotkb:RAN(gene name)|psi-mi:RAN(display_short)|uniprotkb:ARA24(gene name synonym)|uniprotkb:OK/SW-cl.81(orf name)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Melo et al. (2010)	pubmed:20951941|imex:IM-15157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2938338|imex:IM-15157-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:2359"(ds rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006316.1|refseq:NP_001287725.1|refseq:NP_001287726.1|dip:DIP-5929N|ensembl:ENSG00000132341(gene)|ensembl:ENST00000392369(transcript)|ensembl:ENST00000543796(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0016020"(membrane)|go:"GO:0016032"(viral process)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0061015"(snRNA import into nucleus)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR001806(Ras GTPase)|interpro:IPR002041(Ran GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62826|rcsb pdb:1I2M|rcsb pdb:1IBR|rcsb pdb:1K5D|rcsb pdb:1K5G|rcsb pdb:1QBK|rcsb pdb:1RRP|rcsb pdb:2MMC|rcsb pdb:2MMG|rcsb pdb:2N1B|rcsb pdb:3CH5|rcsb pdb:3EA5|rcsb pdb:3GJ0|rcsb pdb:3GJ3|rcsb pdb:3GJ4|rcsb pdb:3GJ5|rcsb pdb:3GJ6|rcsb pdb:3GJ7|rcsb pdb:3GJ8|rcsb pdb:3GJX|rcsb pdb:3NBY|rcsb pdb:3NBZ|rcsb pdb:3NC0|rcsb pdb:3NC1|rcsb pdb:3ZJY|rcsb pdb:4C0Q|rcsb pdb:4GMX|rcsb pdb:4GPT|rcsb pdb:4HAT|rcsb pdb:4HAU|rcsb pdb:4HAV|rcsb pdb:4HAW|rcsb pdb:4HAX|rcsb pdb:4HAY|rcsb pdb:4HAZ|rcsb pdb:4HB0|rcsb pdb:4HB2|rcsb pdb:4HB3|rcsb pdb:4HB4|rcsb pdb:4OL0|rcsb pdb:4WVF|rcsb pdb:5CIQ|rcsb pdb:5CIT|rcsb pdb:5CIW|rcsb pdb:5CJ2|rcsb pdb:5CLL|rcsb pdb:5CLQ|rcsb pdb:5DH9|rcsb pdb:5DHA|rcsb pdb:5DHF|rcsb pdb:5DI9|rcsb pdb:5DIF|rcsb pdb:5DIS|rcsb pdb:5DLQ|rcsb pdb:5FYQ|rcsb pdb:5JLJ|rcsb pdb:5UWH|rcsb pdb:5UWI|rcsb pdb:5UWJ|rcsb pdb:5UWO|rcsb pdb:5UWP|rcsb pdb:5UWQ|rcsb pdb:5UWR|rcsb pdb:5UWS|rcsb pdb:5UWT|rcsb pdb:5UWU|rcsb pdb:5UWW|rcsb pdb:5YRO|rcsb pdb:5YST|rcsb pdb:5YSU|rcsb pdb:5YTB|rcsb pdb:5ZPU|rcsb pdb:6A38|rcsb pdb:6A3A|rcsb pdb:6A3B|rcsb pdb:6A3C|rcsb pdb:6A3E|rcsb pdb:6CIT|rcsb pdb:6KFT|rcsb pdb:6LQ9|rcsb pdb:6M60|rcsb pdb:6M6X|rcsb pdb:6Q82|rcsb pdb:6Q84|rcsb pdb:6TVO|rcsb pdb:6X2M|rcsb pdb:6X2O|rcsb pdb:6X2P|rcsb pdb:6X2R|rcsb pdb:6X2S|rcsb pdb:6X2U|rcsb pdb:6X2V|rcsb pdb:6X2W|rcsb pdb:6X2X|rcsb pdb:6X2Y|rcsb pdb:6XJP|rcsb pdb:6XJR|rcsb pdb:6XJS|rcsb pdb:6XJT|rcsb pdb:6XJU|rcsb pdb:7B51|rcsb pdb:7CND|rcsb pdb:7L5E|reactome:R-HSA-165054|reactome:R-HSA-1655829|reactome:R-HSA-168333|reactome:R-HSA-180746|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-6784531|reactome:R-HSA-9615933	-	-	-	figure legend:Fig 4D, S4B.|comment:The biotin labeled pre-let-7a did not bind XPO5Mut in the presence of Ran and GTP.  However pre-let-7a formed a readily detectable complex when incubated with XPO5WT.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/10/20	2015/08/24	crc64:577F8A4C0C754DAA	rogid:trIUv5n3nI5d0rkfDTgw/6ubxMA9606	intact-crc:004AA743B2D160FA	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
intact:EBI-2938324	uniprotkb:Q9HAV4	ensembl:ENSG00000199165|rnacentral:URS00005EB5B7_9606|mirbase:MI0000060	intact:EBI-517949|uniprotkb:Q5JTE6|uniprotkb:Q96G48|uniprotkb:Q96HN3|uniprotkb:Q9BWM6|uniprotkb:Q9BZV5|uniprotkb:Q9H9M4|uniprotkb:Q9NT89|uniprotkb:Q9NW39|uniprotkb:Q9ULC9|ensembl:ENSP00000265351	psi-mi:pre-let-7a-1(display_short)|psi-mi:EBI-2938324(display_long)	psi-mi:xpo5_human(display_long)|uniprotkb:Ran-binding protein 21(gene name synonym)|uniprotkb:XPO5(gene name)|psi-mi:XPO5(display_short)|uniprotkb:KIAA1291(gene name synonym)|uniprotkb:RANBP21(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Melo et al. (2010)	pubmed:20951941|imex:IM-15157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2938338|imex:IM-15157-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:2359"(ds rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_065801.1|dip:DIP-34547N|rcsb pdb:5YU7|reactome:R-HSA-203927|ensembl:ENSG00000124571(gene)|ensembl:ENST00000265351(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:1900370"(positive regulation of RNA interference)|go:"GO:1905172"(RISC complex binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040018|mint:Q9HAV4|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|rcsb pdb:3A6P|rcsb pdb:5YU6	-	-	-	figure legend:Fig 4D, S4B.|comment:The biotin labeled pre-let-7a did not bind XPO5Mut in the presence of Ran and GTP.  However pre-let-7a formed a readily detectable complex when incubated with XPO5WT.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/10/20	2015/08/24	crc64:577F8A4C0C754DAA	rogid:wuUAxvyCl/u7CRtQLMK9McSoUrM9606	intact-crc:004AA743B2D160FA	false	biotin tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
intact:EBI-2938324	uniprotkb:P62826	ensembl:ENSG00000199165|rnacentral:URS00005EB5B7_9606|mirbase:MI0000060	intact:EBI-286642|uniprotkb:P17080|uniprotkb:P28746|uniprotkb:P28747|uniprotkb:Q6IPB2|uniprotkb:Q86V08|uniprotkb:Q8NI90|uniprotkb:Q9CZA2|uniprotkb:Q9CSP3|uniprotkb:Q9CWI7|uniprotkb:Q9UDJ5|uniprotkb:Q9UEU9|uniprotkb:A8K3Z8|ensembl:ENSP00000376176|ensembl:ENSP00000446215	psi-mi:pre-let-7a-1(display_short)|psi-mi:EBI-2938324(display_long)	psi-mi:ran_human(display_long)|uniprotkb:GTPase Ran(gene name synonym)|uniprotkb:Ras-related nuclear protein(gene name synonym)|uniprotkb:Ras-like protein TC4(gene name synonym)|uniprotkb:Androgen receptor-associated protein 24(gene name synonym)|uniprotkb:RAN(gene name)|psi-mi:RAN(display_short)|uniprotkb:ARA24(gene name synonym)|uniprotkb:OK/SW-cl.81(orf name)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Melo et al. (2010)	pubmed:20951941|imex:IM-15157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2939671|imex:IM-15157-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:2359"(ds rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006316.1|refseq:NP_001287725.1|refseq:NP_001287726.1|dip:DIP-5929N|ensembl:ENSG00000132341(gene)|ensembl:ENST00000392369(transcript)|ensembl:ENST00000543796(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0016020"(membrane)|go:"GO:0016032"(viral process)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0061015"(snRNA import into nucleus)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR001806(Ras GTPase)|interpro:IPR002041(Ran GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62826|rcsb pdb:1I2M|rcsb pdb:1IBR|rcsb pdb:1K5D|rcsb pdb:1K5G|rcsb pdb:1QBK|rcsb pdb:1RRP|rcsb pdb:2MMC|rcsb pdb:2MMG|rcsb pdb:2N1B|rcsb pdb:3CH5|rcsb pdb:3EA5|rcsb pdb:3GJ0|rcsb pdb:3GJ3|rcsb pdb:3GJ4|rcsb pdb:3GJ5|rcsb pdb:3GJ6|rcsb pdb:3GJ7|rcsb pdb:3GJ8|rcsb pdb:3GJX|rcsb pdb:3NBY|rcsb pdb:3NBZ|rcsb pdb:3NC0|rcsb pdb:3NC1|rcsb pdb:3ZJY|rcsb pdb:4C0Q|rcsb pdb:4GMX|rcsb pdb:4GPT|rcsb pdb:4HAT|rcsb pdb:4HAU|rcsb pdb:4HAV|rcsb pdb:4HAW|rcsb pdb:4HAX|rcsb pdb:4HAY|rcsb pdb:4HAZ|rcsb pdb:4HB0|rcsb pdb:4HB2|rcsb pdb:4HB3|rcsb pdb:4HB4|rcsb pdb:4OL0|rcsb pdb:4WVF|rcsb pdb:5CIQ|rcsb pdb:5CIT|rcsb pdb:5CIW|rcsb pdb:5CJ2|rcsb pdb:5CLL|rcsb pdb:5CLQ|rcsb pdb:5DH9|rcsb pdb:5DHA|rcsb pdb:5DHF|rcsb pdb:5DI9|rcsb pdb:5DIF|rcsb pdb:5DIS|rcsb pdb:5DLQ|rcsb pdb:5FYQ|rcsb pdb:5JLJ|rcsb pdb:5UWH|rcsb pdb:5UWI|rcsb pdb:5UWJ|rcsb pdb:5UWO|rcsb pdb:5UWP|rcsb pdb:5UWQ|rcsb pdb:5UWR|rcsb pdb:5UWS|rcsb pdb:5UWT|rcsb pdb:5UWU|rcsb pdb:5UWW|rcsb pdb:5YRO|rcsb pdb:5YST|rcsb pdb:5YSU|rcsb pdb:5YTB|rcsb pdb:5ZPU|rcsb pdb:6A38|rcsb pdb:6A3A|rcsb pdb:6A3B|rcsb pdb:6A3C|rcsb pdb:6A3E|rcsb pdb:6CIT|rcsb pdb:6KFT|rcsb pdb:6LQ9|rcsb pdb:6M60|rcsb pdb:6M6X|rcsb pdb:6Q82|rcsb pdb:6Q84|rcsb pdb:6TVO|rcsb pdb:6X2M|rcsb pdb:6X2O|rcsb pdb:6X2P|rcsb pdb:6X2R|rcsb pdb:6X2S|rcsb pdb:6X2U|rcsb pdb:6X2V|rcsb pdb:6X2W|rcsb pdb:6X2X|rcsb pdb:6X2Y|rcsb pdb:6XJP|rcsb pdb:6XJR|rcsb pdb:6XJS|rcsb pdb:6XJT|rcsb pdb:6XJU|rcsb pdb:7B51|rcsb pdb:7CND|rcsb pdb:7L5E|reactome:R-HSA-165054|reactome:R-HSA-1655829|reactome:R-HSA-168333|reactome:R-HSA-180746|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-6784531|reactome:R-HSA-9615933	-	-	-	figure legend:Fig 4D, S4B.|comment:The biotin labeled pre-let-7a did not bind XPO5Mut in the presence of Ran and GTP.  However pre-let-7a formed a readily detectable complex when incubated with XPO5WT and a supershift could be observed when the antihistidine antibody was added to the reaction.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/10/20	2015/08/24	crc64:577F8A4C0C754DAA	rogid:trIUv5n3nI5d0rkfDTgw/6ubxMA9606	intact-crc:0C6B8810733395CC	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
intact:EBI-2938324	uniprotkb:Q9HAV4	ensembl:ENSG00000199165|rnacentral:URS00005EB5B7_9606|mirbase:MI0000060	intact:EBI-517949|uniprotkb:Q5JTE6|uniprotkb:Q96G48|uniprotkb:Q96HN3|uniprotkb:Q9BWM6|uniprotkb:Q9BZV5|uniprotkb:Q9H9M4|uniprotkb:Q9NT89|uniprotkb:Q9NW39|uniprotkb:Q9ULC9|ensembl:ENSP00000265351	psi-mi:pre-let-7a-1(display_short)|psi-mi:EBI-2938324(display_long)	psi-mi:xpo5_human(display_long)|uniprotkb:Ran-binding protein 21(gene name synonym)|uniprotkb:XPO5(gene name)|psi-mi:XPO5(display_short)|uniprotkb:KIAA1291(gene name synonym)|uniprotkb:RANBP21(gene name synonym)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Melo et al. (2010)	pubmed:20951941|imex:IM-15157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2939671|imex:IM-15157-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:2359"(ds rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_065801.1|dip:DIP-34547N|rcsb pdb:5YU7|reactome:R-HSA-203927|ensembl:ENSG00000124571(gene)|ensembl:ENST00000265351(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:1900370"(positive regulation of RNA interference)|go:"GO:1905172"(RISC complex binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040018|mint:Q9HAV4|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|rcsb pdb:3A6P|rcsb pdb:5YU6	-	-	-	figure legend:Fig 4D, S4B.|comment:The biotin labeled pre-let-7a did not bind XPO5Mut in the presence of Ran and GTP.  However pre-let-7a formed a readily detectable complex when incubated with XPO5WT and a supershift could be observed when the antihistidine antibody was added to the reaction.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/10/20	2015/08/24	crc64:577F8A4C0C754DAA	rogid:wuUAxvyCl/u7CRtQLMK9McSoUrM9606	intact-crc:0C6B8810733395CC	false	biotin tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
intact:EBI-2938324	uniprotkb:P62826	ensembl:ENSG00000199165|rnacentral:URS00005EB5B7_9606|mirbase:MI0000060	intact:EBI-286642|uniprotkb:P17080|uniprotkb:P28746|uniprotkb:P28747|uniprotkb:Q6IPB2|uniprotkb:Q86V08|uniprotkb:Q8NI90|uniprotkb:Q9CZA2|uniprotkb:Q9CSP3|uniprotkb:Q9CWI7|uniprotkb:Q9UDJ5|uniprotkb:Q9UEU9|uniprotkb:A8K3Z8|ensembl:ENSP00000376176|ensembl:ENSP00000446215	psi-mi:pre-let-7a-1(display_short)|psi-mi:EBI-2938324(display_long)	psi-mi:ran_human(display_long)|uniprotkb:GTPase Ran(gene name synonym)|uniprotkb:Ras-related nuclear protein(gene name synonym)|uniprotkb:Ras-like protein TC4(gene name synonym)|uniprotkb:Androgen receptor-associated protein 24(gene name synonym)|uniprotkb:RAN(gene name)|psi-mi:RAN(display_short)|uniprotkb:ARA24(gene name synonym)|uniprotkb:OK/SW-cl.81(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Melo et al. (2010)	pubmed:20951941|imex:IM-15157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2939692|imex:IM-15157-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:2359"(ds rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006316.1|refseq:NP_001287725.1|refseq:NP_001287726.1|dip:DIP-5929N|ensembl:ENSG00000132341(gene)|ensembl:ENST00000392369(transcript)|ensembl:ENST00000543796(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0016020"(membrane)|go:"GO:0016032"(viral process)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0061015"(snRNA import into nucleus)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR001806(Ras GTPase)|interpro:IPR002041(Ran GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62826|rcsb pdb:1I2M|rcsb pdb:1IBR|rcsb pdb:1K5D|rcsb pdb:1K5G|rcsb pdb:1QBK|rcsb pdb:1RRP|rcsb pdb:2MMC|rcsb pdb:2MMG|rcsb pdb:2N1B|rcsb pdb:3CH5|rcsb pdb:3EA5|rcsb pdb:3GJ0|rcsb pdb:3GJ3|rcsb pdb:3GJ4|rcsb pdb:3GJ5|rcsb pdb:3GJ6|rcsb pdb:3GJ7|rcsb pdb:3GJ8|rcsb pdb:3GJX|rcsb pdb:3NBY|rcsb pdb:3NBZ|rcsb pdb:3NC0|rcsb pdb:3NC1|rcsb pdb:3ZJY|rcsb pdb:4C0Q|rcsb pdb:4GMX|rcsb pdb:4GPT|rcsb pdb:4HAT|rcsb pdb:4HAU|rcsb pdb:4HAV|rcsb pdb:4HAW|rcsb pdb:4HAX|rcsb pdb:4HAY|rcsb pdb:4HAZ|rcsb pdb:4HB0|rcsb pdb:4HB2|rcsb pdb:4HB3|rcsb pdb:4HB4|rcsb pdb:4OL0|rcsb pdb:4WVF|rcsb pdb:5CIQ|rcsb pdb:5CIT|rcsb pdb:5CIW|rcsb pdb:5CJ2|rcsb pdb:5CLL|rcsb pdb:5CLQ|rcsb pdb:5DH9|rcsb pdb:5DHA|rcsb pdb:5DHF|rcsb pdb:5DI9|rcsb pdb:5DIF|rcsb pdb:5DIS|rcsb pdb:5DLQ|rcsb pdb:5FYQ|rcsb pdb:5JLJ|rcsb pdb:5UWH|rcsb pdb:5UWI|rcsb pdb:5UWJ|rcsb pdb:5UWO|rcsb pdb:5UWP|rcsb pdb:5UWQ|rcsb pdb:5UWR|rcsb pdb:5UWS|rcsb pdb:5UWT|rcsb pdb:5UWU|rcsb pdb:5UWW|rcsb pdb:5YRO|rcsb pdb:5YST|rcsb pdb:5YSU|rcsb pdb:5YTB|rcsb pdb:5ZPU|rcsb pdb:6A38|rcsb pdb:6A3A|rcsb pdb:6A3B|rcsb pdb:6A3C|rcsb pdb:6A3E|rcsb pdb:6CIT|rcsb pdb:6KFT|rcsb pdb:6LQ9|rcsb pdb:6M60|rcsb pdb:6M6X|rcsb pdb:6Q82|rcsb pdb:6Q84|rcsb pdb:6TVO|rcsb pdb:6X2M|rcsb pdb:6X2O|rcsb pdb:6X2P|rcsb pdb:6X2R|rcsb pdb:6X2S|rcsb pdb:6X2U|rcsb pdb:6X2V|rcsb pdb:6X2W|rcsb pdb:6X2X|rcsb pdb:6X2Y|rcsb pdb:6XJP|rcsb pdb:6XJR|rcsb pdb:6XJS|rcsb pdb:6XJT|rcsb pdb:6XJU|rcsb pdb:7B51|rcsb pdb:7CND|rcsb pdb:7L5E|reactome:R-HSA-165054|reactome:R-HSA-1655829|reactome:R-HSA-168333|reactome:R-HSA-180746|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-6784531|reactome:R-HSA-9615933	-	-	-	figure legend:Fig 4E, S4C.|comment:An exothermic reaction  takes place between XPO5WT protein and pre-let-7a in the presence of RanGTP, while no reaction takes place between XPO5Mut and pre-let-7a.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/10/20	2015/08/24	crc64:577F8A4C0C754DAA	rogid:trIUv5n3nI5d0rkfDTgw/6ubxMA9606	intact-crc:F4D843A2E2C8C747	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-2938324	uniprotkb:Q9HAV4	ensembl:ENSG00000199165|rnacentral:URS00005EB5B7_9606|mirbase:MI0000060	intact:EBI-517949|uniprotkb:Q5JTE6|uniprotkb:Q96G48|uniprotkb:Q96HN3|uniprotkb:Q9BWM6|uniprotkb:Q9BZV5|uniprotkb:Q9H9M4|uniprotkb:Q9NT89|uniprotkb:Q9NW39|uniprotkb:Q9ULC9|ensembl:ENSP00000265351	psi-mi:pre-let-7a-1(display_short)|psi-mi:EBI-2938324(display_long)	psi-mi:xpo5_human(display_long)|uniprotkb:Ran-binding protein 21(gene name synonym)|uniprotkb:XPO5(gene name)|psi-mi:XPO5(display_short)|uniprotkb:KIAA1291(gene name synonym)|uniprotkb:RANBP21(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Melo et al. (2010)	pubmed:20951941|imex:IM-15157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2939692|imex:IM-15157-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:2359"(ds rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_065801.1|dip:DIP-34547N|rcsb pdb:5YU7|reactome:R-HSA-203927|ensembl:ENSG00000124571(gene)|ensembl:ENST00000265351(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:1900370"(positive regulation of RNA interference)|go:"GO:1905172"(RISC complex binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040018|mint:Q9HAV4|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|rcsb pdb:3A6P|rcsb pdb:5YU6	-	-	-	figure legend:Fig 4E, S4C.|comment:An exothermic reaction  takes place between XPO5WT protein and pre-let-7a in the presence of RanGTP, while no reaction takes place between XPO5Mut and pre-let-7a.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/10/20	2015/08/24	crc64:577F8A4C0C754DAA	rogid:wuUAxvyCl/u7CRtQLMK9McSoUrM9606	intact-crc:F4D843A2E2C8C747	false	biotin tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)